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Conserved domains on  [gi|505240131|ref|WP_015427233|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Lactococcus]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-163 2.67e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 72.62  E-value: 2.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505240131   8 RVKRTRKLISQAFFGLLRKKKFEKISIQEIADSAMINRATFYAHYADKQDLYDSLIDQFLASFTGILDEqnLVDGNNVhV 87
Cdd:COG1309    3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEE--ALAAEDP-R 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505240131  88 KEIETVLSRFYEFVKDKPEVAQ-MITDRAHDQRLKNRFLEILSERYTELFEKLEVREKDVVVPNDFVISYISSILVG 163
Cdd:COG1309   80 ERLRALLRAYLEFLAENPALARlLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-163 2.67e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 72.62  E-value: 2.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505240131   8 RVKRTRKLISQAFFGLLRKKKFEKISIQEIADSAMINRATFYAHYADKQDLYDSLIDQFLASFTGILDEqnLVDGNNVhV 87
Cdd:COG1309    3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEE--ALAAEDP-R 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505240131  88 KEIETVLSRFYEFVKDKPEVAQ-MITDRAHDQRLKNRFLEILSERYTELFEKLEVREKDVVVPNDFVISYISSILVG 163
Cdd:COG1309   80 ERLRALLRAYLEFLAENPALARlLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 117-190 9.96e-06

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 42.99  E-value: 9.96e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505240131  117 DQRLKNRFLEILSERYTELFEKLEVREKDVVVPNDFVISYISSILVGTLDWWVSTSTQMSARDFAHLIIKLISN 190
Cdd:pfam14278  30 RESFERYLYELTKELILGVVEELSEGMNVSEEDKDFIADFYSYGFVGLILDWLENGMKESPEEIAELLSRLING 103
globin_sensor cd01068
Globin sensor domain of globin-coupled-sensors (GCSs), protoglobins (Pgbs), and sensor ...
 88-136 5.55e-03

Globin sensor domain of globin-coupled-sensors (GCSs), protoglobins (Pgbs), and sensor single-domain globins (SSDgbs); S family; This family includes sensor domains which binds porphyrins, and other non-heme cofactors. GCSs have an N-terminal sensor domain coupled to a functional domain. For heme-bound oxygen sensing/binding globin domains, O2 binds to/dissociates from the heme iron complex inducing a structural change in the sensor domain, which is then transduced to the functional domain, switching on (or off) the function of the latter. Functional domains include DGC/GGDEF, EAL, histidine kinase, MCP, PAS, and GAF domains. Characterized members include Bacillus subtilis heme-based aerotaxis transducer (HemAT-Bs) which has a sensor domain coupled to an MCP domain. HemAT-Bs mediates an aerophilic response, and may control the movement direction of bacteria and archaea. Its MCP domain interacts with the CheA histidine kinase, a component of the CheA/CheY signal transduction system that regulates the rotational direction of flagellar motors. Another GCS having the sensor domain coupled to an MCP domain is Caulobacter crescentus McpB. McpB is encoded by a gene which lies adjacent to the major chemotaxis operon. Like McpA (encoded on this operon), McpB has three potential methylation sites, a C-terminal CheBR docking motif, and a motif needed for proteolysis via a ClpX-dependent pathway during the swarmer-to-stalked cell transition. Also included is Geobacter sulfurreducens GCS, a GCS of unknown function, in which the sensor domain is coupled to a transmembrane signal-transduction domain. Pgbs are single-domain globins of unknown function. Methanosarcina acetivorans Pgbs is dimeric and has an N-terminal extension, which together with other Pgb-specific loops, buries the heme within the protein; small ligand molecules gain access to the heme via two orthogonal apolar tunnels. Pgbs and other single-domain globins can function as sensors, when coupled to an appropriate regulator domain.


Pssm-ID: 381256 [Multi-domain]  Cd Length: 146  Bit Score: 36.02  E-value: 5.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 505240131  88 KEIETVLSRFYEFVKDKPEVAQMITDRAHDQRLKNR----FLEILSERYTELF 136
Cdd:cd01068   25 PHLDEILDAFYDHLLSFPELAAIFDDHSTIERLKQTqrahWLELFSGDFDEAY 77
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-163 2.67e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 72.62  E-value: 2.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505240131   8 RVKRTRKLISQAFFGLLRKKKFEKISIQEIADSAMINRATFYAHYADKQDLYDSLIDQFLASFTGILDEqnLVDGNNVhV 87
Cdd:COG1309    3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEE--ALAAEDP-R 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505240131  88 KEIETVLSRFYEFVKDKPEVAQ-MITDRAHDQRLKNRFLEILSERYTELFEKLEVREKDVVVPNDFVISYISSILVG 163
Cdd:COG1309   80 ERLRALLRAYLEFLAENPALARlLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 117-190 9.96e-06

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 42.99  E-value: 9.96e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505240131  117 DQRLKNRFLEILSERYTELFEKLEVREKDVVVPNDFVISYISSILVGTLDWWVSTSTQMSARDFAHLIIKLISN 190
Cdd:pfam14278  30 RESFERYLYELTKELILGVVEELSEGMNVSEEDKDFIADFYSYGFVGLILDWLENGMKESPEEIAELLSRLING 103
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
23-62 2.81e-04

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 37.39  E-value: 2.81e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 505240131   23 LLRKKKFEKISIQEIADSAMINRATFYAHYADKQDLYDSL 62
Cdd:pfam00440   8 LFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
HTH_Tnp_1_2 pfam13022
Helix-turn-helix of insertion element transposase; This is a family of largely phage proteins ...
 23-115 1.85e-03

Helix-turn-helix of insertion element transposase; This is a family of largely phage proteins which are likely to be a helix-turn-helix insertion elements.


Pssm-ID: 404044 [Multi-domain]  Cd Length: 122  Bit Score: 36.71  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505240131   23 LLRKKKFEKISIQEIADSAMINRATFYaHYADKQDL---YDSLIDQFLASFTGILDEQ--NLVDGNNVHVKEIETVLSRF 97
Cdd:pfam13022  17 LLAENDYHTLTKDEIAEELGVSRSTLY-KWLRKKEFiayVNELAEEFLARFRAEVYKAlmRMILKGQPDVKAIELYFERR 95

                          90
                  ....*....|....*...
gi 505240131   98 YEFVkDKPEVAQMITDRA 115
Cdd:pfam13022  96 GELT-DKHQVEGKFEDVI 112
Protoglobin pfam11563
Protoglobin; This family includes protoglobin from Methanosarcina acetivorans C2A. It is also ...
 89-136 2.59e-03

Protoglobin; This family includes protoglobin from Methanosarcina acetivorans C2A. It is also found near the N-terminus of the Haem-based aerotactic transducer HemAT in Bacillus subtilis. It is part of the haemoglobin superfamily. Protoglobin has specific loops and an amino-terminal extension which leads to the burying of the haem within the matrix of the protein. Protoglobin-specific apolar tunnels allow the access of O2, CO and NO to the haem distal site. In HemAT it acts as an oxygen sensor domain. It can also recognize cyanide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 431935 [Multi-domain]  Cd Length: 149  Bit Score: 36.80  E-value: 2.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 505240131   89 EIETVLSRFYEFVKDKPEVAQMITDRAHDQRLKNRF----LEILSERYTELF 136
Cdd:pfam11563  31 HIPAIVDAFYDKLLSFPETARIFTTSSQIERLKDTLkaylLRLFSGPYDEAY 82
globin_sensor cd01068
Globin sensor domain of globin-coupled-sensors (GCSs), protoglobins (Pgbs), and sensor ...
 88-136 5.55e-03

Globin sensor domain of globin-coupled-sensors (GCSs), protoglobins (Pgbs), and sensor single-domain globins (SSDgbs); S family; This family includes sensor domains which binds porphyrins, and other non-heme cofactors. GCSs have an N-terminal sensor domain coupled to a functional domain. For heme-bound oxygen sensing/binding globin domains, O2 binds to/dissociates from the heme iron complex inducing a structural change in the sensor domain, which is then transduced to the functional domain, switching on (or off) the function of the latter. Functional domains include DGC/GGDEF, EAL, histidine kinase, MCP, PAS, and GAF domains. Characterized members include Bacillus subtilis heme-based aerotaxis transducer (HemAT-Bs) which has a sensor domain coupled to an MCP domain. HemAT-Bs mediates an aerophilic response, and may control the movement direction of bacteria and archaea. Its MCP domain interacts with the CheA histidine kinase, a component of the CheA/CheY signal transduction system that regulates the rotational direction of flagellar motors. Another GCS having the sensor domain coupled to an MCP domain is Caulobacter crescentus McpB. McpB is encoded by a gene which lies adjacent to the major chemotaxis operon. Like McpA (encoded on this operon), McpB has three potential methylation sites, a C-terminal CheBR docking motif, and a motif needed for proteolysis via a ClpX-dependent pathway during the swarmer-to-stalked cell transition. Also included is Geobacter sulfurreducens GCS, a GCS of unknown function, in which the sensor domain is coupled to a transmembrane signal-transduction domain. Pgbs are single-domain globins of unknown function. Methanosarcina acetivorans Pgbs is dimeric and has an N-terminal extension, which together with other Pgb-specific loops, buries the heme within the protein; small ligand molecules gain access to the heme via two orthogonal apolar tunnels. Pgbs and other single-domain globins can function as sensors, when coupled to an appropriate regulator domain.


Pssm-ID: 381256 [Multi-domain]  Cd Length: 146  Bit Score: 36.02  E-value: 5.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 505240131  88 KEIETVLSRFYEFVKDKPEVAQMITDRAHDQRLKNR----FLEILSERYTELF 136
Cdd:cd01068   25 PHLDEILDAFYDHLLSFPELAAIFDDHSTIERLKQTqrahWLELFSGDFDEAY 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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