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Conserved domains on  [gi|505582926|ref|WP_015675614|]
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AraC family transcriptional regulator [Salmonella enterica]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12071874)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 27-179 2.83e-50

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


:

Pssm-ID: 461994  Cd Length: 152  Bit Score: 163.06  E-value: 2.83e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926   27 RLAGIRLLYGVEPGPRTPVMYQPGIIFLFSGHKIGYINKRKFRYDANEYLLLTVPLPFECETW-AKPEVPLAGIRLDIDV 105
Cdd:pfam06719   1 AIPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEVTeASPEEPYLGLALDLDP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505582926  106 LQLQELLMDIGEDErfQLPMAASGINSATLSDEILCAVERLLDVMERPLDARILGKQIIREILYHVLMGPRGGA 179
Cdd:pfam06719  81 ALLAELLLEAPPPG--PPPRAGRGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLTGPQGAR 152
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
207-288 8.74e-28

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 103.02  E-value: 8.74e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926   207 NLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTP 286
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 505582926   287 GE 288
Cdd:smart00342  81 SE 82
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 27-179 2.83e-50

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 163.06  E-value: 2.83e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926   27 RLAGIRLLYGVEPGPRTPVMYQPGIIFLFSGHKIGYINKRKFRYDANEYLLLTVPLPFECETW-AKPEVPLAGIRLDIDV 105
Cdd:pfam06719   1 AIPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEVTeASPEEPYLGLALDLDP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505582926  106 LQLQELLMDIGEDErfQLPMAASGINSATLSDEILCAVERLLDVMERPLDARILGKQIIREILYHVLMGPRGGA 179
Cdd:pfam06719  81 ALLAELLLEAPPPG--PPPRAGRGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLTGPQGAR 152
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
207-288 8.74e-28

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 103.02  E-value: 8.74e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926   207 NLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTP 286
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 505582926   287 GE 288
Cdd:smart00342  81 SE 82
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
137-294 4.01e-26

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 103.71  E-value: 4.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 137 DEILCAVERLLDVMERPLDARILGKQIIREILYHVLMGPRGGALLALVSRQTHFSLISRVLKQIEMKYTENLNVEQLAAE 216
Cdd:COG2207   98 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARE 177

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505582926 217 ANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGEDAARMR 294
Cdd:COG2207  178 LGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLR 255
HTH_18 pfam12833
Helix-turn-helix domain;
213-288 6.70e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 87.26  E-value: 6.70e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505582926  213 LAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHD-GMKASAAAMRVGYESASQFSREFKRYFGVTPGE 288
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSE 77
ftrA PRK09393
transcriptional activator FtrA; Provisional
 193-287 1.08e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 61.52  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 193 ISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESAS 272
Cdd:PRK09393 220 LGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEE 299

                         90
                 ....*....|....*
gi 505582926 273 QFSREFKRYFGVTPG 287
Cdd:PRK09393 300 SLRHHFRRRAATSPA 314
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 27-179 2.83e-50

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 163.06  E-value: 2.83e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926   27 RLAGIRLLYGVEPGPRTPVMYQPGIIFLFSGHKIGYINKRKFRYDANEYLLLTVPLPFECETW-AKPEVPLAGIRLDIDV 105
Cdd:pfam06719   1 AIPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEVTeASPEEPYLGLALDLDP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505582926  106 LQLQELLMDIGEDErfQLPMAASGINSATLSDEILCAVERLLDVMERPLDARILGKQIIREILYHVLMGPRGGA 179
Cdd:pfam06719  81 ALLAELLLEAPPPG--PPPRAGRGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLTGPQGAR 152
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
207-288 8.74e-28

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 103.02  E-value: 8.74e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926   207 NLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTP 286
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 505582926   287 GE 288
Cdd:smart00342  81 SE 82
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
137-294 4.01e-26

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 103.71  E-value: 4.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 137 DEILCAVERLLDVMERPLDARILGKQIIREILYHVLMGPRGGALLALVSRQTHFSLISRVLKQIEMKYTENLNVEQLAAE 216
Cdd:COG2207   98 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARE 177

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505582926 217 ANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGEDAARMR 294
Cdd:COG2207  178 LGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLR 255
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 156-299 3.89e-23

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 96.77  E-value: 3.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 156 ARILGKQIIREILYHVLMGPR--GGA---LLALVSRQTHFSLISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKA 230
Cdd:COG4977  170 ERDHGAELANAVARRLVVDPRrpGGQaqfSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRA 249

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505582926 231 VTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGEDAARMRTMQGS 299
Cdd:COG4977  250 ATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARAAA 318
HTH_18 pfam12833
Helix-turn-helix domain;
213-288 6.70e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 87.26  E-value: 6.70e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505582926  213 LAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHD-GMKASAAAMRVGYESASQFSREFKRYFGVTPGE 288
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSE 77
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 192-288 1.54e-19

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 87.42  E-value: 1.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 192 LISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARmMMIHDGMKASAAAMRVGYESA 271
Cdd:COG2169   85 LVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRAR-QLLQTGLSVTDAAYAAGFGSL 163

                         90
                 ....*....|....*..
gi 505582926 272 SQFSREFKRYFGVTPGE 288
Cdd:COG2169  164 SRFYEAFKKLLGMTPSA 180
ftrA PRK09393
transcriptional activator FtrA; Provisional
 193-287 1.08e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 61.52  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 193 ISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESAS 272
Cdd:PRK09393 220 LGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEE 299

                         90
                 ....*....|....*
gi 505582926 273 QFSREFKRYFGVTPG 287
Cdd:PRK09393 300 SLRHHFRRRAATSPA 314
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
130-288 6.05e-08

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 52.76  E-value: 6.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 130 INSATLSDeilcaVERLLDVMERPLDARILGKQIIREILY-HVLMGPRGGALLALVSRQThfSLISRVLKQIEMKYTENL 208
Cdd:PRK13503 116 VNQSVLQQ-----VRQLVAQMEQQEESNDLEAIASREILFmQLLVLLRKSSLQENGENSD--ARLNQLLAWLEDHFAEEV 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 209 NVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGE 288
Cdd:PRK13503 189 NWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRD 268
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 179-294 7.79e-08

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 52.73  E-value: 7.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 179 ALL--ALVSRQT----HFSLISRVLKQIEMKYT-ENLNVEQLAAEANMSVSAFHHNFkAVTSTSPLQYLKSYRLHKARMM 251
Cdd:PRK09685 179 ALLrpALHQRESvqprRERQFQKVVALIDQSIQeEILRPEWIAGELGISVRSLYRLF-AEQGLVVAQYIRNRRLDRCADD 257

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 505582926 252 MIHDGMKASAA--AMRVGYESASQFSREFKRYFGVTPGEDAARMR 294
Cdd:PRK09685 258 LRPAADDEKITsiAYKWGFSDSSHFSTAFKQRFGVSPGEYRRKFR 302
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 200-241 6.89e-07

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 45.22  E-value: 6.89e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 505582926  200 IEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLK 241
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
205-288 2.73e-06

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 48.05  E-value: 2.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 205 TENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGV 284
Cdd:PRK10572 197 ASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGA 276


                 ....
gi 505582926 285 TPGE 288
Cdd:PRK10572 277 SPSE 280
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
188-286 6.55e-06

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 44.15  E-value: 6.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 188 THFSLISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVG 267
Cdd:PRK10219   2 SHQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLG 81

                         90
                 ....*....|....*....
gi 505582926 268 YESASQFSREFKRYFGVTP 286
Cdd:PRK10219  82 YVSQQTFSRVFRRQFDRTP 100
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
208-286 6.74e-06

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 47.10  E-value: 6.74e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505582926 208 LNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHdGMKASAAAMRVGYESASQFSREFKRYFGVTP 286
Cdd:PRK15435 100 VTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAK-GESVTTSILNAGFPDSSSYYRKADETLGMTA 177
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 179-298 1.90e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 45.30  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 179 ALLALVSRQTHF----------SLISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAvTSTSPLQYLKSYRLHKA 248
Cdd:PRK09978 120 ALLSVFLEDEHFiplllnvlqpNMRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLRE-EETSYSQLLTECRMQRA 198

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505582926 249 RMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGE------------DAARMRTMQG 298
Cdd:PRK09978 199 LQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEyqersaqglpnrDSAASIVAQG 260
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
186-286 2.04e-05

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 43.17  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 186 RQTHFSLISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMR 265
Cdd:PRK11511   4 RNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAER 83

                         90       100
                 ....*....|....*....|.
gi 505582926 266 VGYESASQFSREFKRYFGVTP 286
Cdd:PRK11511  84 YGFESQQTLTRTFKNYFDVPP 104
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
188-288 3.01e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 44.66  E-value: 3.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 188 THFSLISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVG 267
Cdd:PRK13502 173 SRETLLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCG 252

                         90       100
                 ....*....|....*....|.
gi 505582926 268 YESASQFSREFKRYFGVTPGE 288
Cdd:PRK13502 253 FEDSNYFSVVFTRETGMTPSQ 273
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
178-288 1.08e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 43.17  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 178 GALLALVSRQTHFS----------LISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHK 247
Cdd:PRK13500 183 GQLVMLLNRHRYTSdslpptssetLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCH 262

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 505582926 248 ARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGE 288
Cdd:PRK13500 263 AQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQ 303
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
184-294 3.35e-04

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 41.83  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 184 VSRQTHFSLISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASA-- 261
Cdd:PRK10130 233 ISHQSYRRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQSTTvk 312

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 505582926 262 -AAMRVGYESASQFSREFKRYFGVTPGED-AARMR 294
Cdd:PRK10130 313 dAAMQWGFWHLGQFATDYQQLFAEKPSLTlHQRMR 347
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 253-288 4.00e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 37.52  E-value: 4.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 505582926  253 IHDGMKASAAAMRVGYeSASQFSREFKRYFGVTPGE 288
Cdd:pfam00165   5 LSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQ 39
PRK10371 PRK10371
transcriptional regulator MelR;
184-286 6.11e-04

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 40.96  E-value: 6.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 184 VSRQTHFsLISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAA 263
Cdd:PRK10371 185 VSRHAQF-YVSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIA 263

                         90       100
                 ....*....|....*....|...
gi 505582926 264 MRVGYESASQFSREFKRYFGVTP 286
Cdd:PRK10371 264 LTAGFRSSSRFYSTFGKYVGMSP 286
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 163-288 8.05e-04

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 40.43  E-value: 8.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 163 IIREILYHVLMGPRGGALLALVSRQTHFSLISRVL-KQIEMKYTenlnVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLK 241
Cdd:PRK15186 156 LIRFLLSEFIYEPEAFALFRELSQNTLAENIYNIIiSDISRKWA----LKDISDSLYMSCSTLKRKLKQENTSFSEVYLN 231

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 505582926 242 SyRLHKARMMMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGE 288
Cdd:PRK15186 232 A-RMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSE 277
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
192-297 1.13e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 39.89  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 192 LISRVLKQIemkyTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLKSYRLHKARMMMIHDGMKASAAAMRVGYESA 271
Cdd:PRK13501 181 IMSALQQSL----GAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDS 256

                         90       100
                 ....*....|....*....|....*.
gi 505582926 272 SQFSREFKRYFGVTPgeDAARMRTMQ 297
Cdd:PRK13501 257 NYFSAVFTREAGMTP--RDYRQRFIR 280
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 183-286 3.17e-03

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 38.44  E-value: 3.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582926 183 LVSRQTHFSLISRVLKQIEMKYTENLNVEQLAAEANMSVSAFHHNFKAVTSTSPLQYLkSYRLHKARMMMIHDGMKASAA 262
Cdd:PRK15185 198 IILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYL-SARMNQAAKLLRIGNHNVNAV 276

                         90       100
                 ....*....|....*....|....
gi 505582926 263 AMRVGYESASQFSREFKRYFGVTP 286
Cdd:PRK15185 277 ALKCGYDSTSYFIQCFKKYFKTTP 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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