NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|504697442|ref|WP_014884544|]
View 

MULTISPECIES: sensor histidine kinase [Enterobacter]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
335-559 3.41e-70

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 229.37  E-value: 3.41e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 335 LFSSINRTLGEGIAQLLSAQILAGQYERQKALLTQSEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQAAQLVQFLSTFFR 414
Cdd:COG3275  124 LLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLR 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 415 KNLKR-PSEIVTLSDEIEHVNAYLQIEQARFQSRLQVSLSVPDDLAYQHLPAFTLQPIVENAIKHGTSQLLGIGEITIAA 493
Cdd:COG3275  204 YSLYEsDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISI 283

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504697442 494 SRFNHHLVLDIEDNAGLYQPST---SGGLGMSLVDKRLRAHFGDDCGITVACEPDRFTRITVRLPLEEN 559
Cdd:COG3275  284 EVEGDRLVIEVENNGVGIQPKKkkkGSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLKKE 352
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 27-196 4.77e-49

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


:

Pssm-ID: 429599  Cd Length: 170  Bit Score: 167.36  E-value: 4.77e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442   27 TRLFIPLM-QVTVRLPHKLLCYVTFSIFCIMGTYFGLHIE-DSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSMGG 104
Cdd:pfam07694   1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442  105 MTALSCMISTIVEGLLGGLVHSYMIKRGRpdkVFSPLTAGAITFVAEMAQMAIILLIARPFDDALHLVSSIAAPMMVTNT 184
Cdd:pfam07694  81 FTALACGISTILAGLIAGLLHRRLKRRRR---LISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157

                         170
                  ....*....|..
gi 504697442  185 VGAALFMRILLD 196
Cdd:pfam07694 158 LGTAIFLSILRD 169
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 242-353 3.50e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 43.99  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442  242 ELDIGAVAI----TDREKLLAFTGTGDDH-HLPGKPISSTYTLRAIETGEVVYADGNEVPYRCSLHP--QCKLGSTLVIP 314
Cdd:pfam13185  17 ELGASAVGFillvDDDGRLAAWGGAADELsAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKGLPagHAGLRSFLSVP 96

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 504697442  315 LRGENqRVMGTIKLYEAKNRLFSSINRTLGEGIAQLLSA 353
Cdd:pfam13185  97 LVSGG-RVVGVLALGSNRPGAFDEEDLELLELLAEQAAI 134
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
335-559 3.41e-70

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 229.37  E-value: 3.41e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 335 LFSSINRTLGEGIAQLLSAQILAGQYERQKALLTQSEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQAAQLVQFLSTFFR 414
Cdd:COG3275  124 LLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLR 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 415 KNLKR-PSEIVTLSDEIEHVNAYLQIEQARFQSRLQVSLSVPDDLAYQHLPAFTLQPIVENAIKHGTSQLLGIGEITIAA 493
Cdd:COG3275  204 YSLYEsDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISI 283

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504697442 494 SRFNHHLVLDIEDNAGLYQPST---SGGLGMSLVDKRLRAHFGDDCGITVACEPDRFTRITVRLPLEEN 559
Cdd:COG3275  284 EVEGDRLVIEVENNGVGIQPKKkkkGSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLKKE 352
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 27-196 4.77e-49

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 167.36  E-value: 4.77e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442   27 TRLFIPLM-QVTVRLPHKLLCYVTFSIFCIMGTYFGLHIE-DSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSMGG 104
Cdd:pfam07694   1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442  105 MTALSCMISTIVEGLLGGLVHSYMIKRGRpdkVFSPLTAGAITFVAEMAQMAIILLIARPFDDALHLVSSIAAPMMVTNT 184
Cdd:pfam07694  81 FTALACGISTILAGLIAGLLHRRLKRRRR---LISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157

                         170
                  ....*....|..
gi 504697442  185 VGAALFMRILLD 196
Cdd:pfam07694 158 LGTAIFLSILRD 169
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-555 4.01e-39

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 138.34  E-value: 4.01e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 463 LPAFTLQPIVENAIKHGTSQLLGIGEITIAASRFNHHLVLDIEDNAGLYQPST--------SGGLGMSLVDKRLRAHFGD 534
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTlarilirsSNGLGLNLVDKRLRQAFGN 80

                         90       100
                 ....*....|....*....|.
gi 504697442 535 DCGITVACEPDRFTRITVRLP 555
Cdd:cd16956   81 DYGLDIECAPGEGTRITIRLP 101
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 370-448 4.40e-30

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 112.53  E-value: 4.40e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504697442  370 SEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQAAQLVQFLSTFFRKNLKRPSEIVTLSDEIEHVNAYLQIEQARFQSRL 448
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 468-557 1.18e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 61.51  E-value: 1.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442   468 LQPIVENAIKHGTSQllgiGEITIAASRFNHHLVLDIEDN------------------AGLYQPSTSG-GLGMSLVDKRL 528
Cdd:smart00387  10 LSNLLDNAIKYTPEG----GRITVTLERDGDHVEITVEDNgpgippedlekifepffrTDKRSRKIGGtGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*....
gi 504697442   529 RAHFGDdcgITVACEPDRFTRITVRLPLE 557
Cdd:smart00387  86 ELHGGE---ISVESEPGGGTTFTITLPLE 111
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 242-353 3.50e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 43.99  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442  242 ELDIGAVAI----TDREKLLAFTGTGDDH-HLPGKPISSTYTLRAIETGEVVYADGNEVPYRCSLHP--QCKLGSTLVIP 314
Cdd:pfam13185  17 ELGASAVGFillvDDDGRLAAWGGAADELsAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKGLPagHAGLRSFLSVP 96

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 504697442  315 LRGENqRVMGTIKLYEAKNRLFSSINRTLGEGIAQLLSA 353
Cdd:pfam13185  97 LVSGG-RVVGVLALGSNRPGAFDEEDLELLELLAEQAAI 134
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
335-559 3.41e-70

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 229.37  E-value: 3.41e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 335 LFSSINRTLGEGIAQLLSAQILAGQYERQKALLTQSEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQAAQLVQFLSTFFR 414
Cdd:COG3275  124 LLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLR 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 415 KNLKR-PSEIVTLSDEIEHVNAYLQIEQARFQSRLQVSLSVPDDLAYQHLPAFTLQPIVENAIKHGTSQLLGIGEITIAA 493
Cdd:COG3275  204 YSLYEsDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISI 283

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504697442 494 SRFNHHLVLDIEDNAGLYQPST---SGGLGMSLVDKRLRAHFGDDCGITVACEPDRFTRITVRLPLEEN 559
Cdd:COG3275  284 EVEGDRLVIEVENNGVGIQPKKkkkGSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLKKE 352
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
359-559 2.48e-61

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 209.10  E-value: 2.48e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 359 QYERQKALLtQSEIKLLHAQVNPHFLFNALNTLKAVIRR-DSDQAAQLVQFLSTFFRKNLKRPSEIVTLSDEIEHVNAYL 437
Cdd:COG2972  232 VYELELEKK-EAELKALQAQINPHFLFNTLNSIRWLAELeDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 438 QIEQARFQSRLQVSLSVPDDLAYQHLPAFTLQPIVENAIKHGTSQLLGIGEITIAASRFNHHLVLDIEDN---------- 507
Cdd:COG2972  311 EIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNgvgmpeekle 390

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504697442 508 ---AGLYQPSTSGGLGMSLVDKRLRAHFGDDCGITVACEPDRFTRITVRLPLEEN 559
Cdd:COG2972  391 kllEELSSKGEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPLEEE 445
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 27-196 4.77e-49

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 167.36  E-value: 4.77e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442   27 TRLFIPLM-QVTVRLPHKLLCYVTFSIFCIMGTYFGLHIE-DSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSMGG 104
Cdd:pfam07694   1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442  105 MTALSCMISTIVEGLLGGLVHSYMIKRGRpdkVFSPLTAGAITFVAEMAQMAIILLIARPFDDALHLVSSIAAPMMVTNT 184
Cdd:pfam07694  81 FTALACGISTILAGLIAGLLHRRLKRRRR---LISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157

