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Conserved domains on  [gi|506223037|ref|WP_015742812|]
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sulfurtransferase TusA [Cronobacter turicensis]

Protein Classification

sulfurtransferase( domain architecture ID 10011363)

sulfurtransferase TusA, which interacts with cysteine desulfurase IscS and acts as the first member in a sulfur relay mechanism, transfering sulfur to the TusBCD complex

Gene Ontology:  GO:0097163

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00299 PRK00299
sulfurtransferase TusA;
1-81 5.69e-57

sulfurtransferase TusA;


:

Pssm-ID: 178967  Cd Length: 81  Bit Score: 169.05  E-value: 5.69e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506223037  1 MTDLFANPDHTLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRKN 80
Cdd:PRK00299  1 MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPSFCRFMDHELLAQETEQLPYRYLIRKG 80


                .
gi 506223037 81 Q 81
Cdd:PRK00299 81 L 81
 
Name Accession Description Interval E-value
PRK00299 PRK00299
sulfurtransferase TusA;
1-81 5.69e-57

sulfurtransferase TusA;


Pssm-ID: 178967  Cd Length: 81  Bit Score: 169.05  E-value: 5.69e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506223037  1 MTDLFANPDHTLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRKN 80
Cdd:PRK00299  1 MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPSFCRFMDHELLAQETEQLPYRYLIRKG 80


                .
gi 506223037 81 Q 81
Cdd:PRK00299 81 L 81
SirA cd03423
SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators ...
 11-79 8.33e-42

SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is thought to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239515  Cd Length: 69  Bit Score: 130.56  E-value: 8.33e-42
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 506223037 11 TLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRK 79
Cdd:cd03423   1 ILDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGHELLAQETEDEPYRYLIRK 69
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 12-79 3.33e-30

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 101.43  E-value: 3.33e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506223037 12 LDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRK 79
Cdd:COG0425   1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELLSVEEEGGVYRILIRK 68
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 11-65 3.39e-20

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 75.69  E-value: 3.39e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 506223037  11 TLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVA 65
Cdd:pfam01206  1 TLDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLE 55
 
Name Accession Description Interval E-value
PRK00299 PRK00299
sulfurtransferase TusA;
1-81 5.69e-57

sulfurtransferase TusA;


Pssm-ID: 178967  Cd Length: 81  Bit Score: 169.05  E-value: 5.69e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506223037  1 MTDLFANPDHTLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRKN 80
Cdd:PRK00299  1 MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPSFCRFMDHELLAQETEQLPYRYLIRKG 80


                .
gi 506223037 81 Q 81
Cdd:PRK00299 81 L 81
SirA cd03423
SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators ...
 11-79 8.33e-42

SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is thought to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239515  Cd Length: 69  Bit Score: 130.56  E-value: 8.33e-42
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 506223037 11 TLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRK 79
Cdd:cd03423   1 ILDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGHELLAQETEDEPYRYLIRK 69
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 12-79 3.33e-30

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 101.43  E-value: 3.33e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506223037 12 LDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRK 79
Cdd:COG0425   1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELLSVEEEGGVYRILIRK 68
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 11-79 4.51e-26

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 90.69  E-value: 4.51e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 506223037 11 TLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRK 79
Cdd:cd00291   1 TLDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEVEEEGGVYRILIRK 69
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 11-65 3.39e-20

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 75.69  E-value: 3.39e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 506223037  11 TLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVA 65
Cdd:pfam01206  1 TLDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLE 55
SirA_RHOD_Pry_redox cd03420
SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown ...
 11-69 3.79e-14

SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that corresponds to COG2210. This fold is referred to as a two-layered alpha/beta sandwich, structurally similar to that of translation initiation factor 3.


Pssm-ID: 239512  Cd Length: 69  Bit Score: 60.47  E-value: 3.79e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 506223037 11 TLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTE 69
Cdd:cd03420   1 EVDACGLQCPGPILKLKKEIDKLQDGEQLEVKASDPGFARDAQAWCKSTGNTLISLETE 59
PRK11018 PRK11018
putative sulfurtransferase YedF;
8-79 2.18e-10

putative sulfurtransferase YedF;


Pssm-ID: 236822  Cd Length: 78  Bit Score: 51.20  E-value: 2.18e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506223037  8 PDHTLDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRK 79
Cdd:PRK11018  7 PDYRLDMVGEPCPYPAVATLEALPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQQDGPTIRYLIQK 78
YedF cd03422
YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and ...
 12-79 4.81e-06

YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239514  Cd Length: 69  Bit Score: 40.10  E-value: 4.81e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506223037 12 LDALGLRCPEPIMMVRKTVRQMQPGETLLIVADDPATTRDIPGFCRFMEHELVASQTETLPYRYLLRK 79
Cdd:cd03422   2 LDLRGEPCPYPAIATLEALPSLKPGEILEVISDCPQSINNIPIDARNHGYKVLAIEQSGPTIRYLIQK 69
SirA_like_N cd03421
SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, ...
 11-61 1.35e-05

SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239513  Cd Length: 67  Bit Score: 38.72  E-value: 1.35e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 506223037 11 TLDALGLRCPEPIMMVRKTVRQmQPGETLLIVADDPATTRDIpgfCRFMEH 61
Cdd:cd03421   1 TIDARGLACPQPVIKTKKALEL-EAGGEIEVLVDNEVAKENV---SRFAES 47
DUF2249 pfam10006
Uncharacterized conserved protein (DUF2249); Members of this family of hypothetical bacterial ...
 11-46 4.93e-03

Uncharacterized conserved protein (DUF2249); Members of this family of hypothetical bacterial proteins have no known function.


Pssm-ID: 430983  Cd Length: 70  Bit Score: 32.13  E-value: 4.93e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 506223037  11 TLDALGLRCPEPIMMVRKTVRQMQPGETLLIVAD-DP 46
Cdd:pfam10006  1 TLDVRGLPPPEPHAAIFEAFDALAPGETLRLVNDhDP 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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