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Conserved domains on  [gi|510836554|ref|WP_016208173|]
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amino acid ABC transporter permease [Clostridium sartagoforme]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 12-224 7.00e-57

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 179.50  E-value: 7.00e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  12 FDNGKRLIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPtLLDVHLDS 91
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLP-LLGIDLSP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  92 VIVGYIVFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIG 171
Cdd:COG0765   88 FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIG 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 510836554 172 TVDLVKVGQQIIERTvltepMASFWIYGLLLIIYFLICFPISLGAKALEKKLN 224
Cdd:COG0765  168 VPELTRAAQQIASRT-----FRPFEVYLVAALIYLVLTLPLSLLARRLERRLA 215
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 12-224 7.00e-57

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 179.50  E-value: 7.00e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  12 FDNGKRLIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPtLLDVHLDS 91
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLP-LLGIDLSP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  92 VIVGYIVFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIG 171
Cdd:COG0765   88 FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIG 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 510836554 172 TVDLVKVGQQIIERTvltepMASFWIYGLLLIIYFLICFPISLGAKALEKKLN 224
Cdd:COG0765  168 VPELTRAAQQIASRT-----FRPFEVYLVAALIYLVLTLPLSLLARRLERRLA 215
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 18-223 2.99e-25

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 98.20  E-value: 2.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLL-DVHLDSVIVGY 96
Cdd:PRK09494  15 LLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFnDLRIDPFTAAV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  97 IVFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIGTVDLV 176
Cdd:PRK09494  95 VTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELT 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 510836554 177 KVGQQIIERTvltepMASFWIYGLLLIIYFLICFPISLGAKALEKKL 223
Cdd:PRK09494 175 RQGQEIIAGN-----FRALEIWSAVAVIYLIITLVLSFILRRLERRM 216
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 18-204 1.89e-18

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 80.28  E-value: 1.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554   18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLlDVHLDSVIVGYI 97
Cdd:TIGR03003  13 LIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDI-GIRLPALVAGVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554   98 VFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIGTVDLVK 177
Cdd:TIGR03003  92 GLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMN 171

                         170       180
                  ....*....|....*....|....*...
gi 510836554  178 VGQQIIERTV-LTEPMASFWIYGLLLII 204
Cdd:TIGR03003 172 QAKSIGNSTFrYLEPMTLVGVFFLILSI 199
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 22-208 2.70e-12

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 63.07  E-value: 2.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  22 LLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFY--FGVPTLLDVHLDSVIVGYIVF 99
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVllFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554 100 TLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIGTVDLVKVG 179
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|....*....
gi 510836554 180 QQIIerTVLTEPMASFWIYGLLLIIYFLI 208
Cdd:cd06261  161 TGLL--LIFAILFPGDLGVAAAVALILLL 187
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 40-223 7.37e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 41.90  E-value: 7.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554   40 GIIFGIVM-TSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLLDVHLD-SVIVGYIVFTLWGTAEIgdlVRGAITS 117
Cdd:pfam00528   1 GIPLGIIAaLRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGIlPAIILALLGWAGYARLI---RRAALRS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  118 IPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIGTvdLVKVGQQIIERTVLTEPMASFWI 197
Cdd:pfam00528  78 LPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGS--WPGLGLLLIEAILGYDYPEIQGP 155

                         170       180
                  ....*....|....*....|....*.
gi 510836554  198 YGLLLIIYFLICFPISLGAKALEKKL 223
Cdd:pfam00528 156 VLAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 12-224 7.00e-57

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 179.50  E-value: 7.00e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  12 FDNGKRLIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPtLLDVHLDS 91
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLP-LLGIDLSP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  92 VIVGYIVFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIG 171
Cdd:COG0765   88 FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIG 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 510836554 172 TVDLVKVGQQIIERTvltepMASFWIYGLLLIIYFLICFPISLGAKALEKKLN 224
Cdd:COG0765  168 VPELTRAAQQIASRT-----FRPFEVYLVAALIYLVLTLPLSLLARRLERRLA 215
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
15-224 1.49e-25

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 99.43  E-value: 1.49e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  15 GKRLIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLL--------- 85
Cdd:COG4215   15 GPALLAGALVTLELALLSLLLGLVLGLLGALAKLSGNRPLRWLATGYTTVVRGVPDLLLILLLYFGGQILLnaladlfgy 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  86 --DVHLDSVIVGYIVFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKT 163
Cdd:COG4215   95 dgFIEINPFVAGVLALGFVFGAYATEVFRGAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPGLGNNWLVLLKD 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 510836554 164 TTLMTLIGTVDLVKVGQQIIERTvlTEPmasFWIYGLLLIIYFLICFPISLGAKALEKKLN 224
Cdd:COG4215  175 TALVSVIGLVDLVRQAQEAAGST--REP---FTFYLAAALIYLALTTVSELVLARLERRAS 230
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 18-223 2.99e-25

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 98.20  E-value: 2.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLL-DVHLDSVIVGY 96
Cdd:PRK09494  15 LLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFnDLRIDPFTAAV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  97 IVFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIGTVDLV 176
Cdd:PRK09494  95 VTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELT 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 510836554 177 KVGQQIIERTvltepMASFWIYGLLLIIYFLICFPISLGAKALEKKL 223
Cdd:PRK09494 175 RQGQEIIAGN-----FRALEIWSAVAVIYLIITLVLSFILRRLERRM 216
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 18-204 1.89e-18

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 80.28  E-value: 1.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554   18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLlDVHLDSVIVGYI 97
Cdd:TIGR03003  13 LIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDI-GIRLPALVAGVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554   98 VFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIGTVDLVK 177
Cdd:TIGR03003  92 GLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMN 171

                         170       180
                  ....*....|....*....|....*...
gi 510836554  178 VGQQIIERTV-LTEPMASFWIYGLLLII 204
Cdd:TIGR03003 172 QAKSIGNSTFrYLEPMTLVGVFFLILSI 199
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
18-208 4.19e-18

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 79.72  E-value: 4.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIP-IMVWLFIfYFGVPTLLDVHLDSVIVGY 96
Cdd:PRK11123   7 LASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPeILVVLFI-YFGSSQLLLTLSDGFTLNL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  97 IVFTLWGTAEIGDL-----------------------VRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGI 153
Cdd:PRK11123  86 GFVQIPVQMDIENFevspflcgvialsllyaayasqtLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGL 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 510836554 154 INLSTRMIKTTTLMTLIGTVDLVKVGQQIIERTvlTEPmasFWIYGLLLIIYFLI 208
Cdd:PRK11123 166 GNQWLVLLKDTALVSLISVNDLMLQTKSIATRT--QEP---FTWYIIAAAIYLVI 215
PRK15069 PRK15069
histidine ABC transporter permease HisM;
10-210 6.72e-15

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 70.85  E-value: 6.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  10 FNFDNGKRLiEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLLDVHL 89
Cdd:PRK15069  12 LLWTDGYRF-TGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSLEIVRG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  90 DSVIVGY---------IVFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRM 160
Cdd:PRK15069  91 TDLLDAFfrsglnctiLAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILM 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 510836554 161 IKTTTLMTLIGTVDLVKVGQQIIERTvltepMASFWIYGLLLIIYFLICF 210
Cdd:PRK15069 171 LHATTLAFTATVPDILKIARDINSAT-----YQPFQAFGIAAVLYLIISF 215
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
18-180 1.57e-14

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 69.82  E-value: 1.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLLD----------V 87
Cdd:PRK15135   9 ILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNsvtealgvgqI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  88 HLDSVIVGYIVFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLM 167
Cdd:PRK15135  89 DIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALV 168

                        170
                 ....*....|...
gi 510836554 168 TLIGTVDLVKVGQ 180
Cdd:PRK15135 169 SLLGLEDVVKATQ 181
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 18-113 1.45e-13

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 64.09  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554   18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTlLDVHLDSVIVGYI 97
Cdd:TIGR01726   5 LLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPL-IGIRLSPLTAAVI 83

                          90
                  ....*....|....*.
gi 510836554   98 VFTLWGTAEIGDLVRG 113
Cdd:TIGR01726  84 ALTLFYGAYLAEIFRG 99
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 22-208 2.70e-12

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 63.07  E-value: 2.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  22 LLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFY--FGVPTLLDVHLDSVIVGYIVF 99
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVllFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554 100 TLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIGTVDLVKVG 179
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|....*....
gi 510836554 180 QQIIerTVLTEPMASFWIYGLLLIIYFLI 208
Cdd:cd06261  161 TGLL--LIFAILFPGDLGVAAAVALILLL 187
artM PRK11122
arginine ABC transporter permease ArtM;
18-222 6.05e-12

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 62.67  E-value: 6.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFG---------VPTLLDVH 88
Cdd:PRK11122   8 LLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqfpwlqeYPWLWHLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  89 LDSVIVGYIVFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRyIIIPISIRRVLPGIINLSTRMIKTTTLMT 168
Cdd:PRK11122  88 SQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFKSTSLAY 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 510836554 169 LIGTVDLVKVGQQIIERTVLTEpmasfwIYGLLLIIYFLICFPISLGAKALEKK 222
Cdd:PRK11122 167 TITLMDVMGYSQLLYGRTYDVM------VFGAAGIIYLVVNGLLTLLMRLIERK 214
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
18-222 6.34e-12

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 62.54  E-value: 6.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLL----------DV 87
Cdd:PRK15107  16 LLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLqnvlglspktDI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  88 HLDSVIVGyivFTLWGTAEIGDLVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLM 167
Cdd:PRK15107  96 RLISAMVA---FSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLV 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 510836554 168 TLIGTVDLVKVGQQIIERTVLTEPMASFwiyglLLIIYFLICFPISLGAKALEKK 222
Cdd:PRK15107 173 YVLSLADFFRTASTIGERDGTQVEMILF-----AGFVYFVISLSASLLVSYLKKR 222
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 18-153 3.92e-05

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 43.21  E-value: 3.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  18 LIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSkKKIVKIICNIYLESIRIIPIMVW--LFIFYFGVPTLLDVhldsVIVG 95
Cdd:COG0600   59 LWEHLLASLLRVLLGFALAALLGVPLGLLLGL-SRLLRRLLDPLLVFLRPIPPLALapLLILWFGIGEASKI----FVIF 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  96 YIVF--TLWGTAEigdlvrgAITSIPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGI 153
Cdd:COG0600  134 LGAFfpILLNTAA-------GVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGL 186
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 40-223 7.37e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 41.90  E-value: 7.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554   40 GIIFGIVM-TSKKKIVKIICNIYLESIRIIPIMVWLFIFYFGVPTLLDVHLD-SVIVGYIVFTLWGTAEIgdlVRGAITS 117
Cdd:pfam00528   1 GIPLGIIAaLRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGIlPAIILALLGWAGYARLI---RRAALRS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  118 IPKIYYESSMALSLNKAKTYRYIIIPISIRRVLPGIINLSTRMIKTTTLMTLIGTvdLVKVGQQIIERTVLTEPMASFWI 197
Cdd:pfam00528  78 LPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGS--WPGLGLLLIEAILGYDYPEIQGP 155

                         170       180
                  ....*....|....*....|....*.
gi 510836554  198 YGLLLIIYFLICFPISLGAKALEKKL 223
Cdd:pfam00528 156 VLAAALILLLLNLLVDILQRLLDPRV 181
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 11-80 1.85e-04

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 41.22  E-value: 1.85e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 510836554  11 NFDNGKRLIEGLLVTLNIAVVSVVLSTILGIIFGIVM---TSKKKIVKIICNIYLESIRIIPIMVW--LFIFYFG 80
Cdd:COG3639   42 DWSYLPDLLSALLETLAIALLGTLLGAVLALPLAFLAarnLAPNPWVRLLARRLLNVLRAIPELVWalIFVAAVG 116
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 17-154 2.38e-03

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 38.17  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510836554  17 RLIEGLLVTLNIAVVSVVLSTILGIIFGIVMTSKKKIVKIICNIYLESIRIIPIMVW---LFIFYFGVPtlLDVHLDSVI 93
Cdd:COG1177   58 RLLDALLNSLLIALLSTLLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLgvaLLLLFSALG--LSGGLWGLI 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 510836554  94 VGYIVFTLWGTAEIgdlVRGAITSIPKIYYESSMALSLNKAKTYRYIIIPIsirrVLPGII 154
Cdd:COG1177  136 LAHVVFTLPFVVLV---VLARLQGFDPSLEEAARDLGASPWQTFRRVTLPL----IAPGIL 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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