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Conserved domains on  [gi|506315561|ref|WP_015835336|]
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MULTISPECIES: shikimate kinase AroL [Photorhabdus]

Protein Classification

shikimate kinase( domain architecture ID 10792322)

shikimate kinase catalyzes the specific phosphorylation of the 3-hydroxylgroup of shikimic acid using ATP as a cosubstrate

EC:  2.7.1.71

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aroL PRK03731
shikimate kinase AroL;
1-171 4.72e-111

shikimate kinase AroL;


:

Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 313.03  E-value: 4.72e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   1 MNPILFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQKNRVISTGGG 80
Cdd:PRK03731   1 MTQPLFLVGARGCGKTTVGMALAQALGYRFVDTDQWLQSTSNMTVAEIVEREGWAGFRARESAALEAVTAPSTVIATGGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  81 IILSAENRQYMQQNGMVIYLQASADILAERLMQHPENTQRPSLTGKSIVEEMEEVLAAREKLYCECANHIINAQLSPEKI 160
Cdd:PRK03731  81 IILTEENRHFMRNNGIVIYLCAPVSVLANRLEANPEEDQRPTLTGKPISEEVAEVLAEREALYREVAHHIIDATQPPSQV 160

                        170
                 ....*....|.
gi 506315561 161 TTCVKEIILSR 171
Cdd:PRK03731 161 VSEILSALAQS 171
 
Name Accession Description Interval E-value
aroL PRK03731
shikimate kinase AroL;
1-171 4.72e-111

shikimate kinase AroL;


Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 313.03  E-value: 4.72e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   1 MNPILFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQKNRVISTGGG 80
Cdd:PRK03731   1 MTQPLFLVGARGCGKTTVGMALAQALGYRFVDTDQWLQSTSNMTVAEIVEREGWAGFRARESAALEAVTAPSTVIATGGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  81 IILSAENRQYMQQNGMVIYLQASADILAERLMQHPENTQRPSLTGKSIVEEMEEVLAAREKLYCECANHIINAQLSPEKI 160
Cdd:PRK03731  81 IILTEENRHFMRNNGIVIYLCAPVSVLANRLEANPEEDQRPTLTGKPISEEVAEVLAEREALYREVAHHIIDATQPPSQV 160

                        170
                 ....*....|.
gi 506315561 161 TTCVKEIILSR 171
Cdd:PRK03731 161 VSEILSALAQS 171
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 5-168 2.69e-66

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 199.58  E-value: 2.69e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   5 LFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQK-NRVISTGGGIIL 83
Cdd:COG0703    1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEeNAVIATGGGAVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  84 SAENRQYMQQNGMVIYLQASADILAERLMQhpeNTQRPSLTGKSIVEEMEEVLAAREKLYCECANHIINA-QLSPEKItt 162
Cdd:COG0703   81 SPENRELLKEHGTVVYLDASPETLLERLRR---DDNRPLLQGEDPRERLEELLAEREPLYREVADITVDTdGRSPEEV-- 155


                 ....*.
gi 506315561 163 cVKEII 168
Cdd:COG0703  156 -VDEIL 160
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 4-158 1.27e-63

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 192.77  E-value: 1.27e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   4 ILFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVS-QKNRVISTGGGII 82
Cdd:cd00464    1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLtKENAVIATGGGAV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506315561  83 LSAENRQYMQQNGMVIYLQASADILAERLMqhpENTQRPSLTGKSIvEEMEEVLAAREKLYCECANHIINA-QLSPE 158
Cdd:cd00464   81 LREENRRLLLENGIVVWLDASPEELLERLA---RDKTRPLLQDEDP-ERLRELLEEREPLYREVADLTIDTdELSPE 153
SKI pfam01202
Shikimate kinase;
11-168 4.13e-58

