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Conserved domains on  [gi|515951777|ref|WP_017382360|]
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GNAT family N-acetyltransferase [Enterobacter hormaechei]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18514852)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|9175471|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 85-157 1.98e-12

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 60.05  E-value: 1.98e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515951777  85 QPENQPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGS-GAETFYQRAGWQKAGEIPRY 157
Cdd:COG0456    6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNeAAIALYEKLGFEEVGERPNY 79
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
5-163 4.21e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 52.69  E-value: 4.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777   5 MLIKPLSRQDIlthiDALNDILVNCVNGGASVSFMLPFSAGKAQTFWVGVADsvgrDERTVLGCfDAEQGLVGTVQLITD 84
Cdd:COG1247    2 MTIRPATPEDA----PAIAAIYNEAIAEGTATFETEPPSEEEREAWFAAILA----PGRPVLVA-EEDGEVVGFASLGPF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777  85 QPENQPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGS-GAETFYQRAGWQKAGEIPRYALMPNG 163
Cdd:COG1247   73 RPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNeASIALYEKLGFEEVGTLPEVGFKFGR 152
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 85-157 1.98e-12

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 60.05  E-value: 1.98e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515951777  85 QPENQPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGS-GAETFYQRAGWQKAGEIPRY 157
Cdd:COG0456    6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNeAAIALYEKLGFEEVGERPNY 79
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
5-163 4.21e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 52.69  E-value: 4.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777   5 MLIKPLSRQDIlthiDALNDILVNCVNGGASVSFMLPFSAGKAQTFWVGVADsvgrDERTVLGCfDAEQGLVGTVQLITD 84
Cdd:COG1247    2 MTIRPATPEDA----PAIAAIYNEAIAEGTATFETEPPSEEEREAWFAAILA----PGRPVLVA-EEDGEVVGFASLGPF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777  85 QPENQPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGS-GAETFYQRAGWQKAGEIPRYALMPNG 163
Cdd:COG1247   73 RPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNeASIALYEKLGFEEVGTLPEVGFKFGR 152
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 72-150 2.30e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 48.99  E-value: 2.30e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515951777   72 EQGLVGTVQLITDQPENQPHRADVAkllVHENARRKGAAMALMEALEVVAREKALTVLVLDTSsgSGAETFYQRAGWQK 150
Cdd:pfam13508  11 DGKIVGFAALLPLDDEGALAELRLA---VHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETT--NRAAAFYEKLGFEE 84
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 75-132 6.08e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.88  E-value: 6.08e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 515951777  75 LVGTVQLITDQPEnqPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLD 132
Cdd:cd04301   10 IVGFASLSPDGSG--GDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 85-157 1.98e-12

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 60.05  E-value: 1.98e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515951777  85 QPENQPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGS-GAETFYQRAGWQKAGEIPRY 157
Cdd:COG0456    6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNeAAIALYEKLGFEEVGERPNY 79
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 71-172 1.28e-11

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 58.85  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777  71 AEQG--LVGTVQLITDQPENqphrADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTssGSGAETFYQRAGW 148
Cdd:COG1246   33 AEEDgeIVGCAALHPLDEDL----AELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLT--TSAAIHFYEKLGF 106

                         90       100
                 ....*....|....*....|....
gi 515951777 149 QkagEIPRYALMPNGDMTATSVFY 172
Cdd:COG1246  107 E---EIDKEDLPYAKVWQRDSVVM 127
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
60-153 4.19e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.79  E-value: 4.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777  60 RDERTVLGCFDAEQG--LVGTVQLITDQPENQPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGS 137
Cdd:COG3153   33 REDPAAGLSLVAEDDgeIVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSL 112

                         90
                 ....*....|....*.
gi 515951777 138 GAetFYQRAGWQKAGE 153
Cdd:COG3153  113 LP--FYERFGFRPAGE 126
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 75-161 3.83e-10

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 55.06  E-value: 3.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777  75 LVGTVQLitdQPENQPHrADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSG-SGAETFYQRAGWQKAGE 153
Cdd:COG0454   45 PIGFAGL---RRLDDKV-LELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGnPAAIRFYERLGFKEIER 120


                 ....*...
gi 515951777 154 IPRYALMP 161
Cdd:COG0454  121 YVAYVGGE 128
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
5-163 4.21e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 52.69  E-value: 4.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777   5 MLIKPLSRQDIlthiDALNDILVNCVNGGASVSFMLPFSAGKAQTFWVGVADsvgrDERTVLGCfDAEQGLVGTVQLITD 84
Cdd:COG1247    2 MTIRPATPEDA----PAIAAIYNEAIAEGTATFETEPPSEEEREAWFAAILA----PGRPVLVA-EEDGEVVGFASLGPF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777  85 QPENQPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGS-GAETFYQRAGWQKAGEIPRYALMPNG 163
Cdd:COG1247   73 RPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNeASIALYEKLGFEEVGTLPEVGFKFGR 152
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 72-150 2.30e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 48.99  E-value: 2.30e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515951777   72 EQGLVGTVQLITDQPENQPHRADVAkllVHENARRKGAAMALMEALEVVAREKALTVLVLDTSsgSGAETFYQRAGWQK 150
Cdd:pfam13508  11 DGKIVGFAALLPLDDEGALAELRLA---VHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETT--NRAAAFYEKLGFEE 84
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 60-148 2.45e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.82  E-value: 2.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777   60 RDERTVLGCFDAEQG--LVGTVQLITDQPEnqPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGS 137
Cdd:pfam00583  27 WDEDASEGFFVAEEDgeLVGFASLSIIDDE--PPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADN 104

                          90
                  ....*....|..
gi 515951777  138 -GAETFYQRAGW 148
Cdd:pfam00583 105 lAAIALYEKLGF 116
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
59-154 2.55e-08

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 50.18  E-value: 2.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777  59 GRDERTV-LGCFDAEQgLVGTVQLItdqpenqPHRADVAKL---LVHENARRKGAAMALMEALEVVAREKALTVLVLDTS 134
Cdd:COG2153   29 GKDEDARhLLAYDDGE-LVATARLL-------PPGDGEAKIgrvAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQ 100

                         90       100
                 ....*....|....*....|
gi 515951777 135 SGsgAETFYQRAGWQKAGEI 154
Cdd:COG2153  101 AH--AVGFYEKLGFVPVGEE 118
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
90-162 7.30e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 47.60  E-value: 7.30e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515951777  90 PHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGS-GAETFYQRAGWQKAGEIPRYALMPN 162
Cdd:COG3393   13 PGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNpAARRLYERLGFRPVGEYATVLFRKP 86
Eis COG4552
Predicted acetyltransferase [General function prediction only];
5-159 1.92e-06

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 46.82  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777   5 MLIKPLSRQDIlthiDALNDILVNCvnggasvsFMLPFSAGKAQTFWVGVadsvgrDERTVLGCFDAEQgLVGTVQLItd 84
Cdd:COG4552    1 MEIRPLTEDDL----DAFARLLAYA--------FGPEPDDEELEAYRPLL------EPGRVLGVFDDGE-LVGTLALY-- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777  85 qpenqPHR-------------ADVAkllVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGSgaetFYQRAGWQKA 151
Cdd:COG4552   60 -----PFTlnvggarvpmagiTGVA---VAPEHRRRGVARALLREALAELRERGQPLSALYPFEPG----FYRRFGYELA 127


                 ....*...
gi 515951777 152 GEIPRYAL 159
Cdd:COG4552  128 GDRRRYTI 135
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 75-132 6.08e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.88  E-value: 6.08e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 515951777  75 LVGTVQLITDQPEnqPHRADVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLD 132
Cdd:cd04301   10 IVGFASLSPDGSG--GDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 64-153 3.30e-05

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 41.49  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777   64 TVLGCFDAEQgLVGTVQLITDQpenqpHradVAKLLVHENARRKGAAMALMEALEVVAREKALTVLVLDTSSGSGAETFY 143
Cdd:pfam13673  32 FFFVAFEGGQ-IVGVIALRDRG-----H---ISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPYAVPFY 102

                          90
                  ....*....|
gi 515951777  144 QRAGWQKAGE 153
Cdd:pfam13673 103 EKLGFRATGP 112
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 61-148 3.32e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 36.01  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951777   61 DERTVLGCFDAEQgLVGTVQLItdqpenqPHR-------------ADVAkllVHENARRKGAAMALMEALEVVAREKALT 127
Cdd:pfam13527  37 EEGRVLGAFDDGE-LVSTLALY-------PFElnvpgktlpaagiTGVA---TYPEYRGRGVMSRLLRRSLEEMRERGVP 105

                          90       100
                  ....*....|....*....|.
gi 515951777  128 VLVLDTSSGSgaetFYQRAGW 148
Cdd:pfam13527 106 LSFLYPSSYP----IYRRFGY 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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