|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-860 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1586.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 81 AFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCP 160
Cdd:COG0495 81 AFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 161 NDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDNLDHWPDTVKTMQRNWIGRSEGVEISFDVNDYA 240
Cdd:COG0495 161 VDQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDGWPEKVKTMQRNWIGRSEGAEVDFPVEGSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 241 DKLTVYTTRPDTFMGCTYLAVAAGHPLAQQAAANNPAL--AAFIDECRNTKVAEADMATMEKKGVDTGFKAIHPLTGEAI 318
Cdd:COG0495 241 EKITVFTTRPDTLFGATFMVLAPEHPLVKELATPEQNAavAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEKI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 319 PVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSEQALTEKGVLFNSGEFSGLDYEAGFNA 398
Cdd:COG0495 321 PIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDDPDILEEAYTGDGVLINSGEFDGLDSEEAKEA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 399 IADKLAAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPEDQLPVILPEDVVMDGI-TSPIKADPEWAKTT 477
Cdd:COG0495 401 IIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDPTgGSPLARAPEWVNVT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 478 --VNGMPALRETDTFDTFMESSWYYARYTCPQYDKGMLDPNAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVN 555
Cdd:COG0495 481 cpKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLVS 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 556 SDEPAKQLLCQGMVLAdafyyVGENGErnwvspidatverdekgrivkafdpqgrelVYTGMSKMSKSKNNGIDPQVMVE 635
Cdd:COG0495 561 FDEPFKRLLTQGMVLE-----VGKDGV------------------------------VIGGIEKMSKSKGNVVDPDEIIE 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 636 RYGADTVRLFMMFASPAEMTLEWQESGVEGANRFLKRVWKLVYEHTSQGPavaLDVASLSEDQQALRRDVHKTIAKVTDD 715
Cdd:COG0495 606 KYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEALK---LDVADLSEADKELRRALHKTIKKVTED 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 716 IGrRQTFNTAIAAVMELMNKLAKAPQESEQDRALMREALLAVVRMLNPFTPHACFTLWQELGGEGDIDNAPWPVADESAM 795
Cdd:COG0495 683 IE-RLRFNTAIAALMELVNALYKAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEADEAAL 761
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505180625 796 VENTTLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLEGVTVRKVIYVPGKLLNLVVG 860
Cdd:COG0495 762 VEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
5-860 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1436.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 5 YRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGL 84
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 85 PAEGAAVKNNTAPAPWTYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQT 164
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 165 VLANEQVI-DGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDNLDHWPDTVKTMQRNWIGRSEGVEISFDVNDYADKL 243
Cdd:TIGR00396 161 VLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPESVKEMQRNWIGKSEGVEITFKIADHDEKI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 244 TVYTTRPDTFMGCTYLAVAAGHPLAQQAAANNPALAAFIDECRNTKVAEADMATMEKKGVDTGFKAIHPLTGEAIPVWAA 323
Cdd:TIGR00396 241 TVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPKVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIPIWVA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 324 NFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPdlSEQALTEKGVLFNSGEFSGLDYEAGFNAIADKL 403
Cdd:TIGR00396 321 NYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLS--LTAAYTEDGVLVNSGEFNGLNSSEARNAIIDML 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 404 AAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPEDQLPVILPEDVVMDGI-TSPIKADPEWAKTTVN--G 480
Cdd:TIGR00396 399 EKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDgGSPLSRIPEWVNVTCPscG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 481 MPALRETDTFDTFMESSWYYARYTCPQYDKGMLDPNAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPA 560
Cdd:TIGR00396 479 KPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPF 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 561 KQLLCQGMVLAdafYYVGENGErnwvSPIDATVERDEKGrivkaFDPQGRELVYTGMSKMSKSKNNGIDPQVMVERYGAD 640
Cdd:TIGR00396 559 KKLINQGMVLG---FYYPPNGK----VPADVLTERDEKG-----KDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGAD 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 641 TVRLFMMFASPAEMTLEWQESGVEGANRFLKRVWKLVYEHTSQGPAVALDVASLSEDQQALRRDVHKTIAKVTDDIGRRQ 720
Cdd:TIGR00396 627 ALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEKRE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 721 TFNTAIAAVMELMNKLAKAPQEseqdrALMREALLAVVRMLNPFTPHACFTLWQELG-GEGDIDNAPWPVADESAMVENT 799
Cdd:TIGR00396 707 SFNTAISAMMELLNKLYKAKKE-----ALMLEYLKGFVTVLSPFAPHLAEELWEKLGsEPFIIDNAKWPVVDETALVEDK 781
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505180625 800 TLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLEGVTVRKVIYVPGKLLNLVVG 860
Cdd:TIGR00396 782 TLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-860 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 883.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 9 EIESKVQLHWDENRTFEVTE--DESKEKYYCLSMLPYPSGR-LHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLP 85
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRTPDdvDTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 86 AEGAAVKNNTAPAPWTYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTV 165
Cdd:PLN02563 164 AEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTV 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 166 LANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDNLDhWPDTVKTMQRNWIGRSEGVEISFDVNDYA----- 240
Cdd:PLN02563 244 LANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLD-WPESIKEMQRNWIGRSEGAELDFSVLDGEgkerd 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 241 DKLTVYTTRPDTFMGCTYLAVAAGHPLAQQAAANNPALAafIDECRNTKVAEADM----ATMEKKGVDTGFKAIHPLTGE 316
Cdd:PLN02563 323 EKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEA--VEEYVDAASRKSDLerteLQKEKTGVFTGSYAINPATGE 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 317 AIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDlSEQALTEKGVLFNSGE----FSGLDY 392
Cdd:PLN02563 401 AIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDD-AEKAYTGEGVIVNSSSsgldINGLSS 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 393 EAGFNAIADKLAAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLED-GTVMPTPEDQLPVILPEdvvMDGIT------S 465
Cdd:PLN02563 480 KEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDsGEPVPVPESDLPLTLPE---LDDFTptgtgeP 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 466 PIKADPEWAKTT--VNGMPALRETDTFDTFMESSWYYARYTCPQYDKGMLDPNAANYWLPVDIYIGGIEHAIMHLLYFRF 543
Cdd:PLN02563 557 PLAKAVSWVNTVdpSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARF 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 544 FHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVS-PIDATVERDEKGRI------------VKAFDPQGR 610
Cdd:PLN02563 637 WHKVLYDIGVVSTKEPFQCLVNQGMILGEVEYTAFKDSDGEYVSaDTADRLGELQQEKIpeekviksgdsfVLKDDPSIR 716
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 611 elVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPAEMTLEWQESGVEGANRFLKRVWKLVY-EHTSQGPAVAL 689
Cdd:PLN02563 717 --LIARAHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVgAPLPDGSFRDG 794
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 690 DVASLSEDQQALRRDVHKTIAKVTDDI-GRRqtFNTAIAAVMELMN---KLAKAPqeseqdralmREALLAVVRMLNPFT 765
Cdd:PLN02563 795 TVVTDEEPSLEQLRLLHKCIAKVTEEIeSTR--FNTAISAMMEFTNaayKWDKVP----------REAIEPFVLLLSPYA 862
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 766 PHACFTLWQELGGEGDIDNAPWPVADESAMVENTTLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLEGVTVR 845
Cdd:PLN02563 863 PHLAEELWFRLGHSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIK 942
|
890
....*....|....*
gi 505180625 846 KVIYVPGKLLNLVVG 860
Cdd:PLN02563 943 KRIYVPGKILNVILK 957
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
