|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
24-429 |
3.74e-154 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 442.74 E-value: 3.74e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 24 KRAALVSFVGSMLEYYDFFIYGTAAALIFPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLLFT 103
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 104 LVLMGGSTLAIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLV 183
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 184 FIPVSSLP-EDQLLSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAQVARFPVVTLLRDYW-PDVLRVIVCALI 261
Cdd:cd17369 161 FLLLSALLsDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWrALLLAIGLRLAE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 262 ATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMLVTSGNT 341
Cdd:cd17369 241 NVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGST 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 342 LAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGF-LAAGFTPLVSASLVGEGpNGWIPVAIFVACCC 420
Cdd:cd17369 321 WLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAiLGGGFAPLIATALVAAT-GSWWPVALYLAALA 399
|
....*....
gi 504305614 421 VISAASAAT 429
Cdd:cd17369 400 VISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
33-423 |
2.84e-94 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 289.56 E-value: 2.84e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 33 GSMLEYYDFFIYGTAAALIFPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVLMGGSTL 112
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 113 AIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLVFIPVSSLP- 191
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 192 EDQLLSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAQVARFPVVTLLRDYWPDVLRVI-VCALIATVSTMTAV 270
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTKHRKPFLLGLgLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 271 FALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMLVTSGNTLAIFAAAMI 350
Cdd:TIGR00883 241 YLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504305614 351 LSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQL-GFLAAGFTPLVSASLVGEGpNGWIPVAIFVACCCVIS 423
Cdd:TIGR00883 321 GMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLaGAIFGGFAPYIAAALVAMT-GDWYAIGYYLAALALIG 393
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
2-436 |
8.56e-85 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 266.60 E-value: 8.56e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 2 TLTSTAPLRASSSAEAApnklpKRAALVSFVGSMLEYYDFFIYGTAAALIFPKVFFANVDPSTATLLALLSFGIGYIARP 81
Cdd:PRK09952 4 TLISTRPDEGTLSLSRA-----RRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 82 VGAVILGHFGDRIGRKTVLLFTLVLMGGSTLAIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSN 161
Cdd:PRK09952 79 LGGVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 162 RAFFTSWTLSGTQAGAILAT-LVFIPVSSLPEDQLLSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAQVA--R 238
Cdd:PRK09952 159 KAFYSSGVQVGYGVGLLLSTgLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAkkR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 239 FPVVTLLRDYwPDVLRVIVCALIATVSTMTAV--FALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKP 316
Cdd:PRK09952 239 IPVIEALLRH-PGAFLKIIALRLCELLTMYIVtaFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRR 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 317 VFIGGVLGCAVLVFPYFMLVTSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLG-FLAAGFTP 395
Cdd:PRK09952 318 VYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVAsVVGGGFTP 397
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 504305614 396 LVSASLVGEGPNGWIPVAIFVACCCVISAASAATARETHNV 436
Cdd:PRK09952 398 FIAAALVTYFGGSWHSVAIYLLAGCLISAMTALLMKDNQRA 438
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
32-433 |
2.98e-65 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 214.85 E-value: 2.98e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 32 VGSMLEYYDFFIYGtAAALIFPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVLMGGST 111
Cdd:cd17367 6 VGNLVEWYDWYVYA-AFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 112 LAIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLV-FIPVSSL 190
Cdd:cd17367 85 LVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVlLVLQHTL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 191 PEDQLLSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAqVARFPVVTLLRDYWPDVLRVIVCALIATVSTMT-A 269
Cdd:cd17367 165 GEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESN-EASAGTLRELRRHPRELLLVVGLTAGGTLAFYTwT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 270 VFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMLVTSGNTLAIFAAAM 349
Cdd:cd17367 244 TYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALV 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 350 ILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFT-PLVSASLVGEGPNGWIPvaIFVACCCVISAASAA 428
Cdd:cd17367 324 LVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTaPYVALWLKSIGHEWVFF--WYVAGLIAISLVVYL 401
|
....*
gi 504305614 429 TARET 433
Cdd:cd17367 402 RMPET 406
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
24-435 |
4.31e-59 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 201.09 E-value: 4.31e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 24 KRAALVSFVGSMLEYYDFFIYGTAAaLIFPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLLFT 103
Cdd:PRK10642 15 RKAITAASLGNAMEWFDFGVYGFVA-YALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAIT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 104 LVLMGGSTLAIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAIL-ATL 182
Cdd:PRK10642 94 IVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLgAGV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 183 VFIPVSSLPEDQLLSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDK---------AQVARFPVVTLLRDYWPDVL 253
Cdd:PRK10642 174 VVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKleqgdreglQDGPKVSFKEIATKHWRSLL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 254 rviVCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVL----GNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLV 329
Cdd:PRK10642 254 ---TCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLiiiaIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVLA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 330 FPYFMLVTSGNTLAIFAAAMILSgVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLVGEGPNGW 409
Cdd:PRK10642 331 IPAFILINSNVIGLIFAGLLMLA-VILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESTQNLM 409
|
410 420
....*....|....*....|....*.
gi 504305614 410 IPvAIFVACCCVISAASAATARETHN 435
Cdd:PRK10642 410 MP-AYYLMVVAVIGLITGVTMKETAN 434
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
32-433 |
1.63e-56 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 191.03 E-value: 1.63e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 32 VGSMLEYYDFFIYGTAAALIfPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVLMGGST 111
Cdd:cd17366 6 LGNAMEWFDFGVYGYLAVTI-GKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAAST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 112 LAIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAIL-ATLVFIPVSSL 190
Cdd:cd17366 85 FCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILgAGLVTLLTLLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 191 PEDQLLSWGWRIPFLLSALVLLVAYLVRRtmpetpvfedikdkaqvarfpvvtllrdywpDVLRVIVCALIATVST-MTA 269
Cdd:cd17366 165 TEAQMLDWGWRIPFLIAAPLGLVGLYLRR-------------------------------PLLICIGLVLVFNVTNyMLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 270 VFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMLVTSGNTLAIFAAAM 349
Cdd:cd17366 214 SYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAIFIGLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 350 ILsGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGF-LAAGFTPLVSASLVGEGPNGWIPvAIFVACCCVISAASAA 428
Cdd:cd17366 294 VL-GLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVsLFGGTTPLVASWLVSATGNPLMP-AYYLMVAAVVGLVAVL 371
|
....*
gi 504305614 429 TARET 433
Cdd:cd17366 372 FLTET 376
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
33-433 |
2.33e-54 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 186.43 E-value: 2.33e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 33 GSMLEYYDFFIYGTAAALIfPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVLMGGSTL 112
Cdd:cd17368 7 GNALEFFDFGVYGFFAVYI-GRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 113 AIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLVFIPVS-SLP 191
Cdd:cd17368 86 LIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSlTLT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 192 EDQLLSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAQVARFpvVTLLRDYWPDVLRVIVCALIATVST-MTAV 270
Cdd:cd17368 166 AEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRREL--FALLANNRRIILLGMLLVAGSTVTFyFTTV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 271 FALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMLVTSGNTLAIFAAAMI 350
Cdd:cd17368 244 YTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFGRLLLVLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 351 LSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLA-AGFTPLVSASLVGEGPNGWIPvAIFVACCCVISAASAAT 429
Cdd:cd17368 324 VLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIfGGFAQFIVTWLIELTGSPLAP-AWYLMGAALLGLLATLM 402
|
....
gi 504305614 430 ARET 433
Cdd:cd17368 403 LRET 406
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-428 |
2.82e-47 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 166.24 E-value: 2.82e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 27 ALVSFVGSMLEYYDFFIYGTAAALIFpkvffANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVL 106
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLA-----AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 107 MGGSTLAIGLLPDaktignaaPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLVFIP 186
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 187 VSSLPEDqllSWGWRIPFLLSALVLLVAYLVRRTMpetpvfedikdkaqvarfpvvtllrdywpdVLRVIVCALIATVST 266
Cdd:cd17316 148 LIPLLSG---DWGWRILFLIGALPALLALLLRRRT------------------------------LLLILLWFFISFGYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 267 MTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMLVTSGNTLAIFA 346
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 347 AAMIlsGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLVGEGPnGWIPVAIFVACCCVISAAS 426
Cdd:cd17316 275 LFIL--SFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG-GTGVPALILALLAIVALIV 351
|
..
gi 504305614 427 AA 428
Cdd:cd17316 352 AL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
13-402 |
6.68e-39 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 145.47 E-value: 6.68e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 13 SSAEAAPNKLPKRAALVSFV--GSMLEYYDFFIYGTAAALIfPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHF 90
Cdd:PRK15075 1 MSTMTPAASRESKARAILRVtsGNFLEMFDFFLFGFYATAI-AKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 91 GDRIGRKTVLLFTLVLMGGSTLAIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTl 170
Cdd:PRK15075 80 IDRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQ- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 171 SGTQAGAIL--ATLVFIPVSSLPEDQLLSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAQVARfpVVTLLRDY 248
Cdd:PRK15075 159 SASQQVAVVfaALLGYLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMRE--IFRSLAAN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 249 WpdvlRVIVCALIATVSTMTAVFALGYATSKFGVARPTM-----LWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVL 323
Cdd:PRK15075 237 W----RIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLsaadsLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 324 GCAVLVFPYFMLVTSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLG-FLAAGFTPLVSASLV 402
Cdd:PRK15075 313 LAILTAYPALSWLVAAPSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLAtAIFGGFTPAISTWLI 392
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
33-391 |
2.01e-24 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 104.89 E-value: 2.01e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 33 GSMLEYYDFFIYgTAAALIFPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVLMGGSTL 112
Cdd:PRK10406 30 GNLVEWFDFYVY-SFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMMCFGSL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 113 AIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSW---TLSGTQAGAILATLVFIPVss 189
Cdd:PRK10406 109 VIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFqyvTLIGGQLLALLVVVVLQQT-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 190 LPEDQLLSWGWRIPFLLSALVLLVAYLVRRTMPETPVFE--DIKDKAQvarfpvvtlLRDYWPDvLRVIVCALIATVSTM 267
Cdd:PRK10406 187 LEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQEtrALKEAGS---------LKGLWRN-RRAFIMVLGFTAAGS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 268 TAVFALGYATSKFGVARPTMLWAGVLGNVTA-----LLTQPLWALLADRIGRK-PVFIGGVLGcAVLVFPYFMLVTS-GN 340
Cdd:PRK10406 257 LCFYTFTTYMQKYLVNTAGMHANVASGIMTAalfvfMLIQPLIGALSDKIGRRtSMLCFGSLA-ALFTVPILSALQNvSS 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 504305614 341 TLAIFAAAMiLSGVIYAAPNAIWPSFYAEMFDARVRysgtAIGTQLGFLAA 391
Cdd:PRK10406 336 PYAAFGLVM-CALLIVSFYTSISGILKAEMFPAQVR----ALGVGLSYAVA 381
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-431 |
2.12e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 92.64 E-value: 2.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 23 PKRAALVSFVGSMLEYYDFFIYGTAAALIfPKVFfaNVDPSTATLLallsFGIGYIARPVGAVILGHFGDRIGRKTVLLF 102
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPL-AEEF--GLSAAQLGLL----FAIPVLVGALLRIPLGFLVDRFGPRRVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 103 TLVLMGGSTLAIGLLPDaktignaaPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATL 182
Cdd:COG2223 76 GLLLLGIGLLLLALAVS--------YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 183 VFIPVsslpedqLLSWGWRIPFLLSALVLL-VAYLVRRTMPETPVFEDIKDKAQVARFPVVTLLRDYWpdvLRVIVCALI 261
Cdd:COG2223 148 LAPLL-------IAAFGWRNAFLILGILLLvVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFW---LLSLLYFGT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 262 ATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVfpyFMLVTSGNT 341
Cdd:COG2223 218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL---LLLALALGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 342 LAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLV---GEGPNGWIPVAIFVAC 418
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdatGSYTAAFLVFAVLALV 374
|
410
....*....|...
gi 504305614 419 CCVISAASAATAR 431
Cdd:COG2223 375 ALVLTLLLYRRPR 387
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-431 |
4.54e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 91.08 E-value: 4.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 16 EAAPNKLPKRAALVSFVGSMLEYYDFFIYGTAAALIFPKVFFanvdpsTATLLALLsFGIGYIARPVGAVILGHFGDRIG 95
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGL------SAAQLGLL-ASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 96 RKTVLLFTLVLMGGSTLAIGLLPDaktignaaPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQA 175
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGFATS--------FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 176 GAILATLVFIPVsslpedqLLSWGWRIPFLLSALvllvaylvrrtmpetpvfedikdkaqvarFPVVTLLRDYWpdvLRV 255
Cdd:COG2271 146 GGALAPPLLGWL-------LAAFGWRAAFLILGL-----------------------------PGLLLALLRFW---LLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 256 IVCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGR--KPVFIGGVLGCAVLVFpyf 333
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALL--- 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 334 mLVTSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLVGEGpnGWIPVA 413
Cdd:COG2271 264 -LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT--GYQAAF 340
|
410
....*....|....*...
gi 504305614 414 IFVACCCVISAASAATAR 431
Cdd:COG2271 341 LLLAALALLAALLALLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-391 |
6.66e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 87.34 E-value: 6.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 17 AAPNKLPKRAALVSFVGSMLEYYDFFIYGTAAALIFPKVffaNVDPSTATLLallsFGIGYIARPVGAVILGHFGDRIGR 96
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL---GASPAQAGLV----VTAYLLGAALGAPLAGRLADRFGR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 97 KTVLLFTLVLMGGSTLAIGLLPDaktignaaPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAG 176
Cdd:COG2814 75 RRVLLLGLLLFALGSLLCALAPS--------LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 177 AILATLVFIPVSSLpedqllsWGWRIPFLLSALVLL-VAYLVRRTMPETPVFEDIKDKAQVARFPVVTLLRdywpdvLRV 255
Cdd:COG2814 147 PALGPLLGGLLADL-------FGWRWVFLVNAVLALlALLLLLRLLPESRPAARARLRGSLRELLRRPRLL------LLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 256 IVCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLvfpyFML 335
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG----LLL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 504305614 336 VTSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAA 391
Cdd:COG2814 290 LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
26-421 |
7.03e-18 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 85.40 E-value: 7.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 26 AALVSFVGSMLEYYDFFIYGTAAALI-FPKVFFANV---DPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLL 101
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLTLIdFFKNFGLSKsvsSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 102 FTLVLMggstlAIGLLPDAKTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILAT 181
Cdd:pfam00083 81 IANVLF-----VIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 182 LVFIPVSSLPEdqllSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAQVAR----------------------- 238
Cdd:pfam00083 156 IFGLGLNKTSN----SDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEARevlaklrgvpdvdreldeikdsl 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 239 -------FPVVTLLRDYWPDVLRVIVCALIATVSTMTAVFAL-GYATSKFGVA--RPTMLWAGVLGNVTALLTqPLWALL 308
Cdd:pfam00083 232 eagqeaeKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIfYYSTTIFENLglSDSFLVTIIVGVVNFVFT-FIAIFL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 309 ADRIGRKPVFIGGVLGCAVLVFPY----FMLVTSGNTLAIFAAAMILSGV-IYAAPNAIWPSFY-AEMFDARVRYSGTAI 382
Cdd:pfam00083 311 VDRFGRRPLLLLGAAGMAICFVILgivaLLGVSKSDWAGIVAIVFIALFIaFFAMGWGPVPWVIvSELFPLSVRSKAMAL 390
|
410 420 430
....*....|....*....|....*....|....*....
gi 504305614 383 GTQLGFLAAGFTPLVSASLVGEGPNGWIPvAIFVACCCV 421
Cdd:pfam00083 391 ATAANWLANFLIGFLFPIITDAIGLGYTF-FIFAGLLVL 428
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-336 |
1.12e-16 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 80.24 E-value: 1.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 13 SSAEAAPNKLPKRAALVSFVGSMLEYYDFFIYGTAAALIFpkvffANVDPSTATLLALLSfgIGYIARPVGAVILGHFGD 92
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIA-----ADLGASSAQLGWIVS--AYLLGRAIGLLLFGRLGD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 93 RIGRKTVLLFTLVLMGGSTLAIGLLPDaktignaaPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSG 172
Cdd:COG0477 75 RYGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 173 TQAGAILATLVFIPVSSLpedqllsWGWRIPFLLSALVLLVAYLVRRTMPETpvfedikdKAQVARFPVVTLLRDYWPDV 252
Cdd:COG0477 147 IGLGLALGPLLGGLLVAA-------LGWRWIFLINAPLGLLALVLRLRLPES--------RGLLLALLALALAALLLAAL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 253 LRVIVCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPY 332
Cdd:COG0477 212 ALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
....
gi 504305614 333 FMLV 336
Cdd:COG0477 292 ALLL 295
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
30-402 |
1.74e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 77.73 E-value: 1.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 30 SFVGSMLEYYDFFIYGTAAALIFPKVffaNVDPSTATLLALLSFgigyIARPVGAVILGHFGDRIGRKTVLLFTLVLMGG 109
Cdd:cd17371 4 AFLGWALDGFDLLLLGLVLPALIAEF---GLDEAEAGLLGTVTL----AGGAIGGILGGILADRFGRVRVLVITILLFAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 110 STLAIGLlpdAKTIGNAApviltLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLVFIPVSS 189
Cdd:cd17371 77 FTLLCGF---AQNYWQLL-----ILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 190 LPEDQllsWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAQVARFPVvTLLRDYWPDVLRV-IVCALIATVSTMT 268
Cdd:cd17371 149 LLPPE---IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRP-SLRELFSPPLLRTtLLASLLATGALGG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 269 AVFAL----GYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMLVTsgnTLAI 344
Cdd:cd17371 225 YYGITtwlpSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPL---SPTL 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 504305614 345 FAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLV 402
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLA 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
60-446 |
1.41e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.08 E-value: 1.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 60 VDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIG-RKTVLLFTLVLMGGSTLAIGLLPDAKTIGNAAPVILTLLRLLQ 138
Cdd:COG2211 43 LSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 139 GLSAAgeQSGANSLTLEHSANSN-RAFFTSWTLSGTQAGAILATLVFIP-VSSLPEDQllSWGWRIPFLLSALVLLVAYL 216
Cdd:COG2211 123 AYTLV--NIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPlVAAFGGDA--ALGYRLTALIFAVLGLLAFL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 217 V-RRTMPETPVFEDIKDKaqvarfpvvtlLRDYWPDVLR-------VIVCALIATVSTMTAVFALGYATSKFGVARPTML 288
Cdd:COG2211 199 LtFFGTKERPVPEEEKVS-----------LKESLKALLKnrpflllLLAYLLFFLALALVAALLLYYFKYVLGLSAALVG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 289 WAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMLvtSGNTLAIFAAAMILSGVIYAAPNAIWPSFYA 368
Cdd:COG2211 268 LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL--GPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 369 EMFDA-----RVRYSGTAIG-----TQLGFLAAGFTPLVSASLVGEGPNGWIP-------VAIFVACCCVISAASAATA- 430
Cdd:COG2211 346 DVVDYdewktGRRREGLYFGiftfaIKLGQALAGALAGLLLALFGYVAGAAQSpsaltgiRLLFFLLPAVLLLLAALLLl 425
|
410 420
....*....|....*....|.
gi 504305614 431 -----RETHNVDIADLGKQRA 446
Cdd:COG2211 426 fypltRERHAEIRAELAARRA 446
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-395 |
6.26e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.59 E-value: 6.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 31 FVGSMLEYYDFFIYGTAAALIFPKVFfaNVDPSTATLLALLsFGIGYIarpVGAVILGHFGDRIGRKTVLLFTLVLMGGS 110
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL--GISPTEIGLLLTL-FSLGYA---LAQPLAGRLSDRFGRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 111 TLAIGLLPDAKTIgnaapvilTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLVFIPVSSl 190
Cdd:pfam07690 76 LLLLLFASSLWLL--------LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 191 pedqllSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAQVARFPVVTLLRDYWPDVLRVIVCALIATVSTMTAV 270
Cdd:pfam07690 147 ------LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 271 FALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMLVTSGNTLaIFAAAMI 350
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSL-WLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 504305614 351 LSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTP 395
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-402 |
7.18e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 63.53 E-value: 7.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 17 AAPNKLPKRAALVSFVGSMLEYYDFFIYGTAAALIFpkvffANVDPSTATLLALLSFGIGYIArpVGAVILGHFGDRIGR 96
Cdd:TIGR00895 9 QPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAIS-----AEWGLDPVQLGFLFSAGLIGMA--FGALFFGPLADRIGR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 97 KTVLLFTLVLMGGSTLAIGLLPDAKTIGnaapviltLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAG 176
Cdd:TIGR00895 82 RRVLLWSILLFSVFTLLCALATNVTQLL--------ILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 177 AILATL---VFIPVsslpedqllsWGWRIPFLLSALV-LLVAYLVRRTMPETPVFEDIKDKAQVARFPVVTLLRDYWP-- 250
Cdd:TIGR00895 154 AAVGGFlagWLIPV----------FGWRSLFYVGGIApLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEaq 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 251 ----------DVLRVIVCALIA-TVSTMTAVFALGYATSKFGVARPT----------------MLWAGVLGNVTALLTQP 303
Cdd:TIGR00895 224 salpeqkstqGTKRSVFKALFQgKTARITVLLWLLYFMLLVGVYFLTnwlpklmvelgfslslAATGGALFNFGGVIGSI 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 304 LWALLADRIGRKPVFIGGVLGCAVLVFPYFMLvtsgNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIG 383
Cdd:TIGR00895 304 IFGWLADRLGPRVTALLLLLGAVFAVLVGSTL----FSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWA 379
|
410
....*....|....*....
gi 504305614 384 TQLGFLAAGFTPLVSASLV 402
Cdd:TIGR00895 380 IGIGRLGAIIGPILAGYLL 398
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
73-424 |
2.08e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.21 E-value: 2.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 73 FGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVLMGGSTLAIGLLPDaktignaaPVILTLLRLLQGLSAAGEQSGANSL 152
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--------YWQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 153 TLEHSANSNRAFFTSWTLSGTQAGAILATLVFIPVSSLpedqllsWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKD 232
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA-------LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 233 KAQVARFPVVTLLRDYWPDVLRVIVCALIATVStMTAVFALG--YATSKFGVARPTMLWAGVLGNVTALLTQPLWALLAD 310
Cdd:cd17325 182 AVSAARLRSGLRLLLRDRRLLALFLAIFVLAFA-FGALEPFLplYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 311 RIGRKPVFIGGVLGCAVLVFpyfmLVTSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRysGTAIGTQLGFLA 390
Cdd:cd17325 261 RIGRKPLILIGLLLSAVALL----LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGR--GTAMGLFNTAFS 334
|
330 340 350
....*....|....*....|....*....|....*...
gi 504305614 391 AGFT--PLVSASLVGEG--PNGWIPVAIFVACCCVISA 424
Cdd:cd17325 335 LGMVlgPLLGGFLYDAFgfATPFLAAAALLLLAAVLFL 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
38-423 |
3.96e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 61.29 E-value: 3.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 38 YYDFFIYGTAAALIFPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVLMGGSTLAIGLL 117
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 118 PDaktignaaPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLVFIPVSSlpedqLLS 197
Cdd:cd06174 82 PS--------FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS-----SLG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 198 WGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAQVARFPVVTLLRDYWPD---VLRVIVCALIATVSTMTAVFALG 274
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNpglWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 275 YATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADR-IGRKPVFIGGVLGCAVLVFPYFMLVtsgnTLAIFAAAMILSG 353
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAP----SLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504305614 354 VIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLVGEG---PNGWIPVAIFVACCCVIS 423
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfglTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
63-425 |
1.53e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.48 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 63 STATLLALLSF-GIGYIarpVGAVILGHFGDRIGRKTVLLFTLVLMGGSTLAIGLLpdaktignAAPVILTLLRLLQGLS 141
Cdd:cd17475 29 SLAQVGLLLSAlNLGVA---VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV--------GSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 142 AAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLVFIPVSslpedqlLSWGWRIPFLLS-ALVLLVAYLVRRT 220
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLA-------LHYGWRAAFVVAgLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 221 MPETPVFEDIKDKAQVARFPVVTLLRDywPDVLRV-IVCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTAL 299
Cdd:cd17475 171 YREPPAASAATESASTLLRSLKEVLRN--RDVWLIaIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 300 LTQPLWALLADRI--GRKPVFIGGVLGCAVLVFPYFMLVTSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMfdARVRY 377
Cdd:cd17475 249 LGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAES--AGPEQ 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 504305614 378 SGTAIGTQ--LGFLAAGFTPLVSASLVgEGPNGWIPVAIFVACCCVISAA 425
Cdd:cd17475 327 AGTALGLAntINFIGIAIGPPLFGLLV-DATHSYAPAWLALALLLVLAAL 375
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
23-403 |
1.87e-07 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 53.01 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 23 PKRAALVS-FVGSMLEYYDFFiygtaaaLIFPKVFFANVDPSTATLLALLSFGIGYIARPVGAVILGHFGDRIGRKTVLL 101
Cdd:PRK12307 15 PQKNALFSaWLGYVFDGFDFM-------LIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 102 FTLVL----MGGSTLAIGLlpdaktignaapVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGA 177
Cdd:PRK12307 88 WSIVAysvgTGLSGLASGV------------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 178 ILATLvFIPvsSLPEdqllSWGWRIPFLLSALVLLVAYLVRRTMPETPVFED--IKDKAQVARFP----VVTLLRDYWPD 251
Cdd:PRK12307 156 IIAAY-FMP--SFAE----AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEakLSGKGKHSQSAwsvfSLSMKGLFNRA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 252 VLRVIVCALIATVSTMTA---VFAL--------GYATskfgVARPTMLWAGVLGNVTALLtqpLWALLADRIGRKPVFIG 320
Cdd:PRK12307 229 QFPLTLCVFIVLFSIFGAnwpIFGLlptylageGFDT----GVVSNLMTAAAFGTVLGNI---VWGLCADRIGLKKTFSI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 321 GVLGCAVLVFPYFMLVTSGNTLaifaAAMILSGVIYA--APNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVS 398