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 178.93  E-value: 4.13e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   11 RGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQKNR-VISTGGGIILSAENRQ 89
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGlVIATGGGAVLSEENRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   90 YMQQNGMVIYLQASADILAERLMQhpeNTQRPSLTGKSIVEEMEEVLAA-REKLYCECANHIIN-AQLSPEKIttcVKEI 167
Cdd:pfam01202  81 LLKERGIVIYLDAPLEVLLERLKR---DKTRPLLQNKDPEEELLELLFEeRDPLYEEAADIVIDtDESSPEEV---ATEI 154


                  .
gi 506315561  168 I 168
Cdd:pfam01202 155 L 155
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 2-67 4.05e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 35.81  E-value: 4.05e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506315561     2 NPILFIVGARGAGKTTVGKLLANELSYT-----FIDTDHHIQQTSNMTIADIVNRQGW-----QQFRQLESQALQQ 67
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggviYIDGEDILEEVLDQLLLIIVGGKKAsgsgeLRLRLALALARKL 77
 
Name Accession Description Interval E-value
aroL PRK03731
shikimate kinase AroL;
1-171 4.72e-111

shikimate kinase AroL;


Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 313.03  E-value: 4.72e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   1 MNPILFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQKNRVISTGGG 80
Cdd:PRK03731   1 MTQPLFLVGARGCGKTTVGMALAQALGYRFVDTDQWLQSTSNMTVAEIVEREGWAGFRARESAALEAVTAPSTVIATGGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  81 IILSAENRQYMQQNGMVIYLQASADILAERLMQHPENTQRPSLTGKSIVEEMEEVLAAREKLYCECANHIINAQLSPEKI 160
Cdd:PRK03731  81 IILTEENRHFMRNNGIVIYLCAPVSVLANRLEANPEEDQRPTLTGKPISEEVAEVLAEREALYREVAHHIIDATQPPSQV 160

                        170
                 ....*....|.
gi 506315561 161 TTCVKEIILSR 171
Cdd:PRK03731 161 VSEILSALAQS 171
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 5-168 2.69e-66

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 199.58  E-value: 2.69e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   5 LFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQK-NRVISTGGGIIL 83
Cdd:COG0703    1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEeNAVIATGGGAVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  84 SAENRQYMQQNGMVIYLQASADILAERLMQhpeNTQRPSLTGKSIVEEMEEVLAAREKLYCECANHIINA-QLSPEKItt 162
Cdd:COG0703   81 SPENRELLKEHGTVVYLDASPETLLERLRR---DDNRPLLQGEDPRERLEELLAEREPLYREVADITVDTdGRSPEEV-- 155


                 ....*.
gi 506315561 163 cVKEII 168
Cdd:COG0703  156 -VDEIL 160
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 4-158 1.27e-63

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 192.77  E-value: 1.27e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   4 ILFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVS-QKNRVISTGGGII 82
Cdd:cd00464    1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLtKENAVIATGGGAV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506315561  83 LSAENRQYMQQNGMVIYLQASADILAERLMqhpENTQRPSLTGKSIvEEMEEVLAAREKLYCECANHIINA-QLSPE 158
Cdd:cd00464   81 LREENRRLLLENGIVVWLDASPEELLERLA---RDKTRPLLQDEDP-ERLRELLEEREPLYREVADLTIDTdELSPE 153
SKI pfam01202
Shikimate kinase;
11-168 4.13e-58

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 178.93  E-value: 4.13e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   11 RGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQKNR-VISTGGGIILSAENRQ 89
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGlVIATGGGAVLSEENRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   90 YMQQNGMVIYLQASADILAERLMQhpeNTQRPSLTGKSIVEEMEEVLAA-REKLYCECANHIIN-AQLSPEKIttcVKEI 167
Cdd:pfam01202  81 LLKERGIVIYLDAPLEVLLERLKR---DKTRPLLQNKDPEEELLELLFEeRDPLYEEAADIVIDtDESSPEEV---ATEI 154


                  .
gi 506315561  168 I 168
Cdd:pfam01202 155 L 155
aroK PRK00131
shikimate kinase; Reviewed
 1-168 2.96e-55

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 171.91  E-value: 2.96e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   1 MNPILFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQKNR-VISTGG 79
Cdd:PRK00131   3 KGPNIVLIGFMGAGKSTIGRLLAKRLGYDFIDTDHLIEARAGKSIPEIFEEEGEAAFRELEEEVLAELLARHNlVISTGG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  80 GIILSAENRQYMQQNGMVIYLQASADILAERLmqhPENTQRPSLTGKSIVEEMEEVLAAREKLYCECANHIIN-AQLSPE 158
Cdd:PRK00131  83 GAVLREENRALLRERGTVVYLDASFEELLRRL---RRDRNRPLLQTNDPKEKLRDLYEERDPLYEEVADITVEtDGRSPE 159

                        170
                 ....*....|
gi 506315561 159 KITTCVKEII 168
Cdd:PRK00131 160 EVVNEILEKL 169
PRK13946 PRK13946
shikimate kinase; Provisional
 5-168 8.07e-34

shikimate kinase; Provisional


Pssm-ID: 184411 [Multi-domain]  Cd Length: 184  Bit Score: 117.72  E-value: 8.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   5 LFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQ-VSQKNRVISTGGGIIL 83
Cdd:PRK13946  13 VVLVGLMGAGKSTVGRRLATMLGLPFLDADTEIERAARMTIAEIFAAYGEPEFRDLERRVIARlLKGGPLVLATGGGAFM 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  84 SAENRQYMQQNGMVIYLQASADILAERLMQHPEntqRPSLTGKSIVEEMEEVLAAREKLYCECANHIINAQLSPEKIttc 163
Cdd:PRK13946  93 NEETRAAIAEKGISVWLKADLDVLWERVSRRDT---RPLLRTADPKETLARLMEERYPVYAEADLTVASRDVPKEVM--- 166


                 ....*
gi 506315561 164 VKEII 168
Cdd:PRK13946 167 ADEVI 171
PRK13949 PRK13949
shikimate kinase; Provisional
 1-153 1.35e-33

shikimate kinase; Provisional


Pssm-ID: 140006 [Multi-domain]  Cd Length: 169  Bit Score: 116.75  E-value: 1.35e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   1 MNPIlFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQ-KNRVISTGG 79
Cdd:PRK13949   1 MARI-FLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHEVAEfEDVVISTGG 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 506315561  80 GIILSAENRQYMQQNGMVIYLQASADILAERL--MQHpentQRPSLTGKSIVEEME---EVLAAREKLYCEcANHIINA 153
Cdd:PRK13949  80 GAPCFFDNMELMNASGTTVYLKVSPEVLFVRLrlAKQ----QRPLLKGKSDEELLDfiiEALEKRAPFYRQ-AKIIFNA 153
PRK13947 PRK13947
shikimate kinase; Provisional
 1-173 1.71e-33

shikimate kinase; Provisional


Pssm-ID: 184412 [Multi-domain]  Cd Length: 171  Bit Score: 116.73  E-value: 1.71e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   1 MNPILFIvGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVS-QKNRVISTGG 79
Cdd:PRK13947   1 MKNIVLI-GFMGTGKTTVGKRVATTLSFGFIDTDKEIEKMTGMTVAEIFEKDGEVRFRSEEKLLVKKLArLKNLVIATGG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  80 GIILSAENRQYMQQNGMVIYLQASADILAERLMQhpeNTQRPSLTGKSIVEEMEEVLAAREKLYcECANHIIN-AQLSPE 158
Cdd:PRK13947  80 GVVLNPENVVQLRKNGVVICLKARPEVILRRVGK---KKSRPLLMVGDPEERIKELLKEREPFY-DFADYTIDtGDMTID 155

                        170
                 ....*....|....*
gi 506315561 159 KIttcVKEIILSRII 173
Cdd:PRK13947 156 EV---AEEIIKAYLK 167
aroK PRK05057
shikimate kinase AroK;
5-151 3.73e-26

shikimate kinase AroK;


Pssm-ID: 235335 [Multi-domain]  Cd Length: 172  Bit Score: 97.86  E-value: 3.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   5 LFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQK-NRVISTGGGIIL 83
Cdd:PRK05057   7 IFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADIGWVFDVEGEEGFRDREEKVINELTEKqGIVLATGGGSVK 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506315561  84 SAENRQYMQQNGMVIYLQASADilaERLMQHPENTQRPSLTGKSIVEEMEEVLAAREKLYCECANHII 151
Cdd:PRK05057  87 SRETRNRLSARGVVVYLETTIE---KQLARTQRDKKRPLLQVDDPREVLEALANERNPLYEEIADVTI 151
PRK13948 PRK13948
shikimate kinase; Provisional
 7-168 6.21e-26

shikimate kinase; Provisional


Pssm-ID: 184413 [Multi-domain]  Cd Length: 182  Bit Score: 97.55  E-value: 6.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   7 IVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQKNR-VISTGGGIILSA 85
Cdd:PRK13948  15 LAGFMGTGKSRIGWELSRALMLHFIDTDRYIERVTGKSIPEIFRHLGEAYFRRCEAEVVRRLTRLDYaVISLGGGTFMHE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  86 ENRQYMQQNGMVIYLQASADILAERLMQHpentQRPSLTGKSIVEEMEEVLAAREKLYCECANHIINAQLSPEKIttcVK 165
Cdd:PRK13948  95 ENRRKLLSRGPVVVLWASPETIYERTRPG----DRPLLQVEDPLGRIRTLLNEREPVYRQATIHVSTDGRRSEEV---VE 167


                 ...
gi 506315561 166 EII 168
Cdd:PRK13948 168 EIV 170
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
5-145 8.95e-24

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 96.51  E-value: 8.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   5 LFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQK-NRVISTGGGIIL 83
Cdd:PRK13951   3 IFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIERREGRSVRRIFEEDGEEYFRLKEKELLRELVERdNVVVATGGGVVI 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 506315561  84 SAENRQYMQQNGmVIYLQASADILAERLMQhpENtqRPSL-TGKsivEEMEEVLAAREKLYCE 145
Cdd:PRK13951  83 DPENRELLKKEK-TLFLYAPPEVLMERVTT--EN--RPLLrEGK---ERIREIWERRKQFYTE 137
PLN02199 PLN02199
shikimate kinase
 5-111 8.65e-21

shikimate kinase


Pssm-ID: 177850 [Multi-domain]  Cd Length: 303  Bit Score: 86.67  E-value: 8.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   5 LFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMT-IADIVNRQGWQQFRQLESQALQQVSQKNR-VISTGGGII 82
Cdd:PLN02199 105 MYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQAMNGTsVAEIFVHHGENFFRGKETDALKKLSSRYQvVVSTGGGAV 184

                         90       100
                 ....*....|....*....|....*....
gi 506315561  83 LSAENRQYMQQnGMVIYLQASADILAERL 111
Cdd:PLN02199 185 IRPINWKYMHK-GISIWLDVPLEALAHRI 212
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 8-152 4.38e-18

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 79.23  E-value: 4.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   8 VGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQKNR--VISTGGGIILSA 85
Cdd:PRK08154 139 IGLRGAGKSTLGRMLAARLGVPFVELNREIEREAGLSVSEIFALYGQEGYRRLERRALERLIAEHEemVLATGGGIVSEP 218

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506315561  86 ENRQYMQQNGMVIYLQASADILAERLMQhpENTQRPSLTGKSIVEEMEEVLAAREKLYcECANHIIN 152
Cdd:PRK08154 219 ATFDLLLSHCYTVWLKASPEEHMARVRA--QGDLRPMADNREAMEDLRRILASREPLY-ARADAVVD 282
PRK14021 PRK14021
bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional
 3-173 1.01e-16

bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional


Pssm-ID: 184458 [Multi-domain]  Cd Length: 542  Bit Score: 76.44  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   3 PILFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQTSNMTIADIVNRQGWQQFRQLESQALQQVSQK-NRVISTGGGI 81
Cdd:PRK14021   7 PQAVIIGMMGAGKTRVGKEVAQMMRLPFADADVEIEREIGMSIPSYFEEYGEPAFREVEADVVADMLEDfDGIFSLGGGA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  82 ILSAENR----QYMQQNGMVIYLQASAdilAERLMQHPENTQRPSLTGKSiVEEMEEVLAAREKLYCECAN-HIINAQLS 156
Cdd:PRK14021  87 PMTPSTQhalaSYIAHGGRVVYLDADP---KEAMERANRGGGRPMLNGDA-NKRWKKLFKQRDPVFRQVANvHVHTRGLT 162

