|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
1-403 |
5.13e-160 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 457.76 E-value: 5.13e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 1 MAGTVIEWYEFFIYGTAAALVFSVTFFPNGgNPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGV 80
Cdd:cd17369 8 LVGTAIEWYDFFIYGTAAALVFNKLFFPAV-DPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 81 ATFLMGCLPDFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNF 160
Cdd:cd17369 87 ATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 161 LLSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEAlksQEENSHASTGLRTVITQYPKQLAVATAVRIGENAM 240
Cdd:cd17369 167 LLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRA---KEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 241 YYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIII 320
Cdd:cd17369 244 FYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 321 LFAVIFGLVV-QSFMYGPEGALFGELFPTRARYAGVSAAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSI 399
Cdd:cd17369 324 VLAAVVVLGVlHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISL 403
|
....
gi 505212428 400 FSMV 403
Cdd:cd17369 404 VAAL 407
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
3-391 |
7.49e-120 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 355.04 E-value: 7.49e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 3 GTVIEWYEFFIYGTAAALVFSvTFFPNGGNPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVAT 82
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFH-TFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 83 FLMGCLPDFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNFLL 162
Cdd:TIGR00883 80 LLIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 163 SEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEALKSQEEnshASTGLRTVITQYPKQLAVATAVRIGENAMYY 242
Cdd:TIGR00883 160 GDDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKK---KRGPIAETLTKHRKPFLLGLGLVIATTTTFY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 243 LIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALV-WAPFYFPLLNTGSFIIIL 321
Cdd:TIGR00883 237 LITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALlAVPLLMALLDSGSFTLFF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 322 FAVIFGLVVQSFMYGPEGALFGELFPTRARYAGVSAAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYL 391
Cdd:TIGR00883 317 FLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYL 386
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
2-391 |
1.05e-86 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 271.61 E-value: 1.05e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 2 AGTVIEWYEFFIYGTAAALVFSVTFFPNGGnPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVA 81
Cdd:PRK09952 29 AGAVVDWYDFLLYGITAALVFNREFFPQVS-PAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMGIA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 82 TFLMGCLPDFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLAT-IVLLGSNf 160
Cdd:PRK09952 108 TALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTgLVSLISM- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 161 LLSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEAlksQEENSHASTGLRTV--ITQYPKQLAVATAVRIGEN 238
Cdd:PRK09952 187 MTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQ---QHEQAAAKKRIPVIeaLLRHPGAFLKIIALRLCEL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 239 AMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWA-PFYFPLLNTGSF 317
Cdd:PRK09952 264 LTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAfPFFMALEAQSIF 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505212428 318 IIILFAVIFGLVVQSFMYGPEGALFGELFPTRARYAGVSAAYQLGSILGGSLAPIIAVFLWNTFD-SWIPIAIYL 391
Cdd:PRK09952 344 WIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTYFGgSWHSVAIYL 418
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
2-398 |
7.69e-72 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 232.19 E-value: 7.69e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 2 AGTVIEWYEFFIYGtAAALVFSVTFFPnGGNPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVA 81
Cdd:cd17367 6 VGNLVEWYDWYVYA-AFALYFAPQFFP-SGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 82 TFLMGCLPDFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNFL 161
Cdd:cd17367 84 SLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 162 LSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEALKSQEenshASTGLRTVITQYPKQLAVATAVRIGENAMY 241
Cdd:cd17367 164 LGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNE----ASAGTLRELRRHPRELLLVVGLTAGGTLAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 242 YLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLL-NTGSFIII 320
Cdd:cd17367 240 YTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALdHTDSPYTA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505212428 321 LFAVIFGLVVQSFMYGPEGALFGELFPTRARYAGVSAAYQLG-SILGGSlAPIIAVFLWNTFDSWIpIAIYLFTLLAFS 398
Cdd:cd17367 320 FALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAvAIFGGT-APYVALWLKSIGHEWV-FFWYVAGLIAIS 396
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
3-410 |
1.68e-63 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 212.65 E-value: 1.68e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 3 GTVIEWYEFFIYGTAAALVFSVtFFPnGGNPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVAT 82
Cdd:PRK10642 24 GNAMEWFDFGVYGFVAYALGKV-FFP-GADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSIST 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 83 FLMGCLPDFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNFLL 162
Cdd:PRK10642 102 FCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTIV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 163 SEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEALKSQEENSHAS------TGLRTVITQYPKQLAVATAVRIG 236
Cdd:PRK10642 182 GEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDREGlqdgpkVSFKEIATKHWRSLLTCIGLVIA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 237 ENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGS 316
Cdd:PRK10642 262 TNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVLAIPAFILINSNV 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 317 FIIILFAVIFGLVVQSFMYGPEGALFGELFPTRARYAGVSAAYQLgSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLA 396
Cdd:PRK10642 342 IGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNI-SVLVAGLTPTLAAWLVESTQNLMMPAYYLMVVAV 420
|
410
....*....|....
gi 505212428 397 FSIFSMVYgVKETS 410
Cdd:PRK10642 421 IGLITGVT-MKETA 433
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
3-410 |
2.59e-62 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 206.44 E-value: 2.59e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 3 GTVIEWYEFFIYGTAAALVFSVtFFPnGGNPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVAT 82
Cdd:cd17366 7 GNAMEWFDFGVYGYLAVTIGKV-FFP-GGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAAST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 83 FLMGCLPDFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNFLL 162
Cdd:cd17366 85 FCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 163 SEEAFLAWGWRIAFWLSAVVVFIGYYIRkkvedapifkealksqeenshastglrtvitqypKQLAVATAVRIGENAMYY 242
Cdd:cd17366 165 TEAQMLDWGWRIPFLIAAPLGLVGLYLR----------------------------------RPLLICIGLVLVFNVTNY 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 243 LIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSfiiiLF 322
Cdd:cd17366 211 MLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGS----IA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 323 AVIFGLVVQSFMY----GPEGALFGELFPTRARYAGVSAAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFS 398
Cdd:cd17366 287 AIFIGLLVLGLLLscytATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAVVG 366
|
410
....*....|..
gi 505212428 399 IFSMVYgVKETS 410
Cdd:cd17366 367 LVAVLF-LTETA 377
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
3-403 |
1.19e-61 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 203.99 E-value: 1.19e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 3 GTVIEWYEFFIYGTAAALVFSVtffpngGNPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVAT 82
Cdd:cd17316 7 GWFFDAYDFFLIGFVAPVLAAE------FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 83 FLMGCLPDfsvwgyaaPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLlgsnFLL 162
Cdd:cd17316 81 LLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVA----SLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 163 SEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVedapifkealksqeenshastglrtvitqypkqlAVATAVRIGENAMYY 242
Cdd:cd17316 149 IPLLSGDWGWRILFLIGALPALLALLLRRRT----------------------------------LLLILLWFFISFGYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 243 LIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIIILF 322
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 323 AVIFGLVVQSFmYGPEGALFGELFPTRARYAGVSAAYQLGSILGGSLAPIIAVFLWNTfDSWIPIAIYLFTLLAFSIFSM 402
Cdd:cd17316 275 LFILSFFVGGV-WGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST-GGTGVPALILALLAIVALIVA 352
|
.
gi 505212428 403 V 403
Cdd:cd17316 353 L 353
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
2-404 |
4.85e-57 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 193.36 E-value: 4.85e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 2 AGTVIEWYEFFIYGTAAALVfSVTFFPNGgNPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVA 81
Cdd:cd17368 6 SGNALEFFDFGVYGFFAVYI-GRLFFPSG-SEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 82 TFLMGCLPDFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNFL 161
Cdd:cd17368 84 TLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 162 LSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEALKSQEenshaSTGLRTVITQYPKQLAVATAVRIGENAMY 241
Cdd:cd17368 164 LTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPT-----RRELFALLANNRRIILLGMLLVAGSTVTF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 242 YLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWA-PFYFPLLNTGSFIII 320
Cdd:cd17368 239 YFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLyPVFAWLTAAPSFGRL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 321 LFAVIFGLVVQSFMYGPEGALFGELFPTRARYAGVSAAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIF 400
Cdd:cd17368 319 LLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLL 398
|
....
gi 505212428 401 SMVY 404
Cdd:cd17368 399 ATLM 402
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
2-377 |
4.00e-46 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 164.98 E-value: 4.00e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 2 AGTVIEWYEFFIYgTAAALVFSVTFFPNGgNPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVA 81
Cdd:PRK10406 29 SGNLVEWFDFYVY-SFCSLYFAHIFFPSG-NTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMMCFG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 82 TFLMGCLPDFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNFL 161
Cdd:PRK10406 107 SLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQQT 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 162 LSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDApifkealKSQEENSHASTGLRTVITQYPKQLAVATAVRIGENAMY 241
Cdd:PRK10406 187 LEDAELREWGWRIPFALGAVLAVVALWLRRQLDET-------SQQETRALKEAGSLKGLWRNRRAFIMVLGFTAAGSLCF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 242 YLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLI-GGVLALVWAPFYFPLLNTGSFIII 320
Cdd:PRK10406 260 YTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCfGSLAALFTVPILSALQNVSSPYAA 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 505212428 321 LFAVIFGLVVQSFMYGPEGALFGELFPTRARYAGVSAAYQLGSILGGSLAPIIAVFL 377
Cdd:PRK10406 340 FGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSL 396
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
1-377 |
3.26e-42 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 154.72 E-value: 3.26e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 1 MAGTVIEWYEFFIYGTAAALVfSVTFFPnGGNPLDAVLAAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGV 80
Cdd:PRK15075 21 TSGNFLEMFDFFLFGFYATAI-AKTFFP-AGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 81 ATFLMGCLPDFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNF 160
Cdd:PRK15075 99 GTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 161 LLSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKealksqEENSHASTG--LRTVITQYPKQLA-----VATAV 233
Cdd:PRK15075 179 WLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFL------ARKHRPSMReiFRSLAANWRIVLAgmlmvAMTTV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 234 rigenaMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWA-PFYFPLL 312
Cdd:PRK15075 253 ------SFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILTAyPALSWLV 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505212428 313 NTGSFIIILfAVIFGLvvqSFMYGP-EGALFG---ELFPTRARYAGVSAAYQLGSILGGSLAPIIAVFL 377
Cdd:PRK15075 327 AAPSFARML-AVELWL---SFLYGSyNGAMVValtEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWL 391
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
54-377 |
3.43e-37 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 139.74 E-value: 3.43e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 54 GGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAVLLVGEHSPPEQR 133
Cdd:cd17371 50 GGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 134 GYWASYPQAAASVGNVLATIVllgsNFLLSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEALKSQEENSHAS 213
Cdd:cd17371 122 GKALGYVQSGWAVGWLLATLL----AALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 214 TGLRTVITQYPKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKT 293
Cdd:cd17371 198 SLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNN 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 294 YLIGGVLALVWAPFYFPL-LNTGSFIIILFAVIFGLVVqsfMYGPEGALFGELFPTRARYAGVSAAYQLGSIlGGSLAPI 372
Cdd:cd17371 278 FALFALGSAISILLYFFLpLSPTLILILGFPLGFFASG---PFSGMGAYLTELFPTAVRATAQGFCYNVGRI-IGALFPF 353
|
....*
gi 505212428 373 IAVFL 377
Cdd:cd17371 354 LVGFL 358
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
6-420 |
2.59e-27 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 113.52 E-value: 2.59e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 6 IEWYEFFIYGTAAALVFSVTFFP----NGGNPLDAVLAAFLTyAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVA 81
Cdd:pfam00083 11 LFGYDTGVIGAFLTLIDFFKNFGlsksVSSLAALSVLSGLIV-SIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 82 TFLMGCLPdfsvwGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNFL 161
Cdd:pfam00083 90 AVLQGAAK-----GKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 162 LSEeaflaWGWRIAFWLS---AVVVFIG----------YYIRKKVEDA------------------PIFKEALKSQEENS 210
Cdd:pfam00083 165 SNS-----DGWRIPLGLQlvpALLLIIGllflpesprwLVEKGRLEEArevlaklrgvpdvdreldEIKDSLEAGQEAEK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 211 HASTGLRTVITqYPKQLAVATAVRIGENAMYYLIIAFTLTylTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGR 290
Cdd:pfam00083 240 ASWKELFSTKT-RRQRLLIGVMLQIFQQLTGINAIFYYST--TIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 291 RKTYLIGG----VLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALF---GELFPTRARYAGVSAAYQ--- 360
Cdd:pfam00083 317 RPLLLLGAagmaICFVILGIVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWvivSELFPLSVRSKAMALATAanw 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 361 LGSILGGSLAPIIAVFLWNTFDSWipiaIYLFtLLAFSIFSMVYGVKETSGTLLEDVDEE 420
Cdd:pfam00083 397 LANFLIGFLFPIITDAIGLGYTFF----IFAG-LLVLFIIFVFFFVPETKGRTLEEIDEL 451
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-409 |
4.90e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 111.12 E-value: 4.90e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 39 AAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFsvwgyaapIALAALRFIQGFAVGGEWG 118
Cdd:COG2271 46 QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 119 GAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGsnfllseeAFLAWGWRIAFWLSAVVVFIGyyirkkvedAPI 198
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW--------LLAAFGWRAAFLILGLPGLLL---------ALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 199 fkealksqeenshastglrtvitqypkQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSM 278
Cdd:COG2271 181 ---------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 279 IFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFmYGPEGALFGELFPTRARYAGVSAA 358
Cdd:COG2271 234 LLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA-FGLLWALAAELFPKKARGTASGLV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 505212428 359 YqLGSILGGSLAPIIAVFLWNTFdSWIPIAIYLFTLLAFSIFSMVYGVKET 409
Cdd:COG2271 313 N-TFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLALLLLRET 361
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
42-370 |
1.06e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.98 E-value: 1.06e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAV 121
Cdd:COG2814 49 LVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--------LLAARFLQGLGAGALFPAAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 122 LLVGEHSPPEQRGYWASYPQAAASVGNVLATIVllgSNFLLSeeaflAWGWRIAFWLSAVVVFIGYYIRKKVedapifke 201
Cdd:COG2814 121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLL---GGLLAD-----LFGWRWVFLVNAVLALLALLLLLRL-------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 202 aLKSQEENSHASTGLRTVITQYPKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFG 281
Cdd:COG2814 185 -LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 282 GYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLvvqSFMYGPEGALFGELFPTRARyAGVSAAYQL 361
Cdd:COG2814 264 GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGF---GLLFPLLQALVAELAPPEAR-GRASGLYNS 339
|
....*....
