|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13054 |
PRK13054 |
lipid kinase; Reviewed |
2-299 |
0e+00 |
|
lipid kinase; Reviewed
Pssm-ID: 237281 [Multi-domain] Cd Length: 300 Bit Score: 520.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 2 ASYPDSLLILNGKSAGNDLLRQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDLN 81
Cdd:PRK13054 1 MTFPKSLLILNGKSAGNEELREAVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 82 TAHRPVMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNERTCFINMATGGFGTRITSETPEKLKAALGG 161
Cdd:PRK13054 81 GDARPALGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDRTYFINMATGGFGTRVTTETPEKLKAALGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 162 VSYLIHGLMRMDTLKPDSCEIHGENFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGQLQLRIFTGDG-LLPALFTTLT 240
Cdd:PRK13054 161 VAYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILPAPQeLLPTLLSTLT 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 241 QP-EESPNIIAGKSAWFEVIAPHGMTFNLDGEPLSGEKFRIEVVPGALQCRLPPDCQLLR 299
Cdd:PRK13054 241 GGsEDNPNIIRARLPWLEIQAPHELTFNLDGEPLSGRHFRIEVLPAALRCRLPPDCPLLR 300
|
|
| lip_kinase_YegS |
TIGR03702 |
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid ... |
7-298 |
3.55e-156 |
|
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid kinase family in the Proteobacteria. Bakali, et al. report phosphatidylglycerol kinase activity for the member from Escherichia coli, but refrain from calling that activity synonymous with its biological role. Note that a broader, subfamily-type model (TIGR00147), includes this family but also multiple paralogs in some species and varied functions. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 163414 Cd Length: 293 Bit Score: 437.62 E-value: 3.55e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 7 SLLILNGKSAGNDLLRQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDLNTAHRP 86
Cdd:TIGR03702 2 ALLILNGKQADNEDVREAVGDLRDEGIQLHVRVTWEKGDAQRYVAEALALGVSTVIAGGGDGTLREVATALAQIRDDAAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 87 VMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNERTCFINMATGGFGTRITSETPEKLKAALGGVSYLI 166
Cdd:TIGR03702 82 ALGLLPLGTANDFATAAGIPLEPAKALKLALNGAAQPIDLARVNGKHYFLNMATGGFGTRVTTETSEKLKKALGGAAYLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 167 HGLMRMDTLKPDSCEIHGENFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGQLQLRIFTGDGLLPALFTTLTQPEESP 246
Cdd:TIGR03702 162 TGLTRFSELTAASCEFRGPDFHWEGDFLALGIGNGRQAGGGQVLCPDALINDGLLDVRILPAPELLPATLSTLFGGDKNP 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 505385258 247 NIIAGKSAWFEVIAPHGMTFNLDGEPLSGEKFRIEVVPGALQCRLPPDCQLL 298
Cdd:TIGR03702 242 EFVRARLPWLEIEAPQPLTFNLDGEPLSGRHFRIEVLPGALRCHLPPGCPLL 293
|
|
| LCB5 |
COG1597 |
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ... |
8-294 |
3.31e-84 |
|
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];
Pssm-ID: 441205 [Multi-domain] Cd Length: 295 Bit Score: 254.78 E-value: 3.31e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 8 LLILN---GKSAGNDLLRQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDlntaH 84
Cdd:COG1597 6 LLIVNpasGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG----T 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 85 RPVMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNERtCFINMATGGFGTRITSETPEKLKAALGGVSY 164
Cdd:COG1597 82 GPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGR-YFLNVAGIGFDAEVVERANRALKRRLGKLAY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 165 LIHGLMRMDTLKPDSCEIHGENFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGQLQLRIFTGDGL--LPALFTTLT-- 240
Cdd:COG1597 161 VLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRlrLLRLLPRLLrg 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 505385258 241 QPEESPNIIAGKSAWFEVIAPHGMTFNLDGEPLSGEK-FRIEVVPGALQCRLPPD 294
Cdd:COG1597 241 RHLRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLATpLEFEVLPGALRVLVPAD 295
|
|
| DAGK_cat |
pfam00781 |
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ... |
8-129 |
9.73e-31 |
|
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.
Pssm-ID: 425868 [Multi-domain] Cd Length: 125 Bit Score: 111.91 E-value: 9.73e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 8 LLILN---GKSAGNDLLRQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDLntAH 84
Cdd:pfam00781 3 LVIVNpksGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGL--AT 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 505385258 85 RPVMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQV 129
Cdd:pfam00781 81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
|
|
| DAGKc |
smart00046 |
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ... |
8-131 |
1.02e-18 |
|
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.
Pssm-ID: 214487 [Multi-domain] Cd Length: 124 Bit Score: 80.03 E-value: 1.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 8 LLILNGKSAGNDLLRqAITELREDGARIHVRVTFEKGDAARyIDEGIRLG-AETIISGGGDGTINEIAGALIDLN-TAHR 85
Cdd:smart00046 1 LVFVNPKSGGGKGEK-LLRKFRLLLNPRQVFDLTKKGPAVA-LVIFRDVPdFNRVLVCGGDGTVGWVLNALDKRElPLPE 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 505385258 86 PVMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNE 131
Cdd:smart00046 79 PPVAVLPLGTGNDLARSLGWGGGYDGEKLLKTLRDALESDTVKLDR 124
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13054 |
PRK13054 |
lipid kinase; Reviewed |
2-299 |
0e+00 |
|
lipid kinase; Reviewed
Pssm-ID: 237281 [Multi-domain] Cd Length: 300 Bit Score: 520.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 2 ASYPDSLLILNGKSAGNDLLRQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDLN 81
Cdd:PRK13054 1 MTFPKSLLILNGKSAGNEELREAVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 82 TAHRPVMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNERTCFINMATGGFGTRITSETPEKLKAALGG 161
Cdd:PRK13054 81 GDARPALGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDRTYFINMATGGFGTRVTTETPEKLKAALGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 162 VSYLIHGLMRMDTLKPDSCEIHGENFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGQLQLRIFTGDG-LLPALFTTLT 240
Cdd:PRK13054 161 VAYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILPAPQeLLPTLLSTLT 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 241 QP-EESPNIIAGKSAWFEVIAPHGMTFNLDGEPLSGEKFRIEVVPGALQCRLPPDCQLLR 299
Cdd:PRK13054 241 GGsEDNPNIIRARLPWLEIQAPHELTFNLDGEPLSGRHFRIEVLPAALRCRLPPDCPLLR 300
|
|
| lip_kinase_YegS |
TIGR03702 |
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid ... |
7-298 |
3.55e-156 |
|
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid kinase family in the Proteobacteria. Bakali, et al. report phosphatidylglycerol kinase activity for the member from Escherichia coli, but refrain from calling that activity synonymous with its biological role. Note that a broader, subfamily-type model (TIGR00147), includes this family but also multiple paralogs in some species and varied functions. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 163414 Cd Length: 293 Bit Score: 437.62 E-value: 3.55e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 7 SLLILNGKSAGNDLLRQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDLNTAHRP 86
Cdd:TIGR03702 2 ALLILNGKQADNEDVREAVGDLRDEGIQLHVRVTWEKGDAQRYVAEALALGVSTVIAGGGDGTLREVATALAQIRDDAAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 87 VMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNERTCFINMATGGFGTRITSETPEKLKAALGGVSYLI 166
Cdd:TIGR03702 82 ALGLLPLGTANDFATAAGIPLEPAKALKLALNGAAQPIDLARVNGKHYFLNMATGGFGTRVTTETSEKLKKALGGAAYLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 167 HGLMRMDTLKPDSCEIHGENFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGQLQLRIFTGDGLLPALFTTLTQPEESP 246
Cdd:TIGR03702 162 TGLTRFSELTAASCEFRGPDFHWEGDFLALGIGNGRQAGGGQVLCPDALINDGLLDVRILPAPELLPATLSTLFGGDKNP 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 505385258 247 NIIAGKSAWFEVIAPHGMTFNLDGEPLSGEKFRIEVVPGALQCRLPPDCQLL 298
Cdd:TIGR03702 242 EFVRARLPWLEIEAPQPLTFNLDGEPLSGRHFRIEVLPGALRCHLPPGCPLL 293
|
|
| TIGR00147 |
TIGR00147 |
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ... |
1-291 |
1.06e-121 |
|
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 161732 [Multi-domain] Cd Length: 293 Bit Score: 350.27 E-value: 1.06e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 1 MASYPDSLLILNGKSAGNDLLRQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDL 80
Cdd:TIGR00147 1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 81 NtaHRPVMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNERTCFINMATGGFGTRITSETPEKLKAALG 160
Cdd:TIGR00147 81 D--DIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYCFINMAGGGFGTEITTETPEKLKAALG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 161 GVSYLIHGLMRMDTLKPDSCEIHGENFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGQLQLRIFTGDGLLPALFTTLT 240
Cdd:TIGR00147 159 SLSYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLM 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 505385258 241 QPE----ESPNIIAGKSAWFEVIAPHGMTFNLDGEPLSGEKFRIEVVPGALQCRL 291
Cdd:TIGR00147 239 SDEgkhtDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRCRL 293
|
|
| LCB5 |
COG1597 |
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ... |
8-294 |
3.31e-84 |
|
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];
Pssm-ID: 441205 [Multi-domain] Cd Length: 295 Bit Score: 254.78 E-value: 3.31e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 8 LLILN---GKSAGNDLLRQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDlntaH 84
Cdd:COG1597 6 LLIVNpasGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG----T 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 85 RPVMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNERtCFINMATGGFGTRITSETPEKLKAALGGVSY 164
Cdd:COG1597 82 GPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGR-YFLNVAGIGFDAEVVERANRALKRRLGKLAY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 165 LIHGLMRMDTLKPDSCEIHGENFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGQLQLRIFTGDGL--LPALFTTLT-- 240
Cdd:COG1597 161 VLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRlrLLRLLPRLLrg 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 505385258 241 QPEESPNIIAGKSAWFEVIAPHGMTFNLDGEPLSGEK-FRIEVVPGALQCRLPPD 294
Cdd:COG1597 241 RHLRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLATpLEFEVLPGALRVLVPAD 295
|
|
| PRK13337 |
PRK13337 |
putative lipid kinase; Reviewed |
40-271 |
3.07e-44 |
|
putative lipid kinase; Reviewed
Pssm-ID: 183982 [Multi-domain] Cd Length: 304 Bit Score: 152.51 E-value: 3.07e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 40 TFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDLNtaHRPVMGILPLGTANDFATSAGIPEDLGKALQLAILG 119
Cdd:PRK13337 40 TTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEKE--NRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 120 KATAVDIAQVNERTcFINMATGGFGTRITSETPEKLKAALGGVSYLIHGLMRMDTLKPDSCEIHGENFHWQGDALVIGIG 199
Cdd:PRK13337 118 HTVPVDIGKANNRY-FINIAGGGRLTELTYEVPSKLKTMLGQLAYYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLG 196
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505385258 200 NGRQAGGGQQLCPEALINDGQLQLRIFTGDGLLPAL-FTTLTQPEE---SPNIIAGKSAWFEVIAPHGMTFNLDGE 271
Cdd:PRK13337 197 LTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIhIATLALRGEhikHPKVIYTKANRIKVSSFDKMQLNLDGE 272
|
|
| PRK13057 |
PRK13057 |
lipid kinase; |
8-294 |
1.11e-36 |
|
lipid kinase;
Pssm-ID: 183857 [Multi-domain] Cd Length: 287 Bit Score: 132.35 E-value: 1.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 8 LLILNGKS-AGNDLLRQAITELREDGarihVRVTFEKGDAARYIDEGIRL---GAETIISGGGDGTINEIAGALIDLNTA 83
Cdd:PRK13057 1 LLLVNRHArSGRAALAAARAALEAAG----LELVEPPAEDPDDLSEVIEAyadGVDLVIVGGGDGTLNAAAPALVETGLP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 84 hrpvMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNERTcFINMATGGFGTRITSETPEKLKAALGGVS 163
Cdd:PRK13057 77 ----LGILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWVNGHY-FFNVASLGLSAELARRLTKELKRRWGTLG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 164 YLIHGLMRMDTLKPDSCEIHGENFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGQLQL---------RIFtgdGLLPA 234
Cdd:PRK13057 152 YAIAALRVLRRSRPFTAEIEHDGRTERVKTLQVAVGNGRYYGGGMTVAHDATIDDGRLDLyslevahwwRLL---ALLPA 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 235 LFTTlTQPeESPNIIAGKSAWFEVIAPHGMTFNLDGEPLSGEKFRIEVVPGALQCRLPPD 294
Cdd:PRK13057 229 LRRG-RHG-EWPDVRAFRTTELELRTRKPRPINTDGELTTYTPAHFRVLPKALRVLAPPP 286
|
|
| PRK13055 |
PRK13055 |
putative lipid kinase; Reviewed |
57-271 |
7.58e-33 |
|
putative lipid kinase; Reviewed
Pssm-ID: 237282 [Multi-domain] Cd Length: 334 Bit Score: 123.18 E-value: 7.58e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 57 GAETIISGGGDGTINEIAGALIDLNtaHRPVMGILPLGTANDFATSAGIP-EDLGKALQLAILGKATAVDIAQVNERTCF 135
Cdd:PRK13055 59 GFDLIIAAGGDGTINEVVNGIAPLE--KRPKMAIIPAGTTNDYARALKIPrDNPVEAAKVILKNQTIKMDIGRANEDKYF 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 136 INMATGGFGTRITSETPEKLKAALGGVSYLIHGLMRMDTLKPDSCEIHGENFHWQGDALVIGIGNGRQAGGGQQLCPEAL 215
Cdd:PRK13055 137 INIAAGGSLTELTYSVPSQLKSMFGYLAYLAKGAELLPRVSPVPVRITYDEGVFEGKISMFFLALTNSVGGFEQIVPDAK 216
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505385258 216 INDGQLQLrIFTGDGLLPALFTTLTQPE------ESPNIIAGKSAWFEV--IAPHGMTFNLDGE 271
Cdd:PRK13055 217 LDDGKFTL-IIVKTANLFELLHLMALILnggkhiDDPRVIYIKTSKLTIepLGDDRLMVNLDGE 279
|
|
| PRK00861 |
PRK00861 |
putative lipid kinase; Reviewed |
25-294 |
2.23e-31 |
|
putative lipid kinase; Reviewed
Pssm-ID: 234850 [Multi-domain] Cd Length: 300 Bit Score: 118.57 E-value: 2.23e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 25 ITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDLNTAhrpvMGILPLGTANDFATSAG 104
Cdd:PRK00861 25 IRAILEPEMDLDIYLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAVAGALIGTDIP----LGIIPRGTANAFAAALG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 105 IPEDLGKALQLAILGKATAVDIAQVNERTcFINMATGGFGTRITSETPEKLKAALGGVSYLIHGLMRMDTLKPDSCEIHG 184
Cdd:PRK00861 101 IPDTIEEACRTILQGKTRRVDVAYCNGQP-MILLAGIGFEAETVEEADREAKNRFGILAYILSGLQQLRELESFEVEIET 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 185 ENFHWQGDALVIGIGNGRQ-----AGGGQQLCPEalinDGQLQLRIFTGDGLLPALFTTLT--------QPEESPNIIAG 251
Cdd:PRK00861 180 EDQIITTNAVAVTVANAAPptsvlAQGPGAVIPD----DGLLDVTIVAPKNLAEAVAASYHllqtalqgNPAERDDIGYL 255
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 505385258 252 KSAWFEVIAPHGMTFNLDGEPLSGEKFRIEVVPGALQCRLPPD 294
Cdd:PRK00861 256 RAKQVKITTDPPQKVVIDGEVVGTTPIEIECLPRSLKVFAPLQ 298
|
|
| DAGK_cat |
pfam00781 |
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ... |
8-129 |
9.73e-31 |
|
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.
Pssm-ID: 425868 [Multi-domain] Cd Length: 125 Bit Score: 111.91 E-value: 9.73e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 8 LLILN---GKSAGNDLLRQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDLntAH 84
Cdd:pfam00781 3 LVIVNpksGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGL--AT 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 505385258 85 RPVMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQV 129
Cdd:pfam00781 81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
|
|
| PRK13059 |
PRK13059 |
putative lipid kinase; Reviewed |
38-288 |
5.75e-30 |
|
putative lipid kinase; Reviewed
Pssm-ID: 183858 Cd Length: 295 Bit Score: 114.75 E-value: 5.75e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 38 RVTFEKGDAAryIDEGIRLGAETIISGGGDGTINEIAGALIDLNTaHRPvMGILPLGTANDFATSAGIPEDLGKALQLAI 117
Cdd:PRK13059 39 RISLEYDLKN--AFKDIDESYKYILIAGGDGTVDNVVNAMKKLNI-DLP-IGILPVGTANDFAKFLGMPTDIGEACEQIL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 118 LGKATAVDIAQVNERTcFINMATGGFGTRITSETPEKLKAALGGVSYLIHGLMRMDTLKPDSCEIHGENFHWQGDALVIG 197
Cdd:PRK13059 115 KSKPKKVDLGKINDKY-FINVASTGLFTDVSQKTDVNLKNTIGKLAYYLKGLEELPNFRKLKVKVTSEEVNFDGDMYLML 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 198 IGNGRQAgGGQQLCPEALINDGQLQLRIFTGDGL--LPALFTTLTQPE---ESPNIIAGKSAWFEVIAPHGMTFNLDGEp 272
Cdd:PRK13059 194 VFNGQTA-GNFNLAYKAEVDDGLLDVIIIKACPIidLIPLFIKVLKGEhleDVNGLIYFKTDKLEIESNEEIVTDIDGE- 271
|
250
....*....|....*...
gi 505385258 273 lSGEKF--RIEVVPGALQ 288
Cdd:PRK13059 272 -RGPDFplNIECIKGGLK 288
|
|
| DAGKc |
smart00046 |
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ... |
8-131 |
1.02e-18 |
|
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.
Pssm-ID: 214487 [Multi-domain] Cd Length: 124 Bit Score: 80.03 E-value: 1.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 8 LLILNGKSAGNDLLRqAITELREDGARIHVRVTFEKGDAARyIDEGIRLG-AETIISGGGDGTINEIAGALIDLN-TAHR 85
Cdd:smart00046 1 LVFVNPKSGGGKGEK-LLRKFRLLLNPRQVFDLTKKGPAVA-LVIFRDVPdFNRVLVCGGDGTVGWVLNALDKRElPLPE 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 505385258 86 PVMGILPLGTANDFATSAGIPEDLGKALQLAILGKATAVDIAQVNE 131
Cdd:smart00046 79 PPVAVLPLGTGNDLARSLGWGGGYDGEKLLKTLRDALESDTVKLDR 124
|
|
| PRK12361 |
PRK12361 |
hypothetical protein; Provisional |
9-293 |
1.30e-14 |
|
hypothetical protein; Provisional
Pssm-ID: 183473 [Multi-domain] Cd Length: 547 Bit Score: 73.89 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 9 LILNGKSAG---NDLLRQAITELrEDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTINEIAGALIDLNTahr 85
Cdd:PRK12361 247 LIANPVSGGgkwQEYGEQIQREL-KAYFDLTVKLTTPEISAEALAKQARKAGADIVIACGGDGTVTEVASELVNTDI--- 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 86 pVMGILPLGTANDFA------TSAGIPedLGKALQLAILGKATAVDIAQVNERTCFINMATGGFGTRITSETPEKlKAAL 159
Cdd:PRK12361 323 -TLGIIPLGTANALShalfglGSKLIP--VEQACDNIIQGHTQRIDTARCNDRLMLLLVGIGFEQKMIESADRER-KNAL 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 160 GGVSYLiHGLMR---MD-----TLKPDSCEIHGENFHwqgdALVigIGNGRQA------GGGQqlcPEalINDGQLQLRI 225
Cdd:PRK12361 399 GQLAYL-DGLWRavnENetltlTVTLDDAEPQTISTH----SLV--VANAAPFtsllaqGGGE---PN--MTDGLLDITW 466
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505385258 226 FTGDGLLPA--------LFTTLTQPEESPNIIAGKSAWFEVIAPHGMTFNLDGEPLSGEKFRIEVVPGALQCRLPP 293
Cdd:PRK12361 467 LDSGGEPGEqllslaelALSGLGKEPEANKVHHAHAKKVTISSQKPIKYVIDGELFEDEDLTIEVQPASLKVFVPY 542
|
|
| PRK11914 |
PRK11914 |
diacylglycerol kinase; Reviewed |
22-288 |
2.86e-11 |
|
diacylglycerol kinase; Reviewed
Pssm-ID: 237021 [Multi-domain] Cd Length: 306 Bit Score: 62.88 E-value: 2.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 22 RQAITELREDGARIHVRVTFEKGDAARYIDEGIRLGAETIISGGGDGTIneiAGALIDLNTAHRPVmGILPLGTANDFAT 101
Cdd:PRK11914 29 ERAIARLHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGVI---SNALQVLAGTDIPL-GIIPAGTGNDHAR 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 102 SAGIP-EDLGKALQLAILGKATAVDIAQVNE----RTCFINMATGGFGTRITSETpEKLKAALGGVSYLIHGLMRMDTLK 176
Cdd:PRK11914 105 EFGIPtGDPEAAADVIVDGWTETVDLGRIQDddgiVKWFGTVAATGFDSLVTDRA-NRMRWPHGRMRYNLAMLAELSKLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 177 PDSCEIH---GENFhwQGDALVIGIGNGRQAGGGQQLCPEALINDGQLQLRIFTGDGL--LPALFTTLTQPE--ESPNII 249
Cdd:PRK11914 184 PLPFRLVldgTEEI--VTDLTLAAFGNTRSYGGGMLICPNADHTDGLLDITMVQSASRtrLLRLFPTVFKGThvELDEVS 261
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 505385258 250 AGKSAWFEVIAPhGMTFNLDGE---PLSGEkfrIEVVPGALQ 288
Cdd:PRK11914 262 TARAKTVHVECP-GINAYADGDfacPLPAE---ISAVPGALQ 299
|
|
| YegS_C |
pfam19279 |
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ... |
159-288 |
2.03e-06 |
|
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.
Pssm-ID: 437111 Cd Length: 158 Bit Score: 46.81 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505385258 159 LGGVSYLIHGLMRMDTLKPDSCEIH--GENFHWQGdALVIgIGNGRQAGGGQQLCPEALINDGQLQLRIFTGDG------ 230
Cdd:pfam19279 22 PGALSYPAAALRALATFRPLRYRVTvdGEVREFSA-ALVA-VANSGYYGGGMRIAPDARVDDGLLDVVVIEAASrrtllr 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505385258 231 LLPALFT----TLTQPEespnIIAGKSAwfEVIAPHGMTFNLDGEPLSGEKFRIEVVPGALQ 288
Cdd:pfam19279 100 LLPKVYDgrhvRLPQVE----VLRGREV--RIEADRPLPAGADGEVLGPLPVRVEVLPGALR 155
|
|
| |
