NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|505180605|ref|WP_015367707|]
View 

MULTISPECIES: glucosamine-6-phosphate deaminase [Klebsiella]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10794581)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 0e+00

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


:

Pssm-ID: 129593  Cd Length: 259  Bit Score: 506.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605    1 MRLIPLVTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   81 HPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  161 TLTHDTRVANSRFFDGDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 505180605  241 EPSTMELKVKTLKYFNELE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
 
Name Accession Description Interval E-value
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 0e+00

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 506.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605    1 MRLIPLVTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   81 HPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  161 TLTHDTRVANSRFFDGDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 505180605  241 EPSTMELKVKTLKYFNELE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-261 2.27e-180

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 495.89  E-value: 2.27e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   1 MRLIPLVTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  81 HPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605 161 TLTHDTRVANSRFFDGDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|.
gi 505180605 241 EPSTMELKVKTLKYFNELEAE 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-247 1.10e-134

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 379.14  E-value: 1.10e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  10 EQVGKWAARHIVNRINAFKPtadrpFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYHSFM 89
Cdd:cd01399    1 EEMSEAAAELIAELIREKPP-----AVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  90 HRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVA 169
Cdd:cd01399   76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505180605 170 NSRFFDGDvDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVCDEPSTMEL 247
Cdd:cd01399  156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 5.40e-118

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 337.52  E-value: 5.40e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   1 MRLIPLVTAEQVGKWAARHIVNRINAFkpTADRP-FVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPK 79
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIAEA--IAEKGrAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  80 EHPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRT-R 158
Cdd:COG0363   80 DHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605 159 IKTLTHDTRVANSRFFDgDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVV 238
Cdd:COG0363  160 VVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWF 238

                        250
                 ....*....|
gi 505180605 239 CDEPSTMELK 248
Cdd:COG0363  239 LDEAAASLLT 248
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
8-223 5.98e-25

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 98.85  E-value: 5.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605    8 TAEQVGKWAARHIVNRINAFkpTADR-PFVLGLPTGGTPLTAYKALVEMHkaGQVSFKHVVTFNMDE-YVglPKEHPESY 85
Cdd:pfam01182   2 DAEALAQALAERLAEALEAA--LAERgRFTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDSN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   86 HSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGK---------IHLfmgGVGNDGHIA--F-NEPAssL 153
Cdd:pfam01182  76 YGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvfdlVLL---GMGPDGHTAslFpGSPA--L 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  154 ASRTRIKTLTHDTRVAnsrffdgdvdlvPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHM 223
Cdd:pfam01182 151 EETDRLVVAVTDSPKP------------PPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
 
Name Accession Description Interval E-value
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 0e+00

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 506.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605    1 MRLIPLVTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   81 HPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  161 TLTHDTRVANSRFFDGDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 505180605  241 EPSTMELKVKTLKYFNELE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-261 2.27e-180

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 495.89  E-value: 2.27e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   1 MRLIPLVTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  81 HPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605 161 TLTHDTRVANSRFFDGDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|.
gi 505180605 241 EPSTMELKVKTLKYFNELEAE 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 3.29e-145

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 406.84  E-value: 3.29e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   1 MRLIPLVTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  81 HPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605 161 TLTHDTRVANSRFFDGDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 505180605 241 EPSTMELKVKTLK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-247 1.10e-134

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 379.14  E-value: 1.10e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  10 EQVGKWAARHIVNRINAFKPtadrpFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYHSFM 89
Cdd:cd01399    1 EEMSEAAAELIAELIREKPP-----AVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  90 HRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVA 169
Cdd:cd01399   76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505180605 170 NSRFFDGDvDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVCDEPSTMEL 247
Cdd:cd01399  156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 5.40e-118

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 337.52  E-value: 5.40e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   1 MRLIPLVTAEQVGKWAARHIVNRINAFkpTADRP-FVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPK 79
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIAEA--IAEKGrAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  80 EHPESYHSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRT-R 158
Cdd:COG0363   80 DHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605 159 IKTLTHDTRVANSRFFDgDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVV 238
Cdd:COG0363  160 VVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWF 238

                        250
                 ....*....|
gi 505180605 239 CDEPSTMELK 248
Cdd:COG0363  239 LDEAAASLLT 248
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 16-247 8.87e-81

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 255.34  E-value: 8.87e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  16 AARHIVNRINAF---KPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYHSFMHRN 92
Cdd:PRK02122  39 ASRAVAQEIATLireRQAEGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQSYHRFMKEN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  93 FFDHVDIPAENINLLNGNAP--DIDAECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVAN 170
Cdd:PRK02122 119 LFDHVDIPPENIHIPDGTIPkeEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVTLDHITRRDA 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505180605 171 SRFFdGDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVCDEPSTMEL 247
Cdd:PRK02122 199 ASDF-FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLAAASEL 274
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 13-239 4.29e-73

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 221.07  E-value: 4.29e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  13 GKWAARHIVNRINAFkPTADRPFVLGLPTGGTPLTAYKALVEMHKAGqvSFKHVVTFNMDEYVGLPKeHPESYHSFMHRN 92
Cdd:cd00458    1 AKEALKFIEDK*EKL-LEEKDDMVIGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPLD-SDQSNFRQAKLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  93 FFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGKIHLFMGGVGNdghiafnepasslasrtriktlthdtrvansr 172
Cdd:cd00458   77 AFEHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAGY-------------------------------- 124