                         170
                  ....*....|..
gi 504697442  185 VGAALFMRILLD 196
Cdd:pfam07694 158 LGTAIFLSILRD 169
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-555 4.01e-39

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 138.34  E-value: 4.01e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 463 LPAFTLQPIVENAIKHGTSQLLGIGEITIAASRFNHHLVLDIEDNAGLYQPST--------SGGLGMSLVDKRLRAHFGD 534
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTlarilirsSNGLGLNLVDKRLRQAFGN 80

                         90       100
                 ....*....|....*....|.
gi 504697442 535 DCGITVACEPDRFTRITVRLP 555
Cdd:cd16956   81 DYGLDIECAPGEGTRITIRLP 101
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 370-448 4.40e-30

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 112.53  E-value: 4.40e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504697442  370 SEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQAAQLVQFLSTFFRKNLKRPSEIVTLSDEIEHVNAYLQIEQARFQSRL 448
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-555 1.28e-29

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 112.15  E-value: 1.28e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 463 LPAFTLQPIVENAIKHGTSQLLGIGEITIAASRFNHHLVLDIEDNAGLYQP---STSG-------GLGMSLVDKRLRAHF 532
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPkvlNILGkkpkegnGIGLYNVHQRLILLF 80

                         90       100
                 ....*....|....*....|...
gi 504697442 533 GDDCGITVACEPDRFTRITVRLP 555
Cdd:cd16924   81 GEDYGIHIASEPDKGTRITFTIP 103
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 468-557 1.18e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 61.51  E-value: 1.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442   468 LQPIVENAIKHGTSQllgiGEITIAASRFNHHLVLDIEDN------------------AGLYQPSTSG-GLGMSLVDKRL 528
Cdd:smart00387  10 LSNLLDNAIKYTPEG----GRITVTLERDGDHVEITVEDNgpgippedlekifepffrTDKRSRKIGGtGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*....
gi 504697442   529 RAHFGDdcgITVACEPDRFTRITVRLPLE 557
Cdd:smart00387  86 ELHGGE---ISVESEPGGGTTFTITLPLE 111
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
393-557 1.09e-10

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 63.00  E-value: 1.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 393 AVIRRDSDQAAQLVQFLSTFFR---KNLKRPSEIVTLSDEIEHVNAYLQiEQARfQSRLQVSLSVPDDLAYQHLPAFTLQ 469
Cdd:COG0642  148 ETILRSADRLLRLINDLLDLSRleaGKLELEPEPVDLAELLEEVVELFR-PLAE-EKGIELELDLPDDLPTVRGDPDRLR 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 470 PI----VENAIKHGTSQllgiGEITIAASRFNHHLVLDIEDN-AGL------------YQPSTSG-----GLGMSLVdKR 527
Cdd:COG0642  226 QVllnlLSNAIKYTPEG----GTVTVSVRREGDRVRISVEDTgPGIppedlerifepfFRTDPSRrgggtGLGLAIV-KR 300

                        170       180       190
                 ....*....|....*....|....*....|.
gi 504697442 528 L-RAHFGDdcgITVACEPDRFTRITVRLPLE 557
Cdd:COG0642  301 IvELHGGT---IEVESEPGKGTTFTVTLPLA 328
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
395-559 8.90e-10

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 59.15  E-value: 8.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 395 IRRDSDQAAQLVQFLSTFFR---KNLKRPSEIVTLSDEIEhvNAYLQIEQARFQSRLQVSLSVPDDLAYQHLPAFTLQPI 471
Cdd:COG2205   59 IRESAERLLRLIEDLLDLSRlesGKLSLELEPVDLAELLE--EAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 472 V----ENAIKHGTSQllgiGEITIAASRFNHHLVLDIEDN-AGL------------YQPSTSG-----GLGMSLVDKRLR 529
Cdd:COG2205  137 LanllDNAIKYSPPG----GTITISARREGDGVRISVSDNgPGIpeeeleriferfYRGDNSRgeggtGLGLAIVKRIVE 212

                        170       180       190
                 ....*....|....*....|....*....|
gi 504697442 530 AHFGDdcgITVACEPDRFTRITVRLPLEEN 559
Cdd:COG2205  213 AHGGT---IWVESEPGGGTTFTVTLPLAES 239
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 468-558 4.95e-09

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 53.91  E-value: 4.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442  468 LQPIVENAIKHGTSQllgiGEITIAASRfNHHLVLDIEDN-------------AGLYQPSTSG----GLGMSLVDKRLRA 530
Cdd:pfam02518  10 LSNLLDNALKHAAKA----GEITVTLSE-GGELTLTVEDNgigippedlprifEPFSTADKRGgggtGLGLSIVRKLVEL 84

                          90       100
                  ....*....|....*....|....*...
gi 504697442  531 HFGDdcgITVACEPDRFTRITVRLPLEE 558
Cdd:pfam02518  85 LGGT---ITVESEPGGGTTVTLTLPLAQ 109
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-555 3.10e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 48.61  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 463 LPAFTLQPIVENAIKHGTSQLLGIGEITI-AASRFNHHLVLDIEDNAGLYQPSTS----------GGLGMSLVDKRLRAH 531
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKIsVKKQLKNRLHIAVEDNGIGISPKVIerveqdempgNKIGLLNVHQRLKLG 80

                         90       100
                 ....*....|....*....|....
gi 504697442 532 FGDdcGITVACEPDRFTRITVRLP 555
Cdd:cd16955   81 YGE--GLHIRSRPDPGTLIAFYIP 102
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
393-559 1.64e-06

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 50.32  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 393 AVIRRDSDQAAQLVQ---FLSTFFRKNLKRPSEIVTLSDEIEHVNAYLQIeQARfQSRLQVSLSVPDDLAY--------- 460
Cdd:COG5002  206 EIILEEAERLSRLVNdllDLSRLESGELKLEKEPVDLAELLEEVVEELRP-LAE-EKGIELELDLPEDPLLvlgdpdrle 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 461 QhlpafTLQPIVENAIKHGTSQllgiGEITIAASRFNHHLVLDIEDN-AGL------------YQ------PSTSG-GLG 520
Cdd:COG5002  284 Q-----VLTNLLDNAIKYTPEG----GTITVSLREEDDQVRISVRDTgIGIpeedlpriferfYRvdksrsRETGGtGLG 354

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 504697442 521 MSLVDKRLRAHFGDdcgITVACEPDRFTRITVRLPLEEN 559
Cdd:COG5002  355 LAIVKHIVEAHGGR---IWVESEPGKGTTFTITLPLARE 390
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 354-559 2.63e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 49.85  E-value: 2.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 354 QILAGQYERQKALltqseIKLLHAQVnpH-FLfNALNTLKAVIR-RDSDQAAQLVQFLStffrKNLKRPSEIVTLSDEIE 431
Cdd:COG3290  177 ERLEEELEGVKEL-----AEALRAQR--HdFR-NHLHTISGLLQlGEYDEALEYIDEIS----EELQELIDSLLSRIGNP 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 432 HVNAYLQ--IEQARfQSRLQVSLSVPDDLAYQHLPAFTLQPI----VENAIKHGTSQLLGIGEITIAASRFNHHLVLDIE 505
Cdd:COG3290  245 VLAALLLgkAARAR-ERGIDLTIDIDSDLPDLPLSDTDLVTIlgnlLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVE 323

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504697442 506 DN---------AGLYQP--STSG----GLGMSLVDKRLRAHFGDdcgITVACEPDRFTRITVRLPLEEN 559
Cdd:COG3290  324 DSgpgipeellEKIFERgfSTKLgegrGLGLALVKQIVEKYGGT---IEVESEEGEGTVFTVRLPKEGE 389
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
394-560 2.19e-05

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 46.76  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 394 VIRRDSDQAAQLV-QFLStfFRKNLKRPSEIVTLSDEIEHVnayLQIEQARFQSRLQVSLSVPDDLayqhlPAFTLQP-- 470
Cdd:COG3852  175 LIIEEADRLNNLVdRLLS--FSRPRPPEREPVNLHEVLERV---LELLRAEAPKNIRIVRDYDPSL-----PEVLGDPdq 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 471 -------IVENAIKHGTSQllgiGEITI----------AASRFNHHLVLDIEDNaG----------LYQP--STSG---G 518
Cdd:COG3852  245 liqvllnLVRNAAEAMPEG----GTITIrtrverqvtlGGLRPRLYVRIEVIDN-GpgipeeildrIFEPffTTKEkgtG 319

