|
Name |
Accession |
Description |
Interval |
E-value |
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
1-432 |
0e+00 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 857.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 1 MVEKLTWKKLVWELVFFYAPWVFVGWIFGYLPWLLLAATVLQLGWHLHNQMRLSAWLWDEKRLTPPSGSGNWESLFNGIY 80
Cdd:PRK11006 1 MLERLSWKRLVLELALFCLPALILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLFYGLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 81 RMQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQD 160
Cdd:PRK11006 81 QMQLRNRKRRRELGNLIKRFRSGAESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEFTQYLKTRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 161 FSEPLEMpsPLNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMiVGP 240
Cdd:PRK11006 161 FSRPLTL--VLNNGRHLEIRVMPYTEGQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPL-EGA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 241 MWTKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDCgHKLEFDIDTSLRVLADED 320
Cdd:PRK11006 238 LREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGK-HTITFEVDNSLKVFGNED 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 321 QLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKH 400
Cdd:PRK11006 317 QLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKH 396
|
410 420 430
....*....|....*....|....*....|..
gi 515623564 401 ALSHHDSHLEIQSEVGVGSRFHFTLPNRLTVS 432
Cdd:PRK11006 397 ALSHHDSRLEIESEVGKGTRFSFVLPERLIAK 428
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
93-425 |
0e+00 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 542.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 93 LTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQDFSEPLEMPSPLN 172
Cdd:TIGR02966 1 LSALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEFVEYLAAGRFSEPLELPSPIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 173 VERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMIVGPMWTKAHGVMTEQ 252
Cdd:TIGR02966 81 SERVLEIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 253 LNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDCGHKLEFDIDTSLRVLADEDQLRSAISNLVYN 332
Cdd:TIGR02966 161 SQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 333 AVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQ 412
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIE 320
|
330
....*....|...
gi 515623564 413 SEVGVGSRFHFTL 425
Cdd:TIGR02966 321 SELGKGSTFSFIF 333
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
171-426 |
3.35e-101 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 306.86 E-value: 3.35e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 171 LNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMIVGPMWTKAHGVMT 250
Cdd:COG5002 130 LLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIIL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 251 EQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDCGHKLEFDI-DTSLRVLADEDQLRSAISNL 329
Cdd:COG5002 210 EEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpEDPLLVLGDPDRLEQVLTNL 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 330 VYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHL 409
Cdd:COG5002 290 LDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRI 369
|
250
....*....|....*..
gi 515623564 410 EIQSEVGVGSRFHFTLP 426
Cdd:COG5002 370 WVESEPGKGTTFTITLP 386
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
175-426 |
3.51e-71 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 227.48 E-value: 3.51e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 175 RMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPdmiVGPMWTKAHGVMTEQLN 254
Cdd:COG0642 79 LLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE---LDEEQREYLETILRSAD 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 255 RMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDCGHKLEFDIDTSL-RVLADEDQLRSAISNLVYNA 333
Cdd:COG0642 156 RLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNA 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 334 VKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLEIQS 413
Cdd:COG0642 236 IKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVES 313
|
250
....*....|...
gi 515623564 414 EVGVGSRFHFTLP 426
Cdd:COG0642 314 EPGKGTTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
194-426 |
3.88e-70 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 221.70 E-value: 3.88e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 194 RDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMIVGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEAAP 273
Cdd:COG2205 4 EALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 274 MHELDEVVNVPAMLEVLEKEAASLSGDCGHKLEFDID-TSLRVLADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQ 352
Cdd:COG2205 84 LSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPpELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGD 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515623564 353 GACLDVSDTGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG2205 164 GVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-429 |
2.48e-55 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 178.93 E-value: 2.48e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHA 401
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*...
gi 515623564 402 LSHHDSHLEIQSEVGVGSRFHFTLPNRL 429
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
98-429 |
1.05e-52 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 183.64 E-value: 1.05e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPD---FIKYLNKQDFSEPL---EMPSPL 171
Cdd:COG5809 141 EKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDqenVAAFISQLLKDGGIaqgEVRFWT 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 172 NVERM--LELRIVPYTEGEH----LMVVRDVTQLKQLE-GMRRN--------FFANVSHELRTPMTVLQGYLEMTEDPDM 236
Cdd:COG5809 221 KDGRWrlLEASGAPIKKNGEvdgiVIIFRDITERKKLEeLLRKSeklsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTID 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 237 IVGPMWTkahGVMTEQLNRMNSLVNQLLTLSKIEAAPMHE--LDEVVNvpAMLEVLEKEAasLSGDCGHKLEFDIDTSLr 314
Cdd:COG5809 301 EEQKTYL---DIMLSELDRIESIISEFLVLAKPQAIKYEPkdLNTLIE--EVIPLLQPQA--LLKNVQIELELEDDIPD- 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 315 VLADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGAC-LDVSDTGDGIEPQHLHRLTERFYrvdkarSRDTGGSGL 393
Cdd:COG5809 373 ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVvISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGL 446
|
330 340 350
....*....|....*....|....*....|....*.
gi 515623564 394 GLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLPNRL 429
Cdd:COG5809 447 GLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKL 482
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
92-426 |
3.33e-52 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 180.54 E-value: 3.33e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 92 ELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQ-DFSEPLEMPSP 170
Cdd:COG5000 84 ELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREAlERGWQEEIELT 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 171 LNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGM-------RRnffanVSHELRTPMTVLQGYLE---------MTEDP 234
Cdd:COG5000 164 RDGRRTLLVRASPLRDDGYVIVFDDITELLRAERLaawgelaRR-----IAHEIKNPLTPIQLSAErlrrkladkLEEDR 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 235 DMIvgpmwTKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMheldEVVNVPAMLEvlekEAASL----SGDCGHKLEFDID 310
Cdd:COG5000 239 EDL-----ERALDTIIRQVDRLKRIVDEFLDFARLPEPQL----EPVDLNELLR----EVLALyepaLKEKDIRLELDLD 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 311 -TSLRVLADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrvdkarSRDTG 389
Cdd:COG5000 306 pDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPK 379
|
330 340 350
....*....|....*....|....*....|....*..
gi 515623564 390 GSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG5000 380 GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
92-426 |
1.52e-51 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 177.35 E-value: 1.52e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 92 ELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPD-FIKYL-----NKQDFSEP- 164
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSpLRELLeralaEGQPVTERe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 165 LEMPSPLNVERMLELRIVPYTEGEH----LMVVRDVTQLKQLEG-MRRN--------FFANVSHELRTPMTVLQGYLEM- 230
Cdd:COG3852 81 VTLRRKDGEERPVDVSVSPLRDAEGeggvLLVLRDITERKRLEReLRRAeklaavgeLAAGLAHEIRNPLTGIRGAAQLl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 231 ------TEDPDMIvgpmwtkahGVMTEQLNRMNSLVNQLLTLSKIEAAPMheldEVVNVPAMLE----VLEKEAASlsgd 300
Cdd:COG3852 161 erelpdDELREYT---------QLIIEEADRLNNLVDRLLSFSRPRPPER----EPVNLHEVLErvleLLRAEAPK---- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 301 cGHKLEFDIDTSL-RVLADEDQLRSAISNLVYNAVKYTPPGATVRVR----------WYQTSQGACLDVSDTGDGIEPQH 369
Cdd:COG3852 224 -NIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRtrverqvtlgGLRPRLYVRIEVIDNGPGIPEEI 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 515623564 370 LHRLTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG3852 303 LDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
118-426 |
5.93e-51 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 181.10 E-value: 5.93e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 118 GNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDfikylnKQDFSEPLEMPSPLNVERMlelrivpyTEGEHLM------ 191
Cdd:NF033092 278 GRVILINDPALEMLNVSRETVLGQSILDVLGLEE------EYTLRDLLEEQDSLLLDFS--------TEEEPLIlranfs 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 192 --------------VVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMT-----EDPDmiVGPmwtKAHGVMTEQ 252
Cdd:NF033092 344 viqresgfingliaVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALadgawKDPE--LAP---RFLGVTQNE 418
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 253 LNRMNSLVNQLLTLSKIEAAPMhELD-EVVNVPAMLE--------VLEKEAASLsgdcghKLEFDiDTSLRVLADEDQLR 323
Cdd:NF033092 419 TERMIRLVNDLLQLSRMDSKDY-KLNkEWVNFNEFFNyiidrfemILKNKNITF------KREFP-KRDLWVEIDTDKIT 490
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 324 SAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALS 403
Cdd:NF033092 491 QVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVE 570
|
330 340
....*....|....*....|...
gi 515623564 404 HHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:NF033092 571 AHGGRIWAESEEGKGTTIYFTLP 593
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
105-426 |
1.33e-40 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 152.81 E-value: 1.33e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 105 ESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNL-IRTPDFIKYL------NKQDFSEPLEMPSPlnvERML 177
Cdd:PRK11360 269 ESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELfPPNTPFASPLldtlehGTEHVDLEISFPGR---DRTI 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 178 EL----RIVPYTEGE---HLMVVRDVTQLKQL-EGMRR--------NFFANVSHELRTPMTVLQGYLEMTEDPDMivGPM 241
Cdd:PRK11360 346 ELsvstSLLHNTHGEmigALVIFSDLTERKRLqRRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTS--DPP 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 242 WTKAHGVMTEQLNRMNSLVNQLLTLSKieaaPMHEldevVNVPAMLEVLEKEAASLSGDCGHKLEFDIDTSLR-----VL 316
Cdd:PRK11360 424 SQEYLSVVLREVDRLNKVIDQLLEFSR----PRES----QWQPVSLNALVEEVLQLFQTAGVQARVDFETELDnelppIW 495
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 317 ADEDQLRSAISNLVYNAVKYTPPGATVRVR-WYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVdKARsrdtgGSGLGL 395
Cdd:PRK11360 496 ADPELLKQVLLNILINAVQAISARGKIRIRtWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTT-KAK-----GTGLGL 569
|
330 340 350
....*....|....*....|....*....|.
gi 515623564 396 AIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK11360 570 ALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
199-426 |
8.36e-40 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 148.30 E-value: 8.36e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 199 LKQLE-GMRR--NFFANVSHELRTPMTVL--QGYLEMTEDPDmivGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIE--- 270
Cdd:TIGR01386 231 LGRLEdAFQRlsQFSADLAHELRTPLTNLlgQTQVALSQPRT---GEEYREVLESNLEELERLSRMVSDMLFLARADngq 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 271 -AAPMHELD---EVVNVPAMLEVLEKEAAslsgdcghkLEFDIDTSLRVLADEDQLRSAISNLVYNAVKYTPPGATVRVR 346
Cdd:TIGR01386 308 lALERVRLDlaaELAKVAEYFEPLAEERG---------VRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVR 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 347 WYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGvGSRFHFTLP 426
Cdd:TIGR01386 379 IERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG-KTRFILRFP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
210-426 |
5.07e-37 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 141.46 E-value: 5.07e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 210 FAN-VSHELRTPMTVLQGYLEMTE-------DPDmivgpmwTKAH-GVMTEQLNRMNSLVNQLLTLSKIEAAPMHEldEV 280
Cdd:COG4251 285 FAYvASHDLREPLRKISGFSQLLEedygdklDEE-------GREYlERIRDAAERMQALIDDLLAYSRVGRQELEF--EP 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 281 VNVPAML-EVLEKEAASLSGdcgHKLEFDIDTSLRVLADEDQLRSAISNLVYNAVKYTPPG--ATVRVRWYQTSQGACLD 357
Cdd:COG4251 356 VDLNELLeEVLEDLEPRIEE---RGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFS 432
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515623564 358 VSDTGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG4251 433 VRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
180-426 |
1.81e-36 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 139.19 E-value: 1.81e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 180 RIVPYTEGEHLMVVRDVTQLKQL----EGMRRNFFANVSHELRTPMTVLQGYLEMTED------PDMIVGpmwtkahgvM 249
Cdd:NF012163 210 RVTPTSNDELGKLAQDFNQLASTleknEQMRRDFMADISHELRTPLAVLRAELEAIQDgirkftPESLDS---------L 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 250 TEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDCGHKLEFDIDTSLRVLADEDQLRSAISNL 329
Cdd:NF012163 281 QAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNL 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 330 VYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI-VKHALSHHDSH 408
Cdd:NF012163 361 LENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAIsLNIVQAHGGTL 440
|
250
....*....|....*...
gi 515623564 409 LEIQSEVGvGSRFHFTLP 426
Cdd:NF012163 441 HAAHSPLG-GLRIVVTLP 457
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
105-426 |
5.34e-36 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 138.33 E-value: 5.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 105 ESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPD--FIKYLNKQDFSEPLEMPSPLNV------ERM 176
Cdd:COG5805 164 ENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDkeEFKERIESITEVWQEFIIEREIitkdgrIRY 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 177 LELRIVPY--TEGEH---LMVVRDVTQLKQLEGMRRNF---------FANVSHELRTPMTVLQGYLEMtedpdMIVGPMW 242
Cdd:COG5805 244 FEAVIVPLidTDGSVkgiLVILRDITEKKEAEELMARSeklsiagqlAAGIAHEIRNPLTSIKGFLQL-----LQPGIED 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 243 TKAHG-VMTEQLNRMNSLVNQLLTLSKieaaPMHELDEVVNVPAMLE----VLEKEAaSLSGDcghKLEFD-IDTSLRVL 316
Cdd:COG5805 319 KEEYFdIMLSELDRIESIISEFLALAK----PQAVNKEKENINELIQdvvtLLETEA-ILHNI---QIRLElLDEDPFIY 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 317 ADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrvdkarSRDTGGSGLGLA 396
Cdd:COG5805 391 CDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLM 464
|
330 340 350
....*....|....*....|....*....|
gi 515623564 397 IVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG5805 465 VSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
317-426 |
1.85e-35 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 126.61 E-value: 1.85e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 317 ADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKaRSRDTGGSGLGLA 396
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|
gi 515623564 397 IVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
211-426 |
5.28e-33 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 127.61 E-value: 5.28e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 211 ANVSHELRTPMTVLQGYLEMTED--PDMIVGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELD--EVVNvpAM 286
Cdd:COG4191 147 AGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDlnELID--EA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 287 LEVLEKEAaslsGDCGHKLEFDIDTSL-RVLADEDQLRSAISNLVYNAVKYTPPGA--TVRVRWYQTSQGACLDVSDTGD 363
Cdd:COG4191 225 LELLRPRL----KARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRREGDYVVISVRDNGP 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515623564 364 GIEPQHLHRLTERFY---RVDKarsrdtgGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG4191 301 GIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
208-428 |
3.78e-32 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 127.20 E-value: 3.78e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 208 NFFANVSHELRTPMTVLQGYLEMT--------EDPDMIVGPMwtkahgvmtEQLNRMNSLVNQLLTLSK-------IEAA 272
Cdd:PRK09835 264 NFSADIAHEIRTPITNLITQTEIAlsqsrsqkELEDVLYSNL---------EELTRMAKMVSDMLFLAQadnnqliPEKK 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 273 PMHELDEVVNVPAMLEVLEKEAASlsgdcghKLEFDiDTSLRVLADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQ 352
Cdd:PRK09835 335 MLDLADEVGKVFDFFEAWAEERGV-------ELRFV-GDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDH 406
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515623564 353 GACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVgVGSRFHFTLPNR 428
Cdd:PRK09835 407 QVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLPRL 481
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
194-428 |
1.02e-31 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 126.29 E-value: 1.02e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 194 RDVTQLKQLEGMRRNFFANVSHELRTPMTVLQgyleMTED------PDMivGPMWTKAHGVMTEQLNRMNSLVNQLLTLS 267
Cdd:NF040691 259 RQIRQLEELSRLQQRFVSDVSHELRTPLTTIR----MAADvihdsrDDF--DPATARSAELLHTELDRFESLLSDLLEIS 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 268 KIEA-APMHELDEVVNVPAMLEVLEkEAASLSGDCGHKLEFDI-DTSLRVLADEDQLRSAISNLVYNAVKYTpPGATVRV 345
Cdd:NF040691 333 RFDAgAAELDVEPVDLRPLVRRVVD-ALRQLAERAGVELRVDApGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVV 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 346 RWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTL 425
Cdd:NF040691 411 TVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTL 490
|
...
gi 515623564 426 PNR 428
Cdd:NF040691 491 PRV 493
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
8.47e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 111.79 E-value: 8.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 318 DEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI 397
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 515623564 398 V-KHALSHHDSHLEIQSEVGvGSRFHFTLP 426
Cdd:cd16946 81 ChNIALAHGGTISAEHSPLG-GLRLVLTLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
317-426 |
3.85e-29 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 109.77 E-value: 3.85e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 317 ADEDQLRSAISNLVYNAVKYTPPGATVRVRwYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKarsRDTGGSGLGLA 396
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 515623564 397 IVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
199-426 |
3.92e-29 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 118.58 E-value: 3.92e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 199 LKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDpdmivgpmwtkahGVMTEQLNRMNSLVNQLLTLSKIeAAPMHEL- 277
Cdd:PRK10549 233 LEKNEQMRRDFMADISHELRTPLAVLRGELEAIQD-------------GVRKFTPESVASLQAEVGTLTKL-VDDLHQLs 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 278 --DE--------VVNVPAMLEVlekEAASLSGDCGHK---LEFDIDTSLRVLADEDQLRSAISNLVYNAVKYTPPGATVR 344
Cdd:PRK10549 299 lsDEgalayrktPVDLVPLLEV---AGGAFRERFASRgltLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLH 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 345 VRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQ-SEVGvGSRFHF 423
Cdd:PRK10549 376 ISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITV 454
|
...
gi 515623564 424 TLP 426
Cdd:PRK10549 455 ELP 457
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
322-426 |
4.13e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 107.19 E-value: 4.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAVKYTPPGA-TVRVRWYQTSQGA---CLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI 397
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 515623564 398 VKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
15-426 |
6.98e-27 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 111.09 E-value: 6.98e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 15 VFFYAPWVFVGWIFGYLPWLLLAATVLQLGWHLHNQMRLSAWLWDEKRLTPPSGSGNWESLFNGIYRMQQRQRRKRKELT 94
Cdd:COG3290 1 LLLLLLLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 95 NLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFrwpDDSGQPISNLIRtpdfiKYLNKQDFSEPLEMPsplnvE 174
Cdd:COG3290 81 RLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLA-----EVLETGERDEEILLN-----G 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 175 RMLELRIVPYTEGEHLM----VVRDVTQLK----QLEGMRRnfFANV----SHELRTPMTVLQGYLEMtEDPDmivgpmw 242
Cdd:COG3290 148 RVLVVNRVPIRDDGRVVgavaTFRDRTELErleeELEGVKE--LAEAlraqRHDFRNHLHTISGLLQL-GEYD------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 243 tKAHGVMTEQLNRMNSLVNQLLTLSKieaapmhelDEVVNvpAMLEVLEKEAASLsgdcGHKLEFDIDTSLRVLA-DEDQ 321
Cdd:COG3290 218 -EALEYIDEISEELQELIDSLLSRIG---------NPVLA--ALLLGKAARARER----GIDLTIDIDSDLPDLPlSDTD 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAV----KYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRvdkarSRDTGGSGLGLAI 397
Cdd:COG3290 282 LVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRGLGLAL 356
|
410 420
....*....|....*....|....*....
gi 515623564 398 VKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG3290 357 VKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
202-428 |
1.32e-26 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 111.47 E-value: 1.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 202 LEGMRR---------NFFANVSHELRTPMTVLQGYLE-MTEDPdmivgPMWTKAH--GVMTEQLNRMNSLVNQLLTLSKI 269
Cdd:PRK11100 243 LESMRVklegkayveQYVQTLTHELKSPLAAIRGAAElLQEDP-----PPEDRARftGNILTQSARLQQLIDRLLELARL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 270 EAapMHELDEV--VNVPAML-EVLEKEAASLSGdcgHKLEFDIDTS-LRVLADEDQLRSAISNLVYNAVKYTPPGATVRV 345
Cdd:PRK11100 318 EQ--RQELEVLepVALAALLeELVEAREAQAAA---KGITLRLRPDdARVLGDPFLLRQALGNLLDNAIDFSPEGGTITL 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 346 RWYQTSQGACLDVSDTGDGIEPQHLHRLTERFY---RVDKARSrdtgGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFH 422
Cdd:PRK11100 393 SAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLAT 468
|
....*.
gi 515623564 423 FTLPNR 428
Cdd:PRK11100 469 LTLPRH 474
|
|
| PhoR |
pfam11808 |
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members ... |
7-83 |
3.36e-26 |
|
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members include PhoR. A member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR is the bifunctional histidine autokinase/phospho-PhoB phosphatase that donates a phosphoryl group to PhoB when environmental Pi is limiting and removes the phosphoryl group from phosphorylated PhoB (PhoB-P) when environmental Pi is abundant.
Pssm-ID: 432090 Cd Length: 84 Bit Score: 101.14 E-value: 3.36e-26
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515623564 7 WKKLVWELVFFYAPWVFVGWIFGYLPWLLLAATVLQLGWHLHNQMRLSAWLWDEKRLTPPSGSGNWESLFNGIYRMQ 83
Cdd:pfam11808 1 WRRLLWRLALLLLPALLLGLLFGHLAAALLLALLAYLAWHLYQLLRLSRWLWRPRKLTPPDGSGLWGEIFYGLYRLQ 77
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
212-430 |
6.03e-24 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 103.14 E-value: 6.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 212 NVSHELRTPMTVLQGYLEMTEDPDMivgpmwtkahgvmTEQ--LNR----MNSLVNQLLTLSKIEAaPMHELD-EVVNVP 284
Cdd:PRK10604 218 GIAHELRTPLVRLRYRLEMSDNLSA-------------AESqaLNRdigqLEALIEELLTYARLDR-PQNELHlSEPDLP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 285 AMLEVLEKEAASLSgdcgHKLEFDIDTSLRVL---ADEDQLRSAISNLVYNAVKYTppGATVRVRWYQTSQGACLDVSDT 361
Cdd:PRK10604 284 AWLSTHLADIQAVT----PEKTVRLDTPHQGDygaLDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDD 357
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 362 GDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEI-QSEVGvGSRFHFTLPNRLT 430
Cdd:PRK10604 358 GPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCdESELG-GARFSFSWPVWHN 426
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
211-426 |
9.24e-24 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 102.25 E-value: 9.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 211 ANVSHELRTPMTVLQGYLEMTEDPDmivgPMWTKA---HGVMTEQLNRMNSLVNQLLTLSKieaaPMHELDEVVNVPAML 287
Cdd:COG5806 206 ASIAHEVRNPLTVVRGFIQLLQEPE----LSDEKRkqyIRIALEELDRAEAIITDYLTFAK----PQPEKLEKIDVSEEL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 288 EVLEKEAASLSGDCGHKLEFDIDTSLRVLADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEP 367
Cdd:COG5806 278 EHVIDVLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTK 357
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 515623564 368 QHLHRLTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG5806 358 EQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
1.69e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 91.62 E-value: 1.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAVKYTPpgATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHA 401
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 515623564 402 LSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
178-426 |
3.89e-22 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 99.24 E-value: 3.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 178 ELRIVPY--TEGEHLMVV---RDVTQLKQ----LEGMRRN---FFANVSHELRTPMTVLQGYLEMTEDPDMivgpmwtka 245
Cdd:PRK11091 243 ELRKVPFydRVGKRHGLMgfgRDITERKRyqdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLDTEL--------- 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 246 hgvMTEQLNRMNS----------LVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDCGHKLEFDIDTSL-- 313
Cdd:PRK11091 314 ---TAEQRKYLKTihvsaitlgnIFNDIIDMDKMERRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPLph 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 314 RVLADEDQLRSAISNLVYNAVKYTPPGA-TVRVrWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRV-DKARSRDTGGS 391
Cdd:PRK11091 391 KVITDGTRLRQILWNLISNAVKFTQQGGvTVRV-RYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGT 469
|
250 260 270
....*....|....*....|....*....|....*
gi 515623564 392 GLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK11091 470 GIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
312-420 |
6.98e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 90.16 E-value: 6.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 312 SLRVLADEDQLRSAISNLVYNAVKYTPPGATVRVRwYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKarsRDTGGS 391
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGS 79
|
90 100
....*....|....*....|....*....
gi 515623564 392 GLGLAIVKHALSHHDSHLEIQSEVGVGSR 420
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNAQGGGLE 108
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
189-410 |
8.57e-22 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 97.03 E-value: 8.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 189 HLMVVRDvtqlkqlegmrRNFFANVSHELRTPMTVLQGYLEMTE----DPDMivgpmWTKAHGVMTEQLNRMNSLVNQLL 264
Cdd:PRK10337 231 HAMMVRE-----------RRFTSDAAHELRSPLAALKVQTEVAQlsddDPQA-----RKKALLQLHAGIDRATRLVDQLL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 265 TLSKIEAapMHELDEVVNVPaMLEVLEKEAASLSGdcgHKLEFDIDTSLRvLADEDQLRSA--------ISNLVYNAVKY 336
Cdd:PRK10337 295 TLSRLDS--LDNLQDVAEIP-LEDLLQSAVMDIYH---TAQQAGIDVRLT-LNAHPVIRTGqplllsllVRNLLDNAIRY 367
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515623564 337 TPPGATVRVrwyqTSQGACLDVSDTGDGIEPQHLHRLTERFYRvdkARSRDTGGSGLGLAIVKHALSHHDSHLE 410
Cdd:PRK10337 368 SPQGSVVDV----TLNARNFTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVS 434
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
207-412 |
1.37e-21 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 95.42 E-value: 1.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 207 RNFFANVSHELRTPMTVLQGYLEMTEdpdmivgpmwtKAHGV----MTEQLNRMNSLVNQLLTLSKIEAA-------PMH 275
Cdd:PRK10755 138 RLFTADVAHELRTPLAGIRLHLELLE-----------KQHHIdvapLIARLDQMMHTVEQLLQLARAGQSfssghyqTVK 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 276 ELDEVVnVPAMLEVLEKEAASlsgdcGHKLEF-DIDTSLRVLADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGA 354
Cdd:PRK10755 207 LLEDVI-LPSQDELSEMLEQR-----QQTLLLpESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGA 280
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 515623564 355 CLDVSDTGDGIEPQHLHRLTERFYRVDkarSRdTGGSGLGLAIVKHALSHHDSHLEIQ 412
Cdd:PRK10755 281 VLAVEDEGPGIDESKCGELSKAFVRMD---SR-YGGIGLGLSIVSRITQLHHGQFFLQ 334
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
209-426 |
5.00e-21 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 96.00 E-value: 5.00e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 209 FFANVSHELRTPMTVLQGYLEMTEDPdmivgpmwtkahGVMTEQ---LNRMN-------SLVNQLLTLSKIEAAPMHELD 278
Cdd:TIGR02956 467 FLATMSHEIRTPLNGILGTLELLGDT------------GLTSQQqqyLQVINrsgesllDILNDILDYSKIEAGHLSISP 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 279 EVVNVPAMLEVLEKEAASLSGDCGHKLEFDIDTSLR--VLADEDQLRSAISNLVYNAVKYTPPGA-TVRVRWYQTSQGAc 355
Cdd:TIGR02956 535 RPFDLNALLDDVHHLMVSRAQLKGIQLRLNIPEQLPnwWQGDGPRIRQVLINLVGNAIKFTDRGSvVLRVSLNDDSSLL- 613
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515623564 356 LDVSDTGDGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:TIGR02956 614 FEVEDTGCGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
211-426 |
7.43e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 95.48 E-value: 7.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 211 ANVSHELRTPMTVLQGYLEMTEDpdmivGPMWTKAHGVMTEQLNRMNSL---VNQLLTLSKIEAAPMH-ELDEVVNVP-- 284
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQN-----TPLTAEQMDLADTARQCTLSLlaiINNLLDFSRIESGQMTlSLEETALLPll 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 285 --AML----EVLEKeaaSLSGDC----GHKLEFDIDTsLRvladedqLRSAISNLVYNAVKYTPPGAtVRVRWYQTSQGA 354
Cdd:PRK15347 478 dqAMLtiqgPAQSK---SLTLRTfvgaHVPLYLHLDS-LR-------LRQILVNLLGNAVKFTETGG-IRLRVKRHEQQL 545
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515623564 355 CLDVSDTGDGIEPQHLHRLTERFYRVDKarsrDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK15347 546 CFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
211-426 |
1.77e-20 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 92.32 E-value: 1.77e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 211 ANVSHELRTPMT----VLQGYLEMTEDPDMIVGP-MWTKAHGVMTEQLNRMNSLVNQLLTLSKI--EAAPMHElDEVVNV 283
Cdd:PRK09303 156 AMLAHDLRTPLTaaslALETLELGQIDEDTELKPaLIEQLQDQARRQLEEIERLITDLLEVGRTrwEALRFNP-QKLDLG 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 284 PAMLEVLEK-----EAASLsgdcghKLEFDIDTSL-RVLADEDQLRSAISNLVYNAVKYTPPGATVRVR-WYQTSQGACL 356
Cdd:PRK09303 235 SLCQEVILElekrwLAKSL------EIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSmLHRTTQKVQV 308
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 357 DVSDTGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK09303 309 SICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
193-427 |
1.86e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 93.05 E-value: 1.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 193 VRDVTQ--------LKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDmivgpmwtkahGVMTEQLNR----MNSLV 260
Cdd:PRK09467 208 VRSVTRafnqmaagIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMSEED-----------GYLAESINKdieeCNAII 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 261 NQLLT-LSKIEAAPMHELDevvnvpamLEVLEKEAASLSGDCGHKLEFDI-DTSLRVLADEDQLRSAISNLVYNAVKYTp 338
Cdd:PRK09467 277 EQFIDyLRTGQEMPMEMAD--------LNALLGEVIAAESGYEREIETALqPGPIEVPMNPIAIKRALANLVVNAARYG- 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 339 pGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALSHHDSHLEIQ--SEVG 416
Cdd:PRK09467 348 -NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELGnsEEGG 424
|
250
....*....|.
gi 515623564 417 VGSRFHFTLPN 427
Cdd:PRK09467 425 LSARAWLPLTT 435
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
211-426 |
1.07e-19 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 89.67 E-value: 1.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 211 ANVSHELRTPMTVLQGYLEMTEDpdmivgpmwtkahGVMTEQLNRMNSLVNQ----------LLTLSKIEAAPMHELDEV 280
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILD-------------GVFEPDPALFKSLLNQveglshlvedLRTLSLVENQQLRLNYES 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 281 VNvpaMLEVLEK---------EAASLsgdcghKLEFDIDTSLrVLADEDQLRSAISNLVYNAVKYTPPGaTVRVRWYQTS 351
Cdd:NF012226 210 VD---LKDSIEKvlkmfedrlEQAQL------TIVLNLTATP-VFCDRRRIEQVLIALIDNAIRYANAG-KLKISSSVIQ 278
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515623564 352 QGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGvGSRFHFTLP 426
Cdd:NF012226 279 DDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQG-NSVFTIKLP 352
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
203-426 |
1.42e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 91.64 E-value: 1.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 203 EGMRRNFFANVSHELRTPMTVLQGYLEM-TEDPDMIVGPMWTKAHGVMTEQLNrMNSLVNQLLTLSKIEAAPMH------ 275
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEIlTLDLASEGSPHARQASEIRQQVLN-TTRLVNNLLDMARIQSGGFNlrkewl 739
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 276 ELDEVVNvpAMLEVLEkeaASLSGdcgHKLEFDIDTSLRVL-ADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGA 354
Cdd:PRK10490 740 TLEEVVG--SALQMLE---PGLSG---HPINLSLPEPLTLIhVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERL 811
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515623564 355 CLDVSDTGDGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK10490 812 QLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
2.88e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 82.37 E-value: 2.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAVKYTPPGAT--VRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDkarSRDT-GGSGLGLAIV 398
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEyEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 515623564 399 KHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
3.86e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 82.05 E-value: 3.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKarSRDTGGSGLGLAIVKHA 401
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 515623564 402 LSHHDSHLEIQSEvGVGSRFHFTLP 426
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
213-405 |
4.44e-19 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 88.84 E-value: 4.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 213 VSHELRTPMTVLQgylemtedpdMIVGPMwTKAHGVMTE------QLNRMNSLVNQLLTLSKI--------EAAPMHEL- 277
Cdd:PRK09470 250 ISHELRTPLTRLQ----------LATALL-RRRQGESKElerietEAQRLDSMINDLLVLSRNqqknhlerETFKANSLw 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 278 DEVvnvpamLEVLEKEAASLsgdcGHKLEFDIDTSLRVL-ADEDQLRSAISNLVYNAVKYTppGATVRVRWYQTSQGACL 356
Cdd:PRK09470 319 SEV------LEDAKFEAEQM----GKSLTVSAPPGPWPInGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTI 386
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 515623564 357 DVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHH 405
Cdd:PRK09470 387 TVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQH 435
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
318-426 |
1.84e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 80.61 E-value: 1.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 318 DEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACL-DVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLA 396
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLlTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 515623564 397 IVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
7.50e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 78.64 E-value: 7.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAVKYTppGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKArsRDTGGSGLGLAIVKHA 401
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNA--RGTSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 515623564 402 LSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
211-426 |
1.03e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 84.84 E-value: 1.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 211 ANVSHELRTPMTVLQGYLEMTEDPdmivGPMWTKAHG---VMTEQLNRMNSLVNQLLTLSKieaaPMHELDEVVNVPAml 287
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAER----APAGGEAHQlaqVMAKEADRLNRVVSELLELVK----PTHLALQAVDLND-- 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 288 eVLEKEAASLSGDC---GHKLEFDIDTSL-RVLADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGD 363
Cdd:PRK10364 312 -LINHSLQLVSQDAnsrEIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGK 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515623564 364 GIEPQHLHRLTERFYrVDKARsrdtgGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK10364 391 GIAADQLEAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
205-271 |
1.77e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 76.10 E-value: 1.77e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515623564 205 MRRNFFANVSHELRTPMTVLQGYLEMTEDPDmiVGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEA 271
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEK--LDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
1.09e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 75.16 E-value: 1.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 325 AISNLVYNAVKYtppgATVRVRWYQTSQG--ACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHAL 402
Cdd:cd16939 4 ALDNLLRNALRY----AHRTVRIALLVSGgrLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....*
gi 515623564 403 SHHDSHLEI-QSEVGvGSRFHFTLP 426
Cdd:cd16939 80 LWHGGHVECdDSELG-GACFRLTWP 103
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
205-271 |
3.48e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 72.60 E-value: 3.48e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515623564 205 MRRNFFANVSHELRTPMTVLQGYLEMTEDPDMivGPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEA 271
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTEL--SEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
209-426 |
3.56e-16 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 81.17 E-value: 3.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 209 FFANVSHELRTPMTVLQGYLEM------TEDPDMIVGPMwtkahgvmteqlNRMNSL----VNQLLTLSKIEA------- 271
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLlqtkelPKGVDRLVTAM------------NNSSSLllkiISDILDFSKIESeqlkiep 517
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 272 ---APMheldEVVN--VPAMLEVLEKEAASLSgdCghkleF-DIDTSLRVLADEDQLRSAISNLVYNAVKYTPPGA---T 342
Cdd:PRK10841 518 refSPR----EVINhiTANYLPLVVKKRLGLY--C-----FiEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTGCivlH 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 343 VRVRWYQTsqgaCLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFH 422
Cdd:PRK10841 587 VRVDGDYL----SFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFT 662
|
....
gi 515623564 423 FTLP 426
Cdd:PRK10841 663 IRIP 666
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
213-426 |
6.15e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 80.11 E-value: 6.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 213 VSHELRTPMTVLQGYLEMTEDPdmivgpmwTKAHGVMTEQL-------NRMNSLVNQLLTLSKIEAAPMH--ELDEVVNV 283
Cdd:PRK13837 457 IAHNFNNILGAILGYAEMALNK--------LARHSRAARYIdeiisagARARLIIDQILAFGRKGERNTKpfDLSELVTE 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 284 PAMLEvlekeAASLSGdcGHKLEFDIDTS-LRVLADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQT--------SQG- 353
Cdd:PRK13837 529 IAPLL-----RVSLPP--GVELDFDQDQEpAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAklrapkvlSHGv 601
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515623564 354 ------ACLDVSDTGDGIEPQHLHRLTERFYrvdKARSrdtGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK13837 602 lppgryVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-412 |
9.01e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 72.88 E-value: 9.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTgGSGLGLAIVKHA 401
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEV 83
|
90
....*....|.
gi 515623564 402 LSHHDSHLEIQ 412
Cdd:cd16945 84 AQLHGGRITLR 94
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
5.65e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 70.78 E-value: 5.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 318 DEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARsRDTGGSGLGLAI 397
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 515623564 398 VKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
205-268 |
2.17e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 67.62 E-value: 2.17e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515623564 205 MRRNFFANVSHELRTPMTVLQGYLEMTEDpDMIVGPMWTKAHGVMTEQLNRMNSLVNQLLTLSK 268
Cdd:cd00082 3 AKGEFLANVSHELRTPLTAIRGALELLEE-ELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
185-426 |
3.90e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 74.77 E-value: 3.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 185 TEGEHLMVVRDVTQLKQLEGM--RRNFFANVSHELRTPMTVLQGYLEMtedpdmIVGPMWTKAHGVMTEQL-----NRMN 257
Cdd:PRK09959 689 TETRDLIHALEVERNKAINATvaKSQFLATMSHEIRTPISSIMGFLEL------LSGSGLSKEQRVEAISLayatgQSLL 762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 258 SLVNQLLTLSKIEAAPMHELDEVVNVPAMLE--------VLEKEAASLSgdCGHKLEfdiDTSLrVLADEDQLRSAISNL 329
Cdd:PRK09959 763 GLIGEILDVDKIESGNYQLQPQWVDIPTLVQntchsfgaIAASKSIALS--CSSTFP---DHYL-VKIDPQAFKQVLSNL 836
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 330 VYNAVKYTPPGA----TVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDtgGSGLGLAIVKHALSHH 405
Cdd:PRK09959 837 LSNALKFTTEGAvkitTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNM 914
|
250 260
....*....|....*....|.
gi 515623564 406 DSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK09959 915 QGDLSLESHPGIGTTFTITIP 935
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
105-413 |
4.94e-14 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 72.81 E-value: 4.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 105 ESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDfikyLNKQDFSEPLEMPSPL----------NVE 174
Cdd:PRK11073 14 NSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFS----LNIELMRESLQAGQGFtdnevtlvidGRS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 175 RMLELRIVPYTEGEHLMVVRDVTQLKQL---------EGMRRNFFANVSHELRTPMTVLQGYLEMTED--PDmivgPMWT 243
Cdd:PRK11073 90 HILSLTAQRLPEGMILLEMAPMDNQRRLsqeqlqhaqQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKalPD----PALT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 244 KAHGVMTEQLNRMNSLVNQLLtlskieaAPMHELDEVVNvpAMLEVLEKEAASLSGDCGH--KLEFDIDTSLRVLA-DED 320
Cdd:PRK11073 166 EYTKVIIEQADRLRNLVDRLL-------GPQRPGTHVTE--SIHKVAERVVQLVSLELPDnvRLIRDYDPSLPELAhDPD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 321 QLRSAISNLVYNAVK-YTPPGATVRVRW---YQ-TSQG------ACLDVSDTGDGIEPQHLHRLterFYRVDKARSrdtG 389
Cdd:PRK11073 237 QIEQVLLNIVRNALQaLGPEGGTITLRTrtaFQlTLHGeryrlaARIDIEDNGPGIPPHLQDTL---FYPMVSGRE---G 310
|
330 340
....*....|....*....|....
gi 515623564 390 GSGLGLAIVKHALSHHDSHLEIQS 413
Cdd:PRK11073 311 GTGLGLSIARNLIDQHSGKIEFTS 334
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
321-426 |
8.28e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 67.06 E-value: 8.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 321 QLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSrdtgGSGLGLAIVKH 400
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 515623564 401 ALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
209-430 |
2.11e-13 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 72.19 E-value: 2.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 209 FFANVSHELRTPMTVLQGYLEMTedpdmivgpMWTKAHGVMTEQLNRM----NSL---VNQLLTLSKIEAAPM------- 274
Cdd:PRK11107 296 FLANMSHELRTPLNGVIGFTRQT---------LKTPLTPTQRDYLQTIersaNNLlaiINDILDFSKLEAGKLvlenipf 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 275 --HE-LDEVVNvpaMLevlekeaASLSGDCGHKLEFDIDTSL--RVLADEDQLRSAISNLVYNAVKYTPPGAtVRVRWYQ 349
Cdd:PRK11107 367 slREtLDEVVT---LL-------AHSAHEKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESGN-IDILVEL 435
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 350 TSQGA------ClDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHF 423
Cdd:PRK11107 436 RALSNtkvqleV-QIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWF 514
|
....*..
gi 515623564 424 TLPNRLT 430
Cdd:PRK11107 515 HLPLDLN 521
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
304-425 |
6.30e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 65.23 E-value: 6.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 304 KLEFDI-DTSLRVLADEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDK 382
Cdd:cd16947 2 QVEINIpDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLED 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 515623564 383 ARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTL 425
Cdd:cd16947 82 SRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
209-428 |
2.17e-12 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 69.16 E-value: 2.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 209 FFANVSHELRTPMTVLQGYLEMTEDPDMIvgPMWTKAHGVMTEQLNRMNSLVNQLLTLSKIEA------------APMHE 276
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLADNPAL--NAQRDDLRAITDSGESLLTILNDILDYSAIEAggknvsvsdepfEPRPL 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 277 LDevvnvpAMLEVLEKEAASLSGDCGHKLEFDIDTSLRvlADEDQLRSAISNLVYNAVKYTPPGaTVRVRWYQTSQGACL 356
Cdd:PRK11466 525 LE------STLQLMSGRVKGRPIRLATDIADDLPTALM--GDPRRIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLV 595
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515623564 357 DVSDTGDGIEPQHLHRLTERFYRVDKARsrdtGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLPNR 428
Cdd:PRK11466 596 EVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-419 |
5.51e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 62.09 E-value: 5.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 318 DEDQLRSAISNLVYNAVKYTPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARsRDTGGSGLGLAI 397
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90 100
....*....|....*....|..
gi 515623564 398 VKHALSHHDSHLEIQSEVGVGS 419
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGA 101
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
196-426 |
4.53e-10 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 61.68 E-value: 4.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 196 VTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEdpdmivgpmwtkaHGVMTEQ----LNRMNSLVnqlLTLSKIea 271
Cdd:TIGR03785 475 VARLRQYTHYLENMSSRLSHELRTPVAVVRSSLENLE-------------LQALEQEkqkyLERAREGT---ERLSMI-- 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 272 apMHELDEVVNVPAMLEVLEKE----AASLSG--------DCGHKLEFDIDTSLRVL-ADEDQLRSAISNLVYNAVKYTP 338
Cdd:TIGR03785 537 --LNNMSEATRLEQAIQSAEVEdfdlSEVLSGcmqgyqmtYPPQRFELNIPETPLVMrGSPELIAQMLDKLVDNAREFSP 614
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 339 PGATVRVRWYQTSQGACLDVSDTGDGIePQHLH-RLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLE---IQSE 414
Cdd:TIGR03785 615 EDGLIEVGLSQNKSHALLTVSNEGPPL-PEDMGeQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQaenRQQN 693
|
250
....*....|..
gi 515623564 415 VGVgsRFHFTLP 426
Cdd:TIGR03785 694 DGV--VFRISLP 703
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
305-425 |
4.92e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 57.26 E-value: 4.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 305 LEFDIDTSLRVLADEDQLRSAISNLVYNAVKYTppGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKAR 384
Cdd:cd16954 21 ISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQR 98
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 515623564 385 SrdtgGSGLGLAIVKHALSHHDSHLEI-QSEVGvGSRFHFTL 425
Cdd:cd16954 99 P----GQGLGLAIAKEIVEQYGGELSLsDSPLG-GARFEVVF 135
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
9.79e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 55.62 E-value: 9.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 318 DEDQLRSAISNLVYNA------VKYTPPGATVRVRWYQTSQGAcLDVSDTGDGIEPQHLHRLTERfYRVDKARsrdtgGS 391
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaiegRPSDVGEVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEP-YVTTRPK-----GT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 515623564 392 GLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
1.96e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 54.89 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAVKYTPPGaTVR--VRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrVDKARSRDTG-GSGLGLAIV 398
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPD-TGRitVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSIS 78
|
90 100 110
....*....|....*....|....*....|..
gi 515623564 399 KHALSHHD--SHLEI--QSEVGVGSRFHFTLP 426
Cdd:cd16953 79 RQIIEAHGgiSVAENhnQPGQVIGARFTVQLP 110
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
199-426 |
6.64e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 57.76 E-value: 6.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 199 LKQLEGmrrnffaNVSHELRTPMTVLQGYLE----MTEDPDMIVGPMWTKAHGVmTEQLNRMNSLVNQLLTLSKIEaapm 274
Cdd:PRK13557 163 LGQLTG-------GIAHDFNNLLQVMSGYLDviqaALSHPDADRGRMARSVENI-RAAAERAATLTQQLLAFARKQ---- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 275 hELD-EVVNVPAMLEVLEKEAASLSGDcGHKLEFDIDTSL---RVlaDEDQLRSAISNLVYNAVKYTPPGATVRVR---- 346
Cdd:PRK13557 231 -RLEgRVLNLNGLVSGMGELAERTLGD-AVTIETDLAPDLwncRI--DPTQAEVALLNVLINARDAMPEGGRVTIRtrnv 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 347 ---------WYQTSQG--ACLDVSDTGDGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKHALSHHDSHLEIQSE 414
Cdd:PRK13557 307 eiededlamYHGLPPGryVSIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSE 381
|
250
....*....|..
gi 515623564 415 VGVGSRFHFTLP 426
Cdd:PRK13557 382 VGEGTTVRLYFP 393
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
302-428 |
8.88e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 57.34 E-value: 8.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 302 GHKLEFDIDtslrvlADEDQLRSAI-----SNLVYNAVKY----TPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHR 372
Cdd:COG2972 318 GDRLEVEIE------IDEELLDLLIpklilQPLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEK 391
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 515623564 373 LTERFyrvdkarSRDTGGSGLGLAIVKHALSHH---DSHLEIQSEVGVGSRFHFTLPNR 428
Cdd:COG2972 392 LLEEL-------SSKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRIPLE 443
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-426 |
1.45e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 52.29 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 326 ISNLVYNAVKYT----PPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrvdkaRSRDTGGSGLGLAIVKHA 401
Cdd:cd16915 5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV-----STKGQGERGIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 515623564 402 LSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
300-426 |
7.01e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 54.53 E-value: 7.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 300 DCGHKLEFDIDTSLRVLADEDQ---LRSAISNLVYN---AVKYTPPGA-TVRVRwYQTSQGAClDVSDTGDGIEPQHLHR 372
Cdd:PRK11086 409 ELGITLIISEDSQLPDSGDEDQvheLITILGNLIENaleAVGGEEGGEiSVSLH-YRNGWLHC-EVSDDGPGIAPDEIDA 486
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 515623564 373 LTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK11086 487 IFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
355-426 |
9.63e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 50.07 E-value: 9.63e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515623564 355 CLDVSDTGDGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16919 49 CLEVSDTGSGMPAEVLRRAFEPFFT-----TKEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
98-196 |
1.33e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 49.72 E-value: 1.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPD-------FIKYLNKQDFSEPLEM--P 168
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDdaevaelLRQALLQGEESRGFEVsfR 80
|
90 100 110
....*....|....*....|....*....|...
gi 515623564 169 SPLNVERMLELRIVPYTEGEH-----LMVVRDV 196
Cdd:pfam00989 81 VPDGRPRHVEVRASPVRDAGGeilgfLGVLRDI 113
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
254-426 |
2.67e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 52.60 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 254 NRMNSL--VNQLLTLSK-IEAAPMHELdevvnvpamLEVLEKEAASLSGDCGHKLEFDIDtslRVLADEDQLRS---AIS 327
Cdd:COG3920 338 NRIQALalVHELLYQSEdWEGVDLRDY---------LRELLEPLRDSYGGRGIRIELDGP---DVELPADAAVPlglILN 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 328 NLVYNAVKYTPPGA---TVRVRWYQTSQGACLDVSDTGDGIEPQhlhrlterfyrVDKARSRdtggsGLGLAIVKHALSH 404
Cdd:COG3920 406 ELVTNALKHAFLSGeggRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQ 469
|
170 180
....*....|....*....|..
gi 515623564 405 HDSHLEIQSEVGVgsRFHFTLP 426
Cdd:COG3920 470 LGGTLELDRPEGT--RVRITFP 489
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
98-203 |
3.40e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 51.18 E-value: 3.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLN---------KQDFSEPLEMP 168
Cdd:COG2202 137 ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLEllrrlleggRESYELELRLK 216
|
90 100 110
....*....|....*....|....*....|....*....
gi 515623564 169 SPLNVERMLELRIVPYTEGEH----LMVVRDVTQLKQLE 203
Cdd:COG2202 217 DGDGRWVWVEASAVPLRDGGEvigvLGIVRDITERKRAE 255
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
183-420 |
2.83e-06 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 49.25 E-value: 2.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 183 PYTEGEHLMVVRDVTQLKQLEGMR----RNFFANVSHELRTPMTVLQGYL-EMTEDPDMIVgpmwTKAHGVMTEQLNRMN 257
Cdd:PRK10815 239 PNPPRELTSLVRNLNRLLKNERERytkyRTTLTDLTHSLKTPLAVLQSTLrSLRSGKQMSV----EQAEPIMLEQISRIS 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 258 SLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGDCGHKLEFDIDTSLRVLADEDQLRSAISNLVYNAVKYT 337
Cdd:PRK10815 315 QQIGYYLHRASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYC 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 338 PPGATVRVRwyQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSrdtgGSGLGLAIVKHALSHHDSHLEI-QSEVG 416
Cdd:PRK10815 395 LEFVEISAR--QTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAgDSPLG 468
|
....
gi 515623564 417 vGSR 420
Cdd:PRK10815 469 -GAR 471
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-425 |
3.99e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 45.14 E-value: 3.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 328 NLVYNAV----KYTPPGATVRVRWyqTSQGACLDVSDTGDGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKHAL 402
Cdd:cd16976 7 NLLQNALdamgKVENPRIRIAARR--LGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYGIV 79
|
90 100
....*....|....*....|...
gi 515623564 403 SHHDSHLEIQSEVGVGSRFHFTL 425
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFDL 102
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
290-426 |
4.47e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 47.69 E-value: 4.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 290 LEKEAASLSGDCGHKLEFDIDTSLRVLAD--EDQLRSAISNLVYNAVKYTPpGATVRVRWYQTSQGACLDVSDTGDGIEP 367
Cdd:COG4585 129 LEELAERLLRAAGIRVELDVDGDPDRLPPevELALYRIVQEALTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDP 207
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 515623564 368 QhlhrlterfyrvdkarsrDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:COG4585 208 E------------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
92-203 |
6.65e-06 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 47.33 E-value: 6.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 92 ELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLnkQDFSEPLEMPSPL 171
Cdd:COG2202 5 ALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFL--ELLRAALAGGGVW 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 515623564 172 NVE----------RMLELRIVPYT--EGE---HLMVVRDVTQLKQLE 203
Cdd:COG2202 83 RGElrnrrkdgslFWVELSISPVRdeDGEitgFVGIARDITERKRAE 129
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
320-426 |
7.97e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.90 E-value: 7.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 320 DQLRSAISNLVYNAVKYT---PPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLhrlterfyrvdKARSRDTGGSGLGLA 396
Cdd:COG2172 33 DDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDL-----------PDPYSTLAEGGRGLF 101
|
90 100 110
....*....|....*....|....*....|
gi 515623564 397 IVKhALSHhdsHLEIQSEVGvGSRFHFTLP 426
Cdd:COG2172 102 LIR-RLMD---EVEYESDPG-GTTVRLVKR 126
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
98-152 |
1.22e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 42.77 E-value: 1.22e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 515623564 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDF 152
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDR 55
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
92-203 |
1.31e-05 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 47.07 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 92 ELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQDfSEPLEMPSPL 171
Cdd:COG3829 5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLKTGK-PVTGVIQKTG 83
|
90 100 110
....*....|....*....|....*....|....*.
gi 515623564 172 NVERMLELRIVP-YTEGEHLMVV---RDVTQLKQLE 203
Cdd:COG3829 84 GKGKTVIVTAIPiFEDGEVIGAVetfRDITELKRLE 119
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
325-405 |
1.37e-05 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 43.41 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 325 AISNLVYNAVKYT---PPGATVRVRWYQTSQGACLDVSDTGDGIEPqhlhrlterfyRVDKARSRDTGGSGLGLAIVkHA 401
Cdd:cd16936 4 AVSEAVTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGFDP-----------LRPADPDAGLREGGRGLALI-RA 71
|
....
gi 515623564 402 LSHH 405
Cdd:cd16936 72 LMDE 75
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
320-426 |
1.55e-05 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 45.27 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 320 DQLRSAISNLVYNAV------------KYTPPGATVRVRWYQTSQGACLDVSDTGDGIEP---------------QHLHR 372
Cdd:cd16916 37 EKLADPLTHLLRNAVdhgieapeerlaAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDRekirekaierglitaDEAAT 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515623564 373 LTER----------FYRVDKARsrDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16916 117 LSDDevlnlifapgFSTAEQVT--DVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
107-196 |
2.96e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 43.01 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 107 LPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNK--------QDFSEPLEMPSPLNVERMLE 178
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERlenllsggEPVTLEVRLRRKDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 515623564 179 LRIVPYTEG-----EHLMVVRDV 196
Cdd:cd00130 81 VSLTPIRDEggeviGLLGVVRDI 103
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
98-203 |
3.62e-05 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 43.05 E-value: 3.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIrTPDFI----KYLNKQDFSEPLEMPSPLNV 173
Cdd:TIGR00229 3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELI-PEEDReevrERIERRLEGEPEPVSEERRV 81
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 515623564 174 ------ERMLELRIVP-YTEGEH---LMVVRDVTQLKQLE 203
Cdd:TIGR00229 82 rrkdgsEIWVEVSVSPiRTNGGElgvVGIVRDITERKEAE 121
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-426 |
5.91e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.39 E-value: 5.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 332 NAVKYTPpGATVRVRWYQTSQGACLDVSDTGDGIEPqhlhrlterfyrvdkarSRDTGGSGLGLAIVKHALSHHDSHLEI 411
Cdd:cd16917 11 NALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDG-----------------PAPPGGGGFGLLGMRERAELLGGTLTI 72
|
90
....*....|....*
gi 515623564 412 QSEVGVGSRFHFTLP 426
Cdd:cd16917 73 GSRPGGGTRVTARLP 87
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
7.21e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 42.00 E-value: 7.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 322 LRSAISNLVYNAVKYTPPGA---TVRVRW-YQTSQG------AC-LDVSDTGDGIEPQHLHRLterFYRVDKARSrdtGG 390
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeiILRTRTqRQVTLGhprhrlALrVSVIDNGPGIPPDLQDTI---FYPMVSGRE---NG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 515623564 391 SGLGLAIVKHALSHHDSHLEIQSEVGvGSRFHFTLP 426
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-426 |
1.01e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 41.23 E-value: 1.01e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515623564 358 VSDTGDGIEPQHLHRLTERFYRVDKArsrdtgGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16920 42 VKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
1.09e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 41.26 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 325 AISNLVYNAVKYT----PPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYrvdkarsrdTGGSGLGLAIVK- 399
Cdd:cd16957 5 ALQVLVENAIRHAfpkrKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTV---------TSEKGTGTALENl 75
|
90 100 110
....*....|....*....|....*....|.
gi 515623564 400 ----HALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16957 76 nrrlIGLFGSEACLHIESEVHGGTEVWFVIP 106
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
105-201 |
1.48e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 40.86 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 105 ESLPDAVVVFRGEGNIVWCNKLAQYLLGFR------------WPDDSGQPISNLIRtpdfiKYLNKQDFSEPLEMPSPLN 172
Cdd:pfam08448 2 DSLPDALAVLDPDGRVRYANAAAAELFGLPpeellgktlaelLPPEDAARLERALR-----RALEGEEPIDFLEELLLNG 76
|
90 100 110
....*....|....*....|....*....|....
gi 515623564 173 VERMLELRIVPYTEGE-----HLMVVRDVTQLKQ 201
Cdd:pfam08448 77 EERHYELRLTPLRDPDgevigVLVISRDITERRR 110
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-426 |
1.61e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 40.51 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 329 LVYNAVKY-----TPPGAtVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERfyrvdkarsrDTGGSGLGLAIVKHALS 403
Cdd:cd16924 9 LVENAIQHglsplTDKGV-VTISALKEDNHVMIEVEDNGRGIDPKVLNILGKK----------PKEGNGIGLYNVHQRLI 77
|
90 100
....*....|....*....|....*.
gi 515623564 404 H---HDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16924 78 LlfgEDYGIHIASEPDKGTRITFTIP 103
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
106-426 |
4.72e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 42.61 E-value: 4.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 106 SLPDAVVVFRGEGN-IVWCNKLAQYLLgfrwPDDSGQPISNL-------IRTPdfikylnkqdfseplempspLNVE--- 174
Cdd:PRK10618 351 NLPLGLLVYDFESNrTVISNKIADHLL----PHLNLQKITTMaeqhqgvIQAT--------------------INNElye 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 175 -RMLELRIVPYTegeHLMVVRD------VT---QLKQLE-----GMRRNFFANVSHELRTPMTVLQ------GYLEMTED 233
Cdd:PRK10618 407 iRMFRSQLAPRT---QLFLLRDqdrevlVNkklQQAQREyeknqQARKAFLQNIGDELKQPLQSLAqlaaqlRQTSDEEQ 483
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 234 PDMIVGPMWTKahgvmTEQLNRM--N-SLVNQLLTLS-KIEAAP--MHEL-DEVVnvPAMLEVLEKEAASLSGdcghklE 306
Cdd:PRK10618 484 QQPELDQLAEQ-----SDVLVRLvdNiQLLNMLETQDwKPEQELfsLQDLiDEVL--PEVLPAIKRKGLQLLI------H 550
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 307 FDIDTSLRVLADEDQLRSAISNLVYNAVKYTPPGA-TVRVRWYQTSQGACL-DVSDTGDGIEPQHLHRL---------TE 375
Cdd:PRK10618 551 NHLKAEQLRIGDRDALRKILLLLLNYAITTTAYGKiTLEVDQDESSPDRLTiRILDTGAGVSIKELDNLhfpflnqtqGD 630
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 515623564 376 RFYRvdkarsrdtgGSGLGLAIVKHALSHHDSHLEIQSEVGVGSRFHFTLP 426
Cdd:PRK10618 631 RYGK----------ASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
317-400 |
1.16e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 38.81 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 317 ADEDQLRSAISNLVYNAVKY---TPPGATVRVRWYQTSQGACLDVSDTGDGIEPQHLHRLTErfyrvdKARSRDTGGSGL 393
Cdd:pfam13581 27 ELLDEVELAVGEACTNAVEHayrEGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDL------EEPDEDRKEGGR 100
|
....*..
gi 515623564 394 GLAIVKH 400
Cdd:pfam13581 101 GLALIRG 107
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
1.40e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 37.80 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 325 AISNLVYNAVKY----TPPGATVRVRWYQTSQGACLDVSDTGDGIEPqhlhrlterfyrVDKARSRDTGGSGLGLAIVKH 400
Cdd:cd16956 5 TLQPIVENAVKHglsgLLDGGRVEITARLDGQHLLLEVEDNGGGMDP------------DTLARILIRSSNGLGLNLVDK 72
|
90 100
....*....|....*....|....*....
gi 515623564 401 ALSH---HDSHLEIQSEVGVGSRFHFTLP 426
Cdd:cd16956 73 RLRQafgNDYGLDIECAPGEGTRITIRLP 101
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
98-163 |
4.44e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 35.60 E-value: 4.44e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515623564 98 RRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGfrwPDDSGQPISNLIRTPDFIKYLNKQDFSE 163
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLG---YELLGELLGELLDLLDPLLEDALELLRE 63
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
297-432 |
7.34e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 38.62 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 297 LSGDCGHKLEFDI---DTSL--RVLadeDQLRSAISNLVYNAV--------------KytPPGATVRVRWYQTSQGACLD 357
Cdd:COG0643 251 LARELGKEVELVIegeETELdrTVL---ERLGDPLVHLVRNAVdhgietpeerlaagK--PETGTITLSAYHEGGRVVIE 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515623564 358 VSDTGDGIEPQHLHRlterfyrvdKARSR--------------------------------DTGGSGLGLAIVKHALSHH 405
Cdd:COG0643 326 VSDDGRGLDLEKIRA---------KAIEKglitaeeaaalsdeellelifapgfstaeevtDLSGRGVGMDVVKTNIEAL 396
|
170 180
....*....|....*....|....*..
gi 515623564 406 DSHLEIQSEVGVGSRFHFTLPnrLTVS 432
Cdd:COG0643 397 GGTIEIESEPGKGTTFTLRLP--LTLA 421
|
|
| |
