|
Name |
Accession |
Description |
Interval |
E-value |
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
1-432 |
0e+00 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 858.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 1 MVEKLTWKKLAWELAFFYAPWVLVGWIFGYLPWLLLAATVLQLGWHLHNQMRLSAWLWDEKRLTPPSGSGNWESLFNGIY 80
Cdd:PRK11006 1 MLERLSWKRLVLELALFCLPALILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLFYGLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 81 RMQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQD 160
Cdd:PRK11006 81 QMQLRNRKRRRELGNLIKRFRSGAESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEFTQYLKTRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 161 FSEPLEMpsPLNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMiVGP 240
Cdd:PRK11006 161 FSRPLTL--VLNNGRHLEIRVMPYTEGQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPL-EGA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 241 MWTKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSgDREHKLEFDIDKSLRVLADED 320
Cdd:PRK11006 238 LREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLS-QGKHTITFEVDNSLKVFGNED 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 321 QLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKH 400
Cdd:PRK11006 317 QLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKH 396
|
410 420 430
....*....|....*....|....*....|..
gi 515630247 401 ALSHHDSHLEIQSEVGVGSRFHFTLPNRLTVS 432
Cdd:PRK11006 397 ALSHHDSRLEIESEVGKGTRFSFVLPERLIAK 428
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
93-425 |
0e+00 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 542.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 93 LTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQDFSEPLEMPSPLN 172
Cdd:TIGR02966 1 LSALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEFVEYLAAGRFSEPLELPSPIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 173 VERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMIVGPMWTKAHGVMTEQ 252
Cdd:TIGR02966 81 SERVLEIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 253 LNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDREHKLEFDIDKSLRVLADEDQLRSAISNLVYN 332
Cdd:TIGR02966 161 SQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 333 AVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQ 412
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIE 320
|
330
....*....|...
gi 515630247 413 SEVGVGSRFHFTL 425
Cdd:TIGR02966 321 SELGKGSTFSFIF 333
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
171-426 |
4.95e-101 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 306.48 E-value: 4.95e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 171 LNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMIVGPMWTKAHGVMT 250
Cdd:COG5002 130 LLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIIL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 251 EQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDREHKLEFDI-DKSLRVLADEDQLRSAISNL 329
Cdd:COG5002 210 EEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpEDPLLVLGDPDRLEQVLTNL 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 330 VYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHL 409
Cdd:COG5002 290 LDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRI 369
|
250
....*....|....*..
gi 515630247 410 EIQSEVGVGSRFHFTLP 426
Cdd:COG5002 370 WVESEPGKGTTFTITLP 386
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
175-426 |
1.01e-70 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 226.33 E-value: 1.01e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 175 RMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPdmiVGPMWTKAHGVMTEQLN 254
Cdd:COG0642 79 LLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE---LDEEQREYLETILRSAD 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 255 RMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDREHKLEFDIDKSL-RVLADEDQLRSAISNLVYNA 333
Cdd:COG0642 156 RLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNA 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 334 VKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLEIQS 413
Cdd:COG0642 236 IKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVES 313
|
250
....*....|...
gi 515630247 414 EVGVGSRFHFTLP 426
Cdd:COG0642 314 EPGKGTTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
194-426 |
6.16e-70 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 220.93 E-value: 6.16e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 194 RDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMIVGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEAAP 273
Cdd:COG2205 4 EALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 274 MHELDEVVNVPAMLEVLEKEAASLSGDREHKLEFDID-KSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQ 352
Cdd:COG2205 84 LSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPpELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGD 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515630247 353 GACLDVSDTGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG2205 164 GVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-429 |
8.40e-55 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 177.39 E-value: 8.40e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 322 LRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHA 401
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*...
gi 515630247 402 LSHHDSHLEIQSEVGVGSRFHFTLPNRL 429
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
98-429 |
1.80e-52 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 182.87 E-value: 1.80e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPD---FIKYLNKQDFSEPL---EMPSPL 171
Cdd:COG5809 141 EKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDqenVAAFISQLLKDGGIaqgEVRFWT 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 172 NVERM--LELRIVPYTEGEH----LMVVRDVTQLKQLE-GMRRN--------FFANVSHELRTPMTVLQGYLEMTEDPDM 236
Cdd:COG5809 221 KDGRWrlLEASGAPIKKNGEvdgiVIIFRDITERKKLEeLLRKSeklsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTID 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 237 IVGPMWTkahGVMTEQLNRMNSLVNQLLTLSKIEAAPMHE--LDEVVNvpAMLEVLEKEAasLSGDREHKLEFDIDKSLr 314
Cdd:COG5809 301 EEQKTYL---DIMLSELDRIESIISEFLVLAKPQAIKYEPkdLNTLIE--EVIPLLQPQA--LLKNVQIELELEDDIPD- 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 315 VLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGAC-LDVSDTGDGIEPQHLHRLTERFYrvdkarSRDTGGSGL 393
Cdd:COG5809 373 ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVvISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGL 446
|
330 340 350
....*....|....*....|....*....|....*.
gi 515630247 394 GLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLPNRL 429
Cdd:COG5809 447 GLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKL 482
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
92-426 |
5.73e-52 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 180.16 E-value: 5.73e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 92 ELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQ-DFSEPLEMPSP 170
Cdd:COG5000 84 ELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREAlERGWQEEIELT 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 171 LNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGM-------RRnffanVSHELRTPMTVLQGYLE---------MTEDP 234
Cdd:COG5000 164 RDGRRTLLVRASPLRDDGYVIVFDDITELLRAERLaawgelaRR-----IAHEIKNPLTPIQLSAErlrrkladkLEEDR 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 235 DMIvgpmwTKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMheldEVVNVPAMLEvlekEAASL----SGDREHKLEFDID 310
Cdd:COG5000 239 EDL-----ERALDTIIRQVDRLKRIVDEFLDFARLPEPQL----EPVDLNELLR----EVLALyepaLKEKDIRLELDLD 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 311 KSL-RVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrvdkarSRDTG 389
Cdd:COG5000 306 PDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPK 379
|
330 340 350
....*....|....*....|....*....|....*..
