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Conserved domains on  [gi|504448013|ref|WP_014635115|]
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MULTISPECIES: acetate kinase [Streptococcus]

Protein Classification

acetate kinase( domain architecture ID 10011301)

acetate kinase catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.1
Gene Ontology:  GO:0008776|GO:0016310|GO:0000287|GO:0006085|GO:0005524
PubMed:  16678422

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-397 0e+00

acetate kinase A/propionate kinase 2; Reviewed


:

Pssm-ID: 234680  Cd Length: 402  Bit Score: 675.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   3 KTIAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFDD-RSESQTLDIADHVQAVKILLDDLI--RFDIIKS 79
Cdd:PRK00180   2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGgEKEEEELPIPDHAEALKFLLNTLTdgKLGLIKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  80 YDEITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYR 159
Cdd:PRK00180  82 LDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 160 YPVPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTR 239
Cdd:PRK00180 162 YALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 240 TGDLDPAIIPFVIDREPeMaDAECIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGV 319
Cdd:PRK00180 242 SGDIDPAIIPYLMEKLG-M-SVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAA 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 320 LNG-ADAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN---VFGHVGDITTAESAVKVFVIPTDEELVIARDVERLK 395
Cdd:PRK00180 320 LNGrLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNlaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRLL 399


                 ..
gi 504448013 396 TK 397
Cdd:PRK00180 400 GK 401
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-397 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 675.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   3 KTIAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFDD-RSESQTLDIADHVQAVKILLDDLI--RFDIIKS 79
Cdd:PRK00180   2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGgEKEEEELPIPDHAEALKFLLNTLTdgKLGLIKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  80 YDEITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYR 159
Cdd:PRK00180  82 LDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 160 YPVPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTR 239
Cdd:PRK00180 162 YALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 240 TGDLDPAIIPFVIDREPeMaDAECIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGV 319
Cdd:PRK00180 242 SGDIDPAIIPYLMEKLG-M-SVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAA 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 320 LNG-ADAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN---VFGHVGDITTAESAVKVFVIPTDEELVIARDVERLK 395
Cdd:PRK00180 320 LNGrLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNlaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRLL 399


                 ..
gi 504448013 396 TK 397
Cdd:PRK00180 400 GK 401
AckA COG0282
Acetate kinase [Energy production and conversion];
3-394 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 655.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   3 KTIAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKF-DDRSESQTLDIADHVQAVKILLDDLIRFDIIKSYD 81
Cdd:COG0282    2 KILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGIIKDLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  82 EITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRYP 161
Cdd:COG0282   82 EIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 162 VPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRTG 241
Cdd:COG0282  162 LPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 242 DLDPAIIPFVIDREpEMaDAECIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLN 321
Cdd:COG0282  242 DIDPGVVLYLMRKE-GL-SADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALG 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504448013 322 GADAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN-VFGHVGDITTAESAVKVFVIPTDEELVIARDVERL 394
Cdd:COG0282  320 GLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANaARGGERVISTPDSRVKVLVIPTNEELMIARDTLRL 393
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 6-394 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 587.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   6 AINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFDDRSESQT-LDIADHVQAVKILLDDLIRFDIIKSYDEIT 84
Cdd:cd24010    3 VINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEeLPIPDHEEALKAILDTLTDPELGVSLDEID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  85 GVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRYPVPN 164
Cdd:cd24010   83 AVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYALPY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 165 RYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRTGDLD 244
Cdd:cd24010  163 ELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGDID 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 245 PAIIPFVIDREpEMADAEcIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLNGAD 324
Cdd:cd24010  243 PAIVFYLMKKE-GMSVDE-IERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504448013 325 AIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN--VFGHVGDITTAESAVKVFVIPTDEELVIARDVERL 394
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNkaAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-389 1.96e-175

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 494.25  E-value: 1.96e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013    3 KTIAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFD-DRSESQTLDIADHVQAVKILLDDLIRFDIIKSYD 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNgGKKNAALLAGADHSEALNFILNTLLKHKIIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   82 EITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRYP 161
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  162 VPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRTG 241
Cdd:pfam00871 161 LPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  242 DLDPAIIPFVIDREPEMADAecIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLN 321
Cdd:pfam00871 241 DIDPAIIFYLAETLGMSADE--INNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLE 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504448013  322 GADAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN-VFGHVGDITTAESAVKVFVIPTDEELVIAR 389
Cdd:pfam00871 319 RLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNnRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-394 1.22e-172

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 487.69  E-value: 1.22e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013    1 MTKTIAINAGSSSLKWQLYEMP-DEVVLAKGLIERIGLKDS-VSTVKFDDRSESQTLDIADHVQAVKILLDDLIRFDIIK 78
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVnGEEVLASGLAERIFLPNArIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIIK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   79 SYDEITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKEL--LPDITSVAVFDTAFHTSMPEV 156
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLfpLPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  157 AYRYPVPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMM 236
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  237 GTRTGDLDPAIIPFVIDREPEMADAecIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQY 316
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGMSADD--IENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  317 FGVLNGA-DAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKNV---FGHVGDITTAESAVKVFVIPTDEELVIARDVE 392
Cdd:TIGR00016 321 IASLEGNlDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaarSGKSGVISTPESKVKILVIPTNEELMIAQDAI 400


                  ..
gi 504448013  393 RL 394
Cdd:TIGR00016 401 RL 402
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-397 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 675.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   3 KTIAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFDD-RSESQTLDIADHVQAVKILLDDLI--RFDIIKS 79
Cdd:PRK00180   2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGgEKEEEELPIPDHAEALKFLLNTLTdgKLGLIKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  80 YDEITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYR 159
Cdd:PRK00180  82 LDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 160 YPVPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTR 239
Cdd:PRK00180 162 YALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 240 TGDLDPAIIPFVIDREPeMaDAECIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGV 319
Cdd:PRK00180 242 SGDIDPAIIPYLMEKLG-M-SVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAA 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 320 LNG-ADAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN---VFGHVGDITTAESAVKVFVIPTDEELVIARDVERLK 395
Cdd:PRK00180 320 LNGrLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNlaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRLL 399


                 ..
gi 504448013 396 TK 397
Cdd:PRK00180 400 GK 401
AckA COG0282
Acetate kinase [Energy production and conversion];
3-394 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 655.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   3 KTIAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKF-DDRSESQTLDIADHVQAVKILLDDLIRFDIIKSYD 81
Cdd:COG0282    2 KILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGIIKDLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  82 EITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRYP 161
Cdd:COG0282   82 EIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 162 VPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRTG 241
Cdd:COG0282  162 LPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 242 DLDPAIIPFVIDREpEMaDAECIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLN 321
Cdd:COG0282  242 DIDPGVVLYLMRKE-GL-SADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALG 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504448013 322 GADAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN-VFGHVGDITTAESAVKVFVIPTDEELVIARDVERL 394
Cdd:COG0282  320 GLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANaARGGERVISTPDSRVKVLVIPTNEELMIARDTLRL 393
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 6-394 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 587.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   6 AINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFDDRSESQT-LDIADHVQAVKILLDDLIRFDIIKSYDEIT 84
Cdd:cd24010    3 VINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEeLPIPDHEEALKAILDTLTDPELGVSLDEID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  85 GVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRYPVPN 164
Cdd:cd24010   83 AVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYALPY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 165 RYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRTGDLD 244
Cdd:cd24010  163 ELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGDID 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 245 PAIIPFVIDREpEMADAEcIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLNGAD 324
Cdd:cd24010  243 PAIVFYLMKKE-GMSVDE-IERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504448013 325 AIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN--VFGHVGDITTAESAVKVFVIPTDEELVIARDVERL 394
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNkaAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-389 1.96e-175

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 494.25  E-value: 1.96e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013    3 KTIAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFD-DRSESQTLDIADHVQAVKILLDDLIRFDIIKSYD 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNgGKKNAALLAGADHSEALNFILNTLLKHKIIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   82 EITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRYP 161
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  162 VPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRTG 241
Cdd:pfam00871 161 LPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  242 DLDPAIIPFVIDREPEMADAecIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLN 321
Cdd:pfam00871 241 DIDPAIIFYLAETLGMSADE--INNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLE 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504448013  322 GADAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN-VFGHVGDITTAESAVKVFVIPTDEELVIAR 389
Cdd:pfam00871 319 RLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNnRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-394 1.22e-172

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 487.69  E-value: 1.22e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013    1 MTKTIAINAGSSSLKWQLYEMP-DEVVLAKGLIERIGLKDS-VSTVKFDDRSESQTLDIADHVQAVKILLDDLIRFDIIK 78
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVnGEEVLASGLAERIFLPNArIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIIK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   79 SYDEITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKEL--LPDITSVAVFDTAFHTSMPEV 156
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLfpLPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  157 AYRYPVPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMM 236
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  237 GTRTGDLDPAIIPFVIDREPEMADAecIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQY 316
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGMSADD--IENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  317 FGVLNGA-DAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKNV---FGHVGDITTAESAVKVFVIPTDEELVIARDVE 392
Cdd:TIGR00016 321 IASLEGNlDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaarSGKSGVISTPESKVKILVIPTNEELMIAQDAI 400


                  ..
gi 504448013  393 RL 394
Cdd:TIGR00016 401 RL 402
PRK12397 PRK12397
acetate/propionate family kinase;
3-394 2.46e-166

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 471.63  E-value: 2.46e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   3 KTIAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFDDRSESQTLDIADHVQAVKILLDDLIRFDIIKSYDE 82
Cdd:PRK12397   4 KIMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADAQVTIKTHSQKWQETVPVADHRDAVTLLLEKLLGYQIINSLRD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  83 ITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRYPV 162
Cdd:PRK12397  84 IDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAYIYPL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 163 PNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRTGD 242
Cdd:PRK12397 164 PWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGTRSGD 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 243 LDPAIIPFVIDREPEMADAecIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLNG 322
Cdd:PRK12397 244 IDPSILPWIAQREGKTPQQ--LNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQMGG 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504448013 323 ADAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKNVfgHVGDITTAESA-VKVFVIPTDEELVIARDVERL 394
Cdd:PRK12397 322 LDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQ--RNATFIQTENAlVKVAVINTNEELMIAQDVMRI 392
PRK07157 PRK07157
acetate kinase; Provisional
 1-394 1.05e-143

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 414.14  E-value: 1.05e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   1 MTKTIAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFDDRSESQTLDIADHVQAVKILLDDLIRFDIIKSY 80
Cdd:PRK07157   2 KAKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLENGLIKIKFGKKKYEKEVDMPNHKVAVAVLIEIWEENKLIEDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  81 DEITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRY 160
Cdd:PRK07157  82 EEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINYTY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 161 PVPNRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKpiEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRT 240
Cdd:PRK07157 162 PINYEIAKKYGIKKYGFHGISHKFITNKVEKILNK--DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTRS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 241 GDLDPAIIPFVIdREPEMADAEcIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVL 320
Cdd:PRK07157 240 GDIDPSIHEFVA-KEANMSISE-FTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKI 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 321 NGA-DAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKNV-----FGHVGDITTAESAVKVFVIPTDEELVIARDVERL 394
Cdd:PRK07157 318 GKKiDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLkkigeYGPIELISTPDSDIPVYVIRTNEELLIAKNAIKL 397
PRK12379 PRK12379
propionate kinase;
7-394 2.44e-123

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 362.13  E-value: 2.44e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   7 INAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKfddRSESQTLDIADHVQAVKILLDDLIRFDIIKSydeITGV 86
Cdd:PRK12379  10 INCGSSSIKFSVLDASDCEVLMSGIADGINSENAFLSVN---GGEPAPLAHHSYEGALKAIAFELEKRNLNDS---VALI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  87 GHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRYPVPNRY 166
Cdd:PRK12379  84 GHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGLPWEY 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 167 YTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRTGDLDPA 246
Cdd:PRK12379 164 YEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVDFG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 247 IIPFVIDREPE-MADAEcirHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLNGADA 325
Cdd:PRK12379 244 AMAWIASQTGQtLGDLE---RVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLHRLDG 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504448013 326 IVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKN-VFGHVGD--ITTAESAVKVFVIPTDEELVIARDVERL 394
Cdd:PRK12379 321 IIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNnQPNSGGEriISSENSRVICAVIPTNEEKMIALDAIHL 392
PRK12440 PRK12440
acetate/propionate family kinase;
5-389 1.19e-112

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 334.91  E-value: 1.19e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   5 IAINAGSSSLKWQLYEMPDEVVLAKGLIERIGLKDSVSTVKFDDRSESQTLDIADHVQavKILLDDLIRF-DIIKSYDEI 83
Cdd:PRK12440   7 LVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLEDARMSWKYQGEKTEIAIEGEDNHH--KIAIGRLVGLtEELGFTQDI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  84 TGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVAYRYPVP 163
Cdd:PRK12440  85 VAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAFTGAIA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 164 NRYYTDYQVRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMGTRTGDL 243
Cdd:PRK12440 165 KELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGTRCGDL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 244 DPAIIPFVIDREPEMadaECIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLNGA 323
Cdd:PRK12440 245 DPGIIEFLLKKGWSQ---EKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAALDSL 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 324 DAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKNV---FGHVGDITTAES-AVKVFVIPTDEELVIAR 389
Cdd:PRK12440 322 DGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEdarFGKAGIIAKSELlNAVAMVIPTNEEFVIAQ 391
PRK07058 PRK07058
acetate/propionate family kinase;
8-390 4.28e-94

