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Conserved domains on  [gi|515936869|ref|WP_017367452|]
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MULTISPECIES: nitroreductase family protein [Bacillus]

Protein Classification

nitroreductase family protein( domain architecture ID 10114825)

nitroreductase family protein may catalyze the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles, requiring NAD(P)H as an electron donor in an obligatory two-electron transfer and using FMN as cofactor

CATH:  3.40.109.10
EC:  1.7.1.-
Gene Ontology:  GO:0016491
PubMed:  25702712|7601851|29078300
SCOP:  3001947

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 9-201 5.15e-66

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


:

Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 199.77  E-value: 5.15e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   9 DILKERASVKEYDTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIAYNQKQISQASAVIAVLGDLe 88
Cdd:cd02137    2 EVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAAYNQPQVTTASAVILVLGDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  89 anlkgekiyselaeqgfitediketlmtqingayqseqyareaaysNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVKE 168
Cdd:cd02137   81 ----------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKVAEL 114

                        170       180       190
                 ....*....|....*....|....*....|...
gi 515936869 169 FNVSGRYEPVMLISVGKAAKEAHKSNRFDIEEV 201
Cdd:cd02137  115 LNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
 
Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 9-201 5.15e-66

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 199.77  E-value: 5.15e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   9 DILKERASVKEYDTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIAYNQKQISQASAVIAVLGDLe 88
Cdd:cd02137    2 EVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAAYNQPQVTTASAVILVLGDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  89 anlkgekiyselaeqgfitediketlmtqingayqseqyareaaysNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVKE 168
Cdd:cd02137   81 ----------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKVAEL 114

                        170       180       190
                 ....*....|....*....|....*....|...
gi 515936869 169 FNVSGRYEPVMLISVGKAAKEAHKSNRFDIEEV 201
Cdd:cd02137  115 LNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 7-201 7.18e-44

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 143.84  E-value: 7.18e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   7 TIDILKERASVKEYdTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPI--AYNQKQISQASAVIAVL 84
Cdd:COG0778    1 LLELLLTRRSVRKF-TDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEAlaEANQEWVADAPVLIVVC 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  85 GDLEAnlkgekiyselaeqgfitediketlmtqingayqSEQYAREAAYSNASLAAMQLMIAAKAMGYDTCAMGGFSKEA 164
Cdd:COG0778   80 ADPDR----------------------------------SEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEK 125

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 515936869 165 YVKEFNVSGRYEPVMLISVGKAAKEAHKSNRFDIEEV 201
Cdd:COG0778  126 VRELLGLPEGEEPVALLALGYPAEELNPRPRKPLEEV 162
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 11-185 5.79e-34

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 118.65  E-value: 5.79e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   11 LKERASVKEYDTTHeMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIAYNQKQISQASAVIAVLGDLEAn 90
Cdd:pfam00881   1 IRQRRSVRKFDPEP-VPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAALLLLLRRDAN- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   91 lkGEKIYSELAEQGFITEDIKETLMTQIngaYQSEQYAREAAYSNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVKEFN 170
Cdd:pfam00881  79 --LKLLLQDFLRGAPVLIVITASLSTYL---RKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELLG 153

                         170
                  ....*....|....*
gi 515936869  171 VSGRYEPVMLISVGK 185
Cdd:pfam00881 154 LPDDERLVGLIAVGY 168
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 27-201 4.04e-14

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 67.53  E-value: 4.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  27 TKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLP--IAYNQKQISQAsAVIAVLG-DLEanlkgekIYSELAEQ 103
Cdd:PRK05365  28 SDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPalSEGNLAKTLAA-PVTAIVAyDTE-------FHEHLPKL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869 104 gFITEDIKEtlmtqingAYQSEQYAREA-AYSNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVKEFNVSGRYEPVMLIS 182
Cdd:PRK05365 100 -FPHADARS--------WFAGNPALAEEtAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAGTTWKSNFLVN 170

                        170       180
                 ....*....|....*....|.
gi 515936869 183 VGKAAKEAH--KSNRFDIEEV 201
Cdd:PRK05365 171 IGYGDPAKLfpRLPRLSFDEA 191
 
Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 9-201 5.15e-66

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 199.77  E-value: 5.15e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   9 DILKERASVKEYDTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIAYNQKQISQASAVIAVLGDLe 88
Cdd:cd02137    2 EVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAAYNQPQVTTASAVILVLGDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  89 anlkgekiyselaeqgfitediketlmtqingayqseqyareaaysNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVKE 168
Cdd:cd02137   81 ----------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKVAEL 114

                        170       180       190
                 ....*....|....*....|....*....|...
gi 515936869 169 FNVSGRYEPVMLISVGKAAKEAHKSNRFDIEEV 201
Cdd:cd02137  115 LNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 7-201 7.18e-44

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 143.84  E-value: 7.18e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   7 TIDILKERASVKEYdTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPI--AYNQKQISQASAVIAVL 84
Cdd:COG0778    1 LLELLLTRRSVRKF-TDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEAlaEANQEWVADAPVLIVVC 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  85 GDLEAnlkgekiyselaeqgfitediketlmtqingayqSEQYAREAAYSNASLAAMQLMIAAKAMGYDTCAMGGFSKEA 164
Cdd:COG0778   80 ADPDR----------------------------------SEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEK 125

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 515936869 165 YVKEFNVSGRYEPVMLISVGKAAKEAHKSNRFDIEEV 201
Cdd:COG0778  126 VRELLGLPEGEEPVALLALGYPAEELNPRPRKPLEEV 162
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 14-199 7.13e-35

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 121.66  E-value: 7.13e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  14 RASVKEYdTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIAYNQKQISQASAVIAVLGDLE---AN 90
Cdd:cd03370    8 RRSIRKY-TQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAAAYGQAQVTSAPAVIVIYSDMEdalAN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  91 LkgekiySELAEQGFiTEDIKETLMTQINGAYQSEQYAREAAYSN--ASLAAMQLMIAAKAMGYDTCAMGGFSKEAyVKE 168
Cdd:cd03370   87 L------EETIHPGL-SEERRQREAAGLRGAFGKMSVEQRGQWGLaqANIALGFLLLAAQSLGYDTSPMLGFDPEK-VKA 158

                        170       180       190
                 ....*....|....*....|....*....|..
gi 515936869 169 -FNVSGRYEPVMLISVGKAAKEAHKSNRFDIE 199
Cdd:cd03370  159 lLGLPEHVTIAALVALGKPAEEGYPHHRHSLE 190
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 11-185 5.79e-34

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 118.65  E-value: 5.79e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   11 LKERASVKEYDTTHeMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIAYNQKQISQASAVIAVLGDLEAn 90
Cdd:pfam00881   1 IRQRRSVRKFDPEP-VPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAALLLLLRRDAN- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   91 lkGEKIYSELAEQGFITEDIKETLMTQIngaYQSEQYAREAAYSNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVKEFN 170
Cdd:pfam00881  79 --LKLLLQDFLRGAPVLIVITASLSTYL---RKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELLG 153

                         170
                  ....*....|....*
gi 515936869  171 VSGRYEPVMLISVGK 185
Cdd:pfam00881 154 LPDDERLVGLIAVGY 168
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 8-201 6.76e-27

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 100.40  E-value: 6.76e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   8 IDILKERASVKEYDTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIA-YNQKQISQASAVIAVLGD 86
Cdd:cd02149    3 LELLNFRYATKKFDPNKKISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPAAwFNQPQIKDASHVVVFLAK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  87 LEanlkgekiyselaeqgfitediketlmtqingayqseqYAREAAYsnasLAAMQLMIAAKAMGYDTCAMGGFSKEAYV 166
Cdd:cd02149   83 KD--------------------------------------WSAKQTY----IALGNMLLAAAMLGIDSCPIEGFDPAKLD 120

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 515936869 167 KEFNVS-GRYEPVMLISVGKAAKEAHKSNRFDIEEV 201
Cdd:cd02149  121 EILGLDeKGYKISVMVAFGYRSEEKLPKSRKPLEDV 156
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 11-184 1.92e-24

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 93.52  E-value: 1.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  11 LKERASVKEYDTThEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKL-LPIAYNQKQISQASAVIAVLGDLEA 89
Cdd:cd02062    1 IKTRRSIRKFTDK-PVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLaKLAAPNQKFIAGAPVVIVVVADPDK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  90 NlkgekiyselaeQGFITEDiketlmtqingayqseqyareaaysnASLAAMQLMIAAKAMGYDTCAMGGFSK-EAYVKE 168
Cdd:cd02062   80 S------------RPWALED--------------------------AGAAAQNLLLAAAALGLGSCWIGGFDFrEDKVRE 121

                        170
                 ....*....|....*..
gi 515936869 169 -FNVSGRYEPVMLISVG 184
Cdd:cd02062  122 lLGIPENLRPVALIAIG 138
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 29-201 2.35e-20

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 83.84  E-value: 2.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  29 EELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLP--IAYNQKQISQASaVIAVLG-DLEanlkgekIYSELAEQGF 105
Cdd:cd02148   23 EELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPhlSEGNREKTMAAP-VTAILAyDTE-------FYEHLPRLFP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869 106 ITEDIKETlmtqingAYQSEQYAREAAYSNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVKEFNVSGRYEPVMLISVGK 185
Cdd:cd02148   95 HGDARSWF-------FGSGPARAEETAFRNASLQAAYFILAARALGLDCGPMSGFDAAGVDAEFFAGTRWKSNLVVNLGY 167

                        170
                 ....*....|....*...
gi 515936869 186 AAKEAH--KSNRFDIEEV 201
Cdd:cd02148  168 GDPSKLfpRLPRLDFDEA 185
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 8-201 6.45e-18

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 77.13  E-value: 6.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   8 IDILKERASVKEYDTThEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIAYNQKQISQASAVIAVLGDL 87
Cdd:cd02139    2 YEAIKKRRSIRKYKPT-PVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLAEAANGQKFIAEAPVVIVACADP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  88 EANLKGEKIYSELAeqgfitediketlmtqingayqseqyareaaysNASLAAMQLMIAAKAMGYDTCAMGGFsKEAYVK 167
Cdd:cd02139   81 SESGMGCGKPYYLV---------------------------------DVAIAMEHLVLAATEEGLGTCWIGAF-DEDKVK 126

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 515936869 168 E-FNVSGRYEPVMLISVGKAAKEAHKSNRFDIEEV 201
Cdd:cd02139  127 EiLGIPEEYRVVALTPLGYPAEEPPPRPRKPLEEI 161
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 10-200 1.34e-16

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 73.73  E-value: 1.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  10 ILKERASVKEYDTThEMTKEELTELLDITTKAPSAWNLQHWHFTVFH-SAESKAKL--LPIAYNQKQISQASAVIAVLGD 86
Cdd:cd02138    1 LIAERWSPRAFSPE-PISEEDLLSLFEAARWAPSCFNEQPWRFVVARrDTEAFEKLldLLAEGNQSWAKNAPVLIVVLAK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  87 leanlkgekiyselaeqgfiTEDIKetlmtqingayqSEQYAREAAYsNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYV 166
Cdd:cd02138   80 --------------------TEFDH------------NGKPNRYALF-DTGAAVANLALQATALGLVVHQMAGFDPEKAK 126

                        170       180       190
                 ....*....|....*....|....*....|....
gi 515936869 167 KEFNVSGRYEPVMLISVGKAAKEAHKSNRFDIEE 200
Cdd:cd02138  127 EALGIPDEYEPITMIAIGYPGDPESLPEKLLERE 160
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 8-184 7.74e-16

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 70.88  E-value: 7.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   8 IDILKERASVKEYDTThEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIAynqKQISQASAVIAVLGDL 87
Cdd:cd20609    3 LELAKKRYSVRKFSDK-PVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKAT---PRFFGAPLVIVVCYDK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  88 EAnlkgekiyselaeqgfitediketlmtqingAYQSEQYAREAAYSNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVK 167
Cdd:cd20609   79 DE-------------------------------SWKRPYDGKDSGDIDAAIVATHMMLAATELGLGTCWVGNFDPEKVRE 127

                        170
                 ....*....|....*..
gi 515936869 168 EFNVSGRYEPVMLISVG 184
Cdd:cd20609  128 AFNLPENLEPVAILPLG 144
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 7-201 4.24e-15

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 71.11  E-value: 4.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   7 TIDILKERASVKEYdTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLPIAYNQKQISQASAVIAVLGD 86
Cdd:cd02146    1 TIETILNHRSVRKF-TDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKLAELAGNQPYVAQAPVFLVFCAD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  87 LEANLKgekiyseLAEQGFITEDIKETLMTQINGAyqseqyareaaySNASLAAMQLMIAAKAMGYDTCAMGGFSK--EA 164
Cdd:cd02146   80 LYRHQK-------IAEEAGGKDVGLDYLESFLVGV------------VDAALAAQNALVAAESLGLGIVYIGGIRNnpEE 140

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 515936869 165 YVKEFNVSGRYEPVMLISVGKAAKEAHKSNRFDIEEV 201
Cdd:cd02146  141 VIELLGLPEYVFPLFGLTVGHPDPTPEVKPRLPLEAV 177
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 27-201 4.04e-14

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 67.53  E-value: 4.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  27 TKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLP--IAYNQKQISQAsAVIAVLG-DLEanlkgekIYSELAEQ 103
Cdd:PRK05365  28 SDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPalSEGNLAKTLAA-PVTAIVAyDTE-------FHEHLPKL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869 104 gFITEDIKEtlmtqingAYQSEQYAREA-AYSNASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVKEFNVSGRYEPVMLIS 182
Cdd:PRK05365 100 -FPHADARS--------WFAGNPALAEEtAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAGTTWKSNFLVN 170

                        170       180
                 ....*....|....*....|.
gi 515936869 183 VGKAAKEAH--KSNRFDIEEV 201
Cdd:PRK05365 171 IGYGDPAKLfpRLPRLSFDEA 191
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
5-189 2.58e-13

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 65.76  E-value: 2.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   5 QKTIDILKERASVKEYDTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKLLP-----IAYNQKQISQASA 79
Cdd:PRK11053   1 MDIVSVAKKRYTTKAFDPSKKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEGKARIAKaaagnYAFNERKILDASH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  80 VIAV-----LGD--LEANLKGEKiyselAEQGFITEDIKEtlmTQING------AYQSEQyaREAAY---SNASLAAMQL 143
Cdd:PRK11053  81 VVVFcaktdMDDayLELVLEQED-----ADGRFATEEAKA---AQDKGrrffadMHRKEL--KDLQHwmeKQVYLALGNL 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 515936869 144 MIAAKAMGYDTCAMGGFSKEAYVKEFNVSGR-YEPVMLISVGKAAKE 189
Cdd:PRK11053 151 LLGAAALGIDATPIEGFDAAILDAEFGLREKgLTSSVVVPLGYHSEE 197
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 11-199 7.43e-13

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 63.39  E-value: 7.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  11 LKERASVKEYdTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKL---LPIAynqKQISQASAVIAVLGDL 87
Cdd:cd02150    1 ILTRRSIRKY-TDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIaeaHPYG---KMLKEAPLAIVVCGDP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  88 EAnlkgEKIyselaeQGFITEDiketlmtqingayqseqyareaaysnASLAAMQLMIAAKAMGYDTCAMGGFSKE---- 163
Cdd:cd02150   77 SK----EKA------PGYWVQD--------------------------CSAATENILLAAHALGLGAVWLGVYPFEervk 120

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 515936869 164 AYVKEFNVSGRYEPVMLISVGKAAKEAHKSNRFDIE 199
Cdd:cd02150  121 AIREILNIPENIIPFCVIALGYPAEEKEPKDRFDEE 156
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 9-192 2.30e-12

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 62.16  E-value: 2.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   9 DILKERASVKEYdTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVfhsAESKAKLLPIA----YNQKQISQASAVIAVL 84
Cdd:cd02151    1 ELLKKRRSIRKY-TDEPIEEEKLEEILEAALLAPSSRNSRPVEFIV---VDDKETLKKLSeckpHGSAFLKGAPAAIVVL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  85 GDLEANlkgekiyselaeqGFITEDiketlmtqingayqseqyareaaysnASLAAMQLMIAAKAMGYDTC------AMG 158
Cdd:cd02151   77 ADTEKS-------------DTWIED--------------------------ASIAATYIQLAAESLGLGSCwiqirnRET 117

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 515936869 159 --GFSKEAYVKE-FNVSGRYEPVMLISVGKAA--KEAHK 192
Cdd:cd02151  118 qdGKTAEEYVRElLGIPENYRVLCIIALGYPDeeKPPHE 156
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 11-184 1.03e-11

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 60.75  E-value: 1.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  11 LKERASVKEYdTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVFhSAESKAKLLPIAYNQKQisqasAVIAVLGDLEAN 90
Cdd:cd20610    1 IKKRRSIRKF-KPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVV-KGGEKIEKIGISIKKKN-----EEIARLLEKVFA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  91 LKGEKIysELAEQGFITEDIKETLMTQINGAYQSEQYaREAAYSNASlAAMQ-LMIAAKAMGYDTCAMGG-FSKEAYVKE 168
Cdd:cd20610   74 EKPIRF--RKFRRFFTLFGGAPVLVVVYTEPYKPPEE-RKPDLQSVS-AAIQnLLLAAHALGLGTCWMTGpLYAEDEIEE 149

                        170
                 ....*....|....*..
gi 515936869 169 FN-VSGRYEPVMLISVG 184
Cdd:cd20610  150 ILeIPDDKELVAVTPLG 166
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 11-203 1.51e-10

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 57.21  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  11 LKERASVKEYDTThEMTKEELTELLDITTKAPSAWNLQHWHFTVFhSAESKAKLLPIAYNqkqisqASAVIAVLGDlean 90
Cdd:cd02136    2 IKSRRSVRAFKDK-PVPKETIEKILEAARRAPSGKNTQPWRVYVV-TGKARERLKKAFFG------APVALFLTMD---- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  91 lKGEKIYSELaeqgfiteDIketlmtqingayqseqyareaaysnaSLAAMQLMIAAKAMGYDTCAMGGFSKEAYV--KE 168
Cdd:cd02136   70 -KVLGPWSWF--------DL--------------------------GAFLQNLMLAAHALGLGTCPQGALAGYPDVvrKE 114

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 515936869 169 FNVSGRYEPVMLISVGKaAKEAHKSNRFDIEEVSD 203
Cdd:cd02136  115 LGIPDDEELVCGIALGY-PDPDAPVNQFRTPREPL 148
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 9-168 1.42e-07

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 48.87  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   9 DILKERASVKEYDTThEMTKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKL-LPIAYNQKQISQASAVIAVLGDl 87
Cdd:cd20608    2 EAIKTRRSVRRFSDK-PVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSELaKKESPSNGWLKDAPVIIVVCAD- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  88 eanlkgekiyselaeqgfitediketlmTQINGAYQSEQYAREAaysnASLAAMQLMIAAKAMGYDTCAMGGFsKEAYVK 167
Cdd:cd20608   80 ----------------------------PKDSGWLNGQNYYLVD----AAIAMQNLMLAATDLGLGTCWIGAF-DEKKVK 126


                 .
gi 515936869 168 E 168
Cdd:cd20608  127 E 127
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 8-184 8.56e-07

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 46.83  E-value: 8.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869   8 IDILKERASVKEYDTTHEMTKEELTELLDITTKAPSAWNLQHWHFTVF-------------HSAESKAKLLPIAYNQKQI 74
Cdd:cd02135    1 LELIKTRRSIRKFKLTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVtgegrerlaellaAAAAARAPGADPEKLEKAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515936869  75 S---QASAVIAVLGDLEANLKGEKIyselaeqgfitediketlmtqingayqsEQYAreaaysnASLAAMQ-LMIAAKAM 150
Cdd:cd02135   81 EkalRAPVVIAVVAKPDEDPKVPEW----------------------------EQYA-------AVGAAVQnLLLAAHAL 125

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 515936869 151 GYDTC-AMGGFSKEAYVKE-FNVSGRYEPVMLISVG 184
Cdd:cd02135  126 GLGAVwRTGPVTYDPAVREaLGLPEDERIVGFLYLG 161
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 11-64 1.68e-04

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 40.92  E-value: 1.68e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 515936869  11 LKERASVKEY-DTTHEmtKEELTELLDITTKAPSAWNLQHWHFTVFHSAESKAKL 64
Cdd:cd02143    2 LRSRRSIRRYkDKPVP--RETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRL 54
McbC_SagB-like_oxidoreductase cd02142
oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain ...
 129-185 3.90e-03

oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides.


Pssm-ID: 380318  Cd Length: 200  Bit Score: 37.01  E-value: 3.90e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515936869 129 REAAYSN----ASLAAMQLMIAAKAMGYDTCAMGGFSKEAYVKEFNVSGRYEPVM-LISVGK 185
Cdd:cd02142  139 GERAYRYilleAGHLAQNLYLAATALGLGLCAIGAFDDDALRELLGLDEVEEVVLyAFVVGG 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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