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Conserved domains on  [gi|505382832|ref|WP_015569934|]
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MULTISPECIES: HTH-type transcriptional activator RhaS [Enterobacter]

Protein Classification

HTH-type transcriptional activator RhaS( domain architecture ID 11486659)

HTH-type transcriptional activator RhaS is an AraC family transcriptional regulator that controls the expression of one or many genes with potentially diverse biological functions including metabolism, stress response, and virulence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
1-278 0e+00

HTH-type transcriptional activator RhaS;


:

Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 543.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832   1 MTVLHSVDFFPSGASPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLC 80
Cdd:PRK13503   1 MTVLHSVDFFPSGNAPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTLSGGTVCFVRDHDRHLYEHTDNLC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  81 LTNVLYRSPDAFQFLSGLNQLLPQEKDGHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQETHAIATRELLFMQLLVLLRRS 160
Cdd:PRK13503  81 LTNVLYRSPDAFRFLAGLNQLLPQEQDGQYPSHWRVNQSVLQQVRQLVAQMEQQEESNDLEAIASREILFMQLLVLLRKS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 161 SLVEGLENNDARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVT 240
Cdd:PRK13503 161 SLQENGENSDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVT 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 505382832 241 DIAYRCGFGDSNHFSTLFRREFNWSPRDIRQGKDALLQ 278
Cdd:PRK13503 241 DIAYRCGFGDSNHFSTLFRREFSWSPRDIRQGRDGFLQ 278
 
Name Accession Description Interval E-value
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
1-278 0e+00

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 543.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832   1 MTVLHSVDFFPSGASPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLC 80
Cdd:PRK13503   1 MTVLHSVDFFPSGNAPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTLSGGTVCFVRDHDRHLYEHTDNLC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  81 LTNVLYRSPDAFQFLSGLNQLLPQEKDGHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQETHAIATRELLFMQLLVLLRRS 160
Cdd:PRK13503  81 LTNVLYRSPDAFRFLAGLNQLLPQEQDGQYPSHWRVNQSVLQQVRQLVAQMEQQEESNDLEAIASREILFMQLLVLLRKS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 161 SLVEGLENNDARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVT 240
Cdd:PRK13503 161 SLQENGENSDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVT 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 505382832 241 DIAYRCGFGDSNHFSTLFRREFNWSPRDIRQGKDALLQ 278
Cdd:PRK13503 241 DIAYRCGFGDSNHFSTLFRREFSWSPRDIRQGRDGFLQ 278
cupin_RhaR_RhaS-like_N cd06977
HTH-type transcriptional activator RhaR and RhaS and related proteins, N-terminal cupin domain; ...
 16-147 6.64e-52

HTH-type transcriptional activator RhaR and RhaS and related proteins, N-terminal cupin domain; Members of this family contain an N-terminal cupin domain and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain, including the HTH-type transcription activators RhaS and RhaR. RhaS and RhaR respond to the availability of L-rhamnose and activate transcription of the operons in the Escherichia coli L-rhamnose catabolic regulon. The E. coli RhaR protein activates expression of the rhaSR operon in the presence of its effector, L-rhamnose. The resulting RhaS protein (plus L-rhamnose) activates expression of the L-rhamnose catabolic operon rhaBAD as well as the transport operon rhaT. These proteins bind DNA as dimers, via their HTH motifs. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380382 [Multi-domain]  Cd Length: 147  Bit Score: 166.67  E-value: 6.64e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  16 PVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLCLTNVLYRSPDAFQFL 95
Cdd:cd06977    3 PVAVEPRAPQEPFPEHTHDFHEIVIVTKGSGIHVLNGHPYRITAGDVFYIRPDDRHSYESVDDLCLTNILFRPERLFLFL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 505382832  96 SGLNQLLPQEKDgHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQETHAIATRE 147
Cdd:cd06977   83 DWLDTLPGYLAH-QFQSHWRLNSSTLREIRQLIDQLESELEERDAGSELMAE 133
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 169-271 7.46e-37

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 132.97  E-value: 7.46e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 169 NDARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGF 248
Cdd:COG4977  208 RDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGF 287