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505180605 173 ffdgdvdlvpkyaltvgvgtllDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVC 239
Cdd:cd00458  125 ----------------------RAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 36-239 1.17e-32

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 119.16  E-value: 1.17e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  36 VLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYHSFMHRNFFDHVDIPAENINLLNGNAPDiD 115
Cdd:PRK09762  31 VICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-E 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605 116 AECRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLthDTRVANSRFFDGDVDlVPKYALTVGVGTLLD 195
Cdd:PRK09762 110 TECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQL--DARTQQHEMLKTAGR-PVTRGITLGLKDILN 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 505180605 196 AEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKavVVC 239
Cdd:PRK09762 187 AREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSN--FIC 228
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
8-223 5.98e-25

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 98.85  E-value: 5.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605    8 TAEQVGKWAARHIVNRINAFkpTADR-PFVLGLPTGGTPLTAYKALVEMHkaGQVSFKHVVTFNMDE-YVglPKEHPESY 85
Cdd:pfam01182   2 DAEALAQALAERLAEALEAA--LAERgRFTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDSN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   86 HSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRRYEEKIRSYGK---------IHLfmgGVGNDGHIA--F-NEPAssL 153
Cdd:pfam01182  76 YGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvfdlVLL---GMGPDGHTAslFpGSPA--L 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  154 ASRTRIKTLTHDTRVAnsrffdgdvdlvPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHM 223
Cdd:pfam01182 151 EETDRLVVAVTDSPKP------------PPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-247 1.77e-20

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 87.11  E-value: 1.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   1 MRLIPLVTAEQVGKWAARHIVNRInafkpTADRPFVLGLPTGGTPLTAYKALVEMHKaGQVSFKHVVTFNMDEyvgLPKE 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYM-----SKTKRVNLAITAGSTPKGMYEYLITLVK-GKAWYDNVHYYNFDE---IPFR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  81 HPESYH---SFMHRNFFDHVDIPAENINLLN-GNApdidaecRRYEEKIRSYGKIHLFMGGVGNDGHIAFNEPA-SSLAS 155
Cdd:PRK12358  72 GKEGEGvtiTNLRNLFFTPAGIKEENIHKLTiDNY-------REHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHD 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605 156 RTRIKTLTHDTR--VANSRFfDGDVDLVPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHP 233
Cdd:PRK12358 145 ETVEVPIQGEMVdiVAHGEL-GGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHP 223

                        250
                 ....*....|....
gi 505180605 234 KAVVVCDEPSTMEL 247
Cdd:PRK12358 224 NLTVILDEAAAAEL 237
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 10-239 5.53e-20

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 85.31  E-value: 5.53e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  10 EQVGKWAARHIVNRINAfKPTADRPFVLGLPTGGTPLTAYKALVEMHkagQVSFKHVVTFNMDE-YVglPKEHPESYHSF 88
Cdd:cd01400    1 EALAEALADRIAEALAA-AIAKRGRFSLALSGGSTPKPLYELLAAAP---ALDWSKVHVFLGDErCV--PPDDPDSNYRL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  89 MHRNFFDHVDIPAENINLLNGNApDIDAECRRYEEKIRS----YGKIHLFMGGVGNDGHIA--FNEPASSLASRTRIKTL 162
Cdd:cd01400   75 AREALLSHVAIPAANIHPIPTEL-GPEDAAAAYEKELRAlfggVPPFDLVLLGMGPDGHTAslFPGHPALLEETDRLVVA 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505180605 163 THDTRVAnsrffdgdvdlvPKYALTVGVGTLLDAEEVMILVLGHQKALALQAAVEGNVNHMWTITCLQLHPKAVVVC 239
Cdd:cd01400  154 VTDSPKP------------PPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWF 218
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 35-242 8.56e-15

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 71.64  E-value: 8.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605   35 FVLGLPTGGTPLTAYKALVEMhkagQVSFKHVVTFNMDE-YVglPKEHPESYHSFMHRNFFDHVDIPAENINLLNGNAPD 113
Cdd:TIGR01198  30 FSLALSGGRSPIALLEALAAQ----PLDWSRIHLFLGDErYV--PLDHADSNTGLAREALLDRVAIPASNIHPMPTELSD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505180605  114 IDAECRRYEEKIRSY------GKIHLFMGGVGNDGHIA--FNEpASSLASRTRIKTLTHDtrvansrffDGDvdlVPKYA 185
Cdd:TIGR01198 104 IEEAAELYEQELAAAfqpivfPVFDLLLLGMGPDGHTAslFPH-TPALQETERLVTVLTK---------SPK---PPHER 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 505180605  186 LTVGVGTLLDAEEVMILVLGHQKALALQAAVE-GNVNHMWTITCLQLHPKAVVVCDEP 242
Cdd:TIGR01198 171 ITLTLPAINAARKVFLLIAGEEKRNALAEALAvEAEPYPLPAAGVLHSGKTLWLLDYA 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH