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Conserved domains on  [gi|515803799|ref|WP_017234554|]
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hemolysin III family protein [Pandoraea sp. B-6]

Protein Classification

PAQR family membrane homeostasis protein( domain architecture ID 10003362)

PAQR family membrane homeostasis protein such as TrhA (transmembrane homeostasis protein A), a plasma membrane protein found in both Escherichia coli and Bacillus subtilis, that belongs to the PAQR family, named for eukaryotic Progestin and AdipoQ Receptors. PAQR family proteins in bacteria originally were named for a family member from Bacillus cereus that was named hemolysin III

Gene Ontology:  GO:0019835
TCDB:  1.C.113

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
4-214 2.91e-72

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 440883  Cd Length: 213  Bit Score: 218.09  E-value: 2.91e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   4 TGRAQTRGEELANSASHGIACMAALAATPALFTAVrPPLPNTGEQIGIGVFAITMVIVYLASALYHGLPDGRAKRLFMRV 83
Cdd:COG1272    3 TSAPYSRVEEIANAITHGIGALLAIAGLVVLIVLA-ALSGDAWAIVSFSIYGASLILLYLASTLYHSLPSPRAKRVLRRL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799  84 DHCAIFLFIAGTYTPFTVKILHDPWGWPLLTGVWAMAIAGLVAKGLGLLDRPLVSTLLYVGLGWIAVLVAGPVLAAIPGP 163
Cdd:COG1272   82 DHSAIYLLIAGTYTPFALIALRGPWGWTLLGIVWGLALLGIVLKLFFPGRPRWLSTLLYLAMGWLAVFAIPPLLAALPPA 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 515803799 164 GADWLYAGGVAYTVGALFYSLDgHIKFGHLVWHLFAIGGTACHFLAVYRYV 214
Cdd:COG1272  162 GLWLLLAGGLLYTVGAVFYALK-RLPGFHEIWHLFVLAGSACHFVAILLYV 211
 
Name Accession Description Interval E-value
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
4-214 2.91e-72

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 218.09  E-value: 2.91e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   4 TGRAQTRGEELANSASHGIACMAALAATPALFTAVrPPLPNTGEQIGIGVFAITMVIVYLASALYHGLPDGRAKRLFMRV 83
Cdd:COG1272    3 TSAPYSRVEEIANAITHGIGALLAIAGLVVLIVLA-ALSGDAWAIVSFSIYGASLILLYLASTLYHSLPSPRAKRVLRRL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799  84 DHCAIFLFIAGTYTPFTVKILHDPWGWPLLTGVWAMAIAGLVAKGLGLLDRPLVSTLLYVGLGWIAVLVAGPVLAAIPGP 163
Cdd:COG1272   82 DHSAIYLLIAGTYTPFALIALRGPWGWTLLGIVWGLALLGIVLKLFFPGRPRWLSTLLYLAMGWLAVFAIPPLLAALPPA 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 515803799 164 GADWLYAGGVAYTVGALFYSLDgHIKFGHLVWHLFAIGGTACHFLAVYRYV 214
Cdd:COG1272  162 GLWLLLAGGLLYTVGAVFYALK-RLPGFHEIWHLFVLAGSACHFVAILLYV 211
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
12-214 2.99e-43

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 144.00  E-value: 2.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   12 EELANSASHGIACMAALAATPALFTAVRPPLPNTgEQIGIGVFAITMVIVYLASALYHGLP-DGRAKRLFMRVDHCAIFL 90
Cdd:TIGR01065   1 EEIANAITHGIGAVLSIIALALLVIYSWDHGGAV-AVLGFSIYGISLILLFLVSTLYHSIPkGSKAKNWLRKIDHSMIYV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   91 FIAGTYTPFTVKILHDPWGWPLLTGVWAMAIAGLVAKGLGLLDRPLVSTLLYVGLGWIAVLVAGPVLAAIPGPGADWLYA 170
Cdd:TIGR01065  80 LIAGTYTPFLLLALPGPLGWTVLWIIWGLAIGGIIYKLFFHKRPRWLSLFLYLIMGWLVVLVIKPLYHNLPGAGFSLLAA 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 515803799  171 GGVAYTVGALFYSLDGHIKF-GHLVWHLFAIGGTACHFLAVYRYV 214
Cdd:TIGR01065 160 GGLLYTVGAIFYALKWPIPFtYHAIWHLFVLGASACHFVAILFYV 204
PRK15087 PRK15087
hemolysin; Provisional
12-214 7.88e-40

hemolysin; Provisional


Pssm-ID: 185044  Cd Length: 219  Bit Score: 135.60  E-value: 7.88e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799  12 EELANSASHGIACMAALAATPALFTAVRPPLPNTGEQIGIGVFAITMVIVYLASALYHGLPDGRAKRLFMRVDHCAIFLF 91
Cdd:PRK15087  15 EEIANSISHGIGLVFGIVGLVLLLVQAVDANADATAITSYSLYGGSMILLFLASTLYHAIPHQRAKRWLKKFDHCAIYLL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799  92 IAGTYTPFTVKILHDPWGWPLLTGVWAMAIAGLVAKGLGLLDRPLVSTLLYVGLGWIAVLVAGPVLAAIPGPGADWLYAG 171
Cdd:PRK15087  95 IAGTYTPFLLVGLDSPLARGLMIVIWSLALLGILFKLAFAHRFKVLSLVTYLAMGWLSLIVIYQLAIKLAIGGVTLLAVG 174
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 515803799 172 GVAYTVGALFYsLDGHIKFGHLVWHLFAIGGTACHFLAVYRYV 214
Cdd:PRK15087 175 GVVYSLGVIFY-VCKRIPYNHAIWHGFVLGGSVCHFLAIYLYV 216
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
12-207 4.40e-32

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 115.83  E-value: 4.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   12 EELANSASHGIACMAALAATPALFTAVRPPLPNTgEQIGIGVFAITMVIVYLASALYHGLP--DGRAKRLFMRVDHCAIF 89
Cdd:pfam03006   5 NETLNIWTHLLGAILFIALLIFLLALATIDSQLS-AVLPFLIFLLSACLCLGCSALYHTFSchSEKVRKLFRKLDYSGIF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   90 LFIAGTYTPFTVKIL--HDPWGWPLLTGVWAMAIAGLVAKGLGLLDRPL---VSTLLYVGLGWIAVLVAGPVLAAIPGPG 164
Cdd:pfam03006  84 LLIAGSYTPVIYYAFycAPKLGTIYLSFIWALAILGIISKLLWCFSKPAprwLRTAVYILMGWSGIIPIAHRALALGGAG 163
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 515803799  165 A------DWLYAGGVAYTVGALFYSLDGHIKF----------GHLVWHLFAIGGTACHF 207
Cdd:pfam03006 164 EaleialVLLVLGGVLYIIGAVFYALRVPERLfpgkfdivggSHQIFHVFVVLAALCHY 222
 
Name Accession Description Interval E-value
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
4-214 2.91e-72

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 218.09  E-value: 2.91e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   4 TGRAQTRGEELANSASHGIACMAALAATPALFTAVrPPLPNTGEQIGIGVFAITMVIVYLASALYHGLPDGRAKRLFMRV 83
Cdd:COG1272    3 TSAPYSRVEEIANAITHGIGALLAIAGLVVLIVLA-ALSGDAWAIVSFSIYGASLILLYLASTLYHSLPSPRAKRVLRRL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799  84 DHCAIFLFIAGTYTPFTVKILHDPWGWPLLTGVWAMAIAGLVAKGLGLLDRPLVSTLLYVGLGWIAVLVAGPVLAAIPGP 163
Cdd:COG1272   82 DHSAIYLLIAGTYTPFALIALRGPWGWTLLGIVWGLALLGIVLKLFFPGRPRWLSTLLYLAMGWLAVFAIPPLLAALPPA 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 515803799 164 GADWLYAGGVAYTVGALFYSLDgHIKFGHLVWHLFAIGGTACHFLAVYRYV 214
Cdd:COG1272  162 GLWLLLAGGLLYTVGAVFYALK-RLPGFHEIWHLFVLAGSACHFVAILLYV 211
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
12-214 2.99e-43

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 144.00  E-value: 2.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   12 EELANSASHGIACMAALAATPALFTAVRPPLPNTgEQIGIGVFAITMVIVYLASALYHGLP-DGRAKRLFMRVDHCAIFL 90
Cdd:TIGR01065   1 EEIANAITHGIGAVLSIIALALLVIYSWDHGGAV-AVLGFSIYGISLILLFLVSTLYHSIPkGSKAKNWLRKIDHSMIYV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   91 FIAGTYTPFTVKILHDPWGWPLLTGVWAMAIAGLVAKGLGLLDRPLVSTLLYVGLGWIAVLVAGPVLAAIPGPGADWLYA 170
Cdd:TIGR01065  80 LIAGTYTPFLLLALPGPLGWTVLWIIWGLAIGGIIYKLFFHKRPRWLSLFLYLIMGWLVVLVIKPLYHNLPGAGFSLLAA 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 515803799  171 GGVAYTVGALFYSLDGHIKF-GHLVWHLFAIGGTACHFLAVYRYV 214
Cdd:TIGR01065 160 GGLLYTVGAIFYALKWPIPFtYHAIWHLFVLGASACHFVAILFYV 204
PRK15087 PRK15087
hemolysin; Provisional
12-214 7.88e-40

hemolysin; Provisional


Pssm-ID: 185044  Cd Length: 219  Bit Score: 135.60  E-value: 7.88e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799  12 EELANSASHGIACMAALAATPALFTAVRPPLPNTGEQIGIGVFAITMVIVYLASALYHGLPDGRAKRLFMRVDHCAIFLF 91
Cdd:PRK15087  15 EEIANSISHGIGLVFGIVGLVLLLVQAVDANADATAITSYSLYGGSMILLFLASTLYHAIPHQRAKRWLKKFDHCAIYLL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799  92 IAGTYTPFTVKILHDPWGWPLLTGVWAMAIAGLVAKGLGLLDRPLVSTLLYVGLGWIAVLVAGPVLAAIPGPGADWLYAG 171
Cdd:PRK15087  95 IAGTYTPFLLVGLDSPLARGLMIVIWSLALLGILFKLAFAHRFKVLSLVTYLAMGWLSLIVIYQLAIKLAIGGVTLLAVG 174
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 515803799 172 GVAYTVGALFYsLDGHIKFGHLVWHLFAIGGTACHFLAVYRYV 214
Cdd:PRK15087 175 GVVYSLGVIFY-VCKRIPYNHAIWHGFVLGGSVCHFLAIYLYV 216
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
12-207 4.40e-32

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 115.83  E-value: 4.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   12 EELANSASHGIACMAALAATPALFTAVRPPLPNTgEQIGIGVFAITMVIVYLASALYHGLP--DGRAKRLFMRVDHCAIF 89
Cdd:pfam03006   5 NETLNIWTHLLGAILFIALLIFLLALATIDSQLS-AVLPFLIFLLSACLCLGCSALYHTFSchSEKVRKLFRKLDYSGIF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515803799   90 LFIAGTYTPFTVKIL--HDPWGWPLLTGVWAMAIAGLVAKGLGLLDRPL---VSTLLYVGLGWIAVLVAGPVLAAIPGPG 164
Cdd:pfam03006  84 LLIAGSYTPVIYYAFycAPKLGTIYLSFIWALAILGIISKLLWCFSKPAprwLRTAVYILMGWSGIIPIAHRALALGGAG 163
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 515803799  165 A------DWLYAGGVAYTVGALFYSLDGHIKF----------GHLVWHLFAIGGTACHF 207
Cdd:pfam03006 164 EaleialVLLVLGGVLYIIGAVFYALRVPERLfpgkfdivggSHQIFHVFVVLAALCHY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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