34-658 |
1.89e-120 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 366.96 E-value: 1.89e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 34 KYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK 113
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 114 KLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCpndqtvlaneqvidgccwrcdtkverKEIPQWFI 193
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 194 KI--TAYADELLNdldnldhwpdtvktMQRNWIGRSEGVEISFdvndyadkltvyttrpdtfmgctylavaaghplaqqa 271
Cdd:cd00812 135 KYseTEWKEKLLK--------------DLEKLDGWPEEVRAMQ------------------------------------- 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 272 aannpalaafidecrntkvaeadmatmekkgvdtgfkaihpltgeaipvwaanfvlmeygtgavmavpghdqrdyefask 351
Cdd:cd00812 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 352 yglnikpvilaadgsepdlseqaltekgvlfnsgefsgldyeagfnaiadklaamgvgerkvnyrlRDW-GVSRQRYWGA 430
Cdd:cd00812 164 ------------------------------------------------------------------ENWiGCSRQRYWGT 177
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 431 PIPMvtledgtvmptpedqlpvilpedvvmdgitspikadpewakttvngmpalreTDTFDTFMESSWYYARYTCPQYDK 510
Cdd:cd00812 178 PIPW----------------------------------------------------TDTMESLSDSTWYYARYTDAHNLE 205
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 511 GML------DPNAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVnSDEPAKQLLCQGMVLAdafyyvgeNGErn 584
Cdd:cd00812 206 QPYegdlefDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLL--------EGE-- 274
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505180625 585 wvspidatverdekgrivkafdpqgrelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPAEMTLEW 658
Cdd:cd00812 275 ----------------------------------KMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
221-404 |
5.84e-104 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 319.11 E-value: 5.84e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 221 RNWIGRSEGVEISFDVNDYADKLTVYTTRPDTFMGCTYLAVAAGHPLAQQAAANNPALAAFIDECRNTKVAEADMATMEK 300
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAFIEECKNTSEIERTSETKEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 301 KGVDTGFKAIHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSE-PDLSEQALTEKG 379
Cdd:pfam13603 81 EGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGDLdLDIMTEAYTEEG 160
|
170 180
....*....|....*....|....*
gi 505180625 380 VLFNSGEFSGLDYEAGFNAIADKLA 404
Cdd:pfam13603 161 ILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-793 |
1.69e-93 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 313.15 E-value: 1.69e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 81 AFGLPAEGAAVKNNTAPAP----------------WTYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELY 144
Cdd:TIGR00422 81 HAGIATQVKVEKKLGAEGKtkhdlgreefrekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 145 KKGLVYKKTSAVNWCPNDQTVLANEQvidgccwrcdtkVERKEIPQ--WFIKitaYADEllndldnldhwpdtvktmqrn 222
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIE------------VEYKEVKGklYYIR---YPLA--------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 223 wigrsegveisfdvNDYADKLTVYTTRPDTFMGCTYLAVaagHPlaqqaaannpalaafiDECRNTkvaeadmaTMEKKg 302
Cdd:TIGR00422 205 --------------NGSKDYLVVATTRPETMFGDTAVAV---HP----------------EDERYK--------HLIGK- 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 303 vdtgfKAIHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLnikPVILaadgsepdlseqALTEKGVLF 382
Cdd:TIGR00422 243 -----KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNL---EFIN------------ILDEDGLLN 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 383 -NSGEFSGLDYEAGFNAIADKLAA-------------MGVGER------------------------------------- 411
Cdd:TIGR00422 303 eNAGKYQGLTRFEARKKIVEDLKEegllvkiephthnVGTCWRsgtvvepllskqwfvkvekladkaleaaeegeikfvp 382
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 412 ---KVNYR-----LRDWGVSRQRYWGAPIPMVTledgtvmptpedqlpvILPEDVVMDGITSPIKADPEWAKTTVNgmpA 483
Cdd:TIGR00422 383 krmEKRYLnwlrnIKDWCISRQLIWGHRIPVWY----------------CKECGEVYVAKEEPLPDDKTNTGPSVE---L 443
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 484 LRETDTFDTFMeSSWYYARYTC--PQYDKGMldpnaANYWlPVDIYIGGieHAImhlLYFRFFHKLMRdaGMVNSDE-PA 560
Cdd:TIGR00422 444 EQDTDVLDTWF-SSSLWPFSTLgwPDETKDL-----KKFY-PTDLLVTG--YDI---IFFWVARMIFR--SLALTGQvPF 509
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 561 KQLLCQGMVladafyyvgengernwvspidatveRDEKGRivkafdpqgrelvytgmsKMSKSKNNGIDPQVMVERYGAD 640
Cdd:TIGR00422 510 KEVYIHGLV-------------------------RDEQGR------------------KMSKSLGNVIDPLDVIEKYGAD 546
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 641 TVRLFMMFASPAEMTLEWQESGVEGANRFLKRVW---KLVYEHTSQGPAVA--LDVASLSeDQQALRRdVHKTIAKVTDD 715
Cdd:TIGR00422 547 ALRFTLASLVTPGDDINFDWKRVESARNFLNKLWnasRFVLMNLSDDLELSggEEKLSLA-DRWILSK-LNRTIKEVRKA 624
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 716 IGRRQtFNTAIAAVMEL-----------MNKLAKAPQESEQDRAL---MREALLAVVRMLNPFTPHACFTLWQELGGEGD 781
Cdd:TIGR00422 625 LDKYR-FAEAAKALYEFiwndfcdwyieLVKYRLYNGNEAEKKAArdtLYYVLDKALRLLHPFMPFITEEIWQHFKEGAD 703
|
890
....*....|...
gi 505180625 782 -IDNAPWPVADES 793
Cdd:TIGR00422 704 sIMLQSYPVVDAE 716
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-853 |
3.64e-81 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 278.23 E-value: 3.64e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 81 AFGLPAEgaaVK----NNTAPAP------------WTYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELY 144
Cdd:PRK13208 86 DNGLPTE---RKvekyYGIRKDDisreefielcreLTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 145 KKGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcDTKVERKEIPqwfikiTAYADellndldnldhwpdtvktmqrnwi 224
Cdd:PRK13208 163 KKGLIYRAEAPVLWCPRCETAIA------------QAEVEYRERE------GKLNY------------------------ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 225 grsegveISFDVNDyADKLTVYTTRPDTFMGCtyLAVAAgHPLaqqaaannpalaafiDEcRNTKVAeadmatmekkgvd 304
Cdd:PRK13208 201 -------IKFPVED-GEEIEIATTRPELLPAC--VAVVV-HPD---------------DE-RYKHLV------------- 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 305 tGFKAIHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVIlaadgsepdlseqalTEKGVLF-N 383
Cdd:PRK13208 241 -GKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIII---------------DEDGRMTeA 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 384 SGEFSGLDYEAGFNAIADKLAAMG-VGE-----RKVN-----------------------------------------YR 416
Cdd:PRK13208 305 AGKLAGLTIEEARKKIVEDLKSGGlLGKqepikHNVKfcercdtpleilvtrqwfikvldlkeellergkeinwypehMR 384
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 417 LR----------DWGVSRQRYWGAPIPM-VTLEDGTVMPTPEDQLPVilpeDvvmdgitsPIKADPEWAKTTVNGMPALR 485
Cdd:PRK13208 385 VRlenwieglnwDWCISRQRYFGTPIPVwYCKDCGHPILPDEEDLPV----D--------PTKDEPPGYKCPQCGSPGFE 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 486 -ETDTFDTFMESSwyyaryTCPQYDKG-MLDPNAANYWLPVDIYIGGieHAIMhllyfRF--FHKLMRdAGMVNSDEPAK 561
Cdd:PRK13208 453 gETDVMDTWATSS------ITPLIVTGwERDEDLFEKVFPMDLRPQG--HDII-----RTwlFYTILR-AYLLTGKLPWK 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 562 QLLCQGMVLadafyyvgengernwvspidatverDEKGRivkafdpqgrelvytgmsKMSKSKNNGIDPQVMVERYGADT 641
Cdd:PRK13208 519 NIMISGMVL-------------------------DPDGK------------------KMSKSKGNVVTPEELLEKYGADA 555
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 642 VRLFMMFASP-AEMTLEWQEsgVEGANRFLKRVW---KLVYehtSQGPAVALDVASLSE--DQQALRRdVHKTIAKVTDD 715
Cdd:PRK13208 556 VRYWAASARLgSDTPFDEKQ--VKIGRRLLTKLWnasRFVL---HFSADPEPDKAEVLEplDRWILAK-LAKVVEKATEA 629
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 716 IGRRQtFNTAIAAVM------------ELMNKLAKAPQESEQD---RALMREALLAVVRMLNPFTPHACFTLWQELGGeG 780
Cdd:PRK13208 630 LENYD-FAKALEEIEsffwhvfcddylELVKSRAYGEDEEEEQksaRYTLYTVLDTLLRLLAPFLPFITEEVWSWLYG-G 707
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 781 DIDNAPWPVADESAMVENTTLV---VVQVNGKVRG--------------KITVAVDATEEQVREragqehlVAKYLEGVT 843
Cdd:PRK13208 708 SVHRASWPEPDEELIDEEDEELgelAKEILSAVRKykseaglslnaplkKVEVYGPADLELLEA-------AEEDLKAAG 780
|
970
....*....|.
gi 505180625 844 -VRKVIYVPGK 853
Cdd:PRK13208 781 nIEELELVEGD 791
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-651 |
8.18e-60 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 214.58 E-value: 8.18e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 13 KVQLHWDENRTFEVTEDESKEK-YYCLSM-LPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAA 90
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKpSFTIHDgPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 91 VKNNTAPAP-----------------WTYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKT 153
Cdd:pfam00133 81 EKKLGIKEKktrhkygreefrekcreWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 154 SAVNWCPNDQTVLANeqvidgccwrcdTKVERKEI--PQWFikitayadellndldnldhwpdtvktmqrnwigrsegve 231
Cdd:pfam00133 161 KLVNWSPALNTALSN------------LEVEYKDVkgPSIH--------------------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 232 ISFDVNDYAD-KLTVYTTRPDTFMGCTYLAVaagHPlaqqaaannpaLAAFIDECRNTKVAEADMATMEKKGVDT----- 305
Cdd:pfam00133 190 VAFPLADDEGaSLVIWTTTPWTLPGNTAVAV---NP-----------EFDYVITGEGYILAEALLKSLYKKGTDKkiled 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 306 -------GFKAIHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIkPVILAADG----SEPDLSEQ- 373
Cdd:pfam00133 256 frgkeleGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEV-INPVDDDGtfteEAPDFQGVy 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 374 ----------ALTEKGVLFNSGEF---------SG--LDYEA--GFNAIADKLAAMGVGE-RKVNY-------------- 415
Cdd:pfam00133 335 rfdarkkiveLLTEKGLLLKIEPFthsypfcwrSGtpIIPRAtpQWFVRMDELADQALEAvEKVQFvpksgekryfnwla 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 416 RLRDWGVSRQRYWGAPIPMVTLEDGtvmptpedqlpvilpEDVVMDGITSPIKADPE--------WAKTTVNGMPAL--- 484
Cdd:pfam00133 415 NIQDWCISRQRWWGHPIPAWVSKDT---------------EEVVCRGELFELVAGRFeeegsikwLHREAKDKLGYGkgt 479
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 485 --RETDTFDTFMES-SWYYARYTCPQYDKGMLDPnaanyWLPVDIYIGGIEhaimhLLYFRFFHKLMRDAGMVNSdEPAK 561
Cdd:pfam00133 480 leQDEDVLDTWFSSgSWPFSTLGWPFVNTEEFKK-----FFPADMLLEGSD-----QTRGWFYRMIMLSTALTGS-VPFK 548
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 562 QLLCQGMVladafyyvgengernwvspidatveRDEKGRivkafdpqgrelvytgmsKMSKSKNNGIDPQVMVERYGADT 641
Cdd:pfam00133 549 NVLVHGLV-------------------------RDEQGR------------------KMSKSLGNVIDPLDVIDKYGADA 585
|
730
....*....|
gi 505180625 642 VRLFMMFASP 651
Cdd:pfam00133 586 LRLWLANSDY 595
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
3-794 |
5.59e-57 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 210.69 E-value: 5.59e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 3 EQYRPEEIESKVQLHWDENRTFEVTED--ESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEKVKKlnKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 81 AFGLPAEGAAVKNNtaPAPWTYD-------------------NIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFT 141
Cdd:TIGR00392 84 THGLPIEHKVEKKL--GISGKKEissleieefrekcrefalkQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 142 ELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRcdtkveRKEIPQWFIKITAYADELLNDLDNLDhwpdtvktmqr 221
Cdd:TIGR00392 162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENYK------DVKDPSIYVKFPVKKDKKTYLKVKLS----------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 222 nwigrsegveisfdvndyadKLTVYTTRPDTFMGCTYLAVaagHP-LAQQAAANNPALAAFIdecrntkVAEADMAT-ME 299
Cdd:TIGR00392 225 --------------------SLLIWTTTPWTLPSNLAIAV---HPdFEYALVQDNTKVEYFI-------LAKKLVEKlYN 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 300 KKGVD------------TGFKAIHPLTGEAIP-------VWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNI-KPV 359
Cdd:TIGR00392 275 KAGSDyeiiktfkgsdlEGLEYEHPLYDFVSQlkegapvVIGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVlSPV 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 360 ------------------------ILAADgsepDLSEQALTEKGVLFNSGEFS---GLDY-----------EAGF---NA 398
Cdd:TIGR00392 355 dekgvytegvndfqgrfvkdadkdIIKAN----KIIIEQLKDKGLLLKAEKIThsyPHCWrtktpviyratEQWFiktKD 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 399 IADK-LAAMGvgerKVNY-------RL-------RDWGVSRQRYWGAPIPMVTLEDGtvmptpeDQLPVI-----LPEDV 458
Cdd:TIGR00392 431 IKDQmLEQIK----KVNWvpewgegRFgnwlenrPDWCISRQRYWGIPIPIWYCEDT-------GEPIVVgsieeLIELI 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 459 VMDGITSPIKADP----EWAKTT-VNGMPALRETDTFDTFMES-SWYYA----RYTCPQYDKgmldpnaanyWLPVDIYI 528
Cdd:TIGR00392 500 ELKGIDAWFEDLHrdflDKITLKsGDGGEYRRVPDVLDVWFDSgSMPYAsihyPFENEKFKE----------VFPADFIL 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 529 GGIEHaimhllYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLadafyyvgengernwvspidatverDEKGRivkafdpq 608
Cdd:TIGR00392 570 EGSDQ------TRGWFYSSLAIGTALFGQAPYKNVITHGFTL-------------------------DEKGR-------- 610
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 609 grelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPAEmTLEWQESGVEGANRFLKRVWKLVYE--------H 680
Cdd:TIGR00392 611 ----------KMSKSLGNVVDPLKVINKYGADILRLYVASSDPWE-DLRFSDEILKQVVEKYRKIRWNTYRflltyanlD 679
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 681 TSQGPAVALDVASLS-EDQQALRRdVHKTIAKVTDDIGRRQtFNTAIAAVMELMNK--------LAKAPQESEQDRALMR 751
Cdd:TIGR00392 680 KFDPLFNSVAVEKFPeEDRWILSR-LNSLVEEVNEALEKYN-FHKVLRALQDFIVEelsnwyirIIRDRLYCEAKDNDKR 757
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 505180625 752 -------EALLAVVRMLNPFTPHACFTLWQELGGEGD---IDNAPWPVADESA 794
Cdd:TIGR00392 758 aaqttlyYALLTLVRLLAPFLPHTAEEIYQNLPGGEEeesVHLNLWPEVDEEF 810
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-794 |
8.29e-57 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 210.35 E-value: 8.29e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 1 MQEQYRPEEIESKVQLHWDENRTFEvTEDESKEKYyCLsMLPYP--SGRLHMGHVRNYTIGDVIARYQRMLGKNVL-QPi 77
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFK-PDDNSKKPF-SI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwLP- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 78 GWDAFG----------LPAEG------------AAVKNntapapWT---YDNIaymKNQLKKLGFGYDWSREIATCTPEY 132
Cdd:PRK05729 81 GTDHAGiatqmvverqLAAEGksrhdlgrekflEKVWE------WKeesGGTI---TNQLRRLGASCDWSRERFTMDEGL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 133 YRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtkvERKEIPQ--WFIKitaYADEllndldnld 210
Cdd:PRK05729 152 SKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV------------EYKEVKGklWHIR---YPLA--------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 211 hwpdtvktmqrnwigrsegveisfDVNDYadkLTVYTTRPDTFMGCTYLAVaagHPLaqqaaannpalaafiDEcRNTKV 290
Cdd:PRK05729 208 ------------------------DGSDY---LVVATTRPETMLGDTAVAV---NPE---------------DE-RYKHL 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 291 AeadmatmekkgvdtGFKAIHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLnikPVIlaadgsepdl 370
Cdd:PRK05729 242 I--------------GKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL---PMI---------- 294
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 371 seQALTEKGVLF-NSGEFSGLD-YEAGfNAIADKLAAMGV-------------GER---------------KV------- 413
Cdd:PRK05729 295 --NIMDEDGTINeNPGEYQGLDrFEAR-KAIVADLEELGLlvkiephthsvghSDRsgvviepylsdqwfvKMkplakpa 371
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 414 ------------------NYR-----LRDWGVSRQRYWGAPIPMVTLEDGTVMPTPEDqlpvilPEDVVMDGITspikad 470
Cdd:PRK05729 372 leavengeikfvperwekTYFhwmenIQDWCISRQLWWGHRIPAWYDEDGEVYVGREE------PEAREKALLT------ 439
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 471 pewakttvngmpalRETDTFDT-FmeSSWYYARYTcpqydkgMLDPNAA---NYWLPVDIYIGGieHAIMhllyfrFFHk 546
Cdd:PRK05729 440 --------------QDEDVLDTwF--SSALWPFST-------LGWPEKTedlKRFYPTSVLVTG--FDII------FFW- 487
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 547 lmrDAGMVNS------DEPAKQLLCQGMVladafyyvgengernwvspidatveRDEKGRivkafdpqgrelvytgmsKM 620
Cdd:PRK05729 488 ---VARMIMMglhftgQVPFKDVYIHGLV-------------------------RDEQGR------------------KM 521
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 621 SKSKNNGIDPQVMVERYGADTVRLFMMFASPAEMTLEWQESGVEGANRFLKRVW---KLVYEHTS-QGPAVALDVASLS- 695
Cdd:PRK05729 522 SKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWnasRFVLMNLEgADVGELPDPEELSl 601
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 696 EDQQALRRdVHKTIAKVTDDIGRRQtFNTAIAAVMEL-----------MNKLAKAPQESEQDRALMREALLAVVRMLNPF 764
Cdd:PRK05729 602 ADRWILSR-LNRTVAEVTEALDKYR-FDEAARALYEFiwnefcdwyleLAKPVLQEAAKRATRATLAYVLEQILRLLHPF 679
|
890 900 910
....*....|....*....|....*....|...
gi 505180625 765 TPHACFTLWQELGGEGDIDN---APWPVADESA 794
Cdd:PRK05729 680 MPFITEELWQKLAPLGIEESimlAPWPEADEAI 712
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-795 |
9.03e-54 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 201.43 E-value: 9.03e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYyCLsMLPYP--SGRLHMGHVRNYTIGDVIARYQRMLGKNVL-QPi 77
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPF-TI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwQP- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 78 GWDAFG----------LPAEG------------AAVknntapapW----TYDNIayMKNQLKKLGFGYDWSREIATCTPE 131
Cdd:COG0525 80 GTDHAGiatqavverqLAEEGksrhdlgrekflERV--------WewkeESGGT--ITNQLRRLGASCDWSRERFTMDEG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 132 YYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtkvERKEIPQ--WFIKitaY--ADEllndld 207
Cdd:COG0525 150 LSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV------------EHEEVKGhlWHIR---YplADG------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 208 nldhwpdtvktmqrnwigrsegveisfdvndyADKLTVYTTRPDTFMGCTYLAVaagHPLaqqaaannpalaafiDEcRN 287
Cdd:COG0525 209 --------------------------------SGYIVVATTRPETMLGDTAVAV---HPE---------------DE-RY 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 288 TKVAeadmatmekkgvdtGFKAIHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIkPVILAADGSe 367
Cdd:COG0525 238 KHLI--------------GKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPM-INILDEDGT- 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 368 pdlseqaLTEKGvlfnsGEFSGLD-YEAGfNAIADKLAAMG-----------VG-------------------------- 409
Cdd:COG0525 302 -------INENA-----GKYRGLDrFEAR-KAIVADLEELGllvkvephkhsVGhsdrsgtviepylsdqwfvkmkplak 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 410 ---------------ERKVN-YR-----LRDWGVSRQRYWGAPIPMVTLEDGTVMptpedqlpvilpedVVMDGITSPIK 468
Cdd:COG0525 369 paieavedgeikfvpERWEKtYFhwmenIRDWCISRQLWWGHRIPAWYCPDGEVY--------------VARTEPEACAK 434
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 469 ADPEwakttvngmpAL-RETDTFDT-FmeSSWyyarytcpqydkgmL---------DPNAA-NYWLPVDIYIGG--Ieha 534
Cdd:COG0525 435 AGSV----------NLtQDEDVLDTwF--SSA--------------LwpfstlgwpEKTEDlKYFYPTSVLVTGfdI--- 485
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 535 imhlLYF---RffhklMRDAGMVNSDE-PAKQLLCQGMVladafyyvgengernwvspidatveRDEKGRivkafdpqgr 610
Cdd:COG0525 486 ----IFFwvaR-----MIMMGLHFTGEvPFKDVYIHGLV-------------------------RDEQGR---------- 521
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 611 elvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPAEMTLEWQESGVEGANRFLKRVW---KLVYEHT-SQGPA 686
Cdd:COG0525 522 --------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWnasRFVLMNLeGFDPG 593
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 687 VALDVASLS-EDQQALRRdVHKTIAKVTDDIGRRQtFNTAIAAVMELM-NK-------LAKAP--QESEQDRALMREALL 755
Cdd:COG0525 594 LDPDPEELSlADRWILSR-LNKTIAEVTEALEKYR-FDEAAQALYDFVwNEfcdwyleLAKPRlyGGDEAAKRETRATLV 671
|
890 900 910 920
....*....|....*....|....*....|....*....|....*..
gi 505180625 756 AV----VRMLNPFTPHACFTLWQELGGEGD---IDNAPWPVADESAM 795
Cdd:COG0525 672 YVleqiLRLLHPFMPFITEEIWQKLPPRKEgesIMLAPWPEADEELI 718
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-793 |
2.05e-53 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 200.48 E-value: 2.05e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 48 LHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAA--VKNNTAPAPWTY-----------------DNIA-Y 107
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILGIAerIARGDPETIELYkslygipeeelekfkdpEYIVeY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 108 ----MKNQLKKLGFGYDWSREIATCTPEYyrweQKF----FTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGccwrc 179
Cdd:PRK12300 81 fseeAKEDMKRIGYSIDWRREFTTTDPEY----SKFiewqFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDG----- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 180 dtkvERKEIPQW-FIKITAYAD----------ELLNDLDNLdhW--PDT----VKTMQRNWIgrsegveISFDVndyADK 242
Cdd:PRK12300 152 ----EEPEIVEYtLIKFEESEDlilpaatlrpETIFGVTNL--WvnPDAtyvkAEVDGEKWI-------VSKEA---AEK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 243 LTvyttrpdtfmgctylavaaghplaqqaaannpalaafiDECRNTKVAEadmatmEKKGVD-TGFKAIHPLTGEAIPVW 321
Cdd:PRK12300 216 LS--------------------------------------FQDRDVEIIE------EIKGSElIGKKVKNPVTGKEVPIL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 322 AANFVLMEYGTGAVMAVPGHDQRDY--------EFASKYGLNIKPVI--------LAAD---------GSEPDLsEQALT 376
Cdd:PRK12300 252 PADFVDPDNGTGVVMSVPAHAPYDYvalrdlkkNKELLDVIEPIPLIevegygefPAKEvveklgiksQEDPEL-EEATK 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 377 E-------KGVLF-NSGEFSGLDYEAGFNAIADKLAAMGVG-------ERKV---------------------------- 413
Cdd:PRK12300 331 EvyraefhKGVLKeNTGEYAGKPVREAREKITKDLIEKGIAdimyefsNRPVycrcgtecvvkvvkdqwfidysdpewke 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 414 --------------NYR---------LRDWGVSRQRYWGAPIP------MVTLEDGTVMP--------------TPEDql 450
Cdd:PRK12300 411 lahkaldnmeiipeEYRkefentidwLKDRACARRRGLGTRLPwdeewiIESLSDSTIYMayytiahkireygiKPEQ-- 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 451 pvILPE--DVVMDGITSP--IKADPEWAKTTVNGMpalREtdTFdtfmesswyyarytcpqydkgmldpnaaNYWLPVDI 526
Cdd:PRK12300 489 --LTPEffDYVFLGKGDPeeVSKKTGIPKEILEEM---RE--EF----------------------------LYWYPVDW 533
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 527 YIGGIEHAIMHLLYFRFFHKLMRDagmvnsdepaKQLLCQGMVLadafyyvgeNGernWVspidaTVErdekGRivkafd 606
Cdd:PRK12300 534 RHSGKDLIPNHLTFFIFNHVAIFP----------EEKWPRGIVV---------NG---FV-----LLE----GK------ 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 607 pqgrelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMfaSPAEMT--LEWQESGVEGANRFLKRVWKL---VYEHT 681
Cdd:PRK12300 577 ------------KMSKSKGNVIPLRKAIEEYGADVVRLYLT--SSAELLqdADWREKEVESVRRQLERFYELakeLIEIG 642
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 682 SQGPAVALDVASLSEdqqalrrdVHKTIAKVTDDIGRRQTFNTAIAAVMELMNKLAKAPQESEQD-RALMREALLAVVRM 760
Cdd:PRK12300 643 GEEELRFIDKWLLSR--------LNRIIKETTEAMESFQTRDAVQEAFYELLNDLRWYLRRVGEAnNKVLREVLEIWIRL 714
|
890 900 910
....*....|....*....|....*....|...
gi 505180625 761 LNPFTPHACFTLWQELGGEGDIDNAPWPVADES 793
Cdd:PRK12300 715 LAPFTPHLAEELWHKLGGEGFVSLEKWPEPDES 747
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
658-776 |
3.19e-49 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 169.32 E-value: 3.19e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 658 WQESGVEGANRFLKRVWKLVYEHTSQGPAVALDvASLSEDQQALRRDVHKTIAKVTDDIGRRQtFNTAIAAVMELMNKLA 737
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAA-AELSEEDKELRRKLHKTIKKVTEDIERLR-FNTAIAALMELVNALY 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 505180625 738 KAPQESEQDRALMREALLAVVRMLNPFTPHACFTLWQEL 776
Cdd:cd07958 79 KYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
42-651 |
4.42e-48 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 175.51 E-value: 4.42e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAP----------------WTYDNI 105
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKtrhdlgreeflekcweWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 106 AYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgcCWRCDTKVER 185
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIEP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 186 KEIPQWFIKITAYADELLndldnldhwpdtvktmqrnwigrsegveisfdvndyadkltvyttrpdtfmgctylavaagh 265
Cdd:cd00817 166 LLKPQWFVKVKDLAKKAL-------------------------------------------------------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 266 plaqqaaannpalaafidecrntkvaeadmatmekkgvdtgfkaihpltgeaipvwaanfvlmeygtgavmavpghdqrd 345
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 346 yEFASKYGLNIKPvilaadgsepdlseqaltekgvlfnsgEFSGLDYEAGFNAIadklaamgvgerkvnyrlRDWGVSRQ 425
Cdd:cd00817 184 -EAVKEGDIKFVP---------------------------ERMEKRYENWLENI------------------RDWCISRQ 217
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 426 RYWGAPIPMVTLED-GTVMPTPEDQLPVILPEDVVMDGitspiKADPEWAkttvngmpalRETDTFDTFMeSSWYYARYT 504
Cdd:cd00817 218 LWWGHRIPAWYCKDgGHWVVAREEDEAIDKAAPEACVP-----CGGEELK----------QDEDVLDTWF-SSSLWPFST 281
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 505 CPQYDkgmlDPNAANYWLPVDIYIGGieHAImhlLYFRFFHKLMRdaGMVNSDE-PAKQLLCQGMVladafyyvgenger 583
Cdd:cd00817 282 LGWPE----ETKDLKKFYPTSLLVTG--HDI---IFFWVARMIMR--GLKLTGKlPFKEVYLHGLV-------------- 336
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505180625 584 nwvspidatveRDEKGRivkafdpqgrelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASP 651
Cdd:cd00817 337 -----------RDEDGR------------------KMSKSLGNVIDPLDVIDGYGADALRFTLASAAT 375
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
4-794 |
8.72e-46 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 177.58 E-value: 8.72e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 4 QYRPEEIESKVQLHWDENRTFE--VTEDESKEKYYclsmL----PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVL-QP 76
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEksREARAGRPKFV----LhdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPyVP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 77 iGWDAFGLPAEGAAVKNN--TAPAPWTYD--------------NIAYMKNQLKKLGFGYDWSREIATCTPEYYR---WEq 137
Cdd:COG0060 91 -GWDCHGLPIELKVEKELgiKKKDIEKVGiaefrekcreyalkYVDEQREDFKRLGVWGDWDNPYLTMDPEYEEsiwWA- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 138 kfFTELYKKGLVYKKTSAVNWCPNDQTVLAN-EqvidgccwrcdtkVERKEI--PQWFIKITAYADELLNDLDNLdhwpd 214
Cdd:COG0060 169 --LKKLYEKGLLYKGLKPVPWCPRCGTALAEaE-------------VEYKDVtsPSIYVKFPVKDEKALLLLEDA----- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 215 tvktmqrnwigrsegveisfdvndyadKLTVYTTRPDTfmgctyL----AVAAgHPlaqqaaannpalaaFID----ECR 286
Cdd:COG0060 229 ---------------------------YLVIWTTTPWT------LpanlAVAV-HP--------------DIDyvlvEVT 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 287 NTK---VAEADM-ATMEKKGVDT-------------GFKAIHPLTGE-----AIPVWAANFVLMEYGTGAV-MAvPGHDQ 343
Cdd:COG0060 261 GGErliLAEALVeAVLKELGIEDyevlatfkgaeleGLRYEHPFYYVvgydrAHPVILGDYVTTEDGTGIVhTA-PGHGE 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 344 RDYEFASKYGLNI-KPV-----------------ILAADgsePDLSEqALTEKGVLFNSGE------------------- 386
Cdd:COG0060 340 DDFEVGKKYGLPVlNPVdddgrfteeaplfaglfVKDAN---PAIIE-DLKERGALLAREKithsyphcwrcktpliyra 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 387 ----FSGLDyeagfnAIADK-LAAMgvgeRKVNY-------RL-------RDWGVSRQRYWGAPIPMVTLED-GTVMPTP 446
Cdd:COG0060 416 tpqwFISMD------KLRDRaLEAI----EKVNWipewgegRFgnmlenrPDWCISRQRYWGVPIPIWVCEDcGELHRTE 485
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 447 EdqlpVI--LPEDVVMDGITSPIKAD------PEWAKTTVNGMPALRETDTFDTFMES--SWYyarytcpqydkGMLDpN 516
Cdd:COG0060 486 E----VIgsVAELLEEEGADAWFELDlhrpflDETLKCPKCGGTMRRVPDVLDVWFDSgsMHF-----------AVLE-N 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 517 AANYWLPVDIYIGGI-EHaimhllyfR-FFHKLMRDAGMVNSDEPAKQLLCQGMVLadafyyvgengernwvspidatve 594
Cdd:COG0060 550 REELHFPADFYLEGSdQT--------RgWFYSSLLTSTALFGRAPYKNVLTHGFVL------------------------ 597
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 595 rDEKGRivkafdpqgrelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASP-AEMTLEWQesGVEGANRFLKRV 673
Cdd:COG0060 598 -DEDGR------------------KMSKSLGNVVDPQEVIDKYGADILRLWVASSDYwGDLRFSDE--ILKEVRDVYRRL 656
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 674 WKLV---------YEHTsqgpAVALDVASLSE-DQQALRRdVHKTIAKVTDDIGRRQtFNTAIAAVMELMN--------K 735
Cdd:COG0060 657 RNTYrfllanlddFDPA----EDAVPYEDLPElDRWILSR-LNELIKEVTEAYDNYD-FHRAYRALHNFCVedlsnwylD 730
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505180625 736 LAK----APQESEQDR----ALMREALLAVVRMLNPFTPHACFTLWQELGGEGD--IDNAPWPVADESA 794
Cdd:COG0060 731 ISKdrlyTEAADSLDRraaqTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAEesVHLADWPEVDEEL 799
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
5-816 |
4.63e-36 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 147.45 E-value: 4.63e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 5 YRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLsMLPYP--SGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAF 82
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEHDRTRPPFSI-VLPPPnvTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 83 GLP-----------AEGAAVKNNTAPA------PWTYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYK 145
Cdd:PRK14900 98 GIAtqmivekelkkTEKKSRHDLGREAflervwAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 146 KGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcDTKVERKEipqwfikitAYADELlndldnldhwpdtvktmqrnWig 225
Cdd:PRK14900 178 EGLIYREKKLINWCPDCRTALS------------DLEVEHEE---------AHQGEL--------------------W-- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 226 rsegvEISFDVNDYADKLTVYTTRPDTFMGCTYLAVaagHPLAqqaaannpalaafidecrntkvaeadmatmEKKGVDT 305
Cdd:PRK14900 215 -----SFAYPLADGSGEIVVATTRPETMLGDTAVAV---HPLD------------------------------PRYMALH 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 306 GFKAIHPLTGEAIPVWA-ANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVIlaadGSEPDLSEQAltekgvlfns 384
Cdd:PRK14900 257 GKKVRHPITGRTFPIVAdAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVI----GPDGRMTAEA---------- 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 385 GEFSGLD-YEAGFNAIADkLAAMGVGERKVNYRL---------------------------------------------- 417
Cdd:PRK14900 323 GPLAGLDrFEARKEVKRL-LAEQGLDRGAKPHVLplgrcqrsatilepllsdqwyvrieplarpaieaveqgrtrfipeq 401
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 418 ------------RDWGVSRQRYWGAPIPMVTLEDGTVM---PTPED-----QLPVILPEDVVMDGITSPIkadpeWAKTT 477
Cdd:PRK14900 402 wtntymawmrniHDWCISRQLWWGHQIPAWYCPDGHVTvarETPEAcstcgKAELRQDEDVLDTWFSSGL-----WPFST 476
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 478 VnGMPalRETDTFDTFMESSWYYARYtcpqydkgmldpnaanywlpvDIYIGGIEHAIMHLLYFRffhklmrdagmvnSD 557
Cdd:PRK14900 477 M-GWP--EQTDTLRTFYPTSVMETGH---------------------DIIFFWVARMMMMGLHFM-------------GE 519
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 558 EPAKQLLCQGMVladafyyvgengernwvspidatveRDEKGRivkafdpqgrelvytgmsKMSKSKNNGIDPQVMVERY 637
Cdd:PRK14900 520 VPFRTVYLHPMV-------------------------RDEKGQ------------------KMSKTKGNVIDPLVITEQY 556
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 638 GADTVRLFMMFASPAEMTLEWQESGVEGANRFLKRVWKLV---------YEHTSQGPA-VALDVAS---LSEdqqaLRRD 704
Cdd:PRK14900 557 GADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWNASrfalmnlsgYQERGEDPArLARTPADrwiLAR----LQRA 632
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 705 VHKTIAKVtDDIGRRQTFNTAIAAVM-ELMN---KLAKA------PQESEQDRALMREALLAVVRMLNPFTPHACFTLWQ 774
Cdd:PRK14900 633 VNETVEAL-EAFRFNDAANAVYAFVWhELCDwyiELAKEalasedPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWH 711
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 505180625 775 EL----GGEGDIDN---APWP---VADESAMVE-NTTLVVVQVNGKVRGKITV 816
Cdd:PRK14900 712 VLraqvGASAWADSvlaAEYPrkgEADEAAEAAfRPVLGIIDAVRNIRGEMGI 764
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
34-224 |
2.81e-34 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 133.70 E-value: 2.81e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 34 KYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAA-------------VKNNTAPAPW 100
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 101 TYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKktsavnwcpndqtvlaneqvidgccwrcD 180
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYR----------------------------G 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 505180625 181 TKVERKEiPQWFIKITAYADELLNDLDNLDHWPDTVKTMQRNWI 224
Cdd:cd00668 133 THPVRIT-EQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWL 175
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-449 |
1.68e-33 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 138.98 E-value: 1.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDE----SKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQP 76
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAkslnSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 77 IGWDAFGLpAEGAAV------KNNtaPAPWTYDNIAYMK--------------NQLKKLGFGYDWSREIATCTPEYYRWE 136
Cdd:PTZ00419 104 PGTDHAGI-ATQVVVekklmkEEN--KTRHDLGREEFLKkvwewkdkhgnnicNQLRRLGSSLDWSREVFTMDEQRSKAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 137 QKFFTELYKKGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcDTKVERKEIPQ-WFIKITAYadELLNDLDNLDHwpdt 215
Cdd:PTZ00419 181 KEAFVRLYEDGLIYRDTRLVNWCCYLKTAIS------------DIEVEFEEIEKpTKITIPGY--DKKVEVGVLWH---- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 216 vktmqrnwigrsegveISFDVNDYAD-KLTVYTTRPDTFMGCTYLAVaagHPLaqqaaannpalaafiDEcRNTKVaead 294
Cdd:PTZ00419 243 ----------------FAYPLEDSGQeEIVVATTRIETMLGDVAVAV---HPK---------------DE-RYKKL---- 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 295 matmekkgvdTGFKAIHPLT-GEAIPVWA-ANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKpVILAADGSepdlse 372
Cdd:PTZ00419 284 ----------HGKELIHPFIpDRKIPIIAdDELVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFI-NIFTLDGK------ 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 373 qaLTEkgvlfNSGEFSGLD-YEAGFnAIADKLAAMGVGERK----------------VNYRL------------------ 417
Cdd:PTZ00419 347 --INE-----NGGEFAGMHrFDCRR-KIEEELKEMGLLRDKvpnpmrlprcsrsgdiVEPMLipqwyvnckdmakravea 418
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 505180625 418 ------------------------RDWGVSRQRYWGAPIP--MVTLEDGTVMPTPEDQ 449
Cdd:PTZ00419 419 vrngelkiipsshenvwyhwleniQDWCISRQLWWGHRIPayRVISKGPETDPSDEEP 476
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
34-246 |
1.19e-29 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 120.33 E-value: 1.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 34 KYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK 113
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 114 KLGFGYDwsREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcdtkvERKEIPQWFI 193
Cdd:cd00814 81 WLNISFD--YFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYFF 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505180625 194 KITAYADELLNDLDNLDH--WPDTVKTMQRNWIgrSEGVE---ISFDVNDY------ADKLTVY 246
Cdd:cd00814 143 RLSKFQDRLLEWLEKNPDfiWPENARNEVLSWL--KEGLKdlsITRDLFDWgipvplDPGKVIY 204
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
35-246 |
3.08e-29 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 120.86 E-value: 3.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 35 YYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKK 114
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 115 LGFGYDWSreIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGC------------------- 175
Cdd:pfam09334 81 FNISFDDY--GRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEGTCphcgsedargdqcencgrh 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 176 ----------CWRCDTKVERKEIPQWFIKITAYADELLNDLD-NLDHWPDTVKTMQRNWIgrSEGVE---ISFDvNDY-- 239
Cdd:pfam09334 159 leptelinpkCVICGTTPEVKETEHYFFDLSKFQDKLREWIEeNNPEWPENVKNMVLEWL--KEGLKdraISRD-LDWgi 235
|
250
....*....|.
gi 505180625 240 ----ADKLTVY 246
Cdd:pfam09334 236 pvpgAEGKVFY 246
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
33-224 |
7.02e-29 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 122.14 E-value: 7.02e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 33 EKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQL 112
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 113 KKLGFGYD-WSReiaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQT--------------------------- 164
Cdd:COG0143 81 EKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERflpdryvegtcpkcgaedaygdqcenc 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505180625 165 --VLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDNLDHWPDTVKTMQRNWI 224
Cdd:COG0143 158 gaTLEPTELINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVRNEVLSWL 219
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-644 |
1.69e-28 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 122.96 E-value: 1.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 11 ESKVQLHWDENRTFE-VTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAE-- 87
Cdd:PLN02843 9 EPEIQKLWEENQVYKrVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIElk 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 88 -----GAAVKNNTAP-------APWTYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTSA 155
Cdd:PLN02843 89 vlqslDQEARKELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 156 VNWCPNDQTVLANEQVidgccwrcdtkverkEIPQWFIKITAYA---------------DELLNDLdNLDHWPDTVKTMQ 220
Cdd:PLN02843 169 VHWSPSSRTALAEAEL---------------EYPEGHVSKSIYVafpvvspsetspeelEEFLPGL-SLAIWTTTPWTMP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 221 RNwigrsegveISFDVNdyaDKLtvyttrpdtfmgcTYLAVAAGHPLAQQAAANNPALAAFIDECRNTK-----VAEADM 295
Cdd:PLN02843 233 AN---------AAVAVN---DKL-------------QYSVVEVQSFSEDESTSGGNKKKRPGNVLKEQQklfliVATDLV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 296 ATMEKK------------GVD-TGFKAIHPLTGEAIPVWAA-NFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNI-KPV- 359
Cdd:PLN02843 288 PALEAKwgvklvvlktfpGSDlEGCRYIHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLlSPVd 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 360 ------ILAADGSEPD-LSE------QALTEKGVL---------------------FNSGE--FSGLDyeaGFNAIAdkL 403
Cdd:PLN02843 368 dagkftEEAGQFSGLSvLGEgnaavvEALDEAGSLlmeeayghkypydwrtkkptiFRATEqwFASVE---GFRQAA--L 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 404 AAMgvgeRKVNY-------RLR-------DWGVSRQRYWGAPIPMVTLEDgtvmpTPEdqlpVILPEDVVmDGITSPIK- 468
Cdd:PLN02843 443 DAI----DKVKWipaqgenRIRamvsgrsDWCISRQRTWGVPIPVFYHVE-----TKE----PLMNEETI-AHVKSIVAq 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 469 --ADPEWAKTTVNGMPA---------LRETDTFDTFMES--SWyyarytcpqydKGMLDPNAANYWlPVDIYIGGIEHai 535
Cdd:PLN02843 509 kgSDAWWYMDVEDLLPEkyrdkasdyEKGTDTMDVWFDSgsSW-----------AGVLGSREGLSY-PADLYLEGSDQ-- 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 536 mHLLYFRffHKLMRDAGmVNSDEPAKQLLCQGMVLadafyyvgengernwvspidatverDEKGRivkafdpqgrelvyt 615
Cdd:PLN02843 575 -HRGWFQ--SSLLTSVA-TKGKAPYKSVLTHGFVL-------------------------DEKGF--------------- 610
|
730 740 750
....*....|....*....|....*....|....*...
gi 505180625 616 gmsKMSKSKNNGIDPQVMVE---------RYGADTVRL 644
Cdd:PLN02843 611 ---KMSKSLGNVVDPRLVIEggknqkqepAYGADVLRL 645
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
33-204 |
1.93e-26 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 114.21 E-value: 1.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 33 EKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQL 112
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 113 KKLGFGYD-WSReiaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDG--CCWRCDTKVERKEIP 189
Cdd:PRK11893 81 EALNISYDdFIR---TTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDgyRCPPTGAPVEWVEEE 157
|
170
....*....|....*
gi 505180625 190 QWFIKITAYADELLN 204
Cdd:PRK11893 158 SYFFRLSKYQDKLLE 172
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
11-788 |
2.39e-25 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 113.11 E-value: 2.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 11 ESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFG------- 83
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGiatqlvv 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 84 ---LPAEGAAVKNNTAPA------PWTYDNIAYMKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTS 154
Cdd:PLN02943 146 ekmLASEGIKRTDLGRDEftkrvwEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSY 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 155 AVNWCPNDQTVLAneqvidgccwrcDTKVErkeipqwfikitaYADEllndldnldhwPDTVKTMQRNWIGRSEgveisf 234
Cdd:PLN02943 226 MVNWSPNLQTAVS------------DLEVE-------------YSEE-----------PGTLYYIKYRVAGGSE------ 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 235 dvndyaDKLTVYTTRPDTFMGCTYLAVaagHPlaqqaaannpalaafiDECRNTKVaeadmatmekkgvdTGFKAIHPLT 314
Cdd:PLN02943 264 ------DFLTIATTRPETLFGDVAIAV---NP----------------EDDRYSKY--------------IGKMAIVPMT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 315 -GEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPViLAADGS----------------EPDLSEQALTE 377
Cdd:PLN02943 305 yGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNV-MNKDGTlnevaglywfeareklWSDLEETGLAV 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 378 KGVLFN--------SGE----FSGLDYEAGFNAIADK-LAAMGVGERKV---------NYRL---RDWGVSRQRYWGAPI 432
Cdd:PLN02943 384 KKEPHTlrvprsqrGGEviepLVSKQWFVTMEPLAEKaLKAVENGELTIiperfekiyNHWLsniKDWCISRQLWWGHRI 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 433 PMVTL------EDGTVMPTPEDQLPvilpedvvmdgitspiKADPEWAKTtvngMPALRETDTFDTFMESS-WYYARYTC 505
Cdd:PLN02943 464 PVWYIvgkdceEDYIVARSAEEALE----------------KAREKYGKD----VEIYQDPDVLDTWFSSAlWPFSTLGW 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 506 PqydkgmlDPNAANY--WLPVDIYIGGieHAIMHLLYFRFFHKLMRDAGMVnsdePAKQLLCQGMVladafyyvgenger 583
Cdd:PLN02943 524 P-------DVSAEDFkkFYPTTVLETG--HDILFFWVARMVMMGIEFTGTV----PFSYVYLHGLI-------------- 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 584 nwvspidatveRDEKGRivkafdpqgrelvytgmsKMSKSKNNGIDPQVMVERYGADTVRlFMMFASPAEMTLEWQESGV 663
Cdd:PLN02943 577 -----------RDSQGR------------------KMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERL 626
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 664 EGANRFLKRVW---KLVYEH-TSQGPAVALD------------VASLSEDQQALRRDVHKTIAKVTDDIGR-------RQ 720
Cdd:PLN02943 627 TSNKAFTNKLWnagKFVLQNlPSQSDTSAWEhilackfdkeesLLSLPLPECWVVSKLHELIDSVTTSYDKyffgdvgRE 706
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505180625 721 TFNTAIAAVMELMNKLAKAP--QESEQDRALMREALLA-----VVRMLNPFTPHACFTLWQELGGEGD-IDNAPWP 788
Cdd:PLN02943 707 IYDFFWSDFADWYIEASKTRlyHSGDNSALSRAQAVLLyvfenILKLLHPFMPFVTEELWQALPYRKEaLIVSPWP 782
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
7-797 |
1.80e-22 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 104.04 E-value: 1.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 7 PEEiESKVQLHWDENRTFE--VTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGL 84
Cdd:PLN02882 11 PKQ-EEKILSLWSEIDAFKtqLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 85 PAEGAAVKNNtapapwtydNIAYmKNQLKKLGFG-YD---------WSREIATCTPEYYRW----------EQKF----- 139
Cdd:PLN02882 90 PVEYEIDKKL---------GIKR-RDDVLKMGIDkYNeecrsivtrYSKEWEKTVTRTGRWidfendyktmDPKFmesvw 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 140 --FTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtKVERKEIPQWFIKITAyadELLNDLDN--LDHWPDT 215
Cdd:PLN02882 160 wvFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEA----------GLNYKDVSDPAVMVSF---PIVGDPDNasFVAWTTT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 216 VKTMQRNwigrsegveISFDVN---DYadkltVYTTRPDTfmGCTYLAVAAghplaqqaaannPALAAFIDECRNTKVAE 292
Cdd:PLN02882 227 PWTLPSN---------LALCVNpnfTY-----VKVRNKYT--GKVYIVAES------------RLSALPTAKPKSKKGSK 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 293 ADMAT-----MEK-KGVDTGFKAIHPL-------TGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIK-- 357
Cdd:PLN02882 279 PENAAegyevLAKvPGSSLVGKKYEPLfdyfsefSDTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKgg 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 358 --PVILAADG----------------SEPDLSEqALTEKGVLFNSGEF-----------SGLDYEA------GFNAIADK 402
Cdd:PLN02882 359 nlPVPVDDDGcftekvtdfsgryvkdADKDIIA-AIKAKGRLVKSGSIthsypfcwrsdTPLIYRAvpswfvKVEEIKDR 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 403 LAAMG---------VGERKVNYRL---RDWGVSRQRYWGAPIPMVTLEDGT---VMPTPE--DQLPVILPEDV---VMDG 462
Cdd:PLN02882 438 LLENNkqtywvpdyVKEKRFHNWLenaRDWAVSRSRFWGTPLPIWISDDGEevvVIGSIAelEKLSGVKVTDLhrhFIDH 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 463 ITSPIKADPEWakttvngmPALRET-DTFDTFMES-SWYYARYTCPQYDKGMLDPNaanywLPVDIYIGGIEHAimhlly 540
Cdd:PLN02882 518 ITIPSSRGPEF--------GVLRRVdDVFDCWFESgSMPYAYIHYPFENKELFEKN-----FPADFVAEGLDQT------ 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 541 fR-FFHKLmrdagMVNS----DEPA-KQLLCQGMVLAdafyyvgENGErnwvspidatverdekgrivkafdpqgrelvy 614
Cdd:PLN02882 579 -RgWFYTL-----MVLStalfDKPAfKNLICNGLVLA-------EDGK-------------------------------- 613
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 615 tgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMfASP---AEmTLEWQESGVEG-----------ANRFL----KRVwkl 676
Cdd:PLN02882 614 ----KMSKSLKNYPDPNEVIDKYGADALRLYLI-NSPvvrAE-PLRFKEEGVFGvvkdvflpwynAYRFLvqnaKRL--- 684
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 677 vyEHTSQGPAVALDVASLSEDQQALRRDVHKT----IAKVTDDIGRRQTFnTAIAAVMELMNKL--------------AK 738
Cdd:PLN02882 685 --EVEGGAPFVPLDLAKLQNSANVLDRWINSAtqslVKFVREEMGAYRLY-TVVPYLVKFIDNLtniyvrfnrkrlkgRT 761
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505180625 739 APQESEQDRALMREALLAVVRMLNPFTPHACFTLWQEL-----GGEGDIDNAPWPVADESAMVE 797
Cdd:PLN02882 762 GEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLrkvlpGSEESIHYCSFPQVDEGELDE 825
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
42-224 |
4.90e-21 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 95.38 E-value: 4.90e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNI--------------AY 107
Cdd:cd00818 10 PYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMgiaefnakcrefalRY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 108 ---MKNQLKKLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWcPndqtvlaneqVIdgccwrcdtkve 184
Cdd:cd00818 90 vdeQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P----------LI------------ 146
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 505180625 185 RKEIPQWFIKITAYADELLNDLDNLdHW-PDTVKTMQRNWI 224
Cdd:cd00818 147 YRATPQWFIRVTKIKDRLLEANDKV-NWiPEWVKNRFGNWL 186
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
41-224 |
1.16e-19 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 94.06 E-value: 1.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 41 LPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPApwtyDNIAYMKNQ----LKKLG 116
Cdd:PRK00133 10 LPYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPE----ELIARYHAEhkrdFAGFG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 117 FGYD-WSReiaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVL-------------ANEQVIDGC--CWR-- 178
Cdd:PRK00133 86 ISFDnYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLpdrfvkgtcpkcgAEDQYGDNCevCGAty 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 505180625 179 ------------CDTKVERKEIPQWFIKITAYADELLNDLDNLDHWPDTVKTMQRNWI 224
Cdd:PRK00133 163 sptelinpksaiSGATPVLKESEHFFFKLPRFEEFLKEWITRSGELQPNVANKMKEWL 220
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-439 |
8.40e-19 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 91.88 E-value: 8.40e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 81 AFGLPAEGAAVKNNTAPAPWTYDNIAYMK-----------------NQLKKLGFGYDWSREIATCTPEYYRWEQKFFTEL 143
Cdd:PLN02381 176 HAGIATQVVVEKKLMRERHLTRHDIGREEfvsevwkwkdeyggtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 144 YKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdTKVERKEipQWFIKITAYAdellndldnldhwpdtvKTMQRnw 223
Cdd:PLN02381 256 YKEGLIYRDIRLVNWDCTLRTAISDVEV---------DYIDIKE--RTLLKVPGYD-----------------KPVEF-- 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 224 igrseGVEISF--DVNDYADKLTVYTTRPDTFMGCTYLAVaagHPlaqqaaannpalaafiDECRNTKVAeadmatmekk 301
Cdd:PLN02381 306 -----GVLTSFayPLEGGLGEIVVATTRIETMLGDTAIAI---HP----------------DDERYKHLH---------- 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 302 gvdtGFKAIHPLTGEAIPVWA-ANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKpVILAADGSEPDLS--------- 371
Cdd:PLN02381 352 ----GKFAVHPFNGRKLPIICdAILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFI-NIFTDDGKINSNGgsefagmpr 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 372 -------EQALTEKGV-----------------------------LFNSGEFSGLDYEAGFNAIADKLAAMGVGERKVNY 415
Cdd:PLN02381 427 faareavIEALQKKGLyrgaknnemrlglcsrtndvvepmikpqwFVNCSSMAKQALDAAIDGENKKLEFIPKQYLAEWK 506
|
490 500 510
....*....|....*....|....*....|
gi 505180625 416 R----LRDWGVSRQRYWGAPIPM--VTLED 439
Cdd:PLN02381 507 RwlenIRDWCISRQLWWGHRIPAwyVTLED 536
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
697-823 |
4.32e-17 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 78.60 E-value: 4.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 697 DQQALRRdVHKTIAKVTDDIGRRQtFNTAIAAVMELMN--------KLAKAPQESEQD----RALMREALLAVVRMLNPF 764
Cdd:pfam08264 1 DRWILSR-LNKLIKEVTEAYENYR-FNTAAQALYEFFWndlsdwylELIKDRLYGEEPdsraQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505180625 765 TPHACFTLWQELggegDIDNAPWPVADESAMVENTTLV-----VVQVNGKVRGKITVAVDATEE 823
Cdd:pfam08264 79 MPFITEELWQKE----SIHLAPWPEDAELEEAELEEAFelrqeIVQAIRKLRSELKIKKSLPLE 138
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
30-203 |
1.12e-16 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 84.47 E-value: 1.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 30 ESKEKYYCLSMLPYPSGRLHMGHVrnYT--IGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTyDNIAY 107
Cdd:PRK12267 1 MMKKTFYITTPIYYPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYV-DEISA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 108 M-KNQLKKLGFGYDwsREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGC-CWRCDTKVER 185
Cdd:PRK12267 78 GfKELWKKLDISYD--KFIRTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVDGGkCPDCGREVEL 155
|
170
....*....|....*...
gi 505180625 186 KEIPQWFIKITAYADELL 203
Cdd:PRK12267 156 VKEESYFFRMSKYQDRLL 173
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
619-790 |
2.57e-14 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 76.69 E-value: 2.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 619 KMSKSKNNGIDPQVMVERYGADTVRLFMMFASP----AEMTLEwqesgvEGANR-----------FLKRVWKLVYEHT-S 682
Cdd:COG0143 327 KMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPfgqdGDFSWE------DFVARvnsdlandlgnLASRTLSMIHKYFdG 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 683 QGPAvaldVASLSEDQQALRRDVHKTIAKVTDDIGRRQtFNTAIAAVMEL---MNK---------LAKapqesEQDRALM 750
Cdd:COG0143 401 KVPE----PGELTEADEELLAEAEAALEEVAEAMEAFE-FRKALEEIMALaraANKyidetapwkLAK-----DEDPERL 470
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 505180625 751 REAL---LAVVR----MLNPFTPHACFTLWQELGGEGD---IDNAPWPVA 790
Cdd:COG0143 471 ATVLytlLEALRilaiLLKPFLPETAEKILEQLGLEGDeltWEDAGWPLP 520
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
619-784 |
2.96e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 70.21 E-value: 2.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 619 KMSKSKNNGIDPQVMVERYGADTVRLFMM----FASPAEMTlewQESGVE----------G--ANRFLKRVWKlvYEHtS 682
Cdd:PRK12267 299 KMSKSKGNVVDPEELVDRYGLDALRYYLLrevpFGSDGDFS---PEALVErinsdlandlGnlLNRTVAMINK--YFD-G 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 683 QGPAVAlDVASLSEDqqaLRRDVHKTIAKVTDDIGRRQtFNTAIAAVMEL---MNK---------LAKAPQESEQDRALM 750
Cdd:PRK12267 373 EIPAPG-NVTEFDEE---LIALAEETLKNYEELMEELQ-FSRALEEVWKLisrANKyidetapwvLAKDEGKKERLATVM 447
|
170 180 190
....*....|....*....|....*....|....*..
gi 505180625 751 R---EALLAVVRMLNPFTPHACFTLWQELGGEGDIDN 784
Cdd:PRK12267 448 YhlaESLRKVAVLLSPFMPETSKKIFEQLGLEEELTS 484
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
9-92 |
4.59e-10 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 63.55 E-value: 4.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 9 EIESKVQLHWDENRTFEV--TEDESK--EKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGL 84
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAeaGDEPPKpgEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGM 96
|
....*...
gi 505180625 85 PAEGAAVK 92
Cdd:PLN02959 97 PIKASADK 104
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
9-663 |
5.66e-10 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 63.45 E-value: 5.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 9 EIESKVQLHWDENRTFEVTEDESKEK--YYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPA 86
Cdd:PTZ00427 76 EEEEKVLKYWKSIDAFNTSNKLAKNKkaYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 87 EGAAVKNNTAPAPWTYDNIA--------------YMKNQLK---KLGFGYDWSREIATCTPEYYRWEQKFFTELYKKGLV 149
Cdd:PTZ00427 156 EYEIEKENNINKKEDILKMGidvynekcrgivlkYSNEWVKtveRIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYV 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 150 YKKTSAVNWCPNDQTVLANEQVidgccwrcdtKVERKEIPQWFIKITAYADELLNDLDNLDHWPDTVKTM---------- 219
Cdd:PTZ00427 236 YKSFKVMPYSCKCNTPISNFEL----------NLNYKDTPDPSIIISFVLCSDFPKVEEECNIEEDKQLLgekysvlynn 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 220 -QRNWigrSEGVEISFDVNDYA--DKLTVYTTRPDTFMgcTYLAVAAGHPLAQQAAANNPALAAFI-DECR--------- 286
Cdd:PTZ00427 306 kRENS---NNGNNNSTNNVCYAqhSEILAWTTTPWTLP--SNLALCVNEHFTYLRIHHVKSNRVVIvGECRlewimkelk 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 287 ----NTKVAE----ADMATMEKKGVDTGFKAIHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGL---- 354
Cdd:PTZ00427 381 wnveDLKIVNrfkgKELKGLRYKPLFTNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidpe 460
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 355 -NIKPVILAADG---SEPDL------------------SEQALTEKGVLFNSGEF-----SGLDYE---AGFNAIADKLA 404
Cdd:PTZ00427 461 kNIFIDPLDANGyftNEVEEvqnlyikeadnvikkklkNENRLLSNNTIVHSYPFcwrsdTPLIYRaipAWFIRVSNSTN 540
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 405 AM------------GVGERKVNYRL---RDWGVSRQRYWGAPIPMVTLEDgtvMPTpedqlpVILPEDVVMDGITSPIKA 469
Cdd:PTZ00427 541 ELvknnettywipaHIKEKKFHNWIkdaKDWCISRNRYWGTPIPIWADEK---MET------VICVESIKHLEELSGVKN 611
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 470 DPEWAKTTVNGM----------PAL-RETDTFDTFMES-SWYYARYTCPqydkGMLDPNAANYWLPVDIYIGGIEHAimh 537
Cdd:PTZ00427 612 INDLHRHFIDHIeiknpkgktyPKLkRIPEVFDCWFESgSMPYAKVHYP----FSTEKEDFHKIFPADFIAEGLDQT--- 684
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 538 llyFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADafyyvgengernwvspidatverDEKgrivkafdpqgrelvytgm 617
Cdd:PTZ00427 685 ---RGWFYTLLVISTLLFDKAPFKNLICNGLVLAS-----------------------DGK------------------- 719
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 505180625 618 sKMSKSKNNGIDPQVMVERYGADTVRLFMM--FASPAEmTLEWQESGV 663
Cdd:PTZ00427 720 -KMSKRLKNYPDPLYILDKYGADSLRLYLInsVAVRAE-NLKFQEKGV 765
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
619-783 |
3.07e-09 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 60.12 E-value: 3.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 619 KMSKSKNNGIDPQVMVERYGADTVRLFMMFA---SPaemtLEWQESGVEGANRFLKRvwklVYEHTSQGPAVALDVASLS 695
Cdd:COG0215 265 KMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAhyrSP----LDFSEEALEEAEKALER----LYNALRRLEEALGAADSSA 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 696 EDQQALRRDVHKTIAkvtDDigrrqtFNT--AIAAVMELMNKLAKApQESEQDRALMREALLAVVRM-----LNPFTPHA 768
Cdd:COG0215 337 EEIEELREEFIAAMD---DD------FNTpeALAVLFELVREINKA-LDEGEDKAALAALAALLRALggvlgLLLLEPEA 406
|
170
....*....|....*
gi 505180625 769 cftlWQELGGEGDID 783
Cdd:COG0215 407 ----WQGAAEDELLD 417
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
25-202 |
2.78e-07 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 54.33 E-value: 2.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 25 EVTEDESkEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPaPWTYDN 104
Cdd:PLN02224 62 ESTVDEA-DTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNP-PEHCDI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 105 IAYMKNQL-KKLGFGYDwsREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCwrCDTK- 182
Cdd:PLN02224 140 ISQSYRTLwKDLDIAYD--KFIRTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNCEEYKDEKELLENNC--CPVHq 215
|
170 180
....*....|....*....|...
gi 505180625 183 ---VERKEiPQWFIKITAYADEL 202
Cdd:PLN02224 216 mpcVARKE-DNYFFALSKYQKPL 237
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
619-653 |
1.22e-04 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 45.36 E-value: 1.22e-04
10 20 30
....*....|....*....|....*....|....*
gi 505180625 619 KMSKSKNNGIDPQVMVERYGADTVRLFMMFASPAE 653
Cdd:pfam09334 324 KMSKSRGNVVWPSEALDRFPPDALRYYLARNRPET 358
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
658-776 |
2.46e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 41.42 E-value: 2.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 658 WQESGVEGANRFLKRVWKLVYEHTSQGPAVA----LDVASLSEdqqalrrdVHKTIAKVTDDIGRRQTFNTAIAAVMELM 733
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEGELEeltfIDRWLLSR--------LNRLIKETTEAYENMQFREALKEGLYELQ 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 505180625 734 NKLAKAPQ--ESEQDRALMREALLAVVRMLNPFTPHACFTLWQEL 776
Cdd:cd07959 73 NDLDWYRErgGAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
660-776 |
3.22e-04 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 41.39 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 660 ESGVEGANRFLKRVW---KLVYEHTSQGPAVALDVASLSEDQQALRRDVHKTIAKVTDDIGRRQtFNTAIAAV------- 729
Cdd:cd07962 3 EKRVEGGRNFCNKLWnaaRFVLMNLEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYR-FSEAATALyeffwnd 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 505180625 730 -----MELMNKLAKAPQESEQD--RALMREALLAVVRMLNPFTPHACFTLWQEL 776
Cdd:cd07962 82 fcdwyLELVKPRLYGEDEEEKKaaRATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| argS |
TIGR00456 |
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed ... |
42-74 |
4.12e-04 |
|
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273085 [Multi-domain] Cd Length: 563 Bit Score: 43.87 E-value: 4.12e-04
10 20 30
....*....|....*....|....*....|...
gi 505180625 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVL 74
Cdd:TIGR00456 121 ANPAGPLHVGHLRNAIIGDSLARILEFLGYDVI 153
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
42-74 |
7.23e-04 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 41.78 E-value: 7.23e-04
10 20 30
....*....|....*....|....*....|...
gi 505180625 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVL 74
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
39-175 |
1.30e-03 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 42.46 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 39 SMLPYPSGRLHMGHVrnytIG-----DVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPwTYDNIAYMKNQLK 113
Cdd:PLN02610 23 SALPYVNNVPHLGNI----IGcvlsaDVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKE-ICDKYHAIHKEVY 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505180625 114 KLgFGYDWSREIATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGC 175
Cdd:PLN02610 98 DW-FDISFDKFGRTSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLVEGTC 158
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
758-792 |
1.46e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 42.36 E-value: 1.46e-03
10 20 30
....*....|....*....|....*....|....*.
gi 505180625 758 VRMLNPFTPHACFTLWQE-LGGEGDIDNAPWPVADE 792
Cdd:PLN02959 859 TRLITPICPHYAEHVWREiLKKEGFAVTAGWPVAGE 894
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
660-765 |
2.03e-03 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 39.03 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 660 ESGVEGANRFLKRVWKLV-YEHTSQGPAVA-LDVASLSEDQQALRRDVHKTIAKVTDDIgRRQTFNTAIAAVMELMNKL- 736
Cdd:cd07375 1 EERLKQARAFLNRLYRLLsFFRKALGGTQPkWDNELLEEADRELLARLQEFIKRTTNAL-EALDPTTAVQELFKFTNELn 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 505180625 737 ---------AKAPQESEQDRALMREALLAVVRMLNPFT 765
Cdd:cd07375 80 wyldelkpaLQTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
752-793 |
2.66e-03 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 39.84 E-value: 2.66e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 505180625 752 EALLAVVRMLNPFTPHACFTLWQELGGEGDIDN-----APWPVADES 793
Cdd:cd07961 116 EVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPesvhlLDWPEVDES 162
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
693-776 |
6.76e-03 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 37.47 E-value: 6.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180625 693 SLSEDQQALRRDVHKTIAKVTDDIGRRQtFNTAIAAVMEL---MNK---------LAKapqesEQDRALMREAL---LAV 757
Cdd:cd07957 33 GLTEEDEELLEEAEELLEEVAEAMEELE-FRKALEEIMELaraANKyidetapwkLAK-----EEDPERLATVLyvlLEL 106
|
90 100
....*....|....*....|...
gi 505180625 758 VR----MLNPFTPHACFTLWQEL 776
Cdd:cd07957 107 LRilaiLLSPFMPETAEKILDQL 129
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
42-112 |
8.71e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 37.46 E-value: 8.71e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505180625 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQL 112
Cdd:cd00802 6 ITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKEDV 76
|
|
| |
