|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10551 |
PRK10551 |
cyclic di-GMP phosphodiesterase; |
1-515 |
0e+00 |
|
cyclic di-GMP phosphodiesterase;
Pssm-ID: 182541 [Multi-domain] Cd Length: 518 Bit Score: 938.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 1 MLTRYFASHRKILFFSIITGLIAAILLGSLQFFWSYHKREIRFDTLIKDVSIYMENYFEELKTSIDVLQPLTLNNCQDVN 80
Cdd:PRK10551 1 MFTRAPSSGRKILLTSIVAGVMIALLFSCLQFLLLWHKREVKYDTLITDVQKYLDTYFADLKSTTDRLQPLTLDTCQQVN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 81 AELTSRAAFSINVRAFLLVRNKMAFCSSATGPMNTPMEELIPELHINKQIDIALLPGTPMLPNRPAIAIWYRNPLVKDGG 160
Cdd:PRK10551 81 PELTSRAAFSLNVRAFLLVKDKKAFCSSATGEMNTPLSELIPAIDINKPVDMAILPGTPMMPNKPAIVIWYRNPLLKNSG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 161 VFTSVNLNLTPYLLYTARQEEFAGIAIIIGDNALSTASSTLVRARDLHQTPARTATLTEVPLTIKLYAREWTSDEILFAL 240
Cdd:PRK10551 161 VFATLNLNLTPYLLYTSRQEDFDGIALIIGNTALSTFSSRLMNVNELPDMPLRETTIPGYPLTIRLYADSWTANDIWYAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 241 FFGLLCGIAAGSLNFYILTLRLNPGKEILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEA 320
Cdd:PRK10551 241 LLGLLSGILVGLLCYYLLSLRMRPGKEILTGIKRGQFYVEYQPVVDTQTLRVTGLEALLRWRHPTAGEIPPDAFINYAEA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 321 QKLIVPLTLHLFDLIIRDAPVLQTVLPPGAKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEITERDMLNHREAS 400
Cdd:PRK10551 321 QKLIVPLTQHLFELIARDAAELQKVLPVGAKLGINISPAHLHSDSFKADVQRLLASLPADHFQIVLEITERDMVQEEEAT 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 401 SLFEWLHNEGFEIAIDDFGTGHSALIYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQ 480
Cdd:PRK10551 401 KLFAWLHSQGIEIAIDDFGTGHSALIYLERFTLDYLKIDRGFIQAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQ 480
|
490 500 510
....*....|....*....|....*....|....*
gi 504697483 481 AAWLREHGVHFLQGYWISRPMPLEQFRTWQNKVSS 515
Cdd:PRK10551 481 ARWLRERGVNFLQGYWISRPLPLEDFVRWLKEPYT 515
|
|
| YjcC |
COG4943 |
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ... |
9-509 |
9.24e-109 |
|
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];
Pssm-ID: 443970 [Multi-domain] Cd Length: 528 Bit Score: 333.81 E-value: 9.24e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 9 HRKILFFSIITGLIAAIL--LGSLQFFWSYHKREIRF--DTLIKDVSIYMENYFEELKTSIDVLQPLTLNNCQDVNAELT 84
Cdd:COG4943 5 RRRLLSLATLLALLAALLplLLSLWLAQIQARRREREqlESYAQRALARAERVFDQARSALDELNALPGDPCSPAHLAAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 85 SRAAFSI-NVRAFLLVRNKMAFCSSAtGPMNTPMEELIPELHINKQIDIALLPGTPMLPNRPAIAIWYRNPLVK-DGGVF 162
Cdd:COG4943 85 RRLVFSSrYVRDIGYVRDGRLLCSSL-GKLSKPVPLPPPDYVTADGYRLWLNVDNPLDPGRPMLIVGRGNYVVViDPAAF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 163 TSVNLNLTPY---LLYTARQEEFAGIaiiigDNALSTASSTLVRARD--LHQTPARTATLTEVPLTIKLYARE------- 230
Cdd:COG4943 164 IDVLSPQPGIslaLLATNGGHLFASS-----GNPDPALLSRLLRGPSswFIQGDRLYASACSPQYPICVVAAAplaglla 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 231 -WTsDEILFALFFGLLCGIAAGSLNFYILTLRLNPGKEILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEI 309
Cdd:COG4943 239 lWR-QLLLLLLPLGLLLSLLLGLLVLRLLRRRLSPRRRLRRAIKRREFYVHYQPIVDLKTGRCVGAEALVRWRDPDGSVI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 310 PPDAFINFAEAQKLIVPLTLHLFDLIIRD-APVLQTvlPPGAKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEI 388
Cdd:COG4943 318 SPDIFIPLAEQSGLISPLTRQVIEQVFRDlGDLLAA--DPDFHISINLSASDLLSPRFLDDLERLLARTGVAPQQIVLEI 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 389 TERDMLNHREASSLFEWLHNEGFEIAIDDFGTGHSALIYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNM 468
Cdd:COG4943 396 TERGFIDPAKARAVIAALREAGHRIAIDDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMAKTLNL 475
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 504697483 469 LTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPLEQFRTW 509
Cdd:COG4943 476 DVVAEGVETEEQADYLRARGVQYGQGWLFAKPLPAEEFIAW 516
|
|
| EAL |
smart00052 |
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ... |
267-505 |
4.60e-87 |
|
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.
