|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
1-400 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 715.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 1 MTQYASPLLQTLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDD-LLGIYADAIREQVDAMQHLALSDAEYQWLSGLPF 79
Cdd:PRK05321 1 HTWKADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 80 FRADYLQWLKTFRYDPTQVQIRNDGGKLDIRLSGPWREVIMWEVPLLAVISELVHRYRTPEASVDQALAHLEVKLDDFha 159
Cdd:PRK05321 81 FKPDFLDWLRLFRLNPYEVTVSIDDGQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIELL-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 160 mTDGLDLSAFRLMDFGTRRRFSRDVQQAIVERLK--LEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQ 237
Cdd:PRK05321 159 -KALPDLSGFKIADFGTRRRFSFEWQEEVVEALKegLPGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 238 IAALQAWLDEYPDMLGIALTDCITMDAFLRDFGPEFAGRYQGLRHDSGDPVQWGEKAIAHYQQLGIDPLSKTLIFSDNLD 317
Cdd:PRK05321 238 YAALEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 318 FAKAIELYRHFADRVKLGFGIGTRLTCDIPHVKPLNIVIKLVECNGRPVAKLSDSPGKTICHDKAFVRALRKAFDLPLVR 397
Cdd:PRK05321 318 FDKALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVFGLPLVV 397
|
...
gi 506220961 398 KAS 400
Cdd:PRK05321 398 KAS 400
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
10-376 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 591.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 10 QTLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGD-DLLGIYADAIREQVDAMQHLALSDAEYQWLS-GLPFFRADYLQW 87
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPeDFLEEAAEALREQIDHLANLRFSEEELAYLRrSLPFLKPDYLDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 88 LKTFRYDPTQVQIRND--GGKLDIRLSGPWREVIMWEVPLLAVISELVHRYRTPEASVDQALAHLEVKLDDFHAMTDGLD 165
Cdd:cd01401 81 LELFRLNPEEVVVRLDtgKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 166 LSAFRLMDFGTRRRFSRDVQQAIVERLK--LEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQIAALQA 243
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKqaAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 244 WLDEYPDMLGIALTDCITMDAFLRDFGPEFAGRYQGLRHDSGDPVQWGEKAIAHYQQLGIDPLSKTLIFSDNLDFAKAIE 323
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 506220961 324 LYRHFADRVKLGFGIGTRLTCDIPH---VKPLNIVIKLVECNGRPVAKLSDSPGKT 376
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGNkekSTPLNIVIKLVECNGRPVAKISDSPGKN 376
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
8-394 |
0e+00 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 572.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 8 LLQTLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDL-LGIYADAIREQVDAMQHLALSDAEYQWL-SGLPFFRADYL 85
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQLfLKEAAEALREEISALGNLRFTDDEIEYLkQELPYLKSDYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 86 QWLKTFRYDPT-QVQI-RNDGGKLDIRLSGPWREVIMWEVPLLAVISELVHRYRTPEASVDQALAHLEVKLDDFHAMTDG 163
Cdd:TIGR01514 81 DYLRNFRFHPEeQVEVgIDDKGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 164 LDLS--AFRLMDFGTRRRFSRDVQQAIVERLKLE--PWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPdLANSQIA 239
Cdd:TIGR01514 161 ETMFenGFRFSEFGTRRRFSLEVQDLVTQGLKQAapSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 240 ALQAWLDEYPDMLGIALTDCITMDAFLRDFGPEFAGRYQGLRHDSGDPVQWGEKAIAHYQQLGIDPLSKTLIFSDNLDFA 319
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 506220961 320 KAIELYRHFADRVKLGFGIGTRLTCDIPHVKPLNIVIKLVECNGRPVAKLSDSPGKTICHDKAFVRALRKAFDLP 394
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELFDTP 394
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
169-395 |
1.17e-110 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 323.95 E-value: 1.17e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 169 FRLMDFGTRRRFSRDVQQAIVerLKLEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQIAALQAWLDEY 248
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQEIVG--LAHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHAEY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 249 PDMLGIALTDCITMDAFLRDFGPEFAGRYQGLRHDSGDPVQWGEKAIAHYQQL-GIDPLSKTLIFSDNLDFAKAIELYRH 327
Cdd:pfam04095 79 RGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTlNIDGYTKRLIFSDGLDVEKIIELLEY 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506220961 328 F-ADRVKLGFGIGTRLTCDIPH--------VKPLNIVIKLVECNGRPVAKLSDSPGKTICHDKAFVRALRKAFDLPL 395
Cdd:pfam04095 159 FkGKGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFDNGE 235
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
11-376 |
9.31e-29 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 116.40 E-value: 9.31e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 11 TLLDTDAYKL-HMQQAVFHHYYDVHVAAEFRCR-----GDDLL--GIyadairEQV-DAMQHLALSDAEYQWLSGLPFFR 81
Cdd:COG1488 4 LALLTDLYKLtMAQAYLPEGTANRRAVFELFFRrlpfgRGYVVfaGL------QRFlKYLENLRFTEEDIAYLRSLGVFD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 82 ADYLQWLKTFR-------------YDPTQVqirndggklDIRLSGPWREVIMWEVPLLAVISelvhrYRTPEASvdqalA 148
Cdd:COG1488 78 EDFLDYLADFRfpgdiravpegtvVFPGEP---------LLTVEGTLPEAQLLETLLLNILN-----YPTLIAT-----K 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 149 HLEVKL--DDFhamtdgldlsafRLMDFGTRRRFSRDVQQAIVeRLKLEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAH 226
Cdd:COG1488 139 AARIVQaaGGR------------PLHDFGLRRAHGLEAAVAAA-RAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAH 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 227 qqispdlaNSQIAALQAWLDEYPDMLgIALTDciTMD--AFLRDfGPEFAGRYQ------GLRHDSGDPVQWGEKAIAHY 298
Cdd:COG1488 206 --------DDELEAFRAFAEAYPDGT-TLLVD--TYDtlSGVPN-AIELAKELLarggllGIRLDSGDLAYLSKQARELL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 299 QQLGidpLSKTLIF-SDNLDFAKAIELYRHFA--DrvklGFGIGTRL-TC-DIPHvkpLNIVIKLVECNG----RPVAKL 369
Cdd:COG1488 274 DEAG---LPDVRIIaSDDLDEYRIAALLEQGApiD----VFGVGTRLvTSsDRPT---LGFVYKLVAVEGdgewRPVIKL 343
|
....*..
gi 506220961 370 SDSPGKT 376
Cdd:COG1488 344 SETPGKK 350
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
1-400 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 715.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 1 MTQYASPLLQTLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDD-LLGIYADAIREQVDAMQHLALSDAEYQWLSGLPF 79
Cdd:PRK05321 1 HTWKADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 80 FRADYLQWLKTFRYDPTQVQIRNDGGKLDIRLSGPWREVIMWEVPLLAVISELVHRYRTPEASVDQALAHLEVKLDDFha 159
Cdd:PRK05321 81 FKPDFLDWLRLFRLNPYEVTVSIDDGQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIELL-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 160 mTDGLDLSAFRLMDFGTRRRFSRDVQQAIVERLK--LEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQ 237
Cdd:PRK05321 159 -KALPDLSGFKIADFGTRRRFSFEWQEEVVEALKegLPGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 238 IAALQAWLDEYPDMLGIALTDCITMDAFLRDFGPEFAGRYQGLRHDSGDPVQWGEKAIAHYQQLGIDPLSKTLIFSDNLD 317
Cdd:PRK05321 238 YAALEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 318 FAKAIELYRHFADRVKLGFGIGTRLTCDIPHVKPLNIVIKLVECNGRPVAKLSDSPGKTICHDKAFVRALRKAFDLPLVR 397
Cdd:PRK05321 318 FDKALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVFGLPLVV 397
|
...
gi 506220961 398 KAS 400
Cdd:PRK05321 398 KAS 400
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
10-376 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 591.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 10 QTLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGD-DLLGIYADAIREQVDAMQHLALSDAEYQWLS-GLPFFRADYLQW 87
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPeDFLEEAAEALREQIDHLANLRFSEEELAYLRrSLPFLKPDYLDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 88 LKTFRYDPTQVQIRND--GGKLDIRLSGPWREVIMWEVPLLAVISELVHRYRTPEASVDQALAHLEVKLDDFHAMTDGLD 165
Cdd:cd01401 81 LELFRLNPEEVVVRLDtgKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 166 LSAFRLMDFGTRRRFSRDVQQAIVERLK--LEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQIAALQA 243
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKqaAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 244 WLDEYPDMLGIALTDCITMDAFLRDFGPEFAGRYQGLRHDSGDPVQWGEKAIAHYQQLGIDPLSKTLIFSDNLDFAKAIE 323
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 506220961 324 LYRHFADRVKLGFGIGTRLTCDIPH---VKPLNIVIKLVECNGRPVAKLSDSPGKT 376
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGNkekSTPLNIVIKLVECNGRPVAKISDSPGKN 376
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
8-394 |
0e+00 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 572.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 8 LLQTLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDL-LGIYADAIREQVDAMQHLALSDAEYQWL-SGLPFFRADYL 85
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQLfLKEAAEALREEISALGNLRFTDDEIEYLkQELPYLKSDYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 86 QWLKTFRYDPT-QVQI-RNDGGKLDIRLSGPWREVIMWEVPLLAVISELVHRYRTPEASVDQALAHLEVKLDDFHAMTDG 163
Cdd:TIGR01514 81 DYLRNFRFHPEeQVEVgIDDKGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 164 LDLS--AFRLMDFGTRRRFSRDVQQAIVERLKLE--PWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPdLANSQIA 239
Cdd:TIGR01514 161 ETMFenGFRFSEFGTRRRFSLEVQDLVTQGLKQAapSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 240 ALQAWLDEYPDMLGIALTDCITMDAFLRDFGPEFAGRYQGLRHDSGDPVQWGEKAIAHYQQLGIDPLSKTLIFSDNLDFA 319
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 506220961 320 KAIELYRHFADRVKLGFGIGTRLTCDIPHVKPLNIVIKLVECNGRPVAKLSDSPGKTICHDKAFVRALRKAFDLP 394
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELFDTP 394
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
169-395 |
1.17e-110 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 323.95 E-value: 1.17e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 169 FRLMDFGTRRRFSRDVQQAIVerLKLEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQIAALQAWLDEY 248
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQEIVG--LAHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHAEY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 249 PDMLGIALTDCITMDAFLRDFGPEFAGRYQGLRHDSGDPVQWGEKAIAHYQQL-GIDPLSKTLIFSDNLDFAKAIELYRH 327
Cdd:pfam04095 79 RGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTlNIDGYTKRLIFSDGLDVEKIIELLEY 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506220961 328 F-ADRVKLGFGIGTRLTCDIPH--------VKPLNIVIKLVECNGRPVAKLSDSPGKTICHDKAFVRALRKAFDLPL 395
Cdd:pfam04095 159 FkGKGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFDNGE 235
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
12-357 |
3.39e-97 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 293.79 E-value: 3.39e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 12 LLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDD--LLGIYADAIREQVDAMQHLALSDAEYQWLSG----------LPF 79
Cdd:cd01567 1 LLDTDLYKLTMMQAYLYPYPNTRVVFEFTFRSNPfgGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKllifgefflyLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 80 FRADYLQWLKTFRYDPtqVQIRNdggkLDIRLSGPWREVIMWEVPLLAVISELVHRYRTPEASVDQALAHLEVKlddfha 159
Cdd:cd01567 81 LGKLPLEIYALPEGTV--VFPKE----PLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLLETK------ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 160 mtDGLDLSAFRLMDFGTRRRFSRDvQQAIVERLKLEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHQqispDLANSQIA 239
Cdd:cd01567 149 --DNLEELGFKLHDFGTRRRHSPE-AALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFG----ALEEAAFE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 240 ALQAWLDEYPDMLGIALTDCITMD-AFLRDFGPEFA----GRYQGLRHDSGDPVQWGEKAIAHYQQLGIDPLSKTLIFSD 314
Cdd:cd01567 222 AFARWLPQFGGGLGIALIDTYDTDnGFLNALKLAKAlgagGGLLGVRLDSGDPVELIKKVRKHLDELGIDLNKKKIIISG 301
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 506220961 315 NLDFAKAIELYRHFADRVKLGFGIGTRLTCDIPhVKPLNIVIK 357
Cdd:cd01567 302 DLDTEEAIELLLEQGASPNDAFGVGTSLTNDLG-RPPLGFVYK 343
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
16-357 |
5.02e-44 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 154.32 E-value: 5.02e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 16 DAYKLHMQQAvfHHYYDVHVAAEFRCRGDDllGIYADAIREQVDAMQHLALSDaeyqwlsglpffradYLQWLKTFRYDP 95
Cdd:cd00516 1 DLYKLTMIQA--YPPPDTRATAEFTAREDP--YGVLAGLEEALELLELLRFPG---------------PLVILAVPEGTV 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 96 TQVqirndgGKLDIRLSGPWREVIMWEVPLLAVISELVHRYRTPEASVDQALAHlevklddfhamtdgldlsAFRLMDFG 175
Cdd:cd00516 62 VEP------GEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAKGA------------------NTKVHDFG 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 176 TRRRFSRDVQQAIVERLKlePWFIGTSNYDLARRLSLTPMGTQAHEWFQAHqqispdLANSQIAALQAWLDEypdmLGIA 255
Cdd:cd00516 118 TRKTTPGLRLLEKYAVLI--GGGDGHRNGLSDAILIKDNHGTMAHSIIQAF------GELAAVKALRRWLPE----LFIA 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 256 LTDCITMDaFLRDFGPEFAGRYQGLRHDSG-----DPVQWGEKAIAHYQqlGIDPLSKTLIFSDNLDfAKAIELYRHFAd 330
Cdd:cd00516 186 LIDVEVDT-LEEALEAAKAGGADGIRLDSGspeelDPAVLILKARAHLD--GKGLPRVKIEASGGLD-EENIRAYAETG- 260
|
330 340
....*....|....*....|....*..
gi 506220961 331 rvKLGFGIGTRLTCDiphvKPLNIVIK 357
Cdd:cd00516 261 --VDVFGVGTLLHSA----PPLDIVLK 281
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
13-130 |
5.54e-41 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 141.11 E-value: 5.54e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 13 LDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDLLG--IYADAIREQVDAMQHLALSDAEYQWLS-GLPFFRADYLQWLK 89
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQVVFEFFNRTNPFGGlyAVFAGLEEQIEFLENLRFTEEEIEYLRrSLPYFKPDFLDYLR 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 506220961 90 TFRYDPTQVQIRNDG----GKLDIRLSGPWREVIMWEVPLLAVIS 130
Cdd:pfam17767 81 NFRFDPSIVAVPEGEvvfpGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
11-376 |
9.31e-29 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 116.40 E-value: 9.31e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 11 TLLDTDAYKL-HMQQAVFHHYYDVHVAAEFRCR-----GDDLL--GIyadairEQV-DAMQHLALSDAEYQWLSGLPFFR 81
Cdd:COG1488 4 LALLTDLYKLtMAQAYLPEGTANRRAVFELFFRrlpfgRGYVVfaGL------QRFlKYLENLRFTEEDIAYLRSLGVFD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 82 ADYLQWLKTFR-------------YDPTQVqirndggklDIRLSGPWREVIMWEVPLLAVISelvhrYRTPEASvdqalA 148
Cdd:COG1488 78 EDFLDYLADFRfpgdiravpegtvVFPGEP---------LLTVEGTLPEAQLLETLLLNILN-----YPTLIAT-----K 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 149 HLEVKL--DDFhamtdgldlsafRLMDFGTRRRFSRDVQQAIVeRLKLEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAH 226
Cdd:COG1488 139 AARIVQaaGGR------------PLHDFGLRRAHGLEAAVAAA-RAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAH 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 227 qqispdlaNSQIAALQAWLDEYPDMLgIALTDciTMD--AFLRDfGPEFAGRYQ------GLRHDSGDPVQWGEKAIAHY 298
Cdd:COG1488 206 --------DDELEAFRAFAEAYPDGT-TLLVD--TYDtlSGVPN-AIELAKELLarggllGIRLDSGDLAYLSKQARELL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 299 QQLGidpLSKTLIF-SDNLDFAKAIELYRHFA--DrvklGFGIGTRL-TC-DIPHvkpLNIVIKLVECNG----RPVAKL 369
Cdd:COG1488 274 DEAG---LPDVRIIaSDDLDEYRIAALLEQGApiD----VFGVGTRLvTSsDRPT---LGFVYKLVAVEGdgewRPVIKL 343
|
....*..
gi 506220961 370 SDSPGKT 376
Cdd:COG1488 344 SETPGKK 350
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
13-388 |
2.19e-21 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 95.50 E-value: 2.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 13 LDTDAYKLHMQQAVFHH-------YYDVHvaaeFR----CRGddlLGIYAdAIREQVDAMQHLALSDAEYQWLSGLPFFR 81
Cdd:TIGR01513 2 LLTDLYELTMAQGYFREgkanqpaVFEVF----FRklpfGRG---YAVFA-GLEDLLEFLENFRFDAEDIEYLASLGIFD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 82 ADYLQWLKTFRYdptqvqirndggKLDIRlSGPWREVIMWEVPLLAVISELvhryrtPEASVDQALAHLEVKLDDFHAMT 161
Cdd:TIGR01513 74 DAFLDYLREFRF------------SGTVR-ALPEGSLVFPNEPLLQVEGPL------IEAQLLETLVLNIINFQTLIATK 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 162 DGLDLSAFR---LMDFGTRRrfSRDVQQAI-VERLKLEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHqqispdlaNSQ 237
Cdd:TIGR01513 135 AARIVLAAGgkpLLEFGLRR--AQGPDAALkAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF--------DNE 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 238 IAALQAWLDEYP----------DMLGIALTDCITMDAFLRDfgpefAGRYQGLRHDSGDPVQWGEKAIAHYQQLGidpLS 307
Cdd:TIGR01513 205 LAAFRAYAKLYPkatvllvdtyDTLRSGLPNAIAVAKELGE-----QGKVVGVRIDSGDLLYLSKQARKQLDAAG---LT 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 308 KTLIF-SDNLDFAKAIELyrhFADRVKL-GFGIGTRL-TC-DIPHvkpLNIVIKLVECNGRPVAKLSDSPGK-TICHDKA 382
Cdd:TIGR01513 277 QVKIVvSNDLDENSIAAL---KAEGAPIdVYGVGTSLvTAsDAPA---LGGVYKLVAYEGRPVMKLSENPEKsTLPGRKQ 350
|
....*.
gi 506220961 383 FVRALR 388
Cdd:TIGR01513 351 VFRLYD 356
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
11-377 |
3.57e-14 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 73.63 E-value: 3.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 11 TLLDTDAYKLHMQQAVFHH------YYDVHVAAEFRCRGddllGIYADAIREQVDAMQHLALSDAEYQWLSGLPFFRADY 84
Cdd:PRK12484 4 LALLTDLYEVTMANAYLREgmsapaTFSLFYRKLPDGRG----FLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQFSEEF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 85 LQWLKTFRYDPtqvqirndggklDIRlSGPWREVIMWEVPLLAVISELvhryrtPEASVDQALAHLEVKLDDFHAMTDGL 164
Cdd:PRK12484 80 LAWLAGLRFTG------------DVR-AVPEGTVVFPNEPLLEVTAPL------IEAQLVETFLLNQINHQSLIASKAAR 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 165 DLSAFR---LMDFGTRRRFSRDVQQAiVERLKLEPWFIGTSNYDLARRLSLTPMGTQAHEWFQAHqqisPDlansQIAAL 241
Cdd:PRK12484 141 CVLAAAgrpVVDFGARRAHGTDAACY-VARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAF----PD----EVAAF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 242 QAWLDEYPDMLgIALTDciTMDA---------FLRDFGPEFAGRyqGLRHDSGDpvqWGEKAIAHYQQLGIDPLSKTLIF 312
Cdd:PRK12484 212 RAFARLYPDAT-TLLVD--TYDTlrgvrnaieVAKELGNRFDPR--GVRLDSGD---LAELSKATRAILDAAGLEQVKIV 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 313 -SDNLDFAKAIELYRHFA--DrvklGFGIGTRL--TCDIPHvkpLNIVIKLVECNGRPVAKLsdSPGKTI 377
Cdd:PRK12484 284 aSGGLDEYRIAALLAAGApiD----GFGVGTRLgvAADAPV---LDSAYKLVAYEGRGVTKL--SSGKVT 344
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
58-376 |
3.62e-14 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 73.65 E-value: 3.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 58 VDAMQHLALSDAEYQWLSGLPFFRADYLQWLKTFRYdptqvqirndggKLDIRlSGPWREVIMWEVPLLAViselvhryr 137
Cdd:PRK09243 59 LEYLENLRFTEEDIEYLRSLGIFDEDFLDYLRNFRF------------TGDVR-AVPEGELVFPNEPLLRV--------- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 138 tpEASVDQALAhLEvklddfhamtdGLDLS-----------AFR---------LMDFGTRRRFSRDvqqAIVerlklepW 197
Cdd:PRK09243 117 --EGPLAEAQL-LE-----------TLLLNiinfqtliatkAARivsaaggrpLLEFGSRRAQGPD---AAV-------W 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 198 ---------FIGTSNYDLARRLSLTPMGTQAHEWFQAHqqispdlaNSQIAALQAWLDEYPDmlgialtDCItmdaFLRD 268
Cdd:PRK09243 173 aaraayiggFDATSNVLAGKRYGIPVSGTMAHSFVQAF--------DDEYEAFRAYAETYPD-------NTV----LLVD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 269 ---------------FGPEFAG-RYQGLRHDSGDpvqWGEKAIAHYQQLGIDPLSKTLIF-SDNLDfAKAIElyrhfadR 331
Cdd:PRK09243 234 tydtlksgvpnaikvAKELGDGiELGGVRIDSGD---LAYLSKKVRKMLDEAGFTDTKIVaSNDLD-EYTIA-------S 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 506220961 332 VKL------GFGIGTRL-TC-DIPhvkPLNIVIKLVECNG----RPVAKLSDSPGKT 376
Cdd:PRK09243 303 LKLqgapidGFGVGTKLvTGsDAP---ALGGVYKLVAIEGeggmIPKIKLSNSPEKV 356
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
13-359 |
5.90e-12 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 66.06 E-value: 5.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 13 LDTDAYKLHMQQAVFHH-------YYDVHvaaeFR----CRGddlLGIYAdAIREQVDAMQHLALSDAEYQWLSGLPFFR 81
Cdd:cd01570 2 LLTDLYQLTMAQAYWKEgkhnkpaVFELF----FRklpfGGG---YAVFA-GLEELLEYLENFRFTEEDIDYLRSLGIFD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 82 ADYLQWLKTFRYDptqvqirndgGKLD--------------IRLSGPWREVIMWEVPLLAVIS--ELV------HRYRTP 139
Cdd:cd01570 74 EEFLDYLRGFRFT----------GTIYaipegevvfpneplLTVEGPLIEAQLLETLLLNLINfqTLIatkaarVRLAAG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 140 EAsvdqalahlevklddfhamtdgldlsafRLMDFGTRRRFSRD--VQQAiveRLKLEPWFIGTSNYDLARRLSLTPMGT 217
Cdd:cd01570 144 GR----------------------------PLLEFGLRRAQGPDaaLSAA---RAAYIGGFDGTSNVLAGKLYGIPVSGT 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 218 QAHEWFQAHQqispdlanSQIAALQAWLDEYPDMLgIALTDciTMDA-------FLRDFGPEFAGRYQ--GLRHDSGDPV 288
Cdd:cd01570 193 MAHSFVQAFD--------DELAAFRAFAEAYPDNF-TLLVD--TYDTlrsglpnAIAVAKELGALGYRlvGVRIDSGDLA 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 506220961 289 QWGEKAIAHYQQLGidpLSKTLIF-SDNLDfAKAIELYRHFADRVkLGFGIGTRL-TC-DIPhvkPLNIVIKLV 359
Cdd:cd01570 262 YLSKEARKMLDEAG---LTKVKIVaSNDLD-EYTIAALNAQGAPI-DAFGVGTRLvTSqSQP---ALGGVYKLV 327
|
|
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
198-383 |
2.35e-04 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 43.11 E-value: 2.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 198 FIGTSNYDLARRLSLTPMGTQAHEWFQAHQQ----ISPDLANSQ--------IAALQAWLD---EYPDMLGI-------- 254
Cdd:PLN02885 188 FDATSNVEAGRLFGIPVRGTHSHAFVSSYMGldeiVDKTLRSADgssvcedfVSLVQEWLSklqESSSLRGVfsetnqse 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 255 ----------------ALTDciTMDAF-------------LRDFGpefagrYQ--GLRHDSGDPVQWGEKAIAHYQ---- 299
Cdd:PLN02885 268 laaftsyalafpnsflALVD--TYDVMksgipnfcavalaLNDLG------YKavGIRLDSGDLAYLSLEARKFFRtiee 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 300 QLGIDPLSKTLIFSDNLDFAKAIELYRHFADRVKlGFGIGTRL-TCdipHVKP-LNIVIKLVECNGRPVAKLSDSPGK-T 376
Cdd:PLN02885 340 ELGVPGFGKMSITASNDINEETLDALNKQGHEID-AFGIGTHLvTC---YAQPaLGCVYKLVEINGQPRIKLSEDVEKvT 415
|
....*...
gi 506220961 377 I-CHDKAF 383
Cdd:PLN02885 416 IpCKKRCY 423
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
200-368 |
1.71e-03 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 39.95 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 200 GTSNYDLARRLSLTPMGTQAHEWFQAHQqispdlaNSQIAALQAWLDEYP-DMLGIALTD----CITMD-AFLRDFGPef 273
Cdd:cd01571 140 GVSTVLGAELLGEKPSGTMPHALIQIFG-------GDQVEAWKAFDETYPeDVPRIALIDtfndEKEEAlKAAKALGD-- 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220961 274 agRYQGLRHD-SGDP----------VQWgEKAIAHYQQLGIdplsktlIFSDNLDFAKAIELYRHFADrvklGFGIGTRl 342
Cdd:cd01571 211 --KLDGVRLDtPSSRrgvfrylireVRW-ALDIRGYKHVKI-------FVSGGLDEEDIKELEDVGVD----AFGVGTA- 275
|
170 180
....*....|....*....|....*.
gi 506220961 343 tcdIPHVKPLNIVIKLVECNGRPVAK 368
Cdd:cd01571 276 ---ISKAPPVDFTMDIVEVNGQPIAK 298
|
|
| |