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 504697442 519 LGMSLVDKRLRAHFGDdcgITVACEPDRFTRITVRLPLEENA 560
Cdd:COG3852  320 LGLAIVQKIVEQHGGT---IEVESEPGKGTTFRIYLPLEQAE 358
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 393-560 2.20e-05

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 46.88  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 393 AVIRRDSDQAAQLVQFLSTFFR--KNLKRPSEIVTLSDEIehVNAYlqiEQARFQSRLQVSLSVPDDLayqhlPAFTLQP 470
Cdd:COG5000  246 DTIIRQVDRLKRIVDEFLDFARlpEPQLEPVDLNELLREV--LALY---EPALKEKDIRLELDLDPDL-----PEVLADR 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 471 ---------IVENAIKHGTSQllgiGEITIAASRFNHHLVLDIEDN-AG--------LYQP--ST--SG-GLGMSLVDKR 527
Cdd:COG5000  316 dqleqvlinLLKNAIEAIEEG----GEIEVSTRREDGRVRIEVSDNgPGipeevlerIFEPffTTkpKGtGLGLAIVKKI 391

                        170       180       190
                 ....*....|....*....|....*....|...
gi 504697442 528 LRAHFGDdcgITVACEPDRFTRITVRLPLEENA 560
Cdd:COG5000  392 VEEHGGT---IELESRPGGGTTFTIRLPLAEEA 421
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 422-558 2.31e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 47.21  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 422 EIVTLSDEIEHVN--AYLQ-----IEQARFQSRLQVSLSVPDDlayqHLPAFTLQPI-------VENAIKHGTSQLLGiG 487
Cdd:COG3920  348 ELLYQSEDWEGVDlrDYLRellepLRDSYGGRGIRIELDGPDV----ELPADAAVPLglilnelVTNALKHAFLSGEG-G 422

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504697442 488 EITIAASRFNHHLVLDIEDN-AGL---YQPSTSGGLGMSLVD---KRLRAhfgddcgiTVACEPDRFTRITVRLPLEE 558
Cdd:COG3920  423 RIRVSWRREDGRLRLTVSDNgVGLpedVDPPARKGLGLRLIRalvRQLGG--------TLELDRPEGTRVRITFPLAE 492
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 373-556 2.72e-05

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 46.72  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 373 KLLHAQVNPHFLFNALNTlkavIRRDSDQAAQLVQFLSTFFRKNLKRPsEIVTLSDEIEHVnayLQIEQARF-QSRLQVS 451
Cdd:COG4191  169 RRLEDEPDPEELREALER----ILEGAERAAEIVRSLRAFSRRDEEER-EPVDLNELIDEA---LELLRPRLkARGIEVE 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 452 LSVPDDLayqhlPAFTLQP---------IVENAIkHGTSQLLGiGEITIAASRFNHHLVLDIEDNAG---------LYQP 513
Cdd:COG4191  241 LDLPPDL-----PPVLGDPgqleqvllnLLINAI-DAMEEGEG-GRITISTRREGDYVVISVRDNGPgippevlerIFEP 313

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 504697442 514 --ST----SG-GLGMSLVDKRLRAHFGDdcgITVACEPDRFTRITVRLPL 556
Cdd:COG4191  314 ffTTkpvgKGtGLGLSISYGIVEKHGGR---IEVESEPGGGTTFTITLPL 360
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 242-353 3.50e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 43.99  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442  242 ELDIGAVAI----TDREKLLAFTGTGDDH-HLPGKPISSTYTLRAIETGEVVYADGNEVPYRCSLHP--QCKLGSTLVIP 314
Cdd:pfam13185  17 ELGASAVGFillvDDDGRLAAWGGAADELsAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKGLPagHAGLRSFLSVP 96

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 504697442  315 LRGENqRVMGTIKLYEAKNRLFSSINRTLGEGIAQLLSA 353
Cdd:pfam13185  97 LVSGG-RVVGVLALGSNRPGAFDEEDLELLELLAEQAAI 134
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-555 9.08e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 42.03  E-value: 9.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 463 LPAFTLQPIVENAIKHGTSQLLGIGEITIAASRFNHHLVLDIEDNA-----------GLYQPSTSGGLGMSLVD--KRLR 529
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGqgipeerldllGKTTVTSEKGTGTALENlnRRLI 80

                         90       100
                 ....*....|....*....|....*.
gi 504697442 530 AHFGDDCGITVACEPDRFTRITVRLP 555
Cdd:cd16957   81 GLFGSEACLHIESEVHGGTEVWFVIP 106
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
346-558 1.49e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 43.45  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 346 GIAQLLSAQILagqyerqkalltQSEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQAAQLVQFLstffrknlkRPSEI-- 423
Cdd:COG4585   64 GVGQSLSAIKL------------QLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRGL---------RPPALdd 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 424 VTLSDEIEHVnaylqIEQARFQSRLQVSLSVPDDLAyqHLPA-------FTLQPIVENAIKHGTSQllgigEITIAASRF 496
Cdd:COG4585  123 LGLAAALEEL-----AERLLRAAGIRVELDVDGDPD--RLPPevelalyRIVQEALTNALKHAGAT-----RVTVTLEVD 190

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504697442 497 NHHLVLDIEDN-AGL-YQPSTSGGLGMSLVDKRLRAHFGDdcgITVACEPDRFTRITVRLPLEE 558
Cdd:COG4585  191 DGELTLTVRDDgVGFdPEAAPGGGLGLRGMRERAEALGGT---LTIGSAPGGGTRVRATLPLAA 251
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 474-555 2.29e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 37.15  E-value: 2.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 474 NAIKHGtsqllGIGEITIAASRFNHHLVLDIEDN-AGLYQPSTSGGLGMSLVDKRLRAhfgDDCG--ITVACEPDRFTRI 550
Cdd:cd16917   11 NALKHA-----GASRVRVTLSYTADELTLTVVDDgVGFDGPAPPGGGGFGLLGMRERA---ELLGgtLTIGSRPGGGTRV 82


                 ....*
gi 504697442 551 TVRLP 555
Cdd:cd16917   83 TARLP 87
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
471-556 7.22e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 36.81  E-value: 7.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 471 IVENAIKHGTsQLLGIGEITIAASRFNHHLVLDIEDN---------AGLYQPSTSGGLGMSLVDKrlrahFGDDCGITVa 541
Cdd:COG2172   42 AVTNAVRHAY-GGDPDGPVEVELELDPDGLEIEVRDEgpgfdpedlPDPYSTLAEGGRGLFLIRR-----LMDEVEYES- 114

                         90
                 ....*....|....*
gi 504697442 542 cEPDRfTRITVRLPL 556
Cdd:COG2172  115 -DPGG-TTVRLVKRL 127
GAF COG2203
GAF domain [Signal transduction mechanisms];
252-473 8.70e-03

GAF domain [Signal transduction mechanisms];


Pssm-ID: 441805 [Multi-domain]  Cd Length: 712  Bit Score: 39.02  E-value: 8.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 252 DREKLLAFTGTGDDH-HLPGKPISSTYTLRAIETGEVV-----YADGNEVPYRCSLHPQCKLGSTLVIPLRGENqRVMGT 325
Cdd:COG2203  236 DGGELELVAAPGLPEeELGRLPLGEGLAGRALRTGEPVvvndaSTDPRFAPSLRELLLALGIRSLLCVPLLVDG-RLIGV 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697442 326 IKLYEAKNRLFSSINRTLGEGIAQLLSAQILAGQYERQKALLTQSEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQAAQL 405
Cdd:COG2203  315 LALYSKEPRAFTEEDLELLEALADQAAIAIERARLYEALEAALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLL 394

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504697442 406 VQFLSTFFRKNLKRPSEIVTLSDEIEHVNAYLQIEQARFQSRLQVSLSVPDDLAYQHLPAFTLQPIVE 473
Cdd:COG2203  395 LSLLGAELLLLLLDAADLSGLLALEGLLLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAEL 462
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH