|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
20-423 |
7.89e-114 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 339.70 E-value: 7.89e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 20 LATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLQGtiy 99
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQA--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 100 lYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFYYIGA 179
Cdd:TIGR00893 78 -FAGAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 180 IGVILGIVWLFKVRDPLQHPKVNQEEIEYIRDGGGEPALGSKKAQEkITLAQFKSVCINRMMIGVYIGQFCVTSITWFFL 259
Cdd:TIGR00893 157 LGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPST-PKKYQIKELLKDRRVWGLALGQFLVNIGLGFFL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 260 TWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRGYSLTVARKLPVICGMLLSCVIVIANYTSSEIVV 339
Cdd:TIGR00893 236 TWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 340 VAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTQSFDYAILYVGSMGLLGLISY 419
Cdd:TIGR00893 316 LALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSY 395
|
....
gi 504406155 420 LFIV 423
Cdd:TIGR00893 396 LLLV 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-422 |
6.74e-99 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 299.87 E-value: 6.74e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 11 RYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSL 90
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 91 VTMLQGTIYLYASplivLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSW 170
Cdd:cd17319 81 FTALTGFATSLTS----LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 171 HYVFYYIGAIGVILGIVWLFKVrdplqhpkvnqeeieyirdgggepalgskkaqekitlaqfksvcinRMMIGVYIGQFC 250
Cdd:cd17319 157 RWAFIIEGLLGLLLAVLWWFYL----------------------------------------------RQVWGLALGYFG 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 251 VTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALlkrgysLTVARKLPVICGMLLSCVIVIA 330
Cdd:cd17319 191 INYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL------LRGARRLVIIIGLLLAAVGLLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 331 NYTS-SEIVVVAAMSVAFFAKGFGNLGWCVLSDTS-PKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTQSFDYAILYV 408
Cdd:cd17319 265 AYLTtSPVVAVILLSLAGFGIGAASPVFWSLPADLlPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFL 344
|
410
....*....|....
gi 504406155 409 GSMGLLGLISYLFI 422
Cdd:cd17319 345 AAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-428 |
3.42e-63 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 207.80 E-value: 3.42e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 6 KRTKVRYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCAL 85
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 86 IGWSLVTMLQGtiylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIIL 165
Cdd:COG2271 83 LLWGLATLLFG----FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 166 HNLSWHYVFYYIGAIGVILGIVwlfkvrdplqhpkvnqeeieyirdgggepalgskkaqekitlaqfksvcinrMMIGVY 245
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLALL----------------------------------------------------RFWLLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 246 IGQFCVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRgysltvaRKLPVICGMLLSC 325
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAA 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 326 V-IVIANYTSSEIVVVAAMSVAFFAKGFGN-LGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTqSFDY 403
Cdd:COG2271 260 LaLLLLALLPSPALAIALLFLAGFGLGGAFgLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQA 338
|
410 420
....*....|....*....|....*
gi 504406155 404 AILYVGSMGLLGLISYLFIVGPLER 428
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETRK 363
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-395 |
1.91e-56 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 190.66 E-value: 1.91e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 19 FLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLQGti 98
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 99 ylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPL-MTIILHNLSWHYVFYYI 177
Cdd:TIGR00881 79 --FSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLvLFGIAELYSWHWVFIVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 178 GAIGVILGIVWLFKVRDPLQHPKVNQEEIEYIRDGGGEPALGSKKAQEKITLAQFksVCINRMMIGVYIGQFCVTSITWF 257
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQY--VLLNKVLWYISLGYVFVYVVRTG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 258 FLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLK-RGYSLTVARKLPVICGMLLSCVIVIANYTSse 336
Cdd:TIGR00881 235 ILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNgRRGPLAVFFMALIIVSLLVYWLNPAANPLM-- 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 504406155 337 iVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIIL 395
Cdd:TIGR00881 313 -DLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLA 370
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
18-421 |
1.16e-46 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 164.26 E-value: 1.16e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 18 LFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLqgT 97
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL--T 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 98 IYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISL---GIITPLMtiiLHNLSWHYVF 174
Cdd:cd17380 82 PLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTllgGLIGPLL---LEYYGWPSVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 175 YYIGAIGVILGIVWLFKVRdplqhpkvnqeeieyirdgggepalgskkaqekitlaqfkSVCinrmmiGVYIGQFCVTSI 254
Cdd:cd17380 159 YFFGLLGLLWALVWLIYLP----------------------------------------PVW------AIIVAHFCMNWG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 255 TWFFLTWFPTYLYQAKGmSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRGYSLTVARKLPVICGMLLSCV-IVIANYT 333
Cdd:cd17380 193 FYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALfLLLLSHT 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 334 SSEIVVVAAMSVAFFAKGFGNLG-WCVLSDTSPKEVlGIAGGVFNMCGNMASIVTPLVIGIILANTQSFDYAILYVGSMG 412
Cdd:cd17380 272 DSFSLALLCMSVALGLSAFSSSGvLVNHQDIAPNYA-GIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVN 350
|
....*....
gi 504406155 413 LLGLISYLF 421
Cdd:cd17380 351 LVGAVVFLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-422 |
2.16e-40 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 148.49 E-value: 2.16e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 9 KVRYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGW 88
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 89 SLVTMLQGtiylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNL 168
Cdd:COG2223 81 GIGLLLLA----LAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 169 SWHYVFYYIGAIGVILGIVWLFKVRDPLQHPkvnqeeieyirdgggepalgskKAQEKITLAQFKSVCINRMMIGVYIGQ 248
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRDPPAGA----------------------AAAAKASLRDQLEALRDPRFWLLSLLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 249 FCVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDallKRGysltvARKLPVICGMLLS-CVI 327
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD---RIG-----GRRVLLIVFALMAlGLL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 328 VIANYTSSEIVVVAAMSVAFFAKGFGN-LGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTQSFDYAIL 406
Cdd:COG2223 287 LLALALGSLWLFLVLFLLLGLALGGGNgAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFL 366
|
410
....*....|....*.
gi 504406155 407 YVGSMGLLGLISYLFI 422
Cdd:COG2223 367 VFAVLALVALVLTLLL 382
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
16-402 |
8.98e-33 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 127.74 E-value: 8.98e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 16 LFLFLATVFNYADRATLSVVAPFMSQ----------------------ELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLD 73
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAIVAMVNstathdnnntstdkdtlpveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 74 RYGARMVYGCALIGWSLVTMLqgTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYIS 153
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLL--TPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 154 LGIITPLMTIILHNLSWHYVFYYIGAIGVILGIVWLFKVRdplqhpkvnqeeieyirdgggePALGskkaqekITLAQFK 233
Cdd:cd17318 160 TVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL----------------------PVWA-------IVVAHFG 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 234 SVCinrmmiGVYIgqfcvtsitwfFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRG-YSLTVA 312
Cdd:cd17318 211 HNW------GFYT-----------LLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGiLSTTTV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 313 RKLPVICGMLLS--CVIVIANYTSSEIVVVAAMSVAFFAKGFGNLGWCV-LSDTSPKEVlGIAGGVFNMCGNMASIVTPL 389
Cdd:cd17318 274 RKLFTSIGFLGPgvFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVnHLDLAPNYA-GTLMGITNTAATIAGIISPL 352
|
410
....*....|...
gi 504406155 390 VIGIILANTQSFD 402
Cdd:cd17318 353 IVGAIVKNDQTIG 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-388 |
1.75e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 120.22 E-value: 1.75e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 18 LFLATVFNYADRATLSVVAP-FMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTmlqg 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 97 TIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFYY 176
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 177 IGAIGVILGIVWLFKVRDPLQHPKVNQEEIEYIRDGGgepalgskkaqekitlaqFKSVCINRMMIGVyIGQFCVTSITW 256
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA------------------WKALLRDPVLWLL-LALLLFGFAFF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 257 FFLTWFPTYLyQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRgysltvaRKLPVICGMLLSCVIVIANYTSSE 336
Cdd:pfam07690 218 GLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 504406155 337 IVVVAAMSVAFFAKGFGNLGWCVL---SDTSPKEVLGIAGGVFNMCGNMASIVTP 388
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNalvSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-420 |
2.09e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 112.52 E-value: 2.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 18 LFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLQGT 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 98 IYLYASplivLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNL--SWHYVFY 175
Cdd:cd06174 81 APSFWL----LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 176 YIGAIGVILGIVWLFKVRDPLQHPKVNQEEIEyirdgggepalgskkaqEKITLAQFKSVCINRMMIGVYIGQFCVTSIT 255
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEAS-----------------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 256 WFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRGYSLTVArklpviCGMLLSCVIVIANYTSS 335
Cdd:cd06174 220 YSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG------LLLMALGLALLLLAPSL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 336 EIVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTQSFDYAILYVGSMGLLG 415
Cdd:cd06174 294 LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLA 373
|
....*
gi 504406155 416 LISYL 420
Cdd:cd06174 374 AILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-384 |
1.71e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 103.52 E-value: 1.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 6 KRTKVRYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCAL 85
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 86 IGWSLVTMLQGTiylyASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIIL 165
Cdd:COG2814 83 LLFALGSLLCAL----APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 166 HNLSWHYVFYYIGAIGVILGIVWLFKVRDPLQHPKVNQeeieyirdgggepalgskkaqekitLAQFKSVCINRMMIGVY 245
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARL-------------------------RGSLRELLRRPRLLLLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 246 IGQFCVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDallkrgyslTVARKLPVICGMLLSC 325
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD---------RFGRRRLLLIGLLLLA 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504406155 326 V--IVIANYTSSEIVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMAS 384
Cdd:COG2814 285 LglLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
11-420 |
1.34e-23 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 101.20 E-value: 1.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 11 RYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSL 90
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 91 VTMLQGTIYLYAspliVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSW 170
Cdd:cd17312 81 ANIFMGFSTSLW----FFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 171 HYVFYYIGAIGVILGIVWLFKVRDplqHPKVnqeeIEYIrdgggepalgskkaqekitlaqfkSVCINRMMIGVYIgqfc 250
Cdd:cd17312 157 RAAFLVPGIVGLVVAIILFFFLRD---SPPY----VWVL------------------------SLAYAFVYIVRYA---- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 251 vtsitwfFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKrgysltvARKLPVI----CGMLLSCV 326
Cdd:cd17312 202 -------CLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFG-------GRRAPIAviymLLMTLSLA 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 327 IVIANYTSSEIVVVAAMSVAFFAKGFGNLgWCVL--SDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTqSFDYA 404
Cdd:cd17312 268 LFWFFPHNKLLSIVLLFLIGFFVGGPINL-IGGAaaQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHY-GWSTV 345
|
410
....*....|....*.
gi 504406155 405 ILYVGSMGLLGLISYL 420
Cdd:cd17312 346 FYFLISAALLSVLLLL 361
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-401 |
2.08e-22 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 98.08 E-value: 2.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 18 LFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMV--YGCALIGWSLVTMLQ 95
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVlaVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 96 GTIYLYASPlivlviLRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFY 175
Cdd:cd17475 81 VGSYPVLLV------LLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 176 YIGAIGVILGIVWLFKVRDPlqhpkvnqeeieyirdgggePALGSKKAQEKITLAQFKSVCINRMMIGVYIGQFCVTSIT 255
Cdd:cd17475 155 VAGLVSILAAVLFWLFYREP--------------------PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 256 WFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRgysltvaRKLPVICGMLLSCVIVIA----N 331
Cdd:cd17475 215 FALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGG-------RRRPVLVITAAIAAAALLvlslL 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504406155 332 YTSSEIVVVAAMSVA--FFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTQSF 401
Cdd:cd17475 288 SPGTPLWLLVLLLILlgLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSY 359
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
37-423 |
9.11e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.11 E-value: 9.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 37 PFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLqgtiYLYASPLIVLVILRLLMG 116
Cdd:cd17325 20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL----FAFATSYWQLLLARFLQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 117 AIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFYYIGAIGVILGIVWLFKVRDPL 196
Cdd:cd17325 96 LASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 197 QHPKvnqeeieyirdgggepalgSKKAQEKITLAQFKSVCINRMMIGVYIGQFCVTSITWFFLTWFPTYLYQAKGMSILK 276
Cdd:cd17325 176 PPPN-------------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 277 VGFIASIPAIAGFVGGLLGGVFSDallKRGysltvaRKLPVICGMLLSCVIVIANYTSSEIV-VVAAMSVAFFAKGFGNL 355
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSD---RIG------RKPLILIGLLLSAVALLLLPLATSFWlLLLLLALLGLGLGLVFP 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504406155 356 GWCVL-SDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGiILANTQSFDYAILYVGSMGLLGLISYLFIV 423
Cdd:cd17325 308 ATLALlADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGG-FLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
47-395 |
2.86e-19 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 89.80 E-value: 2.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 47 PEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLqgtIYL-YASPLIVLVILRLLMGAIEAPAFPA 125
Cdd:TIGR00894 75 GALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIV---IPWaAGGGIALVVFCRVIQGLAQGSVSPA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 126 NSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIIL-HNLSWHYVFYYIGAIGVILGIVWL-FKVRDPLQHPKVNQ 203
Cdd:TIGR00894 152 THKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFvFPADDPSIHPCISK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 204 EEIEYIrdgggepalGSKKAQEKITLAQ---FKSVCINRMMIGVYIGQFCVTSITWFFLTWFPTYLYQAKGMSILKVGFI 280
Cdd:TIGR00894 232 FEKKYI---------NSSLQGQKGSTRQslpIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 281 ASIPAIAGFVGGLLGGVFSDALLKRGY-SLTVARKL-PVICGMLLSCVIVIANYTSSEIV-VVAAMSVAFFAKGFGNLGW 357
Cdd:TIGR00894 303 SSLPYLFAWLCSIFAGYLADFLKSSKTlSLTAARKIfNGIGGLGPGIFAYALPYLSAAFYlTIIILTLANAVSSGPLAGV 382
|
330 340 350
....*....|....*....|....*....|....*...
gi 504406155 358 CVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIIL 395
Cdd:TIGR00894 383 LINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNIL 420
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
11-394 |
1.31e-18 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 87.30 E-value: 1.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 11 RYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSL 90
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 91 VTMLQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPL---MTIILHN 167
Cdd:cd17345 81 INILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLaglGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 168 LSWHYVFYYIGAIGVILGIVWLFKVRDPLQHPKVNQEEiEYIRDGGGEPAlgSKKAQEKITLAQ--FKSVCINRMMIGVY 245
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIE-EYKGDYPEEAD--GEEEEQELSAWEifVKYVLKNKLLWYIA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 246 IGQFCVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDaLLKRGYsltvaRKLPVICGMLLS- 324
Cdd:cd17345 238 IANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSD-KLFKGR-----RAPTGIIFMILVi 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504406155 325 -CVIVIANYTSSEIVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGvfnMCGNMA----SIVTPLVIGII 394
Cdd:cd17345 312 vALIVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAG---LTGLFGylggSVLATALIGII 383
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
15-420 |
4.86e-17 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 82.67 E-value: 4.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 15 LLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTML 94
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 95 QGTIYLYASplivLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAqyISLG-----IITPLMTiiLHNLS 169
Cdd:cd17328 81 SSFAPNFWQ----LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFA--IPLGsglgyVVGGLVA--QATGG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 170 WHYVFYYIGAIGVILGIVWLFKVRDPlqhpkvnqeeieyiRDGGGEPALGSKKAQEKItLAQFKSVCINRMMIGVYIGQF 249
Cdd:cd17328 153 WRWAFRVTGVLGVLLAILLLLFVREP--------------PRGAAEGGVMAKSTATSF-LADLKALAKNPSFILSTLGFT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 250 CVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRgYSLTVARKLPVIC--GMLLSCVI 327
Cdd:cd17328 218 AVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADR-LRRKTPRADPLVCavGLLAAAPF 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 328 VIANYTSSEIVVVAAMSVAFFAKGFGNLGWCVLSD----TSPKEVLGIAGGVFNMCGNM-ASIVTPLVIGII-------- 394
Cdd:cd17328 297 LFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAillyVVIPTRRSTASAIQILLSHLlGDAGSPYLIGLIsdllrqnk 376
|
410 420
....*....|....*....|....*....
gi 504406155 395 ---LANTQSFDYAILYVGSMGLLGLISYL 420
Cdd:cd17328 377 dspLAEAASLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-388 |
6.44e-17 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 82.30 E-value: 6.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 9 KVRYSILLFLFLATVFNYADRATLSVVAPF-MSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIG 87
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 88 WSLVTMLQGTIYLYASplivLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISlGIITPLM-TIILH 166
Cdd:cd17327 81 WGLLTLLTAAVKNFGG----LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLG-SIFGGLLaYGVFK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 167 NL------SWHYVFYYIGAIGVILGIVWLFKVRDPLQHPK-VNQEEIEYIRDggGEPALGSKKAQEKITLAQFKSVCINR 239
Cdd:cd17327 156 ILgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWfLTEEEKELAVE--RLRANQTGKGDQKFKWKQIKEAFKDP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 240 MMIGVYIGQFCVTSITWFFLTWFPTYLyQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRGYSLTVArklpvIC 319
Cdd:cd17327 234 RTWLLFLFFFCSQITNNGISNFLPLIL-KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFA-----CV 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504406155 320 GMLLSCVIVIANYTSSEIVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTP 388
Cdd:cd17327 308 LALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
11-194 |
1.02e-14 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 75.13 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 11 RYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSL 90
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 91 VTMLQGtiylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSW 170
Cdd:cd17488 81 INILFG----FSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGW 156
|
170 180
....*....|....*....|....
gi 504406155 171 HYVFYYIGAIGVILGIVWLFKVRD 194
Cdd:cd17488 157 RAGMYVPGIIAILMGIVLCWRLRD 180
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
45-392 |
2.36e-14 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 74.43 E-value: 2.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 45 FDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLQ------GTIYLYAsplivlviLRLLMGAI 118
Cdd:cd17381 62 WDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTplaadlGAGYLIA--------VRALEGLG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 119 EAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFYYIGAIGVILGIVWLFKVRdPLQh 198
Cdd:cd17381 134 EGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVM-PLW- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 199 pkvnqeeieyirdgggepalgskkaqekitlaqfksvcinrmmiGVYIGQFCVTSITWFFLTWFPTYLYQAKGMSILKVG 278
Cdd:cd17381 212 --------------------------------------------AIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 279 FIASIPAIAGFVGGLLGGVFSDALL-KRGYSLTVARKLPVICGMLLSCV-IVIANYTS-SEIVVVAAMSVAFFAKGFGNL 355
Cdd:cd17381 248 FLSALPYLGCWLFMILSGQIADNLReKQNFSTVCVRKIFTLIGMIGPAVfLLAAGFTGcNYSLAVAFLTISSTLGGFSAS 327
|
330 340 350
....*....|....*....|....*....|....*...
gi 504406155 356 GWCVLS-DTSPKEVlGIAGGVFNMCGNMASIVTPLVIG 392
Cdd:cd17381 328 GFNINHlDIAPSYA-GILLGITNTFATIPGMVGPVIAK 364
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-195 |
2.17e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 70.23 E-value: 2.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 7 RTKVRYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALI 86
Cdd:COG0477 8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 87 GWSLVTMLQGtiylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILH 166
Cdd:COG0477 88 LFGLASLLCG----LAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180
....*....|....*....|....*....
gi 504406155 167 NLSWHYVFyYIGAIGVILGIVWLFKVRDP 195
Cdd:COG0477 164 ALGWRWIF-LINAPLGLLALVLRLRLPES 191
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
8-276 |
3.01e-13 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 71.28 E-value: 3.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 8 TKVRYSILLFLFLATVFNYADRATLSVVAPFMSQElGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIG 87
Cdd:PRK11273 24 RRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLIL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 88 WSLVTMLQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHN 167
Cdd:PRK11273 103 AAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLFLLGMAW 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 168 LS-WHYVFYYIGAIGVILGIVWLFKVRDPLQH---PKVNQEEIEYirdgggePALGSKKAQEKITLAQ--FKSVCINRMM 241
Cdd:PRK11273 183 FNdWHAALYMPAFAAILVALFAFAMMRDTPQScglPPIEEYKNDY-------PDDYNEKHEQELTAKQifMQYVLPNKLL 255
|
250 260 270
....*....|....*....|....*....|....*
gi 504406155 242 IGVYIGQFCVTSITWFFLTWFPTYLYQAKGMSILK 276
Cdd:PRK11273 256 WYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDK 290
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-420 |
1.45e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.40 E-value: 1.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 15 LLFLFLATVFNYADRATLSVVAPFMSQE--LGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVT 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 93 MLQGtiylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYI----SLGIITPLMTIILHNL 168
Cdd:cd17316 81 LLIG----LLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALgallAALVASLLIPLLSGDW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 169 SWHYVFYyIGAIGVILGIVwlfkvrdplqhpkvnqeeieyirdgggepalgskkaqekitlaqfksvcINRMMIGVYIGQ 248
Cdd:cd17316 157 GWRILFL-IGALPALLALL-------------------------------------------------LRRRTLLLILLW 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 249 FCVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDallkrgyslTVARKLPVICGMLLSCVIV 328
Cdd:cd17316 187 FFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD---------RIGRKKTLVIGLILSGILA 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 329 I----ANYTSSEIVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTQSFDYA 404
Cdd:cd17316 258 LplfyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVP 337
|
410
....*....|....*.
gi 504406155 405 ILYVGSMGLLGLISYL 420
Cdd:cd17316 338 ALILALLAIVALIVAL 353
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-192 |
1.31e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 65.68 E-value: 1.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 5 IKRTKVRYSILLFLFLATVFNYADRATLSVVAP-FMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGC 83
Cdd:cd17325 191 GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 84 ALIGWSLVTMLqgtiYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTI 163
Cdd:cd17325 271 GLLLSAVALLL----LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346
|
170 180
....*....|....*....|....*....
gi 504406155 164 ILHNLSWHYVFYYIGAIGVILGIVWLFKV 192
Cdd:cd17325 347 LYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
11-389 |
1.55e-11 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 65.82 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 11 RYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSL 90
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 91 VTMlqgtIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSW 170
Cdd:cd17343 81 TTV----AFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 171 HYVFYYIGAIGVILGIVWLFKVRDPLQHPKVNQEEIEYIRDGGGEPALGSKKAQEKITLAQFKSVCINRMmiGVYIGQFC 250
Cdd:cd17343 157 RSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYL--VVFGVKTA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 251 VTsitwfflTWFPTYLYQAKG---------MSILKV-GFIASIPAiagfvggllgGVFSD-ALLKRGYSLTVARKLPVI- 318
Cdd:cd17343 235 VT-------DWGQLFLIQDKGqsaltgssfMSSLEVgGFVGSIAA----------GYLSDwAVAKHGSSSRGNPRMPLAl 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504406155 319 -------CGMLLSCVIvIANYTSSEIVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPL 389
Cdd:cd17343 298 vfmagltVSLHLFRVH-ITSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGL 374
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
42-421 |
2.62e-11 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 64.67 E-value: 2.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 42 ELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLqgtiylyaSPLIVLVILRLLM------ 115
Cdd:cd17382 43 EFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNML--------IPIAARVHYGCVIfvrilq 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 116 GAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFYYIGAIGVILGIVWLFkvrdp 195
Cdd:cd17382 115 GLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWML----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 196 lqhpkvnqeeieyirdgggepalgskkaqekITLAQFksvcinrmmiGVYIGQFCVTSITWFFLTWFPTYLYQAKGMSIL 275
Cdd:cd17382 190 -------------------------------VSMPVY----------AIIVANFCRSWTFYLLLISQPAYFKEVFGFDIS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 276 KVGFIASIPAIAGFVGGLLGGVFSDALLKRGY-SLTVARKLpVICG------MLLSCViviaNYTSSEIVVVAAMSVAFF 348
Cdd:cd17382 229 KVGILSALPHLVMTIIVPIGGQLADYLRSRGIlSTTAVRKI-FNCGgfgmeaTFLLVV----AFSHSPTVAISFLVLAVG 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504406155 349 AKGFGNLGWCVLS-DTSPKE---VLGIAGGVfnmcGNMASIVTPLVIGIILAN--TQSFDYAILYVGSMGLLGLISYLF 421
Cdd:cd17382 304 FSGFAISGFNVNHlDIAPRYasiLMGISNGI----GTLSGMVCPVIVGALTKHktREEWQYVFLIASLVHFFGVIFYAI 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-395 |
8.84e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 63.14 E-value: 8.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 1 MNTIIKRTKVRYSILLFL--FLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGAR 78
Cdd:TIGR00895 3 QNNIRKQPLSRYQWRAIIlsFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 79 MVYGCALIGWSLVTMLQGTIYLYASPLIVLVILRLLMGAIeapaFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIIT 158
Cdd:TIGR00895 83 RVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL----MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 159 PLMTIILHNLSWHYVFYYIGAIGVIL----------GIVWLFKVRDPLQHPKVNQEEIEYIRDGGGE-PALGSKKAQEKI 227
Cdd:TIGR00895 159 FLAGWLIPVFGWRSLFYVGGIAPLLLllllmrflpeSIDFLVSKRPETVRRIVNAIAPQMQAEAQSAlPEQKSTQGTKRS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 228 TLAQFKSVCINRMMIGVYIGQFCVTSITWFFLTWFPTYLYQAkGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRGY 307
Cdd:TIGR00895 239 VFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 308 SLtvarkLPVICGMLLscVIVIANYTSSEIVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVT 387
Cdd:TIGR00895 318 AL-----LLLLGAVFA--VLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIG 390
|
....*...
gi 504406155 388 PLVIGIIL 395
Cdd:TIGR00895 391 PILAGYLL 398
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-424 |
1.80e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.10 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 1 MNTIIKRTKVRYSILLFLFLATVFNyadraTLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMV 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATA-----LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 81 YGCALIGWSLVTMLQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSvqwfpNKERGFVTSIYQSAQYISlGIITPL 160
Cdd:COG0738 76 LLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-----PETAASRLNLLHAFFSLG-ALLGPL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 161 MTIIL----HNLSWHYVFYYIGAIGVILGIVWLFKVRdplqhpkvnqeeieyirdgggePALGSKKAQEKITLAQFKSVC 236
Cdd:COG0738 150 LGGLLillgLSLSWHLPYLILAVLLLLLALLFLRSKL----------------------PEIEEEEEEAAGSAASLKSLL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 237 INRMMIGVYIGQFCVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAgfvgGLLGGVFSDALLKRgysLTVARKLP 316
Cdd:COG0738 208 KNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGG----MTIGRFLGGFLLKR---FGPVRLLR 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 317 VICGMLLSCVIVIANYTSSEIVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVlGIAGGVFNMCGNMASIVTPLVIGIILa 396
Cdd:COG0738 281 LSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLA- 358
|
410 420
....*....|....*....|....*...
gi 504406155 397 ntQSFDYAILYVGSMGLLGLISYLFIVG 424
Cdd:COG0738 359 --DAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-423 |
2.47e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.76 E-value: 2.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 18 LFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIgwslVTMLQGT 97
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLL----IFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 98 IYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFYYI 177
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 178 GAIGViLGIVWLFKVRDPLQHPKVNQEEieyirdgggepalgskkaqEKITLAQFKSVCINRMMIGVYIGQFCVTSITwf 257
Cdd:cd17489 157 AVLAL-LALLLVFLVKDPPPVAAEEAEA-------------------GTRAFRRLVEKKVLPPALILFLASIAYGAIS-- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 258 flTWFPTYlYQAKGMSilKVGFIASIPAIAGFVGGLLGGVFSDALLKRgyslTVArklpVICGMLLSCVIVIANYTSSEI 337
Cdd:cd17489 215 --TFLPLY-AAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPK----TVI----IPGLLLLALGLLLLSFAGSPW 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 338 VVVAAmsVAFFAKGFGNLGWCVLS---DTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTqSFDYAILYVGSMGLL 414
Cdd:cd17489 282 MLLLA--AVLYGLGFGLLFPALQAlavDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLL 358
|
....*....
gi 504406155 415 GLISYLFIV 423
Cdd:cd17489 359 ALVLYIFLL 367
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
11-194 |
3.18e-09 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 58.57 E-value: 3.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 11 RYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSL 90
Cdd:PRK11663 21 RRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 91 VTMLQGtiylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSW 170
Cdd:PRK11663 101 INILFG----FSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGW 176
|
170 180
....*....|....*....|....
gi 504406155 171 HYVFYYIGAIGVILGIVWLFKVRD 194
Cdd:PRK11663 177 RYGMMIAGIIAIVVGLFLCWRLRD 200
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-400 |
7.23e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.18 E-value: 7.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 14 ILLFLFLATVFNyadrATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTM 93
Cdd:cd17321 1 LLLAVFLAALDV----TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 94 LQGtiylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYV 173
Cdd:cd17321 77 LCA----LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 174 FYyigaIGVILGIVWLFkvrdplqhpkvnqeeieyirdgggepalgskkaqekitlaqfksvcINRMMIGVYIGQFCVTS 253
Cdd:cd17321 153 FL----INVPIGLVALL----------------------------------------------LARTFSGAVLAAFLLGA 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 254 ITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDallKRGYsltvarKLPVICGMLLSCVIVIANYT 333
Cdd:cd17321 183 ALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLAD---RFGP------RLVLVAGLLLTAVGLLLLAL 253
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504406155 334 SSEIVVVAAMSVAFFAKGFGN-LGWCVLSDTS----PKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTQS 400
Cdd:cd17321 254 LGADSSVWLLLPGLVLLGLGLgLFATPLTNAAlssvPKEKAGAASGILNTARQLGGALGVALLGALLTAGLS 325
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
14-195 |
9.90e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 56.90 E-value: 9.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 14 ILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGAR--MVYGCALIGWSLV 91
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRrvMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 92 TMLQGTiylyaSPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWH 171
Cdd:cd17355 84 LLALAT-----SLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
170 180
....*....|....*....|....*
gi 504406155 172 YVFYYIGAIGVILGI-VWLFKVRDP 195
Cdd:cd17355 159 TALLVLALLALLVLVpVLLLLRRRP 183
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
15-426 |
1.06e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 56.93 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 15 LLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTML 94
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 95 QGtiylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPL----MTIILHNLSW 170
Cdd:cd17371 81 CG----FAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLaallFPLLPPEIAW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 171 HYVFYyIGAIGVILGIVWLFKVRDPlqhpkvnqEEIEYIRDGGGEPALGSKKA--QEKITLaqfksvcinRMMIGVYIGQ 248
Cdd:cd17371 157 RVLFL-LGALPALLVLFIRRFVKEP--------PQWQAARAARRHFADRPSLRelFSPPLL---------RTTLLASLLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 249 FCVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALlkrgysltvARKLPVICGMLLSCVIV 328
Cdd:cd17371 219 TGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI---------GRRNNFALFALGSAISI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 329 --IANYTSS-EIVVVAAMSVAFFAKG-FGNLGWcVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGiILANTQSFDYA 404
Cdd:cd17371 290 llYFFLPLSpTLILILGFPLGFFASGpFSGMGA-YLTELFPTAVRATAQGFCYNVGRIIGALFPFLVG-FLATSGSLGTA 367
|
410 420
....*....|....*....|..
gi 504406155 405 IlyvgsmGLLGLISYLFIVGPL 426
Cdd:cd17371 368 I------AVFAAVYYIAGLVLA 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-397 |
1.09e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 18 LFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVygcaLIGWSLVTMLQGT 97
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKV----LLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 98 IYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAqyISLGIIT-PLMTIILHNLSWHYVFYY 176
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAA--LGLGIAVgPLLGGLLAAISWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 177 IGAIGVILGIVWLFKVRDPLQHpkvnqeeieyirdgggepalgsKKAQEKITLAQFKSVCINRMMIGVYIGQFCVTSITW 256
Cdd:cd17474 158 LAALIPVAFLAILFLLPEPKEK----------------------AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 257 FFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVfsdaLLKRGYSltvARKLPVICGMLLSCVIVIANYTSSE 336
Cdd:cd17474 216 AFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGR----LLKKRFG---ARRILVIGLLLYALSLLLLGFVPSL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504406155 337 IVVVAAMSVAFFAKGFGN-LGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILAN 397
Cdd:cd17474 289 ALLLIAIVLFGLGLGLNLpLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
7-437 |
1.36e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.45 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 7 RTKVRYSiLLFLFLATVFNyadrATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGAR-------M 79
Cdd:COG2211 10 KEKLAYG-LGDLGLNLAFG----LLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrpwI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 80 VYGCALIG------WSLVTMLQGTIYLYAspLIVLVILRLLMGAIEAPAFPANSRLSVqwfPNKERGFVTSIYQSAQYIS 153
Cdd:COG2211 85 LIGAIPLAlsfvllFTAPDLSPTGKLIYA--LVTYLLLGLAYTLVNIPYSALGAELTP---DYEERTRLSSWRFAFAGLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 154 LGIITPLMTIILHNLS------WHYVFYYIGAIGVILGIVWLFKVRDPLQHPKVNQEEIEYIRDGGGEPALgskkaqeki 227
Cdd:COG2211 160 GLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPF--------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 228 tlaqfksvcinRMMIGVYIGQFCVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLlggvfsdALLKRgy 307
Cdd:COG2211 231 -----------LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP-------RLAKR-- 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 308 sltVARKLPVICGMLLSCVIVIANY---TSSEIVVVAAMSVAFFAKGFGN-LGWCVLSDTSPKEVL-------GIAGGVF 376
Cdd:COG2211 291 ---FGKKKAFIIGLLLAALGLLLLFflgPGNLWLLLVLAALAGIGLGAILvLPWAMLADVVDYDEWktgrrreGLYFGIF 367
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504406155 377 NMCGNMASIVTPLVIGIILANT-------QSFDYAILYVGSMGLLGLISYLFIVGPLERITLTSTKPE 437
Cdd:COG2211 368 TFAIKLGQALAGALAGLLLALFgyvagaaQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHA 435
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
30-421 |
1.93e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 1.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 30 ATLSVVAPFMSQELGFDPEAM-GLAFSAFGIAYVIMQLPGGWLLDRYGARMVygcaLIGWSLVTMLQGTIYLYASPLIVL 108
Cdd:cd17473 16 AAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRL----LIAGLLLYGIGGVAGLFLDSLYAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 109 VILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISlGIITPLMTIILHNLSWHYVFYyIGAIGVILGIVW 188
Cdd:cd17473 92 LASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLG-GVVFLLLGGALAEIGWRAPFL-VYLLALPVLILV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 189 LFKVRDPlqhpkvnqeeieyirdgggEPALGSKKAQEKITLAQFKsvciNRMMIGVYIGQFCVTSITWFFLTWFPTYLYQ 268
Cdd:cd17473 170 LLFLPEP-------------------ARKSKSAASPGAATAAALP----WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 269 AKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRgysltvarKLPVICGMLLSCVIVIANYTSSEIVVVAAMSVAFF 348
Cdd:cd17473 227 RGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKR--------RLLAIGFALMALGFLLLALASGLWVVLLGAILAGL 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504406155 349 akGFGNLGWCVLS---DTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTQSFDYAILYVGSMGLLGLISYLF 421
Cdd:cd17473 299 --GFGLLLPTLNSwamSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
15-190 |
7.64e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.09 E-value: 7.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 15 LLFLFLATVFNYADRATL-SVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALigwsLVTM 93
Cdd:cd17324 200 LRLAYLITFLLFGGFFALyTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALL----LLAA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 94 LQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPnKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYV 173
Cdd:cd17324 276 ALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGV 354
|
170
....*....|....*..
gi 504406155 174 FyYIGAIGVILGIVWLF 190
Cdd:cd17324 355 G-WVGAALLLLALLLAL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
37-420 |
8.65e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.71 E-value: 8.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 37 PFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLQGTIYLYASPLIVLVILRLLMG 116
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 117 AIEAPAFPANSRLsvqwFPNKERGFVTSIYQSAqyISLGIIT--PLMTIILHNLSWHYVFYYIGAIGVILGIVWLFKVrd 194
Cdd:cd17324 103 GFWAIAAAYAADL----VPPEKRGRAIGLVFSG--LTLGLVLgrPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 195 plqhpkvnqeeieyirdgggePALGSKKAQEKITLAQFKSVCINRMMIGVYIGQFCVTSITWFFLTWFPTYLYQAKGMSI 274
Cdd:cd17324 175 ---------------------PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 275 LKVGFIASIPAIAGFVGGLLGGVFSDALLKRgySLTVArklPVICGMLLSCVIVIANYTSSEIVVVAAMSVAFFAKGFGN 354
Cdd:cd17324 234 SAIIGLLLLFGVAGVVGSPLAGRLADRGGRR--ALLIA---LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504406155 355 LGWcvLSDTSPkEVLGIAGGVFNMCGNMASIVTPLVIGIILANTqSFDYAILYVGSMGLLGLISYL 420
Cdd:cd17324 309 QTR--VLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-422 |
5.54e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 5.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 6 KRTKVRYSILLFLFLATVFNYadRATLSVVAPF---MSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVyg 82
Cdd:COG2807 10 RSRRAGRWLLLLAIVLVALNL--RPAITSVGPLlpeIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERT-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 83 calIGWSLVTMLQGTIYLYASPLIVLVILRLLMG----AIEAPAFPAnsrLSVQWFPNKeRGFVTSIYQSAQYISLGIIT 158
Cdd:COG2807 86 ---LLLALLLLAAGLLLRSLAPSVALLLAGTALIgagiAVGNVLLPG---LIKRWFPDR-VGLMTGLYTAAMGLGAALAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 159 PLMTIILHNLSWHYVFYYIGAIGVILGIVWLFKVRdplqhpkvnqeeieyiRDGGGEPALGSKkaqekitlAQFKSVCIN 238
Cdd:COG2807 159 GLTVPLAAALGWRGALAVWALLALLALLLWLPLLR----------------RRPAAAAAAPAA--------ASLRSLWRS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 239 RMMIGVYIGQFCVTSITWFFLTWFPTYLyQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRgysltvaRKLPVI 318
Cdd:COG2807 215 PLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR-------RPLLLL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 319 CG--MLLSCVIVIANYTSSEIVVVAAMSVAFFAkGFGnLGWCVLSDTSP-KEVLGIAGGVFNMCGNMASIVTPLVIGIIL 395
Cdd:COG2807 287 LGllGLAGLLGLLLAPGSLPWLWAVLLGLGQGG-LFP-LALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALH 364
|
410 420
....*....|....*....|....*..
gi 504406155 396 ANTQSFDYAILYVGSMGLLGLISYLFI 422
Cdd:COG2807 365 DATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
14-190 |
9.23e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 9.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 14 ILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLD-RYGARMVYGCALIGWSLVT 92
Cdd:cd17474 200 LLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 93 mlqgTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHY 172
Cdd:cd17474 280 ----LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA 355
|
170
....*....|....*...
gi 504406155 173 VFYYIGAIGVILGIVWLF 190
Cdd:cd17474 356 PFLVGAAIALAAAVLLAL 373
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
33-195 |
2.18e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 49.53 E-value: 2.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 33 SVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGAR--MVYGCALIGWSLVTMLQGTIYLYAsplivLVI 110
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRkaILIGGILFGLGFILSAFAISLPLL-----FLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 111 LRLLMGAIEAPAFPANSRLSVQWFPNKeRGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFYYIGAIGVILGIVWLF 190
Cdd:cd17353 98 YGVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAF 176
|
....*
gi 504406155 191 KVRDP 195
Cdd:cd17353 177 LIRDP 181
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
13-191 |
4.95e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 48.34 E-value: 4.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 13 SILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLP-GGWLLDRYGARmvygCALIGWSLV 91
Cdd:cd17330 175 PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGER----KLLRLGLLL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 92 TMLQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISlGIITPLMTIILHNLSWH 171
Cdd:cd17330 251 AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLA-RIIGPLLAGPLYSFLGP 329
|
170 180
....*....|....*....|
gi 504406155 172 YVFYYIGAIGVILGIVWLFK 191
Cdd:cd17330 330 GVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
7-191 |
5.04e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 5.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 7 RTKVRYSILLFLFLATVFNYADRATLSVVAPFMSQE-LGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCAL 85
Cdd:cd06173 202 RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 86 IGWSLVTMLQGtiylYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIIL 165
Cdd:cd06173 282 LLLGLALLVLG----LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA 357
|
170 180
....*....|....*....|....*.
gi 504406155 166 HNLSWHYVFYYIGAIGVILGIVWLFK 191
Cdd:cd06173 358 DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
30-421 |
8.56e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.70 E-value: 8.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 30 ATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGAR--MVYGCALIGWSLVTMLQG-TIYLYASpli 106
Cdd:cd17333 13 ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRrtLILGLLLISLALALIFATpSIYLFVV--- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 107 VLVILRLLMGAIEAPAFPansrlsvqwfpnkergFVTSIYQSAQYISL----------GIITPLMT--IILHNLSWHYVF 174
Cdd:cd17333 90 LMFLAGLGAGILDTGANT----------------FVGALFEESSATRLnvlhgffglgALIGPLIAtsLLTSELSWSWAY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 175 YYIGAIGVILGIVWLFKVRDPLQHPKvnqeeieyirdgggePALGSKKAQEKITLAQFKsvciNRMMIGVYIGQFCVTSI 254
Cdd:cd17333 154 LIIGLIYLLLAILILLTLFPELPSAR---------------NPQQSVGAFSASASRLLR----NPSIILGALALFLYVGA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 255 TWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRGYSLTVarklpVICGMLLSCVIVIANYts 334
Cdd:cd17333 215 ETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLS-----GSGALLGLLILLLAPT-- 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 335 seivvVAAMSVAFFAKGF--GNLGWCVLSDTS---PKEVlGIAGGVFNMCGNMASIVTPLVIGIIlANTQSFDYAILYVG 409
Cdd:cd17333 288 -----LVVGLVATALLGLfmAALFPTILSLGIsnlPYAK-GKGTSVLLAAGSIGGAIIPFIMGFI-AEAVGIQTAMLLIT 360
|
410
....*....|..
gi 504406155 410 SMGLLGLISYLF 421
Cdd:cd17333 361 ILYAIIFVLALL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
3-156 |
9.97e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 9.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 3 TIIKRTKVRYSILLFLFLATVFNyadraTLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYG 82
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFF-----GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504406155 83 CALIGwSLVTMLQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGI 156
Cdd:pfam07690 270 LALLL-LILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-200 |
3.58e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.64 E-value: 3.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 14 ILLFLFLATVFNYAdrATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTM 93
Cdd:COG2223 209 LLSLLYFGTFGSFI--GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 94 LqgtIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIIL-HNLSWHY 172
Cdd:COG2223 287 L---LALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdATGSYTA 363
|
170 180
....*....|....*....|....*...
gi 504406155 173 VFYYIGAIgVILGIVWLFKVRDPLQHPK 200
Cdd:COG2223 364 AFLVFAVL-ALVALVLTLLLYRRPRRAA 390
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
244-437 |
6.58e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 6.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 244 VYIGQFCVTSITWFFLTWFPTYLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALlkrgysltvARKLPVICGMLL 323
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 324 SCV--IVIANYTSSEIVVVAAMSVAFFAKGFGNLGWCVLSDTSPKEVLGIAGGVFNMCGNMASIVTPLVIGIILANTqSF 401
Cdd:pfam07690 72 FALglLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GW 150
|
170 180 190
....*....|....*....|....*....|....*.
gi 504406155 402 DYAILYVGSMGLLGLISYLFIVGPLERITLTSTKPE 437
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-194 |
8.64e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.49 E-value: 8.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 32 LSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLQGTiylyASPLIVLVIL 111
Cdd:cd17503 15 VNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL----APNLASLIIF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 112 RLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAqyISLG-IITPLMT-IILHNLSWHYVFYY---IGAIGVILGI 186
Cdd:cd17503 91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLV--ILLApAIGPTLGgWLTDNLSWRWIFYInlpIGILALLLAP 168
|
170
....*....|.
gi 504406155 187 V---WLFKVRD 194
Cdd:cd17503 169 LldlRLFKDRN 179
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
51-187 |
1.36e-04 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 43.90 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 51 GLAFSAFGIAYVIMQLPGGWLLDRYGARMVygcALIgwSLVTMLQGTIYLYASPLIVLVILRLLM-GAIEAPAFPANSRL 129
Cdd:PRK12382 252 GFTLTAFGGAFVLMRVLFGWMPDRFGGVKV---AIV--SLLVETVGLLLLWLAPTAWVALAGAALtGAGCSLIFPALGVE 326
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 504406155 130 SVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFyYIGAIGVILGIV 187
Cdd:PRK12382 327 VVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVF-LAGAISAVLGII 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-187 |
2.83e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 2.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 11 RYSILLFLFLATVFNYADRATLSVVAP-FMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRY-GARMVYGCALIGW 88
Cdd:cd06174 201 KNPGLWLLLLAIFLVNLAYYSFSTLLPlFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLM 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 89 SLVTMLqgtiYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIIL-HN 167
Cdd:cd06174 281 ALGLAL----LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaAT 356
|
170 180
....*....|....*....|
gi 504406155 168 LSWHYVFYYIGAIGVILGIV 187
Cdd:cd06174 357 FGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
32-414 |
4.14e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.24 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 32 LSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTMLQGTIYLYASPLIVLVIL 111
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 112 RLLMGAIEAPAFPANSRlsvqWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLS-------WHYVFYYIGAIGVIL 184
Cdd:cd17341 98 LGFAGANFASGQPWASF----WFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVfdggfvgWRNAFFVPGILLAIA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 185 GIVWLFKVRDPLQHPKVNQEEIEYIRDGGGEPALgskkaqekITLAQFKSVCinrmmIGVYIGqfcvtsitwfFLTWFPT 264
Cdd:cd17341 174 AVLVLLFGDDLPTGKASALEFLKVQLAVLKNYRT--------WILSLLYGVT-----FGSFVG----------FSNVLPT 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 265 YLYQAKGMSILKVGFIASIPAIAGFVGGLLGGVFSDALLKRGYSLTVarkLPVICGMLLSCVIVIANYTSSEIVVVAAMS 344
Cdd:cd17341 231 YFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWL---FIVMTIGAALLSLSLPTSGTNLVLFLALFV 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504406155 345 VAFFAKGFGN-LGWCVLSDTSPKEvLGIAGGVFNMCGNMASIVTPLVIGIILANTQSFDYAILYVGSMGLL 414
Cdd:cd17341 308 ALGLGAGAGNgSVFRMVPFIFRRE-LGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVA 377
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
34-76 |
4.49e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 42.26 E-value: 4.49e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 504406155 34 VVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYG 76
Cdd:PRK11551 36 VAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIG 78
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-422 |
4.91e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 4.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 15 LLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGAR--MVYGCALIGWSLVT 92
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrlLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 93 MLqGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHY 172
Cdd:cd06173 81 LA-LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 173 VFyYIGAIGVILGIVWLFKVRDPLQHPKVNQEEIEYIRDGGGepalGSKKAQEKITLAQFKSVCINRMMIGVYIGQfcvt 252
Cdd:cd06173 160 AF-AINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG----LRYLRRSPLLRLLLLALALFALLGGALTVL---- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 253 sitwffltwFPTYLYQAKGMSILKVGFIASIPAIAgfvggllgGVFSDALLKRGYSLTVARKLPVICGMLLSCVIVIANY 332
Cdd:cd06173 231 ---------LPLLAKEVLGGGAAGYGLLLAAFGVG--------ALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 333 TSSEIVVVAAMSVAFFAKGFGNLGWCVLSDTS-PKEVLGIAGGVFNMcGNMASIVTPLVIGIILANTQSFDYAILYVGSM 411
Cdd:cd06173 294 SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRvPDELRGRVFSVYNA-LNSGAMPLGALLAGLLADALGLSAVFLLAGAL 372
|
410
....*....|.
gi 504406155 412 GLLGLISYLFI 422
Cdd:cd06173 373 LLLAALLLLLL 383
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
5-190 |
7.98e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 7.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 5 IKRTKVRYSILLFLFLATVFN--YADRATLSvvapFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYG 82
Cdd:cd17370 193 TSLKKLPKAFWLYLLAVALFAlgNFSFAFLI----LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 83 CALIGWSLVTMLQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSvqwfPNKERGFVTSIYQSAQYISLGIITPLMT 162
Cdd:cd17370 269 LGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLV----PAELRGTAYGLFNTVVGIGWLLASLIAG 344
|
170 180
....*....|....*....|....*...
gi 504406155 163 IILHNLSWHYVFYYiGAIGVILGIVWLF 190
Cdd:cd17370 345 YLWDLISPSAAFLF-SAVLALIALLLLL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
30-188 |
1.02e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 30 ATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVY-GCALIGwslvTMLQGTIYLYASPLIVL 108
Cdd:cd17477 205 GAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLlGCALLG----ALAALLLPLVPGLPLAL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 109 VILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQyiSLG-IITPLMT-IILHNLSWHYVFYYIGAIGVILGI 186
Cdd:cd17477 281 LVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLY--GLGsVIGPLLAgALMDAFGPHGLFLFLAAVALLFLL 358
|
..
gi 504406155 187 VW 188
Cdd:cd17477 359 FL 360
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
10-187 |
1.22e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 10 VRYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWS 89
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 90 LVTMLQGtiYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLS 169
Cdd:cd17316 255 ILALPLF--YLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
|
170
....*....|....*...
gi 504406155 170 WHYVFYYIGAIGVILGIV 187
Cdd:cd17316 333 GTGVPALILALLAIVALI 350
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
36-192 |
1.38e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.63 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 36 APFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGAR--MVYGCALIGWSLVTMLQGTIYLYASPLIVLVILRL 113
Cdd:cd17359 220 GPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKplLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 114 LMGAIeapAFPANSRLSVQW------FPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHYVFYYIGAIGVILGIV 187
Cdd:cd17359 300 ILLFV---AFFAMSWGPVTWvllseiFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFLF 376
|
....*
gi 504406155 188 WLFKV 192
Cdd:cd17359 377 VWKFV 381
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
13-193 |
1.43e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 40.83 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 13 SILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVT 92
Cdd:TIGR00711 2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 93 MLQGTiylyASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKERGFVTSIYQSAQYISLGIITPLMTIILHNLSWHY 172
Cdd:TIGR00711 82 LLCGV----APNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRW 157
|
170 180
....*....|....*....|.
gi 504406155 173 VFYYIGAIGVILGIVWLFKVR 193
Cdd:TIGR00711 158 IFLINVPIGIIVVVVAFFILP 178
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
7-199 |
4.08e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.09 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 7 RTKVRYSILLFLFLATVFNYadratlSVVA--PFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGAR--MVYG 82
Cdd:COG2807 213 RSPLAWLLTLFFGLQSLLYY------AVVAwlPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrpLLLL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 83 CALIgwslvtMLQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPN-KERGFVTSIYQSAQYIsLGIITPLM 161
Cdd:COG2807 287 LGLL------GLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYL-LAALGPLL 359
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 504406155 162 TIILHNL--SWHYVFYYIGAIGVILGIVWLFKVRDPLQHP 199
Cdd:COG2807 360 VGALHDAtgSWTAALLLLAALAVLMLVAGLLAGRPYVEDA 399
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
2-186 |
4.23e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 4.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 2 NTIIKRTKVRYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVy 81
Cdd:cd17478 184 SSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRV- 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 82 gcalIGWSLVTMLQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPNKeRGFVTSIYQSAQYISLGIITPLM 161
Cdd:cd17478 263 ----IIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVL 337
|
170 180
....*....|....*....|....*
gi 504406155 162 TIILHNLSWHYVFYYIGAIGVILGI 186
Cdd:cd17478 338 GALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
2-190 |
6.69e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.46 E-value: 6.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 2 NTIIKRTKVRYSILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVy 81
Cdd:cd17333 189 SASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTL- 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 82 gcaLIGWSLVTMLQGTIYLYASPLIVLVILRLLMGAIEAPAFPANSRLSVQWFPnKERGFVTSIYQSAQYISLGIITPLM 161
Cdd:cd17333 268 ---LVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIM 343
|
170 180
....*....|....*....|....*....
gi 504406155 162 TIILHNLSWHYVFYYIGAIGVILGIVWLF 190
Cdd:cd17333 344 GFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
16-94 |
7.07e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.60 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 16 LFLFLATVFNYAD--RATLSVVAPFMSQELGFDPEAMGLA-----FSAFGIAYVimqlpGGWLLDRYGARMVYGCALIGW 88
Cdd:COG2270 240 LLRFLLAYFFYRDgvQTVIAFAGIYAAGVLGFSTTELIVFgllvqIVAALGALL-----FGRLDDRIGPKRVILVSLVIW 314
|
....*.
gi 504406155 89 SLVTML 94
Cdd:COG2270 315 IVVCLA 320
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
15-94 |
7.82e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.34 E-value: 7.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 15 LLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARMVYGCALIGWSLVTML 94
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
32-300 |
8.46e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 8.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 32 LSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGARmvygcALIGWSLVTMLQGTIYLYASPLIVLVIL 111
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRR-----YLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 112 RLLMGAIEAPAF-PANSRLSVQWFPNKeRGFVTSIYQSAQYISLGIiTPLMTIILHNLSWHYVFYYIGAIGVILGIVWLF 190
Cdd:cd17478 90 LVALAGIGSAAFhPEGARLASQAAGGR-RGLAMSIFSVGGNLGFAL-GPLIAAALVALFGGLGLLILLIIPGLAVALLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406155 191 KVRDPLQHPKVNQEEIEYIRDGGGEPALGskkaqekitlaqfksvcINRMMIGVYIGQFCVTSITwfflTWFPTYLyQAK 270
Cdd:cd17478 168 RLRPLKKPEAKKAAAKSSARSTLKGVWRA-----------------LLLLLIIVFLRSWVLSSLT----TFLPFYL-VQR 225
|
250 260 270
....*....|....*....|....*....|
gi 504406155 271 GMSILKVGFIASIPAIAGFVGGLLGGVFSD 300
Cdd:cd17478 226 GYSLVFAGLLLSLFLFAGAIGTLIGGPLSD 255
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
13-87 |
9.86e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.01 E-value: 9.86e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504406155 13 SILLFLFLATVFNYADRATLSVVAPFMSQELGFDPEAMGLAFSAFGIAYVIMQLPGGWLLDRYGAR-MVYGCALIG 87
Cdd:cd17393 200 LLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVaVLRAGALLA 275
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