                         90       100
                 ....*....|....*....|...
gi 505382832 249 GDSNHFSTLFRREFNWSPRDIRQ 271
Cdd:COG4977  288 GSASHFRRAFRRRFGVSPSAYRR 310
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
190-270 1.19e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.95  E-value: 1.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832   190 WETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGFGDSNHFSTLFRREFNWSPRDI 269
Cdd:smart00342   4 LEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEY 83


                   .
gi 505382832   270 R 270
Cdd:smart00342  84 R 84
HTH_18 pfam12833
Helix-turn-helix domain;
193-271 2.12e-27

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 101.13  E-value: 2.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  193 LADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLL-RHTDESVTDIAYRCGFGDSNHFSTLFRREFNWSPRDIRQ 271
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
 
Name Accession Description Interval E-value
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
1-278 0e+00

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 543.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832   1 MTVLHSVDFFPSGASPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLC 80
Cdd:PRK13503   1 MTVLHSVDFFPSGNAPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTLSGGTVCFVRDHDRHLYEHTDNLC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  81 LTNVLYRSPDAFQFLSGLNQLLPQEKDGHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQETHAIATRELLFMQLLVLLRRS 160
Cdd:PRK13503  81 LTNVLYRSPDAFRFLAGLNQLLPQEQDGQYPSHWRVNQSVLQQVRQLVAQMEQQEESNDLEAIASREILFMQLLVLLRKS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 161 SLVEGLENNDARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVT 240
Cdd:PRK13503 161 SLQENGENSDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVT 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 505382832 241 DIAYRCGFGDSNHFSTLFRREFNWSPRDIRQGKDALLQ 278
Cdd:PRK13503 241 DIAYRCGFGDSNHFSTLFRREFSWSPRDIRQGRDGFLQ 278
cupin_RhaR_RhaS-like_N cd06977
HTH-type transcriptional activator RhaR and RhaS and related proteins, N-terminal cupin domain; ...
 16-147 6.64e-52

HTH-type transcriptional activator RhaR and RhaS and related proteins, N-terminal cupin domain; Members of this family contain an N-terminal cupin domain and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain, including the HTH-type transcription activators RhaS and RhaR. RhaS and RhaR respond to the availability of L-rhamnose and activate transcription of the operons in the Escherichia coli L-rhamnose catabolic regulon. The E. coli RhaR protein activates expression of the rhaSR operon in the presence of its effector, L-rhamnose. The resulting RhaS protein (plus L-rhamnose) activates expression of the L-rhamnose catabolic operon rhaBAD as well as the transport operon rhaT. These proteins bind DNA as dimers, via their HTH motifs. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380382 [Multi-domain]  Cd Length: 147  Bit Score: 166.67  E-value: 6.64e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  16 PVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLCLTNVLYRSPDAFQFL 95
Cdd:cd06977    3 PVAVEPRAPQEPFPEHTHDFHEIVIVTKGSGIHVLNGHPYRITAGDVFYIRPDDRHSYESVDDLCLTNILFRPERLFLFL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 505382832  96 SGLNQLLPQEKDgHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQETHAIATRE 147
Cdd:cd06977   83 DWLDTLPGYLAH-QFQSHWRLNSSTLREIRQLIDQLESELEERDAGSELMAE 133
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
3-271 3.11e-50

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 167.00  E-value: 3.11e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832   3 VLHSVDFFPSGASPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLCLT 82
Cdd:PRK13501   6 LLESRDYLLSEQMPVAVTNRYPQETFVEHTHQFCEIVIVWRGNGLHVLNDHPYRITCGDVFYIQAADHHSYESVHDLVLD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  83 NVLYrSPDAFQFLSGLNQLLPQEKDGHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQETHAIATREL---LFMQLLVLLRR 159
Cdd:PRK13501  86 NIIY-CPERLHLNAQWHKLLPPLGPEQNQGYWRLTTQGMAQARPIIQQLAQESRKTDSWSIQLTEVlllQLAIVLKRHRY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 160 SSLVEGLENNDARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESV 239
Cdd:PRK13501 165 RAEQAHLLPDGEQLDLIMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRI 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 505382832 240 TDIAYRCGFGDSNHFSTLFRREFNWSPRDIRQ 271
Cdd:PRK13501 245 SDIAARCGFEDSNYFSAVFTREAGMTPRDYRQ 276
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
8-271 3.33e-43

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 148.66  E-value: 3.33e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832   8 DFFPSGASPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLCLTNVLYr 87
Cdd:PRK13502  11 DFFTDEQQAVTVADRYPQDVFAEHTHEFCELVMVWRGNGLHVLNERPYRITRGDLFYIRAEDKHSYTSVNDLVLQNIIY- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  88 SPDAFQFLSGLNQLLPQEKDGHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQETHAIATRELLFMQLLVLLRRSSLVEG-- 165
Cdd:PRK13502  90 CPERLKLNVNWQAMIPGFQGAQWHPHWRLGSMGMNQARQVINQLEHESNGRDPLANEMAELLFGQLVMTLKRHRYATDdl 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 166 -LENNDARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAY 244
Cdd:PRK13502 170 pATSRETLLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISM 249

                        250       260
                 ....*....|....*....|....*..
gi 505382832 245 RCGFGDSNHFSTLFRREFNWSPRDIRQ 271
Cdd:PRK13502 250 QCGFEDSNYFSVVFTRETGMTPSQWRH 276
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
8-271 4.71e-39

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 138.70  E-value: 4.71e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832   8 DFFPSGASPVAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLCLTNVLYr 87
Cdd:PRK13500  41 DFFASDQQAVAVADRYPQDVFAEHTHDFCELVIVWRGNGLHVLNDRPYRITRGDLFYIHADDKHSYASVNDLVLQNIIY- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  88 SPDAFQFLSGLNQLLPQEKDGHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQETHAIATRELLFMQLLVLLRRSSLVEGL- 166
Cdd:PRK13500 120 CPERLKLNLDWQGAIPGFSASAGQPHWRLGSVGMAQARQVIGQLEHESSQHVPFANEMAELLFGQLVMLLNRHRYTSDSl 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 167 --ENNDARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAY 244
Cdd:PRK13500 200 ppTSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDIST 279

                        250       260
                 ....*....|....*....|....*..
gi 505382832 245 RCGFGDSNHFSTLFRREFNWSPRDIRQ 271
Cdd:PRK13500 280 ECGFEDSNYFSVVFTRETGMTPSQWRH 306
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 169-271 7.46e-37

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 132.97  E-value: 7.46e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 169 NDARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGF 248
Cdd:COG4977  208 RDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGF 287

                         90       100
                 ....*....|....*....|...
gi 505382832 249 GDSNHFSTLFRREFNWSPRDIRQ 271
Cdd:COG4977  288 GSASHFRRAFRRRFGVSPSAYRR 310
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
190-270 1.19e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.95  E-value: 1.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832   190 WETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGFGDSNHFSTLFRREFNWSPRDI 269
Cdd:smart00342   4 LEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEY 83


                   .
gi 505382832   270 R 270
Cdd:smart00342  84 R 84
HTH_18 pfam12833
Helix-turn-helix domain;
193-271 2.12e-27

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 101.13  E-value: 2.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  193 LADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLL-RHTDESVTDIAYRCGFGDSNHFSTLFRREFNWSPRDIRQ 271
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
25-272 3.69e-26

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 103.32  E-value: 3.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832  25 QAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLCLTNVLYRSPDAFQFLSGLNQLLPQ 104
Cdd:COG2207    8 LLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 105 EKDGHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQETHAIATRELLFMQLLVLLRRSSLVEGLENNDARLNQLMAWLEDHF 184
Cdd:COG2207   88 LLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 185 AEDVcwETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGFGDSNHFSTLFRREFNW 264
Cdd:COG2207  168 LLTL--EELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGV 245


                 ....*...
gi 505382832 265 SPRDIRQG 272
Cdd:COG2207  246 TPSEYRKR 253
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 165-272 5.47e-24

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 99.36  E-value: 5.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 165 GLENNDARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLrHTDESVTDIAY 244
Cdd:COG2169   78 GSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLL-QTGLSVTDAAY 156

                         90       100
                 ....*....|....*....|....*...
gi 505382832 245 RCGFGDSNHFSTLFRREFNWSPRDIRQG 272
Cdd:COG2169  157 AAGFGSLSRFYEAFKKLLGMTPSAYRRG 184
ftrA PRK09393
transcriptional activator FtrA; Provisional
 170-270 1.30e-17

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 81.16  E-value: 1.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 170 DARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGFG 249
Cdd:PRK09393 217 SDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFG 296

                         90       100
                 ....*....|....*....|.
gi 505382832 250 DSNHFSTLFRREFNWSPRDIR 270
Cdd:PRK09393 297 SEESLRHHFRRRAATSPAAYR 317
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 17-139 1.62e-16

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 74.01  E-value: 1.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832   17 VAIEPRLPQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTDNLCLT-NVLYRSPDAFQFL 95
Cdd:pfam02311   5 EGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRyRWLYFEPELLERI 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 505382832   96 SGLNQLLPqekdgHYPSHWRVNQSTLQQVRQLVSQMEQSEDGQE 139
Cdd:pfam02311  85 LADISILA-----GGPLPLLRDPELAALLRALFRLLEEAGRSDD 123
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 191-272 1.05e-12

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 66.98  E-value: 1.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 191 ETLADDFSLSLRTLHRQLKQHtGLTPQRYLNRLRLIKARHLLRH--TDESVTDIAYRCGFGDSNHFSTLFRREFNWSPRD 268
Cdd:PRK09685 218 EWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLRPaaDDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGE 296


                 ....
gi 505382832 269 IRQG 272
Cdd:PRK09685 297 YRRK 300
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
170-272 1.13e-09

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 57.68  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 170 DARLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGFG 249
Cdd:PRK10572 182 DPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYD 261

                         90       100
                 ....*....|....*....|...
gi 505382832 250 DSNHFSTLFRREFNWSPRDIRQG 272
Cdd:PRK10572 262 DQLYFSRVFKKCTGASPSEFRAR 284
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 193-268 1.44e-09

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 57.38  E-value: 1.44e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505382832 193 LADDFSLSLRTLHRQLKQHTGLTPQRYLNRlRLIKARHLLRHTDESVTDIAYRCGFGDSNHFSTLFRREFNWSPRD 268
Cdd:PRK15186 203 ISDSLYMSCSTLKRKLKQENTSFSEVYLNA-RMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSE 277
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
173-271 3.49e-08

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 50.69  E-value: 3.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 173 LNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGFGDSN 252
Cdd:PRK10219   7 IQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQ 86

                         90
                 ....*....|....*....
gi 505382832 253 HFSTLFRREFNWSPRDIRQ 271
Cdd:PRK10219  87 TFSRVFRRQFDRTPSDYRH 105
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
191-276 2.33e-07

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 51.33  E-value: 2.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 191 ETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHtDESVTDIAYRCGFGDSnhfSTLFR---REFNWSPR 267
Cdd:PRK15435 103 EALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAK-GESVTTSILNAGFPDS---SSYYRkadETLGMTAK 178


                 ....*....
gi 505382832 268 DIRQGKDAL 276
Cdd:PRK15435 179 QFRHGGENL 187
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 234-271 6.76e-07

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 45.22  E-value: 6.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 505382832  234 HTDESVTDIAYRCGFgDSNHFSTLFRREFNWSPRDIRQ 271
Cdd:pfam00165   6 STNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
24-74 2.37e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 45.22  E-value: 2.37e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 505382832  24 PQAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYE 74
Cdd:COG1917   32 PGARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFR 82
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
168-270 5.13e-06

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 45.09  E-value: 5.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 168 NNDA-RLNQLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRC 246
Cdd:PRK11511   5 NTDAiTIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERY 84

                         90       100
                 ....*....|....*....|....
gi 505382832 247 GFGDSNHFSTLFRREFNWSPRDIR 270
Cdd:PRK11511  85 GFESQQTLTRTFKNYFDVPPHKYR 108
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 180-221 9.90e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 41.76  E-value: 9.90e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 505382832  180 LEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLN 221
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
cupin_YbfI-like_N cd07001
AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal ...
 25-77 1.75e-05

AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators, including YbfI, an uncharacterized Bacillus subtilis. In Pseudomonas putida, this protein is thought to regulate the expression of phenylserine aldolase. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380405 [Multi-domain]  Cd Length: 76  Bit Score: 41.99  E-value: 1.75e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 505382832  25 QAAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRHLYEHTD 77
Cdd:cd07001   12 QKSFPNHFHDFYVIGFIESGQRTLFCEGKEYTVEPGDLLLINPRDVHSCIQIS 64
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 193-266 5.48e-05

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 43.83  E-value: 5.48e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505382832 193 LADDFSLSLRTLHRQLKQHTGLTPQRYLNRlRLIKARHLLRHTDESVTDIAYRCGFGDSNHFSTLFRREFNWSP 266
Cdd:PRK15185 228 VADHIFMSTSTLKRKLAEEGTSFSDIYLSA-RMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTP 300
PRK10371 PRK10371
transcriptional regulator MelR;
175-271 7.79e-04

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 40.19  E-value: 7.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 175 QLMAWLEDHFAEDVCWETLADDFSLSLRTLHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGFGDSNHF 254
Cdd:PRK10371 195 QMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRF 274

                         90
                 ....*....|....*..
gi 505382832 255 STLFRREFNWSPRDIRQ 271
Cdd:PRK10371 275 YSTFGKYVGMSPQQYRK 291
cupin_Lmo2851-like_N cd06996
AraC/XylS family transcriptional regulators similar to Listeria monocytogenes Lmo2851 protein, ...
 26-88 8.97e-04

AraC/XylS family transcriptional regulators similar to Listeria monocytogenes Lmo2851 protein, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included is Listeria monocytogenes Lmo2851 protein, whose function is unknown. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380400 [Multi-domain]  Cd Length: 87  Bit Score: 37.55  E-value: 8.97e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505382832  26 AAFPEHHHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRH-LYEHTDNLCLTNVLYRS 88
Cdd:cd06996   24 ADYPLHTHNFLEINYMYSGSCTQIVNGQEITLKEGDLLLLDQGSTHsIKALGEDDILINIIFRN 87
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 186-271 1.27e-03

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 39.30  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382832 186 EDVCwetlaDDFSLSLRTLHRQLKQHTGLTPQRYLNRlRLIKARHLLRhTDESVTDIAYRCGFGDSNHFSTLFRREFNWS 265
Cdd:PRK09940 154 KDIC-----DCLYISESLLKKKLKQEQTTFSQILLDA-RMQHAKNLIR-VEGSVNKIAEQCGYASTSYFIYAFRKHFGNS 226


                 ....*.
gi 505382832 266 PRDIRQ 271
Cdd:PRK09940 227 PKRVSK 232
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 204-271 1.35e-03

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 39.36  E-value: 1.35e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505382832 204 LHRQLKQHTGLTPQRYLNRLRLIKARHLLRHTDESVTDIAYRCGFGDSNHFSTLFRREFNWSPRDIRQ 271
Cdd:PRK10296 205 LTRATRRYYGKTPMQIINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRK 272
cupin_TM1287-like cd02221
Thermotoga maritima TM1287 decarboxylase, cupin domain; This family includes bacterial ...
 30-71 3.26e-03

Thermotoga maritima TM1287 decarboxylase, cupin domain; This family includes bacterial proteins homologous to TM1287 decarboxylase, a Thermotoga maritima manganese-containing cupin thought to catalyze the conversion of oxalate to formate and carbon dioxide, due to its similarity to oxalate decarboxylase (OXDC) from Bacillus subtilis. TM1287 shows a cupin fold with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.


Pssm-ID: 380350 [Multi-domain]  Cd Length: 93  Bit Score: 35.91  E-value: 3.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 505382832  30 EHHHDFhEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRH 71
Cdd:cd02221   36 QHEGEF-EIYYILSGEGLYTDNGKEYEVKAGDVTFTRDGESH 76
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
24-71 8.26e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 35.50  E-value: 8.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 505382832  24 PQAAFPEH-HHDFHEIVIVEHGTGIHVFNGQPYTISGGTVCFVRDHDRH 71
Cdd:COG0662   36 PGAELSLHvHPHRDEFFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPH 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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