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Concise Results
Standard Results
Full Results
formate C-acetyltransferase [Cronobacter turicensis]
Protein Classification
formate acetyltransferase ( domain architecture ID 10109346 )
formate acetyltransferase catalyzes the conversion of acetyl-CoA and formate to CoA and pyruvate
List of domain hits
Name
Accession
Description
Interval
E-value
PFL1
cd01678 Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, ...
11-756
0e+00
Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. The PFL mechanism involves an unusual radical cleavage of pyruvate in which two cysteines and one glycine form radicals that are required for catalysis. PFL has a ten-stranded alpha/beta barrel domain that is structurally similar to those of all three ribonucleotide reductase (RNR) classes as well as benzylsuccinate synthase and B12-independent glycerol dehydratase.
Pssm-ID: 153087 [Multi-domain]
Cd Length: 738
Bit Score: 1486.47
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 11 AWEGF AK G D WQ N E VN VRDFIQKNYTPYEGDESFLAG A TE A T TS LWDK VM E GVKL E NRTHAPV D F DT SVA STITSH D AGYI 90
Cdd:cd01678 1 AWEGF KG G K WQ E E ID VRDFIQKNYTPYEGDESFLAG P TE R T KK LWDK LE E LLEE E RAKGGVL D V DT KTV STITSH K AGYI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 91 N K T LE K IVGLQT EA PLKRAI I PFGGI K M V E GSC KAY NR ELDP Q LKKIFT E YRKTHN Q GVFD V YT KD I LNC R K SG VL TGLP 170
Cdd:cd01678 81 D K E LE V IVGLQT DK PLKRAI M PFGGI R M A E QAL KAY GY ELDP E LKKIFT K YRKTHN D GVFD A YT PE I RRA R H SG II TGLP 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 171 DAYGRGRIIGDYRRVALYG I D F LI KD K YAQFVS L QS D LE ngvn LEA TIRLREE I AEQ HR AL GQI K E MAA K YG C DIS G PAT 250
Cdd:cd01678 161 DAYGRGRIIGDYRRVALYG V D R LI EE K KKDLDN L GG D EM ---- TDD TIRLREE V AEQ IK AL KEL K Q MAA S YG L DIS R PAT 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 251 NAQEA V QWTYFGYLAA V K S QNGAAMS F GRVSTFLD V YIERDLKAG KLN E Q EAQELID HLV MKLRMVRFLRTPEY D ELFSG 330
Cdd:cd01678 237 NAQEA I QWTYFGYLAA I K E QNGAAMS L GRVSTFLD I YIERDLKAG TIT E A EAQELID QFI MKLRMVRFLRTPEY N ELFSG 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 331 DP I W A TES V GGMG V DGR T LVTK N SFRFLNTLY TM GP S PEPN I T I LWSEKLP L NFK K F A AKVSIDTSS L QYENDDLMRPD F 410
Cdd:cd01678 317 DP T W V TES I GGMG N DGR S LVTK T SFRFLNTLY NL GP A PEPN L T V LWSEKLP E NFK R F C AKVSIDTSS I QYENDDLMRPD W 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 411 NN DDY A IACCVS P M VV GKQMQFFGARANLAK TM LYAINGG V DEK LKM QVGP KSA PI KG D L L NF DEVME RM D HF MDWLA KQ 490
Cdd:cd01678 397 GG DDY G IACCVS A M RI GKQMQFFGARANLAK AL LYAINGG R DEK TGD QVGP DIE PI TS D Y L DY DEVME NY D KS MDWLA DT 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 491 YV T ALNIIHYMHDKY S YEA SL MALHD R DV I RTMA C GIAGLSVAADSLSAIKYAKVKPIRDEDGLA I DFEIEG EY P QF GN N 570
Cdd:cd01678 477 YV N ALNIIHYMHDKY A YEA LQ MALHD T DV R RTMA F GIAGLSVAADSLSAIKYAKVKPIRDEDGLA V DFEIEG DF P RY GN D 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 571 D A R V DD L AV DL V ER FM K K IQQL KTYRNA I PTQSVLTITSNVVYGKKTGNTPDGRRAG A PF G PGANPMHGRD Q KGA V ASL T 650
Cdd:cd01678 557 D D R A DD I AV WV V KT FM N K LRKH KTYRNA E PTQSVLTITSNVVYGKKTGNTPDGRRAG E PF A PGANPMHGRD K KGA L ASL A 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 651 SVAKLP FAY A K DGIS Y TFSIVPNALGK D DE V R KT NL A G LM DGYF HH easie GG Q HLNVNV M NRE M LLDAMEHPEKYPQLT 730
Cdd:cd01678 637 SVAKLP YRD A N DGIS N TFSIVPNALGK T DE E R ID NL V G IL DGYF TK ----- GG H HLNVNV L NRE T LLDAMEHPEKYPQLT 711
730 740
....*....|....*....|....*.
gi 506220934 731 IRVSGYAV R F NS LT K EQQ Q DVI T RTF 756
Cdd:cd01678 712 IRVSGYAV N F VK LT R EQQ L DVI S RTF 737
Name
Accession
Description
Interval
E-value
PFL1
cd01678 Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, ...
11-756
0e+00
Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. The PFL mechanism involves an unusual radical cleavage of pyruvate in which two cysteines and one glycine form radicals that are required for catalysis. PFL has a ten-stranded alpha/beta barrel domain that is structurally similar to those of all three ribonucleotide reductase (RNR) classes as well as benzylsuccinate synthase and B12-independent glycerol dehydratase.
Pssm-ID: 153087 [Multi-domain]
Cd Length: 738
Bit Score: 1486.47
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 11 AWEGF AK G D WQ N E VN VRDFIQKNYTPYEGDESFLAG A TE A T TS LWDK VM E GVKL E NRTHAPV D F DT SVA STITSH D AGYI 90
Cdd:cd01678 1 AWEGF KG G K WQ E E ID VRDFIQKNYTPYEGDESFLAG P TE R T KK LWDK LE E LLEE E RAKGGVL D V DT KTV STITSH K AGYI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 91 N K T LE K IVGLQT EA PLKRAI I PFGGI K M V E GSC KAY NR ELDP Q LKKIFT E YRKTHN Q GVFD V YT KD I LNC R K SG VL TGLP 170
Cdd:cd01678 81 D K E LE V IVGLQT DK PLKRAI M PFGGI R M A E QAL KAY GY ELDP E LKKIFT K YRKTHN D GVFD A YT PE I RRA R H SG II TGLP 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 171 DAYGRGRIIGDYRRVALYG I D F LI KD K YAQFVS L QS D LE ngvn LEA TIRLREE I AEQ HR AL GQI K E MAA K YG C DIS G PAT 250
Cdd:cd01678 161 DAYGRGRIIGDYRRVALYG V D R LI EE K KKDLDN L GG D EM ---- TDD TIRLREE V AEQ IK AL KEL K Q MAA S YG L DIS R PAT 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 251 NAQEA V QWTYFGYLAA V K S QNGAAMS F GRVSTFLD V YIERDLKAG KLN E Q EAQELID HLV MKLRMVRFLRTPEY D ELFSG 330
Cdd:cd01678 237 NAQEA I QWTYFGYLAA I K E QNGAAMS L GRVSTFLD I YIERDLKAG TIT E A EAQELID QFI MKLRMVRFLRTPEY N ELFSG 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 331 DP I W A TES V GGMG V DGR T LVTK N SFRFLNTLY TM GP S PEPN I T I LWSEKLP L NFK K F A AKVSIDTSS L QYENDDLMRPD F 410
Cdd:cd01678 317 DP T W V TES I GGMG N DGR S LVTK T SFRFLNTLY NL GP A PEPN L T V LWSEKLP E NFK R F C AKVSIDTSS I QYENDDLMRPD W 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 411 NN DDY A IACCVS P M VV GKQMQFFGARANLAK TM LYAINGG V DEK LKM QVGP KSA PI KG D L L NF DEVME RM D HF MDWLA KQ 490
Cdd:cd01678 397 GG DDY G IACCVS A M RI GKQMQFFGARANLAK AL LYAINGG R DEK TGD QVGP DIE PI TS D Y L DY DEVME NY D KS MDWLA DT 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 491 YV T ALNIIHYMHDKY S YEA SL MALHD R DV I RTMA C GIAGLSVAADSLSAIKYAKVKPIRDEDGLA I DFEIEG EY P QF GN N 570
Cdd:cd01678 477 YV N ALNIIHYMHDKY A YEA LQ MALHD T DV R RTMA F GIAGLSVAADSLSAIKYAKVKPIRDEDGLA V DFEIEG DF P RY GN D 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 571 D A R V DD L AV DL V ER FM K K IQQL KTYRNA I PTQSVLTITSNVVYGKKTGNTPDGRRAG A PF G PGANPMHGRD Q KGA V ASL T 650
Cdd:cd01678 557 D D R A DD I AV WV V KT FM N K LRKH KTYRNA E PTQSVLTITSNVVYGKKTGNTPDGRRAG E PF A PGANPMHGRD K KGA L ASL A 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 651 SVAKLP FAY A K DGIS Y TFSIVPNALGK D DE V R KT NL A G LM DGYF HH easie GG Q HLNVNV M NRE M LLDAMEHPEKYPQLT 730
Cdd:cd01678 637 SVAKLP YRD A N DGIS N TFSIVPNALGK T DE E R ID NL V G IL DGYF TK ----- GG H HLNVNV L NRE T LLDAMEHPEKYPQLT 711
730 740
....*....|....*....|....*.
gi 506220934 731 IRVSGYAV R F NS LT K EQQ Q DVI T RTF 756
Cdd:cd01678 712 IRVSGYAV N F VK LT R EQQ L DVI S RTF 737
pyr_form_ly_1
TIGR01255 formate acetyltransferase 1; Alternate names: pyruvate formate-lyase; formate ...
11-760
0e+00
formate acetyltransferase 1; Alternate names: pyruvate formate-lyase; formate C-acetyltransferase This enzyme converts formate + acetyl-CoA into pyruvate + CoA. This model describes formate acetyltransferase 1. More distantly related putative formate acetyltransferases have also been identified, including formate acetyltransferase 2 from E. coli, which is excluded from this model. [Energy metabolism, Fermentation]
Pssm-ID: 273525 [Multi-domain]
Cd Length: 744
Bit Score: 1394.65
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 11 AWEGF A KGDWQNEVNVRDFIQKNY T PYEGDESFLAG A TEATT SL WDKVME g VKLENRTHAPVDFDT S VASTITSHDAGYI 90
Cdd:TIGR01255 1 AWEGF T KGDWQNEVNVRDFIQKNY K PYEGDESFLAG P TEATT KV WDKVME - VKLENRTHAPVDFDT A VASTITSHDAGYI 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 91 N K T LEKIVGLQTEAPLKRA I IPFGGI K M V EGS C K A Y N RELDP QLK KIFTEYRKTHNQGVFD V YT K DI LNC RK S GVLTGLP 170
Cdd:TIGR01255 80 D K Q LEKIVGLQTEAPLKRA L IPFGGI R M A EGS L K E Y G RELDP MIH KIFTEYRKTHNQGVFD A YT P DI RRA RK A GVLTGLP 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 171 DAYGRGRIIGDYRRVALYGID F L I K D K YA QF V SLQ S DLEN gvnle AT IRLREEIAEQHRALG QI KEMAAKYG C DIS G PAT 250
Cdd:TIGR01255 160 DAYGRGRIIGDYRRVALYGID Y L M K E K LK QF T SLQ A DLEN ----- EL IRLREEIAEQHRALG EM KEMAAKYG Y DIS R PAT 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 251 NA Q EA V QWTYFGYLAAVKSQNGAAMS F GR V STFLD V YIERDLKAGK LN EQEAQE LI DH L VMKLRMVRFLRTPEYDELFSG 330
Cdd:TIGR01255 235 NA K EA I QWTYFGYLAAVKSQNGAAMS L GR T STFLD I YIERDLKAGK IT EQEAQE MV DH F VMKLRMVRFLRTPEYDELFSG 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 331 DP I WATES VG GMG V DGRTLVTKNSFRFLNTLYTMGP S PEPN I T I LWSEKLPL N FKKFAAK V SIDTSS L QYENDDLMRPDF 410
Cdd:TIGR01255 315 DP T WATES IA GMG L DGRTLVTKNSFRFLNTLYTMGP A PEPN M T V LWSEKLPL S FKKFAAK M SIDTSS I QYENDDLMRPDF 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 411 NNDDYAIACCVSPM V VGKQMQFFGARANLAKTMLYAINGGVDEKLKMQV G P KSA PIK GDL L NF DEVME R MD H F M DWLAKQ 490
Cdd:TIGR01255 395 NNDDYAIACCVSPM I VGKQMQFFGARANLAKTMLYAINGGVDEKLKMQV V P DIE PIK DEV L DY DEVME N MD K F L DWLAKQ 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 491 YVTA L NIIHYMHDKYSYEAS L MALHD RD VIRTMA C GIAG L SVAADSLSAIKYAKVKPIRDE D GLAIDFEIEG EY PQ F GN N 570
Cdd:TIGR01255 475 YVTA M NIIHYMHDKYSYEAS Q MALHD TK VIRTMA F GIAG F SVAADSLSAIKYAKVKPIRDE N GLAIDFEIEG DF PQ Y GN D 554
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 571 D A RVDD L AVDLVERFMKK I Q QLK TYRNAIPTQSVLTITSNVVYGKKTGNTPDGRR A GAPFGPGANPMHGRDQKGA V ASLT 650
Cdd:TIGR01255 555 D D RVDD I AVDLVERFMKK L Q KHH TYRNAIPTQSVLTITSNVVYGKKTGNTPDGRR V GAPFGPGANPMHGRDQKGA L ASLT 634
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 651 SVAKLPFAYAKDGISYTFSIVPNALGKDD E VRKTNL A G L MDGYFHHEASIEGGQHLNVNVMNREMLLDAME H PEKYPQLT 730
Cdd:TIGR01255 635 SVAKLPFAYAKDGISYTFSIVPNALGKDD D VRKTNL V G I MDGYFHHEASIEGGQHLNVNVMNREMLLDAME N PEKYPQLT 714
730 740 750
....*....|....*....|....*....|
gi 506220934 731 IRVSGYAV R FNSLTKEQQQ D VITRTF TQTM 760
Cdd:TIGR01255 715 IRVSGYAV N FNSLTKEQQQ E VITRTF HESL 744
PflD
COG1882 Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of ...
41-756
0e+00
Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 441486 [Multi-domain]
Cd Length: 789
Bit Score: 1045.89
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 41 ESFLAG A TE A T TS L WD K VM E GVK L -------------- E NRTHAPVDFDTSVA S T I TS H DAG YI n K TL E K IVGLQT EA P L 106
Cdd:COG1882 1 ESFLAG P TE R T KR L RE K LL E AKP L idierarlftesyk E TEGLPVIIRRAKAF S H I LE H KPI YI - K DD E L IVGLQT DK P R 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 107 KR A I I P F GGI KM VE GSCK A YNR ------ E LD P QL K K IF T E Y ----- R KTHN Q GVFD V Y TKD I LNC RK S G VL TGLPDAYGR 175
Cdd:COG1882 80 KR P I F P E GGI RW VE DELD A LPT rpqdgf E IS P ED K E IF R E I apywk G KTHN D GVFD A Y PEE I RKA RK A G II TGLPDAYGR 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 176 G R IIGDYRRV A LYG I D F LI KDKYAQFVS L - QS D L E NG ---------- VNL EA T IRL R E EI AE QH R A L ---------- GQI 234
Cdd:COG1882 160 G H IIGDYRRV L LYG L D G LI EEAKEKLAE L d LT D P E DI ekidfykami IVC EA V IRL A E RY AE LA R E L aeketdpkrk AEL 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 235 K E M A AKY G CDISG PA TNAQ EAVQW TY F G YLAA V K S QNGAAMS F GR VSTF L DV Y I ERDL KA G K L N E Q EAQEL I D HLVM KLR 314
Cdd:COG1882 240 L E I A EIC G FVPAN PA RTFW EAVQW VW F V YLAA I K E QNGAAMS L GR FDQY L YP Y Y ERDL EE G R L T E E EAQEL L D CFWI KLR 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 315 M VRFLRTPEY D ELF S G D P I W A T ESV GGM GV DGR TL V TKN S FRF L N TL YTM g P S PEPN I T IL WSEKLP LN F K K F AA K - V SI 393
Cdd:COG1882 320 E VRFLRTPEY A ELF A G Y P T W V T LTI GGM TP DGR DA V NEL S YLI L E TL RNL - P L PEPN L T VR WSEKLP EG F L K K AA E v I SI 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 394 D T S S L QYENDDLM R P DFN N -------- D DY A IA C CV S PMV V GKQMQFFGA - R A NLAK TML YA I N G GVDEK LKM QVGP KSA 464
Cdd:COG1882 399 G T G S P QYENDDLM I P MLL N kgvtleda R DY G IA G CV E PMV P GKQMQFFGA g R I NLAK ALE YA L N N GVDEK TGK QVGP ETG 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 465 PIK g D L L NF DEVME RMDHFM D W LA KQ YV T ALNIIHYMHDKY SY E AS L M ALHD RDVI R TM ------------ A C GIAGLSV 532
Cdd:COG1882 479 DPT - D F L TY DEVME AFKKQL D Y LA DL YV N ALNIIHYMHDKY AP E PF L S ALHD DCIE R GK dlneggarynfg A I GIAGLSV 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 533 A ADSLSAIK --- YA K V K PIR DE -- DG LA ID FE ------- IEGEY P QF GN N D AR VD DL AV D LVE R FM KK I QQL KTYR NAIP 600
Cdd:COG1882 558 V ADSLSAIK klv FD K K K VTM DE ll EA LA AN FE gyeelrq LLLNA P KY GN D D DY VD EI AV E LVE T FM DE I RKY KTYR GGTY 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 601 T Q S V LTITSNV V YGKKTG N TPDGR R AG A P FGP GA N PMHGRD QK G AV A S L T SVAKLP FAY A K DGI SYTFSIV P N ALG KDD e 680
Cdd:COG1882 638 T L S I LTITSNV P YGKKTG A TPDGR K AG E P LAD GA S PMHGRD KN G PT A V L K SVAKLP YEK A T DGI LLNQKFS P S ALG GEE - 716
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506220934 681 v RKT NL AG L MDG YF HH easie GG Q H LNV NV MN RE M LLDA ME HPEKYP Q LT I RV S GY AVR F NS L T KEQQ Q D V I T RT F 756
Cdd:COG1882 717 - GIE NL VS L LRT YF DL ----- GG H H IQF NV VD RE T LLDA QK HPEKYP D LT V RV A GY SAY F VE L S KEQQ D D I I A RT E 786
PFL-like
pfam02901 Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline ...
30-614
0e+00
Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline trimethylamine lyase, glycerol dehydratase, 4-hydroxyphenylacetate decarboxylase, and benzylsuccinate synthase.
Pssm-ID: 427048
Cd Length: 647
Bit Score: 751.77
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 30 IQK NYT P Y E GD E S FL agateattsl W DKVMEGVKLENR T HAPVDF D TSV A ST --- I T SH DA GYI n KTL E K IVGLQT EA P L 106
Cdd:pfam02901 8 LKE NYT L Y T GD P S LS ---------- W ERARLLTESYKE T EGVLPV D IRR A KA lkk I L SH LP GYI - RDD E L IVGLQT DK P R 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 107 KRAI I P F GGI KM VE ------ GSCKAYNR E LDPQL KKIF T E ----- YR KTHN Q GVFD V YT KDILNC R K SG VL TGLPDAYGR 175
Cdd:pfam02901 77 KRAI Y P E GGI RW VE deldyl NTRPQDGF E ISEED KKIF R E ifpyw KG KTHN E GVFD A YT PEMKAA R E SG IF TGLPDAYGR 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 176 G R IIGDYRRV A LYG I D F LI KD K YAQFVS L QS D L E N --------------- G V NL -- E ATI RL R EE I AEQ H --- RALGQIK 235
Cdd:pfam02901 157 G H IIGDYRRV L LYG L D G LI EE K EEKLAK L DT D P E D iekiefykamiiscd A V IE ya E RYA RL A EE L AEQ E tdp KRKAELL 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 236 E M A AKY G CDISG PA TNA QEA V QW TY F G YLAAVK S QNGAAMS F GR VSTF L DV Y I ERDL KA G K L N E Q EAQELID HLVM KLR M 315
Cdd:pfam02901 237 E I A EIC G RVPAR PA ETF QEA I QW FW F V YLAAVK E QNGAAMS L GR LDQY L YP Y Y ERDL EE G R L T E E EAQELID CFWI KLR E 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 316 VRFLRTPEY DE LF S G DPIWATESV GG M G V DGR TL V T K N S FRF L NT L YTM g P S PEPN I T IL WS E KLP LN F K K F AA K VS ID - 394
Cdd:pfam02901 317 VRFLRTPEY NK LF A G YDPFQNLTI GG Q G R DGR DA V N K L S YLI L EA L DNL - P L PEPN L T VR WS K KLP EE F L K K AA E VS RK g 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 395 T S S L QYENDD L M R P DFN N D -------- DY A IA C CV S PM VV GK Q MQFFGAR A NLAK TML YA I NGG V DE KLKM QVGPK SA P I 466
Cdd:pfam02901 396 T G S P QYENDD V M I P ALL N R gvsledar DY G IA G CV E PM KP GK E MQFFGAR I NLAK ALE YA L NGG R DE LTGK QVGPK TG P V 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 467 K g DL L N F D EVME RMDHFM D W LA KQ YV T ALNIIHYMHDKY SY E AS L M ALHD RDVI R TMAC GI ------------ AGL SVA A 534
Cdd:pfam02901 476 T - EF L S F E EVME AFKKQL D Y LA DL YV N ALNIIHYMHDKY AP E PF L S ALHD DCIE R GKDV GI ggarynfsgpqg AGL ANV A 554
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 535 DSLSAIK Y ---- A KV KPI R D - ED G LA I DFE I E G E -------- Y P QF GN N D A RVDD L AV DL VE R FM KKIQQL K T YR NAIP T 601
Cdd:pfam02901 555 DSLSAIK K lvfd D KV YTL R E l ED A LA A DFE G E E E lrqdllnd A P KY GN D D D RVDD I AV EV VE T FM DEVRKY K N YR GGKF T 634
650
....*....|...
gi 506220934 602 Q S V LTITSNV V YG 614
Cdd:pfam02901 635 P S L LTITSNV P YG 647
pflD
PRK09983 putative formate acetyltransferase 2; Provisional
174-758
5.70e-45
putative formate acetyltransferase 2; Provisional
Pssm-ID: 182181 [Multi-domain]
Cd Length: 765
Bit Score: 173.08
E-value: 5.70e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 174 G R G R II G DY R R VALY G IDF L I k DKYA Q FVSL Q SDLE ---- NGVN LEA TIR ------- L R E EI A E ----- Q H R A lg QIKEM 237
Cdd:PRK09983 153 G Q G H II I DY P R LLNH G LGE L V - AQMQ Q HCQQ Q PENH fyqa ALLL LEA SQK hilryae L A E TM A A nctda Q R R E -- ELLTI 229
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 238 A AKYGCDISGPATNAQE A V Q WTYFGYLAAVKSQ N GAAM S F GR VSTFLDVYIERD L KA G K l NEQEAQ EL IDH L VM K LRMVR 317
Cdd:PRK09983 230 A EISRHNAQHKPQTFWQ A C Q LFWYMNIILQYES N ASSL S L GR FDQYMLPFYQAS L TQ G E - DPAFLK EL LES L WV K CNDIV 308
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 318 F LR TPEYDEL F S G D P IWA T ESV GG MGVD GR TL V TKN SF RF L NT l Y TMGPS P E PN ITILWSEKLPLN F - K K F A AKVSID T S 396
Cdd:PRK09983 309 L LR STSSARY F A G F P TGY T ALL GG LTEN GR SA V NVL SF LC L DA - Y QSVQL P Q PN LGVRTNALIDTP F l M K T A ETIRLG T G 387
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 397 SL Q YE ND DLMR P D F N N D -------- DY AIAC CV SPMVV G KQ mqf F G ---- A RA NL A K T M lyainggvd E KLKMQVGPKS A 464
Cdd:PRK09983 388 IP Q IF ND EVVV P A F L N R gvsledar DY SVVG CV ELSIP G RT --- Y G lhdi A MF NL L K V M --------- E ICLHENEGNA A 455
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 465 PIKGD LL nf DEVMERMD H FM dwla KQY V TAL NI IHYM H DKYSYEAS L MAL ------ HD RD VI ---- R TMAC G IA G LSV A - 533
Cdd:PRK09983 456 LTYEG LL -- EQIRAKIS H YI ---- TLM V EGS NI CDIG H RDWAPVPL L SSF isdcle KG RD IT dgga R YNFS G VQ G IGI A n 529
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 534 - A DSL S A I K yakv KPIR D EDG L AI D FEI ---------- EGE --------- YPQF GN NDAR VD DLAVD L VERFM K KIQQLK 593
Cdd:PRK09983 530 l S DSL H A L K ---- GMVF D QQR L SF D ELL svlkanfatp EGE kvrarlinr FEKY GN DIDE VD NISAE L LRHYC K EVEKYQ 605
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 594 TY R NAIP T QSVL T ITSN V VY G KKT G N TPDGR R AG APFGP G A - N PM H G R D QK G AV A S L T SV A KL PFAYAKD G ISYTFSIV P 672
Cdd:PRK09983 606 NP R GGYF T PGSY T VSAH V PL G SVV G A TPDGR F AG EQLAD G G l S PM L G Q D AQ G PT A V L K SV S KL DNTLLSN G TLLNVKFT P 685
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 673 NA L GKDDEV RK tn LA GLMDGYFHHEA siegg QH LNV NV M N REM L LD A MEH P EK Y PQ L TI RV S GY AVR F NS L T KE Q Q Q D V I 752
Cdd:PRK09983 686 AT L EGEAGL RK -- LA DFLRAFTQLKL ----- QH IQF NV V N ADT L RE A QQR P QD Y AG L VV RV A GY SAF F VE L S KE I Q D D I I 758
....*.
gi 506220934 753 T RT FT Q 758
Cdd:PRK09983 759 R RT AH Q 764
rad_fix_GrcA3
NF038360 autonomous glycyl radical cofactor GrcA3; This small protein, like GrcA and GrcA2, is a ...
685-760
1.53e-34
autonomous glycyl radical cofactor GrcA3; This small protein, like GrcA and GrcA2, is a lineage-specific small protein related to the glycyl radical active site-containing C-terminal region of pyruvate formate-lyase (PFL, also called formate C-acetyltransferase) from similar species. Because PFL is prone to damage and inactivation, this protein is made as a spare part that fills in for the portion of the protein that was damaged and lost. The distinct families we now call GrcA, GrcA2, and GrcA3 all have the surprising property of being much more closely related to some full length PFL than to members of the other GrcA-series families.
Pssm-ID: 439653 [Multi-domain]
Cd Length: 78
Bit Score: 126.01
E-value: 1.53e-34
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506220934 685 NL AG L M DGY fhhea SIE GG Q HLNVNV M NRE M LLDA ME HPEKYPQLT I RVSGYAV R FN S LTKEQQ QD VI T RTF TQT M 760
Cdd:NF038360 8 NL VS L L DGY ----- AEK GG H HLNVNV F NRE T LLDA QA HPEKYPQLT V RVSGYAV N FN K LTKEQQ DE VI S RTF HEA M 78
Name
Accession
Description
Interval
E-value
PFL1
cd01678 Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, ...
11-756
0e+00
Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. The PFL mechanism involves an unusual radical cleavage of pyruvate in which two cysteines and one glycine form radicals that are required for catalysis. PFL has a ten-stranded alpha/beta barrel domain that is structurally similar to those of all three ribonucleotide reductase (RNR) classes as well as benzylsuccinate synthase and B12-independent glycerol dehydratase.
Pssm-ID: 153087 [Multi-domain]
Cd Length: 738
Bit Score: 1486.47
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 11 AWEGF AK G D WQ N E VN VRDFIQKNYTPYEGDESFLAG A TE A T TS LWDK VM E GVKL E NRTHAPV D F DT SVA STITSH D AGYI 90
Cdd:cd01678 1 AWEGF KG G K WQ E E ID VRDFIQKNYTPYEGDESFLAG P TE R T KK LWDK LE E LLEE E RAKGGVL D V DT KTV STITSH K AGYI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 91 N K T LE K IVGLQT EA PLKRAI I PFGGI K M V E GSC KAY NR ELDP Q LKKIFT E YRKTHN Q GVFD V YT KD I LNC R K SG VL TGLP 170
Cdd:cd01678 81 D K E LE V IVGLQT DK PLKRAI M PFGGI R M A E QAL KAY GY ELDP E LKKIFT K YRKTHN D GVFD A YT PE I RRA R H SG II TGLP 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 171 DAYGRGRIIGDYRRVALYG I D F LI KD K YAQFVS L QS D LE ngvn LEA TIRLREE I AEQ HR AL GQI K E MAA K YG C DIS G PAT 250
Cdd:cd01678 161 DAYGRGRIIGDYRRVALYG V D R LI EE K KKDLDN L GG D EM ---- TDD TIRLREE V AEQ IK AL KEL K Q MAA S YG L DIS R PAT 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 251 NAQEA V QWTYFGYLAA V K S QNGAAMS F GRVSTFLD V YIERDLKAG KLN E Q EAQELID HLV MKLRMVRFLRTPEY D ELFSG 330
Cdd:cd01678 237 NAQEA I QWTYFGYLAA I K E QNGAAMS L GRVSTFLD I YIERDLKAG TIT E A EAQELID QFI MKLRMVRFLRTPEY N ELFSG 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 331 DP I W A TES V GGMG V DGR T LVTK N SFRFLNTLY TM GP S PEPN I T I LWSEKLP L NFK K F A AKVSIDTSS L QYENDDLMRPD F 410
Cdd:cd01678 317 DP T W V TES I GGMG N DGR S LVTK T SFRFLNTLY NL GP A PEPN L T V LWSEKLP E NFK R F C AKVSIDTSS I QYENDDLMRPD W 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 411 NN DDY A IACCVS P M VV GKQMQFFGARANLAK TM LYAINGG V DEK LKM QVGP KSA PI KG D L L NF DEVME RM D HF MDWLA KQ 490
Cdd:cd01678 397 GG DDY G IACCVS A M RI GKQMQFFGARANLAK AL LYAINGG R DEK TGD QVGP DIE PI TS D Y L DY DEVME NY D KS MDWLA DT 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 491 YV T ALNIIHYMHDKY S YEA SL MALHD R DV I RTMA C GIAGLSVAADSLSAIKYAKVKPIRDEDGLA I DFEIEG EY P QF GN N 570
Cdd:cd01678 477 YV N ALNIIHYMHDKY A YEA LQ MALHD T DV R RTMA F GIAGLSVAADSLSAIKYAKVKPIRDEDGLA V DFEIEG DF P RY GN D 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 571 D A R V DD L AV DL V ER FM K K IQQL KTYRNA I PTQSVLTITSNVVYGKKTGNTPDGRRAG A PF G PGANPMHGRD Q KGA V ASL T 650
Cdd:cd01678 557 D D R A DD I AV WV V KT FM N K LRKH KTYRNA E PTQSVLTITSNVVYGKKTGNTPDGRRAG E PF A PGANPMHGRD K KGA L ASL A 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 651 SVAKLP FAY A K DGIS Y TFSIVPNALGK D DE V R KT NL A G LM DGYF HH easie GG Q HLNVNV M NRE M LLDAMEHPEKYPQLT 730
Cdd:cd01678 637 SVAKLP YRD A N DGIS N TFSIVPNALGK T DE E R ID NL V G IL DGYF TK ----- GG H HLNVNV L NRE T LLDAMEHPEKYPQLT 711
730 740
....*....|....*....|....*.
gi 506220934 731 IRVSGYAV R F NS LT K EQQ Q DVI T RTF 756
Cdd:cd01678 712 IRVSGYAV N F VK LT R EQQ L DVI S RTF 737
pyr_form_ly_1
TIGR01255 formate acetyltransferase 1; Alternate names: pyruvate formate-lyase; formate ...
11-760
0e+00
formate acetyltransferase 1; Alternate names: pyruvate formate-lyase; formate C-acetyltransferase This enzyme converts formate + acetyl-CoA into pyruvate + CoA. This model describes formate acetyltransferase 1. More distantly related putative formate acetyltransferases have also been identified, including formate acetyltransferase 2 from E. coli, which is excluded from this model. [Energy metabolism, Fermentation]
Pssm-ID: 273525 [Multi-domain]
Cd Length: 744
Bit Score: 1394.65
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 11 AWEGF A KGDWQNEVNVRDFIQKNY T PYEGDESFLAG A TEATT SL WDKVME g VKLENRTHAPVDFDT S VASTITSHDAGYI 90
Cdd:TIGR01255 1 AWEGF T KGDWQNEVNVRDFIQKNY K PYEGDESFLAG P TEATT KV WDKVME - VKLENRTHAPVDFDT A VASTITSHDAGYI 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 91 N K T LEKIVGLQTEAPLKRA I IPFGGI K M V EGS C K A Y N RELDP QLK KIFTEYRKTHNQGVFD V YT K DI LNC RK S GVLTGLP 170
Cdd:TIGR01255 80 D K Q LEKIVGLQTEAPLKRA L IPFGGI R M A EGS L K E Y G RELDP MIH KIFTEYRKTHNQGVFD A YT P DI RRA RK A GVLTGLP 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 171 DAYGRGRIIGDYRRVALYGID F L I K D K YA QF V SLQ S DLEN gvnle AT IRLREEIAEQHRALG QI KEMAAKYG C DIS G PAT 250
Cdd:TIGR01255 160 DAYGRGRIIGDYRRVALYGID Y L M K E K LK QF T SLQ A DLEN ----- EL IRLREEIAEQHRALG EM KEMAAKYG Y DIS R PAT 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 251 NA Q EA V QWTYFGYLAAVKSQNGAAMS F GR V STFLD V YIERDLKAGK LN EQEAQE LI DH L VMKLRMVRFLRTPEYDELFSG 330
Cdd:TIGR01255 235 NA K EA I QWTYFGYLAAVKSQNGAAMS L GR T STFLD I YIERDLKAGK IT EQEAQE MV DH F VMKLRMVRFLRTPEYDELFSG 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 331 DP I WATES VG GMG V DGRTLVTKNSFRFLNTLYTMGP S PEPN I T I LWSEKLPL N FKKFAAK V SIDTSS L QYENDDLMRPDF 410
Cdd:TIGR01255 315 DP T WATES IA GMG L DGRTLVTKNSFRFLNTLYTMGP A PEPN M T V LWSEKLPL S FKKFAAK M SIDTSS I QYENDDLMRPDF 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 411 NNDDYAIACCVSPM V VGKQMQFFGARANLAKTMLYAINGGVDEKLKMQV G P KSA PIK GDL L NF DEVME R MD H F M DWLAKQ 490
Cdd:TIGR01255 395 NNDDYAIACCVSPM I VGKQMQFFGARANLAKTMLYAINGGVDEKLKMQV V P DIE PIK DEV L DY DEVME N MD K F L DWLAKQ 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 491 YVTA L NIIHYMHDKYSYEAS L MALHD RD VIRTMA C GIAG L SVAADSLSAIKYAKVKPIRDE D GLAIDFEIEG EY PQ F GN N 570
Cdd:TIGR01255 475 YVTA M NIIHYMHDKYSYEAS Q MALHD TK VIRTMA F GIAG F SVAADSLSAIKYAKVKPIRDE N GLAIDFEIEG DF PQ Y GN D 554
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 571 D A RVDD L AVDLVERFMKK I Q QLK TYRNAIPTQSVLTITSNVVYGKKTGNTPDGRR A GAPFGPGANPMHGRDQKGA V ASLT 650
Cdd:TIGR01255 555 D D RVDD I AVDLVERFMKK L Q KHH TYRNAIPTQSVLTITSNVVYGKKTGNTPDGRR V GAPFGPGANPMHGRDQKGA L ASLT 634
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 651 SVAKLPFAYAKDGISYTFSIVPNALGKDD E VRKTNL A G L MDGYFHHEASIEGGQHLNVNVMNREMLLDAME H PEKYPQLT 730
Cdd:TIGR01255 635 SVAKLPFAYAKDGISYTFSIVPNALGKDD D VRKTNL V G I MDGYFHHEASIEGGQHLNVNVMNREMLLDAME N PEKYPQLT 714
730 740 750
....*....|....*....|....*....|
gi 506220934 731 IRVSGYAV R FNSLTKEQQQ D VITRTF TQTM 760
Cdd:TIGR01255 715 IRVSGYAV N FNSLTKEQQQ E VITRTF HESL 744
PflD
COG1882 Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of ...
41-756
0e+00
Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 441486 [Multi-domain]
Cd Length: 789
Bit Score: 1045.89
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 41 ESFLAG A TE A T TS L WD K VM E GVK L -------------- E NRTHAPVDFDTSVA S T I TS H DAG YI n K TL E K IVGLQT EA P L 106
Cdd:COG1882 1 ESFLAG P TE R T KR L RE K LL E AKP L idierarlftesyk E TEGLPVIIRRAKAF S H I LE H KPI YI - K DD E L IVGLQT DK P R 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 107 KR A I I P F GGI KM VE GSCK A YNR ------ E LD P QL K K IF T E Y ----- R KTHN Q GVFD V Y TKD I LNC RK S G VL TGLPDAYGR 175
Cdd:COG1882 80 KR P I F P E GGI RW VE DELD A LPT rpqdgf E IS P ED K E IF R E I apywk G KTHN D GVFD A Y PEE I RKA RK A G II TGLPDAYGR 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 176 G R IIGDYRRV A LYG I D F LI KDKYAQFVS L - QS D L E NG ---------- VNL EA T IRL R E EI AE QH R A L ---------- GQI 234
Cdd:COG1882 160 G H IIGDYRRV L LYG L D G LI EEAKEKLAE L d LT D P E DI ekidfykami IVC EA V IRL A E RY AE LA R E L aeketdpkrk AEL 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 235 K E M A AKY G CDISG PA TNAQ EAVQW TY F G YLAA V K S QNGAAMS F GR VSTF L DV Y I ERDL KA G K L N E Q EAQEL I D HLVM KLR 314
Cdd:COG1882 240 L E I A EIC G FVPAN PA RTFW EAVQW VW F V YLAA I K E QNGAAMS L GR FDQY L YP Y Y ERDL EE G R L T E E EAQEL L D CFWI KLR 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 315 M VRFLRTPEY D ELF S G D P I W A T ESV GGM GV DGR TL V TKN S FRF L N TL YTM g P S PEPN I T IL WSEKLP LN F K K F AA K - V SI 393
Cdd:COG1882 320 E VRFLRTPEY A ELF A G Y P T W V T LTI GGM TP DGR DA V NEL S YLI L E TL RNL - P L PEPN L T VR WSEKLP EG F L K K AA E v I SI 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 394 D T S S L QYENDDLM R P DFN N -------- D DY A IA C CV S PMV V GKQMQFFGA - R A NLAK TML YA I N G GVDEK LKM QVGP KSA 464
Cdd:COG1882 399 G T G S P QYENDDLM I P MLL N kgvtleda R DY G IA G CV E PMV P GKQMQFFGA g R I NLAK ALE YA L N N GVDEK TGK QVGP ETG 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 465 PIK g D L L NF DEVME RMDHFM D W LA KQ YV T ALNIIHYMHDKY SY E AS L M ALHD RDVI R TM ------------ A C GIAGLSV 532
Cdd:COG1882 479 DPT - D F L TY DEVME AFKKQL D Y LA DL YV N ALNIIHYMHDKY AP E PF L S ALHD DCIE R GK dlneggarynfg A I GIAGLSV 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 533 A ADSLSAIK --- YA K V K PIR DE -- DG LA ID FE ------- IEGEY P QF GN N D AR VD DL AV D LVE R FM KK I QQL KTYR NAIP 600
Cdd:COG1882 558 V ADSLSAIK klv FD K K K VTM DE ll EA LA AN FE gyeelrq LLLNA P KY GN D D DY VD EI AV E LVE T FM DE I RKY KTYR GGTY 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 601 T Q S V LTITSNV V YGKKTG N TPDGR R AG A P FGP GA N PMHGRD QK G AV A S L T SVAKLP FAY A K DGI SYTFSIV P N ALG KDD e 680
Cdd:COG1882 638 T L S I LTITSNV P YGKKTG A TPDGR K AG E P LAD GA S PMHGRD KN G PT A V L K SVAKLP YEK A T DGI LLNQKFS P S ALG GEE - 716
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506220934 681 v RKT NL AG L MDG YF HH easie GG Q H LNV NV MN RE M LLDA ME HPEKYP Q LT I RV S GY AVR F NS L T KEQQ Q D V I T RT F 756
Cdd:COG1882 717 - GIE NL VS L LRT YF DL ----- GG H H IQF NV VD RE T LLDA QK HPEKYP D LT V RV A GY SAY F VE L S KEQQ D D I I A RT E 786
PFL-like
pfam02901 Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline ...
30-614
0e+00
Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline trimethylamine lyase, glycerol dehydratase, 4-hydroxyphenylacetate decarboxylase, and benzylsuccinate synthase.
Pssm-ID: 427048
Cd Length: 647
Bit Score: 751.77
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 30 IQK NYT P Y E GD E S FL agateattsl W DKVMEGVKLENR T HAPVDF D TSV A ST --- I T SH DA GYI n KTL E K IVGLQT EA P L 106
Cdd:pfam02901 8 LKE NYT L Y T GD P S LS ---------- W ERARLLTESYKE T EGVLPV D IRR A KA lkk I L SH LP GYI - RDD E L IVGLQT DK P R 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 107 KRAI I P F GGI KM VE ------ GSCKAYNR E LDPQL KKIF T E ----- YR KTHN Q GVFD V YT KDILNC R K SG VL TGLPDAYGR 175
Cdd:pfam02901 77 KRAI Y P E GGI RW VE deldyl NTRPQDGF E ISEED KKIF R E ifpyw KG KTHN E GVFD A YT PEMKAA R E SG IF TGLPDAYGR 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 176 G R IIGDYRRV A LYG I D F LI KD K YAQFVS L QS D L E N --------------- G V NL -- E ATI RL R EE I AEQ H --- RALGQIK 235
Cdd:pfam02901 157 G H IIGDYRRV L LYG L D G LI EE K EEKLAK L DT D P E D iekiefykamiiscd A V IE ya E RYA RL A EE L AEQ E tdp KRKAELL 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 236 E M A AKY G CDISG PA TNA QEA V QW TY F G YLAAVK S QNGAAMS F GR VSTF L DV Y I ERDL KA G K L N E Q EAQELID HLVM KLR M 315
Cdd:pfam02901 237 E I A EIC G RVPAR PA ETF QEA I QW FW F V YLAAVK E QNGAAMS L GR LDQY L YP Y Y ERDL EE G R L T E E EAQELID CFWI KLR E 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 316 VRFLRTPEY DE LF S G DPIWATESV GG M G V DGR TL V T K N S FRF L NT L YTM g P S PEPN I T IL WS E KLP LN F K K F AA K VS ID - 394
Cdd:pfam02901 317 VRFLRTPEY NK LF A G YDPFQNLTI GG Q G R DGR DA V N K L S YLI L EA L DNL - P L PEPN L T VR WS K KLP EE F L K K AA E VS RK g 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 395 T S S L QYENDD L M R P DFN N D -------- DY A IA C CV S PM VV GK Q MQFFGAR A NLAK TML YA I NGG V DE KLKM QVGPK SA P I 466
Cdd:pfam02901 396 T G S P QYENDD V M I P ALL N R gvsledar DY G IA G CV E PM KP GK E MQFFGAR I NLAK ALE YA L NGG R DE LTGK QVGPK TG P V 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 467 K g DL L N F D EVME RMDHFM D W LA KQ YV T ALNIIHYMHDKY SY E AS L M ALHD RDVI R TMAC GI ------------ AGL SVA A 534
Cdd:pfam02901 476 T - EF L S F E EVME AFKKQL D Y LA DL YV N ALNIIHYMHDKY AP E PF L S ALHD DCIE R GKDV GI ggarynfsgpqg AGL ANV A 554
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 535 DSLSAIK Y ---- A KV KPI R D - ED G LA I DFE I E G E -------- Y P QF GN N D A RVDD L AV DL VE R FM KKIQQL K T YR NAIP T 601
Cdd:pfam02901 555 DSLSAIK K lvfd D KV YTL R E l ED A LA A DFE G E E E lrqdllnd A P KY GN D D D RVDD I AV EV VE T FM DEVRKY K N YR GGKF T 634
650
....*....|...
gi 506220934 602 Q S V LTITSNV V YG 614
Cdd:pfam02901 635 P S L LTITSNV P YG 647
RNR_PFL
cd00576 Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ...
154-710
1.51e-90
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain]
Cd Length: 401
Bit Score: 289.82
E-value: 1.51e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 154 TKD I LNCR KSGV L T GLPDAY - GR G RIIG DY RRVALY GI DF likdkyaqfvslqsdlengvnleatirlreeiaeqhralg 232
Cdd:cd00576 1 AER I YEAV KSGV I T VGRPDL p FT G CVLV DY GDSLDP GI KG ---------------------------------------- 40
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 233 qikemaakygcd ISGP A TNAQ EA V Q W TY FGYLA A VKS QNG AAM SF G R V S TF L DV Y IE RD LKA G KLN E QE A Q E LI D HLVMK 312
Cdd:cd00576 41 ------------ VNET A KSIN EA I Q K TY QIIAL A ASN QNG GGV SF A R A S SI L SP Y GS RD YAK G SGT E TD A V E AA D AFNLA 108
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 313 L RM V RFL rtpeydelf S G DPIW AT ESV GG MGVD grt LVT K N S FR FLN TLYTM G ---- P SPE PN ITILW S EKL P L ------ 382
Cdd:cd00576 109 L KE V GQG --------- N G RTGA AT GFI GG VHKG --- KGD K I S QE FLN LALAN G gegi P LNF PN LSVRV S SDK P G ilvkav 176
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 383 NF K KFA A KVSID T S S LQYE ND dlmrpdfnnddya IA C cvspmvvgkqmqf FGARA NLA KT M LY AING gvdeklkmqvgpk 462
Cdd:cd00576 177 EL K QLI A EEARK T G S PGIF ND ------------- EL C ------------- NLVSL NLA RI M EK AING ------------- 217
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 463 sapikgdllnfde V M ERMDHFMDW LA KQY V T AL NIIHYM HD KYSYE aslm ALHDR D VI RT MAC GIAG LSVAADS L SAI K Y 542
Cdd:cd00576 218 ------------- S M DVVLEELEE LA FLA V R AL DCVIDS HD ERIPT ---- IELGG D ER RT VGL GIAG VADLLIK L GLE K V 280
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 543 A kvkpirdedglaidfeiegeypqfgnn D ARV DDLA VD LV ERFM K KIQQLKTY R NAIPTQSVLTIT SN vvygkktgntpd 622
Cdd:cd00576 281 G --------------------------- D PEA DDLA AE LV DQLK K HLVKATNE R GFNFLLGLSPSE SN ------------ 321
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 623 gr RA GAP FGP G AN P MH G R ------ DQK G AVA SL T SVA K L P F a YA KD GIS Y T FS I VPN A LGK D devrkt N L AGLM DG YFHH 696
Cdd:cd00576 322 -- SS GAP ATN G VS P SR G * iaivln GDI G PEE SL A SVA I L Q F - YA DN GIS D T IT I PDS A TNL D ------ Q L LAVI DG AAAI 392
570
....*....|....
gi 506220934 697 easie GGQ H LN VN V 710
Cdd:cd00576 393 ----- KTT H VR VN P 401
PFL2_DhaB_BssA
cd01677 Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 ...
95-755
7.65e-84
Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 (PFL2), B12-independent glycerol dehydratase (DhaB) and the alpha subunit of benzylsuccinate synthase (BssA), all of which have a highly conserved ten-stranded alpha/beta barrel domain, which is similar to those of PFL1 (pyruvate formate lyase 1) and RNR (ribonucleotide reductase). Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. DhaB catalyzes the first step in the conversion of glycerol to 1,3-propanediol while BssA catalyzes the first step in the anaerobic mineralization of both toluene and m-xylene.
Pssm-ID: 153086 [Multi-domain]
Cd Length: 781
Bit Score: 282.63
E-value: 7.65e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 95 E K IVG LQTEA P lk RA IIP F ggikm V E G S CKA -------- YN R EL DP --------- Q L KK IF t E Y -- R KT HNQGV F DVYTK 155
Cdd:cd01677 61 E L IVG NRGGK P -- RA VPV F ----- P E L S VHW vedelddl PK R PG DP fvisedkke Y L EE IF - P Y wk G KT LRDRC F KYFPE 132
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 156 DI L NCRKS GV L T GLPDAY - G R G RIIG DY RR V ALY G I D F LI KDKYAQFVS L QS - DL E NG --- VNLE A T I RLR E EI --- A EQ 227
Cdd:cd01677 133 ET L IAMAA GV F T EFMYFF s G P G HVAV DY PK V LEK G L D G LI EEAKEAIEA L DL t GP E DI dki YFYQ A M I IVC E AV ity A KR 212
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 228 HRA L G qi KE M AAK YG -------- CD I SG -------- P ATNAQ EA V Q WTY F GY L AAVKSQ NG AAM S F GR VSTF L DVYIER D 291
Cdd:cd01677 213 YAE L A -- KE L AAK ET dpkrkael LE I AE icrrvpah P PRTFW EA L Q SFW F IH L ILQIES NG HSI S P GR FDQY L YPFYKQ D 290
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 292 LKA G K L NEQE A Q EL IDH L VM K LRMVRFL R TPEYDEL F S G DPIWATESV GG MGV DG RTLVTKN S FRF L NTLYTM g PS P E P N 371
Cdd:cd01677 291 IEE G R L TREG A I EL LEC L WI K INEINKV R SGASAKY F A G YNTFQNLTI GG QTE DG SDATNEL S YLI L EATRRV - RL P Q P S 369
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 372 I T ILWSE K L P LN F K K F AA K V SIDTSSL - QYE ND DLMR P DFNND -------- DY AIAC CV SPMVV G KQMQFF G ARA - NLAK 441
Cdd:cd01677 370 L T VRYHA K S P DK F L K K AA E V IRLGLGY p AFF ND EVVI P ALLRK gvsledar DY GLIG CV ETGAP G RKYRWT G TGY i NLAK 449
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 442 TMLYAI N G G V D EKLKM QVGP KSAPIK g D LLN F D E VM E RMDHFMDWLA K QY V T A L NI IHYM H DKYSYEAS L M AL H D ----- 516
Cdd:cd01677 450 VLEITL N N G K D PRSGK QVGP ETGDAT - D FKT F E E LW E AFKKQLRHFI K LS V R A N NI SDIA H AEVAPAPF L S AL V D dciek 528
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 517 - R D V --------- IRTMAC GIA gls VAA DSL S AIK Y ----- A K VKPIRDEDG L AID F E i EG E --------- Y P QF GN N D A 572
Cdd:cd01677 529 g K D I naggarynf GGIQGV GIA --- TLG DSL A AIK K lvfee K K LTMEELLEA L KAN F A - EG Y eerrrllnn A P KY GN D D D 604
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 573 RV D DL A VDLV E RFM K KIQQLKTY R NAIPTQSVLTITS NV VY G KK TG N TPDGR R AG A P FGP G AN P MH G R D Q KG AV A SLT SV 652
Cdd:cd01677 605 YA D NI A RRVY E WYC K EVEKYQNP R GGKFYPGTYSVSA NV PF G SV TG A TPDGR L AG T P LSD G VS P SQ G T D K KG PT A VIK SV 684
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 653 A KL PFAYAKD G ISYTFSIV P NA L GKDDEVR K tn LA G L MDG YF hheas IE GG Q H LNV NV MNR E M L L DA ME HPEKY PQ L TI R 732
Cdd:cd01677 685 S KL DHFNISG G TLLNQKFS P ST L EGEEGLK K -- LA A L IRT YF ----- DL GG H H IQF NV VSA E T L R DA QK HPEKY RD L IV R 757
730 740
....*....|....*....|...
gi 506220934 733 V S GY AVR F NS L T KE Q Q QDV I T RT 755
Cdd:cd01677 758 V A GY SAY F VE L S KE V Q DEI I A RT 780
Gly_radical
pfam01228 Glycine radical;
630-741
6.08e-51
Glycine radical;
Pssm-ID: 426140 [Multi-domain]
Cd Length: 106
Bit Score: 173.12
E-value: 6.08e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 630 FG PG AN P M HG R D QK G AV A S L T SV A K LPFAYAK DGIS YTFSIV P NA LG KD DE VRKT NL AG L M D G YF H heasie GG Q HL NV N 709
Cdd:pfam01228 1 VA PG IS P S HG A D FE G PT A V L N SV G K IDYEVEL DGIS LNQKFL P AV LG YY DE EGYA NL NT L I D T YF E ------ GG H HL QF N 74
90 100 110
....*....|....*....|....*....|..
gi 506220934 710 V MN RE M L L DA ME HPEKYP Q LT I RVSGY AVR F N 741
Cdd:pfam01228 75 V VD RE T L P DA QK HPEKYP D LT V RVSGY SAN F V 106
pflD
PRK09983 putative formate acetyltransferase 2; Provisional
174-758
5.70e-45
putative formate acetyltransferase 2; Provisional
Pssm-ID: 182181 [Multi-domain]
Cd Length: 765
Bit Score: 173.08
E-value: 5.70e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 174 G R G R II G DY R R VALY G IDF L I k DKYA Q FVSL Q SDLE ---- NGVN LEA TIR ------- L R E EI A E ----- Q H R A lg QIKEM 237
Cdd:PRK09983 153 G Q G H II I DY P R LLNH G LGE L V - AQMQ Q HCQQ Q PENH fyqa ALLL LEA SQK hilryae L A E TM A A nctda Q R R E -- ELLTI 229
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 238 A AKYGCDISGPATNAQE A V Q WTYFGYLAAVKSQ N GAAM S F GR VSTFLDVYIERD L KA G K l NEQEAQ EL IDH L VM K LRMVR 317
Cdd:PRK09983 230 A EISRHNAQHKPQTFWQ A C Q LFWYMNIILQYES N ASSL S L GR FDQYMLPFYQAS L TQ G E - DPAFLK EL LES L WV K CNDIV 308
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 318 F LR TPEYDEL F S G D P IWA T ESV GG MGVD GR TL V TKN SF RF L NT l Y TMGPS P E PN ITILWSEKLPLN F - K K F A AKVSID T S 396
Cdd:PRK09983 309 L LR STSSARY F A G F P TGY T ALL GG LTEN GR SA V NVL SF LC L DA - Y QSVQL P Q PN LGVRTNALIDTP F l M K T A ETIRLG T G 387
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 397 SL Q YE ND DLMR P D F N N D -------- DY AIAC CV SPMVV G KQ mqf F G ---- A RA NL A K T M lyainggvd E KLKMQVGPKS A 464
Cdd:PRK09983 388 IP Q IF ND EVVV P A F L N R gvsledar DY SVVG CV ELSIP G RT --- Y G lhdi A MF NL L K V M --------- E ICLHENEGNA A 455
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 465 PIKGD LL nf DEVMERMD H FM dwla KQY V TAL NI IHYM H DKYSYEAS L MAL ------ HD RD VI ---- R TMAC G IA G LSV A - 533
Cdd:PRK09983 456 LTYEG LL -- EQIRAKIS H YI ---- TLM V EGS NI CDIG H RDWAPVPL L SSF isdcle KG RD IT dgga R YNFS G VQ G IGI A n 529
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 534 - A DSL S A I K yakv KPIR D EDG L AI D FEI ---------- EGE --------- YPQF GN NDAR VD DLAVD L VERFM K KIQQLK 593
Cdd:PRK09983 530 l S DSL H A L K ---- GMVF D QQR L SF D ELL svlkanfatp EGE kvrarlinr FEKY GN DIDE VD NISAE L LRHYC K EVEKYQ 605
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 594 TY R NAIP T QSVL T ITSN V VY G KKT G N TPDGR R AG APFGP G A - N PM H G R D QK G AV A S L T SV A KL PFAYAKD G ISYTFSIV P 672
Cdd:PRK09983 606 NP R GGYF T PGSY T VSAH V PL G SVV G A TPDGR F AG EQLAD G G l S PM L G Q D AQ G PT A V L K SV S KL DNTLLSN G TLLNVKFT P 685
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 673 NA L GKDDEV RK tn LA GLMDGYFHHEA siegg QH LNV NV M N REM L LD A MEH P EK Y PQ L TI RV S GY AVR F NS L T KE Q Q Q D V I 752
Cdd:PRK09983 686 AT L EGEAGL RK -- LA DFLRAFTQLKL ----- QH IQF NV V N ADT L RE A QQR P QD Y AG L VV RV A GY SAF F VE L S KE I Q D D I I 758
....*.
gi 506220934 753 T RT FT Q 758
Cdd:PRK09983 759 R RT AH Q 764
PRK11127
PRK11127 autonomous glycyl radical cofactor GrcA; Provisional
697-760
2.30e-40
autonomous glycyl radical cofactor GrcA; Provisional
Pssm-ID: 182983 [Multi-domain]
Cd Length: 127
Bit Score: 144.22
E-value: 2.30e-40
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 506220934 697 E ASI EGGQHLNVNV MN RE M L L DA ME HPEKYPQLTIRVSGYAVRFNSLT K EQQ Q DVI T RTFT QTM 760
Cdd:PRK11127 64 E VRV EGGQHLNVNV LR RE T L E DA VK HPEKYPQLTIRVSGYAVRFNSLT P EQQ R DVI A RTFT ESL 127
GrcA
COG3445 Autonomous glycyl radical cofactor GrcA [Coenzyme transport and metabolism];
696-760
1.62e-39
Autonomous glycyl radical cofactor GrcA [Coenzyme transport and metabolism];
Pssm-ID: 442669 [Multi-domain]
Cd Length: 125
Bit Score: 141.80
E-value: 1.62e-39
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 506220934 696 HEASI EGGQHLNVNV MN RE M L L DA ME HPEKYPQLTIRVSGYAVRFNSLT K EQQ Q DVITRTFT QTM 760
Cdd:COG3445 61 APPRV EGGQHLNVNV LR RE T L E DA VK HPEKYPQLTIRVSGYAVRFNSLT P EQQ R DVITRTFT ESL 125
spare_glycyl
TIGR04365 autonomous glycyl radical cofactor GrcA; This small protein, previously designated YfiD in E. ...
696-760
2.17e-38
autonomous glycyl radical cofactor GrcA; This small protein, previously designated YfiD in E. coli, is closely homologous to pyruvate formate_lyase (PFL) in a region surrounding the stable glycyl radical that is prepared by the action of pyruvate formate-lyase activase, a radical SAM enzyme. When damage at the site of this radical breaks the main chain of PFL, this protein acts as a spare part that reintroduces the needed stable glycyl radical. Cutoffs for this model are set to exclude a set of closely related phage proteins that appear to have a corresponding function.
Pssm-ID: 213978 [Multi-domain]
Cd Length: 124
Bit Score: 138.78
E-value: 2.17e-38
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 506220934 696 HE A SI EGGQHLNVNV MN RE M L L DA MEH PEKYPQLTIRVSGYAVRFNSLT K EQQ Q DVITRTFT QTM 760
Cdd:TIGR04365 60 AP A KV EGGQHLNVNV LT RE T L E DA VKN PEKYPQLTIRVSGYAVRFNSLT P EQQ R DVITRTFT ESL 124
choline_CutC
TIGR04394 choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and ...
221-755
3.93e-37
choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme. [Energy metabolism, Amino acids and amines]
Pssm-ID: 275187 [Multi-domain]
Cd Length: 789
Bit Score: 149.18
E-value: 3.93e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 221 R E EIAEQHRA L GQ I K E MA A KYG cdi SGPATNAQ EA V Q -- WT YFGY L AAVKS Q N G aa MS F GRV STFLDVYIER D LK AG KLN 298
Cdd:TIGR04394 228 K E QDPKRKAE L EK I A E VN A RVP --- AHKPRTFW EA I Q sv WT VESL L VVEEN Q T G -- MS I GRV DQYMYPFYKA D IE AG RMT 302
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 299 E Q EA Q EL IDHLVM K LRMVRF L RTPEYDEL F S G DPIWATES VGG MGVD G R ------ T LVTKNSF R FLN t L Y tmgpsp E P NI 372
Cdd:TIGR04394 303 E Y EA F EL AGCMLI K MSEMMW L TSEGGSKF F A G YQPFVNMC VGG VTRE G G datndl T YLLMDAV R HVK - V Y ------ Q P SL 375
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 373 TILWSE K L P lnf K K FAA K - V SIDTSSLQYEN --- DD ----- LMRPDFNND D --- Y AIAC CV S P MVV G KQM Q FFG - A RANL 439
Cdd:TIGR04394 376 ACRIHN K S P --- Q K YLK K i V DVVRAGMGFPA chf DD ahikm MLAKGVSIE D ard Y CLMG CV E P QKS G RLY Q WTS t A YTQW 452
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 440 AKTMLYAI N G GV DEKLKM QV G P KS apik GDL LN FD E ------- V M E RMDHFMD W L A KQY V TALNIIHYMHD K ysyea S LM 512
Cdd:TIGR04394 453 PICIELVL N H GV PLWYGK QV C P DT ---- GDL SQ FD T yekfdaa V K E QIKYITK W S A VAT V ISQRVHRDLAP K ----- P LM 523
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 513 A L ------- HDR DV IRTM A C ----- G I -- A GL SVA ADS LS AIK --- Y AKV K PIRDEDGL A IDFEI EG --------- EY P Q 566
Cdd:TIGR04394 524 S L myegcme KGK DV SAGG A M ynfgp G V vw S GL ATY ADS MA AIK klv Y DDK K YTLEQLNE A LKANF EG yeqiradcl DA P K 603
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 567 F GN N D ARV D DL A V DLV ERFMKKIQQL KT YRNAI p TQSV L T I TS N VVY G KK TG NTPD GR R A GA P FGP G AN P MH G R D Q KG AV 646
Cdd:TIGR04394 604 Y GN D D DYA D LI A A DLV NFTEREHRKY KT LYSHL - SHGT L S I SN N TPF G QL TG ASAN GR L A WT P LSD G IS P TQ G A D F KG PT 682
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506220934 647 A SLT SV A K LPFAYAKD G ISYT F SIVPNA L gk D DEVRKTN L AG L M dgyfh HE ASI E G GQHLNV N VMNR E M LLDA ME HPEKY 726
Cdd:TIGR04394 683 A IIK SV S K MANDSMNI G MVHN F KLMSGL L -- D TPEGENG L IT L L ----- RT ASI L G NGEMQF N YLDN E T LLDA QQ HPEKY 755
570 580
....*....|....*....|....*....
gi 506220934 727 PQ L TI RV S GY AVR F NS L T K EQ Q QDV I T RT 755
Cdd:TIGR04394 756 RD L VV RV A GY SAF F VE L C K DV Q DEI I S RT 784
rad_fix_GrcA3
NF038360 autonomous glycyl radical cofactor GrcA3; This small protein, like GrcA and GrcA2, is a ...
685-760
1.53e-34
autonomous glycyl radical cofactor GrcA3; This small protein, like GrcA and GrcA2, is a lineage-specific small protein related to the glycyl radical active site-containing C-terminal region of pyruvate formate-lyase (PFL, also called formate C-acetyltransferase) from similar species. Because PFL is prone to damage and inactivation, this protein is made as a spare part that fills in for the portion of the protein that was damaged and lost. The distinct families we now call GrcA, GrcA2, and GrcA3 all have the surprising property of being much more closely related to some full length PFL than to members of the other GrcA-series families.
Pssm-ID: 439653 [Multi-domain]
Cd Length: 78
Bit Score: 126.01
E-value: 1.53e-34
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506220934 685 NL AG L M DGY fhhea SIE GG Q HLNVNV M NRE M LLDA ME HPEKYPQLT I RVSGYAV R FN S LTKEQQ QD VI T RTF TQT M 760
Cdd:NF038360 8 NL VS L L DGY ----- AEK GG H HLNVNV F NRE T LLDA QA HPEKYPQLT V RVSGYAV N FN K LTKEQQ DE VI S RTF HEA M 78
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