Pssm-ID: 214491 [Multi-domain] Cd Length: 242 Bit Score: 267.93 E-value: 4.60e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 267 EILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDAPVLQTVL 346
Cdd:smart00052 3 ELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQAQG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 347 PPGAKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEITERDMLNH-REASSLFEWLHNEGFEIAIDDFGTGHSAL 425
Cdd:smart00052 83 PPPLLISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDdESAVATLQRLRELGVRIALDDFGTGYSSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 426 IYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPLEQ 505
Cdd:smart00052 163 SYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPLPLDD 242
|
|
| EAL |
cd01948 |
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ... |
267-505 |
2.68e-84 |
|
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.
Pssm-ID: 238923 [Multi-domain] Cd Length: 240 Bit Score: 260.94 E-value: 2.68e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 267 EILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDAPVLQTVL 346
Cdd:cd01948 2 DLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQAGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 347 PPGaKLGINIAPGHLHAESFKDDMRTF--KSLLPPDyfQIVLEITERDMLNHRE-ASSLFEWLHNEGFEIAIDDFGTGHS 423
Cdd:cd01948 82 PDL-RLSVNLSARQLRDPDFLDRLLELlaETGLPPR--RLVLEITESALIDDLEeALATLRRLRALGVRIALDDFGTGYS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 424 ALIYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPL 503
Cdd:cd01948 159 SLSYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPA 238
|
..
gi 504697483 504 EQ 505
Cdd:cd01948 239 EE 240
|
|
| EAL |
pfam00563 |
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ... |
267-500 |
2.87e-71 |
|
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.
Pssm-ID: 425752 [Multi-domain] Cd Length: 235 Bit Score: 226.82 E-value: 2.87e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 267 EILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDapVLQTVL 346
Cdd:pfam00563 3 ALRRALENGEFVLYYQPIVDLRTGRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALAD--LAQLQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 347 PPGAKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEITERDMLNHRE-ASSLFEWLHNEGFEIAIDDFGTGHSAL 425
Cdd:pfam00563 81 GPDIKLSINLSPASLADPGFLELLRALLKQAGPPPSRLVLEITESDLLARLEaLREVLKRLRALGIRIALDDFGTGYSSL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504697483 426 IYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRP 500
Cdd:pfam00563 161 SYLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRELGCDLVQGYYFSKP 235
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10551 |
PRK10551 |
cyclic di-GMP phosphodiesterase; |
1-515 |
0e+00 |
|
cyclic di-GMP phosphodiesterase;
Pssm-ID: 182541 [Multi-domain] Cd Length: 518 Bit Score: 938.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 1 MLTRYFASHRKILFFSIITGLIAAILLGSLQFFWSYHKREIRFDTLIKDVSIYMENYFEELKTSIDVLQPLTLNNCQDVN 80
Cdd:PRK10551 1 MFTRAPSSGRKILLTSIVAGVMIALLFSCLQFLLLWHKREVKYDTLITDVQKYLDTYFADLKSTTDRLQPLTLDTCQQVN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 81 AELTSRAAFSINVRAFLLVRNKMAFCSSATGPMNTPMEELIPELHINKQIDIALLPGTPMLPNRPAIAIWYRNPLVKDGG 160
Cdd:PRK10551 81 PELTSRAAFSLNVRAFLLVKDKKAFCSSATGEMNTPLSELIPAIDINKPVDMAILPGTPMMPNKPAIVIWYRNPLLKNSG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 161 VFTSVNLNLTPYLLYTARQEEFAGIAIIIGDNALSTASSTLVRARDLHQTPARTATLTEVPLTIKLYAREWTSDEILFAL 240
Cdd:PRK10551 161 VFATLNLNLTPYLLYTSRQEDFDGIALIIGNTALSTFSSRLMNVNELPDMPLRETTIPGYPLTIRLYADSWTANDIWYAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 241 FFGLLCGIAAGSLNFYILTLRLNPGKEILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEA 320
Cdd:PRK10551 241 LLGLLSGILVGLLCYYLLSLRMRPGKEILTGIKRGQFYVEYQPVVDTQTLRVTGLEALLRWRHPTAGEIPPDAFINYAEA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 321 QKLIVPLTLHLFDLIIRDAPVLQTVLPPGAKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEITERDMLNHREAS 400
Cdd:PRK10551 321 QKLIVPLTQHLFELIARDAAELQKVLPVGAKLGINISPAHLHSDSFKADVQRLLASLPADHFQIVLEITERDMVQEEEAT 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 401 SLFEWLHNEGFEIAIDDFGTGHSALIYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQ 480
Cdd:PRK10551 401 KLFAWLHSQGIEIAIDDFGTGHSALIYLERFTLDYLKIDRGFIQAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQ 480
|
490 500 510
....*....|....*....|....*....|....*
gi 504697483 481 AAWLREHGVHFLQGYWISRPMPLEQFRTWQNKVSS 515
Cdd:PRK10551 481 ARWLRERGVNFLQGYWISRPLPLEDFVRWLKEPYT 515
|
|
| YjcC |
COG4943 |
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ... |
9-509 |
9.24e-109 |
|
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];
Pssm-ID: 443970 [Multi-domain] Cd Length: 528 Bit Score: 333.81 E-value: 9.24e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 9 HRKILFFSIITGLIAAIL--LGSLQFFWSYHKREIRF--DTLIKDVSIYMENYFEELKTSIDVLQPLTLNNCQDVNAELT 84
Cdd:COG4943 5 RRRLLSLATLLALLAALLplLLSLWLAQIQARRREREqlESYAQRALARAERVFDQARSALDELNALPGDPCSPAHLAAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 85 SRAAFSI-NVRAFLLVRNKMAFCSSAtGPMNTPMEELIPELHINKQIDIALLPGTPMLPNRPAIAIWYRNPLVK-DGGVF 162
Cdd:COG4943 85 RRLVFSSrYVRDIGYVRDGRLLCSSL-GKLSKPVPLPPPDYVTADGYRLWLNVDNPLDPGRPMLIVGRGNYVVViDPAAF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 163 TSVNLNLTPY---LLYTARQEEFAGIaiiigDNALSTASSTLVRARD--LHQTPARTATLTEVPLTIKLYARE------- 230
Cdd:COG4943 164 IDVLSPQPGIslaLLATNGGHLFASS-----GNPDPALLSRLLRGPSswFIQGDRLYASACSPQYPICVVAAAplaglla 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 231 -WTsDEILFALFFGLLCGIAAGSLNFYILTLRLNPGKEILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEI 309
Cdd:COG4943 239 lWR-QLLLLLLPLGLLLSLLLGLLVLRLLRRRLSPRRRLRRAIKRREFYVHYQPIVDLKTGRCVGAEALVRWRDPDGSVI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 310 PPDAFINFAEAQKLIVPLTLHLFDLIIRD-APVLQTvlPPGAKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEI 388
Cdd:COG4943 318 SPDIFIPLAEQSGLISPLTRQVIEQVFRDlGDLLAA--DPDFHISINLSASDLLSPRFLDDLERLLARTGVAPQQIVLEI 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 389 TERDMLNHREASSLFEWLHNEGFEIAIDDFGTGHSALIYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNM 468
Cdd:COG4943 396 TERGFIDPAKARAVIAALREAGHRIAIDDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMAKTLNL 475
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 504697483 469 LTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPLEQFRTW 509
Cdd:COG4943 476 DVVAEGVETEEQADYLRARGVQYGQGWLFAKPLPAEEFIAW 516
|
|
| EAL |
smart00052 |
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ... |
267-505 |
4.60e-87 |
|
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.
Pssm-ID: 214491 [Multi-domain] Cd Length: 242 Bit Score: 267.93 E-value: 4.60e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 267 EILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDAPVLQTVL 346
Cdd:smart00052 3 ELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQAQG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 347 PPGAKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEITERDMLNH-REASSLFEWLHNEGFEIAIDDFGTGHSAL 425
Cdd:smart00052 83 PPPLLISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDdESAVATLQRLRELGVRIALDDFGTGYSSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 426 IYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPLEQ 505
Cdd:smart00052 163 SYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPLPLDD 242
|
|
| EAL |
cd01948 |
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ... |
267-505 |
2.68e-84 |
|
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.
Pssm-ID: 238923 [Multi-domain] Cd Length: 240 Bit Score: 260.94 E-value: 2.68e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 267 EILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDAPVLQTVL 346
Cdd:cd01948 2 DLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQAGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 347 PPGaKLGINIAPGHLHAESFKDDMRTF--KSLLPPDyfQIVLEITERDMLNHRE-ASSLFEWLHNEGFEIAIDDFGTGHS 423
Cdd:cd01948 82 PDL-RLSVNLSARQLRDPDFLDRLLELlaETGLPPR--RLVLEITESALIDDLEeALATLRRLRALGVRIALDDFGTGYS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 424 ALIYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPL 503
Cdd:cd01948 159 SLSYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPA 238
|
..
gi 504697483 504 EQ 505
Cdd:cd01948 239 EE 240
|
|
| COG5001 |
COG5001 |
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain ... |
271-509 |
4.83e-75 |
|
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms];
Pssm-ID: 444025 [Multi-domain] Cd Length: 678 Bit Score: 250.08 E-value: 4.83e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 271 AIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDAPVLQTVLPPGA 350
Cdd:COG5001 433 ALERGELELHYQPQVDLATGRIVGAEALLRWQHPERGLVSPAEFIPLAEETGLIVPLGEWVLREACRQLAAWQDAGLPDL 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 351 KLGINIAPGHLHAESFKDDMRTF--KSLLPPDyfQIVLEITERDMLNHRE-ASSLFEWLHNEGFEIAIDDFGTGHSALIY 427
Cdd:COG5001 513 RVAVNLSARQLRDPDLVDRVRRAlaETGLPPS--RLELEITESALLEDPEeALETLRALRALGVRIALDDFGTGYSSLSY 590
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 428 LEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPLEQFR 507
Cdd:COG5001 591 LKRLPVDTLKIDRSFVRDLAEDPDDAAIVRAIIALAHSLGLEVVAEGVETEEQLEFLRELGCDYAQGYLFSRPLPAEELE 670
|
..
gi 504697483 508 TW 509
Cdd:COG5001 671 AL 672
|
|
| EAL |
COG2200 |
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) ... |
266-509 |
1.05e-74 |
|
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms];
Pssm-ID: 441802 [Multi-domain] Cd Length: 576 Bit Score: 246.62 E-value: 1.05e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 266 KEILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDAPVLQTV 345
Cdd:COG2200 331 SELREALEEGELRLYYQPIVDLRTGRVVGYEALLRWRHPDGGLISPAEFIPAAERSGLIVELDRWVLERALRQLARWPER 410
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 346 LPPGaKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEITERDMLNHRE-ASSLFEWLHNEGFEIAIDDFGTGHSA 424
Cdd:COG2200 411 GLDL-RLSVNLSARSLLDPDFLERLLELLAEYGLPPERLVLEITESALLEDLEaAIELLARLRALGVRIALDDFGTGYSS 489
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 425 LIYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPLE 504
Cdd:COG2200 490 LSYLKRLPPDYLKIDRSFVRDIARDPRDQAIVRAIVALAHRLGLKVVAEGVETEEQLEALRELGCDYAQGYLFGRPLPLE 569
|
....*
gi 504697483 505 QFRTW 509
Cdd:COG2200 570 ELEAL 574
|
|
| EAL |
pfam00563 |
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ... |
267-500 |
2.87e-71 |
|
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.
Pssm-ID: 425752 [Multi-domain] Cd Length: 235 Bit Score: 226.82 E-value: 2.87e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 267 EILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDapVLQTVL 346
Cdd:pfam00563 3 ALRRALENGEFVLYYQPIVDLRTGRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALAD--LAQLQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 347 PPGAKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEITERDMLNHRE-ASSLFEWLHNEGFEIAIDDFGTGHSAL 425
Cdd:pfam00563 81 GPDIKLSINLSPASLADPGFLELLRALLKQAGPPPSRLVLEITESDLLARLEaLREVLKRLRALGIRIALDDFGTGYSSL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504697483 426 IYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRP 500
Cdd:pfam00563 161 SYLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRELGCDLVQGYYFSKP 235
|
|
| PRK10060 |
PRK10060 |
cyclic di-GMP phosphodiesterase; |
271-509 |
1.19e-40 |
|
cyclic di-GMP phosphodiesterase;
Pssm-ID: 236645 [Multi-domain] Cd Length: 663 Bit Score: 155.61 E-value: 1.19e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 271 AIKRGQFYVVYQPVVDTDAlQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHlfdliirdapVLQTVLPPGA 350
Cdd:PRK10060 416 ALENDQLVIHYQPKITWRG-EVRSLEALVRWQSPERGLIPPLEFISYAEESGLIVPLGRW----------VMLDVVRQVA 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 351 K-----LGINIAPgHLHAESFKDD--MRTFKSLLPP---DYFQIVLEITERDML-NHREASSLFEWLHNEGFEIAIDDFG 419
Cdd:PRK10060 485 KwrdkgINLRVAV-NVSARQLADQtiFTALKQALQElnfEYCPIDVELTESCLIeNEELALSVIQQFSQLGAQVHLDDFG 563
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 420 TGHSALIYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISR 499
Cdd:PRK10060 564 TGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVETAKEDAFLTKNGVNERQGFLFAK 643
|
250
....*....|
gi 504697483 500 PMPLEQFRTW 509
Cdd:PRK10060 644 PMPAVAFERW 653
|
|
| PRK11829 |
PRK11829 |
biofilm formation regulator HmsP; Provisional |
261-506 |
3.55e-36 |
|
biofilm formation regulator HmsP; Provisional
Pssm-ID: 183329 [Multi-domain] Cd Length: 660 Bit Score: 142.39 E-value: 3.55e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 261 RLNPGKEILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIR--- 337
Cdd:PRK11829 403 RLTQENDLLQAIENHDFTLFLQPQWDMKRQQVIGAEALLRWCQPDGSYVLPSGFVHFAEEEGMMVPLGNWVLEEACRila 482
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 338 DAPVLQTVLPpgakLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEITERDMLNH-REASSLFEWLHNEGFEIAID 416
Cdd:PRK11829 483 DWKARGVSLP----LSVNISGLQVQNKQFLPHLKTLISHYHIDPQQLLLEITETAQIQDlDEALRLLRELQGLGLLIALD 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 417 DFGTGHSALIYLEHFT---MDYLKIDRGFVNAIGTETVTSPVLDAVltlARKLNMLTVAEGVETPEQAAWLREHGVHFLQ 493
Cdd:PRK11829 559 DFGIGYSSLRYLNHLKslpIHMIKLDKSFVKNLPEDDAIARIISCV---SDVLKVRVMAEGVETEEQRQWLLEHGIQCGQ 635
|
250
....*....|...
gi 504697483 494 GYWISRPMPLEQF 506
Cdd:PRK11829 636 GFLFSPPLPRAEF 648
|
|
| PRK13561 |
PRK13561 |
putative diguanylate cyclase; Provisional |
261-506 |
5.56e-35 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 184143 [Multi-domain] Cd Length: 651 Bit Score: 139.08 E-value: 5.56e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 261 RLNPGKEILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDAP 340
Cdd:PRK13561 398 RLTEESDILNALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDLPEGLIDRIESCGLMVTVGHWVLEESCRLLA 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 341 VLQ---TVLPpgakLGINIAPGHLHAESFKDDMrtfKSLLppDYFQI-----VLEITE-RDMLNHREASSLFEWLHNEGF 411
Cdd:PRK13561 478 AWQergIMLP----LSVNLSALQLMHPNMVADM---LELL--TRYRIqpgtlILEVTEsRRIDDPHAAVAILRPLRNAGV 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 412 EIAIDDFGTGHSALIYLEHFT---MDYLKIDRGFVNAIGTEtvtSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHG 488
Cdd:PRK13561 549 RVALDDFGMGYAGLRQLQHMKslpIDVLKIDKMFVDGLPED---DSMVAAIIMLAQSLNLQVIAEGVETEAQRDWLLKAG 625
|
250
....*....|....*...
gi 504697483 489 VHFLQGYWISRPMPLEQF 506
Cdd:PRK13561 626 VGIAQGFLFARALPIEIF 643
|
|
| CSS-motif |
pfam12792 |
CSS motif domain associated with EAL; This family with its characteriztic highly conserved CSS ... |
42-232 |
1.23e-33 |
|
CSS motif domain associated with EAL; This family with its characteriztic highly conserved CSS sequence motif is found N-terminal to the EAL, pfam00563, domain in many cyclic diguanylate phosphodiesterases.
Pssm-ID: 463709 Cd Length: 209 Bit Score: 126.49 E-value: 1.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 42 RFDTLIKDVSIYMENYFEELKTSIDVLQPLTLNNCQDVN-AELTSRAAFSINVRAFLLVRNKMAFCSSATGPMNTPMEEL 120
Cdd:pfam12792 4 QLDAFAERALRRLESVLDQADQALDRLLPLTGQPCSPAHlAELRRIVAFSPYVRDVGLVKNGRLYCSSLWGELDTPLPLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 121 IPELHINKQIDIALLPGTPMLPNRPAIAIWYRNPLVK-DGGVFtsVNLNLTPYLLYTARQEEFAGIAIIIGDNALStASS 199
Cdd:pfam12792 84 PPDLTTPPGVRLWLLRGTPLVPGRPALVLRRGGYGVViDPGVF--IDVQYLPGLLAAVSQPDGRLLALVVGDDALL-FDG 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 504697483 200 TLVRARDLHQTPAR-------TATLTEVPLTIKLYAREWT 232
Cdd:pfam12792 161 RLHSLAEPAPGTARsggalyaRARSTRYPLTVVVYAPRAS 200
|
|
| PRK11359 |
PRK11359 |
cyclic-di-GMP phosphodiesterase; Provisional |
261-514 |
1.84e-33 |
|
cyclic-di-GMP phosphodiesterase; Provisional
Pssm-ID: 183097 [Multi-domain] Cd Length: 799 Bit Score: 134.90 E-value: 1.84e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 261 RLNPGKEILSAIKRGQFYVVYQPVVDTDALQMRGVEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDAP 340
Cdd:PRK11359 541 RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEEIGEIENIGRWVIAEACRQLA 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 341 VLQTVLPPGAKLGINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEITERDMLNH-REASSLFEWLHNEGFEIAIDDFG 419
Cdd:PRK11359 621 EWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMQAWGIDGHQLTVEITESMMMEHdTEIFKRIQILRDMGVGLSVDDFG 700
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 420 TGHSALIYLEHFTMDYLKIDRGFVNAIGTETVTSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISR 499
Cdd:PRK11359 701 TGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR 780
|
250
....*....|....*
gi 504697483 500 PMPLEQFRTWQNKVS 514
Cdd:PRK11359 781 PLPAEEIPGWMSSVL 795
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
295-506 |
1.53e-19 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 92.43 E-value: 1.53e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 295 VEVLMRWKHPTMGEIPPDAFINFAEAQKLIVPLTLHLFDLIIRDAPvlQTVLPPGAKLGINIAPGHLHAESFKDDM--RT 372
Cdd:PRK09776 873 WLISLRLWDPEGEIIDEGAFRPAAEDPALMHALDRRVIHEFFRQAA--KAVASKGLSIALPLSVAGLSSPTLLPFLleQL 950
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 373 FKSLLPPDyfQIVLEITERDMLNHRE-ASSLFEWLHNEGFEIAIDDFGTGHSALIYLEHFTMDYLKIDRGFVNAIGTETV 451
Cdd:PRK09776 951 ENSPLPPR--LLHLEITETALLNHAEsASRLVQKLRLAGCRVVLSDFGRGLSSFNYLKAFMADYLKLDGELVANLHGNLM 1028
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 504697483 452 TSPVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPLEQF 506
Cdd:PRK09776 1029 DEMLISIIQGHAQRLGMKTIAGPVELPLVLDTLSGIGVDLAYGYAIARPQPLDLL 1083
|
|
| YuxH |
COG3434 |
c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction ... |
276-505 |
4.58e-13 |
|
c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction mechanisms];
Pssm-ID: 442660 [Multi-domain] Cd Length: 407 Bit Score: 70.99 E-value: 4.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 276 QFYVVYQPVVDTDaLQMRGVEVLMRwkhPTMGEIPPDAFINFAEAQkLIVPLTLHL-FDLIIRDAPVLqtvlppgaklgI 354
Cdd:COG3434 3 DVFVARQPILDRD-QRVVGYELLFR---SGLENSAPDVDGDQATAR-VLLNAFLEIgLDRLLGGKLAF-----------I 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 355 NIAPGHLHAESFkddmrtfkSLLPPDyfQIVLEITERDMLNHREASSLFEwLHNEGFEIAIDDF--GTGHSALIYLehft 432
Cdd:COG3434 67 NFTEELLLSDLP--------ELLPPE--RVVLEILEDVEPDEELLEALKE-LKEKGYRIALDDFvlDPEWDPLLPL---- 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504697483 433 MDYLKIDrgfVNAIGTETvtspvLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPLEQ 505
Cdd:COG3434 132 ADIIKID---VLALDLEE-----LAELVARLKRYGIKLLAEKVETREEFELCKELGFDLFQGYFFSKPEILKG 196
|
|
| PRK11596 |
PRK11596 |
cyclic-di-GMP phosphodiesterase; Provisional |
281-508 |
1.61e-07 |
|
cyclic-di-GMP phosphodiesterase; Provisional
Pssm-ID: 183222 [Multi-domain] Cd Length: 255 Bit Score: 52.70 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 281 YQPVVDTDALQMrGVEVLMRWKHPTMGE--IPPDA-FINFAEAQKL-IVPLTLHLF----DLIIRDapvlqtvlppGAKL 352
Cdd:PRK11596 34 FQPIYRTSGRLM-AIELLTAVTHPSNPSqrLSPERyFAEITVSHRLdVVKEQLDLLaqwaDFFVRH----------GLLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 353 GINIAPGHLHAESFKDDMRTFKSLLPPDYFQIVLEIterDMLNHREASSLFE----WLhnegfeiaiDDFGTG---HSAL 425
Cdd:PRK11596 103 SVNIDGPTLIALRQQPAILRLIERLPWLRFELVEHI---RLPKDSPFASMCEfgplWL---------DDFGTGmanFSAL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697483 426 IYLEHftmDYLKIDRG-FVNAIGTETVTSpVLDAVLTLARKLNMLTVAEGVETPEQAAWLREHGVHFLQGYWISRPMPLE 504
Cdd:PRK11596 171 SEVRY---DYIKVARElFIMLRQSEEGRN-LFSQLLHLMNRYCRGVIVEGVETPEEWRDVQRSPAFAAQGYFLSRPAPFE 246
|
....
gi 504697483 505 QFRT 508
Cdd:PRK11596 247 TLET 250
|
|
| |
