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Conserved domains on  [gi|510918145|ref|WP_016239126|]
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MULTISPECIES: site-specific integrase [Enterobacteriaceae]

Protein Classification

site-specific integrase( domain architecture ID 10457031)

tyrosine based site-specific recombinase (integrase) is involved in cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct

CATH:  1.10.443.10
Gene Ontology:  GO:0015074|GO:0003677|GO:0006310
PubMed:  10047575|9278480|10577069
SCOP:  4002347

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phage_integrase pfam00589
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ...
 42-233 9.47e-36

Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.


:

Pssm-ID: 395471 [Multi-domain]  Cd Length: 169  Bit Score: 125.12  E-value: 9.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145   42 YLLAPEVSALLHYVPD----LRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFV-QLATLKQRTekaartagrmpag 116
Cdd:pfam00589   1 RLTEDEVERLLDAAETgplsIRDKALLELLYATGLRISELCSLRWSDIDFENGVIRVhRGKGNKERT------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  117 qqthrlVPLSDSwYVSQLQTMVATLkipMERRNKRTGRTEKARIWEVTDRTVRTWIGEAVAAAAADgvtfsVPVTPHTFR 196
Cdd:pfam00589  68 ------VPLSDA-ALELLKEWLSKR---LLEAPKSDYLFASKRGKPLSRQTVRKIFKRAGKEAGLE-----LPLHPHMLR 132

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 510918145  197 HSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVFA 233
Cdd:pfam00589 133 HSFATHLLEAGVDLRVVQKLLGHSSISTTQIYTHVAD 169
 
Name Accession Description Interval E-value
Phage_integrase pfam00589
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ...
 42-233 9.47e-36

Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.


Pssm-ID: 395471 [Multi-domain]  Cd Length: 169  Bit Score: 125.12  E-value: 9.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145   42 YLLAPEVSALLHYVPD----LRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFV-QLATLKQRTekaartagrmpag 116
Cdd:pfam00589   1 RLTEDEVERLLDAAETgplsIRDKALLELLYATGLRISELCSLRWSDIDFENGVIRVhRGKGNKERT------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  117 qqthrlVPLSDSwYVSQLQTMVATLkipMERRNKRTGRTEKARIWEVTDRTVRTWIGEAVAAAAADgvtfsVPVTPHTFR 196
Cdd:pfam00589  68 ------VPLSDA-ALELLKEWLSKR---LLEAPKSDYLFASKRGKPLSRQTVRKIFKRAGKEAGLE-----LPLHPHMLR 132

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 510918145  197 HSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVFA 233
Cdd:pfam00589 133 HSFATHLLEAGVDLRVVQKLLGHSSISTTQIYTHVAD 169
XerD COG4974
Site-specific recombinase XerD [Replication, recombination and repair];
39-231 5.10e-26

Site-specific recombinase XerD [Replication, recombination and repair];


Pssm-ID: 443999 [Multi-domain]  Cd Length: 291  Bit Score: 103.15  E-value: 5.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  39 LPKYLLAPEVSALLHYVPD-----LRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFVqlatlkqRTEKAARTagrm 113
Cdd:COG4974  109 LPRVLTEEEIEALLEALDTetpegLRDRALLLLLYATGLRVSELLGLKWSDIDLDRGTIRV-------RRGKGGKE---- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 114 pagqqthRLVPLSDSWyVSQLQTMVATLKIPMER---RNKRTGRtekariweVTDRTVRTWIGEAVAAaaadgVTFSVPV 190
Cdd:COG4974  178 -------RTVPLSPEA-LEALREYLEERRPRDSDylfPTRRGRP--------LSRRAIRKILKRLAKR-----AGIPKRV 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 510918145 191 TPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:COG4974  237 TPHSLRHTFATHLLEAGVDLRTVQELLGHSSISTTQIYTHV 277
INT_IntI_C cd01193
Integron integrase and similar protiens, C-terminal catalytic domain; Integron integrases ...
 39-231 2.00e-22

Integron integrase and similar protiens, C-terminal catalytic domain; Integron integrases mediate site-specific DNA recombination between a proximal primary site (attI) and a secondary target site (attC) found within mobile gene cassettes encoding resistance or virulence factors. Unlike other site specific recombinases, the attC sites lack sequence conservation. Integron integrase exhibits broader DNA specificity by recognizing the non-conserved attC sites. The structure shows that DNA target site recognition are not dependent on canonical DNA but on the position of two flipped-out bases that interact in cis and in trans with the integrase. Integron-integrases are present in many natural occurring mobile elements, including transposons and conjugative plasmids. Vibrio, Shewanella, Xanthomonas, and Pseudomonas species harbor chromosomal super-integrons. All integron-integrases carry large inserts unlike the TnpF ermF-like proteins also seen in this group.


Pssm-ID: 271193 [Multi-domain]  Cd Length: 176  Bit Score: 90.80  E-value: 2.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  39 LPKYLLAPEVSALLHYVPDLRRKMLLATLWNTGARINEALALTRGDFSLTPpypfvqlATLKQRTEKAARtagrmpagqq 118
Cdd:cd01193    2 LPVVLSPDEVRRILGALTELRHRLILSLLYGAGLRISELLRLRVKDIDFER-------GVIRVRQGKGGK---------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 119 tHRLVPLSDSwYVSQLQTMVATLKIPME--RRNKRTGRTEKARIWE----VTDRTVRTWIGEAVAAAaadGVTfsVPVTP 192
Cdd:cd01193   65 -DRVVPLPEK-LLEPLRRYLKSARPKEEldPAEGRAGVLDPRTGVErrhhISETTVQRALKKAVEQA---GIT--KRVTP 137

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 510918145 193 HTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:cd01193  138 HTLRHSFATHLLEAGTDIRTIQELLGHSDLSTTMIYTHV 176
recomb_XerD TIGR02225
tyrosine recombinase XerD; The phage integrase family describes a number of recombinases with ...
 39-231 6.04e-19

tyrosine recombinase XerD; The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerD, one of two closely related chromosomal proteins along with XerC (TIGR02224). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and with homologs of XerD on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerD, as some apparent XerD examples score below the trusted and noise cutoff scores. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274043 [Multi-domain]  Cd Length: 291  Bit Score: 83.79  E-value: 6.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145   39 LPKYLLAPEVSALLHYVP-----DLRRKMLLATLWNTGARINEALALTRGDFSLTppypfvqlatlkqrtEKAARTAGRm 113
Cdd:TIGR02225 101 LPKVLTVEEVEALLAAPDvdtplGLRDRAMLELLYATGLRVSELVGLRLEDVNLD---------------EGFVRVRGK- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  114 pAGQQthRLVPLSD---SW---YVSQLQTMVATLKIPMERR---NKRTGRTEKARIWE-VTDRTVRTWIGEavaaaaadg 183
Cdd:TIGR02225 165 -GNKE--RLVPLGEeaiEAlerYLKEARPLLLKKKVKESDAlflNRRGGPLSRQGVWKiLKEYAKRAGIEK--------- 232

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 510918145  184 vtfsvPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:TIGR02225 233 -----PISPHTLRHSFATHLLENGADLRVVQELLGHADISTTQIYTHV 275
xerC PRK00236
site-specific tyrosine recombinase XerC; Reviewed
 39-231 1.05e-13

site-specific tyrosine recombinase XerC; Reviewed


Pssm-ID: 234698 [Multi-domain]  Cd Length: 297  Bit Score: 69.41  E-value: 1.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  39 LPKYLLAPEVSALLHYVPD-----LRRKMLLATLWNTGARINEALALTRGDFSLtppypfvQLATL-------KQRTeka 106
Cdd:PRK00236 112 LPKPLDVDQAKRLLDAIDEddplaLRDRAILELLYGSGLRLSELVGLDIDDLDL-------ASGTLrvlgkgnKERT--- 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 107 artagrmpagqqthrlVPLSDswYVSQ-LQTMVATLKIPMER-----RNKRTGRTEKARIwevtDRTVRTWIGEAvaaaa 180
Cdd:PRK00236 182 ----------------VPLGR--AAREaLEAYLALRPLFLPDddalfLGARGGRLSPRVV----QRRVKKLGKKA----- 234

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 510918145 181 adGVTFSVpvTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:PRK00236 235 --GLPSHI--TPHKLRHSFATHLLESGGDLRAVQELLGHASLSTTQIYTHV 281
recomb_GmtY NF040693
gamma-mobile-trio recombinase GmtY; GmtY (gamma-mobile-trio system tyrosine recombinase) is a ...
 191-238 2.86e-05

gamma-mobile-trio recombinase GmtY; GmtY (gamma-mobile-trio system tyrosine recombinase) is a putative integrase regularly found associated with two other proteins of unknown function, in a cassette found sporadically in various Gamma-proteobacteria. Members of this family include VPA1270, found in pathogenicity island 6 of Vibrio parahaemolyticus RIMD2210633.


Pssm-ID: 468657 [Multi-domain]  Cd Length: 441  Bit Score: 44.91  E-value: 2.86e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 510918145 191 TPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVFALDVAA 238
Cdd:NF040693 392 TPHGHRHAYGRRLRNAGVDPLEIQKAMHHKSPESQLVYTQPTAAEVRA 439
 
Name Accession Description Interval E-value
Phage_integrase pfam00589
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ...
 42-233 9.47e-36

Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.


Pssm-ID: 395471 [Multi-domain]  Cd Length: 169  Bit Score: 125.12  E-value: 9.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145   42 YLLAPEVSALLHYVPD----LRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFV-QLATLKQRTekaartagrmpag 116
Cdd:pfam00589   1 RLTEDEVERLLDAAETgplsIRDKALLELLYATGLRISELCSLRWSDIDFENGVIRVhRGKGNKERT------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  117 qqthrlVPLSDSwYVSQLQTMVATLkipMERRNKRTGRTEKARIWEVTDRTVRTWIGEAVAAAAADgvtfsVPVTPHTFR 196
Cdd:pfam00589  68 ------VPLSDA-ALELLKEWLSKR---LLEAPKSDYLFASKRGKPLSRQTVRKIFKRAGKEAGLE-----LPLHPHMLR 132

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 510918145  197 HSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVFA 233
Cdd:pfam00589 133 HSFATHLLEAGVDLRVVQKLLGHSSISTTQIYTHVAD 169
XerD COG4974
Site-specific recombinase XerD [Replication, recombination and repair];
39-231 5.10e-26

Site-specific recombinase XerD [Replication, recombination and repair];


Pssm-ID: 443999 [Multi-domain]  Cd Length: 291  Bit Score: 103.15  E-value: 5.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  39 LPKYLLAPEVSALLHYVPD-----LRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFVqlatlkqRTEKAARTagrm 113
Cdd:COG4974  109 LPRVLTEEEIEALLEALDTetpegLRDRALLLLLYATGLRVSELLGLKWSDIDLDRGTIRV-------RRGKGGKE---- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 114 pagqqthRLVPLSDSWyVSQLQTMVATLKIPMER---RNKRTGRtekariweVTDRTVRTWIGEAVAAaaadgVTFSVPV 190
Cdd:COG4974  178 -------RTVPLSPEA-LEALREYLEERRPRDSDylfPTRRGRP--------LSRRAIRKILKRLAKR-----AGIPKRV 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 510918145 191 TPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:COG4974  237 TPHSLRHTFATHLLEAGVDLRTVQELLGHSSISTTQIYTHV 277
INT_IntI_C cd01193
Integron integrase and similar protiens, C-terminal catalytic domain; Integron integrases ...
 39-231 2.00e-22

Integron integrase and similar protiens, C-terminal catalytic domain; Integron integrases mediate site-specific DNA recombination between a proximal primary site (attI) and a secondary target site (attC) found within mobile gene cassettes encoding resistance or virulence factors. Unlike other site specific recombinases, the attC sites lack sequence conservation. Integron integrase exhibits broader DNA specificity by recognizing the non-conserved attC sites. The structure shows that DNA target site recognition are not dependent on canonical DNA but on the position of two flipped-out bases that interact in cis and in trans with the integrase. Integron-integrases are present in many natural occurring mobile elements, including transposons and conjugative plasmids. Vibrio, Shewanella, Xanthomonas, and Pseudomonas species harbor chromosomal super-integrons. All integron-integrases carry large inserts unlike the TnpF ermF-like proteins also seen in this group.


Pssm-ID: 271193 [Multi-domain]  Cd Length: 176  Bit Score: 90.80  E-value: 2.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  39 LPKYLLAPEVSALLHYVPDLRRKMLLATLWNTGARINEALALTRGDFSLTPpypfvqlATLKQRTEKAARtagrmpagqq 118
Cdd:cd01193    2 LPVVLSPDEVRRILGALTELRHRLILSLLYGAGLRISELLRLRVKDIDFER-------GVIRVRQGKGGK---------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 119 tHRLVPLSDSwYVSQLQTMVATLKIPME--RRNKRTGRTEKARIWE----VTDRTVRTWIGEAVAAAaadGVTfsVPVTP 192
Cdd:cd01193   65 -DRVVPLPEK-LLEPLRRYLKSARPKEEldPAEGRAGVLDPRTGVErrhhISETTVQRALKKAVEQA---GIT--KRVTP 137

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 510918145 193 HTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:cd01193  138 HTLRHSFATHLLEAGTDIRTIQELLGHSDLSTTMIYTHV 176
DNA_BRE_C cd00397
DNA breaking-rejoining enzymes, C-terminal catalytic domain; The DNA breaking-rejoining enzyme ...
 56-229 1.38e-21

DNA breaking-rejoining enzymes, C-terminal catalytic domain; The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271175 [Multi-domain]  Cd Length: 167  Bit Score: 88.31  E-value: 1.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  56 PDLRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFVqlatlkqRTEKAARTagrmpagqqTHRLVPLSDSWYVSQLQ 135
Cdd:cd00397   15 IDLRDRAILLLLLETGLRISELLALKVKDIDLDNGTIRV-------RGKKTKGG---------KERTVPLPKELAEELKE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 136 --TMVATLKIPMERRNKRTGRTEKARIWEVTDRTVRTWIGEAvaaaaadGVTFSVPVTPHTFRHSYAMHMLYAGIPLKVL 213
Cdd:cd00397   79 ylKERRDKRGPLLKSLYLNKLFGTKLGERLSRRTLRRIFKKA-------GIEAGRKITPHSLRHTFATNLLENGVDIKVV 151

                        170
                 ....*....|....*.
gi 510918145 214 QSLMGHKSISSTEVYT 229
Cdd:cd00397  152 QKLLGHSSISTTQRYL 167
recomb_XerD TIGR02225
tyrosine recombinase XerD; The phage integrase family describes a number of recombinases with ...
 39-231 6.04e-19

tyrosine recombinase XerD; The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerD, one of two closely related chromosomal proteins along with XerC (TIGR02224). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and with homologs of XerD on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerD, as some apparent XerD examples score below the trusted and noise cutoff scores. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274043 [Multi-domain]  Cd Length: 291  Bit Score: 83.79  E-value: 6.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145   39 LPKYLLAPEVSALLHYVP-----DLRRKMLLATLWNTGARINEALALTRGDFSLTppypfvqlatlkqrtEKAARTAGRm 113
Cdd:TIGR02225 101 LPKVLTVEEVEALLAAPDvdtplGLRDRAMLELLYATGLRVSELVGLRLEDVNLD---------------EGFVRVRGK- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  114 pAGQQthRLVPLSD---SW---YVSQLQTMVATLKIPMERR---NKRTGRTEKARIWE-VTDRTVRTWIGEavaaaaadg 183
Cdd:TIGR02225 165 -GNKE--RLVPLGEeaiEAlerYLKEARPLLLKKKVKESDAlflNRRGGPLSRQGVWKiLKEYAKRAGIEK--------- 232

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 510918145  184 vtfsvPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:TIGR02225 233 -----PISPHTLRHSFATHLLENGADLRVVQELLGHADISTTQIYTHV 275
INT_XerDC_C cd00798
XerD and XerC integrases, C-terminal catalytic domains; XerDC-like integrases are involved in ...
 47-231 3.79e-18

XerD and XerC integrases, C-terminal catalytic domains; XerDC-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance. They share the same fold in their catalytic domain containing six conserved active site residues and the overall reaction mechanism with the DNA breaking-rejoining enzyme superfamily. In Escherichia coli, the Xer site-specific recombination system acts to convert dimeric chromosomes, which are formed by homologous recombination to monomers. Two related recombinases, XerC and XerD, bind cooperatively to a recombination site present in the E. coli chromosome. Each recombinase catalyzes the exchange of one pair of DNA strand in a reaction that proceeds through a Holliday junction intermediate. These enzymes can bridge two different and well-separated DNA sequences called arm- and core-sites. The C-terminal domain binds, cleaves, and re-ligates DNA strands at the core-sites, while the N-terminal domain is largely responsible for high-affinity binding to the arm-type sites.


Pssm-ID: 271179 [Multi-domain]  Cd Length: 172  Bit Score: 79.09  E-value: 3.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  47 EVSALLhYVPD------LRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFVqlaTLKQRTEkaartagrmpagqqth 120
Cdd:cd00798    3 EVERLL-DAPDtdtplgLRDRAILELLYASGLRVSELVGLDLSDVDLDEGLVRV---TGKGNKE---------------- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 121 RLVPLSDSwYVSQLQT--MVATLKIPMERR------NKRTGRTEKARIWEVTDRTVRTwigeavaaaaadgVTFSVPVTP 192
Cdd:cd00798   63 RLVPFGSY-AVEALEEylEERRPLLLKKKPpdalflNKRGKRLSRRGVWRILKKYAER-------------AGLPKHVSP 128

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 510918145 193 HTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:cd00798  129 HTLRHSFATHLLEGGADLRVVQELLGHASLSTTQIYTHV 167
INT_RitC_C_like cd01182
C-terminal catalytic domain of recombinase RitC, a component of the recombinase trio; ...
 43-231 8.09e-18

C-terminal catalytic domain of recombinase RitC, a component of the recombinase trio; Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.


Pssm-ID: 271183 [Multi-domain]  Cd Length: 186  Bit Score: 78.47  E-value: 8.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  43 LLAPEVSALLHyVPDL------RRKMLLATLWNTGARINEALALTRGDFSLTPPyPFVQLaTLKQRTEkaartagrmpag 116
Cdd:cd01182    1 LTREEMKALLA-APDRntslgrRDHALLLLLYDTGARVQELADLTIRDLRLDDP-ATVRL-HGKGRKE------------ 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 117 qqthRLVPLSDSW------YVSQLQ-TMVATLKIPMeRRNKRTGRTEKARIwevtDRTVRTWIGEAVAAAAadgvTFSVP 189
Cdd:cd01182   66 ----RTVPLWKETvaalkaYLQEFHlTPDPKQLFPL-FPNRRGQPLTRDGV----AYILNKYVALASNRCP----SLPKR 132

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 510918145 190 VTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:cd01182  133 ITPHTLRHTKAMHLLQAGVDLTVIRDWLGHESVETTQIYAEA 174
XerC COG4973
Site-specific recombinase XerC [Replication, recombination and repair];
39-231 5.68e-16

Site-specific recombinase XerC [Replication, recombination and repair];


Pssm-ID: 443998 [Multi-domain]  Cd Length: 287  Bit Score: 75.38  E-value: 5.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  39 LPKYLLAPEVSALLHYVPD----LRRKMLLATLWNTGARINEALALTRGDFSLTPPYpfvqlATLKQRTEKaartagrmp 114
Cdd:COG4973  108 LPRALTVDELAQLLDALADdplaVRDRAIVELLYSTGLRLGELVGLDWEDVDLDAGE-----VRVRGKTGK--------- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 115 agqqtHRLVPLSDSwyvsqlqtMVATLKIPMERRNKRTGRTEKA-----RIWEVTDRTVRTWIGEAVAAAaadGVtfSVP 189
Cdd:COG4973  174 -----SRTVPLGPK--------ALAALREWLAVRPELAAPDEGAlfpsrRGTRLSPRNVQKRLRRLAKKA---GL--PKH 235

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 510918145 190 VTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:COG4973  236 VHPHDLRHSFATHLLESGGDLRAVQELLGHASISTTQIYTHL 277
xerC PRK00236
site-specific tyrosine recombinase XerC; Reviewed
 39-231 1.05e-13

site-specific tyrosine recombinase XerC; Reviewed


Pssm-ID: 234698 [Multi-domain]  Cd Length: 297  Bit Score: 69.41  E-value: 1.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  39 LPKYLLAPEVSALLHYVPD-----LRRKMLLATLWNTGARINEALALTRGDFSLtppypfvQLATL-------KQRTeka 106
Cdd:PRK00236 112 LPKPLDVDQAKRLLDAIDEddplaLRDRAILELLYGSGLRLSELVGLDIDDLDL-------ASGTLrvlgkgnKERT--- 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 107 artagrmpagqqthrlVPLSDswYVSQ-LQTMVATLKIPMER-----RNKRTGRTEKARIwevtDRTVRTWIGEAvaaaa 180
Cdd:PRK00236 182 ----------------VPLGR--AAREaLEAYLALRPLFLPDddalfLGARGGRLSPRVV----QRRVKKLGKKA----- 234

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 510918145 181 adGVTFSVpvTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:PRK00236 235 --GLPSHI--TPHKLRHSFATHLLESGGDLRAVQELLGHASLSTTQIYTHV 281
INT_Rci_Hp1_C cd00796
Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal ...
 41-229 1.06e-13

Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain; Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271177 [Multi-domain]  Cd Length: 162  Bit Score: 66.97  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  41 KYLLAPEVSALLHYVPDLRRKMLLATLW---NTGARINEALALTRGDFSLtpPYPFVQLATLKQRTekaartagrmpagq 117
Cdd:cd00796    3 RFLTEDEEARLLAALEESTNPHLRLIVLlalYTGARRGEILSLRWDDIDL--EVGLIVLPETKNGK-------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 118 qtHRLVPLSDSWYvSQLQTMvatlkipmERRNKRTGRTEKARIWEVTDRTVRTWIGEAVAAAAADGVTFsvpvtpHTFRH 197
Cdd:cd00796   67 --PRTVPLSDEAI-AILKEL--------KRKRGKDGFFVDGRFFGIPIASLRRAFKKARKRAGLEDLRF------HDLRH 129

                        170       180       190
                 ....*....|....*....|....*....|..
gi 510918145 198 SYAMHMLYAGIPLKVLQSLMGHKSISSTEVYT 229
Cdd:cd00796  130 TFASRLVQAGVPIKTVAKILGHSSIKMTMRYA 161
INT_ICEBs1_C_like cd01189
C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons; ...
 47-230 3.53e-13

C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons; This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271189 [Multi-domain]  Cd Length: 147  Bit Score: 65.27  E-value: 3.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  47 EVSALLHYVP--DLRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFVQlATLKQRTEKAARTAGrmPAGQQTHRLVP 124
Cdd:cd01189    3 ELKKLLEALKkrGDRYYLLFLLALLTGLRRGELLALTWSDIDFENGTIRIN-RTLVRKKKGGYVIKP--PKTKSSIRTIP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 125 LSDsWYVSQLQTMVATLKIpMERRNKRtgrtekariwevtdrtvrtwigeavaaaaadgvtfsvPVTPHTFRHSYAMHML 204
Cdd:cd01189   80 LPD-ELIELLKELKAFKKL-LKKAGLP-------------------------------------RITPHDLRHTFASLLL 120

                        170       180
                 ....*....|....*....|....*..
gi 510918145 205 YAGIPLKVLQSLMGHKSISST-EVYTK 230
Cdd:cd01189  121 EAGVPLKVIAERLGHSDISTTlDVYAH 147
xerD PRK00283
tyrosine recombinase;
39-243 1.38e-12

tyrosine recombinase;


Pssm-ID: 234713 [Multi-domain]  Cd Length: 299  Bit Score: 65.98  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  39 LPKYLLAPEVSALLHYVP-----DLRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFVqlaTLKQRTEkaartagrm 113
Cdd:PRK00283 110 LPKTLSEAQVEALLDAPDidtplGLRDRAMLELLYATGLRVSELVGLTLDDVSLRQGVVRV---TGKGNKE--------- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 114 pagqqthRLVPLS-------DSWYVSQLQTMVATLKIPMERRNKRTGRTEKARIW-EVTDRTVRTWIGeavaaaaadgvt 185
Cdd:PRK00283 178 -------RLVPLGeeavyaiERYLERGRPALLNGRSSDALFPSARGGQLTRQTFWhRIKHYAKRAGID------------ 238

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 510918145 186 fSVPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVfaldvaARHRVQ 243
Cdd:PRK00283 239 -PKKLSPHVLRHAFATHLLNHGADLRVVQELLGHSDISTTQIYTHV------ATERLK 289
INTN1_C_like cd01185
Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal ...
 189-232 7.70e-12

Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain; IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271185 [Multi-domain]  Cd Length: 161  Bit Score: 61.90  E-value: 7.70e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 510918145 189 PVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVF 232
Cdd:cd01185  114 HLTFHVARHTFATLLLLKGVDIETISKLLGHSSIKTTQIYAKIV 157
integrase_gron TIGR02249
integron integrase; Members of this family are integrases associated with integrons (and ...
 189-231 1.55e-10

integron integrase; Members of this family are integrases associated with integrons (and super-integrons), which are systems for incorporating and expressing cassettes of laterally transferred DNA. Incorporation occurs at an attI site. A super-integron, as in Vibrio sp., may include over 100 cassettes. This family belongs to the phage integrase family (pfam00589) that also includes recombinases XerC (TIGR02224) and XerD (TIGR02225), which are bacterial housekeeping proteins. Within this family of integron integrases, some are designated by class, e.g. IntI4, a class 4 integron integrase from Vibrio cholerae N16961. [DNA metabolism, DNA replication, recombination, and repair, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 131303 [Multi-domain]  Cd Length: 315  Bit Score: 60.10  E-value: 1.55e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 510918145  189 PVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:TIGR02249 258 PVTCHTLRHSFATHLLESGADIRTVQELLGHSDVKTTQIYTHV 300
INT_tnpA_C_Tn554 cd01186
Putative Transposase A from transposon Tn554, C-terminal catalytic domain; This family ...
 43-225 8.91e-10

Putative Transposase A from transposon Tn554, C-terminal catalytic domain; This family includes putative Transposase A from transposon Tn554. It belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271186 [Multi-domain]  Cd Length: 184  Bit Score: 56.66  E-value: 8.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  43 LLAPEVSALLHYVPDLRRKMLLATLWNTGARINEALALTRGDFSLTPPYpfvqlATLKQRTEKAarTAGRmpAGQQTHRL 122
Cdd:cd01186    2 LTPREVQELINACNNLRDKFLLALLYETGLRIGEALGLRIEDIDMADNQ-----IELVPREDNT--NEAR--AKSMRERR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 123 VPLSDSwyvsqLQTMVATLKIPMERRNKRTGRTEKARIWE------VTDRTVRTWIGEAVAAAAADgvtfsvpVTPHTFR 196
Cdd:cd01186   73 IPVSQD-----LIDLYADYLTYIYCEEAEFSITVFVNVKGgnqgkaMNYSDVYDLVRRLKKRTGID-------FTPHMFR 140

                        170       180
                 ....*....|....*....|....*....
gi 510918145 197 HSYAMHMLYAGIPLKVLQSLMGHKSISST 225
Cdd:cd01186  141 HTHATALIRAGWSIEVVARRLGHAHVQTT 169
INT_RitA_C_like cd01188
C-terminal catalytic domain of recombinase RitA, a component of the recombinase trio; ...
 192-231 8.72e-08

C-terminal catalytic domain of recombinase RitA, a component of the recombinase trio; Recombinases RitA (also known as pAE1), RitB, and RitC are encoded by three adjacent and overlapping genes. Collectively they are known as the Recombinase in Trio (RIT). This RitA family includes various bacterial integrases and integrases from the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus H1. All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271188 [Multi-domain]  Cd Length: 179  Bit Score: 50.70  E-value: 8.72e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 510918145 192 PHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:cd01188  130 THSLRHSLATRMLRAGTSLKVIADLLGHRSIETTAIYAKI 169
xerC PRK01287
site-specific tyrosine recombinase XerC; Reviewed
 193-231 2.00e-07

site-specific tyrosine recombinase XerC; Reviewed


Pssm-ID: 234935 [Multi-domain]  Cd Length: 358  Bit Score: 51.29  E-value: 2.00e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 510918145 193 HTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:PRK01287 268 HLFRHAMATQMLENGADTRHIQAILGHAKLETTQIYTRV 306
PRK15417 PRK15417
integron integrase;
189-234 1.25e-06

integron integrase;


Pssm-ID: 185315 [Multi-domain]  Cd Length: 337  Bit Score: 48.89  E-value: 1.25e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 510918145 189 PVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVFAL 234
Cdd:PRK15417 273 PATPHTLRHSFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKV 318
xerS PRK05084
site-specific tyrosine recombinase XerS; Reviewed
 186-231 1.42e-05

site-specific tyrosine recombinase XerS; Reviewed


Pssm-ID: 235339 [Multi-domain]  Cd Length: 357  Bit Score: 45.68  E-value: 1.42e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 510918145 186 FSVPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKV 231
Cdd:PRK05084 299 FGVRLTPHKLRHTLATRLYDATKDQVLVADQLGHTSTETTDLYTHI 344
INT_C_like_1 cd01184
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ...
 70-230 1.82e-05

Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain containing six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271184 [Multi-domain]  Cd Length: 180  Bit Score: 44.22  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  70 TGARINEALALTRGD---------FSLTPPYPFVQLATlkqrteKAARtagrmpagqqthRLVPLSDSWYVSQLQTMVAT 140
Cdd:cd01184   35 TGARLNEICQLRVDDikeedgiwcIDINDDAEGRRLKT------KASR------------RLVPIHPRLIELGFLDYVEA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 141 LK-IPMERRNKRTGRTEKARIWEVTD---RTVRTWIGeavaaAAADGVTFsvpvtpHTFRHSYAMHMLYAGIPLKVLQSL 216
Cdd:cd01184   97 LRaDGKLFLFPEKRDKDGKYSKAASKwfnRLLRKLGI-----KDDERKSF------HSFRHTFITALKRAGVPEELIAQI 165

                        170
                 ....*....|....*
gi 510918145 217 MGHK-SISSTEVYTK 230
Cdd:cd01184  166 VGHSrGGVTHDTYGK 180
recomb_GmtY NF040693
gamma-mobile-trio recombinase GmtY; GmtY (gamma-mobile-trio system tyrosine recombinase) is a ...
 191-238 2.86e-05

gamma-mobile-trio recombinase GmtY; GmtY (gamma-mobile-trio system tyrosine recombinase) is a putative integrase regularly found associated with two other proteins of unknown function, in a cassette found sporadically in various Gamma-proteobacteria. Members of this family include VPA1270, found in pathogenicity island 6 of Vibrio parahaemolyticus RIMD2210633.


Pssm-ID: 468657 [Multi-domain]  Cd Length: 441  Bit Score: 44.91  E-value: 2.86e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 510918145 191 TPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVFALDVAA 238
Cdd:NF040693 392 TPHGHRHAYGRRLRNAGVDPLEIQKAMHHKSPESQLVYTQPTAAEVRA 439
INT_C_like_2 cd01191
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ...
 190-228 1.32e-04

Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271191  Cd Length: 176  Bit Score: 41.64  E-value: 1.32e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 510918145 190 VTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVY 228
Cdd:cd01191  120 VYPHSFRHRFAKNFLEKYNDIALLADLMGHESIETTRIY 158
FimB COG0582
Integrase/recombinase, includes phage integrase [Replication, recombination and repair, ...
 37-235 1.09e-03

Integrase/recombinase, includes phage integrase [Replication, recombination and repair, Mobilome: prophages, transposons];


Pssm-ID: 440347 [Multi-domain]  Cd Length: 391  Bit Score: 39.64  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145  37 DELPKyLLApevsALLHYVPDLRRKMLLATLWNTGARINEALALTRGDFSLtppypfvqlatlkqrtEKA--ARTAGRMP 114
Cdd:COG0582  209 EELPE-LLR----ALDAYRGSPVTRLALRLLLLTGVRPGELRGARWSEIDL----------------EAAlwTIPAERMK 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 115 AGQQthRLVPLSDswyvsQLQTMVATLKiPMERRNKR--TGRTEKARIweVTDRTVRTWIGEAvaaaaadGVTfsvPVTP 192
Cdd:COG0582  268 TRRP--HIVPLSR-----QALEILKELK-PLTGDSEYvfPSRRGPKKP--MSENTLNKALRRM-------GYG---RFTP 327

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 510918145 193 HTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTE-VYTKVFALD 235
Cdd:COG0582  328 HGFRHTASTLLNEAGFPPDVIERQLAHKDGNKVRaAYNRADYLE 371
INT_tnpB_C_Tn554 cd01187
Putative Transposase B from transposon Tn554, C-terminal catalytic domain; This family ...
 150-228 3.79e-03

Putative Transposase B from transposon Tn554, C-terminal catalytic domain; This family includes putative Transposase B from transposon Tn554. It belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain containing six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271187 [Multi-domain]  Cd Length: 142  Bit Score: 36.64  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510918145 150 KRTGRTEKARIWEVTDRTVRTWIGE----AVAAAAADGVTFSVPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISST 225
Cdd:cd01187   58 NKGGKQLDIPISKKVAELIKTINWTlnelSELKNISDDHGERFRFHTHRFRHTVATRLANSGMGILVLQQLLGHSSPEMT 137


                 ...
gi 510918145 226 EVY 228
Cdd:cd01187  138 LRY 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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