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Conserved domains on  [gi|505339511|ref|WP_015526613|]
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MULTISPECIES: sulfurtransferase TusA family protein [Clostridia]

Protein Classification

sulfurtransferase TusA family protein( domain architecture ID 10001403)

sulfurtransferase TusA family protein similar to sulfurtransferase TusA, which interacts with cysteine desulfurase IscS and acts as the first member in a sulfur relay mechanism, transfering sulfur to the TusBCD complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 10-80 7.28e-18

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440194  Cd Length: 70  Bit Score: 70.22  E-value: 7.28e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505339511 10 VDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQILKLEDnEDGTYTLIVRKVE 80
Cdd:COG0425   1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELLSVEE-EGGVYRILIRKGG 70
 
Name Accession Description Interval E-value
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 10-80 7.28e-18

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 70.22  E-value: 7.28e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505339511 10 VDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQILKLEDnEDGTYTLIVRKVE 80
Cdd:COG0425   1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELLSVEE-EGGVYRILIRKGG 70
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 9-78 2.12e-17

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 68.74  E-value: 2.12e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505339511  9 TVDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQILKLEDnEDGTYTLIVRK 78
Cdd:cd00291   1 TLDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEVEE-EGGVYRILIRK 69
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 9-73 1.57e-15

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 64.13  E-value: 1.57e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505339511   9 TVDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQILKLEDnEDGTYT 73
Cdd:pfam01206  1 TLDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEVEE-EDGEYR 64
PRK11018 PRK11018
putative sulfurtransferase YedF;
1-78 1.71e-04

putative sulfurtransferase YedF;


Pssm-ID: 236822  Cd Length: 78  Bit Score: 36.18  E-value: 1.71e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505339511  1 MADIKIDDTVDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQILKLEdnEDG-TYTLIVRK 78
Cdd:PRK11018  2 MKNIVPDYRLDMVGEPCPYPAVATLEALPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQ--QDGpTIRYLIQK 78
selenium_YedF TIGR03527
selenium metabolism protein YedF; Members of this protein family are about 200 amino acids in ...
 10-78 2.39e-03

selenium metabolism protein YedF; Members of this protein family are about 200 amino acids in size, and include the uncharacterized YedF protein of Escherichia coli. This family shares an N-terminal domain, modeled by pfam01206, with the sulfurtransferase TusA (also called SirA). The C-terminal domain includes a typical redox-active disulfide motif, CGXC. This protein family found only among those genomes that also carry the selenium donor protein SelD, and its connection to selenium metabolism is indicated by the method of partial phylogenetic profiling vs. SelD. Its gene typically is found next to selD. Members of this family are found even when selenocysteine and selenouridine biosynthesis pathways are, except for SelD, completely absent, as in Enterococcus faecalis. Its role in selenium metabolism is unclear, but may include either detoxification or a role in labile selenoprotein biosynthesis.


Pssm-ID: 274630 [Multi-domain]  Cd Length: 194  Bit Score: 34.52  E-value: 2.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505339511   10 VDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQiLKLEDNEDGTYTLIVRK 78
Cdd:TIGR03527   1 IDARGLACPQPVILTKKALDELGEEGVLTVIVDNEAAKENVSKFATSLGYE-VEVEEKEEGYWILIIKK 68
 
Name Accession Description Interval E-value
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 10-80 7.28e-18

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 70.22  E-value: 7.28e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505339511 10 VDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQILKLEDnEDGTYTLIVRKVE 80
Cdd:COG0425   1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELLSVEE-EGGVYRILIRKGG 70
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 9-78 2.12e-17

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 68.74  E-value: 2.12e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505339511  9 TVDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQILKLEDnEDGTYTLIVRK 78
Cdd:cd00291   1 TLDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEVEE-EGGVYRILIRK 69
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 9-73 1.57e-15

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 64.13  E-value: 1.57e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505339511   9 TVDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQILKLEDnEDGTYT 73
Cdd:pfam01206  1 TLDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEVEE-EDGEYR 64
PRK11018 PRK11018
putative sulfurtransferase YedF;
1-78 1.71e-04

putative sulfurtransferase YedF;


Pssm-ID: 236822  Cd Length: 78  Bit Score: 36.18  E-value: 1.71e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505339511  1 MADIKIDDTVDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQILKLEdnEDG-TYTLIVRK 78
Cdd:PRK11018  2 MKNIVPDYRLDMVGEPCPYPAVATLEALPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQ--QDGpTIRYLIQK 78
selenium_YedF TIGR03527
selenium metabolism protein YedF; Members of this protein family are about 200 amino acids in ...
 10-78 2.39e-03

selenium metabolism protein YedF; Members of this protein family are about 200 amino acids in size, and include the uncharacterized YedF protein of Escherichia coli. This family shares an N-terminal domain, modeled by pfam01206, with the sulfurtransferase TusA (also called SirA). The C-terminal domain includes a typical redox-active disulfide motif, CGXC. This protein family found only among those genomes that also carry the selenium donor protein SelD, and its connection to selenium metabolism is indicated by the method of partial phylogenetic profiling vs. SelD. Its gene typically is found next to selD. Members of this family are found even when selenocysteine and selenouridine biosynthesis pathways are, except for SelD, completely absent, as in Enterococcus faecalis. Its role in selenium metabolism is unclear, but may include either detoxification or a role in labile selenoprotein biosynthesis.


Pssm-ID: 274630 [Multi-domain]  Cd Length: 194  Bit Score: 34.52  E-value: 2.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505339511   10 VDITDVVCPVTFVKAKVALEELDDGQILAIKMNDGEPVQNVPRSVKEEGHQiLKLEDNEDGTYTLIVRK 78
Cdd:TIGR03527   1 IDARGLACPQPVILTKKALDELGEEGVLTVIVDNEAAKENVSKFATSLGYE-VEVEEKEEGYWILIIKK 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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