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Conserved domains on  [gi|504530029|ref|WP_014717131|]
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MULTISPECIES: sensor histidine kinase [Pseudomonas]

Protein Classification

sensor histidine kinase( domain architecture ID 11467953)

sensor histidine kinase may be part of a two-component regulatory system and function as a protein kinase that phosphorylates a target protein in response to a signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000156|GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 281-625 4.54e-79

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


:

Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 255.11  E-value: 4.54e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 281 VVNDQHAVSYLAQTRPLNDTPWNFTLLTPLNDLRRAAINQGILVAVAFGLVAFLLIAWNERRKVIATRLAAREALQEANS 360
Cdd:COG4191   13 ALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 361 QLERRIAERTADLRASNERLKGQIRERRQAEETLRRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRTLSGNTVRFLE 440
Cdd:COG4191   93 LLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 441 R-GALDTASTNLKTINELIDRMGRITASLRSFARRGDDQGEA-SLGKAVDAAFQVLGARLDSLPLTVHRDFANAQLQI-- 516
Cdd:COG4191  173 DePDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPvDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVlg 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALDAMQAQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGLGLGLTLSA 596
Cdd:COG4191  253 DPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLSISY 332

                        330       340
                 ....*....|....*....|....*....
gi 504530029 597 SLAAATGGSLAVEHPANGGTAFVLNLPLV 625
Cdd:COG4191  333 GIVEKHGGRIEVESEPGGGTTFTITLPLA 361
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 51-302 4.46e-16

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 78.15  E-value: 4.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029   51 IRTLSDNGERQLELHARTVESELSKYTYLPSLLELESSVSQLLADPNQETRktvNDYLEGLNRRSRSRAIYVMDTTGRVL 130
Cdd:pfam02743   4 KEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEEL---AKLESLLRSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  131 ATSNwrDADSYQGEDLSFRAYFQNAVRGQPGRFYGIGS-----TNGEPGYYLAHGLE-EHGKIIGVAVVKVRLEALEERW 204
Cdd:pfam02743  81 ASSD--ESPSYPGLDVSERPWYKEALKGGGGIIWVFSSpypssESGEPVLTIARPIYdDDGEVIGVLVADLDLDTLQELL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  205 QRARL----EAFVSDENGIIILSSDParrlkavRPLSDDTKDRLAHSLQYYWatlnelqplarerlnegtekLTFPANTE 280
Cdd:pfam02743 159 SQIKLgeggYVFIVDSDGRILAHPLG-------KNLRSLLAPFLGKSLADAL--------------------PGSGITEI 211

                         250       260
                  ....*....|....*....|..
gi 504530029  281 VVNDQHaVSYLAQTRPLNDTPW 302
Cdd:pfam02743 212 AVDLDG-EDYLVAYAPIPGTGW 232
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 281-625 4.54e-79

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 255.11  E-value: 4.54e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 281 VVNDQHAVSYLAQTRPLNDTPWNFTLLTPLNDLRRAAINQGILVAVAFGLVAFLLIAWNERRKVIATRLAAREALQEANS 360
Cdd:COG4191   13 ALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 361 QLERRIAERTADLRASNERLKGQIRERRQAEETLRRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRTLSGNTVRFLE 440
Cdd:COG4191   93 LLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 441 R-GALDTASTNLKTINELIDRMGRITASLRSFARRGDDQGEA-SLGKAVDAAFQVLGARLDSLPLTVHRDFANAQLQI-- 516
Cdd:COG4191  173 DePDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPvDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVlg 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALDAMQAQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGLGLGLTLSA 596
Cdd:COG4191  253 DPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLSISY 332

                        330       340
                 ....*....|....*....|....*....
gi 504530029 597 SLAAATGGSLAVEHPANGGTAFVLNLPLV 625
Cdd:COG4191  333 GIVEKHGGRIEVESEPGGGTTFTITLPLA 361
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
395-624 9.46e-30

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 124.31  E-value: 9.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 395 RRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRTLsgntVRFLERGALDTASTN-LKTINELIDRMGRITASLRSFAR 473
Cdd:PRK11360 375 KRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGY----VQIWRQQTSDPPSQEyLSVVLREVDRLNKVIDQLLEFSR 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 474 RGDDQGEA-SLGKAVDAAFQVLGARLDSLPLTVHRDFANA--QLQIDQTRLEQILVNLIGNALDAMQAQAVPQLWLEgQS 550
Cdd:PRK11360 451 PRESQWQPvSLNALVEEVLQLFQTAGVQARVDFETELDNElpPIWADPELLKQVLLNILINAVQAISARGKIRIRTW-QY 529

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504530029 551 GDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPgeQGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:PRK11360 530 SDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA--KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 516-624 6.99e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 102.34  E-value: 6.99e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029   516 IDQTRLEQILVNLIGNALDAMQAQavPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQ---GLGLGL 592
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEG--GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkigGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 504530029   593 TLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:smart00387  79 SIVKKLVELHGGEISVESEPGGGTTFTITLPL 110
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-622 7.02e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 102.15  E-value: 7.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDAMQAQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGLGLGLTLSASLAA 600
Cdd:cd16976    1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVE 80

                         90       100
                 ....*....|....*....|..
gi 504530029 601 ATGGSLAVEHPANGGTAFVLNL 622
Cdd:cd16976   81 EHGGRLSVANEEGAGARFTFDL 102
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 517-624 2.34e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 95.13  E-value: 2.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  517 DQTRLEQILVNLIGNALDAMQAQAVPQLWLEGqsgDGKYRLLVRDNGHGIDPEARKHLFEPFFTT-KPGEQGLGLGLTLS 595
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE---GGELTLTVEDNGIGIPPEDLPRIFEPFSTAdKRGGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*....
gi 504530029  596 ASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTLPL 107
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 51-302 4.46e-16

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 78.15  E-value: 4.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029   51 IRTLSDNGERQLELHARTVESELSKYTYLPSLLELESSVSQLLADPNQETRktvNDYLEGLNRRSRSRAIYVMDTTGRVL 130
Cdd:pfam02743   4 KEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEEL---AKLESLLRSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  131 ATSNwrDADSYQGEDLSFRAYFQNAVRGQPGRFYGIGS-----TNGEPGYYLAHGLE-EHGKIIGVAVVKVRLEALEERW 204
Cdd:pfam02743  81 ASSD--ESPSYPGLDVSERPWYKEALKGGGGIIWVFSSpypssESGEPVLTIARPIYdDDGEVIGVLVADLDLDTLQELL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  205 QRARL----EAFVSDENGIIILSSDParrlkavRPLSDDTKDRLAHSLQYYWatlnelqplarerlnegtekLTFPANTE 280
Cdd:pfam02743 159 SQIKLgeggYVFIVDSDGRILAHPLG-------KNLRSLLAPFLGKSLADAL--------------------PGSGITEI 211

                         250       260
                  ....*....|....*....|..
gi 504530029  281 VVNDQHaVSYLAQTRPLNDTPW 302
Cdd:pfam02743 212 AVDLDG-EDYLVAYAPIPGTGW 232
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 518-624 5.19e-09

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 59.15  E-value: 5.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  518 QTRLEQILVNLIGNALDAMQAQAVP--QLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPG-EQGLGLGLTL 594
Cdd:TIGR02938 385 ELQLRSLFKALVDNAIEAMNIKGWKrrELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGsRKHIGMGLSV 464

                          90       100       110
                  ....*....|....*....|....*....|
gi 504530029  595 SASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:TIGR02938 465 AQEIVADHGGIIDLDDDYSEGCRIIVEFRV 494
PDC1_DGC_like cd12914
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ...
 93-197 1.94e-08

first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350339  Cd Length: 123  Bit Score: 52.77  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  93 LADPNQETRKTVNDYLEGLNRRSRS-RAIYVMDTTGRVLATSNwrdADSYQGEDLSFRAYFQNAVRGQPGRFYG---IGS 168
Cdd:cd12914   17 ARGAASADPAALQALLRRLLARLPEvRSIFVVDADGRVVASSG---PGPAPGLDVSDRDYFQAARAGGGGLFISepvISR 93

                         90       100       110
                 ....*....|....*....|....*....|
gi 504530029 169 TNGEPGYYLAHGLE-EHGKIIGVAVVKVRL 197
Cdd:cd12914   94 VTGKPVIPLSRPIRdADGRFAGVVVASIDL 123
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 281-625 4.54e-79

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 255.11  E-value: 4.54e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 281 VVNDQHAVSYLAQTRPLNDTPWNFTLLTPLNDLRRAAINQGILVAVAFGLVAFLLIAWNERRKVIATRLAAREALQEANS 360
Cdd:COG4191   13 ALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 361 QLERRIAERTADLRASNERLKGQIRERRQAEETLRRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRTLSGNTVRFLE 440
Cdd:COG4191   93 LLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 441 R-GALDTASTNLKTINELIDRMGRITASLRSFARRGDDQGEA-SLGKAVDAAFQVLGARLDSLPLTVHRDFANAQLQI-- 516
Cdd:COG4191  173 DePDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPvDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVlg 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALDAMQAQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGLGLGLTLSA 596
Cdd:COG4191  253 DPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLSISY 332

                        330       340
                 ....*....|....*....|....*....
gi 504530029 597 SLAAATGGSLAVEHPANGGTAFVLNLPLV 625
Cdd:COG4191  333 GIVEKHGGRIEVESEPGGGTTFTITLPLA 361
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 307-623 4.99e-46

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 172.56  E-value: 4.99e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 307 LTPLNDLRRAAINQG---ILVAVAFGLVAFLLIAWNERRKVIATRLAA-REALQE-ANSQLER-----------RIAER- 369
Cdd:COG4192  310 LVALNQETAQLVQQSgilLLAIALLSLLLAVLINYFYVRRRLVKRLNAlSDAMAAiAAGDLDVpipvdgndeigRIARLl 389

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 370 ---TADLRASNERLKGQIRERRQAEETLRRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRTLSGNTVRFLERGALDT 446
Cdd:COG4192  390 rvfRDQAIEKTQELETEIEERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQ 469

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 447 ASTNLKTINELIDRMGRITASLRSFARRGDDQ-GEASLGKAVDAAFQVLGARLDSLPLTVHRDfANAQLQIDQTRLEQIL 525
Cdd:COG4192  470 LPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPlQPVDLRQVIEQAWELVESRAKPQQITLHIP-DDLMVQGDQVLLEQVL 548

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 526 VNLIGNALDAMQAQavPQLWLEGQSGDGKYRLLVRDNGHGIdPEARKhLFEPFFTTKpgEQGLGLGLTLSASLAAATGGS 605
Cdd:COG4192  549 VNLLVNALDAVATQ--PQISVDLLSNAENLRVAISDNGNGW-PLVDK-LFTPFTTTK--EVGLGLGLSICRSIMQQFGGD 622

                        330
                 ....*....|....*...
gi 504530029 606 LAVEHPANGGTAFVLNLP 623
Cdd:COG4192  623 LYLASTLERGAMVILEFN 640
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 314-628 1.64e-45

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 167.06  E-value: 1.64e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 314 RRAAINQGILVAVAFGLVAFlliawNERRKVIATRLAAREALQEANSQLERRIAERTADLRASNERLKGQIRERRQAEET 393
Cdd:COG5000   87 ERRRYLETILENLPAGVIVL-----DADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERGWQEEIE 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 394 LRRAQD-----------------------ELVQAGKLAAIGQMSTSIAHELNQPLAALRTLSGNTVRFLERGALDTAST- 449
Cdd:COG5000  162 LTRDGRrtllvrasplrddgyvivfdditELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDl 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 450 --NLKTINELIDRMGRITASLRSFARRGDDQ-GEASLGKAVDAAFQVLGARLDSLPLTVHRDFANAQLQI--DQTRLEQI 524
Cdd:COG5000  242 erALDTIIRQVDRLKRIVDEFLDFARLPEPQlEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVlaDRDQLEQV 321

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 525 LVNLIGNALDAMQAQavPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPgeQGLGLGLTLSASLAAATGG 604
Cdd:COG5000  322 LINLLKNAIEAIEEG--GEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP--KGTGLGLAIVKKIVEEHGG 397

                        330       340
                 ....*....|....*....|....
gi 504530029 605 SLAVEHPANGGTAFVLNLPLVGAQ 628
Cdd:COG5000  398 TIELESRPGGGTTFTIRLPLAEEA 421
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
350-631 9.70e-43

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 157.70  E-value: 9.70e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 350 AAREALQEANSQLERRIA-------ERTADLRAS----NERLKGQIRERRQAEEtLRRAQDELVQAGKLAAIGQMSTSIA 418
Cdd:COG3852   65 LLERALAEGQPVTEREVTlrrkdgeERPVDVSVSplrdAEGEGGVLLVLRDITE-RKRLERELRRAEKLAAVGELAAGLA 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 419 HELNQPLAALRtlsGNTVRFLERGALDTASTNLKTINELIDRMGRITASLRSFARRGDDQGEA-SLGKAVDAAFQVLGAR 497
Cdd:COG3852  144 HEIRNPLTGIR---GAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPvNLHEVLERVLELLRAE 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 498 LDSlPLTVHRDFANA--QLQIDQTRLEQILVNLIGNALDAMQAQ--------AVPQLWLEGQSGDGKYRLLVRDNGHGID 567
Cdd:COG3852  221 APK-NIRIVRDYDPSlpEVLGDPDQLIQVLLNLVRNAAEAMPEGgtitirtrVERQVTLGGLRPRLYVRIEVIDNGPGIP 299

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504530029 568 PEARKHLFEPFFTTKpgEQGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPLVGAQRAE 631
Cdd:COG3852  300 EEILDRIFEPFFTTK--EKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
306-624 2.08e-39

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 147.36  E-value: 2.08e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 306 LLTPLNDLRRAAINQGILVAVAFGLVAFLLIAWNERRKVIATRLAAREALQEANSQLERRIAERTADLRASNERLKGQIR 385
Cdd:COG0642   15 LLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 386 ERRQAEETLRRAQdelvqagklAAIGQMSTSIAHELNQPLAALRTLsgntVRFLERGALDTASTNLKTINELIDRMGRIT 465
Cdd:COG0642   95 LLLALLLLLEEAN---------EAKSRFLANVSHELRTPLTAIRGY----LELLLEELDEEQREYLETILRSADRLLRLI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 466 ASLRSFARRGDDQGEA-----SLGKAVDAAFQVLGARLDSLPLTVHRDFAN--AQLQIDQTRLEQILVNLIGNALDAMQA 538
Cdd:COG0642  162 NDLLDLSRLEAGKLELepepvDLAELLEEVVELFRPLAEEKGIELELDLPDdlPTVRGDPDRLRQVLLNLLSNAIKYTPE 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 539 QAvpQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPG--EQGLGLGLTLSASLAAATGGSLAVEHPANGGT 616
Cdd:COG0642  242 GG--TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSrrGGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319


                 ....*...
gi 504530029 617 AFVLNLPL 624
Cdd:COG0642  320 TFTVTLPL 327
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
383-624 3.15e-35

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 133.11  E-value: 3.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 383 QIRERRQAEETLRRAQDELVqagklaaigqmsTSIAHELNQPLAALRTLSGNtvrFLERGALDTASTN--LKTINELIDR 460
Cdd:COG2205    1 ELEEALEELEELERLKSEFL------------ANVSHELRTPLTSILGAAEL---LLDEEDLSPEERRelLEIIRESAER 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 461 MGRITASLRSFARRGDDQ-----GEASLGKAVDAAFQVLGARLDS--LPLTVHRDFANAQLQIDQTRLEQILVNLIGNAL 533
Cdd:COG2205   66 LLRLIEDLLDLSRLESGKlslelEPVDLAELLEEAVEELRPLAEEkgIRLELDLPPELPLVYADPELLEQVLANLLDNAI 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 534 DAMQAQavPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTK--PGEQGLGLGLTLSASLAAATGGSLAVEHP 611
Cdd:COG2205  146 KYSPPG--GTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDnsRGEGGTGLGLAIVKRIVEAHGGTIWVESE 223

                        250
                 ....*....|...
gi 504530029 612 ANGGTAFVLNLPL 624
Cdd:COG2205  224 PGGGTTFTVTLPL 236
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 396-625 1.19e-32

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 129.14  E-value: 1.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 396 RAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRTLsgntVRFLERGALDTASTN-LKTINELIDRMGRITASLRSFARR 474
Cdd:COG5807  133 EAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGF----LQLLQESREDSEREEyFNIIISEIDRINTIITELLVLSKP 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 475 GD-DQGEASLGKAVDAAFQVLGARLDSLPLTVHRDFAN--AQLQIDQTRLEQILVNLIGNALDAMQAQavPQLWLEGQSG 551
Cdd:COG5807  209 KKfNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLADdePVINGDKNQLKQVFINLIKNAIEAMETG--GNITIKTYVE 286

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504530029 552 DGKYRLLVRDNGHGIDPEARKHLFEPFFTTKpgEQGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPLV 625
Cdd:COG5807  287 GDFVVISVKDEGIGIPEEVLEKIGEPFFTTK--EEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPLY 358
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
287-625 8.63e-31

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 124.66  E-value: 8.63e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 287 AVSYLAQTRPLNDTPWNFTLLTPLNDLRRAAINQGILVAVAFGLVAFLLIAWNERRKVIATRLAAREALQEANSQLERRI 366
Cdd:COG5002   58 LLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLR 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 367 AERTADLRASNERLKGQIRERRQAEetlrRAQDELVQagklaaigqmstSIAHELNQPLAALRTLsgntVRFLERGALDT 446
Cdd:COG5002  138 LSALLLGLLLLAAVERDITELERLE----QMRREFVA------------NVSHELRTPLTSIRGY----LELLLDGAADD 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 447 ASTN---LKTINELIDRMGRITASLRSFAR-----RGDDQGEASLGKAVDAAFQVLGARLDSLPLTVHRDFANAQLQI-- 516
Cdd:COG5002  198 PEERreyLEIILEEAERLSRLVNDLLDLSRlesgeLKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVlg 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALDAMQAQAvpQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPG----EQGLGLGL 592
Cdd:COG5002  278 DPDRLEQVLTNLLDNAIKYTPEGG--TITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSrsreTGGTGLGL 355

                        330       340       350
                 ....*....|....*....|....*....|...
gi 504530029 593 TLSASLAAATGGSLAVEHPANGGTAFVLNLPLV 625
Cdd:COG5002  356 AIVKHIVEAHGGRIWVESEPGKGTTFTITLPLA 388
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 384-625 1.47e-30

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 125.61  E-value: 1.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 384 IRERRQAEETLRRAQdelvqagKLAAIGQMSTSIAHELNQPLAALRtlsGntvrFLE--RGALDTASTNLKTINELIDRM 461
Cdd:COG5805  268 ITEKKEAEELMARSE-------KLSIAGQLAAGIAHEIRNPLTSIK---G----FLQllQPGIEDKEEYFDIMLSELDRI 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 462 GRITASLRSFARRGDDQGEA-SLGKAVDAAFQVLG--ARLDSLPLTVHRDFANAQLQIDQTRLEQILVNLIGNALDAMqa 538
Cdd:COG5805  334 ESIISEFLALAKPQAVNKEKeNINELIQDVVTLLEteAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAM-- 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 539 qavPQ---LWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKpgEQGLGLGLTLSASLAAATGGSLAVEHPANGG 615
Cdd:COG5805  412 ---PNggtITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTK--EKGTGLGLMVSYKIIENHNGTIDIDSKVGKG 486

                        250
                 ....*....|
gi 504530029 616 TAFVLNLPLV 625
Cdd:COG5805  487 TTFTITLPLS 496
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
395-624 9.46e-30

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 124.31  E-value: 9.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 395 RRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRTLsgntVRFLERGALDTASTN-LKTINELIDRMGRITASLRSFAR 473
Cdd:PRK11360 375 KRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGY----VQIWRQQTSDPPSQEyLSVVLREVDRLNKVIDQLLEFSR 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 474 RGDDQGEA-SLGKAVDAAFQVLGARLDSLPLTVHRDFANA--QLQIDQTRLEQILVNLIGNALDAMQAQAVPQLWLEgQS 550
Cdd:PRK11360 451 PRESQWQPvSLNALVEEVLQLFQTAGVQARVDFETELDNElpPIWADPELLKQVLLNILINAVQAISARGKIRIRTW-QY 529

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504530029 551 GDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPgeQGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:PRK11360 530 SDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA--KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 107-623 1.21e-27

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 117.19  E-value: 1.21e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 107 YLEGLNRRSRSRAIYVMDTTGRVLATSNWRDADSYQGEDLSFRAYFQNAVRGQPGRFYGIGSTNGEPGYYLAHGLEEHGK 186
Cdd:COG4251    7 LLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 187 IIGVAVVKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKAVRPLSDDTKDRLAHSLQYYWATLNELQPLARERL 266
Cdd:COG4251   87 LELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLAL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 267 NEGTEKLTFPANTEVVNDQHAVSYLAQTRPLNDTPWNFTLLTPLNDLRRAAINQGILVAVAFGLVAFLLIAWNERRKVIA 346
Cdd:COG4251  167 ILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLL 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 347 TRLAAREALQE--ANSQLERRIAERTADLRASNERLKgqirerrqaeetlrraqdelvqagklaaigQMSTSIAHELNQP 424
Cdd:COG4251  247 LLILVLELLELrlELEELEEELEERTAELERSNEELE------------------------------QFAYVASHDLREP 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 425 LAALRTLSgntvRFLER---GALD-TASTNLKTINELIDRMGRITASLRSFAR---RGDDQGEASLGKAVDAAFQVLGAR 497
Cdd:COG4251  297 LRKISGFS----QLLEEdygDKLDeEGREYLERIRDAAERMQALIDDLLAYSRvgrQELEFEPVDLNELLEEVLEDLEPR 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 498 LDSLPLTVHRDfANAQLQIDQTRLEQILVNLIGNALDAMQAQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEP 577
Cdd:COG4251  373 IEERGAEIEVG-PLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEI 451

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 504530029 578 FFTTKPGEQ--GLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:COG4251  452 FQRLHSRDEyeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
PRK15347 PRK15347
two component system sensor kinase;
354-624 2.81e-26

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 114.74  E-value: 2.81e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 354 ALQEANSQLERRIAERTADLRasnerlkgqiRERRQAEETLRRAQDELvqagklaaigqmsTSIAHELNQPL----AALR 429
Cdd:PRK15347 365 TLNEQYDTLENKVAERTQALA----------EAKQRAEQANKRKSEHL-------------TTISHEIRTPLngvlGALE 421

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 430 TLSGNTVRFLERGALDTA--STN--LKTINELIDrmgritaslrsFARRGDDQGEASLGKA-----VDAAFQVLGARLDS 500
Cdd:PRK15347 422 LLQNTPLTAEQMDLADTArqCTLslLAIINNLLD-----------FSRIESGQMTLSLEETallplLDQAMLTIQGPAQS 490

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 501 LPLTVhRDFANAQ----LQIDQTRLEQILVNLIGNALDAMQAQavpQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFE 576
Cdd:PRK15347 491 KSLTL-RTFVGAHvplyLHLDSLRLRQILVNLLGNAVKFTETG---GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFT 566

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 504530029 577 PFFTTKPGEQGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:PRK15347 567 PFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 516-624 6.99e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 102.34  E-value: 6.99e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029   516 IDQTRLEQILVNLIGNALDAMQAQavPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQ---GLGLGL 592
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEG--GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkigGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 504530029   593 TLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:smart00387  79 SIVKKLVELHGGEISVESEPGGGTTFTITLPL 110
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-622 7.02e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 102.15  E-value: 7.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDAMQAQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGLGLGLTLSASLAA 600
Cdd:cd16976    1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVE 80

                         90       100
                 ....*....|....*....|..
gi 504530029 601 ATGGSLAVEHPANGGTAFVLNL 622
Cdd:cd16976   81 EHGGRLSVANEEGAGARFTFDL 102
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 383-625 2.64e-25

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 109.45  E-value: 2.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 383 QIRERRQAEETLRRAQDElvqagKLAAIGQMSTSIAHELNQPLAALrtlSGnTVRFLERGALDTASTN-LKTINELIDRM 461
Cdd:COG5808  219 LLKRKTLLERVIQEINTQ-----KLELIGTFAASTAHEIRNPLTSI---KG-FIQLLQEKYPELEDQKyFDIIQEEIQRI 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 462 GRITASLRSFARRGDDQGE-ASLGKAVDAAFQVLGARLDSLPLTVHRDFANAQLQI--DQTRLEQILVNLIGNALDAMQA 538
Cdd:COG5808  290 NQIVSEFLVLGKPTAKKLElDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIkcDKDRIKQVLLNLIKNAIEAMKE 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 539 QAVPQLWLEGQsgDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKpgEQGLGLGLTLSASLAAATGGSLAVEHPANGGTAF 618
Cdd:COG5808  370 GGKLTISIEND--DEKAVIEVIDNGEGIPEDIIDEIFEPFVTTK--EGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTF 445


                 ....*..
gi 504530029 619 VLNLPLV 625
Cdd:COG5808  446 TIRLPLK 452
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 333-632 1.01e-24

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 108.14  E-value: 1.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 333 FLLIAWNERRKVIAtrLAAREALQEANSQLERRIA---ERTADLRAS------NERLKGQ------IRERRQAEETLRRA 397
Cdd:COG5809  187 LELIHSDDQENVAA--FISQLLKDGGIAQGEVRFWtkdGRWRLLEASgapikkNGEVDGIviifrdITERKKLEELLRKS 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 398 QdelvqagKLAAIGQMSTSIAHELNQPLAALRTLsgntVRFLERGALDTASTNLKTINELIDRMGRITASLRSFARRGDD 477
Cdd:COG5809  265 E-------KLSVVGELAAGIAHEIRNPLTSLKGF----IQLLKDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAI 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 478 QGE-ASLGKAVDAAFQVLGARLDSLPLTVHRDFAN--AQLQIDQTRLEQILVNLIGNALDAM--------QAQAVPqlwl 546
Cdd:COG5809  334 KYEpKDLNTLIEEVIPLLQPQALLKNVQIELELEDdiPDILGDENQLKQVFINLLKNAIEAMpeggnitiETKAED---- 409

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 547 egqsgDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKpgEQGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPLVG 626
Cdd:COG5809  410 -----DDKVVISVTDEGCGIPEERLKKLGEPFYTTK--EKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKL 482


                 ....*.
gi 504530029 627 AQRAES 632
Cdd:COG5809  483 SEQVSM 488
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-624 1.52e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 98.26  E-value: 1.52e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDAMQAQAvpQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGLGLGLTLSASLAA 600
Cdd:cd16943    4 LNQVLLNLLVNAAQAMEGRG--RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQ 81

                         90       100
                 ....*....|....*....|....
gi 504530029 601 ATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:cd16943   82 KHGGTIRVASVPGGGTRFTIILPI 105
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 521-622 2.49e-24

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 97.67  E-value: 2.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDAMQAQavPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKP--GEQGLGLGLTLSASL 598
Cdd:cd00075    1 LEQVLSNLLDNALKYSPPG--GTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKsrEGGGTGLGLAIVRRI 78

                         90       100
                 ....*....|....*....|....
gi 504530029 599 AAATGGSLAVEHPANGGTAFVLNL 622
Cdd:cd00075   79 VEAHGGRITVESEPGGGTTFTVTL 102
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-623 7.28e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 96.31  E-value: 7.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDAMQAQAVP--QLWLE-GQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPgeQGLGLGLTLSAS 597
Cdd:cd16920    1 IQQVLINLVRNGIEAMSEGGCErrELTIRtSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKS--EGLGMGLSICRS 78

                         90       100
                 ....*....|....*....|....*.
gi 504530029 598 LAAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16920   79 IIEAHGGRLSVESPAGGGATFQFTLP 104
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 517-624 2.34e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 95.13  E-value: 2.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  517 DQTRLEQILVNLIGNALDAMQAQAVPQLWLEGqsgDGKYRLLVRDNGHGIDPEARKHLFEPFFTT-KPGEQGLGLGLTLS 595
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE---GGELTLTVEDNGIGIPPEDLPRIFEPFSTAdKRGGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*....
gi 504530029  596 ASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTLPL 107
PRK13557 PRK13557
histidine kinase; Provisional
 384-628 4.75e-21

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 97.05  E-value: 4.75e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 384 IRERRQAEETLRRAQdelvqagKLAAIGQMSTSIAHELNQPLAA----LRTLSGNtvrfLERGALDTA--STNLKTINEL 457
Cdd:PRK13557 144 VSRRRDAEDALRQAQ-------KMEALGQLTGGIAHDFNNLLQVmsgyLDVIQAA----LSHPDADRGrmARSVENIRAA 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 458 IDRMGRITASLRSFARRGDDQGEA-SLGKAVDAAFQVLGARLD---SLPLTVHRDFANAQlqIDQTRLEQILVNLIGNAL 533
Cdd:PRK13557 213 AERAATLTQQLLAFARKQRLEGRVlNLNGLVSGMGELAERTLGdavTIETDLAPDLWNCR--IDPTQAEVALLNVLINAR 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 534 DAMQAQ------------AVPQLWLEGQSGDGKY-RLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGLGLGLTLSASLAA 600
Cdd:PRK13557 291 DAMPEGgrvtirtrnveiEDEDLAMYHGLPPGRYvSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGFAK 370

                        250       260
                 ....*....|....*....|....*...
gi 504530029 601 ATGGSLAVEHPANGGTAFVLNLPLVGAQ 628
Cdd:PRK13557 371 QSGGAVRIYSEVGEGTTVRLYFPASDQA 398
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
387-629 5.24e-21

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 96.39  E-value: 5.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 387 RRQAEETLRRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRtlsGNTVRFLERGALDTASTNL-KTINELIDRMGRIT 465
Cdd:PRK10364 214 YRRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIK---GLAKYFAERAPAGGEAHQLaQVMAKEADRLNRVV 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 466 ASLRSFARRGDDQGEAS-LGKAVDAAFQVLGARLDSLPLTVhRDFANAQL---QIDQTRLEQILVNLIGNALDAMQAQAV 541
Cdd:PRK10364 291 SELLELVKPTHLALQAVdLNDLINHSLQLVSQDANSREIQL-RFTANDTLpeiQADPDRLTQVLLNLYLNAIQAIGQHGV 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 542 pqLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKpgEQGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLN 621
Cdd:PRK10364 370 --ISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLW 445


                 ....*...
gi 504530029 622 LPLVGAQR 629
Cdd:PRK10364 446 LPVNITRR 453
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 352-627 3.76e-20

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 92.99  E-value: 3.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 352 REALQEANSQLERRIAERTADLRASNERLKGQIRerrQAEETLRRAQDELVQAGKLAAIGQMSTSI---AHEL-NQplaa 427
Cdd:COG3290  131 AEVLETGERDEEILLNGRVLVVNRVPIRDDGRVV---GAVATFRDRTELERLEEELEGVKELAEALraqRHDFrNH---- 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 428 LRTLSGntvrFLERGALDTAstnLKTINELIDRMGRITASLRSfaRRGDDqgeaslgkAVDAAFQVLGARLDSL--PLTV 505
Cdd:COG3290  204 LHTISG----LLQLGEYDEA---LEYIDEISEELQELIDSLLS--RIGNP--------VLAALLLGKAARARERgiDLTI 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 506 HRDFANAQLQIDQTRLEQILVNLIGNALDAMQAQA--VPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKP 583
Cdd:COG3290  267 DIDSDLPDLPLSDTDLVTILGNLLDNAIEAVEKLPeeERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKL 346

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 504530029 584 GEqGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPLVGA 627
Cdd:COG3290  347 GE-GRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
386-624 3.96e-20

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 95.13  E-value: 3.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 386 ERRQAEETLRRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRtlsGNTVrfLERGALDTASTNLKTINELI---DRMG 462
Cdd:PRK13837 426 ERRRLETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAIL---GYAE--MALNKLARHSRAARYIDEIIsagARAR 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 463 RITASLRSFARRGD-DQGEASLGKAVDAAFQVLGArldSLPLTVHRDFANAQLQI----DQTRLEQILVNLIGNALDAMQ 537
Cdd:PRK13837 501 LIIDQILAFGRKGErNTKPFDLSELVTEIAPLLRV---SLPPGVELDFDQDQEPAvvegNPAELQQVLMNLCSNAAQAMD 577

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 538 AQAV------------PQLWLEGQSGDGKY-RLLVRDNGHGIDPEARKHLFEPFFTTKPGeqGLGLGLTLSASLAAATGG 604
Cdd:PRK13837 578 GAGRvdislsraklraPKVLSHGVLPPGRYvLLRVSDTGAGIDEAVLPHIFEPFFTTRAG--GTGLGLATVHGIVSAHAG 655

