|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
15-249 |
1.23e-151 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 421.92 E-value: 1.23e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 15 DESESTAILTGAGVSTASGIPDFRGPQGLYKKLPQYIFDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKKG 94
Cdd:PRK14138 9 NESRLTVTLTGAGISTPSGIPDFRGPQGIYKKYPQNVFDIDFFYSHPEEFYRFAKEGIFPMLEAKPNLAHVLLAKLEEKG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 95 MIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDVPKC-TCGGLIKPDVVFFGEALPESA 173
Cdd:PRK14138 89 LIEAVITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGKRYTVEDVIEKLEKSDVPRCdDCSGLIRPNIVFFGEALPQDA 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506348515 174 MAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYECDLAEFSERIISLLGEV 249
Cdd:PRK14138 169 LREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVIVNLGETPLDDIATLKYNMDVVEFANRVMSEGGIS 244
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
15-244 |
2.36e-110 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 317.49 E-value: 2.36e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 15 DESESTAILTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKK 93
Cdd:COG0846 12 REAKRIVVLTGAGISAESGIPDFRGPDGLWEKYdPEEVASPEAFRRDPELVWAFYNERRRLLRDAEPNAAHRALAELEKA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 94 GMIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDVPKCT-CGGLIKPDVVFFGEALPES 172
Cdd:COG0846 92 GKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEGELPPRCPkCGGLLRPDVVWFGEMLPEE 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506348515 173 AMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYECDLAEFSERIIS 244
Cdd:COG0846 172 ALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
15-232 |
1.48e-108 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 312.00 E-value: 1.48e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 15 DESESTAILTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKK 93
Cdd:cd01413 2 TKSRKTVVLTGAGISTESGIPDFRSPDGLWKKYdPEEVASIDYFYRNPEEFWRFYKEIILGLLEAQPNKAHYFLAELEKQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 94 GMIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMlEVSDVPKCT-CGGLIKPDVVFFGEALPES 172
Cdd:cd01413 82 GIIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEEVKYA-KKHEVPRCPkCGGIIRPDVVLFGEPLPQA 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 173 AMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYE 232
Cdd:cd01413 161 LLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETPFDYIADLVIQ 220
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
17-243 |
6.46e-104 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 301.03 E-value: 6.46e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 17 SESTAI-LTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKKG 94
Cdd:NF040867 9 SSRHAIaFTGAGISTESGIPTFRGPDGLWRRYdPEELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYALAELERMG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 95 MIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVS-DVPKCT-CGGLIKPDVVFFGEALPES 172
Cdd:NF040867 89 ILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRKIDKGeLPPRCPeCGGLLRPDVVLFGEPLPDD 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 506348515 173 AMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYECDLAEFSERII 243
Cdd:NF040867 169 ALEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKENGGKLIIINPEETPLDPIADIVLRGRAGEVLPKLV 239
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
25-198 |
5.96e-75 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 225.21 E-value: 5.96e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 25 GAGVSTASGIPDFRGPQGLYKKL-------PQYIFDLDFFLSQPAEYYKIAADRIhnLFNKEPNATHRLLAMLEKKGMIE 97
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLapeelasPEAFFSNPELVWDPEPFYNIARELL--PGEAQPNPAHYFIAKLEDKGKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 98 GVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDVPKC-TCGGLIKPDVVFFGEALPEsAMAE 176
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYERIRPEKVPHCpQCGGLLKPDIVFFGENLPD-KFHR 157
|
170 180
....*....|....*....|..
gi 506348515 177 AYILSENAELFITMGSSLVVYP 198
Cdd:pfam02146 158 AYEDLEEADLLIVIGTSLKVYP 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
15-249 |
1.23e-151 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 421.92 E-value: 1.23e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 15 DESESTAILTGAGVSTASGIPDFRGPQGLYKKLPQYIFDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKKG 94
Cdd:PRK14138 9 NESRLTVTLTGAGISTPSGIPDFRGPQGIYKKYPQNVFDIDFFYSHPEEFYRFAKEGIFPMLEAKPNLAHVLLAKLEEKG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 95 MIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDVPKC-TCGGLIKPDVVFFGEALPESA 173
Cdd:PRK14138 89 LIEAVITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGKRYTVEDVIEKLEKSDVPRCdDCSGLIRPNIVFFGEALPQDA 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506348515 174 MAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYECDLAEFSERIISLLGEV 249
Cdd:PRK14138 169 LREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVIVNLGETPLDDIATLKYNMDVVEFANRVMSEGGIS 244
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
15-244 |
2.36e-110 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 317.49 E-value: 2.36e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 15 DESESTAILTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKK 93
Cdd:COG0846 12 REAKRIVVLTGAGISAESGIPDFRGPDGLWEKYdPEEVASPEAFRRDPELVWAFYNERRRLLRDAEPNAAHRALAELEKA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 94 GMIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDVPKCT-CGGLIKPDVVFFGEALPES 172
Cdd:COG0846 92 GKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEGELPPRCPkCGGLLRPDVVWFGEMLPEE 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506348515 173 AMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYECDLAEFSERIIS 244
Cdd:COG0846 172 ALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
15-232 |
1.48e-108 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 312.00 E-value: 1.48e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 15 DESESTAILTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKK 93
Cdd:cd01413 2 TKSRKTVVLTGAGISTESGIPDFRSPDGLWKKYdPEEVASIDYFYRNPEEFWRFYKEIILGLLEAQPNKAHYFLAELEKQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 94 GMIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMlEVSDVPKCT-CGGLIKPDVVFFGEALPES 172
Cdd:cd01413 82 GIIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEEVKYA-KKHEVPRCPkCGGIIRPDVVLFGEPLPQA 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 173 AMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYE 232
Cdd:cd01413 161 LLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETPFDYIADLVIQ 220
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
17-243 |
6.46e-104 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 301.03 E-value: 6.46e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 17 SESTAI-LTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKKG 94
Cdd:NF040867 9 SSRHAIaFTGAGISTESGIPTFRGPDGLWRRYdPEELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYALAELERMG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 95 MIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVS-DVPKCT-CGGLIKPDVVFFGEALPES 172
Cdd:NF040867 89 ILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRKIDKGeLPPRCPeCGGLLRPDVVLFGEPLPDD 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 506348515 173 AMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYECDLAEFSERII 243
Cdd:NF040867 169 ALEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKENGGKLIIINPEETPLDPIADIVLRGRAGEVLPKLV 239
|
|
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
15-246 |
1.47e-101 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 295.16 E-value: 1.47e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 15 DESESTAILTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKK 93
Cdd:PRK00481 11 DKAKRIVVLTGAGISAESGIPDFRSANGLWEEHrPEDVASPEGFARDPELVWKFYNERRRQLLDAKPNAAHRALAELEKL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 94 GMIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKmlevSDVPKCT-CGGLIKPDVVFFGEALPES 172
Cdd:PRK00481 91 GKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLK----PEPPRCPkCGGILRPDVVLFGEMLPEL 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 506348515 173 AMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYECDLAEFSERIISLL 246
Cdd:PRK00481 167 AIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVEEL 240
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
21-228 |
2.46e-101 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 293.71 E-value: 2.46e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 21 AILTGAGVSTASGIPDFRGPQGLYKKLPQYI--FDLDFFLSQPAEYYKIAADRiHNLFNKEPNATHRLLAMLEKKGMIEG 98
Cdd:cd01407 4 VVLTGAGISTESGIPDFRSPGGLWARLDPEElaFSPEAFRRDPELFWGFYRER-RYPLNAQPNPAHRALAELERKGKLKR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 99 VITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDVPKCT-CGGLIKPDVVFFGEALPESAMAEA 177
Cdd:cd01407 83 VITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQADIDREEVPRCPkCGGLLRPDVVFFGESLPEELDEAA 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 506348515 178 YILSEnAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIAD 228
Cdd:cd01407 163 EALAK-ADLLLVIGTSLQVYPAAGLPLYAPERGAPVVIINLEPTPADRKAD 212
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
21-224 |
6.36e-84 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 249.57 E-value: 6.36e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 21 AILTGAGVSTASGIPDFRGPQ-GLYKKLPQYI--FDLDFFLSQPAEYYKIAADRIHNLFNKEPNATHRLLAMLEKKGMIE 97
Cdd:cd00296 4 VVFTGAGISTESGIPDFRGLGtGLWTRLDPEElaFSPEAFRRDPELFWLFYKERRYTPLDAKPNPAHRALAELERKGKLK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 98 GVITQNIDGLHQKAGSK--KVIELHGNAQKFFCMSCGKRYTAEDvlkMLEVSDVPKCT-CGGLIKPDVVFFGEALPESAM 174
Cdd:cd00296 84 RIITQNVDGLHERAGSRrnRVIELHGSLDRVRCTSCGKEYPRDE---VLEREKPPRCPkCGGLLRPDVVDFGEALPKEWF 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 506348515 175 AEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLD 224
Cdd:cd00296 161 DRALEALLEADLVLVIGTSLTVYPAARLLLRAPERGAPVVIINREPTPAD 210
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
25-198 |
5.96e-75 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 225.21 E-value: 5.96e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 25 GAGVSTASGIPDFRGPQGLYKKL-------PQYIFDLDFFLSQPAEYYKIAADRIhnLFNKEPNATHRLLAMLEKKGMIE 97
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLapeelasPEAFFSNPELVWDPEPFYNIARELL--PGEAQPNPAHYFIAKLEDKGKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 98 GVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDVPKC-TCGGLIKPDVVFFGEALPEsAMAE 176
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYERIRPEKVPHCpQCGGLLKPDIVFFGENLPD-KFHR 157
|
170 180
....*....|....*....|..
gi 506348515 177 AYILSENAELFITMGSSLVVYP 198
Cdd:pfam02146 158 AYEDLEEADLLIVIGTSLKVYP 179
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
21-228 |
4.36e-69 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 212.06 E-value: 4.36e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 21 AILTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPA---EYYKIaadRIHNLFNKEPNATHRLLAMLEKKGMI 96
Cdd:cd01412 4 VVLTGAGISAESGIPTFRDADGLWARFdPEELATPEAFARDPElvwEFYNW---RRRKALRAQPNPAHLALAELERRLPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 97 EGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGkrYTAEDVLKMLEvSDVPKC-TCGGLIKPDVVFFGEALPESAMA 175
Cdd:cd01412 81 VLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCG--YVGENNEEIPE-EELPRCpKCGGLLRPGVVWFGESLPLALLE 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 506348515 176 EAYILSEnAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIAD 228
Cdd:cd01412 158 AVEALAK-ADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIAD 209
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
23-228 |
5.46e-69 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 211.84 E-value: 5.46e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 23 LTGAGVSTASGIPDFRGPQGLYKKL----PQYIFDLDFFLSQPAEYYKIAADRIhNLFNKEPNATHRLLAMLEKKGMIeG 98
Cdd:cd01411 14 FTGAGVSTASGIPDYRSKNGLYNEIykysPEYLLSHDFLEREPEKFYQFVKENL-YFPDAKPNIIHQKMAELEKMGLK-A 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 99 VITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKmlevsdVPKCT-CGGLIKPDVVFFGEALPESAMAEA 177
Cdd:cd01411 92 VITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVDWEEYLK------SPYHAkCGGVIRPDIVLYEEMLNESVIEEA 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 506348515 178 YILSENAELFITMGSSLVVYPAAHLPTFaKQKGAKLLIINQGETGLDYIAD 228
Cdd:cd01411 166 IQAIEKADLLVIVGTSFVVYPFAGLIDY-RQAGANLIAINKEPTQLDSPAT 215
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
18-230 |
1.89e-68 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 209.85 E-value: 1.89e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 18 ESTAILTGAGVSTASGIPDFRGPQGLYKKLPQYifdldfflsqpaeyyKIAADRIHNLFNKEPNATHRLLAMLEKKGMIE 97
Cdd:cd01410 1 KHLVVFTGAGISTSAGIPDFRGPNGVWTLLPED---------------KGRRRFSWRFRRAEPTLTHMALVELERAGLLK 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 98 GVITQNIDGLHQKAG--SKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDV-PKCT-CGGLIKPDVVFFGEALPESA 173
Cdd:cd01410 66 FVISQNVDGLHLRSGlpREKLSELHGNMFIEVCKSCGPEYVRDDVVETRGDKETgRRCHaCGGILKDTIVDFGERLPPEN 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 506348515 174 MAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKK 230
Cdd:cd01410 146 WMGAAAAACRADLFLCLGTSLQVTPAANLPLKAARAGGRLVIVNLQPTPKDKLADLV 202
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
16-232 |
6.84e-59 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 187.12 E-value: 6.84e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 16 ESESTAILTGAGVSTASGIPDFRGPQGLYKKLPQYIFDLDFFLSQPAE----------YYKIAADRihnlfnkePNATHR 85
Cdd:cd01409 7 RSRRLLVLTGAGISTESGIPDYRSEGGLYSRTFRPMTHQEFMRSPAARqrywarsfvgWPRFSAAQ--------PNAAHR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 86 LLAMLEKKGMIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAE--------------DVLKMLEVSD--- 148
Cdd:cd01409 79 ALAALEAAGRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCGFRTPRAelqdrlealnpgfaEQAAGQAPDGdvd 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 149 ----------VPKCT-CGGLIKPDVVFFGEALPESAMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIIN 217
Cdd:cd01409 159 ledeqvagfrVPECErCGGVLKPDVVFFGENVPRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVLAAAEAGLPIAIVN 238
|
250
....*....|....*
gi 506348515 218 QGETGLDYIADKKYE 232
Cdd:cd01409 239 IGPTRADHLATLKVD 253
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
22-215 |
8.99e-59 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 185.91 E-value: 8.99e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 22 ILTGAGVSTASGIPDFRGP-QGLYKKL-------PQYIFDLDFFLSQPAEYYKIAadriHNLF--NKEPNATHRLLAMLE 91
Cdd:cd01408 5 VLVGAGISTSAGIPDFRSPgTGLYANLarynlpyPEAMFDISYFRKNPRPFYALA----KELYpgQFKPSVAHYFIKLLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 92 KKGMIEGVITQNIDGLHQKAG--SKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDVPKC-TCGGLIKPDVVFFGEA 168
Cdd:cd01408 81 DKGLLLRNYTQNIDTLERVAGvpDDRIIEAHGSFATAHCIKCKHKYPGDWMREDIFNQEVPKCpRCGGLVKPDIVFFGES 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 506348515 169 LPESAMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLI 215
Cdd:cd01408 161 LPSRFFSHMEEDKEEADLLIVIGTSLKVAPFASLPSRVPSEVPRVLI 207
|
|
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
22-237 |
4.36e-50 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 165.62 E-value: 4.36e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 22 ILTGAGVSTASGIPDFRGPQGLYKKLPQYIFDlDFFLSQPAE--YYKIAADRIHNLFNKEPNATHRLLAMLEKKGMIEGV 99
Cdd:PRK05333 24 VLTGAGISTDSGIPDYRDRNGQWKRSPPITYQ-AFMGSDAARrrYWARSMVGWPVFGRAQPNAAHHALARLGAAGRIERL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 100 ITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSD---------------------------VPKC 152
Cdd:PRK05333 103 VTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCGARHPRAEIQHVLEAANpewlaleaapapdgdadlewaafdhfrVPAC 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 153 -TCGGLIKPDVVFFGEALPESAMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKY 231
Cdd:PRK05333 183 pACGGILKPDVVFFGENVPRERVAAARAALDAADAVLVVGSSLMVYSGYRFCVWAAQQGKPIAALNLGRTRADPLLTLKV 262
|
....*.
gi 506348515 232 ECDLAE 237
Cdd:PRK05333 263 EASCAQ 268
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
23-240 |
4.80e-46 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 154.69 E-value: 4.80e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 23 LTGAGVSTASGIPDFRGPQ-GLYKKLPQYIFDLDF-FLSQPAEYYKIAADrIHNLFNKEPNATHRLLAMLEKKGMIEGVI 100
Cdd:PTZ00409 34 LTGSGTSAESNIPSFRGPSsSIWSKYDPKIYGTIWgFWKYPEKIWEVIRD-ISSDYEIELNPGHVALSTLESLGYLKFVV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 101 TQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYTAEDVlkMLEVSD------VPKCTCGGLIKPDVVFFGEALPESAM 174
Cdd:PTZ00409 113 TQNVDGLHEESGNTKVIPLHGSVFEARCCTCRKTIQLNKI--MLQKTShfmhqlPPECPCGGIFKPNVILFGEVIPKSLL 190
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506348515 175 AEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETGL-DYIADKKYEcdlAEFSE 240
Cdd:PTZ00409 191 KQAEKEIDKCDLLLVVGTSSSVSTATNLCYRAHRKKKKIVEVNISKTYItNRISDYHVR---AKFSE 254
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
21-222 |
5.24e-41 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 140.73 E-value: 5.24e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 21 AILTGAGVSTASGIPDFRGPQGLYKKLP-QYIFDLDFFLSQPAEYYKIAADRIHNLFNKE--PNATHRLLAMLEK--KGM 95
Cdd:PTZ00408 8 TILTGAGISAESGISTFRDGNGLWENHRvEDVATPDAFLRNPALVQRFYNERRRALLSSSvkPNKAHFALAKLEReyRGG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 96 IEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSCGKRYT-AEDVlkmleVSDVPKCTCGGL---IKPDVVFFGE-ALP 170
Cdd:PTZ00408 88 KVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDwTEDV-----VHGSSRCKCCGCvgtLRPHIVWFGEmPLY 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 506348515 171 esaMAEAYILSENAELFITMGSSLVVYPAAHLPTFAKQKGAKLLIINQGETG 222
Cdd:PTZ00408 163 ---MDEIESVMSKTDLFVAVGTSGNVYPAAGFVGRAQFYGATTLELNLEEGT 211
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
22-203 |
1.03e-37 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 135.00 E-value: 1.03e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 22 ILTGAGVSTASGIPDFRGPQ-GLYKKLPQY-------IFDLDFFLSQPAEYYKIAADRihNLF--NKEPNATHRLLAMLE 91
Cdd:PTZ00410 34 VMVGAGISVAAGIPDFRSPHtGIYAKLGKYnlnsptdAFSLTLLREKPEVFYSIAREM--DLWpgHFQPTAVHHFIRLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 92 KKGMIEGVITQNIDGLHQKAG--SKKVIELHGNAQKFFCMSCGKRYTAEDVLKMLEVSDVPKC-TCGGLIKPDVVFFGEA 168
Cdd:PTZ00410 112 DEGRLLRCCTQNIDGLERAAGvpPSLLVEAHGSFSAASCIECHTPYDIEQAYLEARSGKVPHCsTCGGIVKPDVVFFGEN 191
|
170 180 190
....*....|....*....|....*....|....*
gi 506348515 169 LPEsAMAEAYILSENAELFITMGSSLVVYPAAHLP 203
Cdd:PTZ00410 192 LPD-AFFNVHHDIPEAELLLIIGTSLQVHPFALLA 225
|
|
| SIR2-like |
cd01406 |
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key ... |
21-105 |
5.67e-04 |
|
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.
Pssm-ID: 238697 [Multi-domain] Cd Length: 242 Bit Score: 40.08 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506348515 21 AILTGAGVSTASGIPDFRgpqGLYKKLPQYIFDLDFFLSQPAE----YYKIA--------------ADRIHNLFNK--EP 80
Cdd:cd01406 4 VIFVGAGVSVSSGLPDWK---TLLDEIASELGLEIDGYSVEAKdendYLELAellekefgtigikiNAVLEEKTRPdfEP 80
|
90 100
....*....|....*....|....*.
gi 506348515 81 NATHRLLAMLEKKG-MIEGVITQNID 105
Cdd:cd01406 81 SPLHELLLRLFINNeGDVIIITTNYD 106
|
|
| |