Cdd:PRK12307 302 GLLMSFLFIFPLFRIPQDNYLL----LGACLFGLMATnvGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAA 377
|
....*
gi 504305614 399 ASLVG 403
Cdd:PRK12307 378 TWLGI 382
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
28-430 |
2.75e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.20 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 28 LVSFVGSMLEYYDFFIYGTAAALIFPKVffaNVDPSTATLLallsFGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVLM 107
Cdd:cd17365 2 ALCFLIIVLDGFDLAVMGFVAPALAQDW---GLSPAQLGPV----GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 108 GGSTLAIGLLPDAKT-----------IGNAAPViltllrllqglsaageqsgANSLTLEHSANSNRAFFTSWTLSGTQAG 176
Cdd:cd17365 75 GLFTLLTAFAQSVLQlallrfltglgLGAAMPN-------------------AITLVSEYAPARRRSLAVTLMFCGYPLG 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 177 AILATLVFIPVsslpedqLLSWGWRIPFLLSALVLLVaylvrrtmpetpvfedikdkaqVARFPVVTLLrdywpdvlrVI 256
Cdd:cd17365 136 AALGGFLAAAL-------IPAFGWRSVFLLGGVPPLI----------------------LLPLLRGTLL---------LW 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 257 VCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVfpyFMLV 336
Cdd:cd17365 178 VTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSL---ALLG 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 337 TSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLVGegpNGWIPVAIFV 416
Cdd:cd17365 255 VSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLA---AGLGPESVFL 331
|
410
....*....|....
gi 504305614 417 ACCCVISAASAATA 430
Cdd:cd17365 332 ALAIPAALGALAVL 345
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
28-424 |
5.33e-07 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 51.51 E-value: 5.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 28 LVSFVGSMLEYYDFFIYGTAAaLIFPKVFFANVDPSTATLLALLSfGIGYIARPVGAVILGHFGDRIGRKTVLLFTLVLM 107
Cdd:cd17364 2 IIAGMGFFTDAYDLFSISLVT-KILGRLYYGGKGSLPSGVSGLVN-AAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 108 GGSTLAIGLLPDakTIGNAAPVILTLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLVFIPV 187
Cdd:cd17364 80 IIGTILSALSPG--STPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 188 SSLPEDQL-------LSWGWRIPFLLSALVLLVAYLVRRTMPETPVFEDIKDKAqvarFPVVTLlrdYWPDVLRVIvcal 260
Cdd:cd17364 158 SAIFEHPLpagtyhhADLVWRIVLGLGAIPALSVLYFRKHLLGTAGTWFLLDIA----FYGQNL---FQSTIISAI---- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 261 iaTVSTMTAVFALGYATSKFGvarptmlwaGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVF----PYFMLV 336
Cdd:cd17364 227 --GFSKTMNAYQELFNIAVGQ---------LIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLilagPYDHWK 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 337 TS-GNTLAIFAAAMILSGviyAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLVGegpNGWIPVAIF 415
Cdd:cd17364 296 IStIGFFVLYGLTFFFSN---FGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQ---NIGVRNVLI 369
|
410
....*....|
gi 504305614 416 VAC-CCVISA 424
Cdd:cd17364 370 ILAgVALLGI 379
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
82-361 |
5.44e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 5.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 82 VGAVILGHFGDRIGRKTVLLFTLVLMGGSTLAIGLLPDAKT--IGNAAPVILTLLRLLQGLSAAGEQSGANSltlehsan 159
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALllLARALAGLAHGGFWAIAAAYAADLVPPEK-------- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 160 snRAFFTSWTLSGTQAGAILAtlvfIPVSSLPEDqllSWGWRIPFLLS-ALVLLVAYLVRRTMPETPVFEDIKDKaqvAR 238
Cdd:cd17324 121 --RGRAIGLVFSGLTLGLVLG----RPLGGLLGQ---LLGWRAAFLAIaVLALLAALLLWRLLPSLPPKKPGSLG---LL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 239 FPVVTLLRDywpdvlRVIVCALIATVSTMTAVFAL-----GYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIG 313
Cdd:cd17324 189 SSLLLLLRN------PRLRLAYLITFLLFGGFFALytylaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGG 262
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 504305614 314 RKPVFIGGVLGCAVLVfpyFMLVTSGNTLAIFAAAMILSGVIYAAPNA 361
Cdd:cd17324 263 RRALLIALLLLAAALL---LLTLLGPSPLLLLVGLVLWGLGFFAAHSA 307
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
25-223 |
1.37e-06 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 50.47 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 25 RAALVSFVGSMLEYYDFFIYgtaaALIFPKVFfANVDPSTATLLALLSfgIGYIARPVGAVILGHFGDRIGRKTVLLFTL 104
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLI----TLVLTEVQ-GEFGLTTVQAASLIS--AAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 105 VLMGGSTLAIGLLPDAKTIGNAAPVIltllrllqGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLSGTQAGAILATLVF 184
Cdd:PRK03893 93 VLFSVGTLACGFAPGYWTLFIARLVI--------GMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVY 164
|
170 180 190
....*....|....*....|....*....|....*....
gi 504305614 185 IPVSSLpedqllsWGWRIPFLLSALVLLVAYLVRRTMPE 223
Cdd:PRK03893 165 SLVVPV-------WGWRALFFIGILPIIFALWLRKNLPE 196
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
256-425 |
2.89e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.95 E-value: 2.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 256 IVCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFPYFMl 335
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 336 vtsGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLVGEGpnGWIPVAIF 415
Cdd:pfam07690 82 ---ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFLI 156
|
170
....*....|
gi 504305614 416 VACCCVISAA 425
Cdd:pfam07690 157 LAILSLLAAV 166
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
256-409 |
1.34e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 47.24 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 256 IVCALIATVSTM---TAVFALGYATSKFGvARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGG----VLGCAVL 328
Cdd:cd06179 1 AALCLAYFAQLFgvtLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGnllgVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 329 VFpyfmlVTSGNTLaifAAAMILSGvIYAAPNAIWPSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLVGEGPNG 408
Cdd:cd06179 80 GT-----AKSVNML---IGGQALIG-IGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAG 150
|
.
gi 504305614 409 W 409
Cdd:cd06179 151 W 151
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
256-427 |
1.85e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.83 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 256 IVCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIggvLGCAVLVFPYFML 335
Cdd:cd17353 220 LMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLS---IAFLIQGVAMFLL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 336 VTSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFdaRVRYSGTAIG-TQLGFLAAGFT-PLVSASLVGEGpnGWIPVA 413
Cdd:cd17353 297 PFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFF--GTKNAGTNYGlLYTAKGVGGLIgPIIAAYVLYTG--GYNAAF 372
|
170
....*....|....
gi 504305614 414 IFVACCCVISAASA 427
Cdd:cd17353 373 IIAAALSLVALALA 386
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
172-373 |
3.90e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 45.76 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 172 GTQAGAILATLVFIPVSSLPEDQLLSWGWRIPFLL-SALVLLVAYLVRRTMPETPVFEDIKDKAQVARFPVVT-LLRDyw 249
Cdd:pfam13347 146 GGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVlMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKeVFRN-- 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 250 PDVLRVIVCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVL- 328
Cdd:pfam13347 224 RAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGf 303
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 504305614 329 VFPYFMlvtSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDA 373
Cdd:pfam13347 304 ALALLL---GPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDY 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
289-425 |
4.37e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.50 E-value: 4.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 289 WAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVLVFpyfmLVTSGNTLAIFAAAMILSGVIYAAPNAIWPSFYA 368
Cdd:cd06174 35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL----LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIA 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 504305614 369 EMFDARVRYSGTAIGTQLGFLAAGFTPLVSASLVGEGPNGWIPVAIFVACCCVISAA 425
Cdd:cd06174 111 DLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAI 167
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
255-416 |
3.18e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.57 E-value: 3.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 255 VIVCALIATVSTMTAVFALGYATSKFGVARPTMLWAGVLGNVTALLTQPLWALLADRIGRKPVFIGGVLGCAVlvfPYFM 334
Cdd:cd17330 4 VVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAV---SYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 335 LVTSGNTLAIFAAAMILSgvIYAAPNAIWPSFYAEMFDarVRYSGTAIGTQLGFLAAGFT--PLVSASLVGEGPNGWIPV 412
Cdd:cd17330 81 LGLSRNLWLLFLARFLDG--LTGGNVSVAQAYIADITD--EEERAKAFGIISAAFGLGFIlgPALGGFLSTPYGYALPFL 156
|
....
gi 504305614 413 AIFV 416
Cdd:cd17330 157 VAAA 160
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
299-393 |
1.14e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 39.17 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 299 LLTQPLWALLADRIGRKPVFIGGVLGCAVLvfpYFMLVTSGNtLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRys 378
Cdd:TIGR00880 12 LIYSPLSGLLTDRFGRKPVLLVGLFIFVLS---TAMFALSSN-ITVLIIARFLQGFGAAFALVAGAALIADIYPPEER-- 85
|
90
....*....|....*
gi 504305614 379 GTAIGTQLGFLAAGF 393
Cdd:TIGR00880 86 GVALGLMSAGIALGP 100
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
82-428 |
2.89e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 82 VGAVILGHFGDRIGRKTVLLFTLVLMGGSTLAIGLLPDAKTIgnaapvilTLLRLLQGLSAAGEQSGANSLTLEHSANSN 161
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL--------LASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 162 RAFFTSWTLSGTQAGAIlatlVFIPVSSLpedqLLSWGWRIPFLLSALVLLVAYLVRRTMPETPvfediKDKAQVARFPV 241
Cdd:cd17473 122 RAKMLGLQSAAMSLGGV----VFLLLGGA----LAEIGWRAPFLVYLLALPVLILVLLFLPEPA-----RKSKSAASPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 242 VTLLRDYWPDVLRVIVCALIATVSTMTAVFALGYATSKFGVARPTML-WAGVLGNVTALLTQPLWALLADRIGRKPVFIG 320
Cdd:cd17473 189 ATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKRRLGKRRLLAI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 321 GVLGCAVlvfpYFMLVTSGNTLAIFAAAMILSGVIY--AAPNAIwpSFYAEMFDARVRYSGTAIGTQLGFLAAGFTPLVS 398
Cdd:cd17473 269 GFALMAL----GFLLLALASGLWVVLLGAILAGLGFglLLPTLN--SWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVL 342
|
330 340 350
....*....|....*....|....*....|
gi 504305614 399 ASLVGEGPNGWIPVAIFVACCCVISAASAA 428
Cdd:cd17473 343 GPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
82-119 |
6.52e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.33 E-value: 6.52e-03
10 20 30
....*....|....*....|....*....|....*...
gi 504305614 82 VGAVILGHFGDRIGRKTVLLFTLVLMGGSTLAIGLLPD 119
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPS 77
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
150-369 |
6.59e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 6.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 150 NSLTLEHSANSN-RAFFTSWTLSGTQAGAILATLVFIPVSSL--PEDQLLSWGWRIPFLLSALVLLVAYLVRRTMPETPV 226
Cdd:cd17332 121 TALIPELTDDPEeRTSLTSWRMFFATIGGLLVTVLPPPLVAYfgGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVP 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 227 FEDIKDKAQVARFPVVTLLRDYWPDVLRVIVCALIATVSTMTAVFalgYATSKFGVARPTMLWAGVLGNVTALLTQPLWA 306
Cdd:cd17332 201 PEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLV---YYFKYVLGGRAELVLLLLLILSGALLALLPWP 277
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504305614 307 LLADRIGRKPVFIGGvLGCAVLVFPYFMLVTSGNTLAIFAAAmILSGVIYAAPNAIWPSFYAE 369
Cdd:cd17332 278 PLKKRFGKKKAFFIG-LLLAILGLLLLFFLPPGNLVLILVLA-VLAGIGYGGANLLPWAMLAD 338
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
304-429 |
6.78e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.32 E-value: 6.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 304 LWALLADRIG----RKPVFIGGVLGCAVLVFPYFMlvtsgNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRYSG 379
Cdd:cd17319 234 LGGRLSDRLLrgarRLVIIIGLLLAAVGLLLAYLT-----TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATA 308
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 504305614 380 TAIGTQLGFLAAGFTPLVSASLVGEGpNGWIPVAIFVACCCVISAASAAT 429
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDAT-GSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
255-402 |
9.05e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 38.33 E-value: 9.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 255 VIVCALIATVSTMT-AVF--ALGYATSKFGVARPTMLwAGVLGNVTALLTQPL-WALLADRIGRKPVFIGGVLGCAVLVF 330
Cdd:cd17323 1 VFIISFLTFVVTFGsSIYspALPQIAEDFHVSEEVAN-LGVSLFVLGFGLGPLiWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504305614 331 PyfmlVTSGNTLAIFAAAMILSGVIYAAPNAIWPSFYAEMFDARVRysGTAIG--TQLGFLAAGFTPLVSASLV 402
Cdd:cd17323 80 G----CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEER--GKAMGvySLGPLLGPALGPIIGGFIT 147
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
25-420 |
9.66e-03 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 38.17 E-value: 9.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 25 RAALVSFVGSMLEYYDFFIYgTAAALIFPKVFFANVDPSTATLLALLSfGIGYIARPVGAVILGHFGDRIGRKTVLLFTL 104
Cdd:TIGR00887 16 RAIVIAGVGFFTDSYDLFCI-SLVTKMLGYVYYHGKGPLPSSVSAAVN-GSASIGTLAGQLFFGWLADKLGRKRVYGMEL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 105 VLMGGSTLAIGLLPDAKTIGNAAPVIltLLRLLQGLSAAGEQSGANSLTLEHSANSNRAFFTSWTLS----GTQAGAILA 180
Cdd:TIGR00887 94 IIMIIATVASGLSPGSSPKSVMATLC--FWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAmqgfGILAGAIVA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 181 ---TLVFIPVSSLPEDQLLSWG---------WRIPFLLSALVLLVAYLVRRTMPETPVFE-DIKDKAQVA---------- 237
Cdd:TIGR00887 172 livLAGFKHSLEAAADEASCTGscvpavdymWRILIGFGAVPALLALYFRLTIPETPRYTaDVAKDVEQAasdmsavlqv 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 238 -----------RFPVVTLLRDYWPDVLR---------------VIVCAL-IA--TVSTMTAVF--ALGYATSKFGVARPT 286
Cdd:TIGR00887 252 kieaepdevekASTAVEVPKASWSDFFThffkwrhgkhllgtaGSWFLLdIAfyGVNLNQKVIlsAIGYSPPAATNNAYE 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504305614 287 MLWAGVLGNVTALL--TQP-LW--ALLADRIGRKPV-----FIGGVLGCaVLVFPYFMLVTSGnTLAIFAAAMILSGViy 356
Cdd:TIGR00887 332 ELYKTAVGNLIIALagTVPgYWvtVFLVDIIGRKPIqlmgfFILTVLFF-VLGFAYNHLSTHG-FLAIYVLAQFFANF-- 407
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504305614 357 aAPNA---IWPsfyAEMFDARVRYSGTAIGTQLGFLAA-----GFTPLV--SASLVGEGPNGWIPVAIFVACCC 420
Cdd:TIGR00887 408 -GPNAttfIVP---GEVFPTRYRSTAHGISAASGKAGAiigqfGFLYLAqhGDPTKGYPTGIWMGHVLEIFALF 477
|
|
| |