gi 505212428 362 GSILGGSLA 370
Cdd:COG2814 340 AFFLGGPLA 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
41-403 |
1.74e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 104.58 E-value: 1.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 41 FLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGA 120
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--------LLLLGLLLGIGGGGSFAVG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 121 VLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGsnfllseeAFLAWGWRIAFWLSAVVVFI-GYYIRKKVEDAPIF 199
Cdd:COG2223 115 IALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPL--------LIAAFGWRNAFLILGILLLVvAVLAWLFLRDPPAG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 200 KEALKSQEENSHASTgLRTvitqypKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMI 279
Cdd:COG2223 187 AAAAAKASLRDQLEA-LRD------PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRP 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 280 FGGYLSDQIGRRKTYLIGGVLALVWA-PFYFPLLNTGSFIIILFAVIFGLvvqSFMYGPEGALFGELFPTRARYAGVSAA 358
Cdd:COG2223 260 LGGWLSDRIGGRRVLLIVFALMALGLlLLALALGSLWLFLVLFLLLGLAL---GGGNGAVFALVPDIFPTKNAGAVYGLV 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 505212428 359 YQLGSiLGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIFSMV 403
Cdd:COG2223 337 GAAGG-LGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL 380
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-284 |
1.02e-23 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 100.66 E-value: 1.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 1 MAGTVIEWYEFFIYGTAAALVFSVtffpNGGNPLDAVLAAfltyAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGV 80
Cdd:COG0477 20 ALGTFLEGLDFTIVNVALPSIAAD----LGASSAQLGWIV----SAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 81 ATFLMGCLPDfsvwgyaaPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVllgsNF 160
Cdd:COG0477 92 ASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL----GG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 161 LLSEeaflAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEALKSQEENSHASTGLRTVITQYPKQLAVATAVRIGENAM 240
Cdd:COG0477 160 LLVA----ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLA 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 505212428 241 YYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYL 284
Cdd:COG0477 236 GAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALL 279
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
42-404 |
4.76e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.96 E-value: 4.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAV 121
Cdd:cd17325 35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLLARFLQGLASAAVWPAAM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 122 LLVGEHSPPEQRGYWASYPQAAASVGNVLATIVllgSNFLLSeeaflAWGWRIAFWLSAVVVFIGYYIRkkvedAPIFKE 201
Cdd:cd17325 107 ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL---GGLLAD-----ALGYRAPFLVCAALALLALVLA-----LLLLPE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 202 ALKSQEENSHASTGLRTVITQ--YPKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMI 279
Cdd:cd17325 174 PRPPPNKRAVSAARLRSGLRLllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 280 FGGYLSDQIGRRKTYLIGgvlALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELFPTRAR---YAGVS 356
Cdd:cd17325 254 PAGKLSDRIGRKPLILIG---LLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRgtaMGLFN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 505212428 357 AAYQLGSILGgslaPIIAVFLWNTFDSWIPIAIYLFTLLAFSIFSMVY 404
Cdd:cd17325 331 TAFSLGMVLG----PLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
34-373 |
3.00e-20 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 92.84 E-value: 3.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 34 LDAVLAAFLTYAiGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAV 113
Cdd:PRK03893 52 LTTVQAASLISA-AFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWT--------LFIARLVIGMGM 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 114 GGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVllgsnfllSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKV 193
Cdd:PRK03893 123 AGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQV--------YSLVVPVWGWRALFFIGILPIIFALWLRKNL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 194 EDAPIFKEALKSQEENSHASTGLRTVITQYPKQLAVATAVR------IGENAMYYLIIAFTL------------------ 249
Cdd:PRK03893 195 PEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILLTLAAAAalwfcfAGNLQNAAIVAVLGLlcaaifisfmvqssgkrw 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 250 -------------------------TYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVw 304
Cdd:PRK03893 275 ptgvmlmvvvlfaflyswpiqallpTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQL- 353
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505212428 305 apFYFPL-LNTGSFIIILFAVIFGLvvQSFMYGPEGAL---FGELFPTRARYAGVSAAYQLGSiLGGSLAPII 373
Cdd:PRK03893 354 --LIIPVfAIGGANVWVLGLLLFFQ--QMLGQGISGLLpklIGGYFDTEQRAAGLGFTYNVGA-LGGALAPIL 421
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
34-377 |
1.54e-19 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 90.11 E-value: 1.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 34 LDAVLAAFLtYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFsvwgyaapIALAALRFIQGFAV 113
Cdd:TIGR00895 49 LDPVQLGFL-FSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV--------TQLLILRFLAGLGL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 114 GGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVllgSNFLLSeeaflAWGWRIAFWLSAVVVF--------- 184
Cdd:TIGR00895 120 GGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFL---AGWLIP-----VFGWRSLFYVGGIAPLllllllmrf 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 185 ----IGYYIRKKVE---------DAPIFKEALKSQEENSHASTGLRTVIT-----QYPKQLAVATAVRIGENAMYYLIIA 246
Cdd:TIGR00895 192 lpesIDFLVSKRPEtvrrivnaiAPQMQAEAQSALPEQKSTQGTKRSVFKalfqgKTARITVLLWLLYFMLLVGVYFLTN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 247 FtLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKT---YLIGGVLALVWAPFYFpllntGSFIIILFA 323
Cdd:TIGR00895 272 W-LPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTallLLLGAVFAVLVGSTLF-----SPTLLLLLG 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 505212428 324 VIFGLVVQSfMYGPEGALFGELFPTRARYAGVSAAYQLGSiLGGSLAPIIAVFL 377
Cdd:TIGR00895 346 AIAGFFVNG-GQSGLYALMALFYPTAIRATGVGWAIGIGR-LGAIIGPILAGYL 397
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
42-371 |
2.50e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.93 E-value: 2.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSvwgyaapiALAALRFIQGFAVGGEWGGAV 121
Cdd:pfam07690 36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--------LLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 122 LLVGEHSPPEQRGYWASYPQAAASVGNVLATIVllgSNFLLSeeaflAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKE 201
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLL---GGLLAS-----LFGWRAAFLILAILSLLAAVLLLLPRPPPESKR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 202 ALKSQEENSHASTGLRTVITQYPKQLAVATavrIGENAMYYLIIAFTLTYLTIFDaMTSQDVLLIMFIANIVQFFSMIFG 281
Cdd:pfam07690 180 PKPAEEARLSLIVAWKALLRDPVLWLLLAL---LLFGFAFFGLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 282 GYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELFPTRARyAGVSAAYQL 361
Cdd:pfam07690 256 GRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER-GTASGLYNT 334
|
330
....*....|
gi 505212428 362 GSILGGSLAP 371
Cdd:pfam07690 335 AGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
53-400 |
2.54e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 86.06 E-value: 2.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFsvwgyaapIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQ 132
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--------ALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 133 RGYWASYPQAAASVGNVLAtiVLLGSnfLLSEeaflAWGWRIAFWLSAVVVFIGyyirkkvedAPIFKEALKSQEENSHA 212
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLG--RPLGG--LLGQ----LLGWRAAFLAIAVLALLA---------ALLLWRLLPSLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 213 STGLRTVITQYPKQLAVATAVRIG--ENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGR 290
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRLAYLITflLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 291 RKTYLIGGVLALVWAPfyFPLLNTGSFIIILFAVIFGLVVQSfMYGPEGALFGELFP-TRARYAGV-SAAYQLGSILGGS 368
Cdd:cd17324 264 RALLIALLLLAAALLL--LTLLGPSPLLLLVGLVLWGLGFFA-AHSALQTRVLRLAPeARGLASSLyLAAYNLGGALGAA 340
|
330 340 350
....*....|....*....|....*....|..
gi 505212428 369 LApiiAVFLWNTFDSWIPIAIYLFTLLAFSIF 400
Cdd:cd17324 341 LG---GLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
8-381 |
3.75e-17 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 83.05 E-value: 3.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 8 WYEFFIYGTAAALVFSVTFFPNGGNPLDAVLAAFLTYAiGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGC 87
Cdd:PRK12307 24 WLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATA-AFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 88 LPDFsvwgyaapIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLlgsnfllsEEAF 167
Cdd:PRK12307 103 ASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFM--------PSFA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 168 LAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEAL---KSQEENSHASTGLRTVITQYPK-QLAVATAVRIGENAMY-- 241
Cdd:PRK12307 167 EAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKlsgKGKHSQSAWSVFSLSMKGLFNRaQFPLTLCVFIVLFSIFga 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 242 -YLIIAFTLTYLTiFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVW--APFYFPLLNTGSFI 318
Cdd:PRK12307 247 nWPIFGLLPTYLA-GEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFifPLFRIPQDNYLLLG 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505212428 319 IILFAVIF-----GLVVQSFMYgpegalfgELFPTRARYAGVSAAYQLGSIlGGSLAPIIAVFLWNTF 381
Cdd:PRK12307 326 ACLFGLMAtnvgvGGLVPKFLY--------DYFPLEVRGLGTGLIYNLAAT-SGTFNSMAATWLGITM 384
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
42-400 |
4.12e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 82.47 E-value: 4.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAV 121
Cdd:cd06174 35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL--------LLLGRFLLGLGSGLIDPAVL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 122 LLVGEHSPPEQRGYWASYPQAAASVGNVLAtiVLLGSNFLLseeaFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKE 201
Cdd:cd06174 107 ALIADLFPERERGRALGLLQAFGSVGGILG--PLLGGILAS----SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 202 ALKSQEENSHASTGLRTVITQYPKQLAVATAVRIGeNAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFG 281
Cdd:cd06174 181 RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLV-NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 282 GYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFglVVQSFMYGPEGALFGELFPTRARyAGVSAAYQL 361
Cdd:cd06174 260 GLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG--FGLGGLLPLSFALIAELFPPEIR-GTAFGLLNT 336
|
330 340 350
....*....|....*....|....*....|....*....
gi 505212428 362 GSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIF 400
Cdd:cd06174 337 FGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
20-403 |
4.66e-16 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 79.63 E-value: 4.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 20 LVFSVTFFPNGGNPLDAVLAafLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFsvWGYAAP 99
Cdd:cd17364 23 KILGRLYYGGKGSLPSGVSG--LVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGS--TPLGVM 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 100 IALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLL------GSNFLLSEEAFLAWGWR 173
Cdd:cd17364 99 GWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLilsaifEHPLPAGTYHHADLVWR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 174 IAFWLSAVVVFIGYYIRKKVEDApifkealksqeenshASTGLRTVITQYPKQLAVATavrigenamyylIIAftlTYLT 253
Cdd:cd17364 179 IVLGLGAIPALSVLYFRKHLLGT---------------AGTWFLLDIAFYGQNLFQST------------IIS---AIGF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 254 IFDAMTSQDVLLIMFIANIVQFFSMI----FGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLV 329
Cdd:cd17364 229 SKTMNAYQELFNIAVGQLIIALAGTVpgywFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKISTIGFFVLYGLT 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505212428 330 VQSFMYGPEGALF---GELFPTRAR--YAGVSAAyqlgsilGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIFSMV 403
Cdd:cd17364 309 FFFSNFGPNTTTFivpAEVFPARVRstCHGISAA-------SGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGII 380
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
42-416 |
1.27e-14 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 75.82 E-value: 1.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAV 121
Cdd:TIGR00898 131 LTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTV--------FLVFRLLVGMGIGGIWVQAV 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 122 LLVGEHSPPEQRGYWASYPQAAASVGNVLativllgsnfllseEAFLAW---GWR-IAFWLSA-VVVFIGYY-------- 188
Cdd:TIGR00898 203 VLNTEFLPKKQRAIVGTLIQVFFSLGLVL--------------LPLVAYfipDWRwLQLAVSLpTFLFFLLSwfvpespr 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 189 ---IRKKVEDA---------------------PIFKEALKSQEENSHASTGLRTvitqypKQLAVATAVRIgenaMYYLI 244
Cdd:TIGR00898 269 wliSQGRIEEAlkilqriakingkklpaevlsLSLEKDLSSSKKQYSFLDLFRT------PNLRKTTLCLM----MLWFT 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 245 IAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKT----YLIGGV--LALVWAPFYFPLLNTG--- 315
Cdd:TIGR00898 339 TAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTmaasLLLAGValLLLLFVPVDLYFLRTAlav 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 316 ---SFIIILFAVIfglvvqsFMYGPegalfgELFPTRARYAGVSAAYQLgSILGGSLAPIIAVFLwnTFDSWIPIAIYLF 392
Cdd:TIGR00898 419 lgkFGITSAFQMV-------YLYTA------ELYPTVVRNLGVGVCSTM-ARVGSIISPFLVYLG--EKWLFLPLVLFGG 482
|
410 420
....*....|....*....|....
gi 505212428 393 TLLAFSIFSMvyGVKETSGTLLED 416
Cdd:TIGR00898 483 LALLAGILTL--FLPETKGVPLPE 504
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
53-358 |
2.42e-14 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 74.14 E-value: 2.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAVLLVGEHSPPEQ 132
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTI--------FIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 133 RGYWASYPQAAASVGNVLATIVllgsNFLLSEEAFLAW----GWRIAFWLS---AVVVFIGYYIrkkVEDAPIFKealks 205
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIV----NYLIANAGGADWlgaeGWRWMLGLEaipAILFLLGMLF---IPESPRWL----- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 206 qeenshASTGLRTVITQYpkQLAVATAVrIGENA-MYYLIIAFTLTyltifdAMTSQDVLLIMFIANIVQFFSMIFGGYL 284
Cdd:cd17359 191 ------VSKGKPILIIGI--GLAIFQQF-VGINViFYYGPEIFQNA------GFSENAALLQTIGIGVVNVIFTIIAILL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 285 SDQIGRRKTYLIGGV-----LALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGP-EGALFGELFPTRARYAGVSAA 358
Cdd:cd17359 256 VDKVGRKPLLLIGSIgmaisLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPvTWVLLSEIFPNRIRGLAMGIA 335
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-403 |
3.76e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 70.29 E-value: 3.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 41 FLTYAIGFIarpLGGFvfgqLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFsvwgyaapIALAALRFIQGFAVGGEWGGA 120
Cdd:cd17319 48 FLGYALFQV---PGGW----LLDRFGARKVLAVSMLLWSLFTALTGFATSL--------TSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 121 VLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVllgSNFLLseeafLAWGWRIAFWLSAVVVFIgyyirkkvedapifk 200
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPL---SGWLL-----LLFGWRWAFIIEGLLGLL--------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 201 ealksqeenshastgLRTVITQYPKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIF 280
Cdd:cd17319 170 ---------------LAVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 281 GGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELFPtRARYAGVSAAYQ 360
Cdd:cd17319 235 GGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLP-GEAAATAGGLIN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 505212428 361 LGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIFSMV 403
Cdd:cd17319 314 SGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
2-417 |
7.46e-13 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 70.06 E-value: 7.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 2 AGTVIEWYEFFIYGTAAALVFSVTFFPNGGNPLDAVLAAfLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVA 81
Cdd:TIGR00879 36 GGLMFGYDTGVIGGALALPAFEFKFTSANSDSYSSSLWG-LVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 82 TFLMGCLPD-FSVWgyaapiALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNF 160
Cdd:TIGR00879 115 AILMGLAAFaLSVE------MLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 161 LLSEEaflawGWRIAF---WLSAVVVFIG----------YYIRKKVEDApifKEAL-KSQEENSHASTGLRTVITQYPKQ 226
Cdd:TIGR00879 189 LNNTL-----GWRIPLglqLIPAGLLFLGlfflpesprwLVGKGRVEEA---RKSLaRLRGTSGEDKELLDELELIDIKR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 227 LAVATAVRIGENAMYYL------------IIAFT--------LTY--LTIFD--AMTSQDVLLIMFIANIVQFFSMIFGG 282
Cdd:TIGR00879 261 SIEKRSVQPSWGSLFSStrrirrrlflgvVLQWFqqftginaIMYysPTIFEnaGVSTDHAFLVSIIVGAVNFAFTFVAI 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 283 YLSDQIGRRKTYLIGGV---LALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGA-----LFGELFPTRARYAG 354
Cdd:TIGR00879 341 FLVDRFGRRPLLLIGAAgmaICLFVLGILGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGpvpwvIVSEIFPLSLRPKG 420
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505212428 355 VS---AAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIFsmvygVKETSGTLLEDV 417
Cdd:TIGR00879 421 ISiavAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFF-----LPETKGRTLEEI 481
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
46-370 |
1.21e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 68.77 E-value: 1.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 46 IGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDfsvwgyaaPIALAALRFIQGFAVGGEWGGAVLLVG 125
Cdd:cd17365 42 AALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--------VLQLALLRFLTGLGLGAAMPNAITLVS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 126 EHSPPEQRGYWASYPQAAASVGNVLATIVllgSNFLLSeeaflAWGWRIAFWLSAVVVFIGyyirkkvedAPIFKEALKs 205
Cdd:cd17365 114 EYAPARRRSLAVTLMFCGYPLGAALGGFL---AAALIP-----AFGWRSVFLLGGVPPLIL---------LPLLRGTLL- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 206 qeenshastglrtvitqypkqLAVATavrigenAMYYLIIAFTLTYL-TIFDA--MTSQDVLLIMFIANIVQFFSMIFGG 282
Cdd:cd17365 176 ---------------------LWVTF-------FMGLLLVYLLNSWLpKLMVEagYSLSQALTITLLLNIGGVIGSLLLG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 283 YLSDQIGRRKT----YLIGGVLALVWAPFYFPLlnTGSFIIILFAVIFGLVVQSFMYgpegALFGELFPTRARYAGVSAA 358
Cdd:cd17365 228 WLADRFGPKRVlalfFALGAVSLALLGVSPASL--VLLYVLVFLAGACVNGAQVGLY----ALAARFYPTEVRATGVGWA 301
|
330
....*....|....*
gi 505212428 359 Y---QLGSILGGSLA 370
Cdd:cd17365 302 LgvgRLGAILGPLLG 316
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
38-378 |
1.27e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 69.16 E-value: 1.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 38 LAAFLTYAIGFIARPLGGFVFGQLGDRFGRKK-MLQVSLIMIGVATFLMGCLPDFSVWGYAapIALAALRFIQGFAVGGE 116
Cdd:COG2211 50 LILLVARLWDAITDPLIGALSDRTRTRWGRRRpWILIGAIPLALSFVLLFTAPDLSPTGKL--IYALVTYLLLGLAYTLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 117 WGGAVLLVGEHSP-PEQRGYWASYPQAAASVGNVLATIVLLGSNFLLSEEAflAWGWRIAFWLSAVVVFIGYYIrkkved 195
Cdd:COG2211 128 NIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLL------ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 196 aPIF--KEALKSQEENSHASTGLRTVITqyPKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIV 273
Cdd:COG2211 200 -TFFgtKERPVPEEEKVSLKESLKALLK--NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 274 QFFSMIFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPeGALFGELFP-----T 348
Cdd:COG2211 277 ALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLP-WAMLADVVDydewkT 355
|
330 340 350
....*....|....*....|....*....|.
gi 505212428 349 RARYAGV-SAAYQLGSILGGSLAPIIAVFLW 378
Cdd:COG2211 356 GRRREGLyFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
42-397 |
1.70e-12 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 67.99 E-value: 1.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVWgyaapialAALRFIQGFAVGGEWGGAV 121
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELF--------LVLRFLVGVTSAGIFTVGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 122 LLVGEHSPPEQRGYWASYPQAAASVGNVLATIVllgsnfllseeAFLAWGWR----IAFWLSAVVVFIGYYIRKkvedap 197
Cdd:cd17317 101 VLGMEIVGPKYRSFVGILFGLFWALGYMLLALL-----------AYLIRDWRwlqlAISLPGLLFLLLLWWLPR------ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 198 ifkealksqeenshastglRTVItqypkqlavatavrigenaMYYLIIAFTLTYLTIFDAMTSQ--DVLLIMFIANIVQF 275
Cdd:cd17317 164 -------------------RTII-------------------VGLIWFVTSLVYYGLSLNSSNLggNLYLNFFLSGLVEI 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 276 FSMIFGGYLSDQIGRRKTY---LIGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYgpegALFGELFPTRARY 352
Cdd:cd17317 206 PAYFLALLLLDRLGRRWTLsgsLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIY----LYTAELYPTVVRN 281
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 505212428 353 AGVSaayqLGSILGGsLAPIIAVFLWNTFDSWIPIAIYLFTLLAF 397
Cdd:cd17317 282 TGVG----LCSTVAR-VGAILAPFIVLLGKIGPLLPLIIFGVLAL 321
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
44-403 |
4.99e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 66.81 E-value: 4.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 44 YAIGFIarpLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVWgyaapialAALRFIQGFAVGGEWGGAVLL 123
Cdd:cd17477 40 YYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVW--------FLLRFVMGIGLAGLFVVSESW 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 124 VGEHSPPEQRGYWASYPQAAASVGNVLATIVLLgsnfLLSEEAFLAwgwriaFWLSAVVVFIGYyirkkvedAPIFKEAL 203
Cdd:cd17477 109 LNALATNENRGRVLGLYSTVLGLGFALGPLLLA----LVGTAGALP------FLIAAVLLLLAL--------VPLLLTRR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 204 KSQEENSHASTGLRTVITQYPKQLAVATAVRIGENAMYYLIIAFTLTyltifDAMTSQDVLLIMFIANIVQFFSMIFGGY 283
Cdd:cd17477 171 AAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLR-----LGLSVAQAALLLAAFVLGGLLLQWPLGW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 284 LSDQIGRRKTYLIGGVLALVwAPFYFPLLNTGSFIIILFAVIFGLVVQSfMYGPEGALFGELFPtRARYAGVSAAYQLGS 363
Cdd:cd17477 246 LADRFDRRRVLLGCALLGAL-AALLLPLVPGLPLALLVLLFLWGGAAGP-LYTLALALAGDRLP-GDELVAANAALLLLY 322
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 505212428 364 ILGGSLAPIIAVFLWNTFDswiPIAIYLFTLLAFSIFSMV 403
Cdd:cd17477 323 GLGSVIGPLLAGALMDAFG---PHGLFLFLAAVALLFLLF 359
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
17-358 |
1.11e-11 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 66.06 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 17 AAALVFSVTFFPNGGNPL--DAVLAAFLTYAIgfiarpLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVw 94
Cdd:cd17315 17 NGALLYIAKDLGFGLSTSlqGLVVSSLLLGAA------IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 95 gyaapiaLAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLAtiVLLGSNFLLSEEaflaWGWRI 174
Cdd:cd17315 90 -------LIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLA--YLLGLALSLSPP----GWWRL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 175 AFWLSAVVVFIGYYIRKKVEDAPIFkealksqeenshaSTGLRTVITQypkQLAVATAVrigenaMYYLIiaftltylTI 254
Cdd:cd17315 157 MFALAAVPALLQLLLMFFLPESRAL-------------LVGVGLQLLQ---QLTGINAV------MYYAP--------TI 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 255 F-DAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGV-----LALVWAPFYFPLLNTGSFIIILFAVIFGL 328
Cdd:cd17315 207 FkSAGGGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAgmaasLLLLAIAFLLPALAKAAGWLALLGILLYI 286
|
330 340 350
....*....|....*....|....*....|.
gi 505212428 329 VVQSFMYGPEGALFG-ELFPTRARYAGVSAA 358
Cdd:cd17315 287 AAFAMGAGPVPWLLLsEIFPLRIRGKGMAIA 317
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
42-420 |
2.34e-11 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 65.52 E-value: 2.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVWGYAAPIALaaLRFIQGFAVGGEWGGAV 121
Cdd:TIGR00887 60 AVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMATLCF--WRFWLGVGIGGDYPLSA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 122 LLVGEHSPPEQRGYWASYPQAAAS----VGNVLATIVLLGSNFLLSEEAFLA-----------WGWRIAFWLSAVVVFIG 186
Cdd:TIGR00887 138 IITSEFATKKWRGAMMAAVFAMQGfgilAGAIVALIVLAGFKHSLEAAADEAsctgscvpavdYMWRILIGFGAVPALLA 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 187 YYIRKKVEDAPIF--------------------KEALKSQEENSHASTGLRT-------VITQYPK----QLAVATAVri 235
Cdd:TIGR00887 218 LYFRLTIPETPRYtadvakdveqaasdmsavlqVKIEAEPDEVEKASTAVEVpkaswsdFFTHFFKwrhgKHLLGTAG-- 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 236 genAMYYLIIAF------------TLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGY-----LSDQIGRRKTYLIG- 297
Cdd:TIGR00887 296 ---SWFLLDIAFygvnlnqkvilsAIGYSPPAATNNAYEELYKTAVGNLIIALAGTVPGYwvtvfLVDIIGRKPIQLMGf 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 298 ---GVLALVWAPFYFPLLNTGSFIIILFAVIFglvvqsFMYGPEGALF---GELFPTRARYA--GVSAAY-QLGSILG-- 366
Cdd:TIGR00887 373 filTVLFFVLGFAYNHLSTHGFLAIYVLAQFF------ANFGPNATTFivpGEVFPTRYRSTahGISAASgKAGAIIGqf 446
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 505212428 367 --GSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIFSMVYGVKETSGTLLEDVDEE 420
Cdd:TIGR00887 447 gfLYLAQHGDPTKGYPTGIWMGHVLEIFALFMFLGILFTLLIPETKGKSLEELSGE 502
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
42-411 |
5.89e-11 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 64.20 E-value: 5.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGclpdFSVWGYAaPIALAALRFIQGFAVGGEWGGAV 121
Cdd:cd17357 53 LIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMF----LSKSAKS-PELLIFGRFLVGIACGLSTGFVP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 122 LLVGEHSPPEQRGYWASYPQAAASVGNVLATivLLGSNFLLSEEAflawGWRIAFWLSAVVVFIG--------------- 186
Cdd:cd17357 128 MYLQEISPSELRGALGSLTQIGVTLGILLGQ--VFGLPSVLGTET----LWPYLLFFPGIPALLQlaalpffpespkfll 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 187 --------------YYIRKKVEDAPIFKEALKSQEENSHASTG-LRTVIT--QYPKQLAVATAVRIGEN-AMYYLIIAFT 248
Cdd:cd17357 202 iskgdeeeaekslkFLRGIEDDVDQELEEIKKESEQMGDQKQVsLMQLLRdpSLRLPLLLVLVVSASQQfSGINAIFFYS 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 249 LTYLTifDA-MTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGV------LALVWAPFYFPLLNTGSFIIIL 321
Cdd:cd17357 282 TFIFE--NAgFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSvcavalLLMSVFLFLSEQNSWMSYGCIV 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 322 FAVIFGLVVQsFMYGPEGALFG-ELFPTRARyagvSAAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIF 400
Cdd:cd17357 360 AIFLFIFFFA-IGLGPIPWFIGaELFPQAPR----SAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFL 434
|
410
....*....|..
gi 505212428 401 SMVY-GVKETSG 411
Cdd:cd17357 435 LYLYrYLPETKG 446
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
56-403 |
1.84e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.20 E-value: 1.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 56 FVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGY 135
Cdd:cd17474 52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL--------LLAGRALQGIGAAGLGPLALTLIGDLFEGGERAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 136 WASYPQAAASVGNVLATIV--LLGsnfllseeaflAWGWRIAFWLSAVVVFIGYYIRKkvedapIFKEALKSQEENSHAS 213
Cdd:cd17474 124 AMGLYEAALGLGIAVGPLLggLLA-----------AISWRYPFFLLAALIPVAFLAIL------FLLPEPKEKAKSSSAT 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 214 TGLRTVITQYPKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANI-VQFFSMIFGGYLSDQIGRRK 292
Cdd:cd17474 187 KLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVlLALGSLFVGRLLKKRFGARR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 293 TYLIGGVLALVWAPFYFPLLNTGSFII--ILFAVIFGLVVQSFMygpegALFGELFPTRARyAGVSAAYQLGSILGGSLA 370
Cdd:cd17474 267 ILVIGLLLYALSLLLLGFVPSLALLLIaiVLFGLGLGLNLPLLT-----TLVTELAPEEER-GTASSLYNFVRFLGQAVG 340
|
330 340 350
....*....|....*....|....*....|....
gi 505212428 371 PIIAVFLWNTFD-SWIPIAIYLFTLLAFSIFSMV 403
Cdd:cd17474 341 PLLFGLLLEIFGlSAPFLVGAAIALAAAVLLALL 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-405 |
1.89e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.20 E-value: 1.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 34 LDAVLAAFLTyAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSvwgyaapiALAALRFIQGFAV 113
Cdd:COG2807 50 LSATQAGLLT-TLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVA--------LLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 114 GGewGGAVL--LVGEHSPpEQRGYWASYPQAAASVGNVLATivllgsnfLLSEEAFLAWGWRIAFWLSAVVVFIGyyirk 191
Cdd:COG2807 121 AV--GNVLLpgLIKRWFP-DRVGLMTGLYTAAMGLGAALAA--------GLTVPLAAALGWRGALAVWALLALLA----- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 192 kvedAPIFKEALKSQEENSHASTGLRTVITQYPKQLAVATAVRIG-ENAMYYLIIAFTLTYLTifDA-MTSQDVLLIMFI 269
Cdd:COG2807 185 ----LLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGlQSLLYYAVVAWLPPILR--DAgLSAATAGLLLSL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 270 ANIVQFFSMIFGGYLSDQIGRRKTYLIggVLALVWAPFYFPLLNTGSFIIILFAVIFGLVvQSFMYGPEGALFGELFPTR 349
Cdd:COG2807 259 FQLAGIPGSLLVPLLADRLGDRRPLLL--LLGLLGLAGLLGLLLAPGSLPWLWAVLLGLG-QGGLFPLALTLIGLRARTP 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 505212428 350 ARYAGVSAAYQLGSILGGSLAPIIAVFLWNTFDSW-IPIAIYLFTLLAFSIFSMVYG 405
Cdd:COG2807 336 AEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWtAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
53-406 |
8.80e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.28 E-value: 8.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFsvwgyaapIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQ 132
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL--------YALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 133 RGYWASYPQAAASVGNVLATIVllgSNFLLSeeaflaWGWRIAFW--LSAVVVFIGYYIRkkvedapIFKEALKSQEENS 210
Cdd:cd17473 122 RAKMLGLQSAAMSLGGVVFLLL---GGALAE------IGWRAPFLvyLLALPVLILVLLF-------LPEPARKSKSAAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 211 HASTGLRTVItqyPKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGR 290
Cdd:cd17473 186 PGAATAAALP---WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 291 RKTYLIG------GVLALVWAPFYFPLLntgsFIIILFAVIFGLVVQSFMygpegALFGELFPTRARyAGVSAAYQLGSI 364
Cdd:cd17473 263 RRLLAIGfalmalGFLLLALASGLWVVL----LGAILAGLGFGLLLPTLN-----SWAMSLVPPELR-GRAMGIVTSAFF 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 505212428 365 LGGSLAPIIAVFLWNTFDSwipiaiYLFTLLAFSIFSMVYGV 406
Cdd:cd17473 333 LGQFLSPLVLGPLVNLTGG------LSGAFLILGVLALVLAI 368
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
57-377 |
6.53e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.57 E-value: 6.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 57 VFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAVLLVGEHSPPEQR--- 133
Cdd:cd17321 50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAF--------LIAARALQGIGAAAIMPASLALIAATFPGERRgra 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 134 -GYWASYPQAAASVGNVLATIVLlgsnfllseeafLAWGWRIAFWLSAVVVFIGYYIrkkvedAPIFkealksqeensha 212
Cdd:cd17321 122 lGLWGAVVGIGAALGPLLGGLLL------------ELFGWRWIFLINVPIGLVALLL------ARTF------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 213 stglrtvitqypkqlAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRK 292
Cdd:cd17321 171 ---------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 293 TYLIGGVL-ALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELFPTRARYAG--VSAAYQLGSILGGSL 369
Cdd:cd17321 236 VLVAGLLLtAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASgiLNTARQLGGALGVAL 315
|
....*...
gi 505212428 370 APIIAVFL 377
Cdd:cd17321 316 LGALLTAG 323
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-394 |
8.23e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.22 E-value: 8.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 30 GGNPLDAVLAAFLTYAIGFIARPLGGfvfgQLGDRFGRKKMLQVSLIMIGVATFLMgcLPDFSVWGyaapiaLAALRFIQ 109
Cdd:cd17489 27 GGSEAVAGLVVGLFTLAALLARPFAG----RLLDRFGRKRLLLIGLLIFALATLLY--LLATSVAL------LLVLRLIH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 110 GFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVllgSNFLLSeeaflAWGWRIAFWLSAVVVFIGYYI 189
Cdd:cd17489 95 GIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL---GLFLYQ-----HLGFAVLFIVAAVLALLALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 190 rkkvedAPIFKEALKSQEENSHASTGLRTVITQYpkqlavatAVRIGENAMYYLIIAF--TLTYLTIFDAMTSQDVLLIM 267
Cdd:cd17489 167 ------VFLVKDPPPVAAEEAEAGTRAFRRLVEK--------KVLPPALILFLASIAYgaISTFLPLYAAERGISNAGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 268 FIAN-IVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVwapFYFPLLNTGSFI-IILFAVIFGLvVQSFMYGPEGALFGEL 345
Cdd:cd17489 233 FTVYaIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL---GLLLLSFAGSPWmLLLAAVLYGL-GFGLLFPALQALAVDL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 505212428 346 FPTRAR-------YAGVSAAYQLGSILGGSLAPII---AVFLWNTFDSWIPIAIYLFTL 394
Cdd:cd17489 309 VPPHRRgaangtfFIFFDLGIGLGGLLLGLVAELFgyrAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
57-403 |
1.67e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.48 E-value: 1.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 57 VFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFsvwgyaapIALAALRFIQGFavgGEWGGAVL---LVGEHSPPEQR 133
Cdd:cd17328 53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--------WQLLLFRALVGI---GEASYSPIaptIIADLFPKEKR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 134 GYWASYPQAAASVGNVLATIVllGSNFllseeAFLAWGWRIAFWLSAVV-VFIGYYIRKKVEDAP--IFKEALKSQEENS 210
Cdd:cd17328 122 TRALGVFYFAIPLGSGLGYVV--GGLV-----AQATGGWRWAFRVTGVLgVLLAILLLLFVREPPrgAAEGGVMAKSTAT 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 211 HASTGLRTVITQYPKQLAVA--TAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQI 288
Cdd:cd17328 195 SFLADLKALAKNPSFILSTLgfTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 289 GRR--KTY-LIGGVLALVWAPFYFPLLNTGSFIIILfAVIFGLVVQSFMY---GPEGALFGELFPTRARYAGVSAAYQLG 362
Cdd:cd17328 275 RRKtpRADpLVCAVGLLAAAPFLFLALVLALSNLLL-AWVLLFLGEFLLSlnwAPVFAILLYVVIPTRRSTASAIQILLS 353
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 505212428 363 SILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIFSMV 403
Cdd:cd17328 354 HLLGDAGSPYLIGLISDLLRQNKDSPLAEAASLQYALLLCS 394
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
56-400 |
1.70e-08 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 56.09 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 56 FVFGQLGDRFGRKKMLQVSLIMIGVATFLMgclPDFSVWGYAApiaLAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRGY 135
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITALLTLLT---PLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 136 WASYPQAAASVGNVlatIVLLGSNFLLSeeaflAWGWRIAFWLS---AVVVFIGYYIrkkvedapifkealksqeensha 212
Cdd:cd17318 148 LTSIAYSGSQFGTV---IAMPLSGFLCE-----SLGWPSIFYIFgglGLLWCLLWFF----------------------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 213 stglrtvitqYPKQLAVATAVRIGENAMYYLIIAFTLTYLtifdamtsQDVLLIMFIAN--------IVQFFSMIFGGYL 284
Cdd:cd17318 197 ----------LVLPVWAIVVAHFGHNWGFYTLLTELPTYM--------SDVLHFNIKSNgflsslpyLAMWICSIVGGYL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 285 SDQIGRRKTY-------------LIGGVLALVWAPFyfpllNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELFPtraR 351
Cdd:cd17318 259 ADWLRSRGILstttvrklftsigFLGPGVFLIALGY-----LGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAP---N 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 505212428 352 YAG-VSAAYQLGSILGGSLAPIIAVFL---WNTFDSW-----IPIAIYLFTLLAFSIF 400
Cdd:cd17318 331 YAGtLMGITNTAATIAGIISPLIVGAIvknDQTIGQWrivffISAAIYILGAIFYLIF 388
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
176-392 |
5.00e-08 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 54.81 E-value: 5.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 176 FWLSAVVVFIGYYIR-KKVEDAPIFKEALKSQEENSHASTGLRTVITQYPKqLAVATAVRIGENAMYYLIIAFTLTYLTI 254
Cdd:cd17337 159 LWLSLVFVALGGLIAlFLVRDRTGEQPLANPSEEPLKELLSGITILFRNPK-IAIGGIVRIINTLSQFGFPVFMPLYFTD 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 255 FDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTY-LIGGV------LALVWAPFYFPllnTGSFIIILFAVIFG 327
Cdd:cd17337 238 TGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVrWFGGVgcaistLLFYYVPQLFG---HNYWAALIAAILFG 314
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505212428 328 LVVQSFmyGPEGALFGELFPTRaRYAGVSaAYQLGSILGGSLAPIIAVFLWNTFDS----WIPIAIYLF 392
Cdd:cd17337 315 IGLAGF--VPLSALMPSLAPEH-KGAAMS-ILNLGAGLSNFVGPAIVTLFLGSFGAggvvWIFAGLYLL 379
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
53-419 |
5.23e-08 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 54.56 E-value: 5.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMlqvslIMIGVATFLMGCLPDFSVWGYAAPIALAalRFIQGFAVGGEWGGAVLLVGEHSPPEQ 132
Cdd:cd17356 60 FGALISSFLSDRIGRKKS-----IQIGCVIYIIGAIIQVAAIGKWYQLIVG--RIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 133 RGYWASYPQAAASVGNVLATIVLLGSNFLLSEEAF-LAWGWRIAFwlsAVVVFIGYYirkKVEDAPIFKealksqeensh 211
Cdd:cd17356 133 RGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQWrIPLGLQIVW---GLLLLIGMF---FLPESPRWL----------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 212 astgLRTVI---TQYPKQLavatavrIGENAMYYLIIaftltylTIFDA--MTSQDVLLIMFIANIVQFFSMIFGGYLSD 286
Cdd:cd17356 196 ----YRTILgimLQLFQQL-------TGINYFFYYGT-------TIFQStgLTGSSPLLTSIILYIVNFVSTIPGLFFVD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 287 QIGRRKTYLIGGVLALVWAPFYFPLLNTGSF---------------IIILFAVIFGLVVQSFmyGPEGALF-GELFPTRA 350
Cdd:cd17356 258 KFGRRTCLLIGAAGMSICLFIYAAVGVRYLIpnpqsgtsnksagngMIVFICLFIFSFATTW--GPIAWVYvAEVFPLRV 335
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505212428 351 RYAGVSAAyqlgsilggslapIIAVFLWNTFDSWI-PIAI--------YLFT-LLAFSIFSMVYGVKETSGTLLEDVDE 419
Cdd:cd17356 336 RSKGMALA-------------TAFNWLWNFLISFFtPFIIgsigfkyyYIFAgCNLLAFIVVFFFVPETKGLTLEEIDE 401
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
44-377 |
1.35e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.43 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 44 YAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPdfSVWGYAAPIALaalrfIQGFAVGGEWGGAVLL 123
Cdd:cd17355 44 FTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT--SLWQLYLLWGL-----LGGGGAGTLAAVAFAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 124 VGEHSPPEQRGYWASYPQAAASVGnvlATIVLLGSNFLLSeeaflAWGWRIAFWLSA-----VVVFIGYYIRKKVEDAPI 198
Cdd:cd17355 117 VAAWWFERRRGLALGILTAGGGLG---SLVFLPLGAALIE-----AFGWRTALLVLAllallVLVPVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 199 FKEALKSQEENSHAstglRTVITQYPKQLAVATAVRIGENAMYYlIIAFTLTYLTIFDAMTSQDVLLIMFIAnIVQFFSM 278
Cdd:cd17355 189 RAYDDASPASPGST----LKEALRSASFWLLALAFFLCGFAVVG-LIVHLVPYLADRGISPAAAAVALALIG-LFNIVGR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 279 IFGGYLSDQIGRRKTYLIGGVLALVwAPFYFPLLNTGSFIIILFAVIFGLVVQSFMyGPEGALFGELFPTRaRYAGVSAA 358
Cdd:cd17355 263 LLSGWLGDRYSPRRLLAASYALRAL-GLALLLLLPFPPLALLLFAALFGLGWGATV-PLTAALAARYFGAR-SYGTLFGL 339
|
330
....*....|....*....
gi 505212428 359 YQLGSILGGSLAPIIAVFL 377
Cdd:cd17355 340 VFAPHQLGSALGPWLGGLL 358
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
52-401 |
1.41e-07 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 53.06 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 52 PLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVWgyaapialAALRFIQGFAVGGEWGGAVLLVGEHSPPE 131
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVY--------CVLRFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 132 QRGYWASYPQAAASVGnvlativllgsNFLLSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVedapifkealksqeensh 211
Cdd:cd17374 121 HRALAITLTSCFFSIG-----------QMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWL------------------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 212 astglrtvitqyPKQLAVATAVRIGeNAMYYLIIAFTLTYLtifdamtSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRR 291
Cdd:cd17374 172 ------------PKRTLILSFVWFA-NSFSYYGLSLDLQHL-------GLNVFLLQFLFGAVEVPARCLALFLLNHMGRR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 292 KTYL------IGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVqSFMYgpegalFGELFPT--RARYAGVSAAYqlgS 363
Cdd:cd17374 232 ISQAvllllaGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTI-SYVY------TAELFPTvlRQTGMGLNSMF---A 301
|
330 340 350
....*....|....*....|....*....|....*....
gi 505212428 364 ILGGSLAPIIavFLWNTFDSWIPIAIY-LFTLLAFSIFS 401
Cdd:cd17374 302 RIGGILAPLI--MLLGVYSPLLPMIIYgVLPILAGLLAL 338
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
53-401 |
1.90e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.01 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapialaalrFIQGFAVGGEWGGAVLLVGEHS---- 128
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV-------------LLVLLFLVGAGYGSVQPGGGRAimrw 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 129 -PPEQRGYWASYPQAAASVGNVLATIVLLgsnfllseEAFLAWGWRIAFWLSAVV-VFIGYYIRKKVEDAPIFKEALKSQ 206
Cdd:cd17475 113 fPPRERGLAMGIRQTGVPLGGALAAALLP--------PLALHYGWRAAFVVAGLVsILAAVLFWLFYREPPAASAATESA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 207 eenSHASTGLRTVITQYPKQLAVATAVRIgeNAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSD 286
Cdd:cd17475 185 ---STLLRSLKEVLRNRDVWLIAIAGALL--VAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 287 QI--GRRKTYL--IGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFmYGPEGALFGELFPtrARYAGVSAAY--- 359
Cdd:cd17475 260 RVfgGRRRPVLviTAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGW-NGLYLTLVAESAG--PEQAGTALGLant 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 505212428 360 --QLGSILGGSLAPIIAVFLWNTFDSWIPIAiyLFTLLAFSIFS 401
Cdd:cd17475 337 inFIGIAIGPPLFGLLVDATHSYAPAWLALA--LLLVLAALLLL 378
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
42-310 |
6.36e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 51.11 E-value: 6.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPdfSVWgyaapiALAALRFIQGFaVGGEWGGAV 121
Cdd:cd17391 40 LAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVT--NVW------QLLILRLLQGV-FSGYVPNAT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 122 LLVGEHSPPEQRGYWASYPQAAASVGNVLATivLLGSnfLLSEeaflAWGWRIAFWLSAVVVFIGYYIrkkvedaPIF-- 199
Cdd:cd17391 111 ALIASQTPKEKSGWALGTLSTGVVAGTLIGP--LLGG--FLAD----LFGIRNVFFITGGLLFLAFLL-------TLFfv 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 200 KEALKSQEENSHASTglRTVITQYP-KQLAVATAVRIgenamyyLIIAFTLT----YLTIFDAMTSQDVLLIMFIANIV- 273
Cdd:cd17391 176 KEDFKPVEKKKMVST--KEVWNSVPnPSLLISLFVTT-------FIIQLANQsiepILTLYIRQLMGDASNLAFISGLVf 246
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 505212428 274 ------QFFSMIFGGYLSDQIGRRKTYLIGGVLAlvwAPFYFP 310
Cdd:cd17391 247 satgvsSLLSAPRLGKLGDRIGHHRILLGALLAS---ALLYIP 286
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
48-404 |
8.57e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 51.09 E-value: 8.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 48 FIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGclpdFSVWGYAAPIALAALRFIQGFAVGGEWGGAVLLVGEH 127
Cdd:cd17345 48 SIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIG----FVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHW 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 128 SPPEQRGYWASYPQAAASVGN-VLATIVLLGSNFllseeaFLAWGWRIAFWLSAVVVFI-GYYIRKKVEDAP-------- 197
Cdd:cd17345 124 FSKKERGTWTSIWNISHNVGGgLVGPLAGLGLAI------FGDGWWRGAFIFPAIIAIIvAVIVLFLGKDTPeseglppi 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 198 -IFKEALKSQEENSHASTGL--RTVITQY----PKQLAVATA------VRIGenamyylIIAFTLTYLTIFDAMTSQDVL 264
Cdd:cd17345 198 eEYKGDYPEEADGEEEEQELsaWEIFVKYvlknKLLWYIAIAnvfvylVRYG-------ILDWAPTYLSEVKGFSKAQAM 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 265 LIMFIANIVQFFSMIFGGYLSDQI--GRR-KTYLIGGVLALVWAPFYFplLNTGSFIIILFAVIFGlvvqSFMYGPE--- 338
Cdd:cd17345 271 WAFSLFEWAAIPGTLLAGWLSDKLfkGRRaPTGIIFMILVIVALIVYW--LAPNVLVDLIALIALG----FLIYGPVmli 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505212428 339 GALFGELFPTRAryAGVSA------AYQLGSILGGSLAPIIA-VFLWN-TFdswipiaIYLFTLLAFSIFSMVY 404
Cdd:cd17345 345 GLQALELVPKKA--AGTAAgltglfGYLGGSVLATALIGIIVdHFGWNgGF-------IVLLASCILAIIFLAL 409
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
38-332 |
9.53e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 9.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 38 LAAFLTYAIGFIARPLggfvFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEW 117
Cdd:cd17478 35 LLVSVFSITSSLLQPL----FGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWL--------LLLLVALAGIGSAAFH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 118 GGAVLLVGeHSPPEQRGYWASYPQAAASVGNVLATIVLLgsnFLLSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAP 197
Cdd:cd17478 103 PEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAA---ALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 198 ifkealksqeeNSHASTGLRTVITQYPKQLAVATAVRIGENAMYYLIIAFTLTYLT--IFDAMTSQDVLLIMFIANIVqf 275
Cdd:cd17478 179 -----------KAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVqrGYSLVFAGLLLSLFLFAGAI-- 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 505212428 276 fSMIFGGYLSDQIGRRKTYLIGGVLAlvwAPFYFPLLNTGSFIIILFAVIFGLVVQS 332
Cdd:cd17478 246 -GTLIGGPLSDRFGRRRVIIASLLLA---APFLLLFLLTPGIWSYILLVLAGFLLFA 298
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
57-388 |
1.29e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 50.27 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 57 VFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAvGGEWGGAVLLVGEHSPPEQRgyw 136
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--------LIAGRALQGIG-GAVFPLAFALVREEFPPERV--- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 137 asyPQAAASVGNVLATIVLLGsnFLLSeeAFLA--WGWRIAFWLSAVVVFIGYYIrkkvedAPIFKEALKSQeenshast 214
Cdd:cd17504 118 ---PVAQGILSATFGIGAGIG--LPLG--GWIVqhLGWRWIFWTAAPVAVLLAAL------VPLIDLRLLRR-------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 215 glRTVITqypkQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTY 294
Cdd:cd17504 177 --RNVLL----ANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 295 LIGGVLALVwaPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELFPtRARYAGVSAAYQLGSILGGSLAPIIA 374
Cdd:cd17504 251 LIGLVISAV--GLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVP-PDRTGIATGMNTVLRTIGSAIGPAIA 327
|
330
....*....|....
gi 505212428 375 VFLWNTFDSWIPIA 388
Cdd:cd17504 328 GAILTTYTVSITSG 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
239-400 |
1.90e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 239 AMYYLIIAFTLTYLTIFDaMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWapFYFPLLNTGSFI 318
Cdd:pfam07690 11 GRSLLGPALPLLLAEDLG-ISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALG--LLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 319 IILFAVIFGLVvQSFMYGPEGALFGELFPTRAR---YAGVSAAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLL 395
Cdd:pfam07690 88 LLVLRVLQGLG-AGALFPAALALIADWFPPEERgraLGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
....*
gi 505212428 396 AFSIF 400
Cdd:pfam07690 167 LLLLP 171
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
48-416 |
2.09e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 49.88 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 48 FIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAVLLVGEH 127
Cdd:cd17358 51 TLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWM--------LYLGRFLAGFGGGAASVVVPVYIAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 128 SPPEQRGYWASYPQAAASVGnvlatiVLLGsnFLLSeeAFLAwgWRIAFWLSA---VVVFIG---------YYIRKKVE- 194
Cdd:cd17358 123 APKNVRGALGSLNQLLVNIG------ILLG--YVLG--SFLP--WRTLALIGAippVVFLILlffipesprWLAKKGREe 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 195 ------------DAPIFKEALKSQEENSHASTGLRTVITQ------YPKQLAVATAVRI-----GENAMyyliiaftLTY 251
Cdd:cd17358 191 eaekslqflrgkDADISKEAAEIQEELAELEKEAKESSFSdlfqrkYLKPLVIGLGLMLfqqlsGINAV--------IFY 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 252 L-TIFD-AMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGV-----LALVWAPFYF---PLLNTGSFIIIL 321
Cdd:cd17358 263 AsSIFDeAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIgmgigLLALGLYFYLqehGALLSSVSWLPL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 322 FAVIFGLVVQSFMYGP-EGALFGELFPTRARyagvsaayqlgsILGGSLapiiaVFLWNTFDSWIPIAIYLFTLLAFS-- 398
Cdd:cd17358 343 VGLVIYIISFSIGLGPlPWVIMSEIFPAKIK------------GLAGSL-----VTLVNWLFAFIVTKTFPFLTLAWGas 405
|
410 420 430
....*....|....*....|....*....|.
gi 505212428 399 ----IFSMVYG---------VKETSGTLLED 416
Cdd:cd17358 406 gtfwIFAGICGlalvfvllfVPETKGKSLEE 436
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
54-377 |
3.01e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.19 E-value: 3.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 54 GGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSvwgyaapiALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQR 133
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFP--------SLLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 134 GYWASYPQAAASVGNVLATIVLLgsnfLLSEEAflawGWRIAFWLSAVV-VFIGYYIRKKVEDAPIFKEALKSQEENSHA 212
Cdd:PRK11551 138 GTAVSLMYCGVPFGGALASVIGV----LAAGDA----AWRHIFYVGGVGpLLLVPLLMRWLPESRAFAQAAGAGKQRAPV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 213 STGL----RTVITqypkqLAVATAVRIGENAMYYLIiaFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQI 288
Cdd:PRK11551 210 LRALfgegRATAT-----LLLWISYFFTLIVLYFLL--NWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 289 GRRKTYL------IGGVLALVWAPfYFPLLNTGSFIIILFAVifglVVQSFMYgpegALFGELFPTRARYAGVSAAY--- 359
Cdd:PRK11551 283 RPRRVVLliyagiLASLAALAAAP-SFAGMLLAGFAAGLFVV----GGQSVLY----ALAPLFYPTQVRGTGVGAAVavg 353
|
330
....*....|....*...
gi 505212428 360 QLGSILGgslaPIIAVFL 377
Cdd:PRK11551 354 RLGSMAG----PLLAGQL 367
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
53-404 |
3.52e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 48.73 E-value: 3.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGgewGGAVL---LVGEHSP 129
Cdd:cd17320 49 LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAA---AGSVVaraIVRDLYS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 130 PEQRGYWASYPQAAASVGNVLATivLLGSnFLLseeafLAWGWRIAFW---LSAVVVFIGYYIRkkvedapiFKEALKSQ 206
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALAP--LLGG-LLL-----LFFGWRAIFVflaLLGLLLLLLVLLF--------LPETLPEE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 207 EenshASTGLRTVITQYPKQLAVATAVrigenaMYYLIIAFTLTYLTIFDAMT----------SQDVLLIMFIANIVQFF 276
Cdd:cd17320 182 K----RKPLLSSLLRAYKRVLKNRRFL------GYALALGLSFAGLFAYLAAApfiyieqlglSPAQFGLLFALNAIALI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 277 SM-IFGGYLSDQIGRRKTYLIGGVL----ALVWAPFYFPLLNTGSFIIILFAVIFGLVvqSFMYGPEGALFGELFPTRAr 351
Cdd:cd17320 252 LGsLLNGRLVRRFGPRRLLRLGLLLllaaALVLLLAALLGGLSLWPLVAPLFLIFFGF--GLIFPNATSLALEPFPHVA- 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 505212428 352 yAGVSAAYQLGSILGGSLAPIIAVFLWNTfdSWIPIAIYLFTLLAFSIFSMVY 404
Cdd:cd17320 329 -GTASALLGFLQFLIGALAGALVGLLPNG--TALPMGLLILVLGLLALLLLIL 378
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
48-400 |
3.55e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.81 E-value: 3.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 48 FIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGclpdfsvWGYAAPIaLAALRFIQGFAVGGEWGGAVLLVGEH 127
Cdd:cd17312 48 LIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMG-------FSTSLWF-FAVLWGLNGLFQSMGWPPCVKLLGNW 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 128 SPPEQRGYWASYPQAAASVGNVLATIVLLGsnfllseeAFLAWGWRIAFWLSAVVVFIGYYIRKKvedapifkealksqe 207
Cdd:cd17312 120 FSKKERGTVYGIWSTSHNFGGILAPILAAS--------LASYYGWRAAFLVPGIVGLVVAIILFF--------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 208 enshastglrtVITQYPKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQ 287
Cdd:cd17312 177 -----------FLRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDK 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 288 IGRRKTYLIGGVLAlvwapfyfpLLNTGSFIIILFA-------VIFGLVVQSFMYGPE---GALFGELFPTRARYAGVSA 357
Cdd:cd17312 246 LFGGRRAPIAVIYM---------LLMTLSLALFWFFphnkllsIVLLFLIGFFVGGPInliGGAAAQDIGRKEAAGTATG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 505212428 358 AYQLGSILGGSLAP-----IIAVFLWNTFdSWIPIAIYLFTLLAFSIF 400
Cdd:cd17312 317 FVGLFGYLGASLAGlplgyIIDHYGWSTV-FYFLISAALLSVLLLLSL 363
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
53-417 |
4.30e-06 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 48.50 E-value: 4.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAVLLVGEHSPPEQ 132
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPV--------LLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 133 RGYWASYPQAAASVGNVLATIVllGSNFllseeAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEalksqeensha 212
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVS--GYAF-----ADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRWQG----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 213 stglrtvitQYPKQLAVATAVRI------GENAMYYLIiaftltylTIFDAM---TSQDVLLIMFIANIVQFFSMIFGGY 283
Cdd:cd17362 188 ---------NYRKPLIIGLGLVLfqqitgQPSVLYYAA--------TIFKSAgfsAASDATLVSVGLGVFKLLMTIVAVL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 284 LSDQIGRRKtYLIGGVLALVWAPF-----YFPLLNTGSFIIILFAVIFGLVVQSFM--YGPEGALF-GELFP--TRARYA 353
Cdd:cd17362 251 LVDKLGRRP-LLLGGVSGMVVSLFllaayNLFVQMGPAGLAWLSLVALLLYVGAYQisFGPISWLMvSEIFPlrVRGRAI 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505212428 354 GVSAAYQLGSILGGSLApiiavFLWNTFDSWIPIAIYLFTLLA-FSIFSMVYGVKETSGTLLEDV 417
Cdd:cd17362 330 ALAVLVNFGSNALVSLA-----FLPLQELIGLPGTFLGFGVIGvLALLFIYFTVPETKGLSLEEI 389
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
52-334 |
4.97e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 4.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 52 PLGGFvfgqLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAVLLVGEHSPPE 131
Cdd:cd17503 49 PLSGW----LADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 132 QRGYWASYPQAAASVGNVLATIVllgSNFLLSeeaflAWGWRIAFWLSAVVVFIGYYIrkkvedAPIFK-EALKsqeens 210
Cdd:cd17503 117 KRGAAMGLVGLVILLAPAIGPTL---GGWLTD-----NLSWRWIFYINLPIGILALLL------APLLDlRLFK------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 211 HASTGLRTVITqypkqlavaTAVRIGENAMYYLIIAFTLTYLTiFDAMTSQdvlLIMFIANIVQFFSMIFGGYLSDQIGR 290
Cdd:cd17503 177 DRNFTLGLLLS---------FLLGLGLFGAMFLLPLYLQNVLG-YSAFESG---LVLAPGGLASAILSPLVGRLLDKFGP 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 505212428 291 RKTYLIG-GVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFM 334
Cdd:cd17503 244 RLLLLAGlLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVF 288
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
49-381 |
1.19e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 47.37 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 49 IARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPdfSVWgyaapiALAALRFIQGFAVGGEWGGAVLLVGEHS 128
Cdd:TIGR00881 41 IAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST--SLW------VMAALWALNGIFQGMGWPPCGRTVTKWF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 129 PPEQRGYWASYPQAAASVGNVLAT-IVLLGSNFLlseeaflaWGWRIAFWLSA----VVVFIGYYIRK---------KVE 194
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAEL--------YSWHWVFIVPGiiaiIVSLICFLLLRdspqscglpPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 195 DAPI--FKEALKSQEENSHASTGLRTVITQYPKQLAVATAvrigeNAMYYLIIAFTLTYLTIF-------DAMTSQDVLL 265
Cdd:TIGR00881 185 EMPNeePDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLG-----YVFVYVVRTGILDWSPLYltqekgfSKEKASWAFT 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 266 IMFIANIVqffSMIFGGYLSDQIGRRKTYLIG-----GVLALVWAPFYFPLLNTGSFIIILFAVIFglvvqsFMYGPE-- 338
Cdd:TIGR00881 260 LYELGGLV---GTLLAGWLSDKLFNGRRGPLAvffmaLIIVSLLVYWLNPAANPLMDLICLFALGF------LVYGPQml 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 505212428 339 -GALFGELFPTRAryAGVSAAYQ-LGSILGGSLAP-----IIAVFLWNTF 381
Cdd:TIGR00881 331 iGVIASELAPKKA--AGTAAGFVgFFAYLGGILAGlplgyLADGFGWAGA 378
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
48-393 |
1.45e-05 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 47.14 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 48 FIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSvWgyaapiaLAALRFIQGFAVGGEWGGAVLLVgEH 127
Cdd:cd17372 44 FAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYM-W-------LIILRCLVGLGLGGGPQLASWYL-EF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 128 SPPEQRGYWASYPQAAASVGNVLatIVLLGSNFLLSeeafLAWGWRIAFW---LSAVVVFIGYYIRKKVEDAPIFKealk 204
Cdd:cd17372 115 LPAKSRGTWMVLFSVFWTVGTIF--EASLAWLVMPR----LGWRWLLAFSsvpSSLLLVFYRWTPKTTLLLWVIWF---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 205 sqeENSHASTGLRTVITQYpkqlaVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDvlliMFIANIVQFFSMIFGGYL 284
Cdd:cd17372 185 ---GNAFAYYGVVLLTTEL-----NNSHNVCGSKSDSDSGESPTEKQCRNSNDVDYRD----VFIATFAEFPGLLISAAM 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 285 SDQIGRRKTYliggVLALVWAPFYFPLLN--TGSFIIILF-----AVIFGLVVQSFMYGPegalfgELFPTRARYAGVSA 357
Cdd:cd17372 253 IDRLGRKASM----ASMLFTCCIFLLLLLicQSPFILTVLlfggrACISAAFTVVYIYTP------EVYPTAVRALGVGT 322
|
330 340 350
....*....|....*....|....*....|....*.
gi 505212428 358 AYQLGSIlGGSLAPIIAVFLwntFDSWIPIAIYLFT 393
Cdd:cd17372 323 GSSVGRI-GAILCPFIAQVL---VHGSQTIALLLFS 354
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
30-358 |
1.80e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 46.49 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 30 GGNPLDAVLAAFLTyAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQ 109
Cdd:cd17360 28 GEVVLSTGWQELIV-SSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEV--------LIVGRVLV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 110 GFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNFLLSeeaflawGWRIAFWLSAVVVFIGYYI 189
Cdd:cd17360 99 GLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPG-------GWRWMLGLAAVPAVLQFIG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 190 RKKVEDAPIFKEALKSqeenSHASTGLrtvitQYPKQLAVATAVrigenaMYYliiaftltYLTIFDAMTSQDVLLIMFI 269
Cdd:cd17360 172 LLFLPESPRWPSTRRA----LIVGCGL-----QAFQQFSGINTV------MYY--------SATILQMAGFKDNQNAIWL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 270 ANIVQFFSMIF---GGYLSDQIGRRKTYLIGGVLALVwapfyfPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELF 346
Cdd:cd17360 229 SLIVAGTNFIFtivGMYLIDKFGRRKLLLISLFGVIV------ALVVLAVWLALVGLILYLAFFAPGMGPVPWTVNSEIY 302
|
330
....*....|..
