|
Name |
Accession |
Description |
Interval |
E-value |
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-949 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1680.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTD 80
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 81 HAGIATQMVVERKIAaEEGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:COG0525 83 HAGIATQAVVERQLA-EEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGaktadgKDYLVVATTRPETVLGDTGVAVNPEDP 240
Cdd:COG0525 162 YEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADG------SGYIVVATTRPETMLGDTAVAVHPEDE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 241 RYKDLIGKFVVLPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILTFDGDIRETAEVYdtKGEE 320
Cdd:COG0525 236 RYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKY--RGLD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 321 SDVYSNEIPAEFQKLerfaarkavvaavdalGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENG 400
Cdd:COG0525 314 RFEARKAIVADLEEL----------------GLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 401 DIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDNDGNVYVGRTEDEVRQENnlgADVQLRQDEDVLDTWFSSA 480
Cdd:COG0525 378 EIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPDGEVYVARTEPEACAKA---GSVNLTQDEDVLDTWFSSA 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 481 LWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKdengkpQVPFKTVYMTGLIRDDEGQKMSKSKG 560
Cdd:COG0525 455 LWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------EVPFKDVYIHGLVRDEQGRKMSKSKG 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 561 NVIDPLDMvdgislaellekrtgnmmqpqlaekiakrtekqfpdgIEPHGTDALRFTLAALASTGRDINWDMKRLEGYRN 640
Cdd:COG0525 529 NVIDPLDL-------------------------------------IDKYGADALRFTLAALASPGRDIKFDEERVEGYRN 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 641 FCNKLWNASRFVLMNTEDQDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWNQFCDWYLELT 720
Cdd:COG0525 572 FANKLWNASRFVLMNLEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELA 651
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 721 KPVMNGGSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVKviSGITADTIMLQPFPEYNAAQVDEAALADTEWL 800
Cdd:COG0525 652 KPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLP--PRKEGESIMLAPWPEADEELIDEEAEAEFEWL 729
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 801 KQAIVAVRNIRAEMNIAPGKPLELLLRGCSADAMRRVNDNRSFLLNLARLESITVLpADDKGPVSVTKIIDGAELLIPMA 880
Cdd:COG0525 730 KEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITIL-VDEKPEGAASAVVGGAEVFLPLE 808
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507080750 881 GLINKEDELARLAKEVAKIEGEIARIEGKLSNEGFVARAPEAVIAKEREKLDGYAEAKAKLIEQQAVIA 949
Cdd:COG0525 809 GLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARLK 877
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-950 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1626.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNgDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTD 80
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPD-DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 81 HAGIATQMVVERKIAAEeGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:PRK05729 84 HAGIATQMVVERQLAAE-GKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGaktadgKDYLVVATTRPETVLGDTGVAVNPEDP 240
Cdd:PRK05729 163 YEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADG------SDYLVVATTRPETMLGDTAVAVNPEDE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 241 RYKDLIGKFVVLPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILTFDGDIretaevydtkgee 320
Cdd:PRK05729 237 RYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTI------------- 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 321 sdvysNEIPAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENG 400
Cdd:PRK05729 304 -----NENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENG 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 401 DIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDNDGNVYVGRTEDEVRQENNlgadvqLRQDEDVLDTWFSSA 480
Cdd:PRK05729 379 EIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYVGREEPEAREKAL------LTQDEDVLDTWFSSA 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 481 LWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKdengkpQVPFKTVYMTGLIRDDEGQKMSKSKG 560
Cdd:PRK05729 453 LWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------QVPFKDVYIHGLVRDEQGRKMSKSKG 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 561 NVIDPLDMvdgislaellekrtgnmmqpqlaekiakrtekqfpdgIEPHGTDALRFTLAALASTGRDINWDMKRLEGYRN 640
Cdd:PRK05729 527 NVIDPLDL-------------------------------------IDKYGADALRFTLAALASPGRDIRFDEERVEGYRN 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 641 FCNKLWNASRFVLMNTEDQDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWNQFCDWYLELT 720
Cdd:PRK05729 570 FANKLWNASRFVLMNLEGADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELA 649
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 721 KPVMNGGSEselRGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVKVISGitADTIMLQPFPEYNAAQvDEAALADTEWL 800
Cdd:PRK05729 650 KPVLQEAAK---RATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGI--EESIMLAPWPEADEAI-DEAAEAEFEWL 723
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 801 KQAIVAVRNIRAEMNIAPGKPLELLLRGCSADAMRRVNDNRSFLLNLARLESITVLPADDKGPV-SVTKIIDGAELLIPM 879
Cdd:PRK05729 724 KELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPEgAASAVVGGAELFLPL 803
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507080750 880 AGLINKEDELARLAKEVAKIEGEIARIEGKLSNEGFVARAPEAVIAKEREKLDGYAEAKAKLIEQQAVIAA 950
Cdd:PRK05729 804 EGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLKA 874
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-932 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1403.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTD 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 81 HAGIATQMVVERKIAAEeGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:TIGR00422 81 HAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGAktadgKDYLVVATTRPETVLGDTGVAVNPEDP 240
Cdd:TIGR00422 160 YEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGS-----KDYLVVATTRPETMFGDTAVAVHPEDE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 241 RYKDLIGKFVVLPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILTFDGDIRETAevydtkgee 320
Cdd:TIGR00422 235 RYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENA--------- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 321 sdvysneipAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENG 400
Cdd:TIGR00422 306 ---------GKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEG 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 401 DIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWY-DNDGNVYVGRTEDEVRQENNLGADVQLRQDEDVLDTWFSS 479
Cdd:TIGR00422 377 EIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYcKECGEVYVAKEEPLPDDKTNTGPSVELEQDTDVLDTWFSS 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 480 ALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKdengkpQVPFKTVYMTGLIRDDEGQKMSKSK 559
Cdd:TIGR00422 457 SLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTG------QVPFKEVYIHGLVRDEQGRKMSKSL 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 560 GNVIDPLDMvdgislaellekrtgnmmqpqlaekiakrtekqfpdgIEPHGTDALRFTLAALASTGRDINWDMKRLEGYR 639
Cdd:TIGR00422 531 GNVIDPLDV-------------------------------------IEKYGADALRFTLASLVTPGDDINFDWKRVESAR 573
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 640 NFCNKLWNASRFVLMNTEDqDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWNQFCDWYLEL 719
Cdd:TIGR00422 574 NFLNKLWNASRFVLMNLSD-DLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIEL 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 720 TKPVMNGGSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVKvisgITADTIMLQPFPEYNAAQVDEAALADTEW 799
Cdd:TIGR00422 653 VKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK----EGADSIMLQSYPVVDAEFVDEEAEKAFEL 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 800 LKQAIVAVRNIRAEMNIAPGKPLELLLRGCSADAMRRVNDNRSFLLNLARLESITVLPADDKGPVSVTKIIDGAELLIPM 879
Cdd:TIGR00422 729 LKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVVELVPGFEIIIPV 808
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 507080750 880 AGLINKEDELARLAKEVAKIEGEIARIEGKLSNEGFVARAPEAVIAKEREKLD 932
Cdd:TIGR00422 809 KGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKLE 861
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-945 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1034.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDE----SKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQ 76
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAkslnSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 77 AGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEV 156
Cdd:PTZ00419 104 PGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 157 FVRLYKEDLIYRGKRLVNWDPKLRTAISDLEVENRESK----------------GSMWHIRYPLADGaktadGKDYLVVA 220
Cdd:PTZ00419 184 FVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEkptkitipgydkkvevGVLWHFAYPLEDS-----GQEEIVVA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 221 TTRPETVLGDTGVAVNPEDPRYKDLIGKFVVLPLVN-RRIPIVGDE-HADMEKGTGCVKITPAHDFNDYEVGKRHGLPMI 298
Cdd:PTZ00419 259 TTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFI 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 299 NILTFDGDIretaevydtkgeesdvysNEIPAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPML 378
Cdd:PTZ00419 339 NIFTLDGKI------------------NENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPML 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 379 TDQWYVRADVLAKPAVEAVENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAW-----------YDNDGNVyV 447
Cdd:PTZ00419 401 IPQWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYrviskgpetdpSDEEPWV-V 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 448 GRTEDEVRQE-----NNLGADVQLRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMM 522
Cdd:PTZ00419 480 ARSEEEALEKakkkfGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMM 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 523 TMHFIKdengkpQVPFKTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGISLAELLEK-RTGNMMQPQLaEKIAKRTEKQ 601
Cdd:PTZ00419 560 SLHLTD------KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKlYEGNLPEKEI-KRAIELQKKE 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 602 FPDGIEPHGTDALRFTLAALASTGRDINWDMKRLEGYRNFCNKLWNASRFVLMNTEDQD----CGFNGGEM--TLSLADR 675
Cdd:PTZ00419 633 FPNGIPECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFnlpnSTLFKPNNveSLPWEDK 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 676 WILAEFNQTIKAYREALDNFRFDIAAGILYEFTWNQFCDWYLELTKPVMNGGSESELR-GTRNTLVTVLEGLLRLAHPII 754
Cdd:PTZ00419 713 WILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKQSDGERKqHAQDVLHTVLDIGLRLLHPMM 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 755 PFITETIWQRV-KVISGItaDTIMLQPFPEYNAAQVDEAALADTEWLKQAIVAVRNIRAEMNIAPGKPLELLLRGCSADA 833
Cdd:PTZ00419 793 PFITEELYQRLpNYLRKS--ESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAEL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 834 MRRVNDNRSFLLNLARLESITVLPADDKG---PVSVTKIIDGAELLIPM--AGLINKEDELARLAKEVAKIEGEIARIEG 908
Cdd:PTZ00419 871 IELIESAENLISTLAKIGSVSVIPPIEEEaevPKGCGFDVVDNKVIIYLnlDEFIDLKKELAKLEKKLAKLQKSLESYLK 950
|
970 980 990
....*....|....*....|....*....|....*..
gi 507080750 909 KLSNEGFVARAPEAVIAKEREKLDGYAEAKaKLIEQQ 945
Cdd:PTZ00419 951 KISIPNYEDKVPEDVRKLNDEKIDELNEEI-KQLEQA 986
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
1-949 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 999.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 1 MEKTYNPQDIEQPLYEHWEKQGYFKPN-GDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGT 79
Cdd:PRK14900 15 LAKGYEHREVEARWYPFWQERGYFHGDeHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 80 DHAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVR 159
Cdd:PRK14900 95 DHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 160 LYKEDLIYRGKRLVNWDPKLRTAISDLEVENRESK-GSMWHIRYPLADGAKTadgkdyLVVATTRPETVLGDTGVAVNPE 238
Cdd:PRK14900 175 LHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHqGELWSFAYPLADGSGE------IVVATTRPETMLGDTAVAVHPL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 239 DPRYKDLIGKFVVLPLVNRRIPIVGD-EHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILTFDGdiRETAEVYDTK 317
Cdd:PRK14900 249 DPRYMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDG--RMTAEAGPLA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 318 GeesdvysneipaefqkLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAV 397
Cdd:PRK14900 327 G----------------LDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAV 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 398 ENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDNDGNVYVGRtedEVRQENNLGADVQLRQDEDVLDTWF 477
Cdd:PRK14900 391 EQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVAR---ETPEACSTCGKAELRQDEDVLDTWF 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 478 SSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKDengkpqVPFKTVYMTGLIRDDEGQKMSK 557
Cdd:PRK14900 468 SSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGE------VPFRTVYLHPMVRDEKGQKMSK 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 558 SKGNVIDPLDMvdgislaellekrtgnmmqpqlaekiakrtekqfpdgIEPHGTDALRFTLAALASTGRDINWDMKRLEG 637
Cdd:PRK14900 542 TKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTAQGRDIKLAKERIEG 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 638 YRNFCNKLWNASRFVLMNTED-QDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWNQFCDWY 716
Cdd:PRK14900 585 YRAFANKLWNASRFALMNLSGyQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWY 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 717 LELTKPVMNGGSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQ--RVKVISGITADTIMLQPFPEYNAaqVDEAAL 794
Cdd:PRK14900 665 IELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHvlRAQVGASAWADSVLAAEYPRKGE--ADEAAE 742
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 795 ADTEWLKQAIVAVRNIRAEMNIAPGKPLELLLRGCSADAMRRVND-----NRSFLLNLARLESITVLP--ADDKGPVSVT 867
Cdd:PRK14900 743 AAFRPVLGIIDAVRNIRGEMGIPWKVKLGAQAPVEIAVADPALRDllqagELARVHRVAGVEGSRLVVaaATAPAPQSAV 822
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 868 KIIDGAELLIPMAGLINKEDELARLAKEVAKIEGEIARIEGKLSNEGFVARAPEAVIAKEREKLDGYAEAKAKLIEQQAV 947
Cdd:PRK14900 823 GVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDRARAEELREKRGKLEAHRAM 902
|
..
gi 507080750 948 IA 949
Cdd:PRK14900 903 LS 904
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
11-941 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 809.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 11 EQPLYEHWEKQGYFKPNGDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGIATQMVV 90
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVV 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 91 ERKIAAEeGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGK 170
Cdd:PLN02943 146 EKMLASE-GIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGS 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 171 RLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGAKtadgkDYLVVATTRPETVLGDTGVAVNPEDPRYKDLIGKFV 250
Cdd:PLN02943 225 YMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGSE-----DFLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMA 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 251 VLPLV-NRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILTFDGDIRETAEVYdtkgeesdvysneip 329
Cdd:PLN02943 300 IVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAGLY--------------- 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 330 aefqkleRFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDIQFVPKQY 409
Cdd:PLN02943 365 -------WFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERF 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 410 ENMYFSWMRDIQDWCISRQLWWGHRIPAWY----DNDGNVYVGRTEDEV--RQENNLGADVQLRQDEDVLDTWFSSALWT 483
Cdd:PLN02943 438 EKIYNHWLSNIKDWCISRQLWWGHRIPVWYivgkDCEEDYIVARSAEEAleKAREKYGKDVEIYQDPDVLDTWFSSALWP 517
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 484 FSTLGWPE-NTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFikdeNGKpqVPFKTVYMTGLIRDDEGQKMSKSKGNV 562
Cdd:PLN02943 518 FSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEF----TGT--VPFSYVYLHGLIRDSQGRKMSKTLGNV 591
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 563 IDPLDMvdgislaellekrtgnmmqpqlaekiakrtekqfpdgIEPHGTDALRFTLAaLASTGRDINWDMKRLEGYRNFC 642
Cdd:PLN02943 592 IDPLDT-------------------------------------IKEFGTDALRFTLA-LGTAGQDLNLSTERLTSNKAFT 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 643 NKLWNASRFVLMNTEDQ----------DCGFNGGE--MTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWN 710
Cdd:PLN02943 634 NKLWNAGKFVLQNLPSQsdtsawehilACKFDKEEslLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWS 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 711 QFCDWYLELTKP-VMNGGSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVKVisgiTADTIMLQPFPEyNAAQV 789
Cdd:PLN02943 714 DFADWYIEASKTrLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPY----RKEALIVSPWPQ-TSLPK 788
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 790 DEAALADTEWLKQAIVAVRNIRAEMNIAPGKPLELLLRGcSADAMRRVNDNRSFLLNLARLESITV-----LPADDKGPV 864
Cdd:PLN02943 789 DLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVA-SAEVIEYISKEKEVLALLSRLDLQNVhftdsPPGDANQSV 867
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507080750 865 SVTkIIDGAELLIPMAGLINKEDELARLAKEVAKIEGEIARIEGKLSNEGFVARAPEAVIAKEREKLdgyAEAKAKL 941
Cdd:PLN02943 868 HLV-ASEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKA---AEAEEKI 940
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-631 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 801.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 13 PLYEHWEKQGYFKPN--GDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGIATQMVV 90
Cdd:pfam00133 1 QIYEFWDEQGYFKPEleKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 91 ERKIAAEEGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGK 170
Cdd:pfam00133 81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 171 RLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGAKTadgkdYLVVATTRPETVLGDTGVAVNPE------------ 238
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGA-----SLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyil 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 239 -------------------DPRYKDLIGKFVVLPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMIN 299
Cdd:pfam00133 236 aeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVIN 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 300 ILTFDGDIRETAevydtkgeesdvysneipAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLT 379
Cdd:pfam00133 316 PVDDDGTFTEEA------------------PDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRAT 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 380 DQWYVRADVLAKPAVEAVENgdIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDND-GNVYV---------GR 449
Cdd:pfam00133 378 PQWFVRMDELADQALEAVEK--VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDtEEVVCrgelfelvaGR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 450 TEDEVRQENNL---------GADvQLRQDEDVLDTWFSSALWTFSTLGWPE-NTDALRQFHPTSVMVSGFDIIFFWIARM 519
Cdd:pfam00133 456 FEEEGSIKWLHreakdklgyGKG-TLEQDEDVLDTWFSSGSWPFSTLGWPFvNTEEFKKFFPADMLLEGSDQTRGWFYRM 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 520 IMMTMHFIKDengkpqVPFKTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDgislaellekrtgnmmqpqlaekiakrte 599
Cdd:pfam00133 535 IMLSTALTGS------VPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID----------------------------- 579
|
650 660 670
....*....|....*....|....*....|..
gi 507080750 600 kqfpdgiePHGTDALRFTLaALASTGRDINWD 631
Cdd:pfam00133 580 --------KYGADALRLWL-ANSDYGRDINLS 602
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-948 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 791.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTD 80
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 81 HAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:PLN02381 176 HAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESK----------------GSMWHIRYPLADGAKTadgkdyLVVATTRP 224
Cdd:PLN02381 256 YKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKertllkvpgydkpvefGVLTSFAYPLEGGLGE------IVVATTRI 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 225 ETVLGDTGVAVNPEDPRYKDLIGKFVVLPLVNRRIPIVGD-EHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILTF 303
Cdd:PLN02381 330 ETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTD 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 304 DGDIretaevydtkgeesdvySNEIPAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWY 383
Cdd:PLN02381 410 DGKI-----------------NSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWF 472
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 384 VRADVLAKPAVEAV---ENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWY-------DNDGNVY-----VG 448
Cdd:PLN02381 473 VNCSSMAKQALDAAidgENKKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYvtleddqLKELGSYndhwvVA 552
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 449 RTEDEVRQENN---LGADVQLRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMH 525
Cdd:PLN02381 553 RNESDALLEASqkfPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQ 632
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 526 FIKDengkpqVPFKTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGISLAELLEK-RTGNMMQPQLAekIAKRTEKQ-FP 603
Cdd:PLN02381 633 LGGD------VPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHKRlEEGNLDPKELV--VAKEGQKKdFP 704
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 604 DGIEPHGTDALRFTLAALASTGRDINWDMKRLEGYRNFCNKLWNASRFVLMNTEDQ---DCGFNGGEMTLSLadRWILAE 680
Cdd:PLN02381 705 NGIAECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKLGDDytpPATLSVETMPFSC--KWILSV 782
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 681 FNQTIKAYREALDNFRFDIAAGILYEFTWNQFCDWYLELTKPVMNGGS---ESELRGTRNTLVTVLEGLLRLAHPIIPFI 757
Cdd:PLN02381 783 LNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNpefASERAAAQDTLWICLDTGLRLLHPFMPFV 862
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 758 TETIWQRVKVISGIT-ADTIMLQPFPEYNAAQVDEAALADTEWLKQAIVAVRNIRAEmnIAPGKPLELL--LRGCSADAM 834
Cdd:PLN02381 863 TEELWQRLPQPKDHTrKDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLRAE--VLEKQKNERLpaFALCRNQEI 940
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 835 RR-VNDNRSFLLNLARLESITVLPADDKGP---VSVTKIIDGAELLIPMAGLINKEDELARLAKEVAKIEGEIARIEGKL 910
Cdd:PLN02381 941 AAiIKSHQLEILTLANLSSLKVLLSENDAPpagCAFENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKM 1020
|
970 980 990
....*....|....*....|....*....|....*...
gi 507080750 911 SNEGFVARAPEAVIAKEREKLdgyaeakAKLIEQQAVI 948
Cdd:PLN02381 1021 NASGYKEKVPANIQEEDARKL-------TKLLQELEFF 1051
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
33-630 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 578.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 33 ESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGIATQMVVERKIAAEeGKTRHDYGREAFID 112
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIE-GKTRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 113 KIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRTAISDLEVenre 192
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 193 skgsmwhirypladgaktadgkdylvvattrpetvlgdtgvavnpedprykdligkfvvlplvnrripivgdehadmekg 272
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 273 tgcvkitpahdfndyevgkrhglpminiltfdgdiretaevydtkgeesdvysneipaefqklerfaarkavvaavdalg 352
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 353 lleeikphdltvpyGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWG 432
Cdd:cd00817 156 --------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWG 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 433 HRIPAWYDNDGN-VYVGRTEDEVRQ-----ENNLGADVQLRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMV 506
Cdd:cd00817 222 HRIPAWYCKDGGhWVVAREEDEAIDkaapeACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLV 301
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 507 SGFDIIFFWIARMIMMTMHFIKdengkpQVPFKTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGIslaellekrtgnmm 586
Cdd:cd00817 302 TGHDIIFFWVARMIMRGLKLTG------KLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGY-------------- 361
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 507080750 587 qpqlaekiakrtekqfpdgiephGTDALRFTLAALASTGRDINW 630
Cdd:cd00817 362 -----------------------GADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-867 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 548.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTD 80
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 81 HAGIATqmvvERKIAAEEGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:PRK13208 86 DNGLPT----ERKVEKYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGaktadgkDYLVVATTRPETVLGDTGVAVNPEDP 240
Cdd:PRK13208 162 YKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDG-------EEIEIATTRPELLPACVAVVVHPDDE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 241 RYKDLIGKFVVLPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILTFDGDIRETAEVYDTKGEE 320
Cdd:PRK13208 235 RYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 321 SdvySNEIPAEfqKLERfaarkavvaavdaLGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVEng 400
Cdd:PRK13208 315 E---ARKKIVE--DLKS-------------GGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGK-- 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 401 DIQFVP----KQYENmyfsWMRDIQ-DWCISRQLWWGHRIPAWY-DNDGNVYVGRTED----------EVRQENNLGADv 464
Cdd:PRK13208 375 EINWYPehmrVRLEN----WIEGLNwDWCISRQRYFGTPIPVWYcKDCGHPILPDEEDlpvdptkdepPGYKCPQCGSP- 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 465 QLRQDEDVLDTWFSSAL-WTFSTlGWPENTDALRQFHPTSVMVSGFDIIFFW----IARMIMmtmhfikdENGKpqVPFK 539
Cdd:PRK13208 450 GFEGETDVMDTWATSSItPLIVT-GWERDEDLFEKVFPMDLRPQGHDIIRTWlfytILRAYL--------LTGK--LPWK 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 540 TVYMTGLIRDDEGQKMSKSKGNVIDPLdmvdgislaELLEKrtgnmmqpqlaekiakrtekqfpdgiepHGTDALRFTlA 619
Cdd:PRK13208 519 NIMISGMVLDPDGKKMSKSKGNVVTPE---------ELLEK----------------------------YGADAVRYW-A 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 620 ALASTGRDINWDMKRLEGYRNFCNKLWNASRFVLMNTEDQDcgfNGGEMTLSLADRWILAEFNQTIKAYREALDNFRFDI 699
Cdd:PRK13208 561 ASARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLHFSADPE---PDKAEVLEPLDRWILAKLAKVVEKATEALENYDFAK 637
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 700 AAGILYEFTWNQFCDWYLELTKP-VMNGGSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVKVISgitadtIML 778
Cdd:PRK13208 638 ALEEIESFFWHVFCDDYLELVKSrAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGGS------VHR 711
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 779 QPFPEYNAAQVDEAALADTEWLKQAIVAVRNIRAEMNIAPGKPLELLLRGcSADAMRRVNDNRSFLLNLARLESITVLPA 858
Cdd:PRK13208 712 ASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVY-GPADLELLEAAEEDLKAAGNIEELELVEG 790
|
....*....
gi 507080750 859 DDKGPVSVT 867
Cdd:PRK13208 791 DPELEVEII 799
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
41-877 |
1.02e-99 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 333.59 E-value: 1.02e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 41 PPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTD-HaGiatqMVVERKIAAEEGKTR---HDYGREAFIDK--- 113
Cdd:COG0060 54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-G----LPIELKVEKELGIKKkdiEKVGIAEFREKcre 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 114 -IWQWKAEsggtITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRTAISDLEVE--N 190
Cdd:COG0060 129 yALKYVDE----QREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEykD 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 191 RESKgSMWhIRYPLADGAKTADGKD-YLVVATTRPETVLGDTGVAVNPE---------DPRY------------------ 242
Cdd:COG0060 205 VTSP-SIY-VKFPVKDEKALLLLEDaYLVIWTTTPWTLPANLAVAVHPDidyvlvevtGGERlilaealveavlkelgie 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 243 ----------KDLIGK-----FVVLPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILtfDGDI 307
Cdd:COG0060 283 dyevlatfkgAELEGLryehpFYYVVGYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPV--DDDG 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 308 RETAEVYDTKGE---ESDVysnEIpaeFQKL-ERfaarkavvaavdalGLL---EEIK---PHDL---Tvpygdrggvvi 374
Cdd:COG0060 361 RFTEEAPLFAGLfvkDANP---AI---IEDLkER--------------GALlarEKIThsyPHCWrckT----------- 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 375 ePML---TDQWYVRADVLAKPAVEAVEngDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDND-GNVY---- 446
Cdd:COG0060 410 -PLIyraTPQWFISMDKLRDRALEAIE--KVNWIPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDcGELHrtee 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 447 -VGRTEDEVRQEnnlGADV----------------------QLRQDEDVLDTWF-SSALWtFSTLgwpENTDALRqfhpt 502
Cdd:COG0060 487 vIGSVAELLEEE---GADAwfeldlhrpfldetlkcpkcggTMRRVPDVLDVWFdSGSMH-FAVL---ENREELH----- 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 503 svmvsgfdiiffWIARMIM----------MTMHFI----KDengkpQVPFKTVYMTGLIRDDEGQKMSKSKGNVIDPLDM 568
Cdd:COG0060 555 ------------FPADFYLegsdqtrgwfYSSLLTstalFG-----RAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEV 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 569 vdgislaellekrtgnmmqpqlaekiakrtekqfpdgIEPHGTDALRFTLAAlASTGRDINWDMKRLEGYRNFCNKLWNA 648
Cdd:COG0060 618 -------------------------------------IDKYGADILRLWVAS-SDYWGDLRFSDEILKEVRDVYRRLRNT 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 649 SRFVLMNTEDqdcgFNGGEMTLSLA-----DRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWNQFCDWYLELTKPV 723
Cdd:COG0060 660 YRFLLANLDD----FDPAEDAVPYEdlpelDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDR 735
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 724 MNGGSESEL--RGTRNTLVTVLEGLLRLAHPIIPFITETIWQrvkVISGITADTIMLQPFPEYNAAQVDEAALADTEWLK 801
Cdd:COG0060 736 LYTEAADSLdrRAAQTTLYEVLETLVRLLAPILPFTAEEIWQ---NLPGEAEESVHLADWPEVDEELIDEELEAKWDLVR 812
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 802 QAIVAVR----NIRAEMNIapGKPLE-LLLRGCSADAMRRVNDNRSFLLNLARLESITVLPADDKGPVSVTKIIDGAELL 876
Cdd:COG0060 813 EVRSAVLkaleAARKEKLI--RQPLEaAVVLYADEELAAALESLGDLLAEELNVSEVELVDDAEDLGKDALKALDVEGIS 890
|
.
gi 507080750 877 I 877
Cdd:COG0060 891 V 891
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
630-764 |
4.22e-68 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 223.20 E-value: 4.22e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 630 WDMKRLEGYRNFCNKLWNASRFVLMNTEDQDCGFNGGEmTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTW 709
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPE-SLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFW 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 507080750 710 NQFCDWYLELTKPVMNGGSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQR 764
Cdd:cd07962 80 NDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQR 134
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-892 |
3.35e-57 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 213.86 E-value: 3.35e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 11 EQPLYEHWEKQGYFKPNGD-ESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGIATQMV 89
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDrNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 90 VERKIAAEEgktrhdygREAFIDKIWQWKAESGG--TITRQM---RRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKED 164
Cdd:PLN02843 89 VLQSLDQEA--------RKELTPIKLRAKAAKFAkkTVDTQResfKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 165 LIYRGKRLVNWDPKLRTAISDLEVENRE---SKgSMWHIrYPLADGAKTADGK-------DYLVVATTRPETVLGDTGVA 234
Cdd:PLN02843 161 YIYRGRKPVHWSPSSRTALAEAELEYPEghvSK-SIYVA-FPVVSPSETSPEEleeflpgLSLAIWTTTPWTMPANAAVA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 235 VNP-------------EDPRYK------------------------DLIG--------KFVVL---------------PL 254
Cdd:PLN02843 239 VNDklqysvvevqsfsEDESTSggnkkkrpgnvlkeqqklflivatDLVPaleakwgvKLVVLktfpgsdlegcryihPL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 255 VNRRIPIV-GDEHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILTFDGDIreTAEVYDTKGeeSDVYSNEIPAEFQ 333
Cdd:PLN02843 319 YNRESPVViGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKF--TEEAGQFSG--LSVLGEGNAAVVE 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 334 KLErfaarkavvaaVDALGLLEEIKPHDLtvPYGDRggvVIEPML---TDQWYVRADVLAKPAVEAVENgdIQFVPKQYE 410
Cdd:PLN02843 395 ALD-----------EAGSLLMEEAYGHKY--PYDWR---TKKPTIfraTEQWFASVEGFRQAALDAIDK--VKWIPAQGE 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 411 NMYFSWMRDIQDWCISRQLWWGHRIPAWYDNDGNvYVGRTEDE-------VRQEnnlGADV------------------- 464
Cdd:PLN02843 457 NRIRAMVSGRSDWCISRQRTWGVPIPVFYHVETK-EPLMNEETiahvksiVAQK---GSDAwwymdvedllpekyrdkas 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 465 QLRQDEDVLDTWFSSA------LWTFSTLGWP-----ENTDALRQFHPTSVMVSgfdiiffwIArmimmtmhfikdENGK 533
Cdd:PLN02843 533 DYEKGTDTMDVWFDSGsswagvLGSREGLSYPadlylEGSDQHRGWFQSSLLTS--------VA------------TKGK 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 534 pqVPFKTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGislaellekrtgnmmqpqlaekiaKRTEKQFPdgiePHGTDA 613
Cdd:PLN02843 593 --APYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEG------------------------GKNQKQEP----AYGADV 642
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 614 LRFTLAALASTGrDINWDMKRL----EGYRnfcnKLWNASRFVLMNTEDQDCGFNGGEMTLSLADRWILAEFNQTIKAYR 689
Cdd:PLN02843 643 LRLWVASVDYTG-DVLIGPQILkqmsDIYR----KLRGTLRYLLGNLHDWKPDNAVPYEDLPSIDKYALFQLENVVNEIE 717
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 690 EALDNFRFDIAAGILYEFTWNQFCDWYLELTKPVMNGGSESEL--RGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVkv 767
Cdd:PLN02843 718 ESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFtrRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNL-- 795
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 768 isgitadtimlqPFPEYN--AAQVDEAALA--DTEWL------KQAIVAVRNIRAEMNiapgKPLElllrgcsadamrrv 837
Cdd:PLN02843 796 ------------PFQEDGsaAESVFEAGWPtpNEEWLsfpaedVDFWSLLLEVRDEVN----KVLE-------------- 845
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*
gi 507080750 838 nDNRSFLLNLARLESITVLPADDKgpvsvtkiiDGAELLIPMAGLINKEDELARL 892
Cdd:PLN02843 846 -SARNGKLIGASLEAKVYLHASDA---------SLAARLAELCGASNGADELRRI 890
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
35-630 |
6.17e-57 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 198.80 E-value: 6.17e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 35 FCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGIATQMVVERKiAAEEGKTRHdygREAFIDKI 114
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERK-GGRKKKTIW---IEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 115 WQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVnwdpklrtAISDlevenresk 194
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV--------RITE--------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 195 gsMWHIRYPLadgaktadgkdylvvattrpetvlgdtgvavnpedprYKDLIGKFvvlplvNRRIPIvgdehadmekgtg 274
Cdd:cd00668 141 --QWFFDMPK-------------------------------------FKEKLLKA------LRRGKI------------- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 275 cvkitpahdfndyevgkrhglpminiltfdgdiretaevydtkgeesdvysneipaefqklerfaarkavvaavdalgll 354
Cdd:cd00668 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 355 eeikphdltvpygdrggvviepmltdqwyvradvlakpaveavengdiqfVPKQYENMYFSWMRDIQDWCISRQLWWGHR 434
Cdd:cd00668 163 --------------------------------------------------VPEHVKNRMEAWLESLLDWAISRQRYWGTP 192
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 435 IPawydndgnvyvgrtedevrqennlgadvqlrqdEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFF 514
Cdd:cd00668 193 LP---------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRG 239
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 515 WIARMIMMTMHFikdeNGkpQVPFKTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVdgislaellekrtgnmmqpqlaeki 594
Cdd:cd00668 240 WANFWITMLVAL----FG--EIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV------------------------- 288
|
570 580 590
....*....|....*....|....*....|....*.
gi 507080750 595 akrtekqfpdgiEPHGTDALRFTLAALASTGRDINW 630
Cdd:cd00668 289 ------------EKYGADALRYYLTSLAPYGDDIRL 312
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-915 |
4.51e-51 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 194.32 E-value: 4.51e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 48 LHMGHAFQQTIMDTMIRYQRMQGKNTLW-----QAGTDHAGIAtqmvvERkIAAEEGKTRHDYGREAFI--DKIWQWK-- 118
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFpmafhVTGTPILGIA-----ER-IARGDPETIELYKSLYGIpeEELEKFKdp 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 119 -------AEsggTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRTAISD---LEV 188
Cdd:PRK12300 75 eyiveyfSE---EAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDhdlLDG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 189 ENRESkgsmwhIRYPLAdgaKTADGKD-YLVVATTRPETVLGDTGVAVNPE----------------------------- 238
Cdd:PRK12300 152 EEPEI------VEYTLI---KFEESEDlILPAATLRPETIFGVTNLWVNPDatyvkaevdgekwivskeaaeklsfqdrd 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 239 -----DPRYKDLIGKFVVLPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDY----EVGKRHGLPM----INILTFDG 305
Cdd:PRK12300 223 veiieEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELLDviepIPLIEVEG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 306 -------DIRETAEV---YDTKGEE--SDVYSneipAEFQKlerfaarkavvaavdalGLLEEIkphdlTVPYGDR---- 369
Cdd:PRK12300 303 ygefpakEVVEKLGIksqEDPELEEatKEVYR----AEFHK-----------------GVLKEN-----TGEYAGKpvre 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 370 ------------------------------GGVVIEPMLTDQWYVR--ADVLAKPAVEAVENgdIQFVP----KQYENMY 413
Cdd:PRK12300 357 arekitkdliekgiadimyefsnrpvycrcGTECVVKVVKDQWFIDysDPEWKELAHKALDN--MEIIPeeyrKEFENTI 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 414 FsWMRDiqdWCISRQLWWGHRIPaWYDN-------DGNVY-VGRTEDEVRQENNLGADvQLrqDEDVLDTWF---SSALW 482
Cdd:PRK12300 435 D-WLKD---RACARRRGLGTRLP-WDEEwiieslsDSTIYmAYYTIAHKIREYGIKPE-QL--TPEFFDYVFlgkGDPEE 506
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 483 TFSTLGWPENT-DALRQ----FHPTSVMVSGFDII-----FF------------WiARMIMMtmhfikdeNGkpqvpfkt 540
Cdd:PRK12300 507 VSKKTGIPKEIlEEMREeflyWYPVDWRHSGKDLIpnhltFFifnhvaifpeekW-PRGIVV--------NG-------- 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 541 vymTGLIrddEGQKMSKSKGNVIdPLDmvdgislaellekrtgnmmqpqlaekiakrtekqfpDGIEPHGTDALRFTLAA 620
Cdd:PRK12300 570 ---FVLL---EGKKMSKSKGNVI-PLR------------------------------------KAIEEYGADVVRLYLTS 606
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 621 LASTGRDINWDMKRLEGYRNFCNKLWNasrFVLMNTEDqdcgfnGGEMTLSLADRWILAEFNQTIKAYREALDNFRFDIA 700
Cdd:PRK12300 607 SAELLQDADWREKEVESVRRQLERFYE---LAKELIEI------GGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDA 677
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 701 AG-ILYEFTwNQFcDWYLELTKpvmnggseselRGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVKvisgiTADTIMLQ 779
Cdd:PRK12300 678 VQeAFYELL-NDL-RWYLRRVG-----------EANNKVLREVLEIWIRLLAPFTPHLAEELWHKLG-----GEGFVSLE 739
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 780 PFPEYNAAQVDEAALADTEWLKQAIVAVRNIraeMNIAPGKPlelllrgcsadamrrvndnrsfllnlarlESITVLPAD 859
Cdd:PRK12300 740 KWPEPDESKIDEEAELAEEYVKRLIEDIREI---LKVAKIKP-----------------------------KKVYIYVAP 787
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*.
gi 507080750 860 DKgPVSVTKIIDGAELLIPMAGLINKEDELARLAKEVAKIEGEIARIEGKLSNEGF 915
Cdd:PRK12300 788 DW-KYEVLEIAAENGDVKEAIKELMKDEELRKHGKEVAKLAQKIVKEVLKLDKEVR 842
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-819 |
2.51e-50 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 191.42 E-value: 2.51e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESKESF--CIMIPPPnvTGSLHMGHAFQQTIMDTMIRYQRMQGKNTL---- 74
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYyvLDMFPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLhpmg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 75 WQA-G--TDHAGIatqmvvERKIAAEEgktrhdygreafidkiwqWKAESGGTITRQMRRLGNSVDWERERFTMDEglsn 151
Cdd:COG0495 79 WDAfGlpAENAAI------KNGVHPAE------------------WTYENIANMRRQLKRLGLSYDWSREIATCDP---- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 152 avkE-------VFVRLYKEDLIYRGKRLVNWDPKLRTAI------------SDLEVENRESKgsMWHIR---YplAD--- 206
Cdd:COG0495 131 ---EyykwtqwIFLQLYEKGLAYRKEAPVNWCPVDQTVLaneqvidgrcwrCGAPVEKKELP--QWFLKitdY--ADell 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 207 -------------------------GA----KTADGKDYLVVATTRPETVLGDTGVAVNPEDP----------------- 240
Cdd:COG0495 204 ddldkldgwpekvktmqrnwigrseGAevdfPVEGSDEKITVFTTRPDTLFGATFMVLAPEHPlvkelatpeqnaavaaf 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 241 ----RYKDLI--------------GKFVVLPLVNRRIPI-VgdehAD---MEKGTGCVKITPAHDFNDYEVGKRHGLPMI 298
Cdd:COG0495 284 ieeaKKKSEIertsetkektgvftGLYAINPLTGEKIPIwI----ADyvlMDYGTGAVMAVPAHDQRDFEFAKKYGLPIK 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 299 N-ILTFDGD-IRETAEVYDTKGE--ESDVYSN-EIPAEFQKLERFaarkavvaavdalglLEEIKphdltvpygdrggvv 373
Cdd:COG0495 360 QvIAPEDGDdPDILEEAYTGDGVliNSGEFDGlDSEEAKEAIIEW---------------LEEKG--------------- 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 374 iepmltdqwyvradvLAKPAVeavengdiqfvpkQYenmyfswmRdIQDWCISRQLWWGHRIPAWYDNDGNVyVGRTEDE 453
Cdd:COG0495 410 ---------------LGKRKV-------------NY--------R-LRDWLISRQRYWGEPIPIIHCEDCGV-VPVPEDQ 451
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 454 --VR----------QENNLGAD-----VQL-------RQDEDVLDTWF-SSalwtfstlgW-------PENTDAlrqfhp 501
Cdd:COG0495 452 lpVElpedvdfdptGGSPLARApewvnVTCpkcggpaRRETDTMDTFVdSS---------WyylrytdPHNDEA------ 516
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 502 tsvMVSgFDIIFFWI------------------ARMIMMTMH---FIK-DEngkpqvPFKTVYMTGLIRD--------DE 551
Cdd:COG0495 517 ---PFD-PEAANYWLpvdqyiggiehailhllyARFFTKVLRdlgLVSfDE------PFKRLLTQGMVLEvgkdgvviGG 586
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 552 GQKMSKSKGNVIDPLDMvdgislaellekrtgnmmqpqlaekiakrtekqfpdgIEPHGTDALRFTLAALASTGRDINWD 631
Cdd:COG0495 587 IEKMSKSKGNVVDPDEI-------------------------------------IEKYGADTLRLFEMFAGPPERDLEWS 629
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 632 MKRLEGYRNFCNKLWnasRFVLMNTEDQDCGFNggemTLSLADRWILAEFNQTIKAYREALDNFRFD--IAAgiLYEFTw 709
Cdd:COG0495 630 DSGVEGAYRFLNRVW---RLVVDEAEALKLDVA----DLSEADKELRRALHKTIKKVTEDIERLRFNtaIAA--LMELV- 699
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 710 NqfcdwylELTKPVMNGGSESELrgtrntLVTVLEGLLRLAHPIIPFITETIWQRVKvisgiTADTIMLQPFPEYnaaqv 789
Cdd:COG0495 700 N-------ALYKAKDSGEADRAV------LREALETLVLLLAPFAPHIAEELWERLG-----HEGSVADAPWPEA----- 756
|
970 980 990
....*....|....*....|....*....|..
gi 507080750 790 DEAALADTEwlKQAIVAVrN--IRAEMNIAPG 819
Cdd:COG0495 757 DEAALVEDE--VTIVVQV-NgkVRGKIEVPAD 785
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
674-826 |
2.04e-45 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 159.88 E-value: 2.04e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 674 DRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWNQFCDWYLELTKPVMNGGSESELrgTRNTLVTVLEGLLRLAHPI 753
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR--AQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507080750 754 IPFITETIWQRvkvisgitaDTIMLQPFPEyNAAQVDEAALADTEWLKQAIVAVRNIRAEMNIAPGKPLELLL 826
Cdd:pfam08264 79 MPFITEELWQK---------ESIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
3-848 |
8.61e-37 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 150.26 E-value: 8.61e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 3 KTYNPQDIEQPLYEHWEKQGYFKPN--GDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTD 80
Cdd:PLN02882 6 KDFSFPKQEEKILSLWSEIDAFKTQlkRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 81 HAGIAtqmvVERKIAAEEGKTRHDYGREAFIDKiwqWKAESGGTITRQMR-------RLGNSVDWERERFTMDEGLSNAV 153
Cdd:PLN02882 86 CHGLP----VEYEIDKKLGIKRRDDVLKMGIDK---YNEECRSIVTRYSKewektvtRTGRWIDFENDYKTMDPKFMESV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 154 KEVFVRLYKEDLIYRGKRLVNWDPKLRTAISDLEV--ENRESKGSMWHIRYPLADGAKTADgkdyLVVATTRPETVLGDT 231
Cdd:PLN02882 159 WWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNYKDVSDPAVMVSFPIVGDPDNAS----FVAWTTTPWTLPSNL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 232 GVAVNPE------------------DPRYKDLIG----------------------KFVVLPLVNRRI-PI--------- 261
Cdd:PLN02882 235 ALCVNPNftyvkvrnkytgkvyivaESRLSALPTakpkskkgskpenaaegyevlaKVPGSSLVGKKYePLfdyfsefsd 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 262 -----VGDEHADMEKGTGCVKITPAHDFNDYEVGKRHG-------LPminiLTFDGDIRETAEVYDTKGEESDVYSNEIP 329
Cdd:PLN02882 315 tafrvVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGiiekggnLP----VPVDDDGCFTEKVTDFSGRYVKDADKDII 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 330 AEFQKLERFaarkavvaavdalglleeIKPHDLT--VPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEavENGDIQFVPK 407
Cdd:PLN02882 391 AAIKAKGRL------------------VKSGSIThsYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLE--NNKQTYWVPD 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 408 QY-ENMYFSWMRDIQDWCISRQLWWGHRIPAWYDNDGN--VYVGRTE------------------DEVRQENNLGADV-Q 465
Cdd:PLN02882 451 YVkEKRFHNWLENARDWAVSRSRFWGTPLPIWISDDGEevVVIGSIAeleklsgvkvtdlhrhfiDHITIPSSRGPEFgV 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 466 LRQDEDVLDTWFSSALWTFSTLGWP-ENTDALRQFHPTSVMVSGFDIIFFWI-ARMIMMTMHFikdenGKPqvPFKTVYM 543
Cdd:PLN02882 531 LRRVDDVFDCWFESGSMPYAYIHYPfENKELFEKNFPADFVAEGLDQTRGWFyTLMVLSTALF-----DKP--AFKNLIC 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 544 TGLIRDDEGQKMSKSKGNVIDPLDMVDgislaellekrtgnmmqpqlaekiakrtekqfpdgiePHGTDALRFTLaalas 623
Cdd:PLN02882 604 NGLVLAEDGKKMSKSLKNYPDPNEVID-------------------------------------KYGADALRLYL----- 641
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 624 tgrdINWDMKRLEGYRnFCNK------------LWNASRFVLMNTE-------------DQDCGFNGGEMTlslaDRWIL 678
Cdd:PLN02882 642 ----INSPVVRAEPLR-FKEEgvfgvvkdvflpWYNAYRFLVQNAKrleveggapfvplDLAKLQNSANVL----DRWIN 712
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 679 AEFNQTIKAYREALDNFRFDIAAGILYEFTwNQFCDWYLELTKPVMNGGS-ESELRGTRNTLVTVLEGLLRLAHPIIPFI 757
Cdd:PLN02882 713 SATQSLVKFVREEMGAYRLYTVVPYLVKFI-DNLTNIYVRFNRKRLKGRTgEEDCRTALSTLYNVLLTSCKVMAPFTPFF 791
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 758 TETIWQRVKVISGITADTIMLQPFPEYNAAQVDEAALADTEWLKQAIVAVRNIRAEMNiapgKPLELLLRgcsadAMRRV 837
Cdd:PLN02882 792 TEVLYQNLRKVLPGSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHN----KPLKTPLK-----EMVVV 862
|
970
....*....|.
gi 507080750 838 NDNRSFLLNLA 848
Cdd:PLN02882 863 HPDAEFLDDIT 873
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
379-570 |
2.88e-30 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 122.73 E-value: 2.88e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 379 TDQWYVRADVLAKPAVEAVENgdIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDNDgnvyvgrTEDEVrqen 458
Cdd:cd00818 150 TPQWFIRVTKIKDRLLEANDK--VNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCED-------CGEVL---- 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 459 nlgadvqLRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWI-ARMIMMTMHFikdenGKPqvP 537
Cdd:cd00818 217 -------VRRVPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTRGWFySLLLLSTALF-----GKA--P 282
|
170 180 190
....*....|....*....|....*....|...
gi 507080750 538 FKTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVD 570
Cdd:cd00818 283 YKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVD 315
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
6-825 |
1.79e-29 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 127.01 E-value: 1.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 6 NPQDIE--QPLYEHWEKQGYFKPNGD--ESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDH 81
Cdd:PTZ00427 71 NPNIVEeeEKVLKYWKSIDAFNTSNKlaKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDC 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 82 AGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLY 161
Cdd:PTZ00427 151 HGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELY 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 162 KEDLIYRGKRLVNWDPKLRTAISDLEV--------------------------------ENRESKGSMWHIRY------P 203
Cdd:PTZ00427 231 KNNYVYKSFKVMPYSCKCNTPISNFELnlnykdtpdpsiiisfvlcsdfpkveeecnieEDKQLLGEKYSVLYnnkrenS 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 204 LADGAKTADGKDY-----LVVATTRPETVLGDTGVAVNP----------------------------------EDP---- 240
Cdd:PTZ00427 311 NNGNNNSTNNVCYaqhseILAWTTTPWTLPSNLALCVNEhftylrihhvksnrvvivgecrlewimkelkwnvEDLkivn 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 241 ----------RYKDLIGKFV-VLPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHGL--PMINILTFDGD- 306
Cdd:PTZ00427 391 rfkgkelkglRYKPLFTNFYeKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPEKNIFIDPLDa 470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 307 ----IRETAEVYDTKGEESDvysNEIPAEFQKLERFaarkavvaavdalgLLEEIKPHdlTVPYGDRGGVVIEPMLTDQW 382
Cdd:PTZ00427 471 ngyfTNEVEEVQNLYIKEAD---NVIKKKLKNENRL--------------LSNNTIVH--SYPFCWRSDTPLIYRAIPAW 531
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 383 YVRadvLAKPAVEAVENGDIQF-VPKQY-ENMYFSWMRDIQDWCISRQLWWGHRIPAWYDNDGNVYVGRTE--------- 451
Cdd:PTZ00427 532 FIR---VSNSTNELVKNNETTYwIPAHIkEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESikhleelsg 608
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 452 ------------DEVRQENNLGADV-QLRQDEDVLDTWFSSALWTFSTLGWPENTDAlRQFH---PTSVMVSGFDIIFFW 515
Cdd:PTZ00427 609 vknindlhrhfiDHIEIKNPKGKTYpKLKRIPEVFDCWFESGSMPYAKVHYPFSTEK-EDFHkifPADFIAEGLDQTRGW 687
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 516 IARMIMM-TMHFIKdengkpqVPFKTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDgislaellekrtgnmmqpqlaeki 594
Cdd:PTZ00427 688 FYTLLVIsTLLFDK-------APFKNLICNGLVLASDGKKMSKRLKNYPDPLYILD------------------------ 736
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 595 akrtekqfpdgiePHGTDALRFTLA-ALASTGRDINWDMKRL-EGYRNFCNKLWNASRFVLMNTEDQDCgFNGGEMTL-- 670
Cdd:PTZ00427 737 -------------KYGADSLRLYLInSVAVRAENLKFQEKGVnEVVKSFILPFYHSFRFFSQEVTRYEC-LNKKQFLFnt 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 671 -------SLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWNqFCDWYLELTKPVMNG--GSESELRgTRNTLVT 741
Cdd:PTZ00427 803 dyiykndNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIEN-LTNWYIRLNRDRMRGslGEENCLQ-SLCTTYR 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 742 VLEGLLRLAHPIIPFITETIWQRVKVI---------------------SGITADTIMLQPFPeynaaQVDEAALADTEW- 799
Cdd:PTZ00427 881 TLHLFTVLMAPFTPFITEYIYQQLRRVkstnehnennetgntkegdlnRGVIHKSVHFIMLP-----QVDEKYIIDYEIi 955
|
970 980 990
....*....|....*....|....*....|.
gi 507080750 800 -----LKQAIVAVRNIRAEMNIAPGKPLELL 825
Cdd:PTZ00427 956 eliekMKDVILLGRVLRERRKVASKKPLKSI 986
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-785 |
7.71e-29 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 124.55 E-value: 7.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 9 DIEQPLYEHWEKQGYFK-PNG-DESKESFCI--MIPPPNVTGsLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGI 84
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRtPDDvDTSKPKFYVldMFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 85 -ATQMVVERKIAAEEGKTRHdygreafIDKIwqwkaesggtiTRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKE 163
Cdd:PLN02563 163 pAEQYAIETGTHPKITTLKN-------IARF-----------RSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKR 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 164 DLIYRGKRLVNWDPKLRTAISDLEVENRES-KGSMWHIRYPL----------AD-------------GAKTA-------- 211
Cdd:PLN02563 225 GLAYQAEVPVNWCPALGTVLANEEVVDGLSeRGGHPVIRKPMrqwmlkitayADrlledlddldwpeSIKEMqrnwigrs 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 212 ------------DGKD---YLVVATTRPETVLGDTGVAVNPEDP---------------RYKDL---------------- 245
Cdd:PLN02563 305 egaeldfsvldgEGKErdeKITVYTTRPDTLFGATYLVVAPEHPllsslttaeqkeaveEYVDAasrksdlertelqkek 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 246 ----IGKFVVLPLVNRRIPI-VGDeHADMEKGTGCVKITPAHDFNDYEVGKRHGLPMINILT-FDGDIRETAEVYdtKGE 319
Cdd:PLN02563 385 tgvfTGSYAINPATGEAIPIwVAD-YVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKpADGNEDDAEKAY--TGE 461
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 320 ESDVYSNEIPAEFQklerfaarkavvaavdalGLLEEikphdltvpygDRGGVVIEpmltdqWyvradvlakpaVEAVEN 399
Cdd:PLN02563 462 GVIVNSSSSGLDIN------------------GLSSK-----------EAAKKVIE------W-----------LEETGN 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 400 GDIQFVPKqyenmyfswmrdIQDWCISRQLWWGHRIPAWYDNDGNVYVGRTEDEV--------------RQENNLGADVQ 465
Cdd:PLN02563 496 GKKKVNYK------------LRDWLFARQRYWGEPIPVVFLEDSGEPVPVPESDLpltlpelddftptgTGEPPLAKAVS 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 466 LRQDEDVLD-TWFS----------SALWTFSTLGWPENTDAL------RQFHPTSVMVSGFD--IIFFWIARMIMMTMHF 526
Cdd:PLN02563 564 WVNTVDPSSgKPARretntmpqwaGSCWYYLRFMDPKNSNALvdkekeKYWMPVDLYVGGAEhaVLHLLYARFWHKVLYD 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 527 IKDENGKPqvPFKTVYMTGLI---------RDDEGQKMSKSKGNVIDPLDMVDgISLAELLEKRTGNMMQ--PQL----- 590
Cdd:PLN02563 644 IGVVSTKE--PFQCLVNQGMIlgeveytafKDSDGEYVSADTADRLGELQQEK-IPEEKVIKSGDSFVLKddPSIrliar 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 591 AEKIAK-RTEKQFPDGI-EPHGTDALRFTLAALASTgRDIN-WDMKRLEGYRNFCNKLWNasrfVLMNTEDQDCGFNGGE 667
Cdd:PLN02563 721 AHKMSKsRGNVVNPDDVvSEYGADSLRLYEMFMGPL-RDSKtWSTSGVEGVHRFLGRTWR----LVVGAPLPDGSFRDGT 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 668 MTLSL-ADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTwNQFCDWyleltkpvmnggseselrgtRNTLVTVLEGL 746
Cdd:PLN02563 796 VVTDEePSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFT-NAAYKW--------------------DKVPREAIEPF 854
|
890 900 910
....*....|....*....|....*....|....*....
gi 507080750 747 LRLAHPIIPFITETIWQRVKvisgiTADTIMLQPFPEYN 785
Cdd:PLN02563 855 VLLLSPYAPHLAEELWFRLG-----HSNSLAYEPWPEAN 888
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
639-808 |
3.18e-27 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 109.18 E-value: 3.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 639 RNFCNKLWNASRFVLMNTEDqdCGFNGGEMTLSLA-----DRWILAEFNQTIKAYREALDNFRFDIAAGILYEFtWNQFC 713
Cdd:cd07961 11 RKVLLPLWNAYRFFVTYANL--DGFDPGKDDDAVAslnvlDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEF-IDELT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 714 DWYLELTKPVM-NGGSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVKVISGITADTIMLQPFPEYNAAQVDEA 792
Cdd:cd07961 88 NWYIRRNRKRFwGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPESVHLLDWPEVDESLIDEE 167
|
170
....*....|....*.
gi 507080750 793 ALADTEWLKQAIVAVR 808
Cdd:cd07961 168 LEEAMELVREIVELGR 183
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
421-763 |
3.68e-21 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 98.42 E-value: 3.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 421 QDWCISRQ-LWWGhrIPaWYDNDGNV-YVgrtedevrqennlgadvqlrqdedvldtWFSsALWTF-STLGWPENTDAL- 496
Cdd:PRK11893 199 KDLSISRTnFDWG--IP-VPGDPKHViYV----------------------------WFD-ALTNYlTALGYPDDEELLa 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 497 ---RQFHPTSVMVSGFDIIFF----WIArmimMTMHfikdeNGKPQvpFKTVYMTGLIRDDeGQKMSKSKGNVIDPLDMV 569
Cdd:PRK11893 247 elfNKYWPADVHLIGKDILRFhavyWPA----FLMA-----AGLPL--PKRVFAHGFLTLD-GEKMSKSLGNVIDPFDLV 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 570 DgislaellekrtgnmmqpqlaekiakrtekQFpdgiephGTDALRFTLAALASTGRDINWDMKRLEGYRN--FCNKLWN 647
Cdd:PRK11893 315 D------------------------------EY-------GVDAVRYFLLREIPFGQDGDFSREAFINRINadLANDLGN 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 648 -ASRFVLMNTEDQDcGFNGGEMTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTwnQFCDWYLELTKPVMNG 726
Cdd:PRK11893 358 lAQRTLSMIAKNFD-GKVPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALV--RAANKYIDEQAPWSLA 434
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 507080750 727 GSESELRGTrnTLVTVLEGLLRLA---HPIIPFITETIWQ 763
Cdd:PRK11893 435 KTDPERLAT--VLYTLLEVLRGIAvllQPVMPELAAKILD 472
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
37-228 |
1.62e-19 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 90.38 E-value: 1.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 37 IMIPPPNvtGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDhagiATQMVVERkiAAEEGKTRHDYGREAFIDKiwq 116
Cdd:cd00812 6 VMFPYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAEN--AAIKIGRDPEDWTEYNIKK--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 117 wkaesggtITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRtaisdlevenreskgs 196
Cdd:cd00812 75 --------MKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWCKLLD---------------- 130
|
170 180 190
....*....|....*....|....*....|..
gi 507080750 197 MWHIRYPLADGAKTAdgKDYLVVATTRPETVL 228
Cdd:cd00812 131 QWFLKYSETEWKEKL--LKDLEKLDGWPEEVR 160
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
886-944 |
3.81e-18 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 79.23 E-value: 3.81e-18
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 507080750 886 EDELARLAKEVAKIEGEIARIEGKLSNEGFVARAPEAVIAKEREKLDGYAEAKAKLIEQ 944
Cdd:pfam10458 3 EKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRER 61
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
398-763 |
3.82e-17 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 85.94 E-value: 3.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 398 ENGDIQfvpKQYENMYFSWMRD-IQDWCISRQLWWGHRIPawyDNDGNV-YVgrtedevrqennlgadvqlrqdedvldt 475
Cdd:COG0143 203 ENPDIQ---PEVRNEVLSWLKEgLQDLSISRDFDWGIPVP---GDPGKVfYV---------------------------- 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 476 WFSsALWTF--STLGWPENT---DALRQFHP----TSVMVSGFDIIFF----WIArMIMMTmhfikdenGKPQVpfKTVY 542
Cdd:COG0143 249 WFD-ALIGYisATKGYADDRglpEDFEKYWPapdtELVHFIGKDIIRFhaiiWPA-MLMAA--------GLPLP--KKVF 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 543 MTGLIrDDEGQKMSKSKGNVIDPLDMVDgislaellekrtgnmmqpqlaekiakrtekQFpdgiephGTDALRFTLAALA 622
Cdd:COG0143 317 AHGFL-TVEGEKMSKSRGNVIDPDDLLD------------------------------RY-------GPDALRYYLLREV 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 623 STGRDINWDMKRLEGyRN---FCNKLWN-ASRFVLM---NtedqdcgFNG---GEMTLSLADRWILAEFNQTIKAYREAL 692
Cdd:COG0143 359 PFGQDGDFSWEDFVA-RVnsdLANDLGNlASRTLSMihkY-------FDGkvpEPGELTEADEELLAEAEAALEEVAEAM 430
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507080750 693 DNFRFDIAAGILYEFTwnQFCDWYLELTKP--VMNGGSESELrgtRNTLVTVLEGLLRLA---HPIIPFITETIWQ 763
Cdd:COG0143 431 EAFEFRKALEEIMALA--RAANKYIDETAPwkLAKDEDPERL---ATVLYTLLEALRILAillKPFLPETAEKILE 501
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
632-815 |
1.34e-14 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 72.94 E-value: 1.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 632 MKRL-EGYRnfcnKLWNASRFVLMNTEDqdcgFNGGEMT-----LSLADRWILAEFNQTIKAYREALDNFRFDIAAGILY 705
Cdd:cd07960 6 LKQVaEAYR----KIRNTFRFLLGNLND----FDPAKDAvpyeeLLELDRYALHRLNELIKEVREAYENYEFHKVYQALN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 706 EFTWNQFCDWYLELTKPVM--NGGSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVKviSGITADTIMLQPFPE 783
Cdd:cd07960 78 NFCTVDLSAFYLDIIKDRLycDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLP--GEKKEESVFLEDWPE 155
|
170 180 190
....*....|....*....|....*....|..
gi 507080750 784 YNAAQVDEAALADTEWLkqaivavRNIRAEMN 815
Cdd:cd07960 156 LPEEWKDEELEEKWEKL-------LALRDEVN 180
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
633-753 |
6.98e-14 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 69.07 E-value: 6.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 633 KRLEGYRNFCNKLWNASRFVLMNTEdqdcGFNGGE--MTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWN 710
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKALG----GTQPKWdnELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNE 77
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 507080750 711 QfcDWYLELTKPVmnGGSESELRGTRNTLVTVLEGLLRLAHPI 753
Cdd:cd07375 78 L--NWYLDELKPA--LQTEELREAVLAVLRAALVVLTKLLAPF 116
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
37-764 |
3.89e-13 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 73.18 E-value: 3.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 37 IMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGIATqmvvERKiAAEEGKTrhdygREAFIDKIWQ 116
Cdd:TIGR00398 3 ITTALPYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKI----ELK-AEQEGLT-----PKELVDKYHE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 117 wkaesggTITRQMRRLGNSVDwereRF--TMDEGLSNAVKEVFVRLYKEDLIYrgkrlvnwdpklrtaisdleveNRESK 194
Cdd:TIGR00398 73 -------EFKDDWKWLNISFD----RFirTTDEEHKEIVQKIFQKLKENGYIY----------------------EKEIK 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 195 GsmwhirypladgaktadgkdylvvattrpetvlgdtgvAVNPEDPRYKdligkfvvlplvnrripivgdehADMEKGTG 274
Cdd:TIGR00398 120 Q--------------------------------------LYCPECEMFL-----------------------PDRYVEGT 138
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 275 CvkitpahdfndyevgkrhglPMINILTFDGDIREtaevydtkgeesdvysneipaefqklerfaarkavvaavdALGLL 354
Cdd:TIGR00398 139 C--------------------PKCGSEDARGDHCE----------------------------------------VCGRH 158
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 355 EEikPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDI-QFVPKQYENMYFSWMRD-IQDWCISRQL-WW 431
Cdd:TIGR00398 159 LE--PTELINPRCKICGAKPELRDSEHYFFRLSAFEKELEEWIRKNPEsGSPASNVKNKAQNWLKGgLKDLAITRDLvYW 236
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 432 GHRIPawYDNDGNVYVgrtedevrqennlgadvqlrqdedvldtWFSSALWTFSTLGWPENTDAlrqfhptsvmvsgfDI 511
Cdd:TIGR00398 237 GIPVP--NDPNKVVYV----------------------------WFDALIGYISSLGILSGDTE--------------DW 272
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 512 IFFWIARMIMMTMHFIkdenGKPQVPFKTVYMTGLIR----------------DDEGQKMSKSKGNVIDPLDMVDGIsla 575
Cdd:TIGR00398 273 KKWWNNDEDAELIHFI----GKDIVRFHTIYWPAMLMglglplptqvfshgylTVEGGKMSKSLGNVVDPSDLLARF--- 345
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 576 ellekrtgnmmqpqlaekiakrtekqfpdgiephGTDALRFTLAALASTGRDINWDMKRLEGYRN--FCNKLWN-ASRFV 652
Cdd:TIGR00398 346 ----------------------------------GADILRYYLLKERPLGKDGDFSWEDFVERVNadLANKLGNlLNRTL 391
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 653 LMntedQDCGFNG---GEMTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYE--FTWNQFCD----WYLELtkpv 723
Cdd:TIGR00398 392 GF----IKKYFNGvlpSEDITDEEDKKLLKLINEALEQIDEAIESFEFRKALREIMKlaDRGNKYIDenkpWELFK---- 463
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 507080750 724 mNGGSESELRGTRNTLVTVLEGLLRlahPIIPFITETIWQR 764
Cdd:TIGR00398 464 -QSPRLKELLAVCSMLIRVLSILLY---PIMPKLSEKILKF 500
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
662-765 |
1.06e-12 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 65.30 E-value: 1.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 662 GFNGGEMTLSLADRWILAEFNQTIKAYREALDNFRF-DIAAGILYEFTwnQFCDWYLELTKPVMNggseselrgtRNTLV 740
Cdd:cd07959 25 ETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFrEALKEGLYELQ--NDLDWYRERGGAGMN----------KDLLR 92
|
90 100
....*....|....*....|....*
gi 507080750 741 TVLEGLLRLAHPIIPFITETIWQRV 765
Cdd:cd07959 93 RFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
630-764 |
4.16e-10 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 58.00 E-value: 4.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 630 WDMKRLEGYRNFCNKLWnasRFVLMNTEDQDcgFNGGEMTLSLADRWILAEFNQTIKAYREALDNFRFD--IAAgiLYEF 707
Cdd:cd07958 1 WSDSGVEGAYRFLNRVW---RLVTELAEALA--APAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNtaIAA--LMEL 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 507080750 708 TwNqfcdwylELTKpvmnggSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQR 764
Cdd:cd07958 74 V-N-------ALYK------YKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEE 116
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
485-772 |
1.61e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 61.74 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 485 STLGWP-ENTDALRQFHPTSVMVSGFDII-F---FWIArMIMMTmhfikdenGKPqvPFKTVYMTG-LIRDDegQKMSKS 558
Cdd:PRK12267 237 TALGYGsDDDELFKKFWPADVHLVGKDILrFhaiYWPI-MLMAL--------GLP--LPKKVFAHGwWLMKD--GKMSKS 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 559 KGNVIDPLDMVDgislaellekrtgnmmqpqlaekiakrtekqfpdgiePHGTDALRFTLAALASTGRD----------- 627
Cdd:PRK12267 304 KGNVVDPEELVD-------------------------------------RYGLDALRYYLLREVPFGSDgdfspealver 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 628 INWDMkrlegyrnfCNKLWN-ASRFVLMNTEdqdcgFNGGEMTLSLA----DRWILAEFNQTIKAYREALDNFRFDIAAG 702
Cdd:PRK12267 347 INSDL---------ANDLGNlLNRTVAMINK-----YFDGEIPAPGNvtefDEELIALAEETLKNYEELMEELQFSRALE 412
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507080750 703 ILYEF--TWNQfcdwYLELTKP-VM--NGGSESELrgtRNTLVTVLEGLLRLAHPIIPFITET---IWQRVKVISGIT 772
Cdd:PRK12267 413 EVWKLisRANK----YIDETAPwVLakDEGKKERL---ATVMYHLAESLRKVAVLLSPFMPETskkIFEQLGLEEELT 483
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
219-318 |
2.57e-09 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 57.56 E-value: 2.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 219 VATTRPETVLGDTGVAVNPE----------DPRYKDLI-----------------------GKFVVLPLVNRRIPI-Vgd 264
Cdd:pfam13603 25 VFTTRPDTLMGVTFVALAPEhplveklaekNPEVAAFIeeckntseiertsetkekegvftGLYAIHPITGEKIPIwI-- 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 265 ehAD---MEKGTGCVKITPAHDFNDYEVGKRHGLPMINILT---FDGDIRETAEVYDTKG 318
Cdd:pfam13603 103 --ANfvlMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQpedGDLDLDIMTEAYTEEG 160
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
359-631 |
2.99e-09 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 60.00 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 359 PHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDIQFvPKQYENMYFSWMRD-IQDWCISRQLWWGHRIPa 437
Cdd:pfam09334 161 PTELINPKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPEW-PENVKNMVLEWLKEgLKDRAISRDLDWGIPVP- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 438 wyDNDGNV-YVgrtedevrqennlgadvqlrqdedvldtWFssalwtfstlgwpentDALRQFHPTSVMVSGFDIIF--F 514
Cdd:pfam09334 239 --GAEGKVfYV----------------------------WL----------------DAPIGYISATKELSGNEEKWkeW 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 515 WIARMIMMTMHFIkdenGKPQVPFKTVYMTGLIRDD----------------EGQKMSKSKGNVIDPLDMVDgislaell 578
Cdd:pfam09334 273 WPNDPDTELVHFI----GKDIIYFHTIFWPAMLLGAgyrlpttvfahgyltyEGGKMSKSRGNVVWPSEALD-------- 340
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 507080750 579 ekrtgnmmqpqlaekiakrtekQFPdgiephgTDALRFTLAALASTGRDIN--WD 631
Cdd:pfam09334 341 ----------------------RFP-------PDALRYYLARNRPETKDTDfsWE 366
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
377-570 |
5.81e-09 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 58.80 E-value: 5.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 377 MLTDQWYVRADV--LAKPAVEAVENgdIQFVPKQYENMyfswMRDIQDwcISRQLWWGHRIPaWydndgnvyvgrtedev 454
Cdd:cd00812 127 KLLDQWFLKYSEteWKEKLLKDLEK--LDGWPEEVRAM----QENWIG--CSRQRYWGTPIP-W---------------- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 455 rqennlgadvqlrqdEDVLDTWFSSALWTF-------STLGWPENTDALRQ----FHPTSVMVSGFDII----FFWIarm 519
Cdd:cd00812 182 ---------------TDTMESLSDSTWYYArytdahnLEQPYEGDLEFDREefeyWYPVDIYIGGKEHApnhlLYSR--- 243
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 507080750 520 imMTMHFIKDENGKPQVPFKTVYMTGLIRDdEGQKMSKSKGNVIDPLDMVD 570
Cdd:cd00812 244 --FNHKALFDEGLVTDEPPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIK 291
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
42-170 |
6.57e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 55.62 E-value: 6.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 42 PNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGIATQMVverkiAAEEGKTRHDYGRE--AFIDKIWQWka 119
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQK-----AEEEGVTPQELCDKyhEIFKDLFKW-- 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 507080750 120 esggtitrqmrrLGNSVDwereRF--TMDEGLSNAVKEVFVRLYKEDLIYRGK 170
Cdd:cd00814 82 ------------LNISFD----YFirTTSPRHKEIVQEFFKKLYENGYIYEGE 118
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
44-170 |
1.92e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 54.81 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 44 VTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGiatQMVVErkIAAEEGKTrhdygREAFIDKIwqwkaeSGG 123
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---QKIQQ--AAEKAGKT-----PQEYVDEI------SAG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 507080750 124 tITRQMRRLGNSVDwereRF--TMDEGLSNAVKEVFVRLYKEDLIYRGK 170
Cdd:PRK12267 79 -FKELWKKLDISYD----KFirTTDERHKKVVQKIFEKLYEQGDIYKGE 122
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
379-570 |
3.48e-07 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 53.30 E-value: 3.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 379 TDQWYVRADVLAKPAVEAVENGDIQFVPKQYENMYFSWMRD-IQDWCISRQLW-WGHRIPawyDNDGNV-YVgrtedevr 455
Cdd:cd00814 137 EEHYFFRLSKFQDRLLEWLEKNPDFIWPENARNEVLSWLKEgLKDLSITRDLFdWGIPVP---LDPGKViYV-------- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 456 qennlgadvqlrqdedvldtWF-------SSA-----LWTFSTLGWPENTdALRQFHptsvmvsGFDIIFF----WIArM 519
Cdd:cd00814 206 --------------------WFdaligyiSATgyyneEWGNSWWWKDGWP-ELVHFI-------GKDIIRFhaiyWPA-M 256
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 507080750 520 IMMTmhfikdENGKPQVPFKTVYMTglirdDEGQKMSKSKGNVIDPLDMVD 570
Cdd:cd00814 257 LLGA------GLPLPTRIVAHGYLT-----VEGKKMSKSRGNVVDPDDLLE 296
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
33-169 |
2.89e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 47.79 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 33 ESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAG--IATQmvverkiAAEEGKTrhdygreaf 110
Cdd:PLN02224 69 DTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATS-------AAANGRN--------- 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507080750 111 idkiwqwKAESGGTITRQMRRLGNSVDWERERF--TMDEGLSNAVKEVFVRLYKEDLIYRG 169
Cdd:PLN02224 133 -------PPEHCDIISQSYRTLWKDLDIAYDKFirTTDPKHEAIVKEFYARVFANGDIYRA 186
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
541-637 |
1.47e-04 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 45.53 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 541 VYMTGLIRDDEGQKMSKSKGNVIDpldmvdgisLAELLEKRTGNMMQPQLAEKIAKRTekqfpdgiephGTDALRFtlaA 620
Cdd:PRK01611 309 HQMVGLVRGGEGVKMSTRAGNVVT---------LDDLLDEAVGRARELIEEKEIAEAV-----------GIDAVRY---F 365
|
90 100
....*....|....*....|..
gi 507080750 621 LASTGRD----INWD-MKRLEG 637
Cdd:PRK01611 366 DLSRSRDkdldFDLDlALSFEG 387
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
515-579 |
3.24e-04 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 44.42 E-value: 3.24e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507080750 515 WIARMIMmtmhfikdeNGKPQVPFktVYmtGLIRDDEGQKMSKSKGNVidpldmvdgISLAELLE 579
Cdd:PRK00750 254 KIAREIL---------GGEPPEPF--VY--ELFLDKKGEKISKSKGNV---------ITIEDWLE 296
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
545-637 |
5.57e-04 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 43.60 E-value: 5.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 545 GLIRDDEGQKMSKSKGNVIDpldmvdgisLAELLEkrtgnMMQPQLAEKIAKRTEKQFPDGIEPHGTDALRFtlaALAST 624
Cdd:COG0018 370 GMVNLRDGEKMSTRAGTVVT---------LDDLLD-----EAVERAREIIEEKSEEEKEEIAEQVGIDAVRY---FDLSR 432
|
90
....*....|....*...
gi 507080750 625 GR----DINWD-MKRLEG 637
Cdd:COG0018 433 SRdkdlDFDLDlALSFEG 450
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
669-763 |
7.24e-04 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 40.55 E-value: 7.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 669 TLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTW--NQfcdwYLELTKP--VMNGGSESELrgtRNTLVTVLE 744
Cdd:cd07957 33 GLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELARaaNK----YIDETAPwkLAKEEDPERL---ATVLYVLLE 105
|
90 100
....*....|....*....|..
gi 507080750 745 GLLRLA---HPIIPFITETIWQ 763
Cdd:cd07957 106 LLRILAillSPFMPETAEKILD 127
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
9-74 |
8.42e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 43.52 E-value: 8.42e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080750 9 DIEQPLYEHWEKQGYFKPN----GDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTL 74
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAEagdePPKPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVL 86
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
531-570 |
1.64e-03 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 42.10 E-value: 1.64e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 507080750 531 NGKPQVPFktVYmtGLIRDDEGQKMSKSKGNVIDPLDMVD 570
Cdd:COG1384 268 GGEPPEGF--VY--ELFLDENGEKISKSKGNGLTVEEWLE 303
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
42-116 |
2.08e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 42.06 E-value: 2.08e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507080750 42 PNVTGSLHMGHAFQ--QTimDTMIRYQRMQGKNTLWQAGTDHAGIATqMVVerkiAAEEGKTrhdygREAFIDKIWQ 116
Cdd:PRK00133 11 PYANGPIHLGHLVEyiQA--DIWVRYQRMRGHEVLFVCADDAHGTPI-MLK----AEKEGIT-----PEELIARYHA 75
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
531-570 |
9.35e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 39.55 E-value: 9.35e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 507080750 531 NGKPQVPFktvyMTGLIRDDEGQKMSKSKGNVIDPLDMVD 570
Cdd:pfam01921 260 GGEPPEGF----PYELILLKGGGKMSSSKGNVITPEDWLE 295
|
|
| |
