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Conserved domains on  [gi|514970778|ref|WP_016659066|]
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MULTISPECIES: chlorhexidine efflux PACE transporter AceI [Acinetobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AceI_fam_PACE NF033663
AceI family chlorhexidine efflux PACE transporter; The AceI family of proton-coupled multidrug ...
 1-136 5.87e-79

AceI family chlorhexidine efflux PACE transporter; The AceI family of proton-coupled multidrug/biocide efflux transporters includes several shown to respond to the presence of the biocide chlorhexidine and improve resistance to it, among other biocides and antibiotics. Members of the family seen so far, including founding member AceI, have been chromosomal and restricted to the genus Acinetobacter.


:

Pssm-ID: 411266  Cd Length: 136  Bit Score: 229.63  E-value: 5.87e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514970778   1 MLLSKRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEARRQLQRTVKVRILHAI 80
Cdd:NF033663   1 MLISKRRLIHALSYEVILLVIIAIALSFIFEMPMEVTGTLGIAMAVTSVIWNMLFNHYFEKFEAKHQLKRTIKVRILHAI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 514970778  81 GFEGGLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAIEVRLDY 136
Cdd:NF033663  81 GFEGGLMLATIPMVAYAMQMSLWQAILLDFGLTLCILVYTFIFQWCYDHIEARLGY 136
 
Name Accession Description Interval E-value
AceI_fam_PACE NF033663
AceI family chlorhexidine efflux PACE transporter; The AceI family of proton-coupled multidrug ...
 1-136 5.87e-79

AceI family chlorhexidine efflux PACE transporter; The AceI family of proton-coupled multidrug/biocide efflux transporters includes several shown to respond to the presence of the biocide chlorhexidine and improve resistance to it, among other biocides and antibiotics. Members of the family seen so far, including founding member AceI, have been chromosomal and restricted to the genus Acinetobacter.


Pssm-ID: 411266  Cd Length: 136  Bit Score: 229.63  E-value: 5.87e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514970778   1 MLLSKRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEARRQLQRTVKVRILHAI 80
Cdd:NF033663   1 MLISKRRLIHALSYEVILLVIIAIALSFIFEMPMEVTGTLGIAMAVTSVIWNMLFNHYFEKFEAKHQLKRTIKVRILHAI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 514970778  81 GFEGGLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAIEVRLDY 136
Cdd:NF033663  81 GFEGGLMLATIPMVAYAMQMSLWQAILLDFGLTLCILVYTFIFQWCYDHIEARLGY 136
COG4125 COG4125
Uncharacterized membrane protein [Function unknown];
5-130 9.01e-49

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 443301  Cd Length: 144  Bit Score: 153.45  E-value: 9.01e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514970778   5 KRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEAR-RQLQRTVKVRILHAIGFE 83
Cdd:COG4125    5 KERIRHAVLFELIALLISAPLLAWLFGKSLGDMGALAVVLSTIAMLWNYIYNWLFDRWERRqRGVRRTLRVRILHALGFE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 514970778  84 GGLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAI 130
Cdd:COG4125   85 GGLLLILVPLIAWWLGISLWEALLLDIGLLLFFLVYTFVFNWAYDRL 131
PACE_transport NF033664
PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter ...
 5-130 3.22e-42

PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter AceI, average about 140 amino acids in length and consist of two tandem homologous domains described by Pfam model PF05232. PACE transporters are single component efflux transporters that sit in the plasma membrane and couple proton import to substrate export.


Pssm-ID: 411267 [Multi-domain]  Cd Length: 130  Bit Score: 136.15  E-value: 3.22e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514970778   5 KRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEARRQLQRTVKVRILHAIGFEG 84
Cdd:NF033664   3 KERIVHAVLFEVIAILISAPLLAWLMGRSLSHSGALAVMISTIAMLWNMIYNALFERWERRQRVRRRTVRRVLHAIGFEG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 514970778  85 GLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAI 130
Cdd:NF033664  83 GLVLILVPLAAWWLGISLLEAFLLDIGLLLFFLPYTFVFNWAFDKL 128
PACE_efflu_PCE NF033665
multidrug/biocide efflux PACE transporter; PACE (proteobacterial antimicrobial compound efflux) ...
 5-130 1.06e-33

multidrug/biocide efflux PACE transporter; PACE (proteobacterial antimicrobial compound efflux) transporters are single component proton-coupled efflux pumps that help confer resistance to a number of biocides and antibiotics. The family has also been named PCE (proteobacterial chlorhexidine efflux). Members of this subfamily of the PACE transporters, distinct from the AceI-like branch, include several whose expression is increased by exposure to chlorhexidine and/or help confer increased resistance to it.


Pssm-ID: 411268  Cd Length: 130  Bit Score: 114.64  E-value: 1.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514970778   5 KRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEARRQLQRTVKVRILHAIGFEG 84
Cdd:NF033665   3 TERIFHAVGFEGIAVLICAPLLAWLMDRSLLEMGALTIMLSTVAMLWNMIYNALFDRLWPRLGVARTLKVRVLHALGFEG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 514970778  85 GLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAI 130
Cdd:NF033665  83 GLILIGVPLAAWWLGISLLQAFLLEIGFFLFFLPYTMVYNWAYDKL 128
BTP pfam05232
Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane ...
 70-133 1.01e-16

Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane alpha-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and there is an increasing problem with resistance to it in some pathogenic bacteria. BTP is localized in the cytoplasmic membrane.


Pssm-ID: 428384  Cd Length: 64  Bit Score: 69.45  E-value: 1.01e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514970778   70 RTVKVRILHAIGFEGGLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAIEVR 133
Cdd:pfam05232   1 RSLKRRVLHALLFELGLLLLLVPLLAWLLGVSLGEAGVLDIGLSLFAMVWNFVFNWLFDRLFPR 64
 
Name Accession Description Interval E-value
AceI_fam_PACE NF033663
AceI family chlorhexidine efflux PACE transporter; The AceI family of proton-coupled multidrug ...
 1-136 5.87e-79

AceI family chlorhexidine efflux PACE transporter; The AceI family of proton-coupled multidrug/biocide efflux transporters includes several shown to respond to the presence of the biocide chlorhexidine and improve resistance to it, among other biocides and antibiotics. Members of the family seen so far, including founding member AceI, have been chromosomal and restricted to the genus Acinetobacter.


Pssm-ID: 411266  Cd Length: 136  Bit Score: 229.63  E-value: 5.87e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514970778   1 MLLSKRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEARRQLQRTVKVRILHAI 80
Cdd:NF033663   1 MLISKRRLIHALSYEVILLVIIAIALSFIFEMPMEVTGTLGIAMAVTSVIWNMLFNHYFEKFEAKHQLKRTIKVRILHAI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 514970778  81 GFEGGLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAIEVRLDY 136
Cdd:NF033663  81 GFEGGLMLATIPMVAYAMQMSLWQAILLDFGLTLCILVYTFIFQWCYDHIEARLGY 136
COG4125 COG4125
Uncharacterized membrane protein [Function unknown];
5-130 9.01e-49

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 443301  Cd Length: 144  Bit Score: 153.45  E-value: 9.01e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514970778   5 KRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEAR-RQLQRTVKVRILHAIGFE 83
Cdd:COG4125    5 KERIRHAVLFELIALLISAPLLAWLFGKSLGDMGALAVVLSTIAMLWNYIYNWLFDRWERRqRGVRRTLRVRILHALGFE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 514970778  84 GGLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAI 130
Cdd:COG4125   85 GGLLLILVPLIAWWLGISLWEALLLDIGLLLFFLVYTFVFNWAYDRL 131
PACE_transport NF033664
PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter ...
 5-130 3.22e-42

PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter AceI, average about 140 amino acids in length and consist of two tandem homologous domains described by Pfam model PF05232. PACE transporters are single component efflux transporters that sit in the plasma membrane and couple proton import to substrate export.


Pssm-ID: 411267 [Multi-domain]  Cd Length: 130  Bit Score: 136.15  E-value: 3.22e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514970778   5 KRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEARRQLQRTVKVRILHAIGFEG 84
Cdd:NF033664   3 KERIVHAVLFEVIAILISAPLLAWLMGRSLSHSGALAVMISTIAMLWNMIYNALFERWERRQRVRRRTVRRVLHAIGFEG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 514970778  85 GLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAI 130
Cdd:NF033664  83 GLVLILVPLAAWWLGISLLEAFLLDIGLLLFFLPYTFVFNWAFDKL 128
PACE_efflu_PCE NF033665
multidrug/biocide efflux PACE transporter; PACE (proteobacterial antimicrobial compound efflux) ...
 5-130 1.06e-33

multidrug/biocide efflux PACE transporter; PACE (proteobacterial antimicrobial compound efflux) transporters are single component proton-coupled efflux pumps that help confer resistance to a number of biocides and antibiotics. The family has also been named PCE (proteobacterial chlorhexidine efflux). Members of this subfamily of the PACE transporters, distinct from the AceI-like branch, include several whose expression is increased by exposure to chlorhexidine and/or help confer increased resistance to it.


Pssm-ID: 411268  Cd Length: 130  Bit Score: 114.64  E-value: 1.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514970778   5 KRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEARRQLQRTVKVRILHAIGFEG 84
Cdd:NF033665   3 TERIFHAVGFEGIAVLICAPLLAWLMDRSLLEMGALTIMLSTVAMLWNMIYNALFDRLWPRLGVARTLKVRVLHALGFEG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 514970778  85 GLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAI 130
Cdd:NF033665  83 GLILIGVPLAAWWLGISLLQAFLLEIGFFLFFLPYTMVYNWAYDKL 128
BTP pfam05232
Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane ...
 70-133 1.01e-16

Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane alpha-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and there is an increasing problem with resistance to it in some pathogenic bacteria. BTP is localized in the cytoplasmic membrane.


Pssm-ID: 428384  Cd Length: 64  Bit Score: 69.45  E-value: 1.01e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514970778   70 RTVKVRILHAIGFEGGLMLATIPMVAYAMQMSLPEAFLLDLSLTLCILVYTFIFQWGYDAIEVR 133
Cdd:pfam05232   1 RSLKRRVLHALLFELGLLLLLVPLLAWLLGVSLGEAGVLDIGLSLFAMVWNFVFNWLFDRLFPR 64
BTP pfam05232
Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane ...
 5-65 3.51e-11

Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane alpha-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and there is an increasing problem with resistance to it in some pathogenic bacteria. BTP is localized in the cytoplasmic membrane.


Pssm-ID: 428384  Cd Length: 64  Bit Score: 55.20  E-value: 3.51e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514970778    5 KRRLIHALSYELILLVIIALALSLIFKMPLEVTGSLGVAMAVTSVLWNMLFNHFFEKFEAR 65
Cdd:pfam05232   4 KRRVLHALLFELGLLLLLVPLLAWLLGVSLGEAGVLDIGLSLFAMVWNFVFNWLFDRLFPR 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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