|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
3-401 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 656.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 3 ESAFAERIVHNLLDTDFYKLTMMQGVLHNYPDADVEWEFRCRNGE-DLRPYLGEIRNQLELLSDLTLDDGQLAFLERISF 81
Cdd:PRK05321 1 HTWKADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 82 LKPDFLRFLRLFRFNLRYVRLGIENDQLFLRLKGPWLHVILFEVPLLAIISEVRNRHLHPRMRLAEARDQLYRKFDWLRA 161
Cdd:PRK05321 81 FKPDFLDWLRLFRLNPYEVTVSIDDGQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIELLKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 162 hanEDELAELQVADFGTRRRFSSRVQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHQQLGPRLIDSQ 241
Cdd:PRK05321 161 ---LPDLSGFKIADFGTRRRFSFEWQEEVVEALKEGLPGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 242 IAALDCWVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGEPVAWAEKAIAHYQKLGIDPMTKTLVFSDGLN 321
Cdd:PRK05321 238 YAALEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 322 LTRSLEIFRALRGRINVSFGIGTNLTCDIPGVAPMSIVLKMTDCNGAPVAKISDEAAKTQCRDENFVAYMRHVFKVPSKE 401
Cdd:PRK05321 318 FDKALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVFGLPLVV 397
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
12-380 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 527.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 12 HNLLDTDFYKLTMMQGVLHNYPDADVEWEFRCRNGED-LRPYLGEIRNQLELLSDLTLDDGQLAFLER-ISFLKPDFLRF 89
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPEDfLEEAAEALREQIDHLANLRFSEEELAYLRRsLPFLKPDYLDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 90 LRLFRFNLRYV--RLGIENDQLFLRLKGPWLHVILFEVPLLAIISEVRNRHLHPRMRLAEARDQLYRKFDWLRAHANEDE 167
Cdd:cd01401 81 LELFRLNPEEVvvRLDTGKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 168 LAELQVADFGTRRRFSSRVQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHQQLGPRLIDSQIAALDC 247
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKQAAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 248 WVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGEPVAWAEKAIAHYQKLGIDPMTKTLVFSDGLNLTRSLE 327
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 505084887 328 IFRALRGRINVSFGIGTNLTCDIP---GVAPMSIVLKMTDCNGAPVAKISDEAAKT 380
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGnkeKSTPLNIVIKLVECNGRPVAKISDSPGKN 376
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
10-398 |
2.96e-150 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 430.72 E-value: 2.96e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 10 IVHNLLDTDFYKLTMMQGVLHNYPDADVEWEFRCRNGE-DLRPYLGEIRNQLELLSDLTLDDGQLAFLER-ISFLKPDFL 87
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQlFLKEAAEALREEISALGNLRFTDDEIEYLKQeLPYLKSDYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 88 RFLRL-FRFNLRYVRLGI-ENDQLFLRLKGPWLHVILFEVPLLAIISEVRNRHLHPRMRLAEARDQLYRKFDWLRAHANE 165
Cdd:TIGR01514 81 DYLRNfRFHPEEQVEVGIdDKGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 166 DELAE--LQVADFGTRRRFSSRVQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHQQLGPrLIDSQIA 243
Cdd:TIGR01514 161 ETMFEngFRFSEFGTRRRFSLEVQDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 244 ALDCWVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGEPVAWAEKAIAHYQKLGIDPMTKTLVFSDGLNLT 323
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505084887 324 RSLEIFRALRGRINVSFGIGTNLTCDIPGVAPMSIVLKMTDCNGAPVAKISDEAAKTQCRDENFVAYMRHVFKVP 398
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELFDTP 394
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
171-398 |
3.89e-108 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 317.79 E-value: 3.89e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 171 LQVADFGTRRRFSSRVQEEVVRvlrdDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHQQLGPRLIDSQIAALDCWVR 250
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQEIVGL----AHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 251 EYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGEPVAWAEKAIAHYQKL-GIDPMTKTLVFSDGLNLTRSLEIF 329
Cdd:pfam04095 77 EYRGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTlNIDGYTKRLIFSDGLDVEKIIELL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505084887 330 RALRG-RINVSFGIGTNLTCDIPG--------VAPMSIVLKMTDCNGAPVAKISDEAAKTQCRDENFVAYMRHVFKVP 398
Cdd:pfam04095 157 EYFKGkGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFDNG 234
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
14-380 |
3.51e-25 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 106.39 E-value: 3.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 14 LLDTDFYKLTMMQGVLHN-YPDADVEWEFRCRNGEDLRPY-----LGEIrnqLELLSDLTLDDGQLAFLERISFLKPDFL 87
Cdd:COG1488 5 ALLTDLYKLTMAQAYLPEgTANRRAVFELFFRRLPFGRGYvvfagLQRF---LKYLENLRFTEEDIAYLRSLGVFDEDFL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 88 RFlrlfrfnlryvrlgIENDQL------------------FLRLKGPWLHVILFEVPLLAIISevrnrhlHP-------- 141
Cdd:COG1488 82 DY--------------LADFRFpgdiravpegtvvfpgepLLTVEGTLPEAQLLETLLLNILN-------YPtliatkaa 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 142 RMRLAeARDQlyrkfdwlrahanedelaelQVADFGTRRrfssrVQEE--VVRVLRDDFPGRFVGTSNVDLAWKLDIKPL 219
Cdd:COG1488 141 RIVQA-AGGR--------------------PLHDFGLRR-----AHGLeaAVAAARAAYLAGFAGTSNVLAGRYYGIPSV 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 220 GTMAHEWIMAHqqlgprliDSQIAALDCWVREYRGLLgIALTDciTMDAF--------LGDfDLYFAKLFDGLRHDSGEP 291
Cdd:COG1488 195 GTMAHSFVQAH--------DDELEAFRAFAEAYPDGT-TLLVD--TYDTLsgvpnaieLAK-ELLARGGLLGIRLDSGDL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 292 VAWAEKAIAHYQKLGIDPMtkTLVFSDGLNLTRSLEIFRAlRGRINVsFGIGTNLtcdIPGV-AP-MSIVLKMTDCNGA- 368
Cdd:COG1488 263 AYLSKQARELLDEAGLPDV--RIIASDDLDEYRIAALLEQ-GAPIDV-FGVGTRL---VTSSdRPtLGFVYKLVAVEGDg 335
|
410
....*....|....*
gi 505084887 369 ---PVAKISDEAAKT 380
Cdd:COG1488 336 ewrPVIKLSETPGKK 350
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
3-401 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 656.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 3 ESAFAERIVHNLLDTDFYKLTMMQGVLHNYPDADVEWEFRCRNGE-DLRPYLGEIRNQLELLSDLTLDDGQLAFLERISF 81
Cdd:PRK05321 1 HTWKADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 82 LKPDFLRFLRLFRFNLRYVRLGIENDQLFLRLKGPWLHVILFEVPLLAIISEVRNRHLHPRMRLAEARDQLYRKFDWLRA 161
Cdd:PRK05321 81 FKPDFLDWLRLFRLNPYEVTVSIDDGQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIELLKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 162 hanEDELAELQVADFGTRRRFSSRVQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHQQLGPRLIDSQ 241
Cdd:PRK05321 161 ---LPDLSGFKIADFGTRRRFSFEWQEEVVEALKEGLPGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 242 IAALDCWVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGEPVAWAEKAIAHYQKLGIDPMTKTLVFSDGLN 321
Cdd:PRK05321 238 YAALEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 322 LTRSLEIFRALRGRINVSFGIGTNLTCDIPGVAPMSIVLKMTDCNGAPVAKISDEAAKTQCRDENFVAYMRHVFKVPSKE 401
Cdd:PRK05321 318 FDKALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVFGLPLVV 397
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
12-380 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 527.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 12 HNLLDTDFYKLTMMQGVLHNYPDADVEWEFRCRNGED-LRPYLGEIRNQLELLSDLTLDDGQLAFLER-ISFLKPDFLRF 89
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPEDfLEEAAEALREQIDHLANLRFSEEELAYLRRsLPFLKPDYLDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 90 LRLFRFNLRYV--RLGIENDQLFLRLKGPWLHVILFEVPLLAIISEVRNRHLHPRMRLAEARDQLYRKFDWLRAHANEDE 167
Cdd:cd01401 81 LELFRLNPEEVvvRLDTGKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 168 LAELQVADFGTRRRFSSRVQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHQQLGPRLIDSQIAALDC 247
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKQAAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 248 WVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGEPVAWAEKAIAHYQKLGIDPMTKTLVFSDGLNLTRSLE 327
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 505084887 328 IFRALRGRINVSFGIGTNLTCDIP---GVAPMSIVLKMTDCNGAPVAKISDEAAKT 380
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGnkeKSTPLNIVIKLVECNGRPVAKISDSPGKN 376
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
10-398 |
2.96e-150 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 430.72 E-value: 2.96e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 10 IVHNLLDTDFYKLTMMQGVLHNYPDADVEWEFRCRNGE-DLRPYLGEIRNQLELLSDLTLDDGQLAFLER-ISFLKPDFL 87
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQlFLKEAAEALREEISALGNLRFTDDEIEYLKQeLPYLKSDYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 88 RFLRL-FRFNLRYVRLGI-ENDQLFLRLKGPWLHVILFEVPLLAIISEVRNRHLHPRMRLAEARDQLYRKFDWLRAHANE 165
Cdd:TIGR01514 81 DYLRNfRFHPEEQVEVGIdDKGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 166 DELAE--LQVADFGTRRRFSSRVQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHQQLGPrLIDSQIA 243
Cdd:TIGR01514 161 ETMFEngFRFSEFGTRRRFSLEVQDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 244 ALDCWVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGEPVAWAEKAIAHYQKLGIDPMTKTLVFSDGLNLT 323
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505084887 324 RSLEIFRALRGRINVSFGIGTNLTCDIPGVAPMSIVLKMTDCNGAPVAKISDEAAKTQCRDENFVAYMRHVFKVP 398
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELFDTP 394
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
171-398 |
3.89e-108 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 317.79 E-value: 3.89e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 171 LQVADFGTRRRFSSRVQEEVVRvlrdDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHQQLGPRLIDSQIAALDCWVR 250
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQEIVGL----AHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 251 EYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGEPVAWAEKAIAHYQKL-GIDPMTKTLVFSDGLNLTRSLEIF 329
Cdd:pfam04095 77 EYRGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTlNIDGYTKRLIFSDGLDVEKIIELL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505084887 330 RALRG-RINVSFGIGTNLTCDIPG--------VAPMSIVLKMTDCNGAPVAKISDEAAKTQCRDENFVAYMRHVFKVP 398
Cdd:pfam04095 157 EYFKGkGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFDNG 234
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
14-361 |
6.40e-96 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 290.33 E-value: 6.40e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 14 LLDTDFYKLTMMQGVLHNYPDADVEWEFRCRNGEDLRPY--LGEIRNQLELLSDLTLDDGQLAFLERisfLKPDFLRFLR 91
Cdd:cd01567 1 LLDTDLYKLTMMQAYLYPYPNTRVVFEFTFRSNPFGGDYivFAGLEEVLKLLENLRFTEEEIEYLKK---LLIFGEFFLY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 92 LFRFNLRYVRL-----G--IENDQLFLRLKGPWLHVILFEVPLLAIISEVRNRHLHPRMRLAEARDQLYRKFdwlrahan 164
Cdd:cd01567 78 LLFLGKLPLEIyalpeGtvVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLLETKD-------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 165 EDELAELQVADFGTRRRFSsrvQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHQQLgprlIDSQIAA 244
Cdd:cd01567 150 NLEELGFKLHDFGTRRRHS---PEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGAL----EEAAFEA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 245 LDCWVREYRGLLGIALTDCITMD-AFLGDFDLYFAKL----FDGLRHDSGEPVAWAEKAIAHYQKLGIDPMTKTLVFSDG 319
Cdd:cd01567 223 FARWLPQFGGGLGIALIDTYDTDnGFLNALKLAKALGagggLLGVRLDSGDPVELIKKVRKHLDELGIDLNKKKIIISGD 302
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 505084887 320 LNLTRSLEIFRALRGRINVSFGIGTNLTCDIpGVAPMSIVLK 361
Cdd:cd01567 303 LDTEEAIELLLEQGASPNDAFGVGTSLTNDL-GRPPLGFVYK 343
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
18-361 |
6.40e-47 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 162.02 E-value: 6.40e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 18 DFYKLTMMQGvlHNYPDADVEWEFRCRngEDLRPYLGEIRNQLELLSDLTLDDgqlaflERISFLKPDFLRflrlfrfnl 97
Cdd:cd00516 1 DLYKLTMIQA--YPPPDTRATAEFTAR--EDPYGVLAGLEEALELLELLRFPG------PLVILAVPEGTV--------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 98 ryvrlgIENDQLFLRLKGPWLHVILFEVPLLAIISEVRNRHLHPRMRLAEARDQLYRkfdwlrahanedelaelqVADFG 177
Cdd:cd00516 62 ------VEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAKGANTK------------------VHDFG 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 178 TRRRFS-SRVQEevvrvLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHqqlgprLIDSQIAALDCWVREyrglL 256
Cdd:cd00516 118 TRKTTPgLRLLE-----KYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF------GELAAVKALRRWLPE----L 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 257 GIALTDCITMDaFLGDFDLYFAKLFDGLRHDSGE-----PVAWAEKAIAHYQklGIDPMTKTLVFSDGLNltrsLEIFRA 331
Cdd:cd00516 183 FIALIDVEVDT-LEEALEAAKAGGADGIRLDSGSpeeldPAVLILKARAHLD--GKGLPRVKIEASGGLD----EENIRA 255
|
330 340 350
....*....|....*....|....*....|
gi 505084887 332 LRGRINVSFGIGTNLTCDipgvAPMSIVLK 361
Cdd:cd00516 256 YAETGVDVFGVGTLLHSA----PPLDIVLK 281
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
15-132 |
2.72e-28 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 107.60 E-value: 2.72e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 15 LDTDFYKLTMMQGVLHNYPDADVEWEFRCRN--GEDLRPYLGEIRNQLELLSDLTLDDGQLAFLER-ISFLKPDFLRFLR 91
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQVVFEFFNRTnpFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRsLPYFKPDFLDYLR 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 505084887 92 LFRFNLRYVRL----GIENDQLFLRLKGPWLHVILFEVPLLAIIS 132
Cdd:pfam17767 81 NFRFDPSIVAVpegeVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
14-380 |
3.51e-25 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 106.39 E-value: 3.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 14 LLDTDFYKLTMMQGVLHN-YPDADVEWEFRCRNGEDLRPY-----LGEIrnqLELLSDLTLDDGQLAFLERISFLKPDFL 87
Cdd:COG1488 5 ALLTDLYKLTMAQAYLPEgTANRRAVFELFFRRLPFGRGYvvfagLQRF---LKYLENLRFTEEDIAYLRSLGVFDEDFL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 88 RFlrlfrfnlryvrlgIENDQL------------------FLRLKGPWLHVILFEVPLLAIISevrnrhlHP-------- 141
Cdd:COG1488 82 DY--------------LADFRFpgdiravpegtvvfpgepLLTVEGTLPEAQLLETLLLNILN-------YPtliatkaa 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 142 RMRLAeARDQlyrkfdwlrahanedelaelQVADFGTRRrfssrVQEE--VVRVLRDDFPGRFVGTSNVDLAWKLDIKPL 219
Cdd:COG1488 141 RIVQA-AGGR--------------------PLHDFGLRR-----AHGLeaAVAAARAAYLAGFAGTSNVLAGRYYGIPSV 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 220 GTMAHEWIMAHqqlgprliDSQIAALDCWVREYRGLLgIALTDciTMDAF--------LGDfDLYFAKLFDGLRHDSGEP 291
Cdd:COG1488 195 GTMAHSFVQAH--------DDELEAFRAFAEAYPDGT-TLLVD--TYDTLsgvpnaieLAK-ELLARGGLLGIRLDSGDL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 292 VAWAEKAIAHYQKLGIDPMtkTLVFSDGLNLTRSLEIFRAlRGRINVsFGIGTNLtcdIPGV-AP-MSIVLKMTDCNGA- 368
Cdd:COG1488 263 AYLSKQARELLDEAGLPDV--RIIASDDLDEYRIAALLEQ-GAPIDV-FGVGTRL---VTSSdRPtLGFVYKLVAVEGDg 335
|
410
....*....|....*
gi 505084887 369 ---PVAKISDEAAKT 380
Cdd:COG1488 336 ewrPVIKLSETPGKK 350
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
15-380 |
1.66e-18 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 86.64 E-value: 1.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 15 LDTDFYKLTMMQGVL-HNYPDADVEWEFRCRNGEDLRPYL--GEIRNQLELLSDLTLDDGQLAFLERISFLKPDFLRFLR 91
Cdd:TIGR01513 2 LLTDLYELTMAQGYFrEGKANQPAVFEVFFRKLPFGRGYAvfAGLEDLLEFLENFRFDAEDIEYLASLGIFDDAFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 92 LFRFNLRyVRLGIENDQLF-----LRLKGPWLHVILFEVPLLAIIsevrnrHLHPRMRLAEARdqlyrkfdwLRAHANED 166
Cdd:TIGR01513 82 EFRFSGT-VRALPEGSLVFpneplLQVEGPLIEAQLLETLVLNII------NFQTLIATKAAR---------IVLAAGGK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 167 ELAElqvadFGTRRrfsSRVQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHqqlgprliDSQIAALD 246
Cdd:TIGR01513 146 PLLE-----FGLRR---AQGPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF--------DNELAAFR 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 247 CWVREY----RGL------LGIALTDCITMDAFLGDfdlyfAKLFDGLRHDSGEPVAWAEKAIAHYQKLGIdPMTKTLVf 316
Cdd:TIGR01513 210 AYAKLYpkatVLLvdtydtLRSGLPNAIAVAKELGE-----QGKVVGVRIDSGDLLYLSKQARKQLDAAGL-TQVKIVV- 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505084887 317 SDGLNLTrSLEIFRALRGRINVsFGIGTNL-TCdiPGVAPMSIVLKMTDCNGAPVAKISDEAAKT 380
Cdd:TIGR01513 283 SNDLDEN-SIAALKAEGAPIDV-YGVGTSLvTA--SDAPALGGVYKLVAYEGRPVMKLSENPEKS 343
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
15-362 |
8.25e-12 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 65.67 E-value: 8.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 15 LDTDFYKLTMMQGVLH-NYPDADVEWEFRCRNGEDLRPYL--GEIRNQLELLSDLTLDDGQLAFLERISFLKPDFLRFLR 91
Cdd:cd01570 2 LLTDLYQLTMAQAYWKeGKHNKPAVFELFFRKLPFGGGYAvfAGLEELLEYLENFRFTEEDIDYLRSLGIFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 92 LFRFNLRyVRLGIENDQLF-----LRLKGPWLHVILFEVPLLAIISevrnrhlHP--------RMRLAeardqlyrkfdw 158
Cdd:cd01570 82 GFRFTGT-IYAIPEGEVVFpneplLTVEGPLIEAQLLETLLLNLIN-------FQtliatkaaRVRLA------------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 159 lrahanedeLAELQVADFGTRRRFSsrvQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAHqqlgprli 238
Cdd:cd01570 142 ---------AGGRPLLEFGLRRAQG---PDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF-------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 239 DSQIAALDCWVREYRGLLgIALTDciTMD-----------AFLGDFDLYFaKLFdGLRHDSGEPVAWAEKAIAHYQKLGI 307
Cdd:cd01570 202 DDELAAFRAFAEAYPDNF-TLLVD--TYDtlrsglpnaiaVAKELGALGY-RLV-GVRIDSGDLAYLSKEARKMLDEAGL 276
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 505084887 308 DPMtkTLVFSDGLNlTRSLEIFRALRGRINVsFGIGTNL-TCdiPGVAPMSIVLKM 362
Cdd:cd01570 277 TKV--KIVASNDLD-EYTIAALNAQGAPIDA-FGVGTRLvTS--QSQPALGGVYKL 326
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
15-376 |
2.56e-09 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 58.60 E-value: 2.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 15 LDTDFYKLTMMQGVLHNYPDADVEWEFRCRNGEDLRPYL--GEIRNQLELLSDLTLDDGQLAFLeRISFLKPDFLRFLRL 92
Cdd:PRK12484 6 LLTDLYEVTMANAYLREGMSAPATFSLFYRKLPDGRGFLiaAGLADVVEFLEAFRFDEQDLRYL-RGLNQFSEEFLAWLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 93 FRFNLRYVRLGIEN-----DQLFLRLKGPWLHVILFEVPLLAIISevrnrhlHP--------RMRLAeARDQlyrkfdwl 159
Cdd:PRK12484 85 GLRFTGDVRAVPEGtvvfpNEPLLEVTAPLIEAQLVETFLLNQIN-------HQsliaskaaRCVLA-AAGR-------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 160 rahanedelaelQVADFGTRRrfsSRVQEEVVRVLRDDFPGRFVGTSNVDLAWKLDIKPLGTMAHEWIMAhqqlgprlID 239
Cdd:PRK12484 149 ------------PVVDFGARR---AHGTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEA--------FP 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 240 SQIAALDCWVREYRGLLgIALTDciTMDAFLG---------DFDLYFAKLfdGLRHDSGEPVAWAEKAIAHYQKLGIdPM 310
Cdd:PRK12484 206 DEVAAFRAFARLYPDAT-TLLVD--TYDTLRGvrnaievakELGNRFDPR--GVRLDSGDLAELSKATRAILDAAGL-EQ 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 311 TKtLVFSDGLNLTRSLEIFRAlRGRINVsFGIGTNLtcdipGV---AP-MSIVLKMTDCNGAPVAKISDE 376
Cdd:PRK12484 280 VK-IVASGGLDEYRIAALLAA-GAPIDG-FGVGTRL-----GVaadAPvLDSAYKLVAYEGRGVTKLSSG 341
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
15-252 |
1.68e-07 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 52.85 E-value: 1.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 15 LDTDFYKLTMMQGVL----HNYPdADVEWEFRcRNGEDlRPY-----LGEIrnqLELLSDLTLDDGQLAFLERISFLKPD 85
Cdd:PRK09243 11 LLTDLYELTMAQAYLrdgiHNRR-AVFELFFR-KLPFG-RGYavfagLERL---LEYLENLRFTEEDIEYLRSLGIFDED 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 86 FLRFLRLFrfnlryvRLGI------ENDQLF-----LRLKGPWLHVILFEVPLLAIIsevrNrhlHP--------RMRLA 146
Cdd:PRK09243 85 FLDYLRNF-------RFTGdvravpEGELVFpneplLRVEGPLAEAQLLETLLLNII----N---FQtliatkaaRIVSA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505084887 147 eARDQLyrkfdwlrahanedelaelqVADFGTRrrfssRVQEEVVRVL--RDDFPGRFVGTSNVDLAWKLDIKPLGTMAH 224
Cdd:PRK09243 151 -AGGRP--------------------LLEFGSR-----RAQGPDAAVWaaRAAYIGGFDATSNVLAGKRYGIPVSGTMAH 204
|
250 260
....*....|....*....|....*...
gi 505084887 225 EWIMAHqqlgprliDSQIAALDCWVREY 252
Cdd:PRK09243 205 SFVQAF--------DDEYEAFRAYAETY 224
|
|
| |