gi 515630247 390 GSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG5000 380 GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
118-426 |
4.32e-51 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 181.49 E-value: 4.32e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 118 GNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDfikylnKQDFSEPLEMPSPLNVERMlelrivpyTEGEHLM------ 191
Cdd:NF033092 278 GRVILINDPALEMLNVSRETVLGQSILDVLGLEE------EYTLRDLLEEQDSLLLDFS--------TEEEPLIlranfs 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 192 --------------VVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMT-----EDPDmiVGPmwtKAHGVMTEQ 252
Cdd:NF033092 344 viqresgfingliaVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALadgawKDPE--LAP---RFLGVTQNE 418
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 253 LNRMNSLVNQLLTLSKIEAAPMhELD-EVVNVPAML-EVLekeaaslsgDR------EHKLEFDID---KSLRVLADEDQ 321
Cdd:NF033092 419 TERMIRLVNDLLQLSRMDSKDY-KLNkEWVNFNEFFnYII---------DRfemilkNKNITFKREfpkRDLWVEIDTDK 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 322 LRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHA 401
Cdd:NF033092 489 ITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEV 568
|
330 340
....*....|....*....|....*
gi 515630247 402 LSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:NF033092 569 VEAHGGRIWAESEEGKGTTIYFTLP 593
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
92-426 |
2.65e-50 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 173.88 E-value: 2.65e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 92 ELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPD-FIKYL-----NKQDFSEP- 164
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSpLRELLeralaEGQPVTERe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 165 LEMPSPLNVERMLELRIVPYTEGEH----LMVVRDVTQLKQLEG-MRRN--------FFANVSHELRTPMTVLQGYLEM- 230
Cdd:COG3852 81 VTLRRKDGEERPVDVSVSPLRDAEGeggvLLVLRDITERKRLEReLRRAeklaavgeLAAGLAHEIRNPLTGIRGAAQLl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 231 ------TEDPDMIvgpmwtkahGVMTEQLNRMNSLVNQLLTLSKIEAAPMheldEVVNVPAMLE----VLEKEAAslsgd 300
Cdd:COG3852 161 erelpdDELREYT---------QLIIEEADRLNNLVDRLLSFSRPRPPER----EPVNLHEVLErvleLLRAEAP----- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 301 REHKLEFDIDKSL-RVLADEDQLRSAISNLVYNAVKYTPPGATVKVR----------WYQTSQGACLDVSDTGDGIEPQH 369
Cdd:COG3852 223 KNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRtrverqvtlgGLRPRLYVRIEVIDNGPGIPEEI 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 515630247 370 LHRLTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG3852 303 LDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
105-426 |
6.61e-39 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 147.81 E-value: 6.61e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 105 ESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNL-IRTPDFIKYL------NKQDFSEPLEMPSPlnvERML 177
Cdd:PRK11360 269 ESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELfPPNTPFASPLldtlehGTEHVDLEISFPGR---DRTI 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 178 EL----RIVPYTEGE---HLMVVRDVTQLKQL-EGMRR--------NFFANVSHELRTPMTVLQGYLEMTEDPDMivGPM 241
Cdd:PRK11360 346 ELsvstSLLHNTHGEmigALVIFSDLTERKRLqRRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTS--DPP 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 242 WTKAHGVMTEQLNRMNSLVNQLLTLSKieaaPMHEldevVNVPAMLEVLEKEAASLSGDREHK----LEFDIDKSL-RVL 316
Cdd:PRK11360 424 SQEYLSVVLREVDRLNKVIDQLLEFSR----PRES----QWQPVSLNALVEEVLQLFQTAGVQarvdFETELDNELpPIW 495
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 317 ADEDQLRSAISNLVYNAVKYTPPGATVKVR-WYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVdKARsrdtgGSGLGL 395
Cdd:PRK11360 496 ADPELLKQVLLNILINAVQAISARGKIRIRtWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTT-KAK-----GTGLGL 569
|
330 340 350
....*....|....*....|....*....|.
gi 515630247 396 AIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK11360 570 ALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
199-426 |
7.09e-39 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 145.61 E-value: 7.09e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 199 LKQLE-GMRR--NFFANVSHELRTPMTVL--QGYLEMTEDPDmivGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIE--- 270
Cdd:TIGR01386 231 LGRLEdAFQRlsQFSADLAHELRTPLTNLlgQTQVALSQPRT---GEEYREVLESNLEELERLSRMVSDMLFLARADngq 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 271 -AAPMHELD---EVVNVPAMLEVLEKEAAslsgdrehkLEFDIDKSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVR 346
Cdd:TIGR01386 308 lALERVRLDlaaELAKVAEYFEPLAEERG---------VRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVR 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 347 WYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGvGSRFHFTLP 426
Cdd:TIGR01386 379 IERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG-KTRFILRFP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
210-426 |
2.87e-37 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 142.23 E-value: 2.87e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 210 FAN-VSHELRTPMTVLQGYLEMTE-------DPDmivgpmwTKAH-GVMTEQLNRMNSLVNQLLTLSKIEAAPMHEldEV 280
Cdd:COG4251 285 FAYvASHDLREPLRKISGFSQLLEedygdklDEE-------GREYlERIRDAAERMQALIDDLLAYSRVGRQELEF--EP 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 281 VNVPAML-EVLEKEAASLsgdREHKLEFDIDKSLRVLADEDQLRSAISNLVYNAVKYTPPG--ATVKVRWYQTSQGACLD 357
Cdd:COG4251 356 VDLNELLeEVLEDLEPRI---EERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFS 432
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515630247 358 VSDTGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG4251 433 VRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
105-426 |
1.99e-36 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 139.48 E-value: 1.99e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 105 ESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPD--FIKYLNKQDFSEPLEMPSPLNV------ERM 176
Cdd:COG5805 164 ENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDkeEFKERIESITEVWQEFIIEREIitkdgrIRY 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 177 LELRIVPY--TEGEH---LMVVRDVTQLKQLEGMRRNF---------FANVSHELRTPMTVLQGYLEMtedpdMIVGPMW 242
Cdd:COG5805 244 FEAVIVPLidTDGSVkgiLVILRDITEKKEAEELMARSeklsiagqlAAGIAHEIRNPLTSIKGFLQL-----LQPGIED 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 243 TKAHG-VMTEQLNRMNSLVNQLLTLSKieaaPMHELDEVVNVPAMLE----VLEKEAaSLSGDrehKLEFD-IDKSLRVL 316
Cdd:COG5805 319 KEEYFdIMLSELDRIESIISEFLALAK----PQAVNKEKENINELIQdvvtLLETEA-ILHNI---QIRLElLDEDPFIY 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 317 ADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrvdkarSRDTGGSGLGLA 396
Cdd:COG5805 391 CDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLM 464
|
330 340 350
....*....|....*....|....*....|
gi 515630247 397 IVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG5805 465 VSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
180-426 |
8.98e-36 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 137.27 E-value: 8.98e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 180 RIVPYTEGEHLMVVRDVTQLKQL----EGMRRNFFANVSHELRTPMTVLQGYLEMTED------PDMIVGpmwtkahgvM 249
Cdd:NF012163 210 RVTPTSNDELGKLAQDFNQLASTleknEQMRRDFMADISHELRTPLAVLRAELEAIQDgirkftPESLDS---------L 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 250 TEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDREHKLEFDIDKSLRVLADEDQLRSAISNL 329
Cdd:NF012163 281 QAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNL 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 330 VYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI-VKHALSHHDSH 408
Cdd:NF012163 361 LENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAIsLNIVQAHGGTL 440
|
250
....*....|....*...
gi 515630247 409 LEIQSEVGvGSRFHFTLP 426
Cdd:NF012163 441 HAAHSPLG-GLRIVVTLP 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
317-426 |
2.19e-35 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 126.61 E-value: 2.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 317 ADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKaRSRDTGGSGLGLA 396
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|
gi 515630247 397 IVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
208-428 |
2.43e-33 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 130.66 E-value: 2.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 208 NFFANVSHELRTPMTVLQGYLEMT--------EDPDMIVGPMwtkahgvmtEQLNRMNSLVNQLLTLSK-------IEAA 272
Cdd:PRK09835 264 NFSADIAHEIRTPITNLITQTEIAlsqsrsqkELEDVLYSNL---------EELTRMAKMVSDMLFLAQadnnqliPEKK 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 273 PMHELDEVVNVPAMLEVLEKEaaslsgdREHKLEFDiDKSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQ 352
Cdd:PRK09835 335 MLDLADEVGKVFDFFEAWAEE-------RGVELRFV-GDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDH 406
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515630247 353 GACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVgVGSRFHFTLPNR 428
Cdd:PRK09835 407 QVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLPRL 481
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
211-426 |
1.45e-32 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 126.45 E-value: 1.45e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 211 ANVSHELRTPMTVLQGYLEMTED--PDMIVGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELD--EVVNvpAM 286
Cdd:COG4191 147 AGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDlnELID--EA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 287 LEVLEKEAaslsGDREHKLEFDIDKSL-RVLADEDQLRSAISNLVYNAVKYTPPGA--TVKVRWYQTSQGACLDVSDTGD 363
Cdd:COG4191 225 LELLRPRL----KARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRREGDYVVISVRDNGP 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515630247 364 GIEPQHLHRLTERFY---RVDKarsrdtgGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG4191 301 GIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
194-428 |
3.36e-30 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 122.06 E-value: 3.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 194 RDVTQLKQLEGMRRNFFANVSHELRTPMTVLQgyleMTED------PDMivGPMWTKAHGVMTEQLNRMNSLVNQLLTLS 267
Cdd:NF040691 259 RQIRQLEELSRLQQRFVSDVSHELRTPLTTIR----MAADvihdsrDDF--DPATARSAELLHTELDRFESLLSDLLEIS 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 268 KIEA-APMHELDEVVNVPAMLEVLEkEAASLSGDREHKLEFDI-DKSLRVLADEDQLRSAISNLVYNAVKYTpPGATVKV 345
Cdd:NF040691 333 RFDAgAAELDVEPVDLRPLVRRVVD-ALRQLAERAGVELRVDApGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVV 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 346 RWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTL 425
Cdd:NF040691 411 TVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTL 490
|
...
gi 515630247 426 PNR 428
Cdd:NF040691 491 PRV 493
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
199-426 |
2.93e-29 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 118.97 E-value: 2.93e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 199 LKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDpdmivgpmwtkahGVMTEQLNRMNSLVNQLLTLSKIeAAPMHEL- 277
Cdd:PRK10549 233 LEKNEQMRRDFMADISHELRTPLAVLRGELEAIQD-------------GVRKFTPESVASLQAEVGTLTKL-VDDLHQLs 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 278 --DE--------VVNVPAMLEVlekEAASLSG---DREHKLEFDIDKSLRVLADEDQLRSAISNLVYNAVKYTPPGATVK 344
Cdd:PRK10549 299 lsDEgalayrktPVDLVPLLEV---AGGAFRErfaSRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLH 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 345 VRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQ-SEVGvGSRFHF 423
Cdd:PRK10549 376 ISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITV 454
|
...
gi 515630247 424 TLP 426
Cdd:PRK10549 455 ELP 457
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
4.08e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 109.86 E-value: 4.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 318 DEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI 397
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 515630247 398 V-KHALSHHDSHLEIQSEVGvGSRFHFTLP 426
Cdd:cd16946 81 ChNIALAHGGTISAEHSPLG-GLRLVLTLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
317-426 |
4.27e-29 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 109.77 E-value: 4.27e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 317 ADEDQLRSAISNLVYNAVKYTPPGATVKVRwYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKarsRDTGGSGLGLA 396
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 515630247 397 IVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
322-426 |
1.64e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 105.27 E-value: 1.64e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 322 LRSAISNLVYNAVKYTPPGA-TVKVRWYQTSQGA---CLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI 397
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 515630247 398 VKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PhoR |
pfam11808 |
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members ... |
7-83 |
1.83e-26 |
|
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members include PhoR. A member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR is the bifunctional histidine autokinase/phospho-PhoB phosphatase that donates a phosphoryl group to PhoB when environmental Pi is limiting and removes the phosphoryl group from phosphorylated PhoB (PhoB-P) when environmental Pi is abundant.
Pssm-ID: 432090 Cd Length: 84 Bit Score: 101.53 E-value: 1.83e-26
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515630247 7 WKKLAWELAFFYAPWVLVGWIFGYLPWLLLAATVLQLGWHLHNQMRLSAWLWDEKRLTPPSGSGNWESLFNGIYRMQ 83
Cdd:pfam11808 1 WRRLLWRLALLLLPALLLGLLFGHLAAALLLALLAYLAWHLYQLLRLSRWLWRPRKLTPPDGSGLWGEIFYGLYRLQ 77
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
215-428 |
6.55e-26 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 109.55 E-value: 6.55e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 215 HELRTPMTVLQGYLE-MTEDPdmivgPMWTKAH--GVMTEQLNRMNSLVNQLLTLSKIEAapMHELDEV--VNVPAML-E 288
Cdd:PRK11100 265 HELKSPLAAIRGAAElLQEDP-----PPEDRARftGNILTQSARLQQLIDRLLELARLEQ--RQELEVLepVALAALLeE 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 289 VLEKEAASLSGdREHKLEFDIDkSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQ 368
Cdd:PRK11100 338 LVEAREAQAAA-KGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDY 415
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515630247 369 HLHRLTERFY---RVDKARSrdtgGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLPNR 428
Cdd:PRK11100 416 ALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
92-426 |
5.05e-25 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 105.70 E-value: 5.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 92 ELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFrwpDDSGQPISNLIRtpdfiKYLNKQDFSEPLEMPspl 171
Cdd:COG3290 78 EIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLA-----EVLETGERDEEILLN--- 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 172 nvERMLELRIVPYTEGEHLM----VVRDVTQLK----QLEGMRRnfFANV----SHELRTPMTVLQGYLEMtEDPDmivg 239
Cdd:COG3290 147 --GRVLVVNRVPIRDDGRVVgavaTFRDRTELErleeELEGVKE--LAEAlraqRHDFRNHLHTISGLLQL-GEYD---- 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 240 pmwtKAHGVMTEQLNRMNSLVNQLLTLSKieaapmhelDEVVNvpAMLEVLEKEAAslsgDREHKLEFDIDKSLRVLA-D 318
Cdd:COG3290 218 ----EALEYIDEISEELQELIDSLLSRIG---------NPVLA--ALLLGKAARAR----ERGIDLTIDIDSDLPDLPlS 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 319 EDQLRSAISNLVYNAV----KYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRvdkarSRDTGGSGLG 394
Cdd:COG3290 279 DTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRGLG 353
|
330 340 350
....*....|....*....|....*....|..
gi 515630247 395 LAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG3290 354 LALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
211-426 |
4.87e-24 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 103.02 E-value: 4.87e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 211 ANVSHELRTPMTVLQGYLEMTEDPDmivgPMWTKA---HGVMTEQLNRMNSLVNQLLTLSKieaaPMHELDEVVNVPAML 287
Cdd:COG5806 206 ASIAHEVRNPLTVVRGFIQLLQEPE----LSDEKRkqyIRIALEELDRAEAIITDYLTFAK----PQPEKLEKIDVSEEL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 288 EVLEKEAASLSGDREHKLEFDIDKSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEP 367
Cdd:COG5806 278 EHVIDVLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTK 357
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 515630247 368 QHLHRLTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG5806 358 EQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
212-430 |
2.53e-23 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 101.22 E-value: 2.53e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 212 NVSHELRTPMTVLQGYLEMTEDPDMivgpmwtkahgvmTEQ--LNR----MNSLVNQLLTLSKIEAaPMHELD-EVVNVP 284
Cdd:PRK10604 218 GIAHELRTPLVRLRYRLEMSDNLSA-------------AESqaLNRdigqLEALIEELLTYARLDR-PQNELHlSEPDLP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 285 AMLEVLEKEAASLSGDREhkleFDIDKSLRVL---ADEDQLRSAISNLVYNAVKYTppGATVKVRWYQTSQGACLDVSDT 361
Cdd:PRK10604 284 AWLSTHLADIQAVTPEKT----VRLDTPHQGDygaLDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDD 357
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 362 GDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEI-QSEVGvGSRFHFTLPNRLT 430
Cdd:PRK10604 358 GPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCdESELG-GARFSFSWPVWHN 426
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
4.53e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 93.16 E-value: 4.53e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 322 LRSAISNLVYNAVKYTPpgATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHA 401
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 515630247 402 LSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
207-412 |
4.18e-22 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 96.96 E-value: 4.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 207 RNFFANVSHELRTPMTVLQGYLEMTEdpdmivgpmwtKAHGV----MTEQLNRMNSLVNQLLTLSKIEAA-------PMH 275
Cdd:PRK10755 138 RLFTADVAHELRTPLAGIRLHLELLE-----------KQHHIdvapLIARLDQMMHTVEQLLQLARAGQSfssghyqTVK 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 276 ELDEVVnVPAMLEVLEKEAAslsgdREHKLEFDIDKS-LRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGA 354
Cdd:PRK10755 207 LLEDVI-LPSQDELSEMLEQ-----RQQTLLLPESAAdITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGA 280
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 515630247 355 CLDVSDTGDGIEPQHLHRLTERFYRVDkarSRdTGGSGLGLAIVKHALSHHDSHLEIQ 412
Cdd:PRK10755 281 VLAVEDEGPGIDESKCGELSKAFVRMD---SR-YGGIGLGLSIVSRITQLHHGQFFLQ 334
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
312-420 |
5.38e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 90.54 E-value: 5.38e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 312 SLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRwYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKarsRDTGGS 391
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGS 79
|
90 100
....*....|....*....|....*....
gi 515630247 392 GLGLAIVKHALSHHDSHLEIQSEVGVGSR 420
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNAQGGGLE 108
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
193-427 |
7.19e-22 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 97.29 E-value: 7.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 193 VRDVTQ--------LKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDmivgpmwtkahGVMTEQLNR----MNSLV 260
Cdd:PRK09467 208 VRSVTRafnqmaagIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMSEED-----------GYLAESINKdieeCNAII 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 261 NQLLT-LSKIEAAPMHELDevvnvpamLEVLEKEAASLSGDREHKLEFDI-DKSLRVLADEDQLRSAISNLVYNAVKYTp 338
Cdd:PRK09467 277 EQFIDyLRTGQEMPMEMAD--------LNALLGEVIAAESGYEREIETALqPGPIEVPMNPIAIKRALANLVVNAARYG- 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 339 pGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALSHHDSHLEIQ--SEVG 416
Cdd:PRK09467 348 -NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELGnsEEGG 424
|
250
....*....|.
gi 515630247 417 VGSRFHFTLPN 427
Cdd:PRK09467 425 LSARAWLPLTT 435
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
189-410 |
1.03e-21 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 96.64 E-value: 1.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 189 HLMVVRDvtqlkqlegmrRNFFANVSHELRTPMTVLQGYLEMTE----DPDMivgpmWTKAHGVMTEQLNRMNSLVNQLL 264
Cdd:PRK10337 231 HAMMVRE-----------RRFTSDAAHELRSPLAALKVQTEVAQlsddDPQA-----RKKALLQLHAGIDRATRLVDQLL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 265 TLSKIEAapMHELDEVVNVPamlevLEKEAASLSGDREHKLE-FDIDKSLRvLADEDQLRSA--------ISNLVYNAVK 335
Cdd:PRK10337 295 TLSRLDS--LDNLQDVAEIP-----LEDLLQSAVMDIYHTAQqAGIDVRLT-LNAHPVIRTGqplllsllVRNLLDNAIR 366
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515630247 336 YTPPGATVKVrwyqTSQGACLDVSDTGDGIEPQHLHRLTERFYRvdkARSRDTGGSGLGLAIVKHALSHHDSHLE 410
Cdd:PRK10337 367 YSPQGSVVDV----TLNARNFTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVS 434
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
178-426 |
6.79e-21 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 95.39 E-value: 6.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 178 ELRIVPY--TEGEHLMVV---RDVTQLKQ----LEGMRRN---FFANVSHELRTPMTVLQGYLEMTEDPDMivgpmwtka 245
Cdd:PRK11091 243 ELRKVPFydRVGKRHGLMgfgRDITERKRyqdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLDTEL--------- 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 246 hgvMTEQLNRMNS----------LVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDREHKLEFDIDKSL-- 313
Cdd:PRK11091 314 ---TAEQRKYLKTihvsaitlgnIFNDIIDMDKMERRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPLph 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 314 RVLADEDQLRSAISNLVYNAVKYTPPGaTVKVR-WYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRV-DKARSRDTGGS 391
Cdd:PRK11091 391 KVITDGTRLRQILWNLISNAVKFTQQG-GVTVRvRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGT 469
|
250 260 270
....*....|....*....|....*....|....*
gi 515630247 392 GLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK11091 470 GIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
211-426 |
7.63e-21 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 93.48 E-value: 7.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 211 ANVSHELRTPMT----VLQGYLEMTEDPDMIVGP-MWTKAHGVMTEQLNRMNSLVNQLLTLSKI--EAAPMHElDEVVNV 283
Cdd:PRK09303 156 AMLAHDLRTPLTaaslALETLELGQIDEDTELKPaLIEQLQDQARRQLEEIERLITDLLEVGRTrwEALRFNP-QKLDLG 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 284 PAMLEVLEKEAASLSGdREHKLEFDIDKSL-RVLADEDQLRSAISNLVYNAVKYTPPGATVKVR-WYQTSQGACLDVSDT 361
Cdd:PRK09303 235 SLCQEVILELEKRWLA-KSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSmLHRTTQKVQVSICDT 313
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515630247 362 GDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK09303 314 GPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
209-426 |
2.92e-20 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 93.69 E-value: 2.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 209 FFANVSHELRTPMTVLQGYLEMTEDPdmivgpmwtkahGVMTEQ---LNRMN-------SLVNQLLTLSKIEAA-----P 273
Cdd:TIGR02956 467 FLATMSHEIRTPLNGILGTLELLGDT------------GLTSQQqqyLQVINrsgesllDILNDILDYSKIEAGhlsisP 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 274 MH-ELDEVVNVPAMLEVLEKEAASLSgdrehkLEFDIDKSLR--VLADEDQLRSAISNLVYNAVKYTPPGA-TVKVRWYQ 349
Cdd:TIGR02956 535 RPfDLNALLDDVHHLMVSRAQLKGIQ------LRLNIPEQLPnwWQGDGPRIRQVLINLVGNAIKFTDRGSvVLRVSLND 608
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515630247 350 TSQGAcLDVSDTGDGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:TIGR02956 609 DSSLL-FEVEDTGCGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
211-426 |
3.40e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 93.55 E-value: 3.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 211 ANVSHELRTPMTVLQGYLEMTEDpdmivGPMWTKAHGVMTEQLNRMNSL---VNQLLTLSKIEAAPMH-ELDEVVNVP-- 284
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQN-----TPLTAEQMDLADTARQCTLSLlaiINNLLDFSRIESGQMTlSLEETALLPll 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 285 --AML----EVLEKEAA--SLSGDrEHKLEFDIDkSLRvladedqLRSAISNLVYNAVKYTPPGA---TVKVRwyqtSQG 353
Cdd:PRK15347 478 dqAMLtiqgPAQSKSLTlrTFVGA-HVPLYLHLD-SLR-------LRQILVNLLGNAVKFTETGGirlRVKRH----EQQ 544
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515630247 354 ACLDVSDTGDGIEPQHLHRLTERFYRVDKarsrDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK15347 545 LCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
211-426 |
4.55e-20 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 90.82 E-value: 4.55e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 211 ANVSHELRTPMTVLQGYLEMTEDpdmivgpmwtkahGVMTEQLNRMNSLVNQ----------LLTLSKIEAAPMHELDEV 280
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILD-------------GVFEPDPALFKSLLNQveglshlvedLRTLSLVENQQLRLNYES 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 281 VNvpaMLEVLEKeAASLSGDREHK----LEFDIDKSLrVLADEDQLRSAISNLVYNAVKYTPPGaTVKVRWYQTSQGACL 356
Cdd:NF012226 210 VD---LKDSIEK-VLKMFEDRLEQaqltIVLNLTATP-VFCDRRRIEQVLIALIDNAIRYANAG-KLKISSSVIQDDWIL 283
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 357 DVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGvGSRFHFTLP 426
Cdd:NF012226 284 QIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQG-NSVFTIKLP 352
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
213-405 |
1.28e-19 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 90.76 E-value: 1.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 213 VSHELRTPMTVLQgylemtedpdMIVGPMwTKAHGVMTE------QLNRMNSLVNQLLTLSKI--------EAAPMHEL- 277
Cdd:PRK09470 250 ISHELRTPLTRLQ----------LATALL-RRRQGESKElerietEAQRLDSMINDLLVLSRNqqknhlerETFKANSLw 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 278 DEVvnvpamLEVLEKEAaslsgdrEHKlefdiDKSLRVLADEDQ---------LRSAISNLVYNAVKYTppGATVKVRWY 348
Cdd:PRK09470 319 SEV------LEDAKFEA-------EQM-----GKSLTVSAPPGPwpingnpnaLASALENIVRNALRYS--HTKIEVAFS 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 515630247 349 QTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHH 405
Cdd:PRK09470 379 VDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQH 435
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
203-426 |
1.82e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 91.25 E-value: 1.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 203 EGMRRNFFANVSHELRTPMTVLQGYLEM-TEDPDMIVGPMWTKAHGVMTEQLNrMNSLVNQLLTLSKIEAAPMH------ 275
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEIlTLDLASEGSPHARQASEIRQQVLN-TTRLVNNLLDMARIQSGGFNlrkewl 739
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 276 ELDEVVNvpAMLEVLEkeaASLSGdreHKLEFDIDKSLRVL-ADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGA 354
Cdd:PRK10490 740 TLEEVVG--SALQMLE---PGLSG---HPINLSLPEPLTLIhVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERL 811
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515630247 355 CLDVSDTGDGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK10490 812 QLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
1.88e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 83.15 E-value: 1.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 322 LRSAISNLVYNAVKYTPPGAT--VKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDkarSRDT-GGSGLGLAIV 398
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEyEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 515630247 399 KHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
1.17e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 80.89 E-value: 1.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 322 LRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKarSRDTGGSGLGLAIVKHA 401
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 515630247 402 LSHHDSHLEIQSEvGVGSRFHFTLP 426
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
211-426 |
1.72e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 87.15 E-value: 1.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 211 ANVSHELRTPMTVLQGYLEMTEDPdmivGPMWTKAHG---VMTEQLNRMNSLVNQLLTLSKieaaPMHELDEVVNVPAM- 286
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAER----APAGGEAHQlaqVMAKEADRLNRVVSELLELVK----PTHLALQAVDLNDLi 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 287 ---LEVLEKEAASlsgdREHKLEFDIDKSL-RVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTG 362
Cdd:PRK10364 314 nhsLQLVSQDANS----REIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSG 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515630247 363 DGIEPQHLHRLTERFYrVDKARsrdtgGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK10364 390 KGIAADQLEAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
318-426 |
3.07e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 79.84 E-value: 3.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 318 DEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACL-DVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLA 396
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLlTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 515630247 397 IVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
8.61e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 78.26 E-value: 8.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 322 LRSAISNLVYNAVKYTppGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKArsRDTGGSGLGLAIVKHA 401
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNA--RGTSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 515630247 402 LSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
213-426 |
2.95e-17 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 84.34 E-value: 2.95e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 213 VSHELRTPMTVLQGYLEMTEDPdmivgpmwTKAHGVMTEQL-------NRMNSLVNQLLTLSKIEAAPMH--ELDEVVNV 283
Cdd:PRK13837 457 IAHNFNNILGAILGYAEMALNK--------LARHSRAARYIdeiisagARARLIIDQILAFGRKGERNTKpfDLSELVTE 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 284 PAMLEvlekeAASLSGDREHKLEFDiDKSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQT--------SQG-- 353
Cdd:PRK13837 529 IAPLL-----RVSLPPGVELDFDQD-QEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAklrapkvlSHGvl 602
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515630247 354 -----ACLDVSDTGDGIEPQHLHRLTERFYrvdKARSrdtGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK13837 603 ppgryVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
205-271 |
3.02e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.71 E-value: 3.02e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515630247 205 MRRNFFANVSHELRTPMTVLQGYLEMTEDPDmiVGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEA 271
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEK--LDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
3.68e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 74.00 E-value: 3.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 325 AISNLVYNAVKYtppgATVKVRWYQTSQG--ACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHAL 402
Cdd:cd16939 4 ALDNLLRNALRY----AHRTVRIALLVSGgrLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....*
gi 515630247 403 SHHDSHLEI-QSEVGvGSRFHFTLP 426
Cdd:cd16939 80 LWHGGHVECdDSELG-GACFRLTWP 103
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
205-271 |
5.75e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 71.83 E-value: 5.75e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515630247 205 MRRNFFANVSHELRTPMTVLQGYLEMTEDPDMivGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEA 271
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTEL--SEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
209-426 |
2.19e-15 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 78.48 E-value: 2.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 209 FFANVSHELRTPMTVLQGYLEM------TEDPDMIVGPMwtkahgvmteqlNRMNSL----VNQLLTLSKIEA------- 271
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLlqtkelPKGVDRLVTAM------------NNSSSLllkiISDILDFSKIESeqlkiep 517
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 272 ---APMheldEVVN--VPAMLEVLEKEAASLSGDREHklefDIDKSLRvlADEDQLRSAISNLVYNAVKYTPPGATVkVR 346
Cdd:PRK10841 518 refSPR----EVINhiTANYLPLVVKKRLGLYCFIEP----DVPVALN--GDPMRLQQVISNLLSNAIKFTDTGCIV-LH 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 347 WYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK10841 587 VRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-412 |
2.31e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.72 E-value: 2.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 322 LRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTgGSGLGLAIVKHA 401
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEV 83
|
90
....*....|.
gi 515630247 402 LSHHDSHLEIQ 412
Cdd:cd16945 84 AQLHGGRITLR 94
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
4.56e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 70.78 E-value: 4.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 318 DEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARsRDTGGSGLGLAI 397
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 515630247 398 VKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
185-426 |
9.80e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 76.70 E-value: 9.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 185 TEGEHLMVVRDVTQLKQLEGM--RRNFFANVSHELRTPMTVLQGYLEMtedpdmIVGPMWTKAHGVMTEQL-----NRMN 257
Cdd:PRK09959 689 TETRDLIHALEVERNKAINATvaKSQFLATMSHEIRTPISSIMGFLEL------LSGSGLSKEQRVEAISLayatgQSLL 762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 258 SLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDREHKLEFD--IDKSLRVLADEDQLRSAISNLVYNAVK 335
Cdd:PRK09959 763 GLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSstFPDHYLVKIDPQAFKQVLSNLLSNALK 842
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 336 YTPPGA----TVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDtgGSGLGLAIVKHALSHHDSHLEI 411
Cdd:PRK09959 843 FTTEGAvkitTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSL 920
|
250
....*....|....*
gi 515630247 412 QSEVGVGSRFHFTLP 426
Cdd:PRK09959 921 ESHPGIGTTFTITIP 935
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
209-430 |
1.94e-14 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 75.66 E-value: 1.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 209 FFANVSHELRTPMTVLQGYLEMTedpdmivgpMWTKAHGVMTEQLNRM----NSL---VNQLLTLSKIEAAPM------- 274
Cdd:PRK11107 296 FLANMSHELRTPLNGVIGFTRQT---------LKTPLTPTQRDYLQTIersaNNLlaiINDILDFSKLEAGKLvlenipf 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 275 --HE-LDEVVNVPAmlevlekeaaslSGDREHKLEF--DIDKSL--RVLADEDQLRSAISNLVYNAVKYTPPGAtVKVRW 347
Cdd:PRK11107 367 slREtLDEVVTLLA------------HSAHEKGLELtlNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESGN-IDILV 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 348 YQTSQGA------ClDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRF 421
Cdd:PRK11107 434 ELRALSNtkvqleV-QIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTF 512
|
....*....