                        170
                 ....*....|....*..
gi 506315561 157 PEKITTCVKEIILSRII 173
Cdd:PRK14021 163 PQAAAKKLIDMVAERTV 179
PRK00625 PRK00625
shikimate kinase; Provisional
 5-149 1.97e-15

shikimate kinase; Provisional


Pssm-ID: 134335 [Multi-domain]  Cd Length: 173  Bit Score: 69.78  E-value: 1.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   5 LFIVGARGAGKTTVGKLLANELSYTFIDTDHHIqqTSNM------TIADIVNRQGWQQFRQLESQALQQVSQKNRVISTG 78
Cdd:PRK00625   3 IFLCGLPTVGKTSFGKALAKFLSLPFFDTDDLI--VSNYhgalysSPKEIYQAYGEEGFCREEFLALTSLPVIPSIVALG 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 506315561  79 GGIILSAENRQYMQQNGMVIYLQASADILAERLMQH--PENTQR-PSLtgksiveemEEVLAAR-EKLYCECANH 149
Cdd:PRK00625  81 GGTLMIEPSYAHIRNRGLLVLLSLPIATIYQRLQKRglPERLKHaPSL---------EEILSQRiDRMRSIADYI 146
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 2-168 7.47e-11

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 57.45  E-value: 7.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   2 NPILFIVGARGAGKTTVGKLLANELSYTFIDTD-HH----IQQTSN---MTIADivnRQGWqqFRQLeSQALQQVSQKNR 73
Cdd:COG3265    1 PMVIVVMGVSGSGKSTVGQALAERLGWPFIDGDdFHppanIAKMAAgipLTDED---RAPW--LEAL-ADAIAAHLAAGE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  74 vistgGGII----LSAENRQYMQQN--GMV-IYLQASADILAERLMQHPENTQRPSLTgKSIveemeevLAAREKLYCEC 146
Cdd:COG3265   75 -----GAVLacsaLKRSYRDRLREGnpDVRfVYLDGSRELIAERLAARKGHFMPASLL-DSQ-------FATLEPPGPDE 141

                        170       180
                 ....*....|....*....|..
gi 506315561 147 ANHIINAQLSPEKIttcVKEII 168
Cdd:COG3265  142 DAIVVDIDQPPEEI---VAQIL 160
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 4-134 2.41e-09

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 53.03  E-value: 2.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   4 ILFIVGARGAGKTTVGKLLANELSYTFIDTD--HHIQQTSNMTIADIVN---RQGWqqfrqlesqaLQQVSQK--NRVIS 76
Cdd:cd02021    1 IIVVMGVSGSGKSTVGKALAERLGAPFIDGDdlHPPANIAKMAAGIPLNdedRWPW----------LQALTDAllAKLAS 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506315561  77 TGGGIIL--SAENRQY--------MQQNGMVIYLQASADILAERlMQHPENTQRPSLTGKSIVEEMEE 134
Cdd:cd02021   71 AGEGVVVacSALKRIYrdilrggaANPRVRFVHLDGPREVLAER-LAARKGHFMPADLLDSQFETLEP 137
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
12-171 6.91e-07

