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Conserved domains on  [gi|515951929|ref|WP_017382512|]
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MULTISPECIES: isochorismate synthase EntC [Enterobacter]

Protein Classification

isochorismate synthase EntC( domain architecture ID 11487569)

isochorismate synthase EntC catalyzes the reversible conversion of chorismate to isochorismate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 1-391 0e+00

isochorismate synthase EntC; Provisional


:

Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 819.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929   1 MDTSLAEDLQHTATTLQSDSFFFMSPYRSFTTSGCFARFSEPAVGGDDPAGPFQQKLAQAFQNAKNSGIAHPVMVGAIPF 80
Cdd:PRK15016   1 MDTSLAEEVQQTMATLAPDRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  81 DTRKPSSLFIPQRWQTFSRPARQQSARYASGAQTLNVQQRTEIPPQPVFEEMVARAASLTATPQVNKVVLSRLIDIATDK 160
Cdd:PRK15016  81 DTRQPSSLYIPESWQSFSRQEKQRSARRFTRSQSLNVVERQAIPEQTTFEAMVARAAALTATPQVDKVVLSRLIDITTDA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 161 QIDSSALMERLIAQNPASFNFHVPLEDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRH 240
Cdd:PRK15016 161 AIDSGALLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRH 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 241 EHDLVTQAMKTILEPRSHHLTMPASPQLITTPTLWHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELE 320
Cdd:PRK15016 241 EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515951929 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTMLNVFGLH 391
Cdd:PRK15016 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 391
 
Name Accession Description Interval E-value
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 1-391 0e+00

isochorismate synthase EntC; Provisional


Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 819.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929   1 MDTSLAEDLQHTATTLQSDSFFFMSPYRSFTTSGCFARFSEPAVGGDDPAGPFQQKLAQAFQNAKNSGIAHPVMVGAIPF 80
Cdd:PRK15016   1 MDTSLAEEVQQTMATLAPDRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  81 DTRKPSSLFIPQRWQTFSRPARQQSARYASGAQTLNVQQRTEIPPQPVFEEMVARAASLTATPQVNKVVLSRLIDIATDK 160
Cdd:PRK15016  81 DTRQPSSLYIPESWQSFSRQEKQRSARRFTRSQSLNVVERQAIPEQTTFEAMVARAAALTATPQVDKVVLSRLIDITTDA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 161 QIDSSALMERLIAQNPASFNFHVPLEDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRH 240
Cdd:PRK15016 161 AIDSGALLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRH 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 241 EHDLVTQAMKTILEPRSHHLTMPASPQLITTPTLWHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELE 320
Cdd:PRK15016 241 EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515951929 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTMLNVFGLH 391
Cdd:PRK15016 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 391
MenF COG1169
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ...
 19-391 3.66e-146

Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440783 [Multi-domain]  Cd Length: 353  Bit Score: 418.40  E-value: 3.66e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  19 DSFFFMSPYRSFT--TSGCFARFSEPavgGDDPAGPFQQKLAQAFQNAKNSGiAHPVMVGAIPFDTRKP---SSLFIPQR 93
Cdd:COG1169    1 PRFYWASPDRGEGlaGLGEAARFEAP---GPDRFAALAAAWQALLADAALAG-TGPRAFGGFAFDPDSPapaARLVLPRL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  94 WQTFSRParqqsaryasgaqtlnvqqrtEIPPQPVFEEMVARAASLTATPQVNKVVLSRLIDIATDKQIDSSALMERLIA 173
Cdd:COG1169   77 LLRRSRR---------------------GVPDPAEWREAVAQALEAIRAGELDKVVLARALDLTLDEPIDPRALLARLRR 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 174 QNPASFNFHVPLEDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEHDLVTQAMKTIL 253
Cdd:COG1169  136 RNPDCYTFAVELGAGDGFVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREAL 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 254 EPRSHHLTMPASPQLITTPTLWHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGW 333
Cdd:COG1169  216 APLCSSLDVPEEPELLRLRNVQHLATPITGTLDPGVSALDLAAALHPTPAVGGTPREAALALIRELEPFDRGWYAGPVGW 295

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 515951929 334 CDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTMLNVFGLH 391
Cdd:COG1169  296 VDADGDGEFAVAIRSALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRALGLE 353
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 129-380 8.89e-89

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 268.65  E-value: 8.89e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  129 FEEMVARAASLTATPQVNKVVLSRLIDIATDKQIDSSALMERLIAQNPASFNFHVPLEDGgVLLGASPELLLRKEGAHFS 208
Cdd:pfam00425   3 YLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGDIDPLALYRRLRARNPAPYSFYFRTGDF-TFLGASPERLLSVDGGRII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  209 SLPLAGSARRQPDDVLDREAGTKLLASEKDRHEH----DLVTQAMKTILEPRShhLTMPASPQLITTPTLWHLATPVEGD 284
Cdd:pfam00425  82 TEPIAGTRPRGKDPAEDEALAAELLADPKERAEHlmvvDLIRNDLGRVCVPGS--VKVPELPEVERYGTVQHLVSTISGR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  285 ARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGI 364
Cdd:pfam00425 160 LKPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGI 239

                         250
                  ....*....|....*.
gi 515951929  365 VPASSPVGEWRETGVK 380
Cdd:pfam00425 240 VADSDPEAEWEETEAK 255
isochor_syn TIGR00543
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ...
 72-388 1.55e-86

isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273127  Cd Length: 351  Bit Score: 266.16  E-value: 1.55e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929   72 PVMVGAIPFDTRKPS--------SLFIPQ---------RWQTFSRPA--------RQQSARYASGAQTLNVQQRTEIPPQ 126
Cdd:TIGR00543   1 PRLFGGFPFDPEEPAaweefgegYFVLPEvlvesdgggTLLTCTIVAepelneadLLLYAKFAVSSGIRPLRALPEQMTT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  127 PVFEEMVARAASLTATPQ---------VNKVVLSRLIDIATDKQIDSSALMERLIAQNPASFNFHVPLEDGGVLLGASPE 197
Cdd:TIGR00543  81 LTTGEDPDKAAWRTAVEEalenirqgpLDKVVLARALTLKFADDIDPIAVLANLRQQYPNAYIFLLEPPQGGVFLGATPE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  198 LLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEHDLVTQAMKTILEPRSHHLTMPASPQLITTPTLWHL 277
Cdd:TIGR00543 161 RLLSREKGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPICTSLDVSETPELLKLANVQHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  278 ATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVR 357
Cdd:TIGR00543 241 YTPISARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLDGEGNGEFAVGIRSALVEDGQVR 320

                         330       340       350
                  ....*....|....*....|....*....|.
gi 515951929  358 LFAGAGIVPASSPVGEWRETGVKLSTMLNVF 388
Cdd:TIGR00543 321 LYAGAGIVADSDPESEWEETELKLQTMLRAL 351
 
Name Accession Description Interval E-value
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 1-391 0e+00

isochorismate synthase EntC; Provisional


Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 819.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929   1 MDTSLAEDLQHTATTLQSDSFFFMSPYRSFTTSGCFARFSEPAVGGDDPAGPFQQKLAQAFQNAKNSGIAHPVMVGAIPF 80
Cdd:PRK15016   1 MDTSLAEEVQQTMATLAPDRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  81 DTRKPSSLFIPQRWQTFSRPARQQSARYASGAQTLNVQQRTEIPPQPVFEEMVARAASLTATPQVNKVVLSRLIDIATDK 160
Cdd:PRK15016  81 DTRQPSSLYIPESWQSFSRQEKQRSARRFTRSQSLNVVERQAIPEQTTFEAMVARAAALTATPQVDKVVLSRLIDITTDA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 161 QIDSSALMERLIAQNPASFNFHVPLEDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRH 240
Cdd:PRK15016 161 AIDSGALLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRH 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 241 EHDLVTQAMKTILEPRSHHLTMPASPQLITTPTLWHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELE 320
Cdd:PRK15016 241 EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515951929 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTMLNVFGLH 391
Cdd:PRK15016 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 391
MenF COG1169
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ...
 19-391 3.66e-146

Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440783 [Multi-domain]  Cd Length: 353  Bit Score: 418.40  E-value: 3.66e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  19 DSFFFMSPYRSFT--TSGCFARFSEPavgGDDPAGPFQQKLAQAFQNAKNSGiAHPVMVGAIPFDTRKP---SSLFIPQR 93
Cdd:COG1169    1 PRFYWASPDRGEGlaGLGEAARFEAP---GPDRFAALAAAWQALLADAALAG-TGPRAFGGFAFDPDSPapaARLVLPRL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  94 WQTFSRParqqsaryasgaqtlnvqqrtEIPPQPVFEEMVARAASLTATPQVNKVVLSRLIDIATDKQIDSSALMERLIA 173
Cdd:COG1169   77 LLRRSRR---------------------GVPDPAEWREAVAQALEAIRAGELDKVVLARALDLTLDEPIDPRALLARLRR 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 174 QNPASFNFHVPLEDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEHDLVTQAMKTIL 253
Cdd:COG1169  136 RNPDCYTFAVELGAGDGFVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREAL 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 254 EPRSHHLTMPASPQLITTPTLWHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGW 333
Cdd:COG1169  216 APLCSSLDVPEEPELLRLRNVQHLATPITGTLDPGVSALDLAAALHPTPAVGGTPREAALALIRELEPFDRGWYAGPVGW 295

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 515951929 334 CDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTMLNVFGLH 391
Cdd:COG1169  296 VDADGDGEFAVAIRSALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRALGLE 353
PRK06923 PRK06923
isochorismate synthase DhbC; Validated
 5-390 1.12e-110

isochorismate synthase DhbC; Validated


Pssm-ID: 235886 [Multi-domain]  Cd Length: 399  Bit Score: 329.77  E-value: 1.12e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929   5 LAEDLQHTATTlqSDSFFFMSPYRSFTTSGCFARFSEPAvggddpAGPFQQKLAQAFQNAKNSGIAHPVMVGAIPFDTRK 84
Cdd:PRK06923  10 LSEKLLEDYKT--ESSFFFASPTRTILAEGEFTTVKHHE------IESFPERVQAVLRNAKQAGNPNPIVVGALPFDRRK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  85 PSSLFIPQRWQTFSR-PARQQSARYASGAQTLNVQQrteIPPQPVFEEMVARAASLTATPQVNKVVLSRLIDIATDKQID 163
Cdd:PRK06923  82 EVQLIVPEYSRISERlQLDTTNHLEINRNLTFEMTP---VPDPEVYMNGVKQGIAKIQDGDLKKIVLSRSLDVKSSEKID 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 164 SSALMERLIAQNPASFNFHVPL-----EDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKD 238
Cdd:PRK06923 159 KQKLLRELAEHNKHGYTFAVNLpkdenENSKTLIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKD 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 239 RHEHDLVTQAMKTILEPRSHHLTMPASPQLITTPTLWHLATPVEGDARE-NENALTLACLLHPTPALSGFPHQAAKELIA 317
Cdd:PRK06923 239 LHEHAVVVEAVAAALRPYCHTLHVPEKPSVIHTEAMWHLSTEVKGELKDpNTSSLELAIALHPTPAVCGTPTEEAREAIQ 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515951929 318 ELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTMLNVFGL 390
Cdd:PRK06923 319 QIEPFDREFFTGMLGWSDLNGDGEWIVTIRCAEVEENTLRLYAGAGVVAESKPEDELAETSAKFQTMLKAMGL 391
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 129-380 8.89e-89

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 268.65  E-value: 8.89e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  129 FEEMVARAASLTATPQVNKVVLSRLIDIATDKQIDSSALMERLIAQNPASFNFHVPLEDGgVLLGASPELLLRKEGAHFS 208
Cdd:pfam00425   3 YLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGDIDPLALYRRLRARNPAPYSFYFRTGDF-TFLGASPERLLSVDGGRII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  209 SLPLAGSARRQPDDVLDREAGTKLLASEKDRHEH----DLVTQAMKTILEPRShhLTMPASPQLITTPTLWHLATPVEGD 284
Cdd:pfam00425  82 TEPIAGTRPRGKDPAEDEALAAELLADPKERAEHlmvvDLIRNDLGRVCVPGS--VKVPELPEVERYGTVQHLVSTISGR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  285 ARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGI 364
Cdd:pfam00425 160 LKPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGI 239

                         250
                  ....*....|....*.
gi 515951929  365 VPASSPVGEWRETGVK 380
Cdd:pfam00425 240 VADSDPEAEWEETEAK 255
isochor_syn TIGR00543
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ...
 72-388 1.55e-86

isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273127  Cd Length: 351  Bit Score: 266.16  E-value: 1.55e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929   72 PVMVGAIPFDTRKPS--------SLFIPQ---------RWQTFSRPA--------RQQSARYASGAQTLNVQQRTEIPPQ 126
Cdd:TIGR00543   1 PRLFGGFPFDPEEPAaweefgegYFVLPEvlvesdgggTLLTCTIVAepelneadLLLYAKFAVSSGIRPLRALPEQMTT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  127 PVFEEMVARAASLTATPQ---------VNKVVLSRLIDIATDKQIDSSALMERLIAQNPASFNFHVPLEDGGVLLGASPE 197
Cdd:TIGR00543  81 LTTGEDPDKAAWRTAVEEalenirqgpLDKVVLARALTLKFADDIDPIAVLANLRQQYPNAYIFLLEPPQGGVFLGATPE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  198 LLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEHDLVTQAMKTILEPRSHHLTMPASPQLITTPTLWHL 277
Cdd:TIGR00543 161 RLLSREKGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPICTSLDVSETPELLKLANVQHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  278 ATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVR 357
Cdd:TIGR00543 241 YTPISARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLDGEGNGEFAVGIRSALVEDGQVR 320

                         330       340       350
                  ....*....|....*....|....*....|.
gi 515951929  358 LFAGAGIVPASSPVGEWRETGVKLSTMLNVF 388
Cdd:TIGR00543 321 LYAGAGIVADSDPESEWEETELKLQTMLRAL 351
PRK07054 PRK07054
isochorismate synthase;
106-384 7.74e-60

isochorismate synthase;


Pssm-ID: 235920 [Multi-domain]  Cd Length: 475  Bit Score: 201.15  E-value: 7.74e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 106 ARYASGAQ-TLNVQQRTEIPPQPVFEEMVARAASLTATPQVNKVVLSRLIDIATDKQIDSSALMERLIAQNPASFNFHVP 184
Cdd:PRK07054 173 ARPAPAADdDAPRLLRASALQAREWQHEVRRAVDAIRGGAFGKVVLARDVLQQYARPVAIGPLLRRLRLRDPHAHLFAFR 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 185 lEDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEHDLVTQAMKTILEPRSHHLTMPA 264
Cdd:PRK07054 253 -RGNACFLGATPERLVRVAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDAIRAALAPLSRALDIPD 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 265 SPQLITTPTLWHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVV 344
Cdd:PRK07054 332 QPSLHRLPRLQHLSTPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGWYAAPIGWLDAHGNGDFAV 411

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 515951929 345 TIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTM 384
Cdd:PRK07054 412 ALRSALITGGACRLFAGCGIVADSEPASEYRETCLKLSGM 451
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 116-390 1.33e-36

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 137.54  E-value: 1.33e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 116 NVQQRTEIPPQPVFEEMVARAasltatpQ-------VNKVVLSRLIDIATDkqIDSSALMERLIAQNPASFNFHVPLEDG 188
Cdd:COG0147  143 HLKGTRSNFTREEYLAAVERA-------KeyiragdIFQVVLSQRFSAPFE--GDPLALYRALRRINPSPYMFYLRFGDF 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 189 gVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEH----DL---------------VTQAM 249
Cdd:COG0147  214 -AIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHlmlvDLarndlgrvcepgsvkVPELM 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 250 KtiLEPRSHhltmpaspqlittptLWHLATPVEGDARENENALTL--ACLlhptPA--LSGFPHQAAKELIAELEPFDRE 325
Cdd:COG0147  293 V--VERYSH---------------VMHLVSTVTGRLRPGLDALDAlrATF----PAgtLTGAPKIRAMEIIDELEPTRRG 351

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515951929 326 LFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTMLNVFGL 390
Cdd:COG0147  352 VYGGAVGYLSFDGNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRALEL 416
PRK15012 PRK15012
menaquinone-specific isochorismate synthase; Provisional
 115-376 2.02e-36

menaquinone-specific isochorismate synthase; Provisional


Pssm-ID: 184974 [Multi-domain]  Cd Length: 431  Bit Score: 137.28  E-value: 2.02e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 115 LNVQQRTEIPPQPVFEEMVARAASLTATPQVNKVVLSRLIDIATDKQIDSSALMERLIAQNPASFNFHVPLEDGGVLLGA 194
Cdd:PRK15012 158 LTTTREQHWPDKTGWTQLIELATKTIAEGELDKVVLARATDLHFASPVNAAAMMAASRRLNLNCYHFYMAFDAENAFLGS 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 195 SPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEHDLVTQAMKTILEPRSHHL-TMPasPQLITTPT 273
Cdd:PRK15012 238 SPERLWRRRDKALRTEALAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVEDICQRLQADTQTLdVLP--PQVLRLRK 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 274 LWHLATPVEGDARENENALTLAcLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEgNGEWVVTIRCARLHQ 353
Cdd:PRK15012 316 VQHLRRCIWTSLNKADDVICLH-QLQPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQ-QSEFCVSLRSAKVSG 393

                        250       260
                 ....*....|....*....|...
gi 515951929 354 NTVRLFAGAGIVPASSPVGEWRE 376
Cdd:PRK15012 394 NVVRLYAGAGIVRGSDPEQEWQE 416
PLN02786 PLN02786
isochorismate synthase
 146-382 2.06e-35

isochorismate synthase


Pssm-ID: 178383 [Multi-domain]  Cd Length: 533  Bit Score: 136.45  E-value: 2.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 146 NKVVLSRLIDIATDKQIDSSALMERLIAQNPASFNFHVPLEDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLD 225
Cdd:PLN02786 281 KKVVLARSSRIITDTDIDPIAWLACLQVEGQNAYQFCLQPPDAPAFIGNTPEQLFHRKGLGVCSEALAATRPRGGSSARD 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 226 REAGTKLLASEKDRHEHDLVTQAMKTILEPRSHHLTMPASPQLITTPTLWHLATPVEGDARENENALTLACLLHPTPALS 305
Cdd:PLN02786 361 LQIELDLLTSPKDDLEFSIVRENIREKLEAICDRVVVEPHKAIRKLARVQHLYAQLAGRLRSEDDEFDILAALHPTPAVC 440

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515951929 306 GFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNgEWVVTIRCARLHQN-TVRLFAGAGIVPASSPVGEWRETGVKLS 382
Cdd:PLN02786 441 GHPTEEARLLIAETESFDRGMYAGPVGWFGGGES-EFAVGIRSALVEKGlGALIYAGTGIVEGSNPSSEWNELELKIS 517
PRK13572 PRK13572
anthranilate synthase component I; Provisional
 129-390 1.18e-32

anthranilate synthase component I; Provisional


Pssm-ID: 237432 [Multi-domain]  Cd Length: 435  Bit Score: 127.16  E-value: 1.18e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 129 FEEMVARAASLTATPQVNKVVLSRLIDIATDkqIDSSALMERLIAQNPASFNFhvPLEDGGVLLGASPELLLRKEGAHFS 208
Cdd:PRK13572 175 FVEMVEKAKEYIYSGDVFQVVLSREYRLKTD--LSPFQLYRNLREINPSPYMF--LLEFDKDVVGASPETMASVENNILK 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 209 SLPLAGSARRQPDDVLDREAGTKLLASEKDRHEH----DLVTQAMKTILEPRSHHLTMPAspQLITTPTLWHLATPVEGD 284
Cdd:PRK13572 251 INPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHvmlvDLARNDVRKVSKSGSVRLERFF--DVVKYSHVQHIESEVVGE 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 285 ARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLhQNTVRLFAGAGI 364
Cdd:PRK13572 329 LKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGAVGYFSNSGNADLAIAIRMAEI-DKVCRVRAGAGI 407

                        250       260
                 ....*....|....*....|....*.
gi 515951929 365 VPASSPVGEWRETGVKLSTMLNVFGL 390
Cdd:PRK13572 408 VADSVPEKEFYETERKMAAVLKALGV 433
PRK13574 PRK13574
anthranilate synthase component I; Provisional
 122-381 7.76e-28

anthranilate synthase component I; Provisional


Pssm-ID: 184155 [Multi-domain]  Cd Length: 420  Bit Score: 113.37  E-value: 7.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 122 EIPPQPVFEEMVARAASLTATPQVNKVVLSRLIdiatdKQIDSSALME---RLIAQNPASFNFHVPLEDGGVLlGASPEL 198
Cdd:PRK13574 153 ESLNKNNYEKIVSESLEYIRSGYIFQVVLSRFY-----RYLFSGDPLRiyyNLRRINPSPYMFYLKFDERYLI-GSSPEL 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 199 LLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEH----DLVTQAMKTILEPRShhLTMPASPQLITTPTL 274
Cdd:PRK13574 227 LFRVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHlmlvDLARNDLGKVCVPGT--VRVPELMYVEKYSHV 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 275 WHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQN 354
Cdd:PRK13574 305 QHIVSKVIGTLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAIAIRTAFLNKD 384

                        250       260
                 ....*....|....*....|....*..
gi 515951929 355 TVRLFAGAGIVPASSPVGEWRETGVKL 381
Cdd:PRK13574 385 LLRIQAGAGIVYDSNPESEYFETEHKL 411
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 96-386 1.95e-24

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 104.72  E-value: 1.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929  96 TFSRPARQQSARYASGAqtlnvqqrteippqpvFEEMVARAASLTATPQVNKVVLSRLIDIATDkqIDSSALMERLIAQN 175
Cdd:PRK13571 215 TFSRPVPEFRAQRTVEE----------------FGAAVEKLVEEIRAGEAFQVVPSQRFEMDTT--ADPLDVYRVLRVTN 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 176 PASFNF--HVPLEDGGV---LLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEH----DLVT 246
Cdd:PRK13571 277 PSPYMYllRVPNSDGGTdfsIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHlmlvDLGR 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 247 QAMKTILEPRSHHLTMPASPQLITTptLWHLATPVEGDARENENAL--TLACLlhPTPALSGFPHQAAKELIAELEPFDR 324
Cdd:PRK13571 357 NDLGRVCRPGTVRVVDFSHIERYSH--VMHLVSTVTGELAEGRTALdaVTACF--PAGTLSGAPKVRAMELIEELEPTRR 432

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515951929 325 ELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTMLN 386
Cdd:PRK13571 433 GLYGGVVGYLDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAAVLR 494
PRK07508 PRK07508
aminodeoxychorismate synthase component I;
163-376 8.23e-22

aminodeoxychorismate synthase component I;


Pssm-ID: 236035 [Multi-domain]  Cd Length: 378  Bit Score: 95.85  E-value: 8.23e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 163 DSSALMERLIAQNPASFNFHVPLeDGGVLLGASPELLLRKEGA-HFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHE 241
Cdd:PRK07508 146 DPLALFWALAARQPVGYGALVDL-GGPVILSRSPELFFRVDGEgWIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAE 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 242 H----DLVTQAMKTILEPRShhLTMPASPQLITTPTLWHLATPVEGDARENenaLTLACLLH---PTPALSGFPHQAAKE 314
Cdd:PRK07508 225 NrmivDLLRNDISRISEVGS--LDVPELFDIETYPTVHQMVSRVRARLLPG---LGLADIFAalfPCGSITGAPKIRAME 299

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515951929 315 LIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQ-NTVRLFAGAGIVPASSPVGEWRE 376
Cdd:PRK07508 300 ILRELEPGPRDLYCGAIGWIAPDGRMRFNVAIRTLSLFPgGRAVFNVGGGIVFDSTAEAEYEE 362
PRK09070 PRK09070
aminodeoxychorismate synthase component I;
144-390 1.09e-19

aminodeoxychorismate synthase component I;


Pssm-ID: 236371 [Multi-domain]  Cd Length: 447  Bit Score: 90.15  E-value: 1.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 144 QVNkvvLSRLIDIATDKQIDSSALMERLIAQNPASFNFHVPLEDGGVLlGASPELLLRKEGAHFSSLPLAGSARRQPDDV 223
Cdd:PRK09070 203 QVN---LSRAWQAQFANAVDPAALYARLRAANPAPFSGLFVAAGRAIV-SSSPERLVSVQGGVVQTRPIAGTRPRFAGDD 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 224 lDREAGTKLLASEKDRHEH----DLVTQAMKTILEPRShhLTMPASPQLITTPTLWHLATPVEGDARENENALTLACLLH 299
Cdd:PRK09070 279 -DAALIRELVGHPKERAEHvmliDLERNDLGRICAPGS--VEVDELMTVESYAHVHHIVSNVRGRLRDGVTPGEVIRAVF 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 300 PTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGV 379
Cdd:PRK09070 356 PGGTITGCPKVRCMQIIAELEQTPRGAYTGSFGYLNRDGDMDLNILIRTAEVQGNQVRFRTGAGIVVDSDPERELDETRA 435

                        250
                 ....*....|.
gi 515951929 380 KLSTMLNVFGL 390
Cdd:PRK09070 436 KARGLLRALEQ 446
pabB PRK15465
aminodeoxychorismate synthase component 1;
169-385 1.55e-17

aminodeoxychorismate synthase component 1;


Pssm-ID: 185362 [Multi-domain]  Cd Length: 453  Bit Score: 83.81  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 169 ERLIAQNPASFNFHVPLEDGGVLlGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEHDLVTQA 248
Cdd:PRK15465 231 LQLNQANRAPFSAFLRLEQGAIL-SLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVDL 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 249 MKTILeprsHHLTMPAS---PQLITT---PTLWHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELEPF 322
Cdd:PRK15465 310 MRNDI----GRVAVAGSvkvPELFVVepfPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQ 385

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515951929 323 DRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTML 385
Cdd:PRK15465 386 RRNAWCGSIGYLSFCGNMDTSITIRTLTAINGQIYCSAGGGIVADSQEEAEYQETFDKVNRIL 448
PRK05940 PRK05940
anthranilate synthase component I;
126-377 4.17e-16

anthranilate synthase component I;


Pssm-ID: 235651 [Multi-domain]  Cd Length: 463  Bit Score: 79.39  E-value: 4.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 126 QPVFEEMVARAASLTATPQVNKVVLSrlIDIATDKQIDSSALMERLIAQNPASFN--FHVPLedgGVLLGASPELLLRKE 203
Cdd:PRK05940 189 QQEYEAAVRQAKKYIQAGDIFQANLS--LRFQTTTSADSWQIYRRLQQINPSPFAsyWRTPW---GDVVSCSPERLVQLQ 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 204 GAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEH----DLVTQAMKTILEPRS----HHLTMPASPQLIttptlw 275
Cdd:PRK05940 264 GNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHimlvDLERNDLGRVCQWGSvevdELLTIERYSHVI------ 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 276 HLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRC---ARLH 352
Cdd:PRK05940 338 HLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLFYGSCGYLDQRGNLDLNILIRTllyTPLS 417

                        250       260
                 ....*....|....*....|....*..
gi 515951929 353 QNTVRLFA--GAGIVPASSPVGEWRET 377
Cdd:PRK05940 418 RGLSTIWGqvGAGIVADSDPEKEWLES 444
PRK06404 PRK06404
anthranilate synthase component I; Reviewed
 127-385 1.78e-15

anthranilate synthase component I; Reviewed


Pssm-ID: 102361 [Multi-domain]  Cd Length: 351  Bit Score: 76.83  E-value: 1.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 127 PVFEEMVARAASLTATPQVNKVVLSRLIDiatdKQIDSSALMERLIAQNPASFNFHVPLEDGGVLlGASPELLLRKEGAH 206
Cdd:PRK06404 105 ISLSLKIKELIELIRAGEVLQVVISREFE----ANIDFKEKLSEFINNDRSRYVFYYRFGKYRVV-GSSPENVFTVNGNI 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 207 FSSLPLAGSArrqPDDVLDREagtkLLASEKDRHEH----DLVTQAMKTILEPRShhLTMPASPQLITTPTLWHLATPVE 282
Cdd:PRK06404 180 INVDPIAGTY---DDKILSNE----LLNSEKDKLEHrmllDLARNDLSKFADIGT--LNVDKVMKIEEFSSVKHLVSQVT 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 283 GdARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGwCDSEGNGEWVVTIRCARLHQNTVRLFAGA 362
Cdd:PRK06404 251 A-KFSNASYRDILASMFPAGTVSGSPKERAIEIINKYEETPRGPYGGAIG-IISKGYTDMALVIRTAYSHGNGFRVRAGA 328

                        250       260
                 ....*....|....*....|...
gi 515951929 363 GIVPASSPVGEWRETGVKLSTML 385
Cdd:PRK06404 329 GIVKDSDPEDEVNEIYSKARSVM 351
PRK13566 PRK13566
anthranilate synthase component I;
165-385 2.19e-15

anthranilate synthase component I;


Pssm-ID: 237429 [Multi-domain]  Cd Length: 720  Bit Score: 78.03  E-value: 2.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 165 SALMERLIAQNPASFNFHVPLEDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEhdl 244
Cdd:PRK13566 280 SEIFRRLKEINPSPYGFFINLGDGEYLVGASPEMFVRVEGRRVETCPISGTIKRGADAIGDAEQIRKLLNSKKDESE--- 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 245 vtqamktileprshhLTM--------------PASPQLI------TTPTLWHLATPVEGDARENENALTlACLLHpTPA- 303
Cdd:PRK13566 357 ---------------LTMctdvdrndksrvcePGSVKVIgrrqieMYSRLIHTVDHVEGRLRPGFDALD-AFLTH-AWAv 419

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 304 -LSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLS 382
Cdd:PRK13566 420 tVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGDMNTGLTLRTIRIKDGVAEVRVGATLLFDSDPEAEEAETELKAS 499


                 ...
gi 515951929 383 TML 385
Cdd:PRK13566 500 ALL 502
PRK13567 PRK13567
anthranilate synthase component I; Provisional
 164-387 3.46e-15

anthranilate synthase component I; Provisional


Pssm-ID: 184148 [Multi-domain]  Cd Length: 468  Bit Score: 76.72  E-value: 3.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 164 SSALMERLIAQNPASFNFHVPLeDGGVLLGASPELLLRKEGAHFSSLPLAGSARRQPDDVLDREAGTKLLASEKDRHEHD 243
Cdd:PRK13567 242 SFQLYQNLKRQNPSPYMYYLNI-DQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHR 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 244 -LVTQAMKTIleprsHHLTMPASPQLITTPTL------WHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELI 316
Cdd:PRK13567 321 mLVDLGRNDI-----HRVSKIGTSKITKLMVIekyehvMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERI 395

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515951929 317 AELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVKLSTMLNV 387
Cdd:PRK13567 396 YEQYPHKRGVYSGGVGYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEV 466
PRK06772 PRK06772
salicylate synthase;
129-384 7.38e-15

salicylate synthase;


Pssm-ID: 102546 [Multi-domain]  Cd Length: 434  Bit Score: 75.54  E-value: 7.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 129 FEEMVARAASLTATPQVNKVVLSRLIDIATDKQIDSSALMERLIAQNPASFNFHvplEDGGVLLGASPELLLRKEGAHFS 208
Cdd:PRK06772 175 YKQQVARAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFR---QEGREALGFSPELVMSVTGNKVV 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 209 SLPLAGSARRQPDDVLDREAGTKLLASEKDRHEHDLVTQA----MKTILEPRShhLTMPASPQLITTPTLWHLATPVEGD 284
Cdd:PRK06772 252 TEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEaiaeLEAVCQPGS--VVVEDLMSVRQRGSVQHLGSGVSGQ 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 285 ARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDsEGNGEWVVTIRCARLHQNTVRLFAGAGI 364
Cdd:PRK06772 330 LAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLD-DTRFDAALVLRSVFQDSQRCWIQAGAGI 408

                        250       260
                 ....*....|....*....|
gi 515951929 365 VPASSPVGEWRETGVKLSTM 384
Cdd:PRK06772 409 IAQSTPERELTETREKLASI 428
PRK05877 PRK05877
aminodeoxychorismate synthase component I; Provisional
 195-386 1.05e-11

aminodeoxychorismate synthase component I; Provisional


Pssm-ID: 235634 [Multi-domain]  Cd Length: 405  Bit Score: 65.88  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 195 SPELLLRKEGAHFSSLPLAGSARRQPDDVLdreagtkLLASEKDRHEH----DLVTQAMKTILEPRShhLTMPASPQLIT 270
Cdd:PRK05877 207 SPELFLRRRGSVVTSSPIKGTLPLDADPSA-------LRASAKDVAENimivDLVRNDLGRVARTGT--VTVPELLVVRP 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 271 TPTLWHLATPVEGDARENENALTLACLLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAR 350
Cdd:PRK05877 278 APGVWHLVSTVSAQVPDELPMSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASPVAGCELNVAIRTVE 357

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 515951929 351 LHQN-TVRLFAGAGIVPASSPVGEWRETGVKLSTMLN 386
Cdd:PRK05877 358 FDADgNAVLGVGGGITADSDPDAEWQECLHKAAPIVG 394
PRK07912 PRK07912
salicylate synthase;
129-384 1.19e-10

salicylate synthase;


Pssm-ID: 169151 [Multi-domain]  Cd Length: 449  Bit Score: 62.89  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 129 FEEMVARAASLTATPQVNKVVLSRLIDIATdkQIDSSALMERLIAQNPASFNFHVPLedGGV-LLGASPELL--LRKEGA 205
Cdd:PRK07912 186 YRDRVAVAVAEIAAGRYHKVILSRCVEVPF--AVDFPATYRLGRRHNTPVRSFLLRL--GGIrALGYSPELVtaVRADGV 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 206 hFSSLPLAGSAR--RQPDDvlDREAGTKLLASEKDRHEHDLVTQA----MKTILEPRShhltmPASPQLITTP---TLWH 276
Cdd:PRK07912 262 -VITEPLAGTRAfgRGAAI--DRLARDDLESNSKEIVEHAISVRSslaeITEIAEPGS-----AAVIDFMTVRergSVQH 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 277 LATPVEGD---ARENENALTLaclLHPTPALSGFPHQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQ 353
Cdd:PRK07912 334 LGSTVRGRldaSSDRMDALEA---LFPAVTASGIPKAAGVDAIFRLDEAPRGLYSGAVVMLSADGGLDAALTLRAAYQVG 410

                        250       260       270
                 ....*....|....*....|....*....|.
gi 515951929 354 NTVRLFAGAGIVPASSPVGEWRETGVKLSTM 384
Cdd:PRK07912 411 GRTWLRAGAGIIEESEPEREFEETCEKLSTL 441
PLN02889 PLN02889
oxo-acid-lyase/anthranilate synthase
 161-380 2.66e-08

oxo-acid-lyase/anthranilate synthase


Pssm-ID: 215481 [Multi-domain]  Cd Length: 918  Bit Score: 56.01  E-value: 2.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 161 QIDSSALMERLIAQNPASF----NFHvplEDGGVLLGASPELLLR-KEGAHFSSLPLAGSARRQPDDVLDREAGTKLLAS 235
Cdd:PLN02889 677 EIDSLGLYLHLREKNPAPYaawlNFS---NENLCICSSSPERFLKlDRNGMLEAKPIKGTIARGSTPEEDEQLKLQLQYS 753

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 236 EKDRHEH----DLVTQAMKTILEPRSHHLtmpasPQLI---TTPTLWHLATPVEGDARENENALTLACLLHPTPALSGFP 308
Cdd:PLN02889 754 EKDQAENlmivDLLRNDLGRVCEPGSVHV-----PNLMdveSYTTVHTMVSTIRGKKRSNMSPVDCVRAAFPGGSMTGAP 828

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515951929 309 HQAAKELIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRETGVK 380
Cdd:PLN02889 829 KLRSMELLDSLESSSRGIYSGSIGFFSYNQTFDLNIVIRTVVIHEGEASIGAGGAIVALSNPEDEYEEMILK 900
PRK13564 PRK13564
anthranilate synthase component 1;
191-377 3.03e-04

anthranilate synthase component 1;


Pssm-ID: 237428 [Multi-domain]  Cd Length: 520  Bit Score: 42.90  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 191 LLGASPElllrkegahfSSL------------PLAGSARR--QPDDVLDREAGTK----LLASEKDRHEH----DLVTQA 248
Cdd:PRK13564 303 LFGASPE----------SALkydassrqveiyPIAGTRPRgrRADGSIDRDLDSRieleLRTDHKELAEHlmlvDLARND 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951929 249 MKTILEPRSHHLT-----------MpaspqlittptlwHLATPVEGDARENENALTL--ACLLHPTpaLSGFPHQAAKEL 315
Cdd:PRK13564 373 LARICQPGSRYVAdllkvdryshvM-------------HLVSRVVGELRHDLDALHAyrACMNMGT--LTGAPKVRAMQL 437

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515951929 316 IAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCARLHQNTVRLFAGAGIVPASSPVGEWRET 377
Cdd:PRK13564 438 IREVEGQRRGSYGGAVGYLTGHGDLDTCIVIRSAFVENGIATVQAGAGVVLDSDPQSEADET 499
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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