gi 505212428 347 PTRARYAGVSAA 358
Cdd:cd17360 303 PLWARGTGGGCA 314
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
265-409 |
2.44e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.05 E-value: 2.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 265 LIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWAPFYfpLLNTGSFIIILFAVIFGLVVQSFmyGPEGALFGE 344
Cdd:cd17489 35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY--LLATSVALLLVLRLIHGIGWGAF--TTAAATLVA 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505212428 345 LFPTRARYAGVSAAYQLGSILGGSLAPIIAVFLWNTFDswIPIAIYLFTLLAFSIFSMVYGVKET 409
Cdd:cd17489 111 DIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAAVLALLALLLVFLVKDP 173
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
42-400 |
2.51e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 2.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFvfgqLGDRFGRKKMLqvslIMIGVA-TFLMGCLPDFSVWgyaaPIALAALRFIqgfavgGEWGGA 120
Cdd:cd17370 42 LAEALGSLLRLFSGY----LSDRTGKRKPL----VILGYGlSALAKPLLALAGS----WQLVLLLRIL------ERLGKG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 121 VL------LVGEHSPPEQRGyWA-----SYPQAAASVGNVLATIVLlgsnfllseeAFLAWGWRIAFWLSAVV----VFI 185
Cdd:cd17370 104 IRtpprdaLLADATPPSGRG-KAfglhrALDTLGAVLGPLLAALLL----------YLLGGNYRTIFLLAAIPallaLLI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 186 GYYIRKKVEDAPIFKEALKSqeenshasTGLRTVITQYPKQLAVATAVRIGENAMYYLIIAFTLTyltifdAMTSQDVLL 265
Cdd:cd17370 173 LLFVVKEYPRPPKLRKKSKK--------TSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQEL------GLSAALIPL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 266 IMFIANIVQFFSMIFGGYLSDQIGRRKTyLIGGVLALVWAPFYFPLLNTGSFIIILFAvIFGLVVqSFMYGPEGALFGEL 345
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKL-LILGYLSLALAYLGFALGSSLWLLLLGFI-LWGLYM-GAQESIERAAVADL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 505212428 346 FPTRARyAGVSAAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIF 400
Cdd:cd17370 316 VPAELR-GTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
11-186 |
2.65e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.01 E-value: 2.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 11 FFIYGTAAALVFSVTFFPNGGNPLDAVLA--AFLTYAIGFIarpLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCL 88
Cdd:cd17321 178 FLLGAALGGLLFLLPLYLQGVLGYSPLQAglALLPLALAML---VAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALL 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 89 P-DFSVWGYAAPIALAalrfiqGFAVGGEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLAtIVLLGSNFLLSEEAF 167
Cdd:cd17321 255 GaDSSVWLLLPGLVLL------GLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG-VALLGALLTAGLSAN 327
|
170 180 190
....*....|....*....|....*....|....*
gi 505212428 168 LAW----------------GWRIAFWLSAVVVFIG 186
Cdd:cd17321 328 LGDsgvaallsaaaaafaaGFHLAFLVAAALALLA 362
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
53-417 |
2.66e-05 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 46.24 E-value: 2.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGGAVLLVGEHSPPEQ 132
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPV--------LMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 133 RGYWASYPQAAASVGNVLATIvllgSNFLLSEEAfLAWGWRIAFWLSAV-VVFIGYYIRKKVEdAPIFKEALKsqeensh 211
Cdd:cd17437 119 RGFLTSFPEIFINIGILLGYV----SNYAFSGLP-LHVGWRLMLGVGAVpSLFLAIGVLAMPE-SPRWTPAVR------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 212 astglrtvitqypKQLAVATAVRIGENAMYylIIAFTLTYLTIFD--AMTSQDVLLIMFIA-NIVQFFSMIFGGYLSDQI 288
Cdd:cd17437 186 -------------RMLIAALGIHFFQQASG--IDAVVLYSPRIFKkaGIKSKDKLLLATVAvGVTKTLFILVATFLLDKV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 289 GRRK---TYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFM------YGPEGALFG-ELFPTRARYAGVSAA 358
Cdd:cd17437 251 GRRPlllTSTGGMTLSLTALATSLTFIDRNGGGLTWALVLAITAVCSFVaffsigAGPITWVYSsEIFPLRLRAQGASLG 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 359 YQLGSILGGSLApiiAVFLWNTFDSWIPIAIYLFTLLAFSIFSMVYG-VKETSGTLLEDV 417
Cdd:cd17437 331 VVVNRLMSGTVS---MTFLSMSKAITTGGTFFLFAGVAAAAWVFFYFfLPETKGKSLEEI 387
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
42-182 |
2.83e-05 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 45.88 E-value: 2.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMigvaTFLMGCLPDFSVwgyaAPIALAALRFIQGFAVGGEWGGAV 121
Cdd:cd17447 39 ATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVL----SLVFGLASAFSV----SYVMFAITRTLTGFALTGFSIISM 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505212428 122 LLVGEHSPPEQRgywasypqaaaSVGNVLATIVLLGSNFLLSEEAFLAWGWRiafWLSAVV 182
Cdd:cd17447 111 VLCVEWVDIEHR-----------TVAGVLISLFWTVGNMLLALVAYLIRDWR---WLILAV 157
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
34-407 |
3.25e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 34 LDAVLAAFLTYAIgFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAV 113
Cdd:COG0738 40 LSDAQAGLLLFAF-FLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL--------LLLALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 114 GGEWGGAVLLVGEHSPPEQRGYWASYpQAAASVGNVLAtiVLLGSNFLLSEeafLAWGWRIAFWLSAVVVFIGYYIRKKV 193
Cdd:COG0738 111 GLLDVAANPYVAALGPETAASRLNLL-HAFFSLGALLG--PLLGGLLILLG---LSLSWHLPYLILAVLLLLLALLFLRS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 194 EdapiFKEALKSQEENSHASTGLRTVITQypKQLAVATAVRIGENAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIV 273
Cdd:COG0738 185 K----LPEIEEEEEEAAGSAASLKSLLKN--PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 274 QFFSMIFGGYLSDQIGRRKTYLIGGVLALVwaPFYFPLLNTGSFIIILFAVIFGLVVqsfmygpeGALFGELFPTRARYA 353
Cdd:COG0738 259 MTIGRFLGGFLLKRFGPVRLLRLSALLAAV--GLLLALLAPGPWLALIGLALVGLGL--------SLMFPTIFSLALDGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 505212428 354 GVSAAYQLGSIL-----GGSLAPIIAVFLWNTFDswipIAIYLFTLLAFSIFSMVYGVK 407
Cdd:COG0738 329 GKRTAAAVSAVLimgivGGAIGPPLIGFLADAFG----LRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
15-186 |
3.37e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 46.03 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 15 GTAAALVFSVTFFPNGGNPLDAVLAAFLTyaigFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLpdFSVW 94
Cdd:cd17358 255 GINAVIFYASSIFDEAGSGLDPNTATIII----GVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLY--FYLQ 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 95 GYAAP------IALAALR-FIQGFAVGgeWGG-AVLLVGEHSPPEQRGYWASYpqaAASVGNVLATIVLLGSNFLLseea 166
Cdd:cd17358 329 EHGALlssvswLPLVGLViYIISFSIG--LGPlPWVIMSEIFPAKIKGLAGSL---VTLVNWLFAFIVTKTFPFLT---- 399
|
170 180
....*....|....*....|
gi 505212428 167 fLAWGWRIAFWLSAVVVFIG 186
Cdd:cd17358 400 -LAWGASGTFWIFAGICGLA 418
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
53-181 |
4.45e-05 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 45.79 E-value: 4.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKmlqvSLIMIGVATFLMGCLPDFSVWGYAAPIALAAlRFIQGFAVGGEWGGAVLLVGEHSPPEQ 132
Cdd:cd17431 65 IGSFSVGLFVNRFGRRN----SMLYNNLLAFAGAALMGLSKLAKSYEMLILG-RFIIGLYCGLTTGLVPMYIGEISPTAL 139
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 505212428 133 RGYWASYPQAAASVGNVLATIvlLGSNFLLSEEAflawGWRIAFWLSAV 181
Cdd:cd17431 140 RGALGTLHQLGIVVGILISQI--FGLEFILGTEE----LWPLLLGFTIV 182
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
241-400 |
5.43e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.30 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 241 YYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIII 320
Cdd:cd17329 15 FFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 321 LFAVIFGlvvQSFMYGPEGALFGELFPTRAR---YAGVSAAYQLGSILGgslaPIIAVFLWNTFDSWIPIAIYLFTLLAF 397
Cdd:cd17329 95 LVLTGFG---GGLFEPASEAMIADVTTPENRtraFSLLYWAINLGVAIG----PLLGGLLLLYSFRLLFLAAAVLFLLAA 167
|
...
gi 505212428 398 SIF 400
Cdd:cd17329 168 LVL 170
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
45-150 |
5.76e-05 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 45.03 E-value: 5.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 45 AIGFIarpLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFsvwgyaapIALAALRFIQGFAVGGEWGGAVLLV 124
Cdd:cd17379 43 NLGFL---IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMTGYVLV 111
|
90 100
....*....|....*....|....*.
gi 505212428 125 GEHSPPEQRGYWASYPQAAASVGNVL 150
Cdd:cd17379 112 TEFVGSKYRRTVGIVYQMFFTLGLLI 137
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
238-377 |
7.51e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 7.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 238 NAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGgvlALVWAPFYFPLLNTGSF 317
Cdd:COG2271 22 NYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG---LLLWGLATLLFGFATSF 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 318 IIILFAVIFGLVVQSFMYGPEGALFGELFPTRaRYAGVSAAYQLGSILGGSLAPIIAVFL 377
Cdd:COG2271 99 WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK-ERGRALGIFNAGGPLGGALAPPLLGWL 157
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
238-400 |
8.12e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.72 E-value: 8.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 238 NAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVwapFYFPLLNTGSF 317
Cdd:cd06174 8 TGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFAL---GALLFAFAPSF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 318 IIILFAVIFGLVVQSFMYGPEGALFGELFPTRAR---YAGVSAAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTL 394
Cdd:cd06174 85 WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERgraLGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALL 164
|
....*.
gi 505212428 395 LAFSIF 400
Cdd:cd06174 165 AAILLL 170
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
238-400 |
1.68e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.77 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 238 NAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVwapfyfpllntgSF 317
Cdd:cd06179 9 AQLFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVV------------GS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 318 IIILFA-----VIFGLVVQSFMYGPEGALF---GELFPTRARYAGVSAAYqLGSILGGSLAPIIAVFLWNTFDS------ 383
Cdd:cd06179 77 IVAGTAksvnmLIGGQALIGIGAGTQGLGAavaSELVPNKYRGLVQGVVN-LVASPGSALGPLIAGALVEANAAgwrwif 155
|
170
....*....|....*..
gi 505212428 384 WIPIAIYLFTLLAFSIF 400
Cdd:cd06179 156 YINAIFNALALILLFFF 172
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
8-403 |
4.36e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 4.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 8 WYEFFIYG-TAAALVFSVTFFPNGGN-PLDAVLAAFLTYAIGFIarpLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLM 85
Cdd:cd17333 2 YISFFSNGlTDALLGILGPSLEEAFNlNVADVSVIFSSQNAGYL---IGSLLAGFLMKRLGRRRTLILGLLLISLALALI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 86 GCLPDFsvwgyaapIALAALRFIQGFAVGGEWGGAVLLVGEHSpPEQRGYWASYPQAAASVGnvlATIVLLGSNFLLSEE 165
Cdd:cd17333 79 FATPSI--------YLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLG---ALIGPLIATSLLTSE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 166 AFLAWGWRIAFwLSAVVVFIGYYIRKKVEDAPIFKEALKSQEENSHASTGLRTvitqyPKQLAVATAVRIGENAMyYLII 245
Cdd:cd17333 147 LSWSWAYLIIG-LIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRN-----PSIILGALALFLYVGAE-TAFS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 246 AFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVwapFYFPLLNTGSFIIILFAVI 325
Cdd:cd17333 220 SWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALL---GLLILLLAPTLVVGLVATA 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505212428 326 FGLVVQSFMYgPEGALFGELFPTRARYAGVSAAYQLGSIlGGSLAPIIAVFLWNTFDswIPIAIYLFTLLAFSIFSMV 403
Cdd:cd17333 297 LLGLFMAALF-PTILSLGISNLPYAKGKGTSVLLAAGSI-GGAIIPFIMGFIAEAVG--IQTAMLLITILYAIIFVLA 370
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
57-330 |
7.03e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.68 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 57 VFGQLGDRFGRKK-MLQVSLIMIGVATFLMGCLPDFSVWGYAAPIALAALRFiqgfavggeWGGAVL---LVGEHSPPEQ 132
Cdd:COG2270 71 VLGAIADRSGRKKpFLAFFTLLGVLATAALFFVAPGGLWLGLLLFVLANIGF---------EGSLVFynaFLPDIATPEE 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 133 RGYWASYPQAAASVGNVLATIVLLGsnFLLSEEAF----LAWGWRIAFWLSAVVvFIGYYIrkkvedaPIFkeaLKSQEE 208
Cdd:COG2270 142 IGRVSGLGWALGYLGGVLLLLINLA--LFLKPEAFglpdAGEAVRISFLLTALW-WLLFAL-------PLF---LFLPER 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 209 NSHASTGLRTVITQYPKQL-AVATAVRIGENAMYYLI--------IAFTLTYLTIFDA----MTSQDVLLIMFIANIVQF 275
Cdd:COG2270 209 PRPGPAPPRGAVRAGFRELrRTLRELRRYRDLLRFLLayffyrdgVQTVIAFAGIYAAgvlgFSTTELIVFGLLVQIVAA 288
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 505212428 276 FSMIFGGYLSDQIGRRKTY---LIGGVLALVWAPFyfpLLNTGSFIIilFAVIFGLVV 330
Cdd:COG2270 289 LGALLFGRLDDRIGPKRVIlvsLVIWIVVCLAAYF---LTTALAFWI--LGLLIGLVM 341
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
276-373 |
7.23e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.77 E-value: 7.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 276 FSMIFGGYLSDQIGRRKTYLIGgvlALVW--APFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELFPTRAR-- 351
Cdd:cd17380 49 LTQVLGGYLADRFGGKKVLLLA---VALWslATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERsr 125
|
90 100
....*....|....*....|...
gi 505212428 352 -YAGVSAAYQLGSILGGSLAPII 373
Cdd:cd17380 126 aVSIVTAGSYLGTLLGGLIGPLL 148
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
48-134 |
7.27e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 41.58 E-value: 7.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 48 FIARPLGGFVFGQLGD-RFGRKKMLQVSLIMIGVATFLMGCLPdfSVWGYAApialaaLRFIQGFAVGGEWGGAVLLVGE 126
Cdd:cd17378 43 FVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSP--NYWVYAF------LRFLTGFGRSGIGTCALVLATE 114
|
....*...
gi 505212428 127 HSPPEQRG 134
Cdd:cd17378 115 PVGPKWRG 122
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
244-403 |
7.37e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 7.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 244 IIAFTLTYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVwapFYFPLLNTGSFIIILFA 323
Cdd:COG2814 28 IVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL---GSLLCALAPSLWLLLAA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 324 VIFGLVVQSFMYGPEGALFGELFPTRARyAGVSAAYQLGSILGGSLAPIIAVFLWNTFD-SWIPIAIYLFTLLAFSIFSM 402
Cdd:COG2814 105 RFLQGLGAGALFPAALALIADLVPPERR-GRALGLLGAGLGLGPALGPLLGGLLADLFGwRWVFLVNAVLALLALLLLLR 183
|
.
gi 505212428 403 V 403
Cdd:COG2814 184 L 184
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
53-185 |
1.11e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.02 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSvwgyaapiALAALRFIQGFavggeWGGAVLLVGEHS---- 128
Cdd:cd17323 49 LGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA--------MLIILRFLQGF-----FGSSPLAIGAGTiadl 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 505212428 129 -PPEQRGYWASYPQAAASVGNVLATIVllgSNFLLSeeaflAWGWRIAFWLSAVVVFI 185
Cdd:cd17323 116 fTPEERGKAMGVYSLGPLLGPALGPII---GGFITQ-----SLGWRWIFWFLAIISGF 165
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
41-183 |
1.13e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 39.17 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 41 FLTYAIG-FIARPLGGFvfgqLGDRFGRKKMLQVSLIMIGVATFLMGCLPDFSVwgyaapiaLAALRFIQGFAVGGEWGG 119
Cdd:TIGR00880 4 LAGYALGqLIYSPLSGL----LTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVA 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505212428 120 AVLLVGEHSPPEQRGYWASYPQAAASVGNVLAtiVLLGSnfLLSEeaflAWGWRIAFWLSAVVV 183
Cdd:TIGR00880 72 GAALIADIYPPEERGVALGLMSAGIALGPLLG--PPLGG--VLAQ----FLGWRAPFLFLAILA 127
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
224-381 |
2.08e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 40.25 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 224 PKQLAVATAVRIGENAMYYLIIAFTLTYLT--IFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQI-GRRKTYLIGGVL 300
Cdd:cd17346 1 PKGLYTLFFTEMWERFSYYGMRAILILYLTaqLGDGFSEADAASIYGAYTALVYLTPIIGGWLADKVlGARRTVFIGGIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 301 -ALVWAPFYFPLLNTGSFIIILFAVIFGlvvQSFMYGPEGALFGELFP-TRARYAGVSAAYQLGSILGGSLAPIIAVFLW 378
Cdd:cd17346 81 mALGYLLLALSPFSVSMLYLGLALIIVG---NGLFKPNISSLVGKLYDeNDPRRDSGFSIFYMGINLGAFLAPLLCGTLG 157
|
...
gi 505212428 379 NTF 381
Cdd:cd17346 158 DNY 160
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
40-351 |
2.92e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.54 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 40 AFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGclpdFSVWGYAApiaLAALRFIQGFAvGGEWGG 119
Cdd:cd17341 36 IGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA----LAVSSYWG---LLVLGFLLGFA-GANFAS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 120 AVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLLGSNFLLSEEAFlAWGWRIAFWLSA---VVVFIGYYIRKKveDA 196
Cdd:cd17341 108 GQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGG-FVGWRNAFFVPGillAIAAVLVLLFGD--DL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 197 PifkealksqeenshasTGLRTVITQYPKQLAVATAVRIGENAMYYLI-----IAFTL---TYLTIFDAMTSQDVLLIMF 268
Cdd:cd17341 185 P----------------TGKASALEFLKVQLAVLKNYRTWILSLLYGVtfgsfVGFSNvlpTYFKTRFGLPLVTAGILAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 269 IANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFgLVVQSFMYGPEGALFGeLFPT 348
Cdd:cd17341 249 LFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALF-VALGLGAGAGNGSVFR-MVPF 326
|
...
gi 505212428 349 RAR 351
Cdd:cd17341 327 IFR 329
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
58-402 |
3.23e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 58 FGQLGDRFGRKKMlqvslIMIGVATFLMGCLpdfsVWGYAAPIA-LAALRFIQGfavGGEWGGAVL-LVGEHSPPEQRGy 135
Cdd:cd17472 52 FGLLSDRIGRKPV-----ILFGLLLFIAGSL----LAAYATSIYgLILGRALQG---SGAISSVVMaLLADLTREENRT- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 136 wasypQAAASVGNVLATIVLLGsnFLLSEEAFLAWGWRIAFWLSAVVVFIGYYIrkkvedAPIFKEALKSQEENSHASTG 215
Cdd:cd17472 119 -----KAMALIGASIGIAFAIS--MVLGPLLAAHLGVSGLFLITAILSLVSLLI------LLFFVPDPPKIVQISEKEKK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 216 LRTVITQYPKQLAVATAVRIgenAMYYLIIAFTLTYLTIFDAMTSQDVLLIMFI-ANIVQFFSMIFGGYLSDQIGRRKTY 294
Cdd:cd17472 186 KLKKLLKNKRLLRLDFSIFI---LHFVLMAFFYILPLLLTQLGGGKGQLWKVYLpAILIGFILMVPFVIYAEKKGKMKQV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 295 LIGGVLALVwAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELFPTRARYA--GVSAAYQ-LGSILGGSLAP 371
Cdd:cd17472 263 FVSSILLIA-VGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTamGIYNTSQfLGSFLGGALGG 341
|
330 340 350
....*....|....*....|....*....|.
gi 505212428 372 IIAVFLwnTFDSWIPIAIYLFTLLAFSIFSM 402
Cdd:cd17472 342 LLWGLL--GYSSVFLTILILALLWLLVSFLL 370
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
57-375 |
4.39e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.08 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 57 VFGQLGDRFGRKKMLqvsliMIGVATFLMGCLpdfsvWGYAAP--IALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQRG 134
Cdd:cd17502 49 IYGKLSDLFGRKWVL-----LIAIVIFELGSL-----LCGLAPnmTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 135 YWASYPQAAASVGNVLATIvlLGSNFLLSeeaflaWGWRIAFWLSavVVFIGYyirkkvedapifkealksqeenshAST 214
Cdd:cd17502 119 KYQGYIGAVFGIASVAGPL--IGGAFTDH------LSWRWCFYIN--LPIGGL------------------------ALA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 215 GLRTVITQYPKQLAVATAVRIgenAMYYLIIAFTLTYLtiFDAMTSQDVLLIMFIANIVqfFSMIFGGYLSDQIGRRKTY 294
Cdd:cd17502 165 LLRTILLSSIFGFLFGGALFG---LIYYLPLYFQLVLG--DSATKSGVRLLPLIIGLVI--GSIISGALISKTGRYKPLI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 295 LIGGVLALVWAP-FYFPLLNTGSFIIILFAVIFGL----VVQSFMYGPEGALFGELFPTRAryAGVSAAYQLGSILGGSL 369
Cdd:cd17502 238 VIGTILMSVGAGlLTTLTLDTSKWLLIGYLILLGLglgiGFQQPLVAVQNAVPPADVGVAT--ATNTFFRSLGGTLGVAI 315
|
....*.
gi 505212428 370 APIIAV 375
Cdd:cd17502 316 TDVFLV 321
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
53-395 |
4.39e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 53 LGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPDfsvwgyaaPIALAALRFIQGFAVGGEWGGAVLLVGEHSPPEQ 132
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--------PWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 133 RGYWASYPQAAASVGNVLATivLLGSNFLLSEEAFLAWGWRIAFWLSAVVVFIGYYIRKKVEDAPIFKEALKsqeensha 212
Cdd:cd17329 122 RTRAFSLLYWAINLGVAIGP--LLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILR-------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 213 stGLRTVITQYPKQLAVATavrigeNAMYYLIIAFTLTYLTIF---DAMTSQDVLLIMFIANIVqfFSMIFGGYLSDQIG 289
Cdd:cd17329 192 --GYKIVLRDRAFLLFLLA------SFLISLIYFQLESTLPVYvveILGLGESLLGLLLALNAL--LIVLLQFPVARLVE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 290 RRKTYLIGGVLALVWAPFYFPLLNTGSFIIILFAVIFGLVVQSFMYGPEGALFGELFPTRARyAGVSAAYQLGSILGGSL 369
Cdd:cd17329 262 RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKR-GSYMGFYALAWGLGRAI 340
|
330 340
....*....|....*....|....*.
gi 505212428 370 APIIAVFLWNTFDSWIPIAIYLFTLL 395
Cdd:cd17329 341 GPLVGGLLLDLLGPGLPWLILAALGL 366
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
37-186 |
4.61e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.08 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 37 VLAAFLTYAIGFIARPLGGFVFGQLGDRFGR--KKMLQVSLIMIGVATFLMGCLPDfsvwgyaaPIALAALRFIQGFAVG 114
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPS--------PALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505212428 115 GEWGGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLlgsNFLLSeeaflAWGWRIAFWLSAVVVFIG 186
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLV---GYLLD-----ATGYQAAFLLLAALALLA 350
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
169-397 |
5.11e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.07 E-value: 5.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 169 AWGWRIAFWLSAVV-VFIGYYIRKKVEDAPIFKEALKSQEENSHASTGLRTVItqypkqLAVATAVRIGENAMYylIIAF 247
Cdd:cd17471 151 VLGFTGLFLLAALLyLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLL------LFAAFTLLFAANSMY--IIAM 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 248 TLtYLTIFDAMTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVwapFYFPLLNTGSFIIILFAVIFG 327
Cdd:cd17471 223 PL-YVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVL---FYLGLALATSLWQLIALQLLN 298
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505212428 328 LVVQSFMYGPEGALFGELFPTRARYAgvSAAY----QLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAF 397
Cdd:cd17471 299 AIFIGITAGLGISYFQDLMPGQPGLA--TTLYsnasRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
39-370 |
5.67e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 5.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 39 AAFLTYAIGFIARPLGGFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGclpdfsvwgYAAPIALAALRF--IQGFAVGGE 116
Cdd:cd17353 39 SVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSA---------FAISLPLLFLGYgvLGGIGAGIG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 117 WGGAVLLVGEHSPpEQRGYWASYPQAA----ASVGNVLATIVLLGSNFllsEEAFLAWGwrIAFWLsaVVVFIGYYIRkk 192
Cdd:cd17353 110 YITPVSTAVKWFP-DKRGLATGIVIAGfglgSLIFSPLIAYLINTVGV---PTTFLILG--IIFLI--IIVIGAFLIR-- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 193 vedapiFKEALKSQEENSHASTGLRTVITQYPKQLAVATAVRIGENAMYYL-------IIAFTLTYLTIFDAMTSQDVLL 265
Cdd:cd17353 180 ------DPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLnataglmLIGQAKPIGQEFAGLDAGIAAL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 266 IMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVwapFYFPLLNTGSfIIILFAVIFGLVvqSFMYGPEGALF--- 342
Cdd:cd17353 254 AVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGV---AMFLLPFIGS-VAVLFVLGVALI--GFCYGGGFALFpal 327
|
330 340 350
....*....|....*....|....*....|..
gi 505212428 343 -GELFPTR---ARYAGVSAAYQLGSILGGSLA 370
Cdd:cd17353 328 tADFFGTKnagTNYGLLYTAKGVGGLIGPIIA 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
258-404 |
6.11e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 6.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 258 MTSQDVLLIMFIANIVQFFSMIFGGYLSDQIGRRKTYLIGGVLALVwaPFYFPLLNTGSFIIILFAVIFGLVVqSFMYGP 337
Cdd:COG2223 37 LSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI--GLLLLALAVSYWLLLLLGLLLGIGG-GGSFAV 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505212428 338 EGALFGELFPTRaRYAGVSAAYQLGSILGGSLAPIIAVFLWNTFDSWIPIAIYLFTLLAFSIFSMVY 404
Cdd:COG2223 114 GIALVSKWFPPD-RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLF 179
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
243-410 |
9.18e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.75 E-value: 9.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 243 LIIAFTLtyLTIFDAMTSQDVLLI---MFIANIVQFFSmiFGGYLSDQIGRRKTYLIGGVLALVWAPFYFPLLNTGSFII 319
Cdd:PRK08633 30 ILIQNTL--IKAYDGSEQVILTAIvnaLFLLPFLLLSS--PAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWFWL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 320 iLFAVIFGLVVQSFMYGPegALFG---ELFPTRaRYAGVSAAYQLGSIL----GGSLAPIIAVFLWNTFDSWI--PIAIY 390
Cdd:PRK08633 106 -AFAVTFLLGAQSAIYSP--AKYGiipELVGKE-NLSRANGLLEAFTIVailaGTALFSFLFESVNGNTPSEIlgRIAPA 181
|
170 180
....*....|....*....|..
gi 505212428 391 LFTLLAFSIFSMV--YGVKETS 410
Cdd:PRK08633 182 GLVLLAVAVLGLIfaYRLPKVP 203
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
42-186 |
9.46e-03 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 38.06 E-value: 9.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505212428 42 LTYAIGFiarplggFVFGQLGDRFGRKKMLQVSLIMIGVATFLMGCLPD----FSVWGYAApialaaLRFIQGFAVGGEW 117
Cdd:cd17342 74 FSYAIGL-------FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEwlhfYNKYLYCI------LWVLNGLLQSTGW 140
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505212428 118 GGAVLLVGEHSPPEQRGYWASYPQAAASVGNVLATIVLlgsnfllseEAFLAWGWRIAFWLSAVVVFIG 186
Cdd:cd17342 141 PCVVAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLA---------SSVLDYGYEYAFLVTSSLLFAG 200
|
|
| |
