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Conserved domains on  [gi|504127168|ref|WP_014360502|]
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HNH endonuclease family protein [Gordonia polyisoprenivorans]

Protein Classification

HNH endonuclease family protein( domain architecture ID 10539890)

HNH endonuclease family protein-containing a DUF1524 domain with a conserved HXXP motif, may function as an endonuclease

PubMed:  32807610

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1524 pfam07510
Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a ...
 77-217 1.60e-17

Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.


:

Pssm-ID: 462188 [Multi-domain]  Cd Length: 141  Bit Score: 75.96  E-value: 1.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504127168   77 DTRNDILMRDLSDVTVGSVRS-CPTAVLTGEFRSPYTGATVVFRRDRSAIGVQIDHIVPLSLSWDLGAWSWPAQRRVEFA 155
Cdd:pfam07510   1 DPRDDEFRRDLTDKVFYRGGSrCLRYILAGRLESDLYENDEIDGSSKIIFDRQIEHILPQNPAWGWGAGQWDEEQREIYV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504127168  156 NDPANLVAVDAASNQAKSDGEpavWMPPLRAF--HCRYSIQFVAVADTYRLAVDAASRQVLTDV 217
Cdd:pfam07510  81 NDLGNLTLLTGSLNSAASNKD---FLPKRