|
Name |
Accession |
Description |
Interval |
E-value |
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
1-432 |
0e+00 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 870.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 1 MVERLTLKRLAWELAFFYTPWIIVGWIFGYMPWLLFIATALQLAWHLHNQMKLSTWLWDEKRLTPPSGTGNWESLFNGIY 80
Cdd:PRK11006 1 MLERLSWKRLVLELALFCLPALILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLFYGLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 81 RLQQRQRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDFIKYLNKQD 160
Cdd:PRK11006 81 QMQLRNRKRRRELGNLIKRFRSGAESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEFTQYLKTRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 161 FSEPLEMcsPLNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLKGYLEMTEDPDMvVGP 240
Cdd:PRK11006 161 FSRPLTL--VLNNGRHLEIRVMPYTEGQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPL-EGA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 241 MWPKAHGVMTEQLNRMNSLVSQLLTLSKIEAAPMHELDEVVNVPLMLENLEKEAQSLSGDRgHRLDFKIDPKLKVLADED 320
Cdd:PRK11006 238 LREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGK-HTITFEVDNSLKVFGNED 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 321 QLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKH 400
Cdd:PRK11006 317 QLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKH 396
|
410 420 430
....*....|....*....|....*....|..
gi 515621138 401 ALTHHDSHLEIQSTVGIGSKFSFILPSRLIVK 432
Cdd:PRK11006 397 ALSHHDSRLEIESEVGKGTRFSFVLPERLIAK 428
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
93-425 |
0e+00 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 532.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 93 LTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDFIKYLNKQDFSEPLEMCSPLN 172
Cdd:TIGR02966 1 LSALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEFVEYLAAGRFSEPLELPSPIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 173 VERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLKGYLEMTEDPDMVVGPMWPKAHGVMTEQ 252
Cdd:TIGR02966 81 SERVLEIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 253 LNRMNSLVSQLLTLSKIEAAPMHELDEVVNVPLMLENLEKEAQSLSGDRGHRLDFKIDPKLKVLADEDQLRSAISNLVYN 332
Cdd:TIGR02966 161 SQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 333 AVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHLEIQ 412
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIE 320
|
330
....*....|...
gi 515621138 413 STVGIGSKFSFIL 425
Cdd:TIGR02966 321 SELGKGSTFSFIF 333
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
72-426 |
4.97e-99 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 301.09 E-value: 4.97e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 72 WESLFNGIYRLQQRQRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPD 151
Cdd:COG5002 29 LLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 152 FIKYLNKQDFSEPLEMCSPLNVERMLELRIVPYTEGEHLMVV--RDVTQLKQLEGMRRNFFANVSHELRTPMTVLKGYLE 229
Cdd:COG5002 109 ALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAveRDITELERLEQMRREFVANVSHELRTPLTSIRGYLE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 230 MTEDPDMVVGPMWPKAHGVMTEQLNRMNSLVSQLLTLSKIEAAPMHELDEVVNVPLMLENLEKEAQSLSGDRGHRLDFKI 309
Cdd:COG5002 189 LLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 310 -DPKLKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDT 388
Cdd:COG5002 269 pEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRET 348
|
330 340 350
....*....|....*....|....*....|....*...
gi 515621138 389 GGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:COG5002 349 GGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
175-426 |
1.93e-67 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 217.85 E-value: 1.93e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 175 RMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLKGYLEMTEDPdmvVGPMWPKAHGVMTEQLN 254
Cdd:COG0642 79 LLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE---LDEEQREYLETILRSAD 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 255 RMNSLVSQLLTLSKIEAAPMHELDEVVNVPLMLENLEKEAQSLSGDRGHRLDFKIDPKL-KVLADEDQLRSAISNLVYNA 333
Cdd:COG0642 156 RLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNA 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 334 VKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALTHHDSHLEIQS 413
Cdd:COG0642 236 IKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVES 313
|
250
....*....|...
gi 515621138 414 TVGIGSKFSFILP 426
Cdd:COG0642 314 EPGKGTTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
194-426 |
8.61e-66 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 210.53 E-value: 8.61e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 194 RDVTQLKQLEGMRRNFFANVSHELRTPMTVLKGYLEMTEDPDMVVGPMWPKAHGVMTEQLNRMNSLVSQLLTLSKIEAAP 273
Cdd:COG2205 4 EALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 274 MHELDEVVNVPLMLENLEKEAQSLSGDRGHRLDFKIDPKL-KVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQ 352
Cdd:COG2205 84 LSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELpLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGD 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515621138 353 GACLEVSDSGEGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:COG2205 164 GVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
45-429 |
9.03e-54 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 186.33 E-value: 9.03e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 45 WHLHNQMKLSTWLWDEKRLTP-PSGTGNWESLFnGIYRLQQRQRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWC 123
Cdd:COG5809 88 LEFELRHKNGKRLEFSSKLSPiFDQNGDIEGML-AISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYA 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 124 NKLAQHLLGFHWPDDNGQPISNLIRtpDFIKYLNKQDFSEPLEMCSPLNVE----------RMLELRIVPYTEGEH---- 189
Cdd:COG5809 167 NPAACKLLGISIEELIGKSILELIH--SDDQENVAAFISQLLKDGGIAQGEvrfwtkdgrwRLLEASGAPIKKNGEvdgi 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 190 LMVVRDVTQLKQLE-GMRRN--------FFANVSHELRTPMTVLKGYLEMTEDPDMVVGPMWpkaHGVMTEQLNRMNSLV 260
Cdd:COG5809 245 VIIFRDITERKKLEeLLRKSeklsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTY---LDIMLSELDRIESII 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 261 SQLLTLSKIEAAPMHE--LDEVVN--VPLMlenlekEAQSLSgdrgHRLDFKIDPKLK---VLADEDQLRSAISNLVYNA 333
Cdd:COG5809 322 SEFLVLAKPQAIKYEPkdLNTLIEevIPLL------QPQALL----KNVQIELELEDDipdILGDENQLKQVFINLLKNA 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 334 VKYTPEGAEVKVR-WYQSIQGACLEVSDSGEGIEPQHLHRLTERFYrvdkarSRDTGGSGLGLAIVKHALTHHDSHLEIQ 412
Cdd:COG5809 392 IEAMPEGGNITIEtKAEDDDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVE 465
|
410
....*....|....*..
gi 515621138 413 STVGIGSKFSFILPSRL 429
Cdd:COG5809 466 SEVGKGTTFSITLPIKL 482
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-429 |
1.71e-53 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 173.93 E-value: 1.71e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHA 401
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*...
gi 515621138 402 LTHHDSHLEIQSTVGIGSKFSFILPSRL 429
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
76-426 |
2.01e-51 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 178.62 E-value: 2.01e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 76 FNgiyRLQQRQRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIR---TPDF 152
Cdd:COG5000 71 FN---RMTDQLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPeldLAEL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 153 IKYLNKQDFSEPLEMcsPLNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGM-------RRnffanVSHELRTPMTVLK 225
Cdd:COG5000 148 LREALERGWQEEIEL--TRDGRRTLLVRASPLRDDGYVIVFDDITELLRAERLaawgelaRR-----IAHEIKNPLTPIQ 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 226 GYLE---------MTEDPDMVvgpmwPKAHGVMTEQLNRMNSLVSQLLTLSKIEAAPMheldEVVNVPLMLENLEKEAQS 296
Cdd:COG5000 221 LSAErlrrkladkLEEDREDL-----ERALDTIIRQVDRLKRIVDEFLDFARLPEPQL----EPVDLNELLREVLALYEP 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 297 LSGDRGHRLDFKIDPKL-KVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTE 375
Cdd:COG5000 292 ALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFE 371
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 515621138 376 RFYrvdkarSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:COG5000 372 PFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
92-426 |
3.06e-49 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 171.18 E-value: 3.06e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 92 ELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPD-FIKYL-----NKQDFSEP- 164
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSpLRELLeralaEGQPVTERe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 165 LEMCSPLNVERMLELRIVPYTEGEH----LMVVRDVTQLKQLEG-MRRN--------FFANVSHELRTPMTVLKGYLEM- 230
Cdd:COG3852 81 VTLRRKDGEERPVDVSVSPLRDAEGeggvLLVLRDITERKRLEReLRRAeklaavgeLAAGLAHEIRNPLTGIRGAAQLl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 231 -TEDPDmvvgpmwPKAH---GVMTEQLNRMNSLVSQLLTLSKIEAAPMheldEVVNVPLMLENLEKEAQSLSGdRGHRLD 306
Cdd:COG3852 161 eRELPD-------DELReytQLIIEEADRLNNLVDRLLSFSRPRPPER----EPVNLHEVLERVLELLRAEAP-KNIRIV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 307 FKIDPKL-KVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQG----------ACLEVSDSGEGIEPQHLHRLTE 375
Cdd:COG3852 229 RDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprlyVRIEVIDNGPGIPEEILDRIFE 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 515621138 376 RFYrvdkarSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:COG3852 309 PFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
118-426 |
4.34e-46 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 167.62 E-value: 4.34e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 118 GNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDfikylnKQDFSEPLEMCSPLNVERMlelrivpyTEGEHLM------ 191
Cdd:NF033092 278 GRVILINDPALEMLNVSRETVLGQSILDVLGLEE------EYTLRDLLEEQDSLLLDFS--------TEEEPLIlranfs 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 192 --------------VVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLKGYLEMT-----EDPDMVvgpmwPKAHGVMTEQ 252
Cdd:NF033092 344 viqresgfingliaVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALadgawKDPELA-----PRFLGVTQNE 418
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 253 LNRMNSLVSQLLTLSKIEAAPMhELD-EVVNVPLMLEN----LEKEAQSlsgdrgHRLDFKID-PK--LKVLADEDQLRS 324
Cdd:NF033092 419 TERMIRLVNDLLQLSRMDSKDY-KLNkEWVNFNEFFNYiidrFEMILKN------KNITFKREfPKrdLWVEIDTDKITQ 491
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 325 AISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTH 404
Cdd:NF033092 492 VLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEA 571
|
330 340
....*....|....*....|..
gi 515621138 405 HDSHLEIQSTVGIGSKFSFILP 426
Cdd:NF033092 572 HGGRIWAESEEGKGTTIYFTLP 593
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
105-426 |
1.59e-39 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 149.73 E-value: 1.59e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 105 ESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNL-IRTPDFIKYL------NKQDFSEPLEMCSPlnvERML 177
Cdd:PRK11360 269 ESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELfPPNTPFASPLldtlehGTEHVDLEISFPGR---DRTI 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 178 EL----RIVPYTEGE---HLMVVRDVTQLKQL-EGMRR--------NFFANVSHELRTPMTVLKGYLEMTEDPDMvvGPM 241
Cdd:PRK11360 346 ELsvstSLLHNTHGEmigALVIFSDLTERKRLqRRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTS--DPP 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 242 WPKAHGVMTEQLNRMNSLVSQLLTLSKieaaPMHELDEVVNVPLMLENLEKEAQSLSGDRGHRLDFKIDPKL-KVLADED 320
Cdd:PRK11360 424 SQEYLSVVLREVDRLNKVIDQLLEFSR----PRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELpPIWADPE 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 321 QLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQG-ACLEVSDSGEGIEPQHLHRLTERFYRVdKARsrdtgGSGLGLAIVK 399
Cdd:PRK11360 500 LLKQVLLNILINAVQAISARGKIRIRTWQYSDGqVAVSIEDNGCGIDPELLKKIFDPFFTT-KAK-----GTGLGLALSQ 573
|
330 340
....*....|....*....|....*..
gi 515621138 400 HALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:PRK11360 574 RIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
81-426 |
2.36e-36 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 139.48 E-value: 2.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 81 RLQQRQRKKRKELTNLIrrfrngaESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDfikylnKQD 160
Cdd:COG5805 147 KIEEILQEQEERLQTLI-------ENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCD------KEE 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 161 FSEPLEMCSPLNVE--------------RMLELRIVPY--TEGEH---LMVVRDVTQLKQLEGMRRNF---------FAN 212
Cdd:COG5805 214 FKERIESITEVWQEfiiereiitkdgriRYFEAVIVPLidTDGSVkgiLVILRDITEKKEAEELMARSeklsiagqlAAG 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 213 VSHELRTPMTVLKGYLEMtedpdmvvgpMWPKAHG------VMTEQLNRMNSLVSQLLTLSKieaaPMHELDEVVNVPLM 286
Cdd:COG5805 294 IAHEIRNPLTSIKGFLQL----------LQPGIEDkeeyfdIMLSELDRIESIISEFLALAK----PQAVNKEKENINEL 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 287 LENLEK--EAQSLSGDRGHRLDFKiDPKLKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEG 364
Cdd:COG5805 360 IQDVVTllETEAILHNIQIRLELL-DEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIG 438
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515621138 365 IEPQHLHRLTERFYrvdkarSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:COG5805 439 IPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
317-426 |
8.85e-35 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 125.07 E-value: 8.85e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 317 ADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKaRSRDTGGSGLGLA 396
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|
gi 515621138 397 IVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
180-405 |
5.93e-34 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 131.87 E-value: 5.93e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 180 RIVPYTEGEHLMVVRDVTQLKQL----EGMRRNFFANVSHELRTPMTVLKGYLEMTEDPdmvVGPMWPKAHGVMTEQLNR 255
Cdd:NF012163 210 RVTPTSNDELGKLAQDFNQLASTleknEQMRRDFMADISHELRTPLAVLRAELEAIQDG---IRKFTPESLDSLQAEVGT 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 256 MNSLVSQLLTLSKIEAAPM-HELDEVVNVPLMLENLEKEAQSLSgDRGHRLDFKIDPKLKVLADEDQLRSAISNLVYNAV 334
Cdd:NF012163 287 LTKLVDDLHDLSMSDEGALaYQKASVDLVPLLEVEGGAFRERFA-SAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSL 365
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515621138 335 KYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI-VKHALTHH 405
Cdd:NF012163 366 RYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAIsLNIVQAHG 437
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
199-416 |
3.18e-33 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 129.81 E-value: 3.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 199 LKQLE-GMRR--NFFANVSHELRTPMTVLKGYLE--MTEDPDmvvGPMWPKAHGVMTEQLNRMNSLVSQLLTLSKIE--- 270
Cdd:TIGR01386 231 LGRLEdAFQRlsQFSADLAHELRTPLTNLLGQTQvaLSQPRT---GEEYREVLESNLEELERLSRMVSDMLFLARADngq 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 271 -AAPMHELDevvnvplMLENLEKEA---QSLSGDRGHRLDFKIDpkLKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVR 346
Cdd:TIGR01386 308 lALERVRLD-------LAAELAKVAeyfEPLAEERGVRIRVEGE--GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVR 378
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 347 WYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVG 416
Cdd:TIGR01386 379 IERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG 448
|
|
| PhoR |
pfam11808 |
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members ... |
8-90 |
9.42e-33 |
|
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members include PhoR. A member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR is the bifunctional histidine autokinase/phospho-PhoB phosphatase that donates a phosphoryl group to PhoB when environmental Pi is limiting and removes the phosphoryl group from phosphorylated PhoB (PhoB-P) when environmental Pi is abundant.
Pssm-ID: 432090 Cd Length: 84 Bit Score: 118.48 E-value: 9.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 8 KRLAWELAFFYTPWIIVGWIFGYMPWLLFIATALQLAWHLHNQMKLSTWLWDEKRLTPPSGTGNWESLFNGIYRLQQRQR 87
Cdd:pfam11808 2 RRLLWRLALLLLPALLLGLLFGHLAAALLLALLAYLAWHLYQLLRLSRWLWRPRKLTPPDGSGLWGEIFYGLYRLQRRNR 81
|
...
gi 515621138 88 KKR 90
Cdd:pfam11808 82 RRR 84
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
211-426 |
1.67e-31 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 123.37 E-value: 1.67e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 211 ANVSHELRTPMTVLKGYLEMTED--PDMVVGPMWPKAHGVMTEQLNRMNSLVSQLLTLSKIEAAPMheldEVVNVPLMLE 288
Cdd:COG4191 147 AGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEER----EPVDLNELID 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 289 NLEKEAQSLSGDRGHRLDFKIDPKL-KVLADEDQLRSAISNLVYNAVKYTPEGA--EVKVRWYQSIQGACLEVSDSGEGI 365
Cdd:COG4191 223 EALELLRPRLKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRREGDYVVISVRDNGPGI 302
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515621138 366 EPQHLHRLTERFY---RVDKarsrdtgGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:COG4191 303 PPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
210-426 |
3.16e-31 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 124.90 E-value: 3.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 210 FAN-VSHELRTPMTVLKGYLEM-----TEDPDmvvgpmwPKAH---GVMTEQLNRMNSLVSQLLTLSKIEAAPMHEldEV 280
Cdd:COG4251 285 FAYvASHDLREPLRKISGFSQLleedyGDKLD-------EEGReylERIRDAAERMQALIDDLLAYSRVGRQELEF--EP 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 281 VNVPLMLENLEKEAQSLSGDRGhrLDFKIDPKLKVLADEDQLRSAISNLVYNAVKYTPEG--AEVKVRWYQSIQGACLEV 358
Cdd:COG4251 356 VDLNELLEEVLEDLEPRIEERG--AEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSV 433
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515621138 359 SDSGEGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:COG4251 434 RDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
194-428 |
1.58e-30 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 123.21 E-value: 1.58e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 194 RDVTQLKQLEGMRRNFFANVSHELRTPMTVLKgyleMTED------PDMvvGPMWPKAHGVMTEQLNRMNSLVSQLLTLS 267
Cdd:NF040691 259 RQIRQLEELSRLQQRFVSDVSHELRTPLTTIR----MAADvihdsrDDF--DPATARSAELLHTELDRFESLLSDLLEIS 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 268 KIEAAPMhELD-EVVNVPLMLENLEKEAQSLSGDRGHRLDFKIdPKLKVLADED--QLRSAISNLVYNAVKYTpEGAEVK 344
Cdd:NF040691 333 RFDAGAA-ELDvEPVDLRPLVRRVVDALRQLAERAGVELRVDA-PGTPVVAEVDprRVERVLRNLVVNAIEHG-EGKPVV 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 345 VRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFI 424
Cdd:NF040691 410 VTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLT 489
|
....
gi 515621138 425 LPSR 428
Cdd:NF040691 490 LPRV 493
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
208-428 |
1.78e-29 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 119.88 E-value: 1.78e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 208 NFFANVSHELRTPMTVLKGYLEMT--------EDPDMVVGPMwpkahgvmtEQLNRMNSLVSQLLTLSK-------IEAA 272
Cdd:PRK09835 264 NFSADIAHEIRTPITNLITQTEIAlsqsrsqkELEDVLYSNL---------EELTRMAKMVSDMLFLAQadnnqliPEKK 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 273 PMHELDEVVNVPLMLENLEKEaqslsgdRGHRLDFKIDPKLkVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQ 352
Cdd:PRK09835 335 MLDLADEVGKVFDFFEAWAEE-------RGVELRFVGDPCQ-VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDH 406
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515621138 353 GACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVgIGSKFSFILPSR 428
Cdd:PRK09835 407 QVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLPRL 481
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
199-409 |
1.57e-28 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 116.66 E-value: 1.57e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 199 LKQLEGMRRNFFANVSHELRTPMTVLKGYLEMTEDpdmvvgpmwpkahGVMTEQLNRMNSLVSQLLTLSKIeAAPMHEL- 277
Cdd:PRK10549 233 LEKNEQMRRDFMADISHELRTPLAVLRGELEAIQD-------------GVRKFTPESVASLQAEVGTLTKL-VDDLHQLs 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 278 --DE---------VVNVPLmlenLEKEAQSLSG---DRGHRLDFKIDPKLKVLADEDQLRSAISNLVYNAVKYTPEGAEV 343
Cdd:PRK10549 299 lsDEgalayrktpVDLVPL----LEVAGGAFRErfaSRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSL 374
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515621138 344 KVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHL 409
Cdd:PRK10549 375 HISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRI 440
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
317-426 |
9.70e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 105.91 E-value: 9.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 317 ADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSiQGACLEVSDSGEGIEPQHLHRLTERFYRVDKarsRDTGGSGLGLA 396
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 515621138 397 IVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
322-426 |
9.79e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 103.34 E-value: 9.79e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTPEGaEVKVR-WYQSIQGA----CLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLA 396
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEG-EVTLRvSLEEEEEDgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 515621138 397 IVKHaLTH-HDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16922 80 ISKK-LVElMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
202-428 |
1.91e-26 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 111.09 E-value: 1.91e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 202 LEGMRR---------NFFANVSHELRTPMTVLKGYLEMTEDPdmvvgpMWPKAH----GVMTEQLNRMNSLVSQLLTLSK 268
Cdd:PRK11100 243 LESMRVklegkayveQYVQTLTHELKSPLAAIRGAAELLQED------PPPEDRarftGNILTQSARLQQLIDRLLELAR 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 269 IEAapMHELDEVVNVPL--MLENLEKEAQSLSGDRGHRLDFKIDPkLKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVR 346
Cdd:PRK11100 317 LEQ--RQELEVLEPVALaaLLEELVEAREAQAAAKGITLRLRPDD-ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLS 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 347 WYQSIQGACLEVSDSGEGIEPQHLHRLTERFY---RVDKARSrdtgGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSF 423
Cdd:PRK11100 394 AEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATL 469
|
....*
gi 515621138 424 ILPSR 428
Cdd:PRK11100 470 TLPRH 474
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
211-427 |
5.55e-25 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 106.10 E-value: 5.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 211 ANVSHELRTPMTVLKGYLEMTEDPDmvvgPMWPKA---HGVMTEQLNRMNSLVSQLLTLSKieaaPMHELDEVVNVPLML 287
Cdd:COG5806 206 ASIAHEVRNPLTVVRGFIQLLQEPE----LSDEKRkqyIRIALEELDRAEAIITDYLTFAK----PQPEKLEKIDVSEEL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 288 ENLEKEAQSLSGDRGHRLDFKIDPKLKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEP 367
Cdd:COG5806 278 EHVIDVLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTK 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 368 QHLHRLTERFYrvdkarSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILPS 427
Cdd:COG5806 358 EQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-416 |
5.27e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 95.99 E-value: 5.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 318 DEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI 397
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|
gi 515621138 398 V-KHALTHHDSHLEIQSTVG 416
Cdd:cd16946 81 ChNIALAHGGTISAEHSPLG 100
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
16-426 |
7.03e-24 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 102.62 E-value: 7.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 16 FFYTPWIIVGWIFGYMPWLLFIATALQLAWHLHNQMKLSTWLWDEKRLtppsgtgnwesLFNGIYRLQQRQRKKRKELTN 95
Cdd:COG3290 13 ILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLIL-----------LLLLLLLLAALLLKLLEEIAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 96 LIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFhwpDDNGQPISNLIRtpdfiKYLNKQDFSEPLEMCsplnvER 175
Cdd:COG3290 82 LVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLA-----EVLETGERDEEILLN-----GR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 176 MLELRIVPYTEGEHLM----VVRDVTQLK----QLEGMRRnfFANV----SHELRTPMTVLKGYLEMtEDPDmvvgpmwp 243
Cdd:COG3290 149 VLVVNRVPIRDDGRVVgavaTFRDRTELErleeELEGVKE--LAEAlraqRHDFRNHLHTISGLLQL-GEYD-------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 244 KAHGVMTEQLNRMNSLVSQLLTLSKIEAapmheLDEVVnvplmlenLEKEAQSLsgDRGHRLDFKIDPKLKVLA-DEDQL 322
Cdd:COG3290 218 EALEYIDEISEELQELIDSLLSRIGNPV-----LAALL--------LGKAARAR--ERGIDLTIDIDSDLPDLPlSDTDL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 323 RSAISNLVYNAV----KYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRvdkarSRDTGGSGLGLAIV 398
Cdd:COG3290 283 VTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRGLGLALV 357
|
410 420
....*....|....*....|....*...
gi 515621138 399 KHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:COG3290 358 KQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
178-426 |
7.50e-24 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 104.25 E-value: 7.50e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 178 ELRIVPY--TEGEHLMVV---RDVTQLKQ----LEGMRRN---FFANVSHELRTPMTVLKGYLEMTEDPDMVvgpmwpka 245
Cdd:PRK11091 243 ELRKVPFydRVGKRHGLMgfgRDITERKRyqdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLDTELT-------- 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 246 hgvmTEQLNRMNSLVSQLLTLSKI--EAAPMHELD----EVVNVPLMLENLEKEAQSLSG----DRGHRLDFKIDPKL-- 313
Cdd:PRK11091 315 ----AEQRKYLKTIHVSAITLGNIfnDIIDMDKMErrklQLDNQPIDFTDFLADLENLSGlqaeQKGLRFDLEPLLPLph 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 314 KVLADEDQLRSAISNLVYNAVKYTPEGaEVKVR-WYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRV-DKARSRDTGGS 391
Cdd:PRK11091 391 KVITDGTRLRQILWNLISNAVKFTQQG-GVTVRvRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGT 469
|
250 260 270
....*....|....*....|....*....|....*
gi 515621138 392 GLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:PRK11091 470 GIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
212-429 |
1.65e-23 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 101.99 E-value: 1.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 212 NVSHELRTPMTVLKGYLEMTEDPDMvvgpmwpkahgvmTEQ--LNR----MNSLVSQLLTLSKIEAaPMHELD-EVVNVP 284
Cdd:PRK10604 218 GIAHELRTPLVRLRYRLEMSDNLSA-------------AESqaLNRdigqLEALIEELLTYARLDR-PQNELHlSEPDLP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 285 LMLENLEKEAQSLSGDRGHRLDFKIDPKLKVLaDEDQLRSAISNLVYNAVKYtpegAEVKVRWYQSIQG--ACLEVSDSG 362
Cdd:PRK10604 284 AWLSTHLADIQAVTPEKTVRLDTPHQGDYGAL-DMRLMERVLDNLLNNALRY----AHSRVRVSLLLDGnqACLIVEDDG 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515621138 363 EGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILPSRL 429
Cdd:PRK10604 359 PGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWH 425
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
207-412 |
2.68e-23 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 100.43 E-value: 2.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 207 RNFFANVSHELRTPMTVLKGYLEMTEdpdmvvgpmwpKAHGV----MTEQLNRMNSLVSQLLTLSKIEAA-------PMH 275
Cdd:PRK10755 138 RLFTADVAHELRTPLAGIRLHLELLE-----------KQHHIdvapLIARLDQMMHTVEQLLQLARAGQSfssghyqTVK 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 276 ELDEVVnVPLMLEnLEKEAQSlsgdRGHRLDFKIDPK-LKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGA 354
Cdd:PRK10755 207 LLEDVI-LPSQDE-LSEMLEQ----RQQTLLLPESAAdITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGA 280
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 515621138 355 CLEVSDSGEGIEPQHLHRLTERFYRVDkarSRdTGGSGLGLAIVKHALTHHDSHLEIQ 412
Cdd:PRK10755 281 VLAVEDEGPGIDESKCGELSKAFVRMD---SR-YGGIGLGLSIVSRITQLHHGQFFLQ 334
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
314-418 |
1.39e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 92.08 E-value: 1.39e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 314 KVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRwYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKarsRDTGGSGL 393
Cdd:cd16940 6 QVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGL 81
|
90 100
....*....|....*....|....*
gi 515621138 394 GLAIVKHALTHHDSHLEIQSTVGIG 418
Cdd:cd16940 82 GLSIVKRIVELHGGQIFLGNAQGGG 106
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
189-410 |
3.06e-22 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 98.57 E-value: 3.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 189 HLMVVRDvtqlkqlegmrRNFFANVSHELRTPMTVLKGYLEMTE----DPDMVvgpmwPKAHGVMTEQLNRMNSLVSQLL 264
Cdd:PRK10337 231 HAMMVRE-----------RRFTSDAAHELRSPLAALKVQTEVAQlsddDPQAR-----KKALLQLHAGIDRATRLVDQLL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 265 TLSKIEAapMHELDEVVNVPLmlenlEKEAQSLSGDRGHRLD-FKIDPKLKvLADEDQLRSA--------ISNLVYNAVK 335
Cdd:PRK10337 295 TLSRLDS--LDNLQDVAEIPL-----EDLLQSAVMDIYHTAQqAGIDVRLT-LNAHPVIRTGqplllsllVRNLLDNAIR 366
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515621138 336 YTPEGAEVKVRwyqsIQGACLEVSDSGEGIEPQHLHRLTERFYRvdkARSRDTGGSGLGLAIVKHALTHHDSHLE 410
Cdd:PRK10337 367 YSPQGSVVDVT----LNARNFTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVS 434
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-405 |
4.83e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 87.38 E-value: 4.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTPEgaEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHA 401
Cdd:cd16949 1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
....
gi 515621138 402 LTHH 405
Cdd:cd16949 79 IEQH 82
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
211-426 |
1.51e-20 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 93.31 E-value: 1.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 211 ANVSHELRTPMTVLKGYL--------EMTEDPDMVvgpmwpkahGVMTEQLNRMNSLVSQLLTLSKieaaPMH------E 276
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAkyfaerapAGGEAHQLA---------QVMAKEADRLNRVVSELLELVK----PTHlalqavD 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 277 LDEVVNVPLMLenLEKEAQSlsgdRGHRLDFKIDPKLKVL-ADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGAC 355
Cdd:PRK10364 309 LNDLINHSLQL--VSQDANS----REIQLRFTANDTLPEIqADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVK 382
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515621138 356 LEVSDSGEGIEPQHLHRLTERFYrVDKARsrdtgGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:PRK10364 383 ISVTDSGKGIAADQLEAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
211-426 |
5.89e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 92.78 E-value: 5.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 211 ANVSHELRTPMTVLKGYLEMTEDpdmvvGPMWPKAHGVMTEQLNRMNSLVS---QLLTLSKIEAAPMHELDEVVNVPLML 287
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQN-----TPLTAEQMDLADTARQCTLSLLAiinNLLDFSRIESGQMTLSLEETALLPLL 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 288 ENLEKEAQSLSGDRGHRLDFKIDPK--LKVLADEDQLRSAISNLVYNAVKYTPEGaEVKVRWYQSIQGACLEVSDSGEGI 365
Cdd:PRK15347 478 DQAMLTIQGPAQSKSLTLRTFVGAHvpLYLHLDSLRLRQILVNLLGNAVKFTETG-GIRLRVKRHEQQLCFTVEDTGCGI 556
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515621138 366 EPQHLHRLTERFYRVDKarsrDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:PRK15347 557 DIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
213-405 |
8.78e-20 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 91.15 E-value: 8.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 213 VSHELRTPMTVLKgylemtedpdMVVGPMWPKaHGVMTE------QLNRMNSLVSQLLTLSKI--------EAAPMHEL- 277
Cdd:PRK09470 250 ISHELRTPLTRLQ----------LATALLRRR-QGESKElerietEAQRLDSMINDLLVLSRNqqknhlerETFKANSLw 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 278 DEVvnvplmLENLEKEAQSlsgdRGHRLDFKIDPK-LKVLADEDQLRSAISNLVYNAVKYTPEgaEVKVRWYQSIQGACL 356
Cdd:PRK09470 319 SEV------LEDAKFEAEQ----MGKSLTVSAPPGpWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTI 386
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 515621138 357 EVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHH 405
Cdd:PRK09470 387 TVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQH 435
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
193-412 |
1.36e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 90.35 E-value: 1.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 193 VRDVTQ--------LKQLEGMRRNFFANVSHELRTPMTVLKGYLEMtedpdMVVGPMWPKAHgvMTEQLNRMNSLVSQLL 264
Cdd:PRK09467 208 VRSVTRafnqmaagIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEM-----MSEEDGYLAES--INKDIEECNAIIEQFI 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 265 T-LSKIEAAPMHELDevvnvplmLENLEKEAQSLSGDRGHRLDFKIDP-KLKVLADEDQLRSAISNLVYNAVKYTpeGAE 342
Cdd:PRK09467 281 DyLRTGQEMPMEMAD--------LNALLGEVIAAESGYEREIETALQPgPIEVPMNPIAIKRALANLVVNAARYG--NGW 350
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 343 VKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALTHHDSHLEIQ 412
Cdd:PRK09467 351 IKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELG 418
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
5.51e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 81.73 E-value: 5.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTpeGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKArsRDTGGSGLGLAIVKHA 401
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNA--RGTSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 515621138 402 LTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
209-426 |
5.61e-19 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 89.84 E-value: 5.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 209 FFANVSHELRTPMTVLKGYLEMTEDPdmvvgpmwpkahGVMTEQ---LNRMN-------SLVSQLLTLSKIEAAPMHELD 278
Cdd:TIGR02956 467 FLATMSHEIRTPLNGILGTLELLGDT------------GLTSQQqqyLQVINrsgesllDILNDILDYSKIEAGHLSISP 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 279 EVVNVPLMLENLEKEAQSLSGDRGHRLDFKIDPKLK--VLADEDQLRSAISNLVYNAVKYTPEGaEVKVRWYQSIQGACL 356
Cdd:TIGR02956 535 RPFDLNALLDDVHHLMVSRAQLKGIQLRLNIPEQLPnwWQGDGPRIRQVLINLVGNAIKFTDRG-SVVLRVSLNDDSSLL 613
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515621138 357 -EVSDSGEGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:TIGR02956 614 fEVEDTGCGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
318-426 |
1.10e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 81.00 E-value: 1.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 318 DEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACL-EVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLA 396
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLlTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 515621138 397 IVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
74-430 |
2.25e-18 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 87.87 E-value: 2.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 74 SLFNGIYRLQQRQRKK--RKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNlIRTPd 151
Cdd:PRK09959 550 SLLWGFYLLRSVRRRKviQGDLENQISFRKALSDSLPNPTYVVNWQGNVISHNSAFEHYFTADYYKNAMLPLEN-SDSP- 627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 152 fikylNKQDFSEPLEMCSPLNVERMLELRIVPYTEG------------------EHLMVV---RDVTQLKQL---EGMRR 207
Cdd:PRK09959 628 -----FKDVFSNAHEVTAETKENRTIYTQVFEIDNGiekrcinhwhtlcnlpasDHAVYIcgwQDITETRDLihaLEVER 702
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 208 N-----------FFANVSHELRTPMTVLKGYLEMtedpdmVVGPMWPKAHGVMTEQL-----NRMNSLVSQLLTLSKIEA 271
Cdd:PRK09959 703 NkainatvaksqFLATMSHEIRTPISSIMGFLEL------LSGSGLSKEQRVEAISLayatgQSLLGLIGEILDVDKIES 776
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 272 APMHELDEVVNVPLMLENLEKEAQSLSGDRGHRLD----------FKIDPKlkvladedQLRSAISNLVYNAVKYTPEGA 341
Cdd:PRK09959 777 GNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScsstfpdhylVKIDPQ--------AFKQVLSNLLSNALKFTTEGA 848
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 342 eVKVRW--------YQSIQgacLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDtgGSGLGLAIVKHALTHHDSHLEIQS 413
Cdd:PRK09959 849 -VKITTslghiddnHAVIK---MTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLES 922
|
410
....*....|....*..
gi 515621138 414 TVGIGSKFSFILPSRLI 430
Cdd:PRK09959 923 HPGIGTTFTITIPVEIS 939
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
1.46e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 77.75 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTPEG--AEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDkarSRDT-GGSGLGLAIV 398
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEyEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 515621138 399 KHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
203-426 |
2.45e-17 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 84.70 E-value: 2.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 203 EGMRRNFFANVSHELRTPMTVLKGYLEM-TEDPDMVVGPMWPKAHGVMTEQLNrMNSLVSQLLTLSKIEAAPMH------ 275
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEIlTLDLASEGSPHARQASEIRQQVLN-TTRLVNNLLDMARIQSGGFNlrkewl 739
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 276 ELDEVVNVPL-MLENlekeaqSLSgdrGHRLDFKIDPKLKVL-ADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQG 353
Cdd:PRK10490 740 TLEEVVGSALqMLEP------GLS---GHPINLSLPEPLTLIhVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGER 810
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515621138 354 ACLEVSDSGEGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:PRK10490 811 LQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
211-426 |
3.33e-17 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 82.35 E-value: 3.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 211 ANVSHELRTPMTVLKGYLEMTED----PDmvvgpmwPKAHGVMTEQLNRMNSLVSQLLTLSKIEAAPMHELDEVVNVPLM 286
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDgvfePD-------PALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDS 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 287 LENLEKeaqsLSGDRGHRLDFKIDPKL---KVLADEDQLRSAISNLVYNAVKYTPEGaEVKVRWYQSIQGACLEVSDSGE 363
Cdd:NF012226 216 IEKVLK----MFEDRLEQAQLTIVLNLtatPVFCDRRRIEQVLIALIDNAIRYANAG-KLKISSSVIQDDWILQIEDEGP 290
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515621138 364 GIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGiGSKFSFILP 426
Cdd:NF012226 291 GIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQG-NSVFTIKLP 352
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
205-271 |
3.47e-16 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 72.63 E-value: 3.47e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515621138 205 MRRNFFANVSHELRTPMTVLKGYLEMTEDPDmvVGPMWPKAHGVMTEQLNRMNSLVSQLLTLSKIEA 271
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEK--LDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
4.78e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 73.57 E-value: 4.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKarSRDTGGSGLGLAIVKHA 401
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 515621138 402 LTHHDSHLEIQSTvGIGSKFSFILP 426
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
211-426 |
5.43e-16 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 79.22 E-value: 5.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 211 ANVSHELRTPMTVLKGYLEMTE----DPDMVVGP-MWPKAHGVMTEQLNRMNSLVSQLLTLSKIEAApmhELDeVVNVPL 285
Cdd:PRK09303 156 AMLAHDLRTPLTAASLALETLElgqiDEDTELKPaLIEQLQDQARRQLEEIERLITDLLEVGRTRWE---ALR-FNPQKL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 286 MLENLEKEAQSLSGDR--GHRLDFKID-----PKlkVLADEDQLRSAISNLVYNAVKYTPEGAEVKV----RWYQSIQga 354
Cdd:PRK09303 232 DLGSLCQEVILELEKRwlAKSLEIQTDipsdlPS--VYADQERIRQVLLNLLDNAIKYTPEGGTITLsmlhRTTQKVQ-- 307
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515621138 355 cLEVSDSGEGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:PRK09303 308 -VSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
209-426 |
2.44e-15 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 78.48 E-value: 2.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 209 FFANVSHELRTPMTVLKGYLEM------TEDPDMVVGPMwpkahgvmteqlNRMNSL----VSQLLTLSKIEA------- 271
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLlqtkelPKGVDRLVTAM------------NNSSSLllkiISDILDFSKIESeqlkiep 517
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 272 ---APMheldEVVN------VPLMLENlekeaqslsgdrghRLDFK--IDPKLKVLADEDQLR--SAISNLVYNAVKYTP 338
Cdd:PRK10841 518 refSPR----EVINhitanyLPLVVKK--------------RLGLYcfIEPDVPVALNGDPMRlqQVISNLLSNAIKFTD 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 339 EGA---EVKVR-WYQSIQgacleVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHLEIQST 414
Cdd:PRK10841 580 TGCivlHVRVDgDYLSFR-----VRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSE 654
|
250
....*....|..
gi 515621138 415 VGIGSKFSFILP 426
Cdd:PRK10841 655 PGMGSQFTIRIP 666
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
2.46e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 71.55 E-value: 2.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 318 DEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARsRDTGGSGLGLAI 397
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100 110
....*....|....*....|....*....|..
gi 515621138 398 VKHA---LTHhdsHLEIQSTVGIGSKFSFILP 426
Cdd:cd16948 81 VKKLcdkLGH---KIDVESEVGEGTTFTITFP 109
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-412 |
2.57e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.34 E-value: 2.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTgGSGLGLAIVKHA 401
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEV 83
|
90
....*....|.
gi 515621138 402 LTHHDSHLEIQ 412
Cdd:cd16945 84 AQLHGGRITLR 94
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
205-271 |
3.90e-15 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 69.52 E-value: 3.90e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515621138 205 MRRNFFANVSHELRTPMTVLKGYLEMTEDPDMVVGPMwpKAHGVMTEQLNRMNSLVSQLLTLSKIEA 271
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR--EYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
5.78e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 70.54 E-value: 5.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 325 AISNLVYNAVKYtpegAEVKVRWYQSIQG--ACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHAL 402
Cdd:cd16939 4 ALDNLLRNALRY----AHRTVRIALLVSGgrLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....
gi 515621138 403 THHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWP 103
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
213-428 |
1.94e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 75.48 E-value: 1.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 213 VSHELRTPMTVLKGYLEMTEDpdMVvgpmwpKAHGVMTEQL-------NRMNSLVSQLLTLSKIEAAPMH--ELDEVVN- 282
Cdd:PRK13837 457 IAHNFNNILGAILGYAEMALN--KL------ARHSRAARYIdeiisagARARLIIDQILAFGRKGERNTKpfDLSELVTe 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 283 -VPLMlenlekeaqSLSGDRGHRLDFKIDPK-LKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSI--------Q 352
Cdd:PRK13837 529 iAPLL---------RVSLPPGVELDFDQDQEpAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKlrapkvlsH 599
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 353 G-------ACLEVSDSGEGIEPQHLHRLTERFYrvdKARSrdtGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFIL 425
Cdd:PRK13837 600 GvlppgryVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYL 673
|
...
gi 515621138 426 PSR 428
Cdd:PRK13837 674 PPS 676
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
209-428 |
6.42e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 73.79 E-value: 6.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 209 FFANVSHELRTPMTVLKGYLEMTEDpdmvvGPMWPKAHGVMTEQLNRMNSLVSQL---LTLSKIEAAPMHEL--DEVVNV 283
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLAD-----NPALNAQRDDLRAITDSGESLLTILndiLDYSAIEAGGKNVSvsDEPFEP 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 284 PLMLENLEKEAQSLSGDRGHRLDFKIDPKLK--VLADEDQLRSAISNLVYNAVKYTPEGAeVKVRWYQSIQGACLEVSDS 361
Cdd:PRK11466 522 RPLLESTLQLMSGRVKGRPIRLATDIADDLPtaLMGDPRRIRQVITNLLSNALRFTDEGS-IVLRSRTDGEQWLVEVEDS 600
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515621138 362 GEGIEPQHLHRLTERFYRVDKARsrdtGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILPSR 428
Cdd:PRK11466 601 GCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
321-426 |
1.10e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 66.68 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 321 QLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSrdtgGSGLGLAIVKH 400
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 515621138 401 ALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
205-268 |
2.83e-13 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 64.54 E-value: 2.83e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515621138 205 MRRNFFANVSHELRTPMTVLKGYLEMTEDpDMVVGPMWPKAHGVMTEQLNRMNSLVSQLLTLSK 268
Cdd:cd00082 3 AKGEFLANVSHELRTPLTAIRGALELLEE-ELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-423 |
4.96e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.18 E-value: 4.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 318 DEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARsRDTGGSGLGLAI 397
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90 100
....*....|....*....|....*.
gi 515621138 398 VKHALTHHDSHLEIQSTVGIGSKFSF 423
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
105-428 |
1.82e-12 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 68.18 E-value: 1.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 105 ESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDfikyLNKQDFSEPLEMCSPL----------NVE 174
Cdd:PRK11073 14 NSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFS----LNIELMRESLQAGQGFtdnevtlvidGRS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 175 RMLELRIVPYTEGEHLMVVRDVTQLKQL---------EGMRRNFFANVSHELRTPMTVLKGYLEMTED--PDmvvgPMWP 243
Cdd:PRK11073 90 HILSLTAQRLPEGMILLEMAPMDNQRRLsqeqlqhaqQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKalPD----PALT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 244 KAHGVMTEQLNRMNSLVSQLLTLSKIEAAPMHELDEVVNVPLMLENLEKEAQSlsgdrghRLDFKIDPKLKVLA-DEDQL 322
Cdd:PRK11073 166 EYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIHKVAERVVQLVSLELPDNV-------RLIRDYDPSLPELAhDPDQI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 323 RSAISNLVYNAVK-YTPEGAEVKVRW---YQ-SIQG------ACLEVSDSGEGIEPQHLHRLterFYRVDKARSrdtGGS 391
Cdd:PRK11073 239 EQVLLNIVRNALQaLGPEGGTITLRTrtaFQlTLHGeryrlaARIDIEDNGPGIPPHLQDTL---FYPMVSGRE---GGT 312
|
330 340 350
....*....|....*....|....*....|....*..
gi 515621138 392 GLGLAIVKHALTHHDSHLEIQSTVGiGSKFSFILPSR 428
Cdd:PRK11073 313 GLGLSIARNLIDQHSGKIEFTSWPG-HTEFSVYLPIR 348
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
209-429 |
2.02e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 69.11 E-value: 2.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 209 FFANVSHELRTPmtvLKGylemtedpdmVVGpmwpkahgvMTEQL--------------------NRMNSLVSQLLTLSK 268
Cdd:PRK11107 296 FLANMSHELRTP---LNG----------VIG---------FTRQTlktpltptqrdylqtiersaNNLLAIINDILDFSK 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 269 IEAAPM---------HE-LDEVVNvplMLenlekeAQSlSGDRGHRLDFKIDPKL--KVLADEDQLRSAISNLVYNAVKY 336
Cdd:PRK11107 354 LEAGKLvlenipfslREtLDEVVT---LL------AHS-AHEKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKF 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 337 TPEGAeVKVRWY------QSIQGAClEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHLE 410
Cdd:PRK11107 424 TESGN-IDILVElralsnTKVQLEV-QIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDIS 501
|
250
....*....|....*....
gi 515621138 411 IQSTVGIGSKFSFILPSRL 429
Cdd:PRK11107 502 FHSQPNRGSTFWFHLPLDL 520
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
287-399 |
7.83e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 59.57 E-value: 7.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 287 LENLEKEAQSLSGDRGHRLDFKIDPKLKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRwyQSIQGACLEVSDSGEGIE 366
Cdd:cd16954 3 LDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTAR--QTDGGLHLIVDDDGPGVP 80
|
90 100 110
....*....|....*....|....*....|...
gi 515621138 367 PQHLHRLTERFYRVDKARSrdtgGSGLGLAIVK 399
Cdd:cd16954 81 ESQRSKIFQRGQRLDEQRP----GQGLGLAIAK 109
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
310-399 |
1.50e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 58.68 E-value: 1.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 310 DPKLKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSRDTG 389
Cdd:cd16947 9 DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQ 88
|
90
....*....|
gi 515621138 390 GSGLGLAIVK 399
Cdd:cd16947 89 GNGLGLTITK 98
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-426 |
1.91e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 54.60 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 326 ISNLVYNAVKYT----PEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYRvdkarSRDTGGSGLGLAIVKHA 401
Cdd:cd16915 5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 515621138 402 LTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
196-426 |
3.66e-08 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 55.52 E-value: 3.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 196 VTQLKQLEGMRRNFFANVSHELRTPMTVLKGYLEMTEDPDMvvgpmwPKAHgvmTEQLNRMNSLVSqllTLSKIeaapMH 275
Cdd:TIGR03785 475 VARLRQYTHYLENMSSRLSHELRTPVAVVRSSLENLELQAL------EQEK---QKYLERAREGTE---RLSMI----LN 538
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 276 ELDEVVNVPLMLENLEKE----AQSLSG--------DRGHRLDFKIDPKLKVL-ADEDQLRSAISNLVYNAVKYTPEGAE 342
Cdd:TIGR03785 539 NMSEATRLEQAIQSAEVEdfdlSEVLSGcmqgyqmtYPPQRFELNIPETPLVMrGSPELIAQMLDKLVDNAREFSPEDGL 618
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 343 VKVRWYQSIQGACLEVSDSGEGIePQHLH-RLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDSHLEIQSTV-GIGSK 420
Cdd:TIGR03785 619 IEVGLSQNKSHALLTVSNEGPPL-PEDMGeQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQqNDGVV 697
|
....*.
gi 515621138 421 FSFILP 426
Cdd:TIGR03785 698 FRISLP 703
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
183-411 |
3.91e-08 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 55.41 E-value: 3.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 183 PYTEGEHLMVVRDVTQLKQLEGMR----RNFFANVSHELRTPMTVLKGYL-EMTEDPDMVVgpmwPKAHGVMTEQLNRMN 257
Cdd:PRK10815 239 PNPPRELTSLVRNLNRLLKNERERytkyRTTLTDLTHSLKTPLAVLQSTLrSLRSGKQMSV----EQAEPIMLEQISRIS 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 258 SLVSQLLTLSKIEAAPMHELDEVVNVPLMLENLEKEAQSLSGDRGHRLDFKIDPKLKVLADEDQLRSAISNLVYNAVKYT 337
Cdd:PRK10815 315 QQIGYYLHRASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYC 394
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515621138 338 PEGAEVKVRwyQSIQGACLEVSDSGEGIEPQHLHRLTERFYRVDKARSrdtgGSGLGLAIVKHALTHHDSHLEI 411
Cdd:PRK10815 395 LEFVEISAR--QTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISA 462
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
8.58e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 50.23 E-value: 8.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 318 DEDQLRSAISNLVYNAVKyTPEGA-----EVKVRWYQSIQGA-CLEVSDSGEGIEPQHLHRLTERfYRVDKARsrdtgGS 391
Cdd:cd16944 1 DTTQISQVLTNILKNAAE-AIEGRpsdvgEVRIRVEADQDGRiVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 515621138 392 GLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
86-203 |
1.22e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 52.72 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 86 QRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDFIKYLN-------- 157
Cdd:COG2202 125 RKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLEllrrlleg 204
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 515621138 158 -KQDFSEPLEMCSPLNVERMLELRIVPYTEGEH----LMVVRDVTQLKQLE 203
Cdd:COG2202 205 gRESYELELRLKDGDGRWVWVEASAVPLRDGGEvigvLGIVRDITERKRAE 255
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
300-426 |
2.54e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 52.61 E-value: 2.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 300 DRGHRLDFKIDPKLKVLADEDQ---LRSAISNLVYN---AVKYTPEGaEVKVRW-YQSIQGAClEVSDSGEGIEPQHLHR 372
Cdd:PRK11086 409 ELGITLIISEDSQLPDSGDEDQvheLITILGNLIENaleAVGGEEGG-EISVSLhYRNGWLHC-EVSDDGPGIAPDEIDA 486
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 515621138 373 LTERFYrvdkarSRDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:PRK11086 487 IFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-425 |
2.82e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 48.61 E-value: 2.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 328 NLVYNAVKYTPEGAEVKVRWYQSIQG--ACLEVSDSGEGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKHALTH 404
Cdd:cd16976 7 NLLQNALDAMGKVENPRIRIAARRLGgrLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYGIVEE 81
|
90 100
....*....|....*....|.
gi 515621138 405 HDSHLEIQSTVGIGSKFSFIL 425
Cdd:cd16976 82 HGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
3.95e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 48.34 E-value: 3.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTP-EGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYrVDKARSRDTG-GSGLGLAIVK 399
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 515621138 400 HALTHHD--SHLEI--QSTVGIGSKFSFILP 426
Cdd:cd16953 80 QIIEAHGgiSVAENhnQPGQVIGARFTVQLP 110
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
98-196 |
9.46e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 47.41 E-value: 9.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 98 RRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPD-------FIKYLNKQDFSEPLEMC-- 168
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDdaevaelLRQALLQGEESRGFEVSfr 80
|
90 100 110
....*....|....*....|....*....|...
gi 515621138 169 SPLNVERMLELRIVPYTEGEH-----LMVVRDV 196
Cdd:pfam00989 81 VPDGRPRHVEVRASPVRDAGGeilgfLGVLRDI 113
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-426 |
9.82e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 47.01 E-value: 9.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 326 ISNLVYNAVK----YTPEGAEVKVRWYQSIQGAC-LEVSDSGEGIEPQHLHRLTERFYRVDKArsrdtgGSGLGLAIVKH 400
Cdd:cd16920 5 LINLVRNGIEamseGGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICRS 78
|
90 100
....*....|....*....|....*.
gi 515621138 401 ALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
302-426 |
1.61e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 50.02 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 302 GHRLDFKIDpklkvlADEDQLRSAI-----SNLVYNAVKY----TPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHR 372
Cdd:COG2972 318 GDRLEVEIE------IDEELLDLLIpklilQPLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEK 391
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 515621138 373 LTERFyrvdkarSRDTGGSGLGLAIVKHALTHH---DSHLEIQSTVGIGSKFSFILP 426
Cdd:COG2972 392 LLEEL-------SSKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRIP 441
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
92-203 |
1.95e-06 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 49.77 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 92 ELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDFIKYLNKQDfSEPLEMCSPL 171
Cdd:COG3829 5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLKTGK-PVTGVIQKTG 83
|
90 100 110
....*....|....*....|....*....|....*.
gi 515621138 172 NVERMLELRIVP-YTEGEHLMVV---RDVTQLKQLE 203
Cdd:COG3829 84 GKGKTVIVTAIPiFEDGEVIGAVetfRDITELKRLE 119
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
322-426 |
2.21e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 46.22 E-value: 2.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTPEG-------------AEVKVRWYQSIQG--ACLEVSDSGEGIEPQHLHRLTERFYrvdkaRSR 386
Cdd:cd16919 1 LELAILNLAVNARDAMPEGgrltietsnqrvdADYALNYRDLIPGnyVCLEVSDTGSGMPAEVLRRAFEPFF-----TTK 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 515621138 387 DTG-GSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16919 76 EVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
88-203 |
2.49e-06 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 48.48 E-value: 2.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 88 KKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDFIKYL--------NKQ 159
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLellraalaGGG 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 515621138 160 DFSEPLEMCSPLNVERMLELRIVPYT--EGE---HLMVVRDVTQLKQLE 203
Cdd:COG2202 81 VWRGELRNRRKDGSLFWVELSISPVRdeDGEitgFVGIARDITERKRAE 129
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
243-426 |
2.72e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.52 E-value: 2.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 243 PKAHGVMTEQLNRMNSL--VSQLLTLSK-IEAAPMHELdevvnvplmLENLEKEAQSLSGDRGHRLDFKIDPklkVLADE 319
Cdd:COG3920 327 PEAREALEESQNRIQALalVHELLYQSEdWEGVDLRDY---------LRELLEPLRDSYGGRGIRIELDGPD---VELPA 394
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 320 DQLRS---AISNLVYNAVKY---TPEGAEVKVRWYQSIQGACLEVSDSGEGIEPQhlhrlterfyrVDKARSRdtggsGL 393
Cdd:COG3920 395 DAAVPlglILNELVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GL 458
|
170 180 190
....*....|....*....|....*....|...
gi 515621138 394 GLAIVKHALTHHDSHLEIQSTVGIgsKFSFILP 426
Cdd:COG3920 459 GLRLIRALVRQLGGTLELDRPEGT--RVRITFP 489
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
199-419 |
5.11e-06 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 48.51 E-value: 5.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 199 LKQLEGmrrnffaNVSHELRTPMTVLKGYLE----MTEDPDMVVGPMWPKAHGVmTEQLNRMNSLVSQLLTLSKIEaapm 274
Cdd:PRK13557 163 LGQLTG-------GIAHDFNNLLQVMSGYLDviqaALSHPDADRGRMARSVENI-RAAAERAATLTQQLLAFARKQ---- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 275 hELD-EVVNVPLMLENLEKEAQSLSGDrGHRLDFKIDPKLK-VLADEDQLRSAISNLVYNAVKYTPEGAEVKVR------ 346
Cdd:PRK13557 231 -RLEgRVLNLNGLVSGMGELAERTLGD-AVTIETDLAPDLWnCRIDPTQAEVALLNVLINARDAMPEGGRVTIRtrnvei 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 347 ------WYQSIQG---ACLEVSDSGEGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKHALTHHDSHLEIQSTVG 416
Cdd:PRK13557 309 ededlaMYHGLPPgryVSIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVG 383
|
...
gi 515621138 417 IGS 419
Cdd:PRK13557 384 EGT 386
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
98-152 |
5.53e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 43.93 E-value: 5.53e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 515621138 98 RRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDF 152
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDR 55
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
107-215 |
1.36e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 43.78 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 107 LPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDFikylnkQDFSEPLEMCSPLNVERMLELRIVPYtE 186
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDR------EELRERLENLLSGGEPVTLEVRLRRK-D 73
|
90 100
....*....|....*....|....*....
gi 515621138 187 GEHLMVVRDVTQLKQLEGMRRNFFANVSH 215
Cdd:cd00130 74 GSVIWVLVSLTPIRDEGGEVIGLLGVVRD 102
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
213-415 |
2.89e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 46.22 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 213 VSHELRTPMTVLKGYLEMTEDPDMVVGPMWPKAHGVMTEQL-NRMNSLVSQLLTLSKIEAAPMHELD--EVVNVPLMLen 289
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEGLiERMDKIIKSLRQFSRKSDTPLQPVDlrQVIEQAWEL-- 517
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 290 LEKEAQSLSGDrghrldFKIDPKLKVLADEDQLRSAISNLVYNAVKYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEPqh 369
Cdd:COG4192 518 VESRAKPQQIT------LHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL-- 589
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 515621138 370 LHRLTERFYrvdkarSRDTGGSGLGLAIVKHALTHHDSHLEIQSTV 415
Cdd:COG4192 590 VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTL 629
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
98-203 |
2.96e-05 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 43.43 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 98 RRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIrTPDFI----KYLNKQDFSEPLEMCSPLNV 173
Cdd:TIGR00229 3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELI-PEEDReevrERIERRLEGEPEPVSEERRV 81
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 515621138 174 ------ERMLELRIVP-YTEGEH---LMVVRDVTQLKQLE 203
Cdd:TIGR00229 82 rrkdgsEIWVEVSVSPiRTNGGElgvVGIVRDITERKEAE 121
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
325-405 |
4.65e-05 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 41.87 E-value: 4.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 325 AISNLVYNAVKYT---PEGAEVKVRWYQSIQGACLEVSDSGEGIEPqhlhrlterfyRVDKARSRDTGGSGLGLAIVkHA 401
Cdd:cd16936 4 AVSEAVTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGFDP-----------LRPADPDAGLREGGRGLALI-RA 71
|
....
gi 515621138 402 LTHH 405
Cdd:cd16936 72 LMDE 75
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
98-163 |
1.74e-04 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 39.45 E-value: 1.74e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515621138 98 RRFRNGAESLPDAVVVFRSEGNIVWCNKLAQHLLGfhwPDDNGQPISNLIRTPDFIKYLNKQDFSE 163
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLG---YELLGELLGELLDLLDPLLEDALELLRE 63
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
320-416 |
2.16e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 41.05 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 320 DQLRSAISNLVYNAVKYTPEGA---EVKVRWYQSIQGACLEVSDSGEGIEPQHLhrlterfyrvdKARSRDTGGSGLGLA 396
Cdd:COG2172 33 DDLVLAVSEAVTNAVRHAYGGDpdgPVEVELELDPDGLEIEVRDEGPGFDPEDL-----------PDPYSTLAEGGRGLF 101
|
90 100
....*....|....*....|
gi 515621138 397 IVKhALTHhdsHLEIQSTVG 416
Cdd:COG2172 102 LIR-RLMD---EVEYESDPG 117
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
2.16e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 40.49 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 325 AISNLVYNAVKYT----PEGAEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTERFYrvdkarsrdTGGSGLGLAIVK- 399
Cdd:cd16957 5 ALQVLVENAIRHAfpkrKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTV---------TSEKGTGTALENl 75
|
90 100 110
....*....|....*....|....*....|.
gi 515621138 400 ----HALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16957 76 nrrlIGLFGSEACLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
4.74e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 39.69 E-value: 4.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 322 LRSAISNLVYNAVKYTPE-GAEVKVRWYQSIQ----------GACLEVSDSGEGIEPQHLHRLterFYRVDKARSrdtGG 390
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTI---FYPMVSGRE---NG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 515621138 391 SGLGLAIVKHALTHHDSHLEIQSTVGiGSKFSFILP 426
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
105-201 |
5.93e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 39.32 E-value: 5.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 105 ESLPDAVVVFRSEGNIVWCNKLAQHLLGFH------------WPDDNGQPISNLIRtpdfiKYLNKQDFSEPLEMCSPLN 172
Cdd:pfam08448 2 DSLPDALAVLDPDGRVRYANAAAAELFGLPpeellgktlaelLPPEDAARLERALR-----RALEGEEPIDFLEELLLNG 76
|
90 100 110
....*....|....*....|....*....|....
gi 515621138 173 VERMLELRIVPYT--EGE---HLMVVRDVTQLKQ 201
Cdd:pfam08448 77 EERHYELRLTPLRdpDGEvigVLVISRDITERRR 110
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
251-426 |
1.87e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.60 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 251 EQLNRMNSLVSQllTLSKIEAApMHELDEVVNVPLML-ENLEKEAQSLSGDRGHRLDFKIDPKLKVLAD--EDQLRSAIS 327
Cdd:COG4585 92 EELEEIRELARE--ALAELRRL-VRGLRPPALDDLGLaAALEELAERLLRAAGIRVELDVDGDPDRLPPevELALYRIVQ 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 328 NLVYNAVKYTPeGAEVKVRWYQSIQGACLEVSDSGEGIEPQhlhrlterfyrvdkarsrDTGGSGLGLAIVKHALTHHDS 407
Cdd:COG4585 169 EALTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDPE------------------AAPGGGLGLRGMRERAEALGG 229
|
170
....*....|....*....
gi 515621138 408 HLEIQSTVGIGSKFSFILP 426
Cdd:COG4585 230 TLTIGSAPGGGTRVRATLP 248
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
105-161 |
2.68e-03 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 39.79 E-value: 2.68e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 515621138 105 ESLPDAVVVFRSEGNIVWCNKLAQHLLGFHWPDDNGQPISNLIRTPDFIKYLNKQDF 161
Cdd:COG3283 87 EALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLKGFNFSRWLESNEP 143
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
320-426 |
5.98e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 37.56 E-value: 5.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 320 DQLRSAISNLVYNAV------------KYTPEGAEVKVRWYQSIQGACLEVSDSGEGIEP---------------QHLHR 372
Cdd:cd16916 37 EKLADPLTHLLRNAVdhgieapeerlaAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDRekirekaierglitaDEAAT 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515621138 373 LTER----------FYRVDKARsrDTGGSGLGLAIVKHALTHHDSHLEIQSTVGIGSKFSFILP 426
Cdd:cd16916 117 LSDDevlnlifapgFSTAEQVT--DVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
317-400 |
7.00e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 36.50 E-value: 7.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515621138 317 ADEDQLRSAISNLVYNAVKY----TPEGaEVKVRWYQSIQGACLEVSDSGEGIEPQHLHRLTErfyrvdKARSRDTGGSG 392
Cdd:pfam13581 27 ELLDEVELAVGEACTNAVEHayreGPEG-PVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDL------EEPDEDRKEGG 99
|
....*...
gi 515621138 393 LGLAIVKH 400
Cdd:pfam13581 100 RGLALIRG 107
|
|
| |
