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Conserved domains on  [gi|505403041|ref|WP_015590143|]
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DUF2341 domain-containing protein [Archaeoglobus sulfaticallidus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MJ1470 super family cl34978
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 352-460 4.84e-40

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


The actual alignment was detected with superfamily member COG5306:

Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 156.99  E-value: 4.84e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  352 PGWDYRKAITI-TNQNSFSLTDYQIKIELNSSNFDFTKANSDGSDIRFTESDGSTFLNYWIESWDPSNQTATIWVKV-NI 429
Cdd:COG5306    26 PDWSYRKPITIdTTAIGGDLTDYPVLVRLHTGNFDFSSAKEDGSDIRFVAGDDKTPLKYWIEKFDPLNEMALVWVKVpSI 105

                          90       100       110
                  ....*....|....*....|....*....|.
gi 505403041  430 PASTSKTIYMYYGNSSATSMSNGDSTFVFFD 460
Cdd:COG5306   106 PAGAGTTIWLYYGNPKAPSASDGKGTFDFFD 136
MJ1470 super family cl34978
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 757-860 5.66e-36

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


The actual alignment was detected with superfamily member COG5306:

Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 144.66  E-value: 5.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  757 PGWDYRKAITI-TNQNSFSLTDYQIKIELNSSNFDFTKANSDGSDIRFTESDGSTFLNYWIESWDPSNQTATIWVKV-NI 834
Cdd:COG5306    26 PDWSYRKPITIdTTAIGGDLTDYPVLVRLHTGNFDFSSAKEDGSDIRFVAGDDKTPLKYWIEKFDPLNEMALVWVKVpSI 105

                          90       100
                  ....*....|....*....|....*.
gi 505403041  835 PASTSKTIYMYYGNSSATSMSNPEKT 860
Cdd:COG5306   106 PAGAGTTIWLYYGNPKAPSASDGKGT 131
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 259-344 2.12e-22

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


:

Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 92.72  E-value: 2.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   259 NNPPVAAFTyTPATPLVGDIITFNASSSYDPDGDkITDYIWDFGDGDTATGVVTTHSYSSPGTYDVTLTVYDERGGVNST 338
Cdd:pfam18911    1 NAAPVADAG-GDRIVAEGETVTFDASASDDPDGD-ILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNST 78


                   ....*..
gi 505403041   339 -TVAIEV 344
Cdd:pfam18911   79 aTDTVTV 85
CARDB pfam07705
CARDB; Cell adhesion related domain found in bacteria.
 151-250 2.84e-17

CARDB; Cell adhesion related domain found in bacteria.


:

Pssm-ID: 400172 [Multi-domain]  Cd Length: 101  Bit Score: 78.47  E-value: 2.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   151 DLTISLKVSNANPEVNEEITIYADVMNVGSEDiNESFTVRFYYDSIEIYNEIINGLTSQSVEHISFSYTPTSTGQHVIKG 230
Cdd:pfam07705    3 DLIVQSISPPSEAYVGEENTITVTVKNQGTAA-AGAFNVALYVDGTSVGTITVPGLAAGESTTVSFSWTPPTEGSYTLTV 81

                           90       100
                   ....*....|....*....|
gi 505403041   231 VVDADGAIVEDNENNNVSSK 250
Cdd:pfam07705   82 VVDPDNTVAESNETNNELTK 101
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 670-738 2.43e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


:

Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 74.73  E-value: 2.43e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505403041   670 TPSTPQVNEEITFNASSSTpsepgGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGR 738
Cdd:pfam00801    4 SGTVVAAGQPVTFTATLAD-----GSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGS 67
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 1083-1151 2.43e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


:

Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 74.73  E-value: 2.43e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505403041  1083 TPSTPQVNEEITFNASSSTpsepgGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGR 1151
Cdd:pfam00801    4 SGTVVAAGQPVTFTATLAD-----GSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGS 67
COG3430 COG3430
Archaeal flagellin (archaellin), FlaG/FlaF family [Cell motility];
5-78 1.71e-11

Archaeal flagellin (archaellin), FlaG/FlaF family [Cell motility];


:

Pssm-ID: 442656  Cd Length: 91  Bit Score: 61.96  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041    5 MKFSGDDRAVSELISIILMIAITVgafsVIAVSIYSFL--------QTPPSKHADFQAEKIGDELVIYHTGGEELSGDDI 76
Cdd:COG3430     4 KKGMSDERAVSPVIGVILMVAITV----ILAAVIGVFVfglgddvsEPAPQASLSVEFVGDGDSVTITHEGGDPVNVDDL 79


                  ..
gi 505403041   77 II 78
Cdd:COG3430    80 KV 81
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
1080-1386 1.17e-08

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


:

Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 58.53  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1080 FTFTPSTPQVNEEITFNASSStpsepgGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRQDSVTKQV 1159
Cdd:COG3291     1 FTATPTSGCAPLTVQFTDTSS------GNATSYEWDFGDGTT--STEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1160 EVSETLFDPGFAYEDVNGNLMYDPGVDVQILASEIQDGVYDAGSNGLVIPPSVGDITASSIYFKGRDVVVSVDLTASKGV 1239
Cdd:COG3291    73 TVGAPNPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1240 EIIGSDSVDITGVSVSSTNYNRDVVIQAGKILANGTDITAHGEVFLKATNIYISDSTIDTSSEYNMKISIDATNYVFANN 1319
Cdd:COG3291   153 ATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTD 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505403041 1320 ATLKSQAKIDLGGNSLSGDGMSIDNSKAYDMKVNIVFLEDISLNNANIVSQGVVTINAGTQLTASDI 1386
Cdd:COG3291   233 VTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNV 299
PHA01755 super family cl39126
hypothetical protein
 359-635 6.68e-04

hypothetical protein


The actual alignment was detected with superfamily member PHA01755:

Pssm-ID: 222834  Cd Length: 562  Bit Score: 44.21  E-value: 6.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  359 AITITN-QNSFSLTDYQIKIELNSSNFdfTKANSDGSDIRF-TESDGSTFLNYWIESWDPSNQTATIWVK--VNIPASTS 434
Cdd:PHA01755  227 TITITNsQPDPTPSPFQQLLILNLSNI--ISSPSQLLNLQFcLDSQCSTPLYAWIESYNSNLSTVYIWINlpISIPANSS 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  435 KTIYMYYGNSSA---TSM-SNGDSTFVFFDD--------FEGTSLNTTKWATNTDTYQVEN--------GAIRLWGSWND 494
Cdd:PHA01755  305 ITIYMFVRNSIQypyTGMrPDLTSTYAQYDNgknvfliyFNGNEPLSNFNQEGNTIQQISTfgplgntiNAIYLSGYENN 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  495 GAYLNTRDSFSGSFVVegrwrlsTTSKDVDLAVVF----AEYSNSYMWESTSITCTYDSQST---SRPYYQKDLNVKGTh 567
Cdd:PHA01755  385 VGFVYTGKSETNQPVI-------SEASSQRMPNQTgglgAYNGTAGIADSTNTAFINDIGVTmgeDTSYFSQYYYVNGG- 456

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505403041  568 vdwgpeiESSDWQKFRIIFTQSYINYWdswsaensakpslEYSGSTFSTFYLGIAADSDSTSrYGYID 635
Cdd:PHA01755  457 -------ETGGSNYQGSAVSQWVYAWV-------------QYQGSSASSWFGCIAPQLYSSP-GGYCG 503
 
Name Accession Description Interval E-value
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 352-460 4.84e-40

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 156.99  E-value: 4.84e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  352 PGWDYRKAITI-TNQNSFSLTDYQIKIELNSSNFDFTKANSDGSDIRFTESDGSTFLNYWIESWDPSNQTATIWVKV-NI 429
Cdd:COG5306    26 PDWSYRKPITIdTTAIGGDLTDYPVLVRLHTGNFDFSSAKEDGSDIRFVAGDDKTPLKYWIEKFDPLNEMALVWVKVpSI 105

                          90       100       110
                  ....*....|....*....|....*....|.
gi 505403041  430 PASTSKTIYMYYGNSSATSMSNGDSTFVFFD 460
Cdd:COG5306   106 PAGAGTTIWLYYGNPKAPSASDGKGTFDFFD 136
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 757-860 5.66e-36

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 144.66  E-value: 5.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  757 PGWDYRKAITI-TNQNSFSLTDYQIKIELNSSNFDFTKANSDGSDIRFTESDGSTFLNYWIESWDPSNQTATIWVKV-NI 834
Cdd:COG5306    26 PDWSYRKPITIdTTAIGGDLTDYPVLVRLHTGNFDFSSAKEDGSDIRFVAGDDKTPLKYWIEKFDPLNEMALVWVKVpSI 105

                          90       100
                  ....*....|....*....|....*.
gi 505403041  835 PASTSKTIYMYYGNSSATSMSNPEKT 860
Cdd:COG5306   106 PAGAGTTIWLYYGNPKAPSASDGKGT 131
DUF2341 pfam10102
Domain of unknown function (DUF2341); Members of this family are found in various bacterial ...
 392-475 4.33e-33

Domain of unknown function (DUF2341); Members of this family are found in various bacterial proteins, including MotA/TolQ/ExbB proton channels and other transport proteins. The exact function of this set of domains has not, as yet, been determined.


Pssm-ID: 431055 [Multi-domain]  Cd Length: 84  Bit Score: 123.24  E-value: 4.33e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   392 DGSDIRFTESDGSTfLNYWIESWDPSNQTATIWVKV-NIPASTSKTIYMYYGNSSATSMSNGDSTFVFFDDFEGTSLNTT 470
Cdd:pfam10102    1 DGSDIRFTDSDGTT-LPYWIEPWDPTTGKALIWVKVpSIPANGNGTIYIYYGNPTATSTSNGDATFEFFDDFSGTALDTT 79


                   ....*
gi 505403041   471 KWATN 475
Cdd:pfam10102   80 KWTVV 84
DUF2341 pfam10102
Domain of unknown function (DUF2341); Members of this family are found in various bacterial ...
 797-870 8.88e-24

Domain of unknown function (DUF2341); Members of this family are found in various bacterial proteins, including MotA/TolQ/ExbB proton channels and other transport proteins. The exact function of this set of domains has not, as yet, been determined.


Pssm-ID: 431055 [Multi-domain]  Cd Length: 84  Bit Score: 96.66  E-value: 8.88e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505403041   797 DGSDIRFTESDGSTfLNYWIESWDPSNQTATIWVKV-NIPASTSKTIYMYYGNSSATSMSNPEKTMFLYENFESD 870
Cdd:pfam10102    1 DGSDIRFTDSDGTT-LPYWIEPWDPTTGKALIWVKVpSIPANGNGTIYIYYGNPTATSTSNGDATFEFFDDFSGT 74
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 259-344 2.12e-22

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 92.72  E-value: 2.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   259 NNPPVAAFTyTPATPLVGDIITFNASSSYDPDGDkITDYIWDFGDGDTATGVVTTHSYSSPGTYDVTLTVYDERGGVNST 338
Cdd:pfam18911    1 NAAPVADAG-GDRIVAEGETVTFDASASDDPDGD-ILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNST 78


                   ....*..
gi 505403041   339 -TVAIEV 344
Cdd:pfam18911   79 aTDTVTV 85
CARDB pfam07705
CARDB; Cell adhesion related domain found in bacteria.
 151-250 2.84e-17

CARDB; Cell adhesion related domain found in bacteria.


Pssm-ID: 400172 [Multi-domain]  Cd Length: 101  Bit Score: 78.47  E-value: 2.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   151 DLTISLKVSNANPEVNEEITIYADVMNVGSEDiNESFTVRFYYDSIEIYNEIINGLTSQSVEHISFSYTPTSTGQHVIKG 230
Cdd:pfam07705    3 DLIVQSISPPSEAYVGEENTITVTVKNQGTAA-AGAFNVALYVDGTSVGTITVPGLAAGESTTVSFSWTPPTEGSYTLTV 81

                           90       100
                   ....*....|....*....|
gi 505403041   231 VVDADGAIVEDNENNNVSSK 250
Cdd:pfam07705   82 VVDPDNTVAESNETNNELTK 101
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 670-738 2.43e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 74.73  E-value: 2.43e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505403041   670 TPSTPQVNEEITFNASSSTpsepgGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGR 738
Cdd:pfam00801    4 SGTVVAAGQPVTFTATLAD-----GSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGS 67
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 1083-1151 2.43e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 74.73  E-value: 2.43e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505403041  1083 TPSTPQVNEEITFNASSSTpsepgGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGR 1151
Cdd:pfam00801    4 SGTVVAAGQPVTFTATLAD-----GSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGS 67
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 665-748 3.30e-16

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 74.79  E-value: 3.30e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041    665 ADFTFTPSTPQVNEEITFNASSSTPsepgGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRqDSVTK 744
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTATSSDD----GSIVSYTWDFGDGTS--STGPTVTHTYTKPGTYTVTLTVTNAVGS-ASATV 74


                    ....
gi 505403041    745 QVEV 748
Cdd:smart00089   75 TVVV 78
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 1078-1161 3.30e-16

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 74.79  E-value: 3.30e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   1078 ADFTFTPSTPQVNEEITFNASSSTPsepgGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRqDSVTK 1157
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTATSSDD----GSIVSYTWDFGDGTS--STGPTVTHTYTKPGTYTVTLTVTNAVGS-ASATV 74


                    ....
gi 505403041   1158 QVEV 1161
Cdd:smart00089   75 TVVV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 663-748 5.45e-16

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 74.07  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  663 PTADFTFTPsTPQVNEEITFNASSStpsePGGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGRQDSV 742
Cdd:cd00146     1 PTASVSAPP-VAELGASVTFSASDS----SGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                  ....*.
gi 505403041  743 TKQVEV 748
Cdd:cd00146    76 TTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 1076-1161 5.45e-16

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 74.07  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1076 PTADFTFTPsTPQVNEEITFNASSStpsePGGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGRQDSV 1155
Cdd:cd00146     1 PTASVSAPP-VAELGASVTFSASDS----SGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                  ....*.
gi 505403041 1156 TKQVEV 1161
Cdd:cd00146    76 TTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 263-344 8.33e-16

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 73.64  E-value: 8.33e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041    263 VAAFTYTPATPLVGDIITFNASSSYDPDgdkITDYIWDFGDGDTATGVVTTHSYSSPGTYDVTLTVYDErGGVNSTTVAI 342
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTATSSDDGS---IVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNA-VGSASATVTV 76


                    ..
gi 505403041    343 EV 344
Cdd:smart00089   77 VV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 262-344 1.40e-12

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 64.44  E-value: 1.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  262 PVAAFTYTPATPLVGDIiTFNASSSYDPDgdkITDYIWDFGDG--DTATGVVTTHSYSSPGTYDVTLTVYDERGGVNSTT 339
Cdd:cd00146     1 PTASVSAPPVAELGASV-TFSASDSSGGS---IVSYKWDFGDGevSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKT 76


                  ....*
gi 505403041  340 VAIEV 344
Cdd:cd00146    77 TTVVV 81
COG3430 COG3430
Archaeal flagellin (archaellin), FlaG/FlaF family [Cell motility];
5-78 1.71e-11

Archaeal flagellin (archaellin), FlaG/FlaF family [Cell motility];


Pssm-ID: 442656  Cd Length: 91  Bit Score: 61.96  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041    5 MKFSGDDRAVSELISIILMIAITVgafsVIAVSIYSFL--------QTPPSKHADFQAEKIGDELVIYHTGGEELSGDDI 76
Cdd:COG3430     4 KKGMSDERAVSPVIGVILMVAITV----ILAAVIGVFVfglgddvsEPAPQASLSVEFVGDGDSVTITHEGGDPVNVDDL 79


                  ..
gi 505403041   77 II 78
Cdd:COG3430    80 KV 81
COG1572 COG1572
Serine protease, subtilase family [Posttranslational modification, protein turnover, ...
 151-282 1.73e-10

Serine protease, subtilase family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441180 [Multi-domain]  Cd Length: 459  Bit Score: 65.37  E-value: 1.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  151 DLTISLKVSNANPEVNEEITIYADVMNVGSEDInESFTVRFYYDSIEIYNEIINGLTSQSVEHISFSYT-PTSTGQHVIK 229
Cdd:COG1572   246 DLTVTSVTAPSTVVEGDTITVSATVKNQGTAAA-GATTVAFYLSGDPVGTASVGALAAGASYTVTVTITlPANAGTYYLL 324

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 505403041  230 GVVDADGAIVEDNENNNVSSKTISVSEPANNPPVAAFTYTPATPLVGDIITFN 282
Cdd:COG1572   325 AVVDPDNQVAESNETNNVASSAITVVGPPPPDLVVTSVSAPSTATAGSSVTVS 377
Pilin_N pfam07790
Archaeal Type IV pilin, N-terminal; This entry represents the N-terminal domain of archaeal ...
 12-78 3.27e-09

Archaeal Type IV pilin, N-terminal; This entry represents the N-terminal domain of archaeal pilins, which play important roles in surface adhesion and twitching motility. This domain contains an conserved N- terminal hydrophobic motif.


Pssm-ID: 400235  Cd Length: 78  Bit Score: 54.89  E-value: 3.27e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505403041    12 RAVSELISIILMIAITVGAFSVIAVSIYSFLQTPPSK-HADFQAEKI---GDELVIYHTGGEELSGDDIII 78
Cdd:pfam07790    1 DAVSPVIGVVLMLAITVILAAVIAVFVFGLASPPEKApQASIQVKYDssaDTGVTFEHKGGDPIDTKDLKI 71
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
1080-1386 1.17e-08

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 58.53  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1080 FTFTPSTPQVNEEITFNASSStpsepgGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRQDSVTKQV 1159
Cdd:COG3291     1 FTATPTSGCAPLTVQFTDTSS------GNATSYEWDFGDGTT--STEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1160 EVSETLFDPGFAYEDVNGNLMYDPGVDVQILASEIQDGVYDAGSNGLVIPPSVGDITASSIYFKGRDVVVSVDLTASKGV 1239
Cdd:COG3291    73 TVGAPNPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1240 EIIGSDSVDITGVSVSSTNYNRDVVIQAGKILANGTDITAHGEVFLKATNIYISDSTIDTSSEYNMKISIDATNYVFANN 1319
Cdd:COG3291   153 ATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTD 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505403041 1320 ATLKSQAKIDLGGNSLSGDGMSIDNSKAYDMKVNIVFLEDISLNNANIVSQGVVTINAGTQLTASDI 1386
Cdd:COG3291   233 VTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNV 299
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 224-750 3.36e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.94  E-value: 3.36e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   224 GQHVIKGVVDADGAIVEDNENNNVSSKTISVSEPANNPPVAAFTYTPATplVGDIIT------FNASSSYDPdgdkiTDY 297
Cdd:TIGR00864 1389 GAEVTFIYNDPGCYLVTVAASNNISAANDSALIEVLEPVGATSFKHNGS--HGNNLElgqpylFSAFGRARN-----ASY 1461

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   298 IWDFGDGDTATGVVTTHSYSSPGTYDVTLTVYDERGGvNSTTVAIEVIESIcelpgwdyrKAITItnqNSfSLTDyqikI 377
Cdd:TIGR00864 1462 LWDFGDGGLLEGPEILHAFNSPGDFNIRLAAANEVGK-NEATLNVAVKARV---------RGLTI---NA-SLTN----V 1523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   378 ELNSSnFDFTKANSDGSDIRFTesdgstflnyWI--ESWDPSNQTATIWVKVNiPASTSKTIYMYYGNSSATSmsngDST 455
Cdd:TIGR00864 1524 PLNGS-VHFEAHLDAGDDVRFS----------WIlcDHCTPIFGGNTIFYTFR-SVGTFNIIVTAENDVGAAQ----ASI 1587

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   456 FVFFddfegtslnttkwatntdtyQVENGAIRLWGSWNDGAylntrdsfsGSFVVEGRWRLSTTSKDVDLAVVFAEysns 535
Cdd:TIGR00864 1588 FLFV--------------------LQEIEGLQILGETAEGG---------GGGVQELDGCYFETNHTVQFHAGFKD---- 1634

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   536 ymwestsitctydsqstsrpyyqkdlnvkGTHVDWGpeiessdwqkfriiftqsyinyWDSWSAENSAKPSLEYSGSTFS 615
Cdd:TIGR00864 1635 -----------------------------GTNLSFS----------------------WNAILDNEPDGPAFAGSGKGAK 1663

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   616 TfylgiaadsdSTSRYGYIDyIFMRKyvenepSVVISATETDCTV----PSPTADFTFTPSTPQVNEEITFNASSStpse 691
Cdd:TIGR00864 1664 L----------NPLEAGPCD-IFLQA------ANLLGQATADCTIdflePAGNLMLAASDNPAAVNALINLSAELA---- 1722

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 505403041   692 pGGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGRQDSvTKQVEVLE 750
Cdd:TIGR00864 1723 -EGSGLQYRWFLEEGDDLETSEPFMSHSFPSAGLHLVTMKAFNELGSANA-SEEVDVQE 1779
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 1076-1231 3.47e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 3.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  1076 PTADFTFTPSTPQVNEEITFNASSsTPSePGGsiTNYHWDFGDGNVIDTTS-PTITHTYSSANTYSVTLTVTDSLgrqDS 1154
Cdd:TIGR00864 1088 PRVAIGTEDGLLLAGKPADFEAHP-LPS-PGG--IHYEWDFGDGSALLQGRqPAAAHTFAKRGPFHVCLEVNNTI---SG 1160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  1155 VTKQVEVsetlfdpgFAYEDVNGnLMYDPGVDVQILASEIQDGVYDAGSNgLVIPPSVGD--------ITASSIYFKGRD 1226
Cdd:TIGR00864 1161 AAACADM--------FAFEEIEG-LSADMSLATELGAATTVRAALQSGDN-ITWTFDMGDgkslsgpeATVEHKYAKAGN 1230


                   ....*
gi 505403041  1227 VVVSV 1231
Cdd:TIGR00864 1231 CTVNI 1235
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 663-736 2.94e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.84  E-value: 2.94e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505403041   663 PTADFTFTPSTPQVNEEITFNASSsTPSePGGsiTNYHWDFGDGNVIDTTS-PTITHTYSSANTYSVTLTVTDSL 736
Cdd:TIGR00864 1088 PRVAIGTEDGLLLAGKPADFEAHP-LPS-PGG--IHYEWDFGDGSALLQGRqPAAAHTFAKRGPFHVCLEVNNTI 1158
PHA01755 PHA01755
hypothetical protein
 359-635 6.68e-04

hypothetical protein


Pssm-ID: 222834  Cd Length: 562  Bit Score: 44.21  E-value: 6.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  359 AITITN-QNSFSLTDYQIKIELNSSNFdfTKANSDGSDIRF-TESDGSTFLNYWIESWDPSNQTATIWVK--VNIPASTS 434
Cdd:PHA01755  227 TITITNsQPDPTPSPFQQLLILNLSNI--ISSPSQLLNLQFcLDSQCSTPLYAWIESYNSNLSTVYIWINlpISIPANSS 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  435 KTIYMYYGNSSA---TSM-SNGDSTFVFFDD--------FEGTSLNTTKWATNTDTYQVEN--------GAIRLWGSWND 494
Cdd:PHA01755  305 ITIYMFVRNSIQypyTGMrPDLTSTYAQYDNgknvfliyFNGNEPLSNFNQEGNTIQQISTfgplgntiNAIYLSGYENN 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  495 GAYLNTRDSFSGSFVVegrwrlsTTSKDVDLAVVF----AEYSNSYMWESTSITCTYDSQST---SRPYYQKDLNVKGTh 567
Cdd:PHA01755  385 VGFVYTGKSETNQPVI-------SEASSQRMPNQTgglgAYNGTAGIADSTNTAFINDIGVTmgeDTSYFSQYYYVNGG- 456

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505403041  568 vdwgpeiESSDWQKFRIIFTQSYINYWdswsaensakpslEYSGSTFSTFYLGIAADSDSTSrYGYID 635
Cdd:PHA01755  457 -------ETGGSNYQGSAVSQWVYAWV-------------QYQGSSASSWFGCIAPQLYSSP-GGYCG 503
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 1107-1186 1.07e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  1107 GSITNYHWDFGDGNVIDttSPTITHTYSSANTYSVTLTVTDSLGRQDS---VTKQVEVSETLFDPGFAYEDVNGNLMYDP 1183
Cdd:TIGR00864 1456 ARNASYLWDFGDGGLLE--GPEILHAFNSPGDFNIRLAAANEVGKNEAtlnVAVKARVRGLTINASLTNVPLNGSVHFEA 1533


                   ...
gi 505403041  1184 GVD 1186
Cdd:TIGR00864 1534 HLD 1536
PHA01755 PHA01755
hypothetical protein
 747-850 2.19e-03

hypothetical protein


Pssm-ID: 222834  Cd Length: 562  Bit Score: 42.67  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  747 EVLEASVCELPGWdyrkAITITN-QNSFSLTDYQIKIELNSSNFdfTKANSDGSDIRF-TESDGSTFLNYWIESWDPSNQ 824
Cdd:PHA01755  214 ELIEFYVIPITAY----TITITNsQPDPTPSPFQQLLILNLSNI--ISSPSQLLNLQFcLDSQCSTPLYAWIESYNSNLS 287

                          90       100
                  ....*....|....*....|....*...
gi 505403041  825 TATIWVK--VNIPASTSKTIYMYYGNSS 850
Cdd:PHA01755  288 TVYIWINlpISIPANSSITIYMFVRNSI 315
BglS COG2273
Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];
455-514 9.97e-03

Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];


Pssm-ID: 441874 [Multi-domain]  Cd Length: 259  Bit Score: 39.59  E-value: 9.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  455 TFVFFDDFEGTSLNTTKWATNTD----------TYQ-----VENGAIRLWGSWND---------GAYLNTRDSFSGSFvv 510
Cdd:COG2273    30 TLVFSDEFDGTSLDTSKWTYDTGgpgwgngelqYYTdenvsVENGNLVITARKEPyggggrpytSGRITTKGKFSFTY-- 107


                  ....
gi 505403041  511 eGRW 514
Cdd:COG2273   108 -GRF 110
 
Name Accession Description Interval E-value
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 352-460 4.84e-40

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 156.99  E-value: 4.84e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  352 PGWDYRKAITI-TNQNSFSLTDYQIKIELNSSNFDFTKANSDGSDIRFTESDGSTFLNYWIESWDPSNQTATIWVKV-NI 429
Cdd:COG5306    26 PDWSYRKPITIdTTAIGGDLTDYPVLVRLHTGNFDFSSAKEDGSDIRFVAGDDKTPLKYWIEKFDPLNEMALVWVKVpSI 105

                          90       100       110
                  ....*....|....*....|....*....|.
gi 505403041  430 PASTSKTIYMYYGNSSATSMSNGDSTFVFFD 460
Cdd:COG5306   106 PAGAGTTIWLYYGNPKAPSASDGKGTFDFFD 136
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 757-860 5.66e-36

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 144.66  E-value: 5.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  757 PGWDYRKAITI-TNQNSFSLTDYQIKIELNSSNFDFTKANSDGSDIRFTESDGSTFLNYWIESWDPSNQTATIWVKV-NI 834
Cdd:COG5306    26 PDWSYRKPITIdTTAIGGDLTDYPVLVRLHTGNFDFSSAKEDGSDIRFVAGDDKTPLKYWIEKFDPLNEMALVWVKVpSI 105

                          90       100
                  ....*....|....*....|....*.
gi 505403041  835 PASTSKTIYMYYGNSSATSMSNPEKT 860
Cdd:COG5306   106 PAGAGTTIWLYYGNPKAPSASDGKGT 131
DUF2341 pfam10102
Domain of unknown function (DUF2341); Members of this family are found in various bacterial ...
 392-475 4.33e-33

Domain of unknown function (DUF2341); Members of this family are found in various bacterial proteins, including MotA/TolQ/ExbB proton channels and other transport proteins. The exact function of this set of domains has not, as yet, been determined.


Pssm-ID: 431055 [Multi-domain]  Cd Length: 84  Bit Score: 123.24  E-value: 4.33e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   392 DGSDIRFTESDGSTfLNYWIESWDPSNQTATIWVKV-NIPASTSKTIYMYYGNSSATSMSNGDSTFVFFDDFEGTSLNTT 470
Cdd:pfam10102    1 DGSDIRFTDSDGTT-LPYWIEPWDPTTGKALIWVKVpSIPANGNGTIYIYYGNPTATSTSNGDATFEFFDDFSGTALDTT 79


                   ....*
gi 505403041   471 KWATN 475
Cdd:pfam10102   80 KWTVV 84
DUF2341 pfam10102
Domain of unknown function (DUF2341); Members of this family are found in various bacterial ...
 797-870 8.88e-24

Domain of unknown function (DUF2341); Members of this family are found in various bacterial proteins, including MotA/TolQ/ExbB proton channels and other transport proteins. The exact function of this set of domains has not, as yet, been determined.


Pssm-ID: 431055 [Multi-domain]  Cd Length: 84  Bit Score: 96.66  E-value: 8.88e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505403041   797 DGSDIRFTESDGSTfLNYWIESWDPSNQTATIWVKV-NIPASTSKTIYMYYGNSSATSMSNPEKTMFLYENFESD 870
Cdd:pfam10102    1 DGSDIRFTDSDGTT-LPYWIEPWDPTTGKALIWVKVpSIPANGNGTIYIYYGNPTATSTSNGDATFEFFDDFSGT 74
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 259-344 2.12e-22

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 92.72  E-value: 2.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   259 NNPPVAAFTyTPATPLVGDIITFNASSSYDPDGDkITDYIWDFGDGDTATGVVTTHSYSSPGTYDVTLTVYDERGGVNST 338
Cdd:pfam18911    1 NAAPVADAG-GDRIVAEGETVTFDASASDDPDGD-ILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNST 78


                   ....*..
gi 505403041   339 -TVAIEV 344
Cdd:pfam18911   79 aTDTVTV 85
CARDB pfam07705
CARDB; Cell adhesion related domain found in bacteria.
 151-250 2.84e-17

CARDB; Cell adhesion related domain found in bacteria.


Pssm-ID: 400172 [Multi-domain]  Cd Length: 101  Bit Score: 78.47  E-value: 2.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   151 DLTISLKVSNANPEVNEEITIYADVMNVGSEDiNESFTVRFYYDSIEIYNEIINGLTSQSVEHISFSYTPTSTGQHVIKG 230
Cdd:pfam07705    3 DLIVQSISPPSEAYVGEENTITVTVKNQGTAA-AGAFNVALYVDGTSVGTITVPGLAAGESTTVSFSWTPPTEGSYTLTV 81

                           90       100
                   ....*....|....*....|
gi 505403041   231 VVDADGAIVEDNENNNVSSK 250
Cdd:pfam07705   82 VVDPDNTVAESNETNNELTK 101
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 670-738 2.43e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 74.73  E-value: 2.43e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505403041   670 TPSTPQVNEEITFNASSSTpsepgGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGR 738
Cdd:pfam00801    4 SGTVVAAGQPVTFTATLAD-----GSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGS 67
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 1083-1151 2.43e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 74.73  E-value: 2.43e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505403041  1083 TPSTPQVNEEITFNASSSTpsepgGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGR 1151
Cdd:pfam00801    4 SGTVVAAGQPVTFTATLAD-----GSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGS 67
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 665-748 3.30e-16

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 74.79  E-value: 3.30e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041    665 ADFTFTPSTPQVNEEITFNASSSTPsepgGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRqDSVTK 744
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTATSSDD----GSIVSYTWDFGDGTS--STGPTVTHTYTKPGTYTVTLTVTNAVGS-ASATV 74


                    ....
gi 505403041    745 QVEV 748
Cdd:smart00089   75 TVVV 78
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 1078-1161 3.30e-16

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 74.79  E-value: 3.30e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   1078 ADFTFTPSTPQVNEEITFNASSSTPsepgGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRqDSVTK 1157
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTATSSDD----GSIVSYTWDFGDGTS--STGPTVTHTYTKPGTYTVTLTVTNAVGS-ASATV 74


                    ....
gi 505403041   1158 QVEV 1161
Cdd:smart00089   75 TVVV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 663-748 5.45e-16

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 74.07  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  663 PTADFTFTPsTPQVNEEITFNASSStpsePGGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGRQDSV 742
Cdd:cd00146     1 PTASVSAPP-VAELGASVTFSASDS----SGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                  ....*.
gi 505403041  743 TKQVEV 748
Cdd:cd00146    76 TTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 1076-1161 5.45e-16

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 74.07  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1076 PTADFTFTPsTPQVNEEITFNASSStpsePGGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGRQDSV 1155
Cdd:cd00146     1 PTASVSAPP-VAELGASVTFSASDS----SGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                  ....*.
gi 505403041 1156 TKQVEV 1161
Cdd:cd00146    76 TTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 263-344 8.33e-16

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 73.64  E-value: 8.33e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041    263 VAAFTYTPATPLVGDIITFNASSSYDPDgdkITDYIWDFGDGDTATGVVTTHSYSSPGTYDVTLTVYDErGGVNSTTVAI 342
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTATSSDDGS---IVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNA-VGSASATVTV 76


                    ..
gi 505403041    343 EV 344
Cdd:smart00089   77 VV 78
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 1076-1155 7.86e-15

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 71.15  E-value: 7.86e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  1076 PTADFTFtPSTPQVNEEITFNASSSTPsePGGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRQDSV 1155
Cdd:pfam18911    4 PVADAGG-DRIVAEGETVTFDASASDD--PDGDILSYRWDFGDGTT--ATGANVSHTYAAPGTYTVTLTVTDDSGASNST 78
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 663-742 7.86e-15

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 71.15  E-value: 7.86e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   663 PTADFTFtPSTPQVNEEITFNASSSTPsePGGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRQDSV 742
Cdd:pfam18911    4 PVADAGG-DRIVAEGETVTFDASASDD--PDGDILSYRWDFGDGTT--ATGANVSHTYAAPGTYTVTLTVTDDSGASNST 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 262-344 1.40e-12

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 64.44  E-value: 1.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  262 PVAAFTYTPATPLVGDIiTFNASSSYDPDgdkITDYIWDFGDG--DTATGVVTTHSYSSPGTYDVTLTVYDERGGVNSTT 339
Cdd:cd00146     1 PTASVSAPPVAELGASV-TFSASDSSGGS---IVSYKWDFGDGevSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKT 76


                  ....*
gi 505403041  340 VAIEV 344
Cdd:cd00146    77 TTVVV 81
COG3430 COG3430
Archaeal flagellin (archaellin), FlaG/FlaF family [Cell motility];
5-78 1.71e-11

Archaeal flagellin (archaellin), FlaG/FlaF family [Cell motility];


Pssm-ID: 442656  Cd Length: 91  Bit Score: 61.96  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041    5 MKFSGDDRAVSELISIILMIAITVgafsVIAVSIYSFL--------QTPPSKHADFQAEKIGDELVIYHTGGEELSGDDI 76
Cdd:COG3430     4 KKGMSDERAVSPVIGVILMVAITV----ILAAVIGVFVfglgddvsEPAPQASLSVEFVGDGDSVTITHEGGDPVNVDDL 79


                  ..
gi 505403041   77 II 78
Cdd:COG3430    80 KV 81
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 266-337 8.75e-11

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 58.94  E-value: 8.75e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505403041   266 FTYTPATPLVGDIITFNASSSydpDGDkITDYIWDFGDGD--TATGVVTTHSYSSPGTYDVTLTVYDERGGVNS 337
Cdd:pfam00801    1 VSASGTVVAAGQPVTFTATLA---DGS-NVTYTWDFGDSPgtSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
COG1572 COG1572
Serine protease, subtilase family [Posttranslational modification, protein turnover, ...
 151-282 1.73e-10

Serine protease, subtilase family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441180 [Multi-domain]  Cd Length: 459  Bit Score: 65.37  E-value: 1.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  151 DLTISLKVSNANPEVNEEITIYADVMNVGSEDInESFTVRFYYDSIEIYNEIINGLTSQSVEHISFSYT-PTSTGQHVIK 229
Cdd:COG1572   246 DLTVTSVTAPSTVVEGDTITVSATVKNQGTAAA-GATTVAFYLSGDPVGTASVGALAAGASYTVTVTITlPANAGTYYLL 324

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 505403041  230 GVVDADGAIVEDNENNNVSSKTISVSEPANNPPVAAFTYTPATPLVGDIITFN 282
Cdd:COG1572   325 AVVDPDNQVAESNETNNVASSAITVVGPPPPDLVVTSVSAPSTATAGSSVTVS 377
Pilin_N pfam07790
Archaeal Type IV pilin, N-terminal; This entry represents the N-terminal domain of archaeal ...
 12-78 3.27e-09

Archaeal Type IV pilin, N-terminal; This entry represents the N-terminal domain of archaeal pilins, which play important roles in surface adhesion and twitching motility. This domain contains an conserved N- terminal hydrophobic motif.


Pssm-ID: 400235  Cd Length: 78  Bit Score: 54.89  E-value: 3.27e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505403041    12 RAVSELISIILMIAITVGAFSVIAVSIYSFLQTPPSK-HADFQAEKI---GDELVIYHTGGEELSGDDIII 78
Cdd:pfam07790    1 DAVSPVIGVVLMLAITVILAAVIAVFVFGLASPPEKApQASIQVKYDssaDTGVTFEHKGGDPIDTKDLKI 71
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
1080-1386 1.17e-08

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 58.53  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1080 FTFTPSTPQVNEEITFNASSStpsepgGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRQDSVTKQV 1159
Cdd:COG3291     1 FTATPTSGCAPLTVQFTDTSS------GNATSYEWDFGDGTT--STEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1160 EVSETLFDPGFAYEDVNGNLMYDPGVDVQILASEIQDGVYDAGSNGLVIPPSVGDITASSIYFKGRDVVVSVDLTASKGV 1239
Cdd:COG3291    73 TVGAPNPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041 1240 EIIGSDSVDITGVSVSSTNYNRDVVIQAGKILANGTDITAHGEVFLKATNIYISDSTIDTSSEYNMKISIDATNYVFANN 1319
Cdd:COG3291   153 ATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTD 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505403041 1320 ATLKSQAKIDLGGNSLSGDGMSIDNSKAYDMKVNIVFLEDISLNNANIVSQGVVTINAGTQLTASDI 1386
Cdd:COG3291   233 VTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNV 299
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 224-750 3.36e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.94  E-value: 3.36e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   224 GQHVIKGVVDADGAIVEDNENNNVSSKTISVSEPANNPPVAAFTYTPATplVGDIIT------FNASSSYDPdgdkiTDY 297
Cdd:TIGR00864 1389 GAEVTFIYNDPGCYLVTVAASNNISAANDSALIEVLEPVGATSFKHNGS--HGNNLElgqpylFSAFGRARN-----ASY 1461

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   298 IWDFGDGDTATGVVTTHSYSSPGTYDVTLTVYDERGGvNSTTVAIEVIESIcelpgwdyrKAITItnqNSfSLTDyqikI 377
Cdd:TIGR00864 1462 LWDFGDGGLLEGPEILHAFNSPGDFNIRLAAANEVGK-NEATLNVAVKARV---------RGLTI---NA-SLTN----V 1523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   378 ELNSSnFDFTKANSDGSDIRFTesdgstflnyWI--ESWDPSNQTATIWVKVNiPASTSKTIYMYYGNSSATSmsngDST 455
Cdd:TIGR00864 1524 PLNGS-VHFEAHLDAGDDVRFS----------WIlcDHCTPIFGGNTIFYTFR-SVGTFNIIVTAENDVGAAQ----ASI 1587

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   456 FVFFddfegtslnttkwatntdtyQVENGAIRLWGSWNDGAylntrdsfsGSFVVEGRWRLSTTSKDVDLAVVFAEysns 535
Cdd:TIGR00864 1588 FLFV--------------------LQEIEGLQILGETAEGG---------GGGVQELDGCYFETNHTVQFHAGFKD---- 1634

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   536 ymwestsitctydsqstsrpyyqkdlnvkGTHVDWGpeiessdwqkfriiftqsyinyWDSWSAENSAKPSLEYSGSTFS 615
Cdd:TIGR00864 1635 -----------------------------GTNLSFS----------------------WNAILDNEPDGPAFAGSGKGAK 1663

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   616 TfylgiaadsdSTSRYGYIDyIFMRKyvenepSVVISATETDCTV----PSPTADFTFTPSTPQVNEEITFNASSStpse 691
Cdd:TIGR00864 1664 L----------NPLEAGPCD-IFLQA------ANLLGQATADCTIdflePAGNLMLAASDNPAAVNALINLSAELA---- 1722

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 505403041   692 pGGSITNYHWDFGDGNVIDTTSPTITHTYSSANTYSVTLTVTDSLGRQDSvTKQVEVLE 750
Cdd:TIGR00864 1723 -EGSGLQYRWFLEEGDDLETSEPFMSHSFPSAGLHLVTMKAFNELGSANA-SEEVDVQE 1779
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
266-553 3.47e-08

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 57.37  E-value: 3.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  266 FTYTPATPLVGDIITFNASSSYDpdgdkITDYIWDFGDGDTATGVVTTHSYSSPGTYDVTLTVYDERGGVNSTTVAIEVI 345
Cdd:COG3291     1 FTATPTSGCAPLTVQFTDTSSGN-----ATSYEWDFGDGTTSTEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTITVG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  346 ESICELPGWDYRKAITITNQNSFSLTDYQIKIELNSSNFDFTKANSDGSDIRFTESDGSTFLNYWIESWDPSNQTATIWV 425
Cdd:COG3291    76 APNPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATV 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  426 KVNIPASTSKTIYMYYGNSSATSMSNGDSTFVFFDDFEGTSLNTTKWATNTDTYQVENGAIRLWGSWNDGAYLNTRDSFS 505
Cdd:COG3291   156 TTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTL 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 505403041  506 GSFVVEGRWRLSTTSKDVDLAVVFAEYSNSYMWESTSITCTYDSQSTS 553
Cdd:COG3291   236 TGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTN 283
COG1572 COG1572
Serine protease, subtilase family [Posttranslational modification, protein turnover, ...
 132-254 7.33e-08

Serine protease, subtilase family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441180 [Multi-domain]  Cd Length: 459  Bit Score: 56.90  E-value: 7.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  132 SEEANQVLFSMPAEALPEK-DLTISLKVSNANPEVNEEITIYADVMNVGSEDInESFTVRFYYDSIEIY-NEIINGLTSQ 209
Cdd:COG1572   336 SNETNNVASSAITVVGPPPpDLVVTSVSAPSTATAGSSVTVSVTVKNQGTAAA-SGFTVTLYLSGDATTdLTYVGSLAAG 414

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 505403041  210 SVEHISFSYTpTSTGQHVIKGVVDADGAIVEDNENNNVSSKTISV 254
Cdd:COG1572   415 ASYTVTISVT-TASGQYYLLVVADPDNYVGESNENNNVFAVSINV 458
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
667-982 1.36e-07

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 55.45  E-value: 1.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  667 FTFTPSTPQVNEEITFNASSStpsepgGSITNYHWDFGDGNVidTTSPTITHTYSSANTYSVTLTVTDSLGRQDSVTKQV 746
Cdd:COG3291     1 FTATPTSGCAPLTVQFTDTSS------GNATSYEWDFGDGTT--STEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  747 EVLEASVCELPGWDYRKAI-TITNQNSFSLTDYQIKIELNSSNFDFTKANSDGSDIRFTESDGSTFLNYWIESWDPSNQT 825
Cdd:COG3291    73 TVGAPNPGVTTVTTSTTVTtLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  826 ATIWVKVNIPASTSKTIYMYYGNSSATSMSNPEKTMFLYENFESDPGNLYGDAYYDSANRYVVLTRPLIFQTGYMVYNSV 905
Cdd:COG3291   153 ATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTD 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505403041  906 PTNPTGFYAKFYFKSGGGRGADALWMGAYDTDYTGTREDIVDGGYHFTYDEYNDRIAFTKSTTDNGAPIAYYSIDGS 982
Cdd:COG3291   233 VTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNVSTTADVTGGT 309
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 1076-1231 3.47e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 3.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  1076 PTADFTFTPSTPQVNEEITFNASSsTPSePGGsiTNYHWDFGDGNVIDTTS-PTITHTYSSANTYSVTLTVTDSLgrqDS 1154
Cdd:TIGR00864 1088 PRVAIGTEDGLLLAGKPADFEAHP-LPS-PGG--IHYEWDFGDGSALLQGRqPAAAHTFAKRGPFHVCLEVNNTI---SG 1160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  1155 VTKQVEVsetlfdpgFAYEDVNGnLMYDPGVDVQILASEIQDGVYDAGSNgLVIPPSVGD--------ITASSIYFKGRD 1226
Cdd:TIGR00864 1161 AAACADM--------FAFEEIEG-LSADMSLATELGAATTVRAALQSGDN-ITWTFDMGDgkslsgpeATVEHKYAKAGN 1230


                   ....*
gi 505403041  1227 VVVSV 1231
Cdd:TIGR00864 1231 CTVNI 1235
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 694-804 1.39e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   694 GSITNYHWDFGDGNVIDttSPTITHTYSSANTYSVTLTVTDSLGRQDSvTKQVEVLeASVcelpgwdyrKAITItnqNSf 773
Cdd:TIGR00864 1456 ARNASYLWDFGDGGLLE--GPEILHAFNSPGDFNIRLAAANEVGKNEA-TLNVAVK-ARV---------RGLTI---NA- 1518

                           90       100       110
                   ....*....|....*....|....*....|.
gi 505403041   774 SLTDyqikIELNSSnFDFTKANSDGSDIRFT 804
Cdd:TIGR00864 1519 SLTN----VPLNGS-VHFEAHLDAGDDVRFS 1544
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 663-736 2.94e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.84  E-value: 2.94e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505403041   663 PTADFTFTPSTPQVNEEITFNASSsTPSePGGsiTNYHWDFGDGNVIDTTS-PTITHTYSSANTYSVTLTVTDSL 736
Cdd:TIGR00864 1088 PRVAIGTEDGLLLAGKPADFEAHP-LPS-PGG--IHYEWDFGDGSALLQGRqPAAAHTFAKRGPFHVCLEVNNTI 1158
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 671-757 4.33e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.07  E-value: 4.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041   671 PSTPQVNEEITFNASSStpsePGGSITNYHWDFGDGNV-IDTTSPTITHTYSSANTYSVTLTVTDSLG---RQDSVTkqV 746
Cdd:TIGR00864 2051 PQDCFTNKMAQFEAATS----PKPNFMACHWDFGDGSAgQDTDEPRAEHEYLHPGDYRVQVNASNLVSffsAHAEIN--V 2124

                           90
                   ....*....|.
gi 505403041   747 EVLEasvCELP 757
Cdd:TIGR00864 2125 QVLA---CEEP 2132
PHA01755 PHA01755
hypothetical protein
 359-635 6.68e-04

hypothetical protein


Pssm-ID: 222834  Cd Length: 562  Bit Score: 44.21  E-value: 6.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  359 AITITN-QNSFSLTDYQIKIELNSSNFdfTKANSDGSDIRF-TESDGSTFLNYWIESWDPSNQTATIWVK--VNIPASTS 434
Cdd:PHA01755  227 TITITNsQPDPTPSPFQQLLILNLSNI--ISSPSQLLNLQFcLDSQCSTPLYAWIESYNSNLSTVYIWINlpISIPANSS 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  435 KTIYMYYGNSSA---TSM-SNGDSTFVFFDD--------FEGTSLNTTKWATNTDTYQVEN--------GAIRLWGSWND 494
Cdd:PHA01755  305 ITIYMFVRNSIQypyTGMrPDLTSTYAQYDNgknvfliyFNGNEPLSNFNQEGNTIQQISTfgplgntiNAIYLSGYENN 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  495 GAYLNTRDSFSGSFVVegrwrlsTTSKDVDLAVVF----AEYSNSYMWESTSITCTYDSQST---SRPYYQKDLNVKGTh 567
Cdd:PHA01755  385 VGFVYTGKSETNQPVI-------SEASSQRMPNQTgglgAYNGTAGIADSTNTAFINDIGVTmgeDTSYFSQYYYVNGG- 456

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505403041  568 vdwgpeiESSDWQKFRIIFTQSYINYWdswsaensakpslEYSGSTFSTFYLGIAADSDSTSrYGYID 635
Cdd:PHA01755  457 -------ETGGSNYQGSAVSQWVYAWV-------------QYQGSSASSWFGCIAPQLYSSP-GGYCG 503
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 1107-1186 1.07e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  1107 GSITNYHWDFGDGNVIDttSPTITHTYSSANTYSVTLTVTDSLGRQDS---VTKQVEVSETLFDPGFAYEDVNGNLMYDP 1183
Cdd:TIGR00864 1456 ARNASYLWDFGDGGLLE--GPEILHAFNSPGDFNIRLAAANEVGKNEAtlnVAVKARVRGLTINASLTNVPLNGSVHFEA 1533


                   ...
gi 505403041  1184 GVD 1186
Cdd:TIGR00864 1534 HLD 1536
PHA01755 PHA01755
hypothetical protein
 747-850 2.19e-03

hypothetical protein


Pssm-ID: 222834  Cd Length: 562  Bit Score: 42.67  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  747 EVLEASVCELPGWdyrkAITITN-QNSFSLTDYQIKIELNSSNFdfTKANSDGSDIRF-TESDGSTFLNYWIESWDPSNQ 824
Cdd:PHA01755  214 ELIEFYVIPITAY----TITITNsQPDPTPSPFQQLLILNLSNI--ISSPSQLLNLQFcLDSQCSTPLYAWIESYNSNLS 287

                          90       100
                  ....*....|....*....|....*...
gi 505403041  825 TATIWVK--VNIPASTSKTIYMYYGNSS 850
Cdd:PHA01755  288 TVYIWINlpISIPANSSITIYMFVRNSI 315
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 699-757 2.29e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 2.29e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505403041   699 YHWDFGDGNVIDTT--SPTITHTYSSANTYSVTLTVTDSLGRQDSVTkqvevleaSVCELP 757
Cdd:TIGR00864 1287 FDWSFGDGSPNETHhgCPGISHNFRGNGTFPLALTISSGVNKAHFFT--------QICVEP 1339
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 1112-1157 2.51e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 2.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 505403041  1112 YHWDFGDGNVIDTT--SPTITHTYSSANTYSVTLTVTDSLGRQDSVTK 1157
Cdd:TIGR00864 1287 FDWSFGDGSPNETHhgCPGISHNFRGNGTFPLALTISSGVNKAHFFTQ 1334
BglS COG2273
Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];
455-514 9.97e-03

Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];


Pssm-ID: 441874 [Multi-domain]  Cd Length: 259  Bit Score: 39.59  E-value: 9.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505403041  455 TFVFFDDFEGTSLNTTKWATNTD----------TYQ-----VENGAIRLWGSWND---------GAYLNTRDSFSGSFvv 510
Cdd:COG2273    30 TLVFSDEFDGTSLDTSKWTYDTGgpgwgngelqYYTdenvsVENGNLVITARKEPyggggrpytSGRITTKGKFSFTY-- 107


                  ....
gi 505403041  511 eGRW 514
Cdd:COG2273   108 -GRF 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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