NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|504615617|ref|WP_014802719|]
View 

Crp/Fnr family transcriptional regulator [Turneriella parva]

Protein Classification

Crp/Fnr family transcriptional regulator( domain architecture ID 11429533)

Crp/Fnr family transcriptional regulator containing a DNA-binding Crp-like helix-turn-helix (HTH) domain, may bind cyclic nucleotides

CATH:  2.60.120.10|1.10.10.10
Gene Ontology:  GO:0003677|GO:0030552
PubMed:  11407111|14638413

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 179-383 1.33e-23

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


:

Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 97.36  E-value: 1.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617 179 DHYKEIDFTGKTTAVEQDTMLFSEGEMGKEIFVVLSGSVKLMRIVR-GEEFIIDVLGPGELFGEMAFIEDAPRMGTAVTT 257
Cdd:COG0664    7 EELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEdGREQILGFLGPGDFFGELSLLGGEPSPATAEAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617 258 QDSQLIRISPQQLVSSVAE--GVLQKIFENMARRIWFSHQRLIIFKIGDPLVRMYAYLYNLVRNqnlrtrdnsaQDKSYK 335
Cdd:COG0664   87 EDSELLRIPREDLEELLERnpELARALLRLLARRLRQLQERLVSLAFLSAEERLARFLLELADR----------LDGRID 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 504615617 336 FAITLNELKTLCGIMRLKDTTEASFRANDNLIVEEDG-ITIKSRKRLAD 383
Cdd:COG0664  157 LPLTQEEIASYLGLTRETVSRILKKLEKEGLIELERGrITILDREALER 205
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 5-123 7.46e-13

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


:

Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 66.93  E-value: 7.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617   5 KIKDYKAGNTVIIQNAPNPGiFYLVRKGVLAI---DTEHRlnDKVLSRFEAGDSFGLVSALTGHRFLVTIYATTDAQVAE 81
Cdd:COG0664   17 ELRTLKKGEVLFREGDPADH-LYFVLSGLVKLyriSEDGR--EQILGFLGPGDFFGELSLLGGEPSPATAEALEDSELLR 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 504615617  82 IPVSMIGAYLKSQSDLAVKMLRLYSRELRTIQ---LHLSKLDAPE 123
Cdd:COG0664   94 IPREDLEELLERNPELARALLRLLARRLRQLQerlVSLAFLSAEE 138
 
Name Accession Description Interval E-value
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 179-383 1.33e-23

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 97.36  E-value: 1.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617 179 DHYKEIDFTGKTTAVEQDTMLFSEGEMGKEIFVVLSGSVKLMRIVR-GEEFIIDVLGPGELFGEMAFIEDAPRMGTAVTT 257
Cdd:COG0664    7 EELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEdGREQILGFLGPGDFFGELSLLGGEPSPATAEAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617 258 QDSQLIRISPQQLVSSVAE--GVLQKIFENMARRIWFSHQRLIIFKIGDPLVRMYAYLYNLVRNqnlrtrdnsaQDKSYK 335
Cdd:COG0664   87 EDSELLRIPREDLEELLERnpELARALLRLLARRLRQLQERLVSLAFLSAEERLARFLLELADR----------LDGRID 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 504615617 336 FAITLNELKTLCGIMRLKDTTEASFRANDNLIVEEDG-ITIKSRKRLAD 383
Cdd:COG0664  157 LPLTQEEIASYLGLTRETVSRILKKLEKEGLIELERGrITILDREALER 205
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 193-270 6.65e-20

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 83.43  E-value: 6.65e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504615617  193 VEQDTMLFSEGEMGKEIFVVLSGSVKLMRIVR-GEEFIIDVLGPGELFGEMAFIEDAPRMGTAVTTQDSQLIRISPQQL 270
Cdd:pfam00027   4 YKAGEVIFREGDPADSLYIVLSGKVKVYRTLEdGREQILAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIPREDF 82
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 193-270 4.65e-17

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 76.60  E-value: 4.65e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504615617 193 VEQDTMLFSEGEMGKEIFVVLSGSVKLMRIVR-GEEFIIDVLGPGELFGEMAFIEDAPRMGTAVTTQDSQLIRISPQQL 270
Cdd:cd00038   22 FPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEdGREQIVGFLGPGDLFGELALLGNGPRSATVRALTDSELLVLPRSDF 100
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 5-123 7.46e-13

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 66.93  E-value: 7.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617   5 KIKDYKAGNTVIIQNAPNPGiFYLVRKGVLAI---DTEHRlnDKVLSRFEAGDSFGLVSALTGHRFLVTIYATTDAQVAE 81
Cdd:COG0664   17 ELRTLKKGEVLFREGDPADH-LYFVLSGLVKLyriSEDGR--EQILGFLGPGDFFGELSLLGGEPSPATAEALEDSELLR 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 504615617  82 IPVSMIGAYLKSQSDLAVKMLRLYSRELRTIQ---LHLSKLDAPE 123
Cdd:COG0664   94 IPREDLEELLERNPELARALLRLLARRLRQLQerlVSLAFLSAEE 138
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 199-290 1.42e-12

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 63.96  E-value: 1.42e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617   199 LFSEGEMGKEIFVVLSGSVKLMRIVR-GEEFIIDVLGPGELFGEMAFIED--APRMGTAVTTQDSQLIRISPQQLvssva 275
Cdd:smart00100  28 IIRQGDVGDSFYIIVSGEVEVYKVLEdGEEQIVGTLGPGDFFGELALLTNsrRAASAAAVALELATLLRIDFRDF----- 102

                           90
                   ....*....|....*
gi 504615617   276 EGVLQKIFENMARRI 290
Cdd:smart00100 103 LQLLPELPQLLLELL 117
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 1-102 2.84e-10

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 57.34  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617   1 MPEIKIKDYKAGNTVIIQNAPNPGiFYLVRKGVLAIDTEHR-LNDKVLSRFEAGDSFGLVSALTGHRFLVTIYATTDAQV 79
Cdd:cd00038   14 ADALEERRFPAGEVIIRQGDPADS-LYIVLSGSVEVYKLDEdGREQIVGFLGPGDLFGELALLGNGPRSATVRALTDSEL 92

                         90       100
                 ....*....|....*....|...
gi 504615617  80 AEIPVSMIGAYLKSQSDLAVKML 102
Cdd:cd00038   93 LVLPRSDFRRLLQEYPELARRLL 115
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 6-83 4.00e-09

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 53.38  E-value: 4.00e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504615617    6 IKDYKAGNTVIIQNAPnPGIFYLVRKGVLAIDTEHRL-NDKVLSRFEAGDSFGLVSALTGHRFLVTIYATTDAQVAEIP 83
Cdd:pfam00027   1 LRSYKAGEVIFREGDP-ADSLYIVLSGKVKVYRTLEDgREQILAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIP 78
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
197-290 1.10e-05

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 46.13  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617 197 TMLFSEGEMGKEIFVVLSGSVK-LMRIVRGEEFIIDVLGPGELFGEMA-FIEDAPRMGTAVTTQDSQLIRISPQQL--VS 272
Cdd:PRK11753  29 STLIHAGEKAETLYYIVKGSVAvLIKDEEGKEMILSYLNQGDFIGELGlFEEGQERSAWVRAKTACEVAEISYKKFrqLI 108

                         90
                 ....*....|....*...
gi 504615617 273 SVAEGVLQKIFENMARRI 290
Cdd:PRK11753 109 QVNPDILMALSAQMARRL 126
cyc_nuc_ocin TIGR03896
bacteriocin-type transport-associated protein; Members of this protein family are ...
 188-323 8.20e-05

bacteriocin-type transport-associated protein; Members of this protein family are uncharacterized and contain two copies of the cyclic nucleotide-binding domain pfam00027. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. The models describing the transport operon are TIGR03794, TIGR03796, and TIGR03797.


Pssm-ID: 274839 [Multi-domain]  Cd Length: 317  Bit Score: 44.12  E-value: 8.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617  188 GKTTAVEQDTMLFSEGEMGKEIFVVLSGSVKLmRIVRGEE------FIIDVLGPGELFGEMAFIEDAPRMGTAVTTQDSQ 261
Cdd:TIGR03896   8 GHQREIAAGTTLIEEGKAADFLFILLDGTFTV-TTPQPEDnpltraFELARLSRGEIVGEMSLLETRPPVATIKAVPKSR 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504615617  262 LIRISPQQLVSSVAEGVLqkifenmarrIWFSHQRLIIFKIGDPLVRMYAYLY--NLVRNQNLR 323
Cdd:TIGR03896  87 VMSIPVGELAAKLQSDVG----------FAAHFYRAIAIKLALQIQNQNHQLHrrNGADSEPLR 140
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 9-111 6.83e-03

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 36.22  E-value: 6.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617     9 YKAGNTVIIQNAPnPGIFYLVRKGVLAIDTEHRL-NDKVLSRFEAGDSFGLVSALTGHRFLVTIYATTdAQVAEIPVSmi 87
Cdd:smart00100  22 YPAGEVIIRQGDV-GDSFYIIVSGEVEVYKVLEDgEEQIVGTLGPGDFFGELALLTNSRRAASAAAVA-LELATLLRI-- 97

                           90       100
                   ....*....|....*....|....
gi 504615617    88 gAYLKSQSDLAVKMLRLYSRELRT 111
Cdd:smart00100  98 -DFRDFLQLLPELPQLLLELLLEL 120
 
Name Accession Description Interval E-value
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 179-383 1.33e-23

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 97.36  E-value: 1.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617 179 DHYKEIDFTGKTTAVEQDTMLFSEGEMGKEIFVVLSGSVKLMRIVR-GEEFIIDVLGPGELFGEMAFIEDAPRMGTAVTT 257
Cdd:COG0664    7 EELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEdGREQILGFLGPGDFFGELSLLGGEPSPATAEAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617 258 QDSQLIRISPQQLVSSVAE--GVLQKIFENMARRIWFSHQRLIIFKIGDPLVRMYAYLYNLVRNqnlrtrdnsaQDKSYK 335
Cdd:COG0664   87 EDSELLRIPREDLEELLERnpELARALLRLLARRLRQLQERLVSLAFLSAEERLARFLLELADR----------LDGRID 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 504615617 336 FAITLNELKTLCGIMRLKDTTEASFRANDNLIVEEDG-ITIKSRKRLAD 383
Cdd:COG0664  157 LPLTQEEIASYLGLTRETVSRILKKLEKEGLIELERGrITILDREALER 205
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 193-270 6.65e-20

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 83.43  E-value: 6.65e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504615617  193 VEQDTMLFSEGEMGKEIFVVLSGSVKLMRIVR-GEEFIIDVLGPGELFGEMAFIEDAPRMGTAVTTQDSQLIRISPQQL 270
Cdd:pfam00027   4 YKAGEVIFREGDPADSLYIVLSGKVKVYRTLEdGREQILAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIPREDF 82
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 193-270 4.65e-17

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 76.60  E-value: 4.65e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504615617 193 VEQDTMLFSEGEMGKEIFVVLSGSVKLMRIVR-GEEFIIDVLGPGELFGEMAFIEDAPRMGTAVTTQDSQLIRISPQQL 270
Cdd:cd00038   22 FPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEdGREQIVGFLGPGDLFGELALLGNGPRSATVRALTDSELLVLPRSDF 100
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 5-123 7.46e-13

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 66.93  E-value: 7.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617   5 KIKDYKAGNTVIIQNAPNPGiFYLVRKGVLAI---DTEHRlnDKVLSRFEAGDSFGLVSALTGHRFLVTIYATTDAQVAE 81
Cdd:COG0664   17 ELRTLKKGEVLFREGDPADH-LYFVLSGLVKLyriSEDGR--EQILGFLGPGDFFGELSLLGGEPSPATAEALEDSELLR 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 504615617  82 IPVSMIGAYLKSQSDLAVKMLRLYSRELRTIQ---LHLSKLDAPE 123
Cdd:COG0664   94 IPREDLEELLERNPELARALLRLLARRLRQLQerlVSLAFLSAEE 138
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 199-290 1.42e-12

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 63.96  E-value: 1.42e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617   199 LFSEGEMGKEIFVVLSGSVKLMRIVR-GEEFIIDVLGPGELFGEMAFIED--APRMGTAVTTQDSQLIRISPQQLvssva 275
Cdd:smart00100  28 IIRQGDVGDSFYIIVSGEVEVYKVLEdGEEQIVGTLGPGDFFGELALLTNsrRAASAAAVALELATLLRIDFRDF----- 102

                           90
                   ....*....|....*
gi 504615617   276 EGVLQKIFENMARRI 290
Cdd:smart00100 103 LQLLPELPQLLLELL 117
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 1-102 2.84e-10

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 57.34  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617   1 MPEIKIKDYKAGNTVIIQNAPNPGiFYLVRKGVLAIDTEHR-LNDKVLSRFEAGDSFGLVSALTGHRFLVTIYATTDAQV 79
Cdd:cd00038   14 ADALEERRFPAGEVIIRQGDPADS-LYIVLSGSVEVYKLDEdGREQIVGFLGPGDLFGELALLGNGPRSATVRALTDSEL 92

                         90       100
                 ....*....|....*....|...
gi 504615617  80 AEIPVSMIGAYLKSQSDLAVKML 102
Cdd:cd00038   93 LVLPRSDFRRLLQEYPELARRLL 115
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 6-83 4.00e-09

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 53.38  E-value: 4.00e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504615617    6 IKDYKAGNTVIIQNAPnPGIFYLVRKGVLAIDTEHRL-NDKVLSRFEAGDSFGLVSALTGHRFLVTIYATTDAQVAEIP 83
Cdd:pfam00027   1 LRSYKAGEVIFREGDP-ADSLYIVLSGKVKVYRTLEDgREQILAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIP 78
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
197-290 1.10e-05

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 46.13  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617 197 TMLFSEGEMGKEIFVVLSGSVK-LMRIVRGEEFIIDVLGPGELFGEMA-FIEDAPRMGTAVTTQDSQLIRISPQQL--VS 272
Cdd:PRK11753  29 STLIHAGEKAETLYYIVKGSVAvLIKDEEGKEMILSYLNQGDFIGELGlFEEGQERSAWVRAKTACEVAEISYKKFrqLI 108

                         90
                 ....*....|....*...
gi 504615617 273 SVAEGVLQKIFENMARRI 290
Cdd:PRK11753 109 QVNPDILMALSAQMARRL 126
cyc_nuc_ocin TIGR03896
bacteriocin-type transport-associated protein; Members of this protein family are ...
 188-323 8.20e-05

bacteriocin-type transport-associated protein; Members of this protein family are uncharacterized and contain two copies of the cyclic nucleotide-binding domain pfam00027. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. The models describing the transport operon are TIGR03794, TIGR03796, and TIGR03797.


Pssm-ID: 274839 [Multi-domain]  Cd Length: 317  Bit Score: 44.12  E-value: 8.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617  188 GKTTAVEQDTMLFSEGEMGKEIFVVLSGSVKLmRIVRGEE------FIIDVLGPGELFGEMAFIEDAPRMGTAVTTQDSQ 261
Cdd:TIGR03896   8 GHQREIAAGTTLIEEGKAADFLFILLDGTFTV-TTPQPEDnpltraFELARLSRGEIVGEMSLLETRPPVATIKAVPKSR 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504615617  262 LIRISPQQLVSSVAEGVLqkifenmarrIWFSHQRLIIFKIGDPLVRMYAYLY--NLVRNQNLR 323
Cdd:TIGR03896  87 VMSIPVGELAAKLQSDVG----------FAAHFYRAIAIKLALQIQNQNHQLHrrNGADSEPLR 140
cyc_nuc_ocin TIGR03896
bacteriocin-type transport-associated protein; Members of this protein family are ...
 11-270 3.03e-04

bacteriocin-type transport-associated protein; Members of this protein family are uncharacterized and contain two copies of the cyclic nucleotide-binding domain pfam00027. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. The models describing the transport operon are TIGR03794, TIGR03796, and TIGR03797.


Pssm-ID: 274839 [Multi-domain]  Cd Length: 317  Bit Score: 42.57  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617   11 AGNTVIIQNAPNPGIFYLVRKGV---LAIDTEHRLNDKV-LSRFEAGDSFGLVSALTGHRFLVTIYATTDAQVAEIPVSM 86
Cdd:TIGR03896  15 AGTTLIEEGKAADFLFILLDGTFtvtTPQPEDNPLTRAFeLARLSRGEIVGEMSLLETRPPVATIKAVPKSRVMSIPVGE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617   87 IGAYLKSQSDLAVKMLRLYSREL------RTIQLHLSKLdapEDRNITPDILYNLAgkyiEWDKPHyaaralkayIDWAE 160
Cdd:TIGR03896  95 LAAKLQSDVGFAAHFYRAIAIKLalqiqnQNHQLHRRNG---ADSEPLRKVLFIFG----ELHESD---------VAWMM 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617  161 QnegvyldlartrfeevkdhykeidfTGKTTAVEQDTMLFSEGEMGKEIFVVLSGSVKLMRIVRGEEFIIDVLGPGELFG 240
Cdd:TIGR03896 159 A-------------------------SGTPQKLPAGTILIHEGGTVDALYILLYGEASLSISPDGPGREVGSSRRGEILG 213

                         250       260       270
                  ....*....|....*....|....*....|.
gi 504615617  241 EMAFIE-DAPRMGTAVTTQDSQLIRISPQQL 270
Cdd:TIGR03896 214 ETPFLNgSLPGTATVKAIENSVLLAIDKQQL 244
ftrB PRK09392
transcriptional activator FtrB; Provisional
 197-276 3.23e-04

transcriptional activator FtrB; Provisional


Pssm-ID: 181817 [Multi-domain]  Cd Length: 236  Bit Score: 41.93  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617 197 TMLFSEGEMGKEIFVVLSGSVKLMRIVRGEEFIIDVLGPGELFGEMAFIEDAPRMGTAVTTQDSQLIRIsPQQLVSSVAE 276
Cdd:PRK09392  39 TMLITEGEPADFLFVVLDGLVELSASSQDRETTLAILRPVSTFILAAVVLDAPYLMSARTLTRSRVLMI-PAELVREAMS 117
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 9-111 6.83e-03

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 36.22  E-value: 6.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504615617     9 YKAGNTVIIQNAPnPGIFYLVRKGVLAIDTEHRL-NDKVLSRFEAGDSFGLVSALTGHRFLVTIYATTdAQVAEIPVSmi 87
Cdd:smart00100  22 YPAGEVIIRQGDV-GDSFYIIVSGEVEVYKVLEDgEEQIVGTLGPGDFFGELALLTNSRRAASAAAVA-LELATLLRI-- 97

                           90       100
                   ....*....|....*....|....
gi 504615617    88 gAYLKSQSDLAVKMLRLYSRELRT 111
Cdd:smart00100  98 -DFRDFLQLLPELPQLLLELLLEL 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH