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Conserved domains on  [gi|506390809|ref|WP_015910528|]
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(d)CMP kinase [Halorubrum lacusprofundi]

Protein Classification

(d)CMP kinase( domain architecture ID 11480180)

(d)CMP kinase catalyzes the phosphorylation of cytidine monophosphate (CMP) or dCMP to produce cytidine diphosphate (CDP) or dCDP, using ATP as the preferred phosphoryl donor

CATH:  3.40.50.300
EC:  2.7.4.25
Gene Ontology:  GO:0036431|GO:0006220|GO:0005524
PubMed:  10218107
SCOP:  4004025

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-180 1.17e-100

cytidylate kinase; Provisional


:

Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 287.86  E-value: 1.17e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAERDMTPVEFNEFAEEDPQIDRDLDRRLHEIATTRDDLVLE 80
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELAKERGMSLEEFNKYAEEDPEIDKEIDRRQLEIAEKEDNVVLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  81 SRLAGWLSADHADFRFWFDAPVSTRAERIAEREEKPVDRAKAETERREASEKKRYREYYDIDIGDLSIYDAAYNTARWGP 160
Cdd:PRK04182  81 GRLAGWMAKDYADLKIWLKAPLEVRAERIAEREGISVEEALEETIEREESEAKRYKEYYGIDIDDLSIYDLVINTSRWDP 160

                        170       180
                 ....*....|....*....|
gi 506390809 161 ERFIDVLVATIDAYDPATDE 180
Cdd:PRK04182 161 EGVFDIILTAIDKLLKAKDE 180
 
Name Accession Description Interval E-value
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-180 1.17e-100

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 287.86  E-value: 1.17e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAERDMTPVEFNEFAEEDPQIDRDLDRRLHEIATTRDDLVLE 80
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELAKERGMSLEEFNKYAEEDPEIDKEIDRRQLEIAEKEDNVVLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  81 SRLAGWLSADHADFRFWFDAPVSTRAERIAEREEKPVDRAKAETERREASEKKRYREYYDIDIGDLSIYDAAYNTARWGP 160
Cdd:PRK04182  81 GRLAGWMAKDYADLKIWLKAPLEVRAERIAEREGISVEEALEETIEREESEAKRYKEYYGIDIDDLSIYDLVINTSRWDP 160

                        170       180
                 ....*....|....*....|
gi 506390809 161 ERFIDVLVATIDAYDPATDE 180
Cdd:PRK04182 161 EGVFDIILTAIDKLLKAKDE 180
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1-172 9.83e-76

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 224.61  E-value: 9.83e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAERDMTPVEFNEFAEEDPQIDRDLDRRLHEIATTRDDLVLE 80
Cdd:TIGR02173   1 MIITISGPPGSGKTTVAKILAEKLSLKLISAGDIFRELAAKMGLDLIEFLNYAEENPEIDKKIDRRIHEIALKEKNVVLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   81 SRLAGWLSADHADFRFWFDAPVSTRAERIAEREEKPVDRAKAETERREASEKKRYREYYDIDIGDLSIYDAAYNTARWGP 160
Cdd:TIGR02173  81 SRLAGWIVREYADVKIWLKAPLEVRARRIAKREGKSLTVARSETIEREESEKRRYLKFYGIDIDDLSIYDLVINTSNWDP 160

                         170
                  ....*....|..
gi 506390809  161 ERfIDVLVATID 172
Cdd:TIGR02173 161 NN-VDIILDALD 171
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
1-178 9.39e-61

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 187.34  E-value: 9.39e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVsGGDIFREMAAERDMTPVEFNEFAEEDP-----------QIDRDLDRRLHE 69
Cdd:COG1102    1 MVITISREPGSGGTTIAKRLAEKLGLPLY-DGEILREAAKERGLSEEEFEKLDEKAPsllyrdtaeedEIDRALDKVIRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  70 IATtRDDLVLESRLAGWLSADH-ADFRFWFDAPVSTRAERIAEREEKPVDRAKAETERREASEKKRYREYYDIDIGDLSI 148
Cdd:COG1102   80 LAR-KGNCVIVGRLADWILRDRpNVLKVFLTAPLEVRVKRIAEREGISEEEAEKEIKKRDKSRAKYYKYYYGIDWGDPSN 158

                        170       180       190
                 ....*....|....*....|....*....|
gi 506390809 149 YDAAYNTARWGPERFIDVLVATIDAYDPAT 178
Cdd:COG1102  159 YDLVINTSRLGIEEAVDLILAAIEAREKKE 188
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 3-148 3.54e-38

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 128.37  E-value: 3.54e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   3 ITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIfremaaeRDMtpvEFNEFAEED---PQIDRDLDRRLHEIATtRDDLVL 79
Cdd:cd02020    2 IAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGI-------RTE---EVGKLASEVaaiPEVRKALDERQRELAK-KPGIVL 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 506390809  80 ESRLAGWLSADHADFRFWFDAPVSTRAERIAE-----REEKPVDRAKAETERREASEKKRYREYYDIDIGDLSI 148
Cdd:cd02020   71 EGRDIGTVVFPDADLKIFLTASPEVRAKRRAKqlqakGEGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVI 144
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 3-157 5.96e-17

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 74.59  E-value: 5.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    3 ITVSGPPGSGKSTNAAGLADRLGLDHVSGgDIFREMAAERDMTPVEFnEFAEEDPQIDRDLDRRLHEIATTR-------- 74
Cdd:pfam13189   2 ITISRQYGSGGTTIAKKLAEKLGYPFYDR-EILDEIAKELGISEEEF-ELFDEKSRLSSFLYSLAGGRVRGDalsddrlf 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   75 -------------DDLVLESRLAGWLSADHAD-FRFWFDAPVSTRAERIAEREEKPVDRAKAETERREASEKKRYREYYD 140
Cdd:pfam13189  80 daqskvirelaaeDNCVIVGRGADYILKDIPNvLRVFLTAPLEDRVKRVMEREGLSEEEARELIKETDKRRAKYYKYYTG 159

                         170
                  ....*....|....*..
gi 506390809  141 IDIGDLSIYDAAYNTAR 157
Cdd:pfam13189 160 KDWGDAENYDLVINTSK 176
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 3-69 3.34e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.58  E-value: 3.34e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506390809     3 ITVSGPPGSGKSTNAAGLADRLGLDH-----VSGGDIFREMAAERDMTPVEFNEFAEEDPQIDRDLDRRLHE 69
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGggviyIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARK 76
 
Name Accession Description Interval E-value
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-180 1.17e-100

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 287.86  E-value: 1.17e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAERDMTPVEFNEFAEEDPQIDRDLDRRLHEIATTRDDLVLE 80
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELAKERGMSLEEFNKYAEEDPEIDKEIDRRQLEIAEKEDNVVLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  81 SRLAGWLSADHADFRFWFDAPVSTRAERIAEREEKPVDRAKAETERREASEKKRYREYYDIDIGDLSIYDAAYNTARWGP 160
Cdd:PRK04182  81 GRLAGWMAKDYADLKIWLKAPLEVRAERIAEREGISVEEALEETIEREESEAKRYKEYYGIDIDDLSIYDLVINTSRWDP 160

                        170       180
                 ....*....|....*....|
gi 506390809 161 ERFIDVLVATIDAYDPATDE 180
Cdd:PRK04182 161 EGVFDIILTAIDKLLKAKDE 180
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1-172 9.83e-76

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 224.61  E-value: 9.83e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAERDMTPVEFNEFAEEDPQIDRDLDRRLHEIATTRDDLVLE 80
Cdd:TIGR02173   1 MIITISGPPGSGKTTVAKILAEKLSLKLISAGDIFRELAAKMGLDLIEFLNYAEENPEIDKKIDRRIHEIALKEKNVVLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   81 SRLAGWLSADHADFRFWFDAPVSTRAERIAEREEKPVDRAKAETERREASEKKRYREYYDIDIGDLSIYDAAYNTARWGP 160
Cdd:TIGR02173  81 SRLAGWIVREYADVKIWLKAPLEVRARRIAKREGKSLTVARSETIEREESEKRRYLKFYGIDIDDLSIYDLVINTSNWDP 160

                         170
                  ....*....|..
gi 506390809  161 ERfIDVLVATID 172
Cdd:TIGR02173 161 NN-VDIILDALD 171
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
1-178 9.39e-61

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 187.34  E-value: 9.39e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVsGGDIFREMAAERDMTPVEFNEFAEEDP-----------QIDRDLDRRLHE 69
Cdd:COG1102    1 MVITISREPGSGGTTIAKRLAEKLGLPLY-DGEILREAAKERGLSEEEFEKLDEKAPsllyrdtaeedEIDRALDKVIRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  70 IATtRDDLVLESRLAGWLSADH-ADFRFWFDAPVSTRAERIAEREEKPVDRAKAETERREASEKKRYREYYDIDIGDLSI 148
Cdd:COG1102   80 LAR-KGNCVIVGRLADWILRDRpNVLKVFLTAPLEVRVKRIAEREGISEEEAEKEIKKRDKSRAKYYKYYYGIDWGDPSN 158

                        170       180       190
                 ....*....|....*....|....*....|
gi 506390809 149 YDAAYNTARWGPERFIDVLVATIDAYDPAT 178
Cdd:COG1102  159 YDLVINTSRLGIEEAVDLILAAIEAREKKE 188
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 3-148 3.54e-38

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 128.37  E-value: 3.54e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   3 ITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIfremaaeRDMtpvEFNEFAEED---PQIDRDLDRRLHEIATtRDDLVL 79
Cdd:cd02020    2 IAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGI-------RTE---EVGKLASEVaaiPEVRKALDERQRELAK-KPGIVL 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 506390809  80 ESRLAGWLSADHADFRFWFDAPVSTRAERIAE-----REEKPVDRAKAETERREASEKKRYREYYDIDIGDLSI 148
Cdd:cd02020   71 EGRDIGTVVFPDADLKIFLTASPEVRAKRRAKqlqakGEGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVI 144
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 3-157 5.96e-17

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 74.59  E-value: 5.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    3 ITVSGPPGSGKSTNAAGLADRLGLDHVSGgDIFREMAAERDMTPVEFnEFAEEDPQIDRDLDRRLHEIATTR-------- 74
Cdd:pfam13189   2 ITISRQYGSGGTTIAKKLAEKLGYPFYDR-EILDEIAKELGISEEEF-ELFDEKSRLSSFLYSLAGGRVRGDalsddrlf 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   75 -------------DDLVLESRLAGWLSADHAD-FRFWFDAPVSTRAERIAEREEKPVDRAKAETERREASEKKRYREYYD 140
Cdd:pfam13189  80 daqskvirelaaeDNCVIVGRGADYILKDIPNvLRVFLTAPLEDRVKRVMEREGLSEEEARELIKETDKRRAKYYKYYTG 159

                         170
                  ....*....|....*..
gi 506390809  141 IDIGDLSIYDAAYNTAR 157
Cdd:pfam13189 160 KDWGDAENYDLVINTSK 176
AAA_17 pfam13207
AAA domain;
6-124 1.72e-13

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 64.18  E-value: 1.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    6 SGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAERDMTPvEFNEFAEEDPQIDRDLDRRL-HEIA--TTRDDLVLESR 82
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERGLVE-DRDEMRKLPLEPQKELQKLAaERIAeeAGEGGVIVDGH 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 506390809   83 LAGWLSAD-------------HADFRFWFDAPVSTRAERIAEREEKPVDRAKAET 124
Cdd:pfam13207  80 PRIKTPAGylpglpvevlrelKPDAIILLEADPEEILERRLKDRTRGRDDDSEEE 134
AAA_18 pfam13238
AAA domain;
3-127 6.90e-11

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 57.05  E-value: 6.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    3 ITVSGPPGSGKSTNAAGLADRLGLdhvsgGDIFREMAAERDMTPVEFNEFAEEDPqIDRDLDRRLHEIA------TTRDD 76
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-----GDNVRDLALENGLVLGDDPETRESKR-LDEDKLDRLLDLLeenaalEEGGN 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 506390809   77 LVLESRLAGWLSADHAD-FRFWFDAPVSTRAERIAEREEKPVDRAKAETERR 127
Cdd:pfam13238  75 LIIDGHLAELEPERAKDlVGIVLRASPEELLERLEKRGYEEAKIKENEEAEI 126
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 1-137 8.28e-10

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 54.62  E-value: 8.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    1 MLITVsGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAERDMTPVEFNEFAEedpqidrDLDRRLHEIATTR----DD 76
Cdd:pfam13671   1 LILLV-GLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSISYYTDATD-------RTYERLHELARIAlragRP 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 506390809   77 LVL------ESRLAGWLS-ADHADFRF---WFDAPVSTRAERIAEREEKPVDRAKAETERREAsEKKRYRE 137
Cdd:pfam13671  73 VILdatnlrRDERARLLAlAREYGVPVrivVFEAPEEVLRERLAARARAGGDPSDVPEEVLDR-QKARFEP 142
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 3-37 8.41e-09

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 53.01  E-value: 8.41e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 506390809   3 ITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFRE 37
Cdd:cd01428    2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLRE 36
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 7-41 3.29e-08

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 51.28  E-value: 3.29e-08
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 506390809   7 GPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAE 41
Cdd:COG0563    7 GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKA 41
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 7-37 6.00e-08

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 50.70  E-value: 6.00e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 506390809    7 GPPGSGKSTNAAGLADRLGLDHVSGGDIFRE 37
Cdd:TIGR01351   6 GPPGSGKGTQAKRIAEKYGLPHISTGDLLRA 36
adk PRK02496
adenylate kinase; Provisional
 7-47 1.05e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 49.75  E-value: 1.05e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 506390809   7 GPPGSGKSTNAAGLADRLGLDHVSGGDIFRemAAERDMTPV 47
Cdd:PRK02496   8 GPPGAGKGTQAVVLAEHLHIPHISTGDILR--QAIKEQTPL 46
adk PRK00279
adenylate kinase; Reviewed
 1-47 1.29e-07

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 49.76  E-value: 1.29e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFRemAAERDMTPV 47
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLR--AAVKAGTEL 45
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 7-148 2.41e-07

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 48.32  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   7 GPPGSGKSTNAAGLADRLGLDHVsggDIFREMAAERDMTPVEFneFAEEDPQIDRDLDRRLHEIATTRDDLVL------- 79
Cdd:cd00464    6 GMMGAGKTTVGRLLAKALGLPFV---DLDELIEQRAGMSIPEI--FAEEGEEGFRELEREVLLLLLTKENAVIatgggav 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 506390809  80 ESRLAGWLSADHAdFRFWFDAPVSTRAERIAEREEKPV--DRAKAETERREASEKKRYREYYD--IDIGDLSI 148
Cdd:cd00464   81 LREENRRLLLENG-IVVWLDASPEELLERLARDKTRPLlqDEDPERLRELLEEREPLYREVADltIDTDELSP 152
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
2-118 1.33e-06

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 46.06  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   2 LITVSGPPGSGKSTNAAGLADRLGLDHVSgGDIFREMAAERDMTPVEfnEFAEEDPQIDRDLDRRLHEIATTRDDLVLES 81
Cdd:COG0645    1 LILVCGLPGSGKSTLARALAERLGAVRLR-SDVVRKRLFGAGLAPLE--RSPEATARTYARLLALARELLAAGRSVILDA 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 506390809  82 ---------RLAGWLSADHADFRF-WFDAPVSTRAERIAEREEKPVD 118
Cdd:COG0645   78 tflrraqreAFRALAEEAGAPFVLiWLDAPEEVLRERLEARNAEGGD 124
ADK pfam00406
Adenylate kinase;
5-41 1.35e-06

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 46.53  E-value: 1.35e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 506390809    5 VSGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAE 41
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKS 37
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 5-138 5.56e-06

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 44.67  E-value: 5.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    5 VSGPPGSGKSTNAAGLADRLGLDHVSGGDIFREmaaERDMTPVEFNEFAEEdpQIDRD-----------LDRRLHEIATT 73
Cdd:TIGR01359   4 VLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRA---EIKREGSENGSLIES--YIKEGkivpsevtvelLKKAIQEDGSS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 506390809   74 RDDLV-----LESRLAGW--LSADHADFRF--WFDAPVSTRAERIAEREEkpvdrAKAETERREASEKKRYREY 138
Cdd:TIGR01359  79 KKFLIdgfprNEENLEAWekLMDNKVNFKFvlFFDCPEETMIKRLLKRGQ-----TSGRVDDNIETLKKRFRTY 147
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
1-90 7.04e-06

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 44.42  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFRemaaerdmtpvEFNEFAEEDPQ-----IDRD-LDRRLHEIatTR 74
Cdd:COG1936    1 MRIAITGTPGTGKTTVAKLLAERLGLEVIHLNDLVK-----------EEGLYTEVDEErdslvVDEDaLAEELEEL--KE 67

                         90
                 ....*....|....*.
gi 506390809  75 DDLVLESRLAGWLSAD 90
Cdd:COG1936   68 GDVIIEGHLAHLVDVD 83
aroK PRK00131
shikimate kinase; Reviewed
 1-152 9.72e-06

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 44.02  E-value: 9.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVsggDIFREMAAERDMTPVEFneFAEEDPQIDRDLDRRLHEIATTRDDLVL- 79
Cdd:PRK00131   5 PNIVLIGFMGAGKSTIGRLLAKRLGYDFI---DTDHLIEARAGKSIPEI--FEEEGEAAFRELEEEVLAELLARHNLVIs 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  80 ---------ESRlaGWLSADHadFRFWFDAPVSTRAERIAEREEKP---VDRAKAE-----TERReasekKRYREYYD-- 140
Cdd:PRK00131  80 tgggavlreENR--ALLRERG--TVVYLDASFEELLRRLRRDRNRPllqTNDPKEKlrdlyEERD-----PLYEEVADit 150

                        170
                 ....*....|..
gi 506390809 141 IDIGDLSIYDAA 152
Cdd:PRK00131 151 VETDGRSPEEVV 162
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 2-113 1.14e-05

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 43.40  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   2 LITVSGPPGSGKSTNAAGLADRLGLDHVSgGDIFREMAAERDMtpvefnefAEEDPQIDRDLDRRLHEIATTRDDLVLES 81
Cdd:cd02021    1 IIVVMGVSGSGKSTVGKALAERLGAPFID-GDDLHPPANIAKM--------AAGIPLNDEDRWPWLQALTDALLAKLASA 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 506390809  82 RLAG-------------WLSADHADFRFWF---DAPVSTRAERIAERE 113
Cdd:cd02021   72 GEGVvvacsalkriyrdILRGGAANPRVRFvhlDGPREVLAERLAARK 119
PRK14531 PRK14531
adenylate kinase; Provisional
 7-44 1.36e-05

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 43.65  E-value: 1.36e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 506390809   7 GPPGSGKSTNAAGLADRLGLDHVSGGDIFR-EMAAERDM 44
Cdd:PRK14531   9 GPPGAGKGTQAARLCAAHGLRHLSTGDLLRsEVAAGSAL 47
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 2-172 2.73e-05

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 42.88  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    2 LITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFR-EMAAERDMTP-----VEFNEFAEEDPQIDRDLDRRLHEIATTRD 75
Cdd:TIGR01360   5 IIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRaEVASGSERGKqlqaiMESGDLVPLDTVLDLLKDAMVAALGTSKG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   76 DLV------------LESRLAgwlsadHADFRFWFDAPVSTRAERIAEREEkpvdrAKAETERREASEKKRYREYYDIDI 143
Cdd:TIGR01360  85 FLIdgyprevkqgeeFERRIG------PPTLVLYFDCSEDTMVKRLLKRAE-----TSGRVDDNEKTIKKRLETYYKATE 153

                         170       180       190
                  ....*....|....*....|....*....|...
gi 506390809  144 GDLSIYDAAYNTARWGPERFID----VLVATID 172
Cdd:TIGR01360 154 PVIAYYETKGKLRKINAEGTVDdvflQVCTAID 186
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 3-134 3.90e-05

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 42.68  E-value: 3.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    3 ITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMA-----AERDMT------------PVEFNEF----AEED----- 56
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALAlaalrQKVDLTdedalaelasevDISFGHTevflNGEDvssei 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   57 ---------------PQIDRDLDRRLHEIATTrDDLVLESRLAGWLSADHADFRFWFDAPVSTRAE-RIAEREEKPVDRA 120
Cdd:pfam02224  81 rtdevaqaasqvaaiPAVRARLNKLQRQLAKN-GNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKrRYKQLQAKGLSVD 159

                         170
                  ....*....|....*...
gi 506390809  121 KAETE----RREASEKKR 134
Cdd:pfam02224 160 FEELLaeikRRDKRDSER 177
PRK14526 PRK14526
adenylate kinase; Provisional
 1-37 1.28e-04

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 40.99  E-value: 1.28e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFRE 37
Cdd:PRK14526   1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRE 37
PRK14527 PRK14527
adenylate kinase; Provisional
 7-40 1.63e-04

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 40.54  E-value: 1.63e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 506390809   7 GPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAA 40
Cdd:PRK14527  13 GPPGAGKGTQAERLAQELGLKKLSTGDILRDHVA 46
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 1-176 2.59e-04

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 40.33  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRL---GLDHV--------SGGDIFREM---AAERDMTPV-EFNEFAeedpqidrdLDR 65
Cdd:cd01672    1 MFIVFEGIDGAGKTTLIELLAERLearGYEVVltrepggtPIGEAIRELlldPEDEKMDPRaELLLFA---------ADR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  66 RLH--EI---ATTRDDLVL-----ESRLAG-------------WLSADH-----ADFRFWFDAPVSTRAERIAEReekpv 117
Cdd:cd01672   72 AQHveEVikpALARGKIVLsdrfvDSSLAYqgagrglgealieALNDLAtgglkPDLTILLDIDPEVGLARIEAR----- 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 506390809 118 dRAKAETERREASEKKRYREYYdidigdlsiydaaYNTARWGPERFIdvlvaTIDAYDP 176
Cdd:cd01672  147 -GRDDRDEQEGLEFHERVREGY-------------LELAAQEPERII-----VIDASQP 186
PRK14530 PRK14530
adenylate kinase; Provisional
 3-57 2.80e-04

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 40.16  E-value: 2.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 506390809   3 ITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFR--------EMAAERDmTPVEFNEFAEEDP 57
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRankqmdisDMDTEYD-TPGEYMDAGELVP 67
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 7-152 2.88e-04

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 39.73  E-value: 2.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   7 GPPGSGKSTNAAGLADRLGLDHVsggDIFREMAAERDMTPVEFneFAEEDPQIDRDLDRRLHEIATTRDDLVL------- 79
Cdd:COG0703    5 GMMGAGKSTVGRLLAKRLGLPFV---DTDAEIEERAGMSIPEI--FAEEGEAGFRELEREVLAELLEEENAVIatgggav 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  80 ---ESRlaGWLSAdhADFRFWFDAPVSTRAERIAEREEKPV---DRAKAETERREASEKKRYREYYD--IDIGDLSIYDA 151
Cdd:COG0703   80 lspENR--ELLKE--HGTVVYLDASPETLLERLRRDDNRPLlqgEDPRERLEELLAEREPLYREVADitVDTDGRSPEEV 155


                 .
gi 506390809 152 A 152
Cdd:COG0703  156 V 156
PRK13808 PRK13808
adenylate kinase; Provisional
 1-47 4.89e-04

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 39.87  E-value: 4.89e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFRemAAERDMTPV 47
Cdd:PRK13808   1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLR--AAVAAGTPV 45
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
1-112 6.59e-04

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 38.77  E-value: 6.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKStNAAGLADRLGLDHVSGGDIFREMAAERDM--TPVEFNEFAEEDPQ---IDRDLDRRLHEIATTRD 75
Cdd:PRK01184   2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREEVKKRGLepTDENIGKVAIDLRKelgMDAVAKRTVPKIREKGD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 506390809  76 DLVLESRLAGwlSADHADFRFWFD---------APVSTRAERIAER 112
Cdd:PRK01184  81 EVVVIDGVRG--DAEVEYFRKEFPedfiliaihAPPEVRFERLKKR 124
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 1-115 6.60e-04

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 38.94  E-value: 6.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLD-----HVSGGDIFREMAAERDMTPVeFNEFAEE--DPQIDRDLDRRLHEIAtt 73
Cdd:COG4088    5 MLLILTGPPGSGKTTFAKALAQRLYAEgiavaLLHSDDFRRFLVNESFPKET-YEEVVEDvrTTTADNALDNGYSVIV-- 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 506390809  74 rDDLVLESRLAG---WLSADHADFRF-WFDAPVSTRAERIAEREEK 115
Cdd:COG4088   82 -DGTFYYRSWQRdfrNLAKHKAPIHIiYLKAPLETALRRNRERGEP 126
PRK14528 PRK14528
adenylate kinase; Provisional
 7-47 6.90e-04

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 38.84  E-value: 6.90e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 506390809   7 GPPGSGKSTNAAGLADRLGLDHVSGGDIFREmaAERDMTPV 47
Cdd:PRK14528   8 GPPGAGKGTQAKILCERLSIPQISTGDILRE--AVKNQTAM 46
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 3-58 9.76e-04

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 38.36  E-value: 9.76e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 506390809   3 ITVSGPPGSGKSTNAAGLADRLGLDHVsggdifremaAERDMTPVEFNEFAE---EDPQ 58
Cdd:cd01673    2 IVVEGNIGAGKSTLAKELAEHLGYEVV----------PEPVEPDVEGNPFLEkfyEDPK 50
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
1-36 1.04e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 38.47  E-value: 1.04e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFR 36
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYR 36
PRK14529 PRK14529
adenylate kinase; Provisional
 1-37 1.12e-03

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 38.55  E-value: 1.12e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFRE 37
Cdd:PRK14529   1 MNILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFRE 37
PLN02842 PLN02842
nucleotide kinase
 5-44 1.60e-03

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 38.30  E-value: 1.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 506390809   5 VSGPPGSGKSTNAAGLADRLGLDHVSGGDIFR-EMAAERDM 44
Cdd:PLN02842   2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRaEVSAGTDI 42
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
 1-140 1.77e-03

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 37.62  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSGGD----IFREMAAERD--------------MTPVEFNEFAEED-----P 57
Cdd:COG2074    7 RIILIGGASGVGKSTIAAELARRLGIPRVISTDsireVMRPIISKELvptlhtssyeayksLSEEEIIAGFLDQaeavsP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  58 QIDRDLDRRLHEiattRDDLVLES------RLAGWLSADHADFRF-WFDAPVSTRAERIAEREEKPvdrAKAETERREAS 130
Cdd:COG2074   87 GIEAVIERALKE----GESLVIEGvhlvpgFLAELKFNGGNVVMLvLLVSDEELHRERFYSRARYT---HANRPGERYLD 159

                        170
                 ....*....|
gi 506390809 131 EKKRYREYYD 140
Cdd:COG2074  160 HFERIRRIQD 169
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 1-113 2.16e-03

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 37.03  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLdHVSGGDIF------REMAAErdmTPvefneFAEED--PQIDRdLDRRLHEIAT 72
Cdd:COG3265    2 MVIVVMGVSGSGKSTVGQALAERLGW-PFIDGDDFhppaniAKMAAG---IP-----LTDEDraPWLEA-LADAIAAHLA 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 506390809  73 TRDDLV-----LESRLAGWLSADHADFRF-WFDAPVSTRAERIAERE 113
Cdd:COG3265   72 AGEGAVlacsaLKRSYRDRLREGNPDVRFvYLDGSRELIAERLAARK 118
PRK03839 PRK03839
putative kinase; Provisional
 1-90 2.90e-03

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 37.01  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHVSggdiFREMAAERDMtpvefNEFAEEDPQIDRDLDRRLHEIATTRDDLVLE 80
Cdd:PRK03839   1 MIIAITGTPGVGKTTVSKLLAEKLGYEYVD----LTEFALKKGI-----GEEKDDEMEIDFDKLAYFIEEEFKEKNVVLD 71

                         90
                 ....*....|
gi 506390809  81 SRLAGWLSAD 90
Cdd:PRK03839  72 GHLSHLLPVD 81
PLN02459 PLN02459
probable adenylate kinase
 7-37 3.18e-03

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 37.13  E-value: 3.18e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 506390809   7 GPPGSGKSTNAAGLADRLGLDHVSGGDIFRE 37
Cdd:PLN02459  36 GCPGVGKGTYASRLSKLLGVPHIATGDLVRE 66
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 1-141 3.26e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 37.13  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRLGLDHV---SGGDIFREmaaeRDMTPVEFN-------------EFAEED-------- 56
Cdd:COG0572    8 RIIGIAGPSGSGKTTFARRLAEQLGADKVvviSLDDYYKD----REHLPLDERgkpnfdhpeafdlDLLNEHleplkage 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809  57 ----PQIDRDLDRRLHEIATTRDD--LVLESRLAGW--LSADHADFRFWFDAPVSTRAER-----IAEREEKPVDRAKAE 123
Cdd:COG0572   84 svelPVYDFATGTRSGETVKVEPAdvIIVEGIHALNdeLLRDLLDLKIYVDADTDVRLIRrivrdGEERGRTAESVIEQY 163

                        170       180
                 ....*....|....*....|.
gi 506390809 124 TERREASEKK---RYREYYDI 141
Cdd:COG0572  164 WATVRPGHEQyiePTKEYADI 184
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 3-69 3.34e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.58  E-value: 3.34e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506390809     3 ITVSGPPGSGKSTNAAGLADRLGLDH-----VSGGDIFREMAAERDMTPVEFNEFAEEDPQIDRDLDRRLHE 69
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGggviyIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARK 76
PRK13764 PRK13764
ATPase; Provisional
 3-44 3.79e-03

ATPase; Provisional


Pssm-ID: 184311 [Multi-domain]  Cd Length: 602  Bit Score: 37.51  E-value: 3.79e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 506390809   3 ITVSGPPGSGKSTNAAGLADRLgldhVSGGDIFREMAAERDM 44
Cdd:PRK13764 260 ILIAGAPGAGKSTFAQALAEFY----ADMGKIVKTMESPRDL 297
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
3-43 4.43e-03

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 37.33  E-value: 4.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 506390809   3 ITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFR--EMAAERD 43
Cdd:PRK11860 445 ICIDGPTASGKGTVAARVAEALGYHYLDSGALYRltALAALRA 487
SKI pfam01202
Shikimate kinase;
9-141 5.21e-03

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 36.02  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506390809    9 PGSGKSTNAAGLADRLGLDHVsggDIFREMAAERDMTPVEFneFAEEDPQIDRDLDRRLHEIATTRDDLVL-------ES 81
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFI---DTDEEIEKRTGMSIAEI--FEEEGEEGFRRLESEVLKELLAEHGLVIatgggavLS 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 506390809   82 RLAGWLSADHADFrFWFDAPVSTRAERIAEREEKPV----DRAKAETERREASEKKRYREYYDI 141
Cdd:pfam01202  76 EENRDLLKERGIV-IYLDAPLEVLLERLKRDKTRPLlqnkDPEEELLELLFEERDPLYEEAADI 138
Tmk COG0125
Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the ...
 1-24 6.65e-03

Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the Pathway/BioSystem: Thymidylate biosynthesis


Pssm-ID: 439895 [Multi-domain]  Cd Length: 206  Bit Score: 35.90  E-value: 6.65e-03
                         10        20
                 ....*....|....*....|....
gi 506390809   1 MLITVSGPPGSGKSTNAAGLADRL 24
Cdd:COG0125    4 KFIVFEGIDGSGKSTQIKLLAEYL 27
PLN02200 PLN02200
adenylate kinase family protein
 5-36 7.21e-03

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 36.02  E-value: 7.21e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 506390809   5 VSGPPGSGKSTNAAGLADRLGLDHVSGGDIFR 36
Cdd:PLN02200  48 VLGGPGSGKGTQCEKIVETFGFKHLSAGDLLR 79
NDUO42 cd02030
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar ...
 2-50 7.53e-03

NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.


Pssm-ID: 238988  Cd Length: 219  Bit Score: 35.79  E-value: 7.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 506390809   2 LITVSGPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAERDMTP--VEFN 50
Cdd:cd02030    1 VITVDGNIASGKGKLAKELAEKLGMKYFPEAGIHYLDSTTGDGKPldPAFN 51
PLN02674 PLN02674
adenylate kinase
 7-63 9.67e-03

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 35.63  E-value: 9.67e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 506390809   7 GPPGSGKSTNAAGLADRLGLDHVSGGDIFREMAAERDMTPVEFNEFAEEDPQIDRDL 63
Cdd:PLN02674  38 GPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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