gi 515630247 422 HFTLPNRLT 430
Cdd:PRK11107 513 WFHLPLDLN 521
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
205-268 |
3.59e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 66.85 E-value: 3.59e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515630247 205 MRRNFFANVSHELRTPMTVLQGYLEMTEDpDMIVGPMWTKAHGVMTEQLNRMNSLVNQLLTLSK 268
Cdd:cd00082 3 AKGEFLANVSHELRTPLTAIRGALELLEE-ELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
105-413 |
2.08e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 70.88 E-value: 2.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 105 ESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDfikyLNKQDFSEPLEMPSPL----------NVE 174
Cdd:PRK11073 14 NSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFS----LNIELMRESLQAGQGFtdnevtlvidGRS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 175 RMLELRIVPYTEGEHLMVVRDVTQLKQL---------EGMRRNFFANVSHELRTPMTVLQGYLEMTED--PDmivgPMWT 243
Cdd:PRK11073 90 HILSLTAQRLPEGMILLEMAPMDNQRRLsqeqlqhaqQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKalPD----PALT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 244 KAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASlsgdrehKLEFDIDKSLRVLA-DEDQL 322
Cdd:PRK11073 166 EYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIHKVAERVVQLVSLELPDNV-------RLIRDYDPSLPELAhDPDQI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 323 RSAISNLVYNAVK-YTPPGATVKVRW---YQ-TSQG------ACLDVSDTGDGIEPQHLHRLterFYRVDKARSrdtGGS 391
Cdd:PRK11073 239 EQVLLNIVRNALQaLGPEGGTITLRTrtaFQlTLHGeryrlaARIDIEDNGPGIPPHLQDTL---FYPMVSGRE---GGT 312
|
330 340
....*....|....*....|..
gi 515630247 392 GLGLAIVKHALSHHDSHLEIQS 413
Cdd:PRK11073 313 GLGLSIARNLIDQHSGKIEFTS 334
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
321-426 |
2.83e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 65.52 E-value: 2.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 321 QLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSrdtgGSGLGLAIVKH 400
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 515630247 401 ALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
304-425 |
4.19e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 66.00 E-value: 4.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 304 KLEFDI-DKSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDK 382
Cdd:cd16947 2 QVEINIpDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLED 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 515630247 383 ARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTL 425
Cdd:cd16947 82 SRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
209-428 |
6.72e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 70.70 E-value: 6.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 209 FFANVSHELRTPMTVLQGYLEMTEDPDMIvgPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHEL--DEVVNVPAM 286
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLADNPAL--NAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSvsDEPFEPRPL 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 287 LEVLEKEAASLSGDREHKLEFDIDKSL--RVLADEDQLRSAISNLVYNAVKYTPPGATVkVRWYQTSQGACLDVSDTGDG 364
Cdd:PRK11466 525 LESTLQLMSGRVKGRPIRLATDIADDLptALMGDPRRIRQVITNLLSNALRFTDEGSIV-LRSRTDGEQWLVEVEDSGCG 603
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515630247 365 IEPQHLHRLTERFYRVDKARsrdtGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLPNR 428
Cdd:PRK11466 604 IDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-419 |
4.54e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 62.48 E-value: 4.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 318 DEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARsRDTGGSGLGLAI 397
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90 100
....*....|....*....|..
gi 515630247 398 VKHALSHHDSHLEIQSEVGVGS 419
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGA 101
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
305-425 |
9.68e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 59.18 E-value: 9.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 305 LEFDIDKSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRwyQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKAR 384
Cdd:cd16954 21 ISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTAR--QTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQR 98
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 515630247 385 SrdtgGSGLGLAIVKHALSHHDSHLEI-QSEVGvGSRFHFTL 425
Cdd:cd16954 99 P----GQGLGLAIAKEIVEQYGGELSLsDSPLG-GARFEVVF 135
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
196-426 |
2.80e-10 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 62.45 E-value: 2.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 196 VTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEdpdmivgpmwtkaHGVMTEQ----LNRMNSLVnqlLTLSKIea 271
Cdd:TIGR03785 475 VARLRQYTHYLENMSSRLSHELRTPVAVVRSSLENLE-------------LQALEQEkqkyLERAREGT---ERLSMI-- 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 272 apMHELDEVVNVPAMLEVLEKE----AASLSG--------DREHKLEFDIDKSLRVL-ADEDQLRSAISNLVYNAVKYTP 338
Cdd:TIGR03785 537 --LNNMSEATRLEQAIQSAEVEdfdlSEVLSGcmqgyqmtYPPQRFELNIPETPLVMrGSPELIAQMLDKLVDNAREFSP 614
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 339 PGATVKVRWYQTSQGACLDVSDTGDGIePQHLH-RLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLE---IQSE 414
Cdd:TIGR03785 615 EDGLIEVGLSQNKSHALLTVSNEGPPL-PEDMGeQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQaenRQQN 693
|
250
....*....|..
gi 515630247 415 VGVgsRFHFTLP 426
Cdd:TIGR03785 694 DGV--VFRISLP 703
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
1.65e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 55.24 E-value: 1.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 318 DEDQLRSAISNLVYNA------VKYTPPGATVKVRWYQTSQGAcLDVSDTGDGIEPQHLHRLTERfYRVDKARsrdtgGS 391
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaiegRPSDVGEVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEP-YVTTRPK-----GT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 515630247 392 GLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
2.78e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 54.50 E-value: 2.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 322 LRSAISNLVYNAVKYTPPG-ATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrVDKARSRDTG-GSGLGLAIVK 399
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 515630247 400 HALSHHD--SHLEI--QSEVGVGSRFHFTLP 426
Cdd:cd16953 80 QIIEAHGgiSVAENhnQPGQVIGARFTVQLP 110
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-426 |
1.16e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 52.67 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 326 ISNLVYNAVKYT----PPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrvdkaRSRDTGGSGLGLAIVKHA 401
Cdd:cd16915 5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV-----STKGQGERGIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 515630247 402 LSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
199-426 |
2.17e-08 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 56.22 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 199 LKQLEGmrrnffaNVSHELRTPMTVLQGYLE----MTEDPDMIVGPMWTKAHGVmTEQLNRMNSLVNQLLTLSKIEaapm 274
Cdd:PRK13557 163 LGQLTG-------GIAHDFNNLLQVMSGYLDviqaALSHPDADRGRMARSVENI-RAAAERAATLTQQLLAFARKQ---- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 275 hELD-EVVNVPAMLEVLEKEAASLSGDrEHKLEFDIDKSL---RVlaDEDQLRSAISNLVYNAVKYTPPGATVKVR---- 346
Cdd:PRK13557 231 -RLEgRVLNLNGLVSGMGELAERTLGD-AVTIETDLAPDLwncRI--DPTQAEVALLNVLINARDAMPEGGRVTIRtrnv 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 347 ---------WYQTSQG--ACLDVSDTGDGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKHALSHHDSHLEIQSE 414
Cdd:PRK13557 307 eiededlamYHGLPPGryVSIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSE 381
|
250
....*....|..
gi 515630247 415 VGVGSRFHFTLP 426
Cdd:PRK13557 382 VGEGTTVRLYFP 393
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
302-428 |
6.30e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 54.64 E-value: 6.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 302 EHKLEFDIDkslrvlADEDQLRSAI-----SNLVYNAVKY----TPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHR 372
Cdd:COG2972 318 GDRLEVEIE------IDEELLDLLIpklilQPLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEK 391
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 515630247 373 LTERFyrvdkarSRDTGGSGLGLAIVKHALSHH---DSHLEIQSEVGVGSRFHFTLPNR 428
Cdd:COG2972 392 LLEEL-------SSKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRIPLE 443
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
355-426 |
9.63e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 50.07 E-value: 9.63e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515630247 355 CLDVSDTGDGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16919 49 CLEVSDTGSGMPAEVLRRAFEPFFT-----TKEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
98-196 |
1.14e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 50.11 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPD-------FIKYLNKQDFSEPLEM--P 168
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDdaevaelLRQALLQGEESRGFEVsfR 80
|
90 100 110
....*....|....*....|....*....|...
gi 515630247 169 SPLNVERMLELRIVPYTEGEH-----LMVVRDV 196
Cdd:pfam00989 81 VPDGRPRHVEVRASPVRDAGGeilgfLGVLRDI 113
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
98-203 |
4.43e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 50.79 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLN---------KQDFSEPLEMP 168
Cdd:COG2202 137 ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLEllrrlleggRESYELELRLK 216
|
90 100 110
....*....|....*....|....*....|....*....
gi 515630247 169 SPLNVERMLELRIVPYTEGEH----LMVVRDVTQLKQLE 203
Cdd:COG2202 217 DGDGRWVWVEASAVPLRDGGEvigvLGIVRDITERKRAE 255
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
254-426 |
6.03e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 51.44 E-value: 6.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 254 NRMNSL--VNQLLTLSK-IEAAPMHELdevvnvpamLEVLEKEAASLSGDREHKLEFDIDkslRVLADEDQLRS---AIS 327
Cdd:COG3920 338 NRIQALalVHELLYQSEdWEGVDLRDY---------LRELLEPLRDSYGGRGIRIELDGP---DVELPADAAVPlglILN 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 328 NLVYNAVKYTPPGA---TVKVRWYQTSQGACLDVSDTGDGIEPQhlhrlterfyrVDKARSRdtggsGLGLAIVKHALSH 404
Cdd:COG3920 406 ELVTNALKHAFLSGeggRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQ 469
|
170 180
....*....|....*....|..
gi 515630247 405 HDSHLEIQSEVGVgsRFHFTLP 426
Cdd:COG3920 470 LGGTLELDRPEGT--RVRITFP 489
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
300-426 |
2.45e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 49.53 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 300 DREHKLEFDIDKSLRVLADEDQ---LRSAISNLVYN---AVKYTPPGA-TVKVRwYQTSQGAClDVSDTGDGIEPQHLHR 372
Cdd:PRK11086 409 ELGITLIISEDSQLPDSGDEDQvheLITILGNLIENaleAVGGEEGGEiSVSLH-YRNGWLHC-EVSDDGPGIAPDEIDA 486
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 515630247 373 LTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK11086 487 IFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-425 |
2.98e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 45.53 E-value: 2.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 328 NLVYNAV----KYTPPGATVKVRWyqTSQGACLDVSDTGDGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKHAL 402
Cdd:cd16976 7 NLLQNALdamgKVENPRIRIAARR--LGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYGIV 79
|
90 100
....*....|....*....|...
gi 515630247 403 SHHDSHLEIQSEVGVGSRFHFTL 425
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFDL 102
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
183-420 |
3.15e-06 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 49.25 E-value: 3.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 183 PYTEGEHLMVVRDVTQLKQLEGMR----RNFFANVSHELRTPMTVLQGYL-EMTEDPDMIVgpmwTKAHGVMTEQLNRMN 257
Cdd:PRK10815 239 PNPPRELTSLVRNLNRLLKNERERytkyRTTLTDLTHSLKTPLAVLQSTLrSLRSGKQMSV----EQAEPIMLEQISRIS 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 258 SLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLekeAASLSGDREHK---LEFDIDKSLRVLADEDQLRSAISNLVYNAV 334
Cdd:PRK10815 315 QQIGYYLHRASMRSEHNLLSRELHSVAPLLDNL---TSALNKVYQRKgvnITLDISPEITFVGEKNDFMEVMGNVLDNAC 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 335 KYTPPGATVKVRwyQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSrdtgGSGLGLAIVKHALSHHDSHLEI-QS 413
Cdd:PRK10815 392 KYCLEFVEISAR--QTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAgDS 465
|
....*..
gi 515630247 414 EVGvGSR 420
Cdd:PRK10815 466 PLG-GAR 471
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
92-203 |
9.73e-06 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 46.94 E-value: 9.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 92 ELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLnkQDFSEPLEMPSPL 171
Cdd:COG2202 5 ALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFL--ELLRAALAGGGVW 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 515630247 172 NVE----------RMLELRIVPYT--EGE---HLMVVRDVTQLKQLE 203
Cdd:COG2202 83 RGElrnrrkdgslFWVELSISPVRdeDGEitgFVGIARDITERKRAE 129
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
306-426 |
1.09e-05 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 45.65 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 306 EFDIDKSlrVLadeDQLRSAISNLVYNAV------------KYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRl 373
Cdd:cd16916 28 DTELDKS--VL---EKLADPLTHLLRNAVdhgieapeerlaAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDREKIRE- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 374 terfyrvdKARSR--------------------------------DTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRF 421
Cdd:cd16916 102 --------KAIERglitadeaatlsddevlnlifapgfstaeqvtDVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTF 173
|
....*
gi 515630247 422 HFTLP 426
Cdd:cd16916 174 TIRLP 178
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
98-152 |
1.32e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 42.77 E-value: 1.32e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 515630247 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDF 152
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDR 55
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
92-203 |
1.54e-05 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 47.07 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 92 ELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQDfSEPLEMPSPL 171
Cdd:COG3829 5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLKTGK-PVTGVIQKTG 83
|
90 100 110
....*....|....*....|....*....|....*.
gi 515630247 172 NVERMLELRIVP-YTEGEHLMVV---RDVTQLKQLE 203
Cdd:COG3829 84 GKGKTVIVTAIPiFEDGEVIGAVetfRDITELKRLE 119
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
320-426 |
2.35e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 43.75 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 320 DQLRSAISNLVYNAVKYT---PPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLhrlterfyrvdKARSRDTGGSGLGLA 396
Cdd:COG2172 33 DDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDL-----------PDPYSTLAEGGRGLF 101
|
90 100 110
....*....|....*....|....*....|
gi 515630247 397 IVKhALSHhdsHLEIQSEVGvGSRFHFTLP 426
Cdd:COG2172 102 LIR-RLMD---EVEYESDPG-GTTVRLVKR 126
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
107-196 |
2.41e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 43.01 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 107 LPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNK--------QDFSEPLEMPSPLNVERMLE 178
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERlenllsggEPVTLEVRLRRKDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 515630247 179 LRIVPYTEG-----EHLMVVRDV 196
Cdd:cd00130 81 VSLTPIRDEggeviGLLGVVRDI 103
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
98-203 |
4.19e-05 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 43.05 E-value: 4.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIrTPDFI----KYLNKQDFSEPLEMPSPLNV 173
Cdd:TIGR00229 3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELI-PEEDReevrERIERRLEGEPEPVSEERRV 81
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 515630247 174 ------ERMLELRIVP-YTEGEH---LMVVRDVTQLKQLE 203
Cdd:TIGR00229 82 rrkdgsEIWVEVSVSPiRTNGGElgvVGIVRDITERKEAE 121
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
325-405 |
5.59e-05 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 41.48 E-value: 5.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 325 AISNLVYNAVKYT---PPGATVKVRWYQTSQGACLDVSDTGDGIEPqhlhrlterfyRVDKARSRDTGGSGLGLAIVkHA 401
Cdd:cd16936 4 AVSEAVTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGFDP-----------LRPADPDAGLREGGRGLALI-RA 71
|
....
gi 515630247 402 LSHH 405
Cdd:cd16936 72 LMDE 75
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-426 |
8.88e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 41.61 E-value: 8.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 326 ISNLVYNAVK----YTPPGATVKVRWYQTSQGAC-LDVSDTGDGIEPQHLHRLTERFYRVDKArsrdtgGSGLGLAIVKH 400
Cdd:cd16920 5 LINLVRNGIEamseGGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICRS 78
|
90 100
....*....|....*....|....*.
gi 515630247 401 ALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-426 |
1.02e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 41.28 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 329 LVYNAVKY-----TPPGA-TVKVRwyQTSQGACLDVSDTGDGIEPQHLHRLTERfyrvdkarsrDTGGSGLGLAIVKHAL 402
Cdd:cd16924 9 LVENAIQHglsplTDKGVvTISAL--KEDNHVMIEVEDNGRGIDPKVLNILGKK----------PKEGNGIGLYNVHQRL 76
|
90 100
....*....|....*....|....*..
gi 515630247 403 SH---HDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16924 77 ILlfgEDYGIHIASEPDKGTRITFTIP 103
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
105-201 |
1.37e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 41.25 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 105 ESLPDAVVVFRGEGNIVWCNKLAQYLLGFR------------WPDDSGQPISNLIRtpdfiKYLNKQDFSEPLEMPSPLN 172
Cdd:pfam08448 2 DSLPDALAVLDPDGRVRYANAAAAELFGLPpeellgktlaelLPPEDAARLERALR-----RALEGEEPIDFLEELLLNG 76
|
90 100 110
....*....|....*....|....*....|....
gi 515630247 173 VERMLELRIVPYTEGE-----HLMVVRDVTQLKQ 201
Cdd:pfam08448 77 EERHYELRLTPLRDPDgevigVLVISRDITERRR 110
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
290-426 |
1.67e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 43.07 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 290 LEKEAASLSGDREHKLEFDIDKSLRVLAD--EDQLRSAISNLVYNAVKYTPpGATVKVRWYQTSQGACLDVSDTGDGIEP 367
Cdd:COG4585 129 LEELAERLLRAAGIRVELDVDGDPDRLPPevELALYRIVQEALTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDP 207
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 515630247 368 QhlhrlterfyrvdkarsrDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG4585 208 E------------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-426 |
2.83e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 39.46 E-value: 2.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 332 NAVKYTPpGATVKVRWYQTSQGACLDVSDTGDGIEPqhlhrlterfyrvdkarSRDTGGSGLGLAIVKHALSHHDSHLEI 411
Cdd:cd16917 11 NALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDG-----------------PAPPGGGGFGLLGMRERAELLGGTLTI 72
|
90
....*....|....*
gi 515630247 412 QSEVGVGSRFHFTLP 426
Cdd:cd16917 73 GSRPGGGTRVTARLP 87
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-426 |
3.25e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 40.08 E-value: 3.25e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515630247 356 LDVSDTGDGIEPQHLHRLterFYRVDKARSrdtGGSGLGLAIVKHALSHHDSHLEIQSEVGvGSRFHFTLP 426
Cdd:cd16918 46 VSVIDNGPGIPPDLQDTI---FYPMVSGRE---NGTGLGLAIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
3.37e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 39.72 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 325 AISNLVYNAVKYT----PPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrvdkarsrdTGGSGLGLAIVK- 399
Cdd:cd16957 5 ALQVLVENAIRHAfpkrKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTV---------TSEKGTGTALENl 75
|
90 100 110
....*....|....*....|....*....|.
gi 515630247 400 ----HALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16957 76 nrrlIGLFGSEACLHIESEVHGGTEVWFVIP 106
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
106-426 |
1.43e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 41.07 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 106 SLPDAVVVFRGEGN-IVWCNKLAQYLLgfrwPDDSGQPISNL-------IRTPdfikylnkqdfseplempspLNVE--- 174
Cdd:PRK10618 351 NLPLGLLVYDFESNrTVISNKIADHLL----PHLNLQKITTMaeqhqgvIQAT--------------------INNElye 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 175 -RMLELRIVPYTegeHLMVVRD------VT---QLKQLE-----GMRRNFFANVSHELRTPMTVLQ------GYLEMTED 233
Cdd:PRK10618 407 iRMFRSQLAPRT---QLFLLRDqdrevlVNkklQQAQREyeknqQARKAFLQNIGDELKQPLQSLAqlaaqlRQTSDEEQ 483
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 234 PDMIVGPMWTKahgvmTEQLNRM--N-SLVNQLLTLS-KIEAAP--MHEL-DEVVnvPAMLEVLEKEAASLSGdrehklE 306
Cdd:PRK10618 484 QQPELDQLAEQ-----SDVLVRLvdNiQLLNMLETQDwKPEQELfsLQDLiDEVL--PEVLPAIKRKGLQLLI------H 550
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 307 FDIDKSLRVLADEDQLRSAISNLVYNAVKYTPPGA-TVKVRWYQTSQGACL-DVSDTGDGIEPQHLHRL---------TE 375
Cdd:PRK10618 551 NHLKAEQLRIGDRDALRKILLLLLNYAITTTAYGKiTLEVDQDESSPDRLTiRILDTGAGVSIKELDNLhfpflnqtqGD 630
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 515630247 376 RFYRvdkarsrdtgGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK10618 631 RYGK----------ASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
1.49e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 37.80 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 325 AISNLVYNAVKY----TPPGATVKVRWYQTSQGACLDVSDTGDGIEPqhlhrlterfyrVDKARSRDTGGSGLGLAIVKH 400
Cdd:cd16956 5 TLQPIVENAVKHglsgLLDGGRVEITARLDGQHLLLEVEDNGGGMDP------------DTLARILIRSSNGLGLNLVDK 72
|
90 100
....*....|....*....|....*....
gi 515630247 401 ALSH---HDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16956 73 RLRQafgNDYGLDIECAPGEGTRITIRLP 101
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
98-163 |
4.75e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 35.60 E-value: 4.75e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515630247 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGfrwPDDSGQPISNLIRTPDFIKYLNKQDFSE 163
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLG---YELLGELLGELLDLLDPLLEDALELLRE 63
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
317-400 |
7.28e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 36.50 E-value: 7.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630247 317 ADEDQLRSAISNLVYNAVKY---TPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTErfyrvdKARSRDTGGSGL 393
Cdd:pfam13581 27 ELLDEVELAVGEACTNAVEHayrEGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDL------EEPDEDRKEGGR 100
|
....*..
gi 515630247 394 GLAIVKH 400
Cdd:pfam13581 101 GLALIRG 107
|
|
| |
