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Conserved domains on  [gi|505183027|ref|WP_015370129|]
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MULTISPECIES: DUF905 domain-containing protein [Enterobacteriaceae]

Protein Classification

DUF905 domain-containing protein( domain architecture ID 10532453)

uncharacterized DUF905 domain-containing protein similar to Escherichia coli YubL, YkfF and YpjL

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF905 pfam06006
Bacterial protein of unknown function (DUF905); This family consists of several short ...
 9-74 1.91e-35

Bacterial protein of unknown function (DUF905); This family consists of several short hypothetical Enterobacteria proteins of unknown function. Structural analysis of the surface features of the protein YvyC has revealed a single cluster of highly conserved residues on the surface. Additionally, these residues fall into two groups which lie within the two largest of the three cavities identified over the surface. The conclusion from this is that these two cavities with, Leu 58, Glu 75, Ile 82, and Glu 83 and Pro 86, conserved, are likely to be important for the molecular function and reflect the cavities found on the surface of the FlaG proteins in pfam03646.


:

Pssm-ID: 368702  Cd Length: 70  Bit Score: 114.59  E-value: 1.91e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505183027   9 LPPGSFTREQAEAVVAVYLSVAIEDDQGTHFRLVIRDSEGKLIWRAWSFEASAGEWLNRHIASHGI 74
Cdd:pfam06006  3 LPDGTFTREQAQAVAAQYQNVAIEDDQGTHFRLVVRDADGEMVWRAWNFEPGAGYWLNRYIRDYGI 68
 
Name Accession Description Interval E-value
DUF905 pfam06006
Bacterial protein of unknown function (DUF905); This family consists of several short ...
 9-74 1.91e-35

Bacterial protein of unknown function (DUF905); This family consists of several short hypothetical Enterobacteria proteins of unknown function. Structural analysis of the surface features of the protein YvyC has revealed a single cluster of highly conserved residues on the surface. Additionally, these residues fall into two groups which lie within the two largest of the three cavities identified over the surface. The conclusion from this is that these two cavities with, Leu 58, Glu 75, Ile 82, and Glu 83 and Pro 86, conserved, are likely to be important for the molecular function and reflect the cavities found on the surface of the FlaG proteins in pfam03646.


Pssm-ID: 368702  Cd Length: 70  Bit Score: 114.59  E-value: 1.91e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505183027   9 LPPGSFTREQAEAVVAVYLSVAIEDDQGTHFRLVIRDSEGKLIWRAWSFEASAGEWLNRHIASHGI 74
Cdd:pfam06006  3 LPDGTFTREQAQAVAAQYQNVAIEDDQGTHFRLVVRDADGEMVWRAWNFEPGAGYWLNRYIRDYGI 68
DotZ cd22644
Legionella pneumophila DotZ protein domain family; DotZ is a component of membrane-embedded T4 ...
 11-77 5.02e-03

Legionella pneumophila DotZ protein domain family; DotZ is a component of membrane-embedded T4 coupling complex (T4CC), which consists of the DotL ATPase, the DotM and DotN proteins,and DotY and DotZ. The DotLMNYZ hetero-pentamer plays an essential role in the recruitment and delivery of effectors to the Type IV secretion (T4S) machinery in Legionella pneumophila, a bacterial pathogen that utilizes a T4S system to inject effector proteins into human macrophages. DotZ is an integral part of the T4CC and plays a significant role in the translocation of effectors; this protein, along with DotZ, are unique to the Legionella genus.


Pssm-ID: 439349  Cd Length: 279  Bit Score: 33.70  E-value: 5.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505183027  11 PGSFTREQAEA----VVAvyLSVAIEDDQGTHFRLvIRDSEGKLI-----WRAwSFEASAGEwLNRHIASHGISHS 77
Cdd:cd22644   84 PGASTREDLEEerqkLVA--LGEEFHELELEHDKL-IAESQASLIklaaeWNK-ALESAAKK-IKSTLKSQGISKS 154
 
Name Accession Description Interval E-value
DUF905 pfam06006
Bacterial protein of unknown function (DUF905); This family consists of several short ...
 9-74 1.91e-35

Bacterial protein of unknown function (DUF905); This family consists of several short hypothetical Enterobacteria proteins of unknown function. Structural analysis of the surface features of the protein YvyC has revealed a single cluster of highly conserved residues on the surface. Additionally, these residues fall into two groups which lie within the two largest of the three cavities identified over the surface. The conclusion from this is that these two cavities with, Leu 58, Glu 75, Ile 82, and Glu 83 and Pro 86, conserved, are likely to be important for the molecular function and reflect the cavities found on the surface of the FlaG proteins in pfam03646.


Pssm-ID: 368702  Cd Length: 70  Bit Score: 114.59  E-value: 1.91e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505183027   9 LPPGSFTREQAEAVVAVYLSVAIEDDQGTHFRLVIRDSEGKLIWRAWSFEASAGEWLNRHIASHGI 74
Cdd:pfam06006  3 LPDGTFTREQAQAVAAQYQNVAIEDDQGTHFRLVVRDADGEMVWRAWNFEPGAGYWLNRYIRDYGI 68
DotZ cd22644
Legionella pneumophila DotZ protein domain family; DotZ is a component of membrane-embedded T4 ...
 11-77 5.02e-03

Legionella pneumophila DotZ protein domain family; DotZ is a component of membrane-embedded T4 coupling complex (T4CC), which consists of the DotL ATPase, the DotM and DotN proteins,and DotY and DotZ. The DotLMNYZ hetero-pentamer plays an essential role in the recruitment and delivery of effectors to the Type IV secretion (T4S) machinery in Legionella pneumophila, a bacterial pathogen that utilizes a T4S system to inject effector proteins into human macrophages. DotZ is an integral part of the T4CC and plays a significant role in the translocation of effectors; this protein, along with DotZ, are unique to the Legionella genus.


Pssm-ID: 439349  Cd Length: 279  Bit Score: 33.70  E-value: 5.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505183027  11 PGSFTREQAEA----VVAvyLSVAIEDDQGTHFRLvIRDSEGKLI-----WRAwSFEASAGEwLNRHIASHGISHS 77
Cdd:cd22644   84 PGASTREDLEEerqkLVA--LGEEFHELELEHDKL-IAESQASLIklaaeWNK-ALESAAKK-IKSTLKSQGISKS 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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