Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505806503   93 GRFTRAYLRYLSNpeltDTHESRQLMVLSLAMPDEPVLRKCWRDWMLDHLAQ--GDALDnGPTGTLVRYAADGIWLSELT 170
Cdd:pfam17937   1 GRWLRAYLRATFD----DAAERRLLAALLAALAEDPELLEPWREWYRRWLERleADGLD-PVLATIVRLAADGLWLAELL 75

                          90       100
                  ....*....|....*....|.
gi 505806503  171 EGRTMSSEHRQALVNDLTKMT 191
Cdd:pfam17937  76 GLPPLDPEEREALLDRLLALT 96

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505806503   93 GRFTRAYLRYLSNpeltDTHESRQLMVLSLAMPDEPVLRKCWRDWMLDHLAQ--GDALDnGPTGTLVRYAADGIWLSELT 170
Cdd:pfam17937   1 GRWLRAYLRATFD----DAAERRLLAALLAALAEDPELLEPWREWYRRWLERleADGLD-PVLATIVRLAADGLWLAELL 75

                          90       100
                  ....*....|....*....|.
gi 505806503  171 EGRTMSSEHRQALVNDLTKMT 191
Cdd:pfam17937  76 GLPPLDPEEREALLDRLLALT 96

Bacterial regulatory proteins, tetR family;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 505806503   23 LLESAAMIAGRDGIAALSLNAVAREAGVSKGGLMHHFPNKQALIFAL 69
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47

HTH-type transcriptional regulator RutR; Provisional

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505806503  12 RKKDPVRLHRQLLESAAMIA-GRDGIAALSLNAVAREAGVSKGGLMHHFPNKQALIFALFARLLAI 76
Cdd:PRK15008  11 KRSRAVSAKKKAILSAALDTfSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDI 76

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505806503   93 GRFTRAYLRYLSNpeltDTHESRQLMVLSLAMPDEPVLRKCWRDWMLDHLAQ--GDALDnGPTGTLVRYAADGIWLSELT 170
Cdd:pfam17937   1 GRWLRAYLRATFD----DAAERRLLAALLAALAEDPELLEPWREWYRRWLERleADGLD-PVLATIVRLAADGLWLAELL 75

                          90       100
                  ....*....|....*....|.
gi 505806503  171 EGRTMSSEHRQALVNDLTKMT 191
Cdd:pfam17937  76 GLPPLDPEEREALLDRLLALT 96

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505806503  21 RQLLESAAMIAGRDGIAALSLNAVAREAGVSKGGLMHHFPNKQALIFALFARLLAIMEKAISELMAADNI--AYGRFTRA 98
Cdd:COG1309    9 ERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPreRLRALLRA 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505806503  99 YLRYLSNPEltdtHESRQLMVLSLAMPDEPVLRKCWRDWMLDHLAQGDALDNGPTGTLVRYAADGIW 165
Cdd:COG1309   89 YLEFLAENP----ALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALL 151

ScbR family autoregulator-binding transcription factor;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505806503  17 VRLHRQLLESAAMIAGRDGIAALSLNAVAREAGVSKGGLMHHFPNKQALIFALFARLLAIMEKAISELMAADniaygrft 96
Cdd:NF041196   5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGG-------- 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 505806503  97 RAYLRylsnpELTDThesrqLMVLSLAMPDEPVLR 131
Cdd:NF041196  77 GSKLQ-----ELVDL-----THVLARRLRTDPVVR 101

DNA-binding transcriptional regulator EnvR; Provisional

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 505806503   9 AQHRKKDPVRLHRQLLESA-AMIAGRdGIAALSLNAVAREAGVSKGGLMHHFPNKQAL 65
Cdd:PRK09975   2 AKKTKAEALKTRQELIETAiAQFALR-GVSNTTLNDIADAANVTRGAIYWHFENKTQL 58

transcriptional regulator BetI; Validated

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 505806503  16 PVRlhRQLLESAAMIA-GRDGIAALSLNAVAREAGVSKGGLMHHFPNKQALIFA 68
Cdd:PRK00767   8 PIR--RQQLIDATLRAiGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEA 59