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 287.33  E-value: 4.28e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   8 NAGSSSLKWQLYEMPDEVV--LAKGLIERIGlkdsvSTVKFDDRSESQTLDI---ADHVQAVKILLDDLIR-----FDIi 77
Cdd:PRK07058  10 NAGSSTVKIGLFEVDGNEArrIGKGDIDFRR-----APLRFHLRNGGETLDIplkASVTDDLHTVLDETFDwlaahFDV- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  78 ksyDEITGVGHRVVAGGEYFKESSLVDEDALAKIEELSALAPLHNPGAASGIRAFKELLPDITSVAVFDTAFHTSMPEVA 157
Cdd:PRK07058  84 ---SELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQPDLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 158 YRYPVPnRYYTDYQVRKYGAHGTSHQYVSQEAAKlLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLTPLGGVMMG 237
Cdd:PRK07058 161 RRFAIP-RALHDEGIKRYGFHGLSYKFVAGELRR-RAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGIPMA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 238 TRTGDLDPAIIPFVIDREPEMADAecIRHVFNKESGLLGISEKSSDMRDIIAGKNAGDEKcvlAYNLYVDRLRKYIAQYF 317
Cdd:PRK07058 239 TRCGALDPGVVLHLLKQEGMSLDE--VEDLLYHRSGLLGVSGISGDTRDLLASDAPEARE---ALDLFALRIAGEIARLA 313

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504448013 318 GVLNGADAIVFTAGIGENSAEVRASVLDGLTWFGIEVDPEKNVfGHVGDITTAESAVKVFVIPTDEELVIARD 390
Cdd:PRK07058 314 ATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANA-ANAFTISSRTSRVAAFVIPTDEEQVIADE 385
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 173-351 8.88e-21

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 92.21  E-value: 8.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 173 RKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKSVDTSMGLtPLGGVMMGTRTGDLD-PAIIPFV 251
Cdd:cd24011  147 RRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGTLPvGDLIKLC 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 252 IDREPemaDAECIRHVFNKESGL---LGIseksSDMRDIIAGKNAGDEKCVLAYNLYVDRLRKYIAQYFGVLNG-ADAIV 327
Cdd:cd24011  226 FSGKY---TLEELKKKLKGKGGLvayLGT----NDFREVEKRIEAGDEKAKLVLDAMAYQIAKEIGALAAVLKGkVDAII 298

                        170       180
                 ....*....|....*....|....
gi 504448013 328 FTAGIGeNSAEVRASVLDGLTWFG 351
Cdd:cd24011  299 LTGGLA-YSKRLVDRIKERVGFIA 321
PRK03011 PRK03011
butyrate kinase; Provisional
 1-332 3.96e-15

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 75.97  E-value: 3.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013   1 MTKTIAINAGSSSLKWQLYEmpDEVVLAKGlieriglkdsvsTVKFDDRSESQTLDIADHVQA-VKILLDDLIRFDI-IK 78
Cdd:PRK03011   1 MMRILVINPGSTSTKIAVFE--DEKPIFEE------------TLRHSAEELEKFKTIIDQYEFrKQAILDFLKEHGIdLS 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013  79 SYDEITGVGH--RVVAGGEYfkessLVDE----DALAKI--EELSALAPL--HNPGAASGIRAF-------KELLPdits 141
Cdd:PRK03011  67 ELDAVVGRGGllKPIPGGTY-----RVNEamleDLKNGKygEHASNLGAIiaYEIAKELGIPAFivdpvvvDEMEP---- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 142 VAVFdtafhTSMPEVAyrypvpnryytdyqvRKYGAHGTSHQYVSQEAAKLLGKPIEETKIITAHVGNGVSITAVDGGKS 221
Cdd:PRK03011 138 VARI-----SGLPEIE---------------RKSIFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRV 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504448013 222 VDTSMGLtPLGGVMMGTRTGDLdPAiIPFVidrepEMA-----DAECIRHVFNKESGL---LGisekSSDMRDIIAGKNA 293
Cdd:PRK03011 198 IDVNNAL-DGEGPFSPERAGGL-PV-GDLV-----ELCfsgkyTKEELKKKLVGKGGLvayLG----TNDAREVEKRIEE 265

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 504448013 294 GDEKCVLAYNLYVDRLRKYIAQYFGVLNG-ADAIVFTAGI 332
Cdd:PRK03011 266 GDEKAKLVYEAMAYQIAKEIGAMAAVLKGkVDAIVLTGGL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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