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 47.13  E-value: 6.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  12 GAGKTTVGKLLANELSYTFIDTD--HHIQQTSNMTIADI----------VNRQGWQ--QFRQLESQALQQVSQKNRVI-- 75
Cdd:COG1102   10 GSGGTTIAKRLAEKLGLPLYDGEilREAAKERGLSEEEFekldekapslLYRDTAEedEIDRALDKVIRELARKGNCViv 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  76 STGGGIILSAENrqymqqNGMVIYLQASADILAERLMqhpentQRPSLTGKSIVEEMEEVLAAREKLYCECANH------ 149
Cdd:COG1102   90 GRLADWILRDRP------NVLKVFLTAPLEVRVKRIA------EREGISEEEAEKEIKKRDKSRAKYYKYYYGIdwgdps 157

                        170       180
                 ....*....|....*....|....*..
gi 506315561 150 ----IIN-AQLSPEKITTCVKEIILSR 171
Cdd:COG1102  158 nydlVINtSRLGIEEAVDLILAAIEAR 184
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 5-138 2.50e-06

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 44.99  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561    5 LFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQtsnMTIADIVNRQGWQQFRQLESQALQQVSQKnrVISTGGGII-- 82
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKR---LFGEGRPSISYYTDATDRTYERLHELARI--ALRAGRPVIld 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506315561   83 ---LSAENRQYM----QQNGM---VIYLQASADILAERLMQHPENTQRPSLTGKSIVEEMEEVLAA 138
Cdd:pfam13671  77 atnLRRDERARLlalaREYGVpvrIVVFEAPEEVLRERLAARARAGGDPSDVPEEVLDRQKARFEP 142
AAA_18 pfam13238
AAA domain;
6-111 5.26e-06

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 43.57  E-value: 5.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561    6 FIVGARGAGKTTVGKLLANELSYTFIDTDHHiqQTSNMTIADivnRQGWQQFRQLESQALQQVSQKNRVIST---GGGII 82
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGFGDNVRDLA--LENGLVLGD---DPETRESKRLDEDKLDRLLDLLEENAAleeGGNLI 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 506315561   83 LS---AENRQYMQQNGMVIYLQASADILAERL 111
Cdd:pfam13238  77 IDghlAELEPERAKDLVGIVLRASPEELLERL 108
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 7-141 1.10e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 43.24  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   7 IVGARGAGKTTVGKLLANELSYTFIDT-DHHIQQTSNM--TIADI-------VNRQgwqqfrqlesqalqqvsqknRVIS 76
Cdd:cd02020    4 IDGPAGSGKSTVAKLLAKKLGLPYLDTgGIRTEEVGKLasEVAAIpevrkalDERQ--------------------RELA 63

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 506315561  77 TGGGIILsaENRQyMqqnGMV--------IYLQASADILAERLMQhpENTQRpsltGKSI-VEEMEEVLAAREK 141
Cdd:cd02020   64 KKPGIVL--EGRD-I---GTVvfpdadlkIFLTASPEVRAKRRAK--QLQAK----GEGVdLEEILAEIIERDE 125
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 4-143 3.37e-05

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 42.22  E-value: 3.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   4 ILFIVGARGAGKTTVGKLLANELSYTFIDT----DHHIQQTSN--MTIADIVNRQGW---QQFRQLESQALQQVSQKNrv 74
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTgdllREEIASGTElgKKAKEYIDSGKLvpdEIVIKLLKERLKKPDCKK-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  75 istggGIIL-----SAENRQYMQQNG-------MVIYLQASADILAERLMQHPE--------NTQRPSLTGKSIV---EE 131
Cdd:cd01428   79 -----GFILdgfprTVDQAEALDELLdegikpdKVIELDVPDEVLIERILGRRIcpvsgrvyHLGKDDVTGEPLSqrsDD 153

                        170
                 ....*....|..
gi 506315561 132 MEEVLAAREKLY 143
Cdd:cd01428  154 NEETIKKRLEVY 165
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
4-158 5.46e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 41.44  E-value: 5.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561   4 ILFIVGARGAGKTTVGKLLANELSYTFIDTDHHIQQtsnMTIADIVNRQGWQQFRQLESQALQQVSQknRVISTGGGIIL 83
Cdd:COG0645    1 LILVCGLPGSGKSTLARALAERLGAVRLRSDVVRKR---LFGAGLAPLERSPEATARTYARLLALAR--ELLAAGRSVIL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561  84 -----SAENRQYM----QQNG---MVIYLQASADILAERLMQHPENTQRPSLTgksiVEEMEEVLAAREKL-YCECANHI 150
Cdd:COG0645   76 datflRRAQREAFralaEEAGapfVLIWLDAPEEVLRERLEARNAEGGDSDAT----WEVLERQLAFEEPLtEDEGFLLV 151


                 ....*...
gi 506315561 151 INAQLSPE 158
Cdd:COG0645  152 VDTSGLEE 159
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
12-33 1.43e-04

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 40.78  E-value: 1.43e-04
                         10        20
                 ....*....|....*....|..
gi 506315561  12 GAGKTTVGKLLANELSYTFIDT 33
Cdd:COG0283   10 GSGKSTVAKALAKRLGYHYLDT 31
AAA_24 pfam13479
AAA domain; This AAA domain is found in a wide variety of presumed phage proteins.
 1-60 5.85e-04

AAA domain; This AAA domain is found in a wide variety of presumed phage proteins.


Pssm-ID: 433243  Cd Length: 199  Bit Score: 38.85  E-value: 5.85e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 506315561    1 MNPILFIVGARGAGKTTVGKLLANELsytFIDTDHHIQQTSNMTIADIVNRQGWQQFRQL 60
Cdd:pfam13479   1 KKLKILIYGPSGIGKTTFAKTLPKPL---FLDTEKGSKALDGDRFPDIVIRDSWQDFLDA 57
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
2-32 1.04e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 38.77  E-value: 1.04e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 506315561   2 NPILFIVGARGAGKTTVGKLLANEL-SYTFID 32
Cdd:COG1373   20 RKAVVITGPRQVGKTTLLKQLAKELeNILYIN 51
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 2-35 1.66e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 36.80  E-value: 1.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 506315561    2 NPILFIVGARGAGKTTVGKLLANEL----SYTFIDTDH 35
Cdd:pfam13173   2 RKILVITGPRQVGKTTLLLQLIKELlppeNILYINLDD 39
PRK06217 PRK06217
hypothetical protein; Validated
 5-34 2.07e-03

hypothetical protein; Validated


Pssm-ID: 168472  Cd Length: 183  Bit Score: 36.95  E-value: 2.07e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 506315561   5 LFIVGARGAGKTTVGKLLANELSYTFIDTD 34
Cdd:PRK06217   4 IHITGASGSGTTTLGAALAERLDIPHLDTD 33
PRK13477 PRK13477
bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;
2-33 3.36e-03

bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;


Pssm-ID: 237393 [Multi-domain]  Cd Length: 512  Bit Score: 37.17  E-value: 3.36e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 506315561   2 NPILFIVGARGAGKTTVGKLLANELSYTFIDT 33
Cdd:PRK13477 284 QPIIAIDGPAGAGKSTVTRAVAKKLGLLYLDT 315
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 2-67 4.05e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 35.81  E-value: 4.05e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506315561     2 NPILFIVGARGAGKTTVGKLLANELSYT-----FIDTDHHIQQTSNMTIADIVNRQGW-----QQFRQLESQALQQ 67
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggviYIDGEDILEEVLDQLLLIIVGGKKAsgsgeLRLRLALALARKL 77
PRK03839 PRK03839
putative kinase; Provisional
 4-32 7.90e-03

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 35.47  E-value: 7.90e-03
                         10        20
                 ....*....|....*....|....*....
gi 506315561   4 ILFIVGARGAGKTTVGKLLANELSYTFID 32
Cdd:PRK03839   2 IIAITGTPGVGKTTVSKLLAEKLGYEYVD 30
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 7-34 8.92e-03

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 35.30  E-value: 8.92e-03
                          10        20
                  ....*....|....*....|....*...
gi 506315561    7 IVGARGAGKTTVGKLLANELSYTFIDTD 34
Cdd:pfam13189   4 ISRQYGSGGTTIAKKLAEKLGYPFYDRE 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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