                        250       260
                 ....*....|....*....|
gi 504530029 605 SLAVEHPANGGTAFVLNLPL 624
Cdd:PRK13837 656 YIDVQSTVGRGTRFDVYLPP 675
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 521-623 1.03e-16

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 76.26  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDAMQ------------------AQAVPQLwlegqsGDGKYRLL-VRDNGHGIDPEARKHLFEPFFTT 581
Cdd:cd16919    1 LELAILNLAVNARDAMPeggrltietsnqrvdadyALNYRDL------IPGNYVCLeVSDTGSGMPAEVLRRAFEPFFTT 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 504530029 582 KPGEQGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16919   75 KEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
PRK10604 PRK10604
sensor protein RstB; Provisional
 407-624 1.67e-16

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 82.34  E-value: 1.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 407 LAAIGQMSTSIAHELNQPLAALRtlsgntVRFLERGALDTAstNLKTINELIDRMGRITASLRSFARRgdDQGEASLGKA 486
Cdd:PRK10604 209 IASKKQLIDGIAHELRTPLVRLR------YRLEMSDNLSAA--ESQALNRDIGQLEALIEELLTYARL--DRPQNELHLS 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 487 VDAAFQVLGARLDSL-----PLTVHRDFAN-AQLQIDQTRL-EQILVNLIGNALDAMQAQAVPQLWLEGQsgdgKYRLLV 559
Cdd:PRK10604 279 EPDLPAWLSTHLADIqavtpEKTVRLDTPHqGDYGALDMRLmERVLDNLLNNALRYAHSRVRVSLLLDGN----QACLIV 354

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504530029 560 RDNGHGIDPEARKHLFEPFFTTKPGEQ----GLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:PRK10604 355 EDDGPGIPPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 354-624 2.62e-16

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 83.03  E-value: 2.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 354 ALQEANSQLERRIAERTADLRAsnerlkgQIRERRQAeetlrRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRTLSG 433
Cdd:PRK11466 404 ALNRHREQLAAQVKARTAELQE-------LVIEHRQA-----RAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 434 NTVRFLERGAL----DTASTNLKTINELIDrMGRITASLRSFARRGDDQGEASLgkaVDAAFQVLGARLDSLPLTVHRDF 509
Cdd:PRK11466 472 NPALNAQRDDLraitDSGESLLTILNDILD-YSAIEAGGKNVSVSDEPFEPRPL---LESTLQLMSGRVKGRPIRLATDI 547

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 510 AN---AQLQIDQTRLEQILVNLIGNALDAMQAQAVPqlwLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQ 586
Cdd:PRK11466 548 ADdlpTALMGDPRRIRQVITNLLSNALRFTDEGSIV---LRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRG 624

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 504530029 587 GLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:PRK11466 625 GTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 51-302 4.46e-16

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 78.15  E-value: 4.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029   51 IRTLSDNGERQLELHARTVESELSKYTYLPSLLELESSVSQLLADPNQETRktvNDYLEGLNRRSRSRAIYVMDTTGRVL 130
Cdd:pfam02743   4 KEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEEL---AKLESLLRSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  131 ATSNwrDADSYQGEDLSFRAYFQNAVRGQPGRFYGIGS-----TNGEPGYYLAHGLE-EHGKIIGVAVVKVRLEALEERW 204
Cdd:pfam02743  81 ASSD--ESPSYPGLDVSERPWYKEALKGGGGIIWVFSSpypssESGEPVLTIARPIYdDDGEVIGVLVADLDLDTLQELL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  205 QRARL----EAFVSDENGIIILSSDParrlkavRPLSDDTKDRLAHSLQYYWatlnelqplarerlnegtekLTFPANTE 280
Cdd:pfam02743 159 SQIKLgeggYVFIVDSDGRILAHPLG-------KNLRSLLAPFLGKSLADAL--------------------PGSGITEI 211

                         250       260
                  ....*....|....*....|..
gi 504530029  281 VVNDQHaVSYLAQTRPLNDTPW 302
Cdd:pfam02743 212 AVDLDG-EDYLVAYAPIPGTGW 232
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 524-623 8.25e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 73.48  E-value: 8.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 524 ILVNLIGNALDAMQAQAVPQLWLE---GQSGDgKYRLLVRDNGHGIDPEARKHLFEPFFTTKpGEQGLGLGLTLSASLAA 600
Cdd:cd16915    4 IVGNLIDNALDALAATGAPNKQVEvflRDEGD-DLVIEVRDTGPGIAPELRDKVFERGVSTK-GQGERGIGLALVRQSVE 81

                         90       100
                 ....*....|....*....|...
gi 504530029 601 ATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16915   82 RLGGSITVESEPGGGTTFSIRIP 104
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 521-624 5.63e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 71.37  E-value: 5.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNAL---DamQAQAVPQLWLEGQSGDGKY-RLLVRDNGHGIDPEARKHLFEPF------FTTKPGeqGLGL 590
Cdd:cd16922    1 LRQILLNLLGNAIkftE--EGEVTLRVSLEEEEEDGVQlRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYG--GTGL 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 504530029 591 GLTLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:cd16922   77 GLAISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 517-623 3.46e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 69.03  E-value: 3.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNAL---DA-----MQAQAVPQLWlegqsgdgkyRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQ-- 586
Cdd:cd16946    1 DRDRLQQLFVNLLENSLrytDTggklrIRAAQTPQEV----------RLDVEDSAPGVSDDQLARLFERFYRVESSRNra 70

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 504530029 587 --GLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16946   71 sgGSGLGLAICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 382-626 1.32e-13

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 73.34  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 382 GQIRERRQAEETLRRAQDelvqaGKlAAIGQMSTSIAHELNQPLAALR--------TLSGNTVRFLergaLDTASTNLKT 453
Cdd:PRK11100 234 SELRELAQALESMRVKLE-----GK-AYVEQYVQTLTHELKSPLAAIRgaaellqeDPPPEDRARF----TGNILTQSAR 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 454 INELIDRMGRItASLRSfaRRGDDQGE----ASLGKAVDAAFQvlgARLDSLPLTVHRDFANAQLQIDQTRLEQILVNLI 529
Cdd:PRK11100 304 LQQLIDRLLEL-ARLEQ--RQELEVLEpvalAALLEELVEARE---AQAAAKGITLRLRPDDARVLGDPFLLRQALGNLL 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 530 GNALDAMQAQAVpqLWLEGQSGDGKYRLLVRDNGHGIdPE-ARKHLFEPFFTT-KP--GEQGLGLGLTLSASLAAATGGS 605
Cdd:PRK11100 378 DNAIDFSPEGGT--ITLSAEVDGEQVALSVEDQGPGI-PDyALPRIFERFYSLpRPanGRKSTGLGLAFVREVARLHGGE 454

                        250       260
                 ....*....|....*....|.
gi 504530029 606 LAVEHPANGGTAFVLNLPLVG 626
Cdd:PRK11100 455 VTLRNRPEGGVLATLTLPRHF 475
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-623 1.31e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 64.27  E-value: 1.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDAMQAQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQ--GLGLGLTLSASL 598
Cdd:cd16921    1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEyeGTGVGLAIVRKI 80

                         90       100
                 ....*....|....*....|....*
gi 504530029 599 AAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16921   81 IERHGGRIWLESEPGEGTTFYFTLP 105
glnL PRK11073
nitrogen regulation protein NR(II);
395-624 2.29e-12

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 68.57  E-value: 2.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 395 RRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRtlsgNTVRFLERGALDTASTNL-KTINELIDRMGRITASLRSFAR 473
Cdd:PRK11073 115 RRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLR----GAAQLLSKALPDPALTEYtKVIIEQADRLRNLVDRLLGPQR 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 474 RGDDQGEaSLGKAVDAAFQVLgaRLDSLP-LTVHRDFANA--QLQIDQTRLEQILVNLIGNALDAMQAQ---------AV 541
Cdd:PRK11073 191 PGTHVTE-SIHKVAERVVQLV--SLELPDnVRLIRDYDPSlpELAHDPDQIEQVLLNIVRNALQALGPEggtitlrtrTA 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 542 PQLWLEGQsgdgKYRLLVR----DNGHGIDPEARKHLFEPFFTTKPGeqGLGLGLTLSASLAAATGGSLAVEH-PanGGT 616
Cdd:PRK11073 268 FQLTLHGE----RYRLAARidieDNGPGIPPHLQDTLFYPMVSGREG--GTGLGLSIARNLIDQHSGKIEFTSwP--GHT 339


                 ....*...
gi 504530029 617 AFVLNLPL 624
Cdd:PRK11073 340 EFSVYLPI 347
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-624 4.26e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 62.83  E-value: 4.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDAMQAQAVPQLWLEGqsgdGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQ----GLGLGLTLSA 596
Cdd:cd16939    1 MARALDNLLRNALRYAHRTVRIALLVSG----GRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDratgGFGLGLAIVH 76

                         90       100
                 ....*....|....*....|....*...
gi 504530029 597 SLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:cd16939   77 RVALWHGGHVECDDSELGGACFRLTWPR 104
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 517-623 2.76e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 60.63  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALDAMQAQA--VPQLWLEGQSG-DGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPgeQGLGLGLT 593
Cdd:cd16944    1 DTTQISQVLTNILKNAAEAIEGRPsdVGEVRIRVEADqDGRIVLIVCDNGKGFPREMRHRATEPYVTTRP--KGTGLGLA 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 504530029 594 LSASLAAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16944   79 IVKKIMEEHGGRISLSNREAGGACIRIILP 108
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-623 4.68e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 60.11  E-value: 4.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDA---------MQAQAVPQLWLEGQsgdgKYRLLVR----DNGHGIDPEARKHLFEPFFTTKpgEQG 587
Cdd:cd16918    1 LIQVFLNLVRNAAQAlagsggeiiLRTRTQRQVTLGHP----RHRLALRvsviDNGPGIPPDLQDTIFYPMVSGR--ENG 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 504530029 588 LGLGLTLSASLAAATGGSLAVE-HPanGGTAFVLNLP 623
Cdd:cd16918   75 TGLGLAIAQNIVSQHGGVIECDsQP--GHTVFSVSLP 109
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
417-625 5.71e-11

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 65.04  E-value: 5.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 417 IAHELNQPLAALR-TLSG--NTVRFLERGALDTASTNLKTINELIDRMGRITASLR-SFARRGDDQGEASLGKAVDAAFQ 492
Cdd:PRK10549 247 ISHELRTPLAVLRgELEAiqDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEgALAYRKTPVDLVPLLEVAGGAFR 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 493 vlgARLDSLPLTVHRDFA-NAQLQIDQTRLEQILVNLIGNALDAMQAQAvpQLWLEGQSGDGKYRLLVRDNGHGIDPEAR 571
Cdd:PRK10549 327 ---ERFASRGLTLQLSLPdSATVFGDPDRLMQLFNNLLENSLRYTDSGG--SLHISAEQRDKTLRLTFADSAPGVSDEQL 401

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 504530029 572 KHLFEPFFTTKPGEQ----GLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPLV 625
Cdd:PRK10549 402 QKLFERFYRTEGSRNrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLE 459
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-623 1.11e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 59.12  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDAMQAQAVPQLWLEGQSGDgKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGE----QGLGLGLTLSA 596
Cdd:cd16953    1 LGQVLRNLIGNAISFSPPDTGRITVSAMPTGK-MVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgQHSGLGLSISR 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 504530029 597 SLAAATGGSLAVE-HPANG---GTAFVLNLP 623
Cdd:cd16953   80 QIIEAHGGISVAEnHNQPGqviGARFTVQLP 110
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-623 1.33e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 58.61  E-value: 1.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDamqaqaVPQLWLEGQS-GDGKY-RLLVRDNGHGIDPEARKHLFEPFF--TTKPGEQGLGLGLTLSA 596
Cdd:cd16950    1 LKRVLSNLVDNALR------YGGGWVEVSSdGEGNRtRIQVLDNGPGIAPEEVDELFQPFYrgDNARGTSGTGLGLAIVQ 74

                         90       100
                 ....*....|....*....|....*..
gi 504530029 597 SLAAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16950   75 RISDAHGGSLTLANRAGGGLCARIELP 101
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 510-616 4.28e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 57.42  E-value: 4.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 510 ANAQLQIDQTRLEQILVNLIGNALDAMQAQAVPQLWLEGQSGDgkyRLLVRDNGHGIDPEARKHLFEPFFTTKP-GEQGL 588
Cdd:cd16940    3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGA---VIRVEDNGPGIDEEELEALFERFYRSDGqNYGGS 79

                         90       100
                 ....*....|....*....|....*...
gi 504530029 589 GLGLTLSASLAAATGGSLAVEHPANGGT 616
Cdd:cd16940   80 GLGLSIVKRIVELHGGQIFLGNAQGGGL 107
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 524-623 3.13e-09

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 59.93  E-value: 3.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 524 ILVNLIGNALDAMQAQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGLGLGLTLSAslAAATG 603
Cdd:PRK11086 437 ILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQS--VENLG 514

                         90       100
                 ....*....|....*....|
gi 504530029 604 GSLAVEHPANGGTAFVLNLP 623
Cdd:PRK11086 515 GSIAVESEPGVGTQFFVQIP 534
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 518-624 5.19e-09

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 59.15  E-value: 5.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  518 QTRLEQILVNLIGNALDAMQAQAVP--QLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPG-EQGLGLGLTL 594
Cdd:TIGR02938 385 ELQLRSLFKALVDNAIEAMNIKGWKrrELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGsRKHIGMGLSV 464

                          90       100       110
                  ....*....|....*....|....*....|
gi 504530029  595 SASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:TIGR02938 465 AQEIVADHGGIIDLDDDYSEGCRIIVEFRV 494
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 515-622 1.91e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 52.90  E-value: 1.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 515 QIDQTRLEQILVNLIGNALDamqaqavpqlwlegQSGDGKYRLL------------VRDNGHGIDPEARKHLFEPFFTTK 582
Cdd:cd16947   15 NANTEALQRILKNLISNAIK--------------YGSDGKFLGMtlredekhvyidIWDKGKGISETEKDHVFERLYTLE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 504530029 583 PGE----QGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNL 622
Cdd:cd16947   81 DSRnsakQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
PDC1_DGC_like cd12914
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ...
 93-197 1.94e-08

first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350339  Cd Length: 123  Bit Score: 52.77  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  93 LADPNQETRKTVNDYLEGLNRRSRS-RAIYVMDTTGRVLATSNwrdADSYQGEDLSFRAYFQNAVRGQPGRFYG---IGS 168
Cdd:cd12914   17 ARGAASADPAALQALLRRLLARLPEvRSIFVVDADGRVVASSG---PGPAPGLDVSDRDYFQAARAGGGGLFISepvISR 93

                         90       100       110
                 ....*....|....*....|....*....|
gi 504530029 169 TNGEPGYYLAHGLE-EHGKIIGVAVVKVRL 197
Cdd:cd12914   94 VTGKPVIPLSRPIRdADGRFAGVVVASIDL 123
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
517-628 2.97e-08

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 56.91  E-value: 2.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALDAMQAQAVPqlwLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGE----QGLGLGL 592
Cdd:PRK10841 559 DPMRLQQVISNLLSNAIKFTDTGCIV---LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVqrnfQGTGLGL 635

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 504530029 593 TLSASLAAATGGSLAVEHPANGGTAFVLNLPLVGAQ 628
Cdd:PRK10841 636 AICEKLINMMDGDISVDSEPGMGSQFTIRIPLYGAQ 671
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 517-623 5.70e-08

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 51.34  E-value: 5.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALDAMQAQAVPQLWLEgQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQ----GLGLGL 592
Cdd:cd16925    1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILE-KFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTrahgGTGLGL 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 504530029 593 TLSASLAAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16925   80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 517-618 8.20e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 50.54  E-value: 8.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALDAMQAQAVPQLWLEgqSGDGKYRLLVRDNGHGIDPEARKHLFEPFFT-TKP--GEQGLGLGLT 593
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLE--ADTEGIELLVFDEGSGIPDYALNRVFERFYSlPRPhsGQKSTGLGLA 78

                         90       100
                 ....*....|....*....|....*
gi 504530029 594 LSASLAAATGGSLAVEHPANGGTAF 618
Cdd:cd16945   79 FVQEVAQLHGGRITLRNRPDGVLAF 103
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
384-624 1.88e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 54.36  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  384 IRERRQAEETLRRAQDELVQAgkLAAIGQMSTSIAHELNQPLAA----LRTLSGNTVRFLERG-----ALDTASTNLKTI 454
Cdd:PRK09959  688 ITETRDLIHALEVERNKAINA--TVAKSQFLATMSHEIRTPISSimgfLELLSGSGLSKEQRVeaislAYATGQSLLGLI 765

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  455 NELIDrMGRITASLRSFARRGDDQgeASLGKAVDAAFQVLGARlDSLPLTVHRDFANAQL-QIDQTRLEQILVNLIGNAL 533
Cdd:PRK09959  766 GEILD-VDKIESGNYQLQPQWVDI--PTLVQNTCHSFGAIAAS-KSIALSCSSTFPDHYLvKIDPQAFKQVLSNLLSNAL 841

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  534 DAMQAQAVP--QLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQ--GLGLGLTLSASLAAATGGSLAVE 609
Cdd:PRK09959  842 KFTTEGAVKitTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQqtGSGLGLMICKELIKNMQGDLSLE 921

                         250
                  ....*....|....*
gi 504530029  610 HPANGGTAFVLNLPL 624
Cdd:PRK09959  922 SHPGIGTTFTITIPV 936
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 521-624 2.23e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 49.25  E-value: 2.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 521 LEQILVNLIGNALDamqaQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQ----GLGLGLTLSA 596
Cdd:cd16949    1 LARALENVLRNALR----YSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDresgGTGLGLAIAE 76

                         90       100
                 ....*....|....*....|....*...
gi 504530029 597 SLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:cd16949   77 RAIEQHGGKIKASNRKPGGLRVRIWLPA 104
PRK10490 PRK10490
sensor protein KdpD; Provisional
 454-624 4.88e-07

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 53.12  E-value: 4.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 454 INELIDrMGRITASlrSFARRGDDQgeaSLGKAVDAAFQVLGARLDSLPLTVHRDFANAQLQIDQTRLEQILVNLIGNAL 533
Cdd:PRK10490 718 VNNLLD-MARIQSG--GFNLRKEWL---TLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAV 791

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 534 DAMQAQAvpQLWLEGQSGDGKYRLLVRDNGHGIDPEARKHLFEPFfttKPGEQ-----GLGLGLTLSASLAAATGGSLAV 608
Cdd:PRK10490 792 KYAGAQA--EIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF---ARGNKesaipGVGLGLAICRAIVEVHGGTIWA 866

                        170
                 ....*....|....*.
gi 504530029 609 EHPANGGTAFVLNLPL 624
Cdd:PRK10490 867 ENRPEGGACFRVTLPL 882
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-623 1.77e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 46.90  E-value: 1.77e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504530029 552 DGKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGL---GLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16948   35 EQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQestGMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 384-624 2.00e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 51.09  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 384 IRERRQAEETLRRAQDElvqagKLAAIgqmSTsIAHELNQPLaalrtlsgNTVRFLERGALDTASTN-----LKTI---- 454
Cdd:PRK11091 266 ITERKRYQDALEKASRD-----KTTFI---ST-ISHELRTPL--------NGIVGLSRILLDTELTAeqrkyLKTIhvsa 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 455 -------NELI--DRMGR--------------ITASLRSFARRgddqgeasLGKAVDAAFQVlgARLDSLPltvhrdfan 511
Cdd:PRK11091 329 itlgnifNDIIdmDKMERrklqldnqpidftdFLADLENLSGL--------QAEQKGLRFDL--EPLLPLP--------- 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 512 AQLQIDQTRLEQILVNLIGNALDAMQAQAVpQLWLEGQSGDgKYRLLVRDNGHGIDPEARKHLFEPFFTTKPGEQGL--- 588
Cdd:PRK11091 390 HKVITDGTRLRQILWNLISNAVKFTQQGGV-TVRVRYEEGD-MLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKpat 467

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 504530029 589 --GLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:PRK11091 468 gtGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
385-627 2.70e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 49.23  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 385 RERRQAEETLRRAQDELVQAGKLAAIgqmsTSIAHEL----NQPLAALRTLSGNTVRFLERGAlDTASTNLKTINELIDR 460
Cdd:COG4585   29 ARRAERAAELERELAARAEEAREEER----RRIARELhdgvGQSLSAIKLQLEAARRLLDADP-EAAREELEEIRELARE 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 461 mgrITASLRSFAR--RGDDQGEASLGKAVDAAFQVLGARLDsLPLTVHRDFANAQLQIDQTR-LEQILVNLIGNALDamQ 537
Cdd:COG4585  104 ---ALAELRRLVRglRPPALDDLGLAAALEELAERLLRAAG-IRVELDVDGDPDRLPPEVELaLYRIVQEALTNALK--H 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 538 AQAvPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKhlfepffttkpgeqGLGLGLTLSASLAAATGGSLAVEHPANGGTA 617
Cdd:COG4585  178 AGA-TRVTVTLEVDDGELTLTVRDDGVGFDPEAAP--------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTR 242

                        250
                 ....*....|
gi 504530029 618 FVLNLPLVGA 627
Cdd:COG4585  243 VRATLPLAAA 252
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 517-615 3.44e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 45.92  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALDAMQAQAVPQLWLEGQSGDGKYrlLVRDNGHGIDPEARKHLFEPFFTTKPGEQG---LGLGLT 593
Cdd:cd16975    1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYF--EIWDNGHGFSEQDLKKALELFYRDDTSRRSgghYGMGLY 78

                         90       100
                 ....*....|....*....|..
gi 504530029 594 LSASLAAATGGSLAVEHPANGG 615
Cdd:cd16975   79 IAKNLVEKHGGSLIIENSQKGG 100
envZ PRK09467
osmolarity sensor protein; Provisional
 524-625 4.57e-06

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 49.52  E-value: 4.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 524 ILVNLIGNALDAMQAqavpqlWLEGQSG-DGKY-RLLVRDNGHGIDPEARKHLFEPFFT--TKPGEQGLGLGLTLSASLA 599
Cdd:PRK09467 335 ALANLVVNAARYGNG------WIKVSSGtEGKRaWFQVEDDGPGIPPEQLKHLFQPFTRgdSARGSSGTGLGLAIVKRIV 408

                         90       100
                 ....*....|....*....|....*.
gi 504530029 600 AATGGSLAVEHPANGGTAFVLNLPLV 625
Cdd:PRK09467 409 DQHNGKVELGNSEEGGLSARAWLPLT 434
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 516-625 8.66e-06

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 48.68  E-value: 8.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 516 IDQTRLEQILVNLIGNALDAM----QAQAVPQLWLEGQSGDgkYRLLVRDNGHGIDPEARKHLFEPFFTTK---PGEQGL 588
Cdd:PRK15053 428 LDSTEFAAIVGNLLDNAFEASlrsdEGNKIVELFLSDEGDD--VVIEVADQGCGVPESLRDKIFEQGVSTRadePGEHGI 505

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 504530029 589 GLGLTlsASLAAATGGSLAVEHPANGGTAFVLNLPLV 625
Cdd:PRK15053 506 GLYLI--ASYVTRCGGVITLEDNDPCGTLFSIFIPKV 540
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 108-624 1.43e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 47.98  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 108 LEGLNRRSRSRAIYVMDTTGRVLATSNWRDADSYQGEDLSFRAYFQNAVRGQPGRFYGIGSTNGEPGYYLAHGLEEHGKI 187
Cdd:COG3920    2 LLALLLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 188 IGVAVVKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKAVRPLSDDTKDRLAHSLQYYWATLNELQPLARERLN 267
Cdd:COG3920   82 LALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 268 EGTEKLTFPANTEVVNDQHAVSYLAQTRPLNDTPWNFTLLTPLNDLRRAAINQGILVAVAFGLVAFLLIAWNERRKVIAT 347
Cdd:COG3920  162 LLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEEL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 348 RLAAREALQEANSQLERRIAERTADLRASNERLKGQIRERRQAEETLRRAQDELvqagklaaigqmsTSIAHELN----- 422
Cdd:COG3920  242 ERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEK-------------ELLLRELHhrvkn 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 423 --QPLAALRTLsgnTVRFLERGALDTAstnlktINELIDR---MGRITASLRsfarRGDDQGEASLGKAVDAAFQVLGAR 497
Cdd:COG3920  309 nlQVVSSLLRL---QARRADDPEAREA------LEESQNRiqaLALVHELLY----QSEDWEGVDLRDYLRELLEPLRDS 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 498 LDSLPLTVHRDFANAQLQIDQ-TRLEQILVNLIGNALD-AMQAQAVPQLWLEGQSGDGKYRLLVRDNGHGIDPEARKhlf 575
Cdd:COG3920  376 YGGRGIRIELDGPDVELPADAaVPLGLILNELVTNALKhAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDP--- 452

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 504530029 576 epffttkpgEQGLGLGLTLSASLAAATGGSLAVEHPAngGTAFVLNLPL 624
Cdd:COG3920  453 ---------PARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPL 490
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 407-473 1.44e-05

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 42.97  E-value: 1.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504530029 407 LAAIGQMSTSIAHELNQPLAALRTLSGntvrFLERGALDTAST--NLKTINELIDRMGRITASLRSFAR 473
Cdd:cd00082    1 LQAKGEFLANVSHELRTPLTAIRGALE----LLEEELLDDEEQreYLERIREEAERLLRLINDLLDLSR 65
PDC1_HK_sensor cd18773
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase ...
 81-197 1.50e-05

first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.


Pssm-ID: 350341 [Multi-domain]  Cd Length: 125  Bit Score: 44.86  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  81 SLLELESSVSQLLADPNQETRKTVNDYLEGLNRRSRS-RAIYVMDTTGRVLATSNWRDADSYQGEDLSFRAYFQNAVRGQ 159
Cdd:cd18773    6 LLLRSLASALEALAALGSADREELQALLRRLLERNPEiSGIYVVDADGRVVASSDRDPGGGDDDDDRDRFWYQAAKATGK 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 504530029 160 P--GRFYgIGSTNGEPGYYLAHGLE-EHGKIIGVAVVKVRL 197
Cdd:cd18773   86 LviSEPY-ISRVTGKPVITLSRPIRdADGRFIGVVGADIDL 125
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 409-475 2.10e-05

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 42.58  E-value: 2.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504530029  409 AIGQMSTSIAHELNQPLAALRTlsgnTVRFLERGAL-DTASTNLKTINELIDRMGRITASLRSFARRG 475
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRG----YLELLRDEKLdEEQREYLETILRSAERLLRLINDLLDLSRIE 64
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 409-475 3.83e-05

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 41.78  E-value: 3.83e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504530029   409 AIGQMSTSIAHELNQPLAALRTlsgnTVRFLERGALDTASTN-LKTINELIDRMGRITASLRSFARRG 475
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRG----YLELLLDTELSEEQREyLETILREAERLLRLINDLLDLSRIE 64
PRK10337 PRK10337
sensor protein QseC; Provisional
 418-615 4.18e-05

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 46.57  E-value: 4.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 418 AHELNQPLAALRTLSgnTVRFLergALDTASTNLKTINEL---IDRMGRITASLRSFARRgddQGEASLGKAVDAAFQVL 494
Cdd:PRK10337 245 AHELRSPLAALKVQT--EVAQL---SDDDPQARKKALLQLhagIDRATRLVDQLLTLSRL---DSLDNLQDVAEIPLEDL 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 495 garldsLPLTVHRDFANAQ-------LQID--------QTRLEQILV-NLIGNALDAMQAQAVPQLWLEGQsgdgkyRLL 558
Cdd:PRK10337 317 ------LQSAVMDIYHTAQqagidvrLTLNahpvirtgQPLLLSLLVrNLLDNAIRYSPQGSVVDVTLNAR------NFT 384

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 504530029 559 VRDNGHGIDPEARKHLFEPFFtTKPGEQ--GLGLGLTLSASLAAATGGSLAVEHPANGG 615
Cdd:PRK10337 385 VRDNGPGVTPEALARIGERFY-RPPGQEatGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
312-481 3.29e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  312 DLRRAAINQGILVAVAFGLVAFLLIAWNERRKVIATRLAAREALQEANS---QLERRIAERTADLRASNERLKGQIRERR 388
Cdd:COG4913   637 EAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDdlaALEEQLEELEAELEELEEELDELKGEIG 716

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029  389 QAEETLRRAQDELVQA-GKLAAIGQMSTSIAHEL--NQPLAALRTLSGNTVRFLERGALDTASTNL-KTINELIDRMGRI 464
Cdd:COG4913   717 RLEKELEQAEEELDELqDRLEAAEDLARLELRALleERFAAALGDAVERELRENLEERIDALRARLnRAEEELERAMRAF 796

                         170
                  ....*....|....*..
gi 504530029  465 TASLRSFARRGDDQGEA 481
Cdd:COG4913   797 NREWPAETADLDADLES 813
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 517-624 3.86e-04

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 43.68  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 517 DQTRLEQILVNLIGNALD-----------AMQAQAVPQLWLEGQsgdgkyrllVRDNGHGIDPEARKHLFEPF------F 579
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKftesgnidilvELRALSNTKVQLEVQ---------IRDTGIGISERQQSQLFQAFrqadasI 475

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 504530029 580 TTKPGeqGLGLGLTLSASLAAATGGSLAVEHPANGGTAFVLNLPL 624
Cdd:PRK11107 476 SRRHG--GTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPL 518
mutl TIGR00585
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 528-582 7.33e-04

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 42.24  E-value: 7.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 504530029  528 LIGNALDAMQAQAVPQLWlegqsGDGKYRLLVRDNGHGIDPEARKHLFEPFFTTK 582
Cdd:TIGR00585  30 LVENSLDAGATRIDVEIE-----EGGLKLIEVSDNGSGIDKEDLPLACERHATSK 79
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
417-623 7.49e-04

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 42.26  E-value: 7.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 417 IAHELNQPLAALRtLSgntVRFLERgaldTASTNLKTINELIDRMGRITASLRSFARRGDD--QGEASLGKAVDAAFQVL 494
Cdd:PRK10755 144 VAHELRTPLAGIR-LH---LELLEK----QHHIDVAPLIARLDQMMHTVEQLLQLARAGQSfsSGHYQTVKLLEDVILPS 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 495 GARLDSL------PLTVHRDFANAQLQIDQTRLEQILVNLIGNALDAMQAQAVPQLWLEGQsgDGKYRLLVRDNGHGIDP 568
Cdd:PRK10755 216 QDELSEMleqrqqTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQE--DGGAVLAVEDEGPGIDE 293

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 504530029 569 EARKHLFEPFFTTKPGEQGLGLGLTLSASLAAATGGSLAVE-HPANGGTAFVLNLP 623
Cdd:PRK10755 294 SKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQnRQERSGTRAWVWLP 349
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-623 7.52e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 39.33  E-value: 7.52e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504530029 552 DGKYRLLVRDNGHGIDPEARKHLFEpffTTKPGEQGLGLGL-TLSASLAAATG--GSLAVEHPANGGTAFVLNLP 623
Cdd:cd16957   35 QHKVHVSVSDNGQGIPEERLDLLGK---TTVTSEKGTGTALeNLNRRLIGLFGseACLHIESEVHGGTEVWFVIP 106
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 528-582 1.08e-03

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 40.50  E-value: 1.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504530029 528 LIGNALDAmQAQAVpQLWLEGQsgdGKYRLLVRDNGHGIDPEARKHLFEPFFTTK 582
Cdd:cd16926   21 LVENSIDA-GATRI-DVEIEEG---GLKLIRVTDNGSGISREDLELAFERHATSK 70
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
 322-461 1.23e-03

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 39.77  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504530029 322 ILVAVAFGLVAFLL--IAW-------NERRKVIATRLAAREALQEANSQLERRIAERTADLRASNERLKGQIRER--RQA 390
Cdd:COG0711    4 FWQLINFLILVLLLkkFAWppilkalDERQEKIADGLAEAERAKEEAEAALAEYEEKLAEARAEAAEIIAEARKEaeAIA 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504530029 391 EETLRRAQDElvqAGKLAAIGQmsTSIAHELNQPLAALRTLSGNTV-----RFLERGAldTASTNLKTINELIDRM 461
Cdd:COG0711   84 EEAKAEAEAE---AERIIAQAE--AEIEQERAKALAELRAEVADLAvaiaeKILGKEL--DAAAQAALVDRFIAEL 152
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 549-623 3.85e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 36.76  E-value: 3.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504530029 549 QSGDGKYRLLVRDNGHGIDPEARkhlfepffttkPGEQGLGLgltlsASL---AAATGGSLAVEHPANGGTAFVLNLP 623
Cdd:cd16917   26 SYTADELTLTVVDDGVGFDGPAP-----------PGGGGFGL-----LGMrerAELLGGTLTIGSRPGGGTRVTARLP 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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