NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|505392419|ref|WP_015579521|]
View 

MULTISPECIES: GntR family transcriptional regulator [Streptomyces]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
10-219 1.20e-46

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 153.54  E-value: 1.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  10 TVPKLERPGPLRERVYEALLELITTRALRPGQHLVESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEE 89
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  90 ADQLLSVRTLLEAEAARLAAAHSGRPGIEALEELCARGEQAVADDDVDLAVATNAAFHAKVMELAGNVVLSELAAQVDRR 169
Cdd:COG1802   82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRAR 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 505392419 170 VR--WYYTPVARQRGTRSWTEHRELIAAIASRDERRATEVMRAHTEHTRQTY 219
Cdd:COG1802  162 LRryRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
10-219 1.20e-46

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 153.54  E-value: 1.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  10 TVPKLERPGPLRERVYEALLELITTRALRPGQHLVESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEE 89
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  90 ADQLLSVRTLLEAEAARLAAAHSGRPGIEALEELCARGEQAVADDDVDLAVATNAAFHAKVMELAGNVVLSELAAQVDRR 169
Cdd:COG1802   82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRAR 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 505392419 170 VR--WYYTPVARQRGTRSWTEHRELIAAIASRDERRATEVMRAHTEHTRQTY 219
Cdd:COG1802  162 LRryRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 20-220 4.50e-17

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 76.98  E-value: 4.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  20 LRERVYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEE--------A 90
Cdd:PRK03837  14 LSEEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTiigqlsgmA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  91 DQLLS-----------VRTLLEAEAARLAAAHSGRPGIEALEELCARGEQAVadDDVDLAVATNAAFHAKVMELAGNVVL 159
Cdd:PRK03837  94 KDFLSqspdglahlkqARLFFESSLARYAAEHATDEQIALLRKALERNSQSL--GDNAAFIRSDMEFHRVIAEIPGNPIF 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505392419 160 selAAQVDRRVRW---YYTPVARQRGTRSWT--EHRELIAAIASRDERRATEVMRAHTEHTRQTYH 220
Cdd:PRK03837 172 ---MAIHEALLDWlieARPEVVILHGHENVTlqEHIAIVDAIRAHDPDEADRALQSHLNRVSALYH 234
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-82 4.43e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 69.78  E-value: 4.43e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505392419  19 PLRERVYEALLELITTRALRPGQHLV-ESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFV 82
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 20-82 1.87e-13

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 63.02  E-value: 1.87e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505392419   20 LRERVYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFV 82
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
24-82 7.10e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 58.74  E-value: 7.10e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419    24 VYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFV 82
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
10-219 1.20e-46

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 153.54  E-value: 1.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  10 TVPKLERPGPLRERVYEALLELITTRALRPGQHLVESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEE 89
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  90 ADQLLSVRTLLEAEAARLAAAHSGRPGIEALEELCARGEQAVADDDVDLAVATNAAFHAKVMELAGNVVLSELAAQVDRR 169
Cdd:COG1802   82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRAR 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 505392419 170 VR--WYYTPVARQRGTRSWTEHRELIAAIASRDERRATEVMRAHTEHTRQTY 219
Cdd:COG1802  162 LRryRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
16-220 3.97e-26

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 100.78  E-value: 3.97e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  16 RPGPLRERVYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEEADQLL 94
Cdd:COG2186    4 RRRSLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDPL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  95 SVRTLLEAEAARLAA---------------AHSGRPGIEALEELCARGEQAVadDDVDLAVATNAAFHAKVMELAGNVVL 159
Cdd:COG2186   84 ALLLALDDASLRDLLearlalepeaarlaaERATDEDLARLEAALAEMEAAA--DDGEAFAEADLAFHRAIAEASGNPLL 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505392419 160 SELAAQVDRRVRWY--YTPVARQRGTRSWTEHRELIAAIASRDERRATEVMRAHTEHTRQTYH 220
Cdd:COG2186  162 ALLLESLRELLRRSvrLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLR 224
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 20-220 4.50e-17

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 76.98  E-value: 4.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  20 LRERVYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEE--------A 90
Cdd:PRK03837  14 LSEEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTiigqlsgmA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  91 DQLLS-----------VRTLLEAEAARLAAAHSGRPGIEALEELCARGEQAVadDDVDLAVATNAAFHAKVMELAGNVVL 159
Cdd:PRK03837  94 KDFLSqspdglahlkqARLFFESSLARYAAEHATDEQIALLRKALERNSQSL--GDNAAFIRSDMEFHRVIAEIPGNPIF 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505392419 160 selAAQVDRRVRW---YYTPVARQRGTRSWT--EHRELIAAIASRDERRATEVMRAHTEHTRQTYH 220
Cdd:PRK03837 172 ---MAIHEALLDWlieARPEVVILHGHENVTlqEHIAIVDAIRAHDPDEADRALQSHLNRVSALYH 234
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-82 4.43e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 69.78  E-value: 4.43e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505392419  19 PLRERVYEALLELITTRALRPGQHLV-ESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFV 82
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 20-82 1.87e-13

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 63.02  E-value: 1.87e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505392419   20 LRERVYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFV 82
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
24-82 7.10e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 58.74  E-value: 7.10e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419    24 VYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFV 82
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 19-220 7.28e-12

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 62.86  E-value: 7.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  19 PLRERVYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEEADQLL--S 95
Cdd:PRK10421   2 RLSDEVADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETWSEQNIvqP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  96 VRTLLEAEAARLAAAHSGRPGIE----------ALEELCARGEQ---AVADDDVDLAVATNAAFHAKVMELAGNVVLSE- 161
Cdd:PRK10421  82 LKTLMADDPDYSFDILEARHAIEastawhaamrATPGDKEKIQLcfeATLSEDPDLASQADVRFHLAIAEASHNVVLLQt 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505392419 162 -------LAAQVDR-RVRWYYTPVARQRGTrswTEHRELIAAIASRDERRATEVMRAHTEHTRQTYH 220
Cdd:PRK10421 162 mrgffdvLQSSVKQsRQRMYLVPPVFSQLT---EQHQAVMDAILAGDAEGARKAMMAHLSFVHTTIK 225
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 105-214 2.29e-11

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 58.91  E-value: 2.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419   105 ARLAAAHSGRPGIEALEELCARGEQAV-ADDDVDLAVATNAAFHAKVMELAGNVVLSELAAQVDRRVRWYYTPVARQRgT 183
Cdd:smart00895  14 ARLAAERATDEDLAALEALLDAMEAAAaAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLRRLSLEAA-R 92

                           90       100       110
                   ....*....|....*....|....*....|.
gi 505392419   184 RSWTEHRELIAAIASRDERRATEVMRAHTEH 214
Cdd:smart00895  93 RALDEHRAILDAIRARDAEAARAAMREHLEA 123
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 92-210 2.31e-11

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 58.92  E-value: 2.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419   92 QLLSVRTLLEAEAARLAAAHSGRPGIEALEELCARGEQAVADDDVDLAVATNAAFHAKVMELAGNVVLSELAAQVDRRVR 171
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 505392419  172 WY--YTPVARQRGTRSWTEHRELIAAIASRDERRATEVMRA 210
Cdd:pfam07729  81 RLrrLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
PRK10225 PRK10225
Uxu operon transcriptional regulator;
30-217 2.18e-10

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 58.88  E-value: 2.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  30 ELITTRALRPGQHLV-ESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAE----EEAD----------QLL 94
Cdd:PRK10225  20 DLIIKTPYNPGERLPpEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGshntDSPDanvcndagpfELL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  95 SVRTLLEAEAARLAAAHSGRPGIEALEELCARGEQAVADDDVDLAVATNAAFHAKVMELAGNVVLSELAAQV----DRRV 170
Cdd:PRK10225 100 QARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQSwqwrENNP 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 505392419 171 RW--YYTPVARQRGTRSW-TEHRELIAAIASRDERRATEVMRAHTEHTRQ 217
Cdd:PRK10225 180 MWiqLHSHLDDSLYRKEWlGDHKQILAALIKKDARAAKLAMWQHLENVKQ 229
PRK11414 PRK11414
GntR family transcriptional regulator;
20-201 3.06e-10

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 57.96  E-value: 3.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  20 LRERVYEALLELITTRALRPGQHLVESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEEADQLLSVRTL 99
Cdd:PRK11414  12 LTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419 100 LEAEAARLAAAHSGRPGIEALEELCARGEQAVADDDVDLAVATNAAFHAKVMELAGNVVLSELAAQVDRR----VRWYY- 174
Cdd:PRK11414  92 LELMAVALAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPILCEMIEQLWVRmgpsLHYLYe 171

                        170       180
                 ....*....|....*....|....*....
gi 505392419 175 --TPVARQRGTRSWtehRELIAAIASRDE 201
Cdd:PRK11414 172 aiNPAELREHIENY---RLLLAALKAKDK 197
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
15-90 6.42e-10

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 57.18  E-value: 6.42e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505392419  15 ERPGPLRERVYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEEA 90
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYP 77
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 15-90 1.43e-08

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 54.06  E-value: 1.43e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505392419  15 ERPGPLRERVYEALLELITTRALRPGQHLVES-ELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEEA 90
Cdd:COG1167    8 DSSGPLYLQLADALREAILSGRLPPGDRLPSSrELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPA 84
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
24-211 1.27e-07

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 50.79  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  24 VYEALLE-LITTRALRPGQHLV-ESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEE-ADQLLSVRTLL 100
Cdd:PRK09464  14 VIEQQLEfLILEGTLRPGEKLPpERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSfSDPLVELLSDH 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419 101 EAEAARLAAAHSGRPGIEA--------------LEELCARGEQAVADDDVDLAVATNAAFHAKVMELAGNVVLSEL---- 162
Cdd:PRK09464  94 PESQFDLLETRHALEGIAAyyaalrgtdedferIRECHHAIELAQQSGDLDAEANAVMQYQIAVTEAAHNVVLLHLlrcm 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 505392419 163 AAQVDRRVRWYYTPVARQRG-TRSWTEHR-ELIAAIASRDERRATEVMRAH 211
Cdd:PRK09464 174 EPMLEQNVRQNFELLYRRREmLPKVSSHRaRIFEAIVAGKPEKAREASHRH 224
PRK14999 PRK14999
histidine utilization repressor; Provisional
 17-132 6.19e-06

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 45.69  E-value: 6.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  17 PGPLRERVYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEEAdqLLS 95
Cdd:PRK14999  10 PAPFYETVKQDICKKIAGGVWQPHDRIpSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSA--LFE 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 505392419  96 VRTlleAEAARLAAAHSGRPGIEALEELCARGEQAVA 132
Cdd:PRK14999  88 VRS---IAEEIAARRHQHRCEVLTLERVRANAIQASA 121
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
19-92 1.73e-05

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 42.47  E-value: 1.73e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505392419  19 PLRERVYEALLELITTRALRPGQHLvES--ELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEEADQ 92
Cdd:COG1725   10 PIYEQIADQIKEAIASGELKPGDRL-PSvrELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEE 84
PRK11402 PRK11402
transcriptional regulator PhoB;
19-96 4.96e-05

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 42.90  E-value: 4.96e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505392419  19 PLRERVYEALLELITTRALRPGQHL-VESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEEAdqLLSV 96
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIpTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENA--LLTV 85
PRK11523 PRK11523
transcriptional regulator ExuR;
23-217 9.47e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 39.44  E-value: 9.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  23 RVYEALLELITTRaLRPGQHLV------ESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFV------HEPAEEEA 90
Cdd:PRK11523   8 RLYQQLAAELKER-IEQGVYLVgdklpaERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVvsnqprHQQAADNN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  91 D--------QLLSVRTLLEAEAARLAAAHSGRPGIEALEEL--CARGEQAVADDDVDLavatnaAFHAKVMELAGNvvlS 160
Cdd:PRK11523  87 MefanygpfELLQARQLIESNIAEFAATQVTKQDIMKLMAIqeQARGEDCFRDSEWDL------QFHVQVALATQN---S 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505392419 161 ELAAQVDRR-VRWYYTPVAR-------QRGTRSWTE-HRELIAAIASRDERRATEVMRAHTEHTRQ 217
Cdd:PRK11523 158 ALAAIVEKMwTQRSHNPYWKklhehidDRTVDNWCDdHDQILKALIRKDPHAAKLAMWQHLENTKQ 223
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
45-71 5.26e-03

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 36.77  E-value: 5.26e-03
                         10        20
                 ....*....|....*....|....*..
gi 505392419  45 ESELAGHLGVSRQPVREALQRLNTEGW 71
Cdd:PRK04984  34 ERELSELIGVTRTTLREVLQRLARDGW 60
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 24-85 5.64e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 37.33  E-value: 5.64e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505392419  24 VYEALLELITTRALRPGQHLVE-SELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEP 85
Cdd:PRK15481  10 IFDSIRQLIQAGRLRPGDSLPPvRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGS 72
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 25-211 6.33e-03

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 36.80  E-value: 6.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419  25 YEALLELITTRALRPGQHLVESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPAEEEADQLLSVRTLLEAEA 104
Cdd:PRK11534  13 YRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAML 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505392419 105 ARLAAAHSG---RPGIEALEELCARGEQAVADDD-VDLAVATNAAFHAKVMELAGNVVL----SELAAQVDR-RVRWYYT 175
Cdd:PRK11534  93 VSLAIARGGdewEADVLAKAHLLSKLEACDASEKmLDEWDLRHQAFHTAIVAGCGSHYLlqmrERLFDLAARyRFIWLRR 172

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 505392419 176 PV-ARQRGTRSWTEHRELIAAIASRDERRATEVMRAH 211
Cdd:PRK11534 173 TVlSVEMLEDKHDQHQTLTAAILARDTARASELMRQH 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH