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Conserved domains on  [gi|505384189|ref|WP_015571291|]
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MULTISPECIES: GntR family transcriptional regulator [Enterobacter]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-244 7.38e-70

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 214.34  E-value: 7.38e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   6 KYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTAsniyilnNEKS 85
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKI-------EYPL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189  86 DSILGFSREFQGR-VNVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAILE 164
Cdd:COG2188   79 SRLTSFTEELRARgREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189 165 VGSLYGYIEDFTGKKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFRVKnMHIKR 244
Cdd:COG2188  159 TGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFV-VELRR 237
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-244 7.38e-70

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 214.34  E-value: 7.38e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   6 KYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTAsniyilnNEKS 85
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKI-------EYPL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189  86 DSILGFSREFQGR-VNVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAILE 164
Cdd:COG2188   79 SRLTSFTEELRARgREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189 165 VGSLYGYIEDFTGKKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFRVKnMHIKR 244
Cdd:COG2188  159 TGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFV-VELRR 237
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-236 2.95e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 125.02  E-value: 2.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   96 QGRVnVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAILEVGSLYGYIEDF 175
Cdd:pfam07702   2 QGRE-PKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505384189  176 TGKKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFR 236
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 6-236 1.18e-35

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 126.32  E-value: 1.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189    6 KYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTASNIYIlnneks 85
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPI------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   86 DSILGFSR--EFQGRVNVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAIL 163
Cdd:TIGR02404  75 SGITSFKElnETLGLDSKTEVVELDKEDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIA 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505384189  164 EvGSLYGYIEDFTGKKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFR 236
Cdd:TIGR02404 155 E-DSIYQYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFK 226
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-236 9.71e-33

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 116.24  E-value: 9.71e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189    96 QGRVnVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAILEvGSLYGYIEDF 175
Cdd:smart00866   2 QGRK-PTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLS-GSLYEYLEER 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505384189   176 TGKKISD---ADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFR 236
Cdd:smart00866  80 LGLKIVRstrAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
PRK09764 PRK09764
GntR family transcriptional regulator;
1-236 3.94e-31

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 114.93  E-value: 3.94e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   1 MEKKHKYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTAS-NIYI 79
Cdd:PRK09764   1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNyDIFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189  80 LNneksdsilGFSREFQGR-VNVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPhkvVATV 158
Cdd:PRK09764  81 LT--------SFDEKLSDRhVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMP---LALF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189 159 PQAILEV--GSLYGYIEDFTGKKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFR 236
Cdd:PRK09764 150 PDLTWQVmeNSKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-69 1.39e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 87.50  E-value: 1.39e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505384189   6 KYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFV 69
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-244 7.38e-70

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 214.34  E-value: 7.38e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   6 KYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTAsniyilnNEKS 85
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKI-------EYPL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189  86 DSILGFSREFQGR-VNVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAILE 164
Cdd:COG2188   79 SRLTSFTEELRARgREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189 165 VGSLYGYIEDFTGKKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFRVKnMHIKR 244
Cdd:COG2188  159 TGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFV-VELRR 237
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-236 2.95e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 125.02  E-value: 2.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   96 QGRVnVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAILEVGSLYGYIEDF 175
Cdd:pfam07702   2 QGRE-PKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505384189  176 TGKKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFR 236
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 6-236 1.18e-35

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 126.32  E-value: 1.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189    6 KYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTASNIYIlnneks 85
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPI------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   86 DSILGFSR--EFQGRVNVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAIL 163
Cdd:TIGR02404  75 SGITSFKElnETLGLDSKTEVVELDKEDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIA 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505384189  164 EvGSLYGYIEDFTGKKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFR 236
Cdd:TIGR02404 155 E-DSIYQYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFK 226
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-236 9.71e-33

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 116.24  E-value: 9.71e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189    96 QGRVnVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAILEvGSLYGYIEDF 175
Cdd:smart00866   2 QGRK-PTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLS-GSLYEYLEER 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505384189   176 TGKKISD---ADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFR 236
Cdd:smart00866  80 LGLKIVRstrAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
PRK09764 PRK09764
GntR family transcriptional regulator;
1-236 3.94e-31

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 114.93  E-value: 3.94e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   1 MEKKHKYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTAS-NIYI 79
Cdd:PRK09764   1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNyDIFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189  80 LNneksdsilGFSREFQGR-VNVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPhkvVATV 158
Cdd:PRK09764  81 LT--------SFDEKLSDRhVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMP---LALF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189 159 PQAILEV--GSLYGYIEDFTGKKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRADIFR 236
Cdd:PRK09764 150 PDLTWQVmeNSKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
PRK11402 PRK11402
transcriptional regulator PhoB;
7-233 1.07e-24

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 97.98  E-value: 1.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   7 YWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTASNIYILNNeksd 86
Cdd:PRK11402  11 YATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVS---- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189  87 silGFSrEF---QGRvnVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAIL 163
Cdd:PRK11402  87 ---GFT-DFgvsQGK--ATKEKVIEQERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYV 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505384189 164 EVGSLYGYI-EDFTGKKISDADSLieaDLF--DEELAAHLNILPGQPMLKITEVTRLDDGRAFNFSISYNRAD 233
Cdd:PRK11402 161 EGSSTYQLFqERFDTRVVSDKKTI---DIFaaTRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRAN 230
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-69 1.39e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 87.50  E-value: 1.39e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505384189   6 KYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFV 69
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 6-234 3.02e-18

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 80.59  E-value: 3.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   6 KYWEIKERIKKDiLNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTASniYILNNEKS 85
Cdd:PRK10079  13 RYQEIAAKLEQE-LRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYD--YPLNAQAR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189  86 dsilgFSREF--QGRvNVTSRLLTLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVVATVPQAiL 163
Cdd:PRK10079  90 -----FSQNLldQGS-HPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADLTWWPTLQR-F 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505384189 164 EVGSLYGYIEDFTGKKISDADSLIEADLFDEELAAHLNILPGQPMLKI-TEVTRLDDGRAFNFSISYNRADI 234
Cdd:PRK10079 163 DSGSLHDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVrTLNHRDGESSPAEYSVSLTRADM 234
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
10-69 6.54e-18

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 76.76  E-value: 6.54e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189  10 IKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFV 69
Cdd:COG1725   15 IADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFV 74
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 6-69 6.03e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 72.65  E-value: 6.03e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505384189    6 KYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFV 69
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
10-69 2.26e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 71.07  E-value: 2.26e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189    10 IKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFV 69
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 3-69 3.24e-15

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 74.09  E-value: 3.24e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505384189   3 KKHKYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFV 69
Cdd:COG1167   10 SGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFV 76
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
1-77 3.76e-15

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 71.89  E-value: 3.76e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505384189   1 MEKKHKYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTASNI 77
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWAL 79
PRK14999 PRK14999
histidine utilization repressor; Provisional
 7-215 6.49e-11

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 60.33  E-value: 6.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   7 YWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTASNIYILNNEKSD 86
Cdd:PRK14999  14 YETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSIAE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189  87 SILgfSREFQGRVNVTSrlltLTTLHADAALAQHLEIAQGDDVWFIRRIRLLDGQPVLIEDSNIPHKVV---------AT 157
Cdd:PRK14999  94 EIA--ARRHQHRCEVLT----LERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAvdyltqdyrQT 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 505384189 158 VPQAILEVGSlygyiedftgkKISDADSLIEADLFDEELAAHLNILPGQPMLKITEVT 215
Cdd:PRK14999 168 TPHAYLSRIA-----------PLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTT 214
PRK10225 PRK10225
Uxu operon transcriptional regulator;
3-76 1.25e-10

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 59.65  E-value: 1.25e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505384189   3 KKHKYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTASN 76
Cdd:PRK10225   7 AQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
12-69 8.77e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 51.08  E-value: 8.77e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 505384189  12 ERIKKDILNEVYKKGESIpSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFV 69
Cdd:COG1802   18 EALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV 74
PRK11523 PRK11523
transcriptional regulator ExuR;
1-83 1.46e-07

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 51.00  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   1 MEKKHKYWEIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTASNIYIL 80
Cdd:PRK11523   4 TEPRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQAA 83


                 ...
gi 505384189  81 NNE 83
Cdd:PRK11523  84 DNN 86
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 9-143 1.81e-06

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 47.71  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384189   9 EIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKNTASNIY--------IL 80
Cdd:PRK03837  17 EVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIIgqlsgmakDF 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505384189  81 NNEKSDSILGFSrefQGRVNVTSRLLTLTTLHAD----AALAQHLEI---AQGD-------DVWFIRRIRLLDGQPV 143
Cdd:PRK03837  97 LSQSPDGLAHLK---QARLFFESSLARYAAEHATdeqiALLRKALERnsqSLGDnaafirsDMEFHRVIAEIPGNPI 170
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 12-69 1.85e-06

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 47.45  E-value: 1.85e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 505384189  12 ERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFV 69
Cdd:PRK09990  14 ERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFV 71
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 9-69 1.10e-03

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 39.37  E-value: 1.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505384189   9 EIKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFV 69
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
10-72 2.33e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 38.46  E-value: 2.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505384189  10 IKERIKKDILNEVYKKGESIPSERDLASIYDVTRVTVQKAMAMLVQEGYIERIHGKGMFVLKN 72
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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