|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
2-849 |
0e+00 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 1534.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 2 GKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSATKKSADststktakkpkkderGALVNRMGVDPWHNWDA 81
Cdd:PRK07561 1 GKSLVIVESPAKAKTINKYLGSDYVVKASVGHIRDLPTSASSVPAKEK---------------GALWARMGVDPDHDFEA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 82 RYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTRYSRVVFNEITKNAIRQAFEKPGELNIDR 161
Cdd:PRK07561 66 LYEVLPGKEKVVSELKKAAKDADELYLATDPDREGEAIAWHLLEVLGGDDVPVKRVVFNEITKNAIQEAFENPRELDINL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 162 VNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPGGDALPLEVTHQ 241
Cdd:PRK07561 146 VNAQQARRFLDRLVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTPRGDAFEARLTHL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 242 NDKPFRPV---NREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT 318
Cdd:PRK07561 226 DGKKFAPVdllNEAQAEAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYIT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 319 YMRTDSTNLSQDAVNMVRDYISDNFGKKYLPESANQYASK-ENSQEAHEAIRPSDVAVQAESLKDMEADAQKLYQLIWRQ 397
Cdd:PRK07561 306 YMRTDSTNLSQEAINAARGYIGDNYGKKYLPEKPRQYSSKaKNAQEAHEAIRPSDVFRTPDQLKGLEGDAQRLYELIWKR 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG---DEDRILPAVDKGDTLTLIELTPAQHFTKPP 474
Cdd:PRK07561 386 FVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRDDaldDEDRRLPALKVGDALTLEKLDPTQHFTKPP 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 475 ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVA 554
Cdd:PRK07561 466 ARYSEASLVKELEKLGIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRLEEFFPRLVDYDFTARMEEELDDIA 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 555 NHEAEWKGVLDNFFTDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALspKERCKTTI 634
Cdd:PRK07561 546 NGEADWKPVLDDFYKDFSQQLEKAEELREEGGMRPNQMVITDRDCPTCGRGMGIRTGKTGVFLGCSGYAL--KERCKTTR 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 635 NLVPENEVLNVLEGDDAETNALRAKrrcQKCGTAM-------DSYLI----DPKRKLHVC-GNNPTCDGYEIEEGEFRIK 702
Cdd:PRK07561 624 NLTPEEETLNVLEGEDAETRALGAD---PECGTAMvlrsgrfGPYVQegegDKPRRLSLPkGNNPECVGLEIALGLLSLP 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 703 gydGPIVECEKCGSEMHLKMGRFGKYMAC--TNDECKNTRKILRNGEVAP---------PKEDPVPLPELPCEKSDAYFV 771
Cdd:PRK07561 701 ---RPVGEHPECGSEIQAKIGRFGPYVKCggTYASLKNTRKVLTIGLNRAvellaepkrPKEDPVPLPELGCPKSGAPFV 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 772 LRDGAAGIFL----AANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQTDPDGNKSMVRFSRKTKQQYVAAEKDGK 847
Cdd:PRK07561 778 LRDGRYGPYVkhgkANATLPKGRETRAPTVEEALELLAEKPEKLRYLADAPAKDPAGKKAAVKFSRKTKQQYVASEKDGK 857
|
..
gi 507082503 848 AT 849
Cdd:PRK07561 858 AT 859
|
|
| topA_bact |
TIGR01051 |
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of ... |
5-637 |
0e+00 |
|
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273416 [Multi-domain] Cd Length: 610 Bit Score: 929.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 5 LVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSgsatkksadststktakkpkkdergalvnRMGVDPWHNWDARYE 84
Cdd:TIGR01051 1 LVIVESPAKAKTIKKYLGDEYEVEASMGHIRDLPKS-----------------------------RLGVDIEKDFEPEYV 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 85 VLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTRYSRVVFNEITKNAIRQAFEKPGELNIDRVNA 164
Cdd:TIGR01051 52 VSKGKKKVVKELKTLAKKADEVYLATDPDREGEAIAWHLAEVLKPKDPVYKRIVFNEITKKAIRAALKNPREIDMNLVNA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 165 QQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDAnTTTPGGDALPLEVTHQNDK 244
Cdd:TIGR01051 132 QQARRILDRLVGYTLSPLLWKKVAKGLSAGRVQSVALRLIVDREREIKRFVPEEYWTIDA-TFQKGEETFEALLTEVNGK 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 245 PFRPV---NREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA------- 314
Cdd:TIGR01051 211 KLKAGsdlDEAEATALKEQLKGEELVVEEIEKKPKKSRPPPPFTTSTLQQEASRKLGFSAKKTMMIAQRLYEGvstgdgt 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 315 -GYITYMRTDSTNLSQDAVNMVRDYISDNFGKKYLPESANQYASKE-NSQEAHEAIRPSDVAVQAESLKD-MEADAQKLY 391
Cdd:TIGR01051 291 iGLITYMRTDSTRLSNQAVNEARNLIDKNYGKEYLGPKPKRYKSKEkNAQEAHEAIRPTSVFRTPEELKDyLKRDEFRLY 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 392 QLIWRQFVACQMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVMPALRKG---DEDRILPAVDKGDTLTLIELTP 466
Cdd:TIGR01051 371 ELIWKRFVASQMADARYDSTSVRLTNedGEYVFKATGRKLIFDGYYKVYVEGSDDpleEKDRILPPLKEGDAVKLVEVKP 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546
Cdd:TIGR01051 451 NQHFTQPPARYTEASLVKELEELGIGRPSTYASIISTIQDRGYVKKENKRLYPTELGFAVTDLLEKHFGDVVDYDFTAKM 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 547 EDSLDQVANHEAEWKGVLDNFFTDFTQQLDKAEKdpeeggMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYalsp 626
Cdd:TIGR01051 531 EKDLDEIAEGKAEWKPVLKNFYTGFSSKVKKLRN------MRIIVDFKTSQDCPLCGRPMVVKLGKYGPFLACSNF---- 600
|
650
....*....|.
gi 507082503 627 kERCKTTINLV 637
Cdd:TIGR01051 601 -PECKYTKSIV 610
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-742 |
0e+00 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 886.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPtsgsatkksadststktAKKpkkdergalvnrMGVDPWHNWD 80
Cdd:PRK06599 1 MAKKLVIVESPAKAKTIKKYLGKDYKVLASFGHVRDLP-----------------KKK------------GGVDPDNDFA 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 81 ARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG---GDDTRYSRVVFNEITKNAIRQAFEKPGEL 157
Cdd:PRK06599 52 PKYEIIEGKEKVVDALKKAAKKADAVYLATDPDREGEAIAWHIAEVLKeakLKDKNVKRVVFNEITKKAVQEAIENPRDI 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 158 NIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPGGDALPLE 237
Cdd:PRK06599 132 DMDLVDAQQARRALDYLVGFKLSPLLWKKVRRGLSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGEPFTAK 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 238 VTHQNDK---PFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA 314
Cdd:PRK06599 212 LVEVNGKkleKFSITNEEQAKALVKALEGQAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 315 --------GYITYMRTDSTNLSQDAVNMVRDYISDNFGKKYLPESANQYASK-ENSQEAHEAIRPSDVAVQAESLKD-ME 384
Cdd:PRK06599 292 idlgegtvGLITYMRTDSVRLSNEALDEARKYITKKYGKEYLPAKPRVYKKKsKNAQEAHEAIRPTSINRTPESLKPyLT 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 385 ADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVMPA---LRKGDEDRILPAVDKGDTL 459
Cdd:PRK06599 372 PDQFKLYELIWKRTVASQMAPAILDQTSVDIASenGKYVFRATGSVILFPGFLKVYGEskdDEEEDDEKLLPPLKEGEKL 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 460 TLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMN 539
Cdd:PRK06599 452 KLDELLPEQHFTEPPPRYSEASLVKKLEEYGIGRPSTYASIISTLQDREYVELEKKRFIPTDLGRIVNDFLVEHFPKYVD 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 540 YDFTAQMEDSLDQVANHEAEWKGVLDNFFTDFTQQLDKAEKDPEEGGMRPNQmvlTSIDCPTC-GRKMGIRTASTGVFLG 618
Cdd:PRK06599 532 YDFTAGLEDELDEIAEGKKDWKPVLREFWEPFISNLEKVEEDVRTEKVTQEE---TDETCPKCgGGPLVLKLGKNGKFLG 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 619 CSGYalsPKerCKTTINLVPENEVlnvlegddaetnalrakrrcqkcgtamdsylidpkrklhvcgnnptcdgyEIEEGE 698
Cdd:PRK06599 609 CSGY---PE--CKYTKNITRDEDE--------------------------------------------------PIEEEE 633
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 507082503 699 FRikgydgPIVECEKCGSEMHLKMGRFGKYMACTND-ECKNTRKI 742
Cdd:PRK06599 634 IV------EEEKCPKCGGPLVLKKGRYGKFLACSGYpECKHIKPL 672
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
3-576 |
0e+00 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 863.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsatkksadststktakkpkkdergalvnrMGVDPWHNWDAR 82
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLGKDYVVTASVGHLRDLPKPE-----------------------------LDVDVENDFEPK 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDDTRYSRVVFNEITKNAIRQAFEKPGELNIDRV 162
Cdd:COG0550 52 YEVIPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLG-DKKPVKRVVFNEITKKAIKEAFKNPRDIDMNLV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 163 NAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPGGdalPLEVTHQN 242
Cdd:COG0550 131 DAQQARRILDRLVGYNLSPLLWKKVKRGLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGG---EFTAKLVK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 243 DKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRT 322
Cdd:COG0550 208 IDGKKILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRT 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 323 DSTNLSQDAVNMVRDYISDNFGKKYLPESANQYASKENSQEAHEAIRPSDVAVQAESLkdmEADAQKLYQLIWRQFVACQ 402
Cdd:COG0550 288 DSVRLSEDAVAAAREYIEALYGKEYLPEKPRVYKTSKNAQEAHEAIRPTGVTRTPESL---SGDEFKLYDLIWKRFLASQ 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR---KGDEDRILPAVDKGDTLTLIELTPAQHFTKPPARFSE 479
Cdd:COG0550 365 MPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeEEEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTE 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 480 ASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHEAE 559
Cdd:COG0550 445 ASLVKAMEELGIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHFPDLVDYEFTAKMEEKLDEIAEGKLD 524
|
570
....*....|....*..
gi 507082503 560 WKGVLDNFFTDFTQQLD 576
Cdd:COG0550 525 WKDVLEEFYKPFKELVE 541
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
1-787 |
0e+00 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 609.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsatkksadststktakkpkkdergalvnrMGVDPWHNWD 80
Cdd:PRK06319 1 MKKSLIIVESPAKIKTLQKLLGEGFIFASSLGHIVDLPAKE-----------------------------FGIDIENDFE 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 81 ARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDDTRYSRVVFNEITKNAIRQAFEKPGELNID 160
Cdd:PRK06319 52 PDYQILPDKEEVINKICKLAKKCDVVYLSPDPDREGEAIAWHIANQLP-KNTKIQRISFNAITKGAVTEALKHPREIDMA 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 161 RVNAQQARRFMDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPGGDAL---- 234
Cdd:PRK06319 131 LVNAQQARRLLDRIVGYKISPILSRKLQRrsGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVHLKDPKTQKTfwah 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 235 ------------PLEVTHQNDKPFRPvNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVK 302
Cdd:PRK06319 211 lysvdgkkwekeIPEGKTEDEVLLIN-SKEKADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSS 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRDYISDNFGKKYLPESANQYASKENSQEAHEAIRPSDV 373
Cdd:PRK06319 290 RTMNIAQTLYEGvdldsegatGLITYMRTDSVRTDPEALKQVRKYIEGTFGKEFLPSSPNVYTTKKMAQDAHEAIRPTDI 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 374 AVQAESLKDMEADAQ-KLYQLIWRQFVACQMTPAKYDSTTLTVGAG-DFRLKARGRILRFDGWTKVMPALR----KGDED 447
Cdd:PRK06319 370 TLTPEKLRSKLTEDQyKLYSLIWKRFVASQMIPAIYDTLAIRITTNkGIDLRATGSLLKFKGFLAVYEEKRddegDEEEN 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 448 RILPAVDKGDTLTLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527
Cdd:PRK06319 450 IHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTLKENQRLRPTELGKIIS 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 528 DRLEENFRELMNYDFTAQMEDSLDQVANHEAEWKGVLDNFFTDFTQQLDKAEKDpeegGMRPNqmVLTSIDCPTC-GRKM 606
Cdd:PRK06319 530 QFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWELFLPVVVTAEKE----AFIPR--IVTEIDCPKChKGKL 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 607 GIRTASTGVFLGCSGYalspkerckttinlvpenevlnvlegddaetnalrakrrcqkcgtamdsylidpkrklhvcgnn 686
Cdd:PRK06319 604 VKIWAKNRYFYGCSEY---------------------------------------------------------------- 619
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 687 PTCDgYEIEEGE--FRIKGY------DGPiveCEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRNGEVAPPKEDPVP 757
Cdd:PRK06319 620 PECD-YKTSEEEltFNKEDYaedtpwDSP---CPLCGGEMKVRHGRFGTFLGCENyPECRGIINIHKKGEEGIEPEETVP 695
|
810 820 830
....*....|....*....|....*....|
gi 507082503 758 LPELPCekSDAYFVLRDGAAGIFLAANTFP 787
Cdd:PRK06319 696 CPAIGC--TGHIVKRRSRFNKMFYSCSEYP 723
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
1-616 |
0e+00 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 569.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLptsgsatkksadststktakKPKKderGAlvnrmgVDPWHNWD 80
Cdd:PRK08780 1 MSKHLVIVESPAKAKTINKYLGKDFTVLASYGHVRDL--------------------VPKE---GA------VDPENGFA 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 81 ARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG----DDTRYSRVVFNEITKNAIRQAFEKPGE 156
Cdd:PRK08780 52 MRYDLIDKNEKHVEAIAKAAKSADDLYLATDPDREGEAISWHLAEILKErgllKDKPMQRVVFTEITPRAIKEAMAKPRD 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 157 LNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPGgDALPL 236
Cdd:PRK08780 132 IASDLVDAQQARRALDYLVGFNLSPLLWRKIQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIEADCAHPS-QPFNA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 237 EVTH---QNDKPFRPVNREQTLAAVSLLEKA---RYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQR 310
Cdd:PRK08780 211 KLIKldgQKFEQFTITDGDTAEAARLRIQQAaqgTLHVTDVESKERKRNPAPPFTTSTLQQEASRKLGFTTRRTMQVAQK 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 311 LYEA---------GYITYMRTDSTNLSQDAVNMVRDYISDNFGKKYLPESANQYASK-ENSQEAHEAIRPSDVAVQAESL 380
Cdd:PRK08780 291 LYEGvdlgdegsvGLITYMRTDSVNLSQDALAEIRDVIARDYGTASLPDQPNTYKTKsKNAQEAHEAVRPTSALRTPAQV 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 381 KD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD---FRlkARGRILRFDGWTKVMPALR------KGDEDRIL 450
Cdd:PRK08780 371 ARfLSDDQRRLYELIWKRAVACQMIPATLNTVSVDLAAGSehvFR--ATGSTVVVPGFLAVYEEGKddksaeDEDEGRKL 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 451 PAVDKGDTLTLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530
Cdd:PRK08780 449 PPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKALEEYGIGRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRAVNKFL 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 531 EENFRELMNYDFTAQMEDSLDQVANHEAEWKGVLDNFFTDFTQQLDKAEK--DPEEGGmrpnQMVLTSIDcPTCGRKMGI 608
Cdd:PRK08780 529 TGHFTRYVDYDFTARLEDDLDAVSRGEKEWIPLMEKFWGPFKELVEEKKDsvDRTEAG----QVRELGTD-PKSGKPVSV 603
|
....*...
gi 507082503 609 RTASTGVF 616
Cdd:PRK08780 604 RIGRFGPM 611
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
159-575 |
3.05e-170 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 497.90 E-value: 3.05e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 159 IDRVNAQQARRFMDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDAntttpggdalpl 236
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRkgVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIKE------------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 237 evthqndkpfrpvnreqtlaavsllekarYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY 316
Cdd:cd00186 69 -----------------------------AVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGL 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 317 ITYMRTDSTNLSQDAVNMVRDYISDNFGKKYLPESANQ----YASKENSQEAHEAIRPSDVAVQAESLKDMEADAQKLYQ 392
Cdd:cd00186 120 ITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLgrrnPKRGKKEQGAHEAIRPTKVAPTPELEANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDrILPAVDKGDTLTLIELTPAQHFTK 472
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEE-EPPPLKEGDELKLEEVELEEKETQ 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQ 552
Cdd:cd00186 279 PPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410 420
....*....|....*....|...
gi 507082503 553 VANHEAEWKGVLDNFFTDFTQQL 575
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
156-565 |
2.58e-157 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 465.95 E-value: 2.58e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI--ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPGGDA 233
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLkgNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 234 lplevTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE 313
Cdd:pfam01131 81 -----ANAKWKRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 314 -AGYITYMRTDSTNLSQDA-VNMVRDYISDNFGKkYLPESANQYASK------ENSQ-EAHEAIRPSDVAVQAESLKDme 384
Cdd:pfam01131 156 kHGLITYPRTDSTYLSDDAtLKAILEYLTKNYGK-YLPYAPRLLKKTkgkltvGNAKvTAHEAIRPTGDIPVLPELSD-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 385 aDAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKgDEDRILPAVDKGDTLTLIEL 464
Cdd:pfam01131 233 -DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKK-EDEEELPELKEGEELKVTQV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLeENFRELMNYDFTA 544
Cdd:pfam01131 311 EVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEAL-EKFPDLVDPELTA 389
|
410 420
....*....|....*....|.
gi 507082503 545 QMEDSLDQVANHEAEWKGVLD 565
Cdd:pfam01131 390 ELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
272-526 |
2.13e-117 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 356.94 E-value: 2.13e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 272 EDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRDYISDNFGKKYLPES 351
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKEYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 352 A-----NQYASKENSQEAHEAIRPSDVAVQAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARG 426
Cdd:smart00437 81 VvllkpRKPRKGKKAQGAHEAIRPTKPIFTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 427 RILRFDGWTKVMPALRKgDEDRILPAVDKGDTLTLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506
Cdd:smart00437 161 KTLLFDGWLKVYPEEKK-EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239
|
250 260
....*....|....*....|
gi 507082503 507 RGYVRVENRRFYAEKMGEIV 526
Cdd:smart00437 240 RGYVTKKKKKLIPTELGIAV 259
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
5-793 |
1.97e-107 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 349.68 E-value: 1.97e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 5 LVIVESPAKAKTINKYLGNdyvvkssvghirdlptsGSATKKSADSTSTKTAKKPKKDER--GALVNRMGVD---PWHNW 79
Cdd:PRK07219 3 LIIAEKNNAARRIADILSG-----------------GKAKKKRVNGVPYYEFERKGEKWIviGLSGHIVTVDfpeEYGDW 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 80 ---------DARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI---AWHLREVIGGDDTRysRVVFNEITKNAI 147
Cdd:PRK07219 66 rdvdpaeliDADPVKKITKQNYINALKKLAKDADEIIIATDYDREGELIgkeAYHILREVCQVPVK--RARFSSLTKKEI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 148 RQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW---KKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEI 222
Cdd:PRK07219 144 RKAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSlsvRQLGRWdfLSVGRVQTPTLAFIVDREREIRAFDPEDYWKI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 223 DAN-TTTPGGDALPLEVTHQNDKPFrpvNREQTLAAVSLLEKARYS-VLEREDKPTSSKPGAPFITSTLQQAASTRLGFG 300
Cdd:PRK07219 224 EALlDKEAQYFYRDLIGGHEAEKFW---DEEEAEEIYEKLKGAKEAtVSSVKKRERTISPPAPFNTTEFLREASKIFGIS 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDaVNMvRDYISDNFGKKYLPESANQYASKEN--------SQEAHEAIRPSD 372
Cdd:PRK07219 301 PKRAMEIAEKLYTAGYISYPRTDNTVYPDD-LDP-KELLKKLSKKKEYGPYAESILEQENikptegkkETTDHPPIHPVD 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 373 VAvqaeSLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKgdEDRILPA 452
Cdd:PRK07219 379 VP----KREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKF--DEKELPD 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 453 VDKGDTLTLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVrVENRRFYAEKMGEIVTDRLEE 532
Cdd:PRK07219 453 LEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV-IEGDPPRPTDLGIAVIEALEK 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 533 NFRELMNYDFTAQMEDSLDQVANHEAEWKGVLDNFFTDFTQQLDKAEKDPEE------GGMRPNQMVLTSI-DCPTCGRK 605
Cdd:PRK07219 532 YAPEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEigdhlaGSLKAENRSLKTIgKCPECGGD 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 606 MGIRTASTGV-FLGCSGYalspkERCKTTINLvPENEVLNVLEgddaetnalrakRRCQKCGTAMDSYLIDPKRKLHVCg 684
Cdd:PRK07219 612 LIIIRTDKGSrFVGCSGY-----PDCRNTFPL-PSTGRIKVLD------------EVCEKCGLPVIKILRGKQTFVVGC- 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 685 nnPTCDGYEIEEGEFRIKGydgpivECEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRNGEVAPPKEDpvplpelpC 763
Cdd:PRK07219 673 --PDCEAEKEEEDPDEVIG------PCPKCGGELAIKQLKYGSFLGCTNyPKCKYTLPLPRRGKITVTDEK--------C 736
|
810 820 830
....*....|....*....|....*....|
gi 507082503 764 EKSDAYFVLRDGAAGIFLAANTFPKSRETR 793
Cdd:PRK07219 737 PECGLPLLRVKGGFGDELGCCNNPKCNYTE 766
|
|
| TopG2 |
COG1110 |
Reverse gyrase [Replication, recombination and repair]; |
4-568 |
5.46e-88 |
|
Reverse gyrase [Replication, recombination and repair];
Pssm-ID: 440727 [Multi-domain] Cd Length: 1219 Bit Score: 304.21 E-value: 5.46e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 4 ALVIVESPAKAKTINKYLGN-----------------DYV--VKSSVGHIRDLPTSGSA-------------------TK 45
Cdd:COG1110 631 ALVIVESPNKARTIASFFGKpsrrrigglrvyevsigDYLllITASGGHVFDLVTEAYArgfygvlvengrfipvydtIK 710
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 46 KSAD--STSTKTAKKPKKDERGALVNrmgvdpwhnwdaryevlpgKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123
Cdd:COG1110 711 RCLDcgEQFTDEVEVCPRCGSPNIVD-------------------SLEIVEALRELATEVDEVLIGTDPDTEGEKIGWDV 771
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 124 REVIGGDDTRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVR 202
Cdd:COG1110 772 YNLLRPYAKNIKRIEFHEVTRKAILEALKNPREIDENLVEAQIVRRIEDRWIGFTLSQKLWKVFGNRnLSAGRVQTPVLG 851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 203 LVVEREREikaFVPEEFWEIDAntTTPGGdalPLEVTHQNDKPFRPVNREQTLAavsllEKARYSVLEREDKPTSSKPga 282
Cdd:COG1110 852 WIIERYEE---SRKSKKYLIIL--TLENG---RLELSIEDLKEAEEVRKALEKE-----VKVKVKKVEEEEEELNPLP-- 916
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRDYISDNFGKKYLpesanqYASKENSQ 362
Cdd:COG1110 917 PYTTDTLLRDASRRLGLSAEETMRLAQDLFESGLITYHRTDSTRVSDAGIAVAKEYISERFGEEYF------KPRRWGEG 990
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 363 EAHEAIRPSDvAVQAESLKDM------------EADAQKLYQLIWRQFVACQMTPAK--YDSTTLTVGAGDFRLKARG-- 426
Cdd:COG1110 991 GAHEAIRPTR-PLDAEDLRRLieegvielpiplTRRHLRLYDLIFRRFMASQMRPAKveKVKLRVSLELPGGEIEEERiv 1069
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 427 RILRfDGWTKVMPALRKGDEdrilpaVDKGDtltlIELTPAQHFTKPPAR-FSEASLVKELEKRGIGRPSTYASIISTIQ 505
Cdd:COG1110 1070 EIIE-DGFLLIYPPIKVEPE------LKEGE----YKVTEVKIRKVPKVPlYTQGDLVREMKERGIGRPSTYAKIVETLL 1138
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507082503 506 DRGYVRVENRR--FYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHEAEWKGVLDNFF 568
Cdd:COG1110 1139 RRGYVVESKKGkkLVPTKLGIEVYNYLSENFPDLVSEERTRELEEKMDEIEEGEADYQDVLEELY 1203
|
|
| rgy |
TIGR01054 |
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial ... |
4-568 |
4.44e-85 |
|
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial thermophiles. This enzyme, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273418 [Multi-domain] Cd Length: 1171 Bit Score: 295.59 E-value: 4.44e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 4 ALVIVESPAKAKTINKYLG-----------------NDYV--VKSSVGHIRDLPTSG----------------SATKKSA 48
Cdd:TIGR01054 603 ALLVVESPNKARTIARFFGkpsvrkiggsvvyevpvGDLIlmITASGGHVFDLVTDKgfhgvlvengryvpvyTSIKRCR 682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 49 DSTSTKTAKKPKKDERGAlvnrmgvdpwhnwdaryEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG 128
Cdd:TIGR01054 683 DCGYQFTEDRESCPKCGS-----------------ENIEDSKSIIEILRELAHEVDEVFIGTDPDTEGEKIGWDLALLLS 745
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 129 GDDTRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVER 207
Cdd:TIGR01054 746 PYNPNVKRAEFHEVTRRAILEALESPRSVDENLVKAQVVRRIEDRWIGFTLSQKLWEAFNkRWLSAGRVQTPVLGWIIDR 825
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 208 EREIKAFVPEEFWEIDANtttpggdALPLEVTHQNDKPFRPVNREQTLAAVSLLEkarysvlEREDKPTsskPGAPFITS 287
Cdd:TIGR01054 826 YRESREKRGYLLIFALES-------DFRLGLEHDNRLEAKEFEKDLTWLDVEDIA-------EREEERN---PLPPYTTD 888
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRDYISDNFGKKYlpesanQYASKENSQEAHEA 367
Cdd:TIGR01054 889 TMLEDANRKLGLSVKETMQIAQELFENGLITYHRTDSTRVSDVGMRVAKEYLASRLGGEY------FYPREWGEGGAHEC 962
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 368 IRPS---DV-----AVQAESLK--DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILR-FDGWTK 436
Cdd:TIGR01054 963 IRPTrplDVddlqrLILEGVIEleGLTREHLRLYDLIFRRFMASQMRPAKVDTKEITLKADGKEAEEEGIVEIvERGFEL 1042
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 437 VMPALRKgdedrilPAVDKGDTLTLIELTPAQHFTKPParFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516
Cdd:TIGR01054 1043 VYPLWRK-------NELEKGSTFIVKDKELRSVPKVYP--YTQGEIVQEMKERGIGRPSTYATIVEKLLRRGYVVESKGF 1113
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 507082503 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHEAEWKGVLDNFF 568
Cdd:TIGR01054 1114 LIPTKLGIEVYNYLTNRYPKLVSEDRTRELEEAMDKIERGELDYLEVLESVY 1165
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
82-635 |
7.81e-79 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 268.57 E-value: 7.81e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 82 RYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAwhlREVIggDDTRY----SRVVFNEITKNAIRQAFE--KPG 155
Cdd:PRK07726 72 KLVVKKKTAKQFNVVKKLLKQATEIVIATDADREGELIA---REIL--DYCGVrkpiKRLWISSLTDKAIKRAFAnlKPG 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPG 230
Cdd:PRK07726 147 KETIPLYYSALARSRADWLVGINMTRAYTLLGRKAgyngvLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLTPGE 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 231 GdalpLEVTHQN-----DKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTM 305
Cdd:PRK07726 227 R----FTAKWQPsepyqDEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 306 MMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRDYISD-NFGKKYLPESANQYASKENSQ-------EAHEAIRPSDVAVQ 376
Cdd:PRK07726 303 DIAQSLYEtHKLITYPRTDSRYLPEDMVATLPEVLNAiSKVDPYLLLAPPVLDPSIRSRawndkkvTAHHAIIPTEQPPN 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 377 AESLKDMEadaQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE-DRILPAVDK 455
Cdd:PRK07726 383 LSKLSEDE---RKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEkEQPLPVLAK 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 456 GDTLTLIELTPAQHFTKPPARFSEASLV------------KELEKR-----GIGRPSTYASIISTIQDRGYVRVENRRFY 518
Cdd:PRK07726 460 GDELKVEKGEVKEGQTQPPKRFTEGTLLsameniarfvqdKELKKTlketdGLGTEATRAGIIEKLFKRGYLEKKGKYIH 539
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 519 AEKMGEIVTDRLEEnfrELMNYDFTAQMEDSLDQVANHEAEwkgvLDNFF---TDFTQQLdkaekdPEEGGMRPNQMVLT 595
Cdd:PRK07726 540 ATDKGKQLIDALPE---ELTSPDMTAKWEQALDQISEGQLS----YQDFMqplKQWLKQL------VEQAKQSSEKYKFD 606
|
570 580 590 600
....*....|....*....|....*....|....*....|...
gi 507082503 596 SID---CPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTIN 635
Cdd:PRK07726 607 NLTgpkCPDCGKPMLKVKGKNGKMLVCQDRECGKRKNVSKKTN 649
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
73-666 |
3.06e-77 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 266.24 E-value: 3.06e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 73 VDPWHNWDARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG--DDTRYSRVVFNEITKNAIRQA 150
Cdd:PRK07220 68 VDARDLIDAEIITTPTQKKIVTALKKLGKEADRVTIATDYDREGELIGVEALNIIKKvnPDIKFDRVRYSAITKKEIERA 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 151 FEKPGELNIDRVNAQQARRFMDRVVGYMVSPllWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDA 224
Cdd:PRK07220 148 FSNPVEVDFNLADAGHSRQVIDLVWGAALTR--YISLAAGrlgkmfLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYA 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 225 NTTTPGGdalPLEVTHQNDkpfRPVNREQTLAAVSLL-EKARYSVLEREDKptSSKPGAPFITSTLQQAASTrLGFGVKK 303
Cdd:PRK07220 226 TLENNGE---TFVAQHSTR---RFWEKEEADRVFEKLgKTAEVTEVEKGTK--TDKPPTPFNTTEFISAANS-IGFSAAN 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 304 TMMMAQRLYEAGYITYMRTDSTNL--SQDAVNMVRDYISDNFGK--KYLPESANQYASKENSQEA-HEAIRPSDVAVQAE 378
Cdd:PRK07220 297 AMRIAESLYTNGYISYPRTDNTVYpeSLDLREQIEIFAEGPFGEyaQKLLEKGELVPTRGKKETTdHPPIYPASLAKKSE 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 379 slkdMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKgdEDRILPAVDKGDT 458
Cdd:PRK07220 377 ----LKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAP--EDRLLPELSEGEE 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 459 LTLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR----VENRRFYAekmgeiVTDRLEENF 534
Cdd:PRK07220 451 LKVKKKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYIHgnpiQPTNTAFA------VVDALEKYA 524
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 535 RELMNYDFTAQMEDSLDQVANHEAEWKGVLD---NFFTDFTQQLDKAEKDPEE---GGMRPNQMVLTsidCPTCGRKMGI 608
Cdd:PRK07220 525 PTITKPDMTSRLEEDMDKIAEGKIKEDAVLEesrEMLEQVFDELDKNREKIREslrEGLREDKIIGK---CPLCGSDLMV 601
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 507082503 609 RTASTGV-FLGCSGYAlspkeRCKTTINLVPENEVLnVLEgddaetnalrakRRCQKCG 666
Cdd:PRK07220 602 RRSKRGSrFIGCEGYP-----ECTFSLPLPKSGQII-VTD------------KVCEAHG 642
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
79-622 |
1.92e-75 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 258.22 E-value: 1.92e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 79 WDARYEVLPGKE---KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDtRYSRVVFNEITKNAIRQAFEKPG 155
Cdd:TIGR01057 67 WVPIFEFDKGKGyvsKYIKALSKLAKGADEYINACDYDIEGEVIGFKALKYFCGVE-RAKRMKFSTLTKQDIRRAYANPE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTP 229
Cdd:TIGR01057 146 EIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAagrwviLSAGRVQGPTLAFLVEREREINLFVPKPYWVIKATLEKG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 230 GGdalPLEVTHQNDKPFrpvNREQtlaAVSLLEKARYS----VLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTM 305
Cdd:TIGR01057 226 GG---VFDARPEKWKIW---SEEE---AKSIKEELKKSpwaaVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQ 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 306 MMAQRLYEAGYITYMRTDSTNLSQDavnmvRDY--ISDNFGK-----------KYLPESANQYASKENsqEAHEAIRPSD 372
Cdd:TIGR01057 297 SIAQELYEEALISYPRTSSQKLPPS-----INYraILDNLAKgplyreaaerlLETGVLKPVEGKKED--PAHPAIHPTG 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 373 VAVQAESLKDMEadaqKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDriLPA 452
Cdd:TIGR01057 370 EIPSQELSKDEK----KVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEKE--LPP 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 453 VDKGDTLTLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVrVENRRFYAEKMGEIVTDRLEE 532
Cdd:TIGR01057 444 LDRGDKIKVVRVDVRVKETQPPARYDKASLIREMESRGLGTKATRARIIETLYKRGYI-EGKKSIKVTPLGEAVIETLQR 522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 533 NFRELMNYDFTAQMEDSLDQVANHEAEWKGVLDNFFTDFTQQLDKAEKDPEEGGM---RPNQMVLTSIDCPTCGRKMGIR 609
Cdd:TIGR01057 523 YCPEIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEEFKKRLDDIGIelgKSLGSVEVVGKCPKCGGKLVSK 602
|
570
....*....|...
gi 507082503 610 TASTGVFLGCSGY 622
Cdd:TIGR01057 603 YAKKGRFVGCSNY 615
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
3-622 |
2.10e-66 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 234.35 E-value: 2.10e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 3 KALVIVESPAKAKTINKYL------------GNDYVVKSSVGHIRDLPTSGSATKKSAdstSTKTAKKPkkdergalvnr 70
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLakkkkgngyleiGVGGFVTWAVGHLVELAEPEEYDEKYK---NWRTYDLP----------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 71 MGVDPWhnwdaRYEVLPGKEKVVSELKQL--AEKADHIYLATDLDREGEAIA-WHLREVIGGDDTRYSRVVFNEITKNAI 147
Cdd:TIGR01056 67 LEPEDW-----QLVVSDKTKKQFNVIKRIlkENKVDEVVIATDPDREGELIArEILDYLKVTDKVTIKRLWISSLVDSSI 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 148 RQAFEK--PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKK-----IARGLSAGRVQSVAVRLVVEREREIKAFVPEEFW 220
Cdd:TIGR01056 142 RKAFKNlrPKSETEGLYKSGVARARADWLVGINLTRAFTKLgreagNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFY 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 221 EIDANTTTPgGDALPLEVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFG 300
Cdd:TIGR01056 222 EVSATINKD-EQEFTTEWQPYKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGIS 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 301 VKKTMMMAQRLYEAG-YITYMRTDSTNLSQDAVNMVRDYIS-------DNFGKKYLPESANQYASKENSQEAHEAIRPSD 372
Cdd:TIGR01056 301 AKRTLDIAQKLYETHkLITYPRTDSRYLPEDEKEMLLEVLDalkvitpALLPIKKRDELTNNRLWNDKKIEDHHAIIPTG 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 373 VAVQAESLKDMEAdaqKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE--DRIL 450
Cdd:TIGR01056 381 NDFNLSDLSEEER---NVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEEteDTTL 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 451 PAVDKGDTLTLIELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASIISTIQDRGYVRVE 513
Cdd:TIGR01056 458 PAFQKGDELDVETLELLEKQTKPPARYTEGTLLSAMtnpaafvqdkglkktlkETKGLGTEATRADIIENLFKRGFIQKK 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 514 NRRFYAEKMGEIVTDRLEEnfrELMNYDFTAQMEDSLDQVANHEAEwkgvLDNFFTDFTQ---QLDKAEKDPEEGGMRPN 590
Cdd:TIGR01056 538 KNKIYITKNGKLLCLLLPE---LLTKPDLTAQWEQYLNGISAGEKD----DDDFINTINEmikQTINEEKKNPETIQKVA 610
|
650 660 670
....*....|....*....|....*....|..
gi 507082503 591 qmvltSIDCPTCGRKMgIRTASTGVFLGCSGY 622
Cdd:TIGR01056 611 -----KEPVSCGGIAK-CPAKDNGRLIDCKKF 636
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
1-639 |
6.70e-66 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 237.02 E-value: 6.70e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTsgsatkksadststktAKKPKKDERGALVNRMGVDPWHNWD 80
Cdd:COG1754 3 AAVLVVVVVVVVKVPAAKKVLPKYAKKKKGVKAVLKKAD----------------VAKADDKVVDDDDKKDDVDDDKKKK 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 81 ARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTRYSRVVFNEITKNAIRQAFEKPGELNID 160
Cdd:COG1754 67 KKLLKAAAKKKKALALALAADDEDEELLAADDELEEEKVIKLLLLELAVERVARAAAVRAAAAEAARLAALLRRRLVLRR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 161 RVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDAnTTTPGGDALPLEVTH 240
Cdd:COG1754 147 LVRRLLVRLLLLRLVLLLLRLLVARRAARRRRRRRRRRARRRELERRRERARAAEAEEAAAAAA-AAADAGRAAAARDGK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 241 QNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPgAPFITSTLQQAASTRLGFGVKKTMMMAQR-------LYE 313
Cdd:COG1754 226 GGGKLAAGGAAAAAAAAAAAAAAAAALAEAAAAAAVREPP-TPTTTTTAQAATTTTTRAAAARTTRSAQQaarrtrlGGE 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 314 AGYITYMRTDSTNLSQDAVNMVRDYISDNFGKKYLPESANQYASKENSQEAHEAIRPSDVAVQAESLKDMEA---DAQKL 390
Cdd:COG1754 305 GTYTTTTTTTTTTSAAAAAAAAAAAALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAAARRPPAARAALlsdDRLLL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 391 YQLIWRQFVACQMTPAKYDSTTLTV----GAGDFRLKARGRILRFDGWTKVMPALRK---GDEDRILPAVDKGDTLTLIE 463
Cdd:COG1754 385 ELLLLRRTAAAAAAAAAATATTTAAaaaaGAGAVGTAAAGAVFFFGGFLLFAEEEDDdeeDDDDDDLPALEEGLPLLKEG 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFT 543
Cdd:COG1754 465 VLADQHFTQPPPRYTEAPLVKRMEELGIGRPSTYASILSTLADRIYVRLDKRRLIPEDKGRLVTAFLFSFFRRYVEYDFT 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 544 AQMEDSLDQVANHEAEWKGVLDNFFTDFTQQLDKAEKDPEEGGMRPNQMvLTSID------CPTCGRKMGIRTASTGVFL 617
Cdd:COG1754 545 ADLEEFLDDVSDGELDWKAVLRRFWRDFSAAYDETGDLRISEVLDALED-LGEIDpreinsCPLGTGGLSLRVGRYGPFI 623
|
650 660
....*....|....*....|....*.
gi 507082503 618 GCSGY----ALSPKerCKTTINLVPE 639
Cdd:COG1754 624 ECSNYeprrASIPE--CLAPDELTPE 647
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
2-605 |
1.34e-65 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 232.19 E-value: 1.34e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 2 GKALVIVESPAKAKTIN--------------------KYLGNDYVVKSSVGHIRDLPTsgsatkksadststktakkpkk 61
Cdd:PRK05776 1 GYILVIAEKPKAARKIAealsekpircriygvpywivKRDGKKIVVAPAAGHLFGLHT---------------------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 62 DERGALVNRMgvdpwhNWDARYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDDTRYSRVV 138
Cdd:PRK05776 59 KSKGFPVFDY------EWKPLYEIDKGSkytKKYYELLSSLSKYADEFINACDYDIEGSVIGYLIIKYLG-DPKKAKRMK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 139 FNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWK--KIARG----LSAGRVQSVAVRLVVEREREIK 212
Cdd:PRK05776 132 FSALTKSDIRRAFRNLETLDYEMINAGIARHELDWLWGINVSRALMSsvRDASGkrviLSAGRVQSPTLKYVVEREIERN 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 213 AFVPEEFWEIDAnTTTPGGDALPLEVThqnDKPFRPVNREQTLAAvSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQA 292
Cdd:PRK05776 212 LFVPLPYFSVSI-IIEKNGYEFTLKYE---NKKFETKEEAKEILE-EIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVE 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDS-------------TNLSQdaVNMVRDYISDnfgkkYLPESANQYASKE 359
Cdd:PRK05776 287 AARIYGFSPYKTQSIAEDLYLDGLISYPRTNSqklpptlnirnilKGLSR--SPQYRPLVNL-----LLKETKGVLKPVQ 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 360 NSQE--AHEAIRPSdvavqAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF--RLKARGRILRFDGWT 435
Cdd:PRK05776 360 GPKDdpAHPAIYPT-----GEPPKNLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGFplVFSASGQRIEERGWL 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 436 KVMPaLRKGDEDrILPAVDKGDTLTLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515
Cdd:PRK05776 435 KYYP-FHKFDEE-ELPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGYLTSNGK 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHEAEWKGVLD---NFFTDFTQQLDKAEKD-PEEGGMRPNQ 591
Cdd:PRK05776 513 YIEVTPLGFGVAEVLEKYFPDIVSVELTRDFEEKLEMIRTGKATREEVIEeakETLNKLLEEFKKNKDEiGEELAKALGL 592
|
650
....*....|....
gi 507082503 592 MVLTSiDCPTCGRK 605
Cdd:PRK05776 593 IKPVG-KCKICGRE 605
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
64-634 |
7.54e-65 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 234.74 E-value: 7.54e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 64 RGALVNRMGVDPWHNW-----------DARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG--D 130
Cdd:PRK14973 47 RGHVVEVDFEPGYTNWrseehtprsliDADTIKKPTEKKIVGLIQKLAKKADRVTIATDFDTEGELIGKEAYELVRAvnP 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 131 DTRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG----LSAGRVQSVAVRLVVE 206
Cdd:PRK14973 127 KVPIDRARFSAITKEEIVTAFAEPTDLDFALAAAGEARQIIDLIWGASLTRFISLAAHRGgdniLSVGRVQSPTLAMIVD 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 207 REREIKAFVPEEFWEIDANTTTpggDALPLEVTHQN----DKPFRPVNREQTLAAVSLLEKARYSVLERedKPTsskpga 282
Cdd:PRK14973 207 REKEIEAFVPEKYWMLSLATEK---DGEGIEARHTHgrftDSAAAEAAYDATKEPLVVTEVKEGHKVDR--APT------ 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 283 PFITSTLQQAAStRLGFGVKKTMMMAQRLYEAGYITYMRTDST----NLSQDAV-NMVR--------DYISDNF------ 343
Cdd:PRK14973 276 PFDTTTFIVAAS-RLGFSAANAMRIAEDLYMNGYISYPRTDNTiypkSLDLNGVlATLAkgafskdvAWVKDNRrpvptr 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 344 GKKylpesanqyaskenSQEAHEAIRPSDVAVQAEsLKDmeaDAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLK 423
Cdd:PRK14973 355 GKK--------------SSTDHPPIHPTGVATREE-LGD---DRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYT 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 424 ARGRILRFDGWTKVMPALRKgdEDRILPAVDKGDTLTLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503
Cdd:PRK14973 417 ATGGRLLEAGWRTVYPYSEA--KENILPAFALGEKLPILAVNLEEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGK 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 504 IQDRGYvrVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHEAEWKGVLDNFFTDFTQQLDKAEKDPE 583
Cdd:PRK14973 495 LVSRKY--IEGNPLRPTLVGRAVTESLEEHAGTITEPDMTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAFDELEANEA 572
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 507082503 584 EGG---MRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYalsPKERCKTTI 634
Cdd:PRK14973 573 VIGrdiMERTAEELTIGPCPVCGKDLRIKHIGSSQFIGCSGY---PDCTFNIGL 623
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
3-154 |
1.35e-58 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 195.47 E-value: 1.35e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsatkksadststktakkpkkdergalvnrMGVDPWHN-WDA 81
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYLGKEYEVLASVGHIRDLPKKG-----------------------------LGVDGEDDgFEP 51
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507082503 82 RYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIgGDDTRYSRVVFNEITKNAIRQAFEKP 154
Cdd:cd03363 52 KYVVIPGKKKVVKELKKLAKKADEIYLATDPDREGEAIAWHLAEVL-KLKKNVKRVVFNEITKEAIKEALKNP 123
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
43-738 |
2.08e-52 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 195.08 E-value: 2.08e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 43 ATKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122
Cdd:COG0551 22 KKKKKKEGKKKGLAGALGLKKKLVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKKKAKALAAALAAADDDAIEAAA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 123 LREVIGGDDTRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVR 202
Cdd:COG0551 102 AADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALARLLLLAAASRALRLLLLLAAGRLRLLSAVA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 203 LVVEREREIKAFVPEEFWEIDANTTTPGGDALPLE---VTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSK 279
Cdd:COG0551 182 AGLLELEELLKEFEEEEEEEAAEEEEEEEEAKKKKeedKKKKKKKKKKDKEEETKAIKKKKKAAEAVLAAKKAAKEAKAK 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-----------TYMRTDSTNLSQDAVNMVRDYISDNFGKKYL 348
Cdd:COG0551 262 KELPTTTTDALPEALATTSLTAAAAASALAAALLEEEGellytggyiryTRTPKSSEADALAALEALKKIAEEPPDERAK 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 349 PESANQYASKENSQEAHEAIRPSDVAVQAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI 428
Cdd:COG0551 342 KKKKKAKKKKASEAKETTDHPPIPPTTAAALLELLEDRKLLLELLVRRRFAAAADLAKVEELTKVEEADEEELVEAEGGL 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 429 LRFDGWTKVMPAlrKGDEDRILPAVDKGDTLTLIELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508
Cdd:COG0551 422 LEVLGEEEEDDE--DEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRYTTELLLKKLEEEGGGGRGTTATIIILILKRR 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 509 YVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHEAEWKGVLDNFFTDFTQQLDKAEKDPEEGGmR 588
Cdd:COG0551 500 YVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGEEE-L 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYalsPKerCKTTINLvPENEVLNVlegddaetnalrakrRCQKCGTA 668
Cdd:COG0551 579 SEEDEVLGEKCPKCGKPLVIKKGRYGKFLGCSNY---PE--CKYTKPL-PKPEVTGV---------------KCPKCGKK 637
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507082503 669 MDsyLIDPK--RKLHVCGNNPTCDgyeieegeFRIKgyDGPI-VECEKCGSEMHLKMGRFGkymaCTNDECKN 738
Cdd:COG0551 638 LV--LRKSKkgKVFYGCSNYPKCK--------FTEW--DKPVkEPCPKCGSPLVEKKTKKG----CANKLCGY 694
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
5-554 |
4.88e-49 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 186.68 E-value: 4.88e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 5 LVIVESPAKAKTINKYLGNDYVVKS---SVGHIRDLPTSgsATKKSADST--------------------STKTAKKPKK 61
Cdd:PTZ00407 12 LVIVESPNKVIKVEGLLSDPKVIPDwsfKQSHLRRIGTG--AEKAVAMATtghfmalkeitwspqasspaSVVGAGDEPF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 62 DERGALVNrmgvdpwhnWDARYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIAWH----LREVIGGDDTRY 134
Cdd:PTZ00407 90 PSNGTLAE---------YTLEWELLPGRriqETLERYIEEKADNVTEIILATDPDREGELIAVHalqtIKRLYPKLKVPF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 135 SRVVFNEITKNAIRQAFEK--PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIK 212
Cdd:PTZ00407 161 SRAYMHSITEDGIRKAMRErhVEACDYDLANAAETRHAMDRIFGFLGSSVVRAANSQMRSIGRVQTPALILINEREDKIK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 213 AFVPEE--FWEIDA--NTTTPGGDALPLEVTHQNDKPFRPVNREQTLAAVSLLEKARYS-----VLEREDKPTSSK--PG 281
Cdd:PTZ00407 241 AFLESNksTFEVQAmcQFPSPHGTTFSQVVTITPDRKGGASHWATEAEARRCLEQWKLNnctgfSVPLEPKPQPSVvpPP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRDYISDNFGKKYL------------- 348
Cdd:PTZ00407 321 QPFTMATAIAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDSTRIDESALPDIYAAVKKEFGKEFLyrledrtvsaqeg 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 349 -----PESANQYASKENS-------QEAHEAIRPSDVAVQAESLKdMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV- 415
Cdd:PTZ00407 401 kgskkTGKKRSTKQKKGAdtpvgnvEDAHEAIRPTNIDTTGESLS-LSPPTRAVYDLVRRNTLAVFMIPMKTEKIVATVk 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 416 ---GAGD-FRLKARGRILRFDGWTKvmpALRKGDEDRILPAVDKGDTLT------------------------------- 460
Cdd:PTZ00407 480 ftsGSGEkLEFELQGKRVVEPGWTR---AFHKGDKGTTGPAEETDEDITaveegapvvpslsqeefkaimnlrsqlgsgv 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 461 ---LIELTPAQ---HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR-RFYAEKMGEIVTDRLEEN 533
Cdd:PTZ00407 557 qkgFFELRSPQvreNRPVPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARGYIAVNPKgRCETTPVGRMLVETAKST 636
|
650 660
....*....|....*....|.
gi 507082503 534 FRELMNYDFTAQMEDSLDQVA 554
Cdd:PTZ00407 637 FPSIVDIGFTAAFEKKLDRIA 657
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
1-515 |
5.00e-45 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 174.86 E-value: 5.00e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 1 MGKALVIVESPAKAKTINKYLG-----------NDYVVKSSVGHIRDLptsgsatkksadststktaKKPKKDE--RGAl 67
Cdd:PRK08173 1 MSKALIIAEKPSVANDIARALGgftkhdeyfesDEYVLSSAVGHLLEI-------------------AAPEEYEvkRGK- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 68 vnrmgvdpwhnWD-ARYEVLPGK------EKVVSELKQLAEKA-----DHIYLATDLDREGEAIAWHLREVIGGDDTrYS 135
Cdd:PRK08173 61 -----------WSfAHLPVIPPHfdlnpiAKTESRLKVLTKLIkrkdvTRLINACDAGREGELIFRLIAQHAKAKKP-VK 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 136 RVVFNEITKNAIRQAFEK--PGELNIDRVNAQQARRFMDRVVGYMVSpllwkkiaRGLSA-------------GRVQSVA 200
Cdd:PRK08173 129 RLWLQSMTPQAIRDGFANlrSDEDMQPLADAARCRSEADWLVGINGT--------RAMTAfnskgggfflttvGRVQTPT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 201 VRLVVEREREIKAFVPEEFWEIDANTTTPGGD--ALPLEVTHQNDKpFRPVNREQTL----AAVSLLEKAR--YSVLERE 272
Cdd:PRK08173 201 LSIVVEREEKIRRFVPRDYWEVRAEFVAAAGFyeGRWFDPKFKKDE-FDPEKRASRLwseaAAEAIVAACRgkPGTVTEE 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 273 DKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRDYISDnfgkkyLPES 351
Cdd:PRK08173 280 SKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVKQTLEM------LKES 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 352 AN--QYASK--------------ENSQEA-HEAIRPSDVAvqAESLKDMEadaQKLYQLIWRQFVACQMTPAKYDSTTLT 414
Cdd:PRK08173 354 NNylPHAKQildkgwvkpnkrifDNSKISdHFAIIPTLQA--PKSLSEPE---QKLYDLVVKRFLAVFFPAAEFLVTTRI 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 415 VGAGDFRLKARGRILRFDGWtKVMPALRKGDEDRILPAVDKGDTLTLIELTPAQHFTKPPARFSEASLVKELE------- 487
Cdd:PRK08173 429 TEVAGHHFKTEGKVLVNPGW-LAVYGKEAQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklve 507
|
570 580 590
....*....|....*....|....*....|....*..
gi 507082503 488 ---------KRGIGRPSTYASIISTIQDRGYVRVENR 515
Cdd:PRK08173 508 ddelreamaEKGLGTPATRAAIIEGLLGEKYLVREGR 544
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
134-221 |
7.35e-43 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 150.43 E-value: 7.35e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 134 YSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR-GLSAGRVQSVAVRLVVEREREIK 212
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNgVLSAGRVQTPTLGLIVEREREIK 80
|
....*....
gi 507082503 213 AFVPEEFWE 221
Cdd:smart00436 81 NFVPKPYWE 89
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
3-154 |
2.44e-42 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 150.84 E-value: 2.44e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 3 KALVIVESPAKAKTINKYLGN------------DYVVKSSVGHIRDLPTsgsatkksadststktakkpkkDERGALVNR 70
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKgskkkgfygeggGYVVTASVGHLLELPF----------------------PEEYVDWDK 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 71 MGVDPWHNWDARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTRYSRVVFNEITKNAIRQA 150
Cdd:cd01028 59 DWPLELFPFEPKYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKCDNKPVKRAWFSEITPKAIREA 138
|
....
gi 507082503 151 FEKP 154
Cdd:cd01028 139 FKNL 142
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
3-629 |
1.01e-35 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 146.25 E-value: 1.01e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 3 KALVIVESPAKAKTI--------------NKYLGND-YVVKSSVGHIRDLptsgsatkKSADSTSTKTAKkpkkderGAL 67
Cdd:PRK14724 2 KTLVIAEKPSVAQDIvraltpvagkfekhDEHFESDsYVVTSAVGHLVEI--------QAPEEFDVKRGK-------WSF 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 68 VNRMGVDPwhnwdaRYEVLPgKEKVVSELK---QLAEKADHIYL--ATDLDREGEAIAWHLREVIGGDDTRYSRVV---- 138
Cdd:PRK14724 67 ANLPVIPP------YFDLKP-VDKTKTRLNavvKLAKRKDVTELvnACDAGREGELIFRLIEQYAGGAKGGLGKPVkrlw 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 139 FNEITKNAIRQAFE--KPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREI 211
Cdd:PRK14724 140 LQSMTPQAIRDGFDnlRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDggfflTTVGRVQTPTLSLVVEREEKI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 212 KAFVPEEFWEIDANTTTPGGDALPLEVTHQNDKPF--------RPVNREQTLAAVSLLEKARYSVLErEDKPTSSKPGAP 283
Cdd:PRK14724 220 RKFVSRDYWEIHAGFHAEAGEYLGKWFDPQWKKASddpearadRVWSEREARAIADAVRGKAATVTE-ESKPTTQASPLL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRDYIS--DNFGKKYLPESANQ------ 354
Cdd:PRK14724 299 FDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDYLPVAKQTFEmlATSGMRHLAPFAQQaldgny 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 355 -YASK---ENSQEA-HEAIRPSdvaVQAES-LKDMEadaQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI 428
Cdd:PRK14724 379 vRPSKrifDNSKVSdHFAIIPT---TQAPSgLSEAE---QKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKV 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 429 LRFDGWTKV--------MPALRKGDEDRILPAVDKGDTLTLIELTPAQHFTKPPARFSEASLVKELE------------- 487
Cdd:PRK14724 453 LVKPGWLAIygkeaaneVEDAKDGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMEsagkqidddelre 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 488 ---KRGIGRPSTYASIISTIQDRGYVRVENRRFY-AEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVAnheaewKGV 563
Cdd:PRK14724 533 amqEKGLGTPATRAAIIEGLLTEKYMLREGRELIpTAKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQME------KGQ 606
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507082503 564 L--DNFFTD---FTQQLDKAEKDPEEGGMrPNQMVLTSIDCPTCG-------RKMGIrTASTGVFLGCS-GYALSPKER 629
Cdd:PRK14724 607 LsrEAFMQQiaaMTEKLVKKAKEYDRDTI-PGDYATLSTPCPNCGgvvkenyRRYAC-TGANGAGEGCGfSFTKSPAGR 683
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
3-154 |
3.25e-20 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 88.06 E-value: 3.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 3 KALVIVESPAKAKTI------------------NKYLGNDYVVKSSVGHIRDLptsgsatkksadststktakkpkkDER 64
Cdd:cd03362 1 MVLIIAEKPSVAKAIakilgggskkkgkgryyeFYGEGGGYVVTWASGHLLEL------------------------DFP 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 65 GALVNRMGVDPWHN----WDARYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTR-YSRVVF 139
Cdd:cd03362 57 EEYDPWDKVWPLEDplfpAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVKRKpVKRAWF 136
|
170
....*....|....*
gi 507082503 140 NEITKNAIRQAFEKP 154
Cdd:cd03362 137 SSLTPKAIRRAFKNL 151
|
|
| Topo_Zn_Ribbon |
pfam08272 |
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two ... |
824-862 |
2.94e-19 |
|
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to pfam01396. However, this domain no longer bind zinc. Indeed, only one of the four cysteine residues remains.
Pssm-ID: 462415 [Multi-domain] Cd Length: 39 Bit Score: 81.56 E-value: 2.94e-19
10 20 30
....*....|....*....|....*....|....*....
gi 507082503 824 GNKSMVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVE 862
Cdd:pfam08272 1 GNPALVRFSRKTKEQYVLSEVDGKATGWLAAYTDGKWRE 39
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
4-142 |
4.65e-18 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 79.71 E-value: 4.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 4 ALVIVESPAKAKTINKYLG-NDYVVKSSVGHIRDLPTsgsatkksadststktakkpkkdergalvnrmgvdpwhnwdar 82
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGgGFQAVVAVLGHLLSLEK------------------------------------------- 37
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 83 yevlPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTRYSRVVFNEI 142
Cdd:pfam01751 38 ----GPKKKALKALKELALKAKEVILATDPDREGEAIALKLLELKELLENAGGRVEFSEL 93
|
|
| TOPRIM_TopoIA_RevGyr |
cd03361 |
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA ... |
4-154 |
2.34e-17 |
|
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173781 [Multi-domain] Cd Length: 170 Bit Score: 80.44 E-value: 2.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 4 ALVIVESPAKAKTINKYLG-----------------NDYV--VKSSVGHIRDLPTSG----------------SATKKSA 48
Cdd:cd03361 2 ALMIVESPNKARTIANFFGrpsvrrlgglvvyevstGDGVlmITASGGHVYDLVTKEgghgvveddgryvpvyDSIKRCR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 49 DSTSTKTAKKPKKDERGAlvnrmgvdpwhnwdaryEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG 128
Cdd:cd03361 82 DCGYQFTEDSDKCPRCGS-----------------ENIDDKLETLEALRELALEVDEVLIATDPDTEGEKIAWDVYLALR 144
|
170 180
....*....|....*....|....*.
gi 507082503 129 GDDTRYSRVVFNEITKNAIRQAFEKP 154
Cdd:cd03361 145 PYNKNIKRAEFHEVTRRAILEALRNP 170
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
3-131 |
5.98e-15 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 70.37 E-value: 5.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRdlptsgsatkksadststktakkpkkdergalvnrmgvdpwhnwdar 82
Cdd:smart00493 1 KVLIIVEGPADAIALEKAGGKRGNVVALGGHLL----------------------------------------------- 33
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 507082503 83 yevlpgKEKVVSELKQLAEKAdHIYLATDLDREGEAIAWHLREVIGGDD 131
Cdd:smart00493 34 ------SKEQIKLLKKLAKKA-EVILATDPDREGEAIAWELAELLKPAG 75
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
708-745 |
1.29e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 62.66 E-value: 1.29e-12
10 20 30
....*....|....*....|....*....|....*....
gi 507082503 708 IVECEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRN 745
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFVGCSNyPECRFTRPLKKN 39
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
3-139 |
3.73e-10 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 57.05 E-value: 3.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082503 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRdlptsgsatkksadststktakkpkkdergalvnrmgvdpwhnwdar 82
Cdd:cd00188 1 KKLIIVEGPSDALALAQAGGYGGAVVALGGHAL----------------------------------------------- 33
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 507082503 83 yevlpgkEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTRYSRVVF 139
Cdd:cd00188 34 -------NKTRELLKRLLGEAKEVIIATDADREGEAIALRLLELLKSLGKKVRRLLL 83
|
|
| Topo_Zn_Ribbon |
pfam08272 |
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two ... |
757-791 |
1.05e-07 |
|
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to pfam01396. However, this domain no longer bind zinc. Indeed, only one of the four cysteine residues remains.
Pssm-ID: 462415 [Multi-domain] Cd Length: 39 Bit Score: 48.82 E-value: 1.05e-07
10 20 30
....*....|....*....|....*....|....*....
gi 507082503 757 PLPELP--CEKSDAYFVLR--DGAAGIFLAANTFPKSRE 791
Cdd:pfam08272 1 GNPALVrfSRKTKEQYVLSevDGKATGWLAAYTDGKWRE 39
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
597-638 |
7.09e-05 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 40.70 E-value: 7.09e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 507082503 597 IDCPTCGRKMGIRTASTGVFLGCSGYalsPKerCKTTINLVP 638
Cdd:pfam01396 2 GKCPKCGGDLVLKRGRFGKFVGCSNY---PE--CRFTRPLKK 38
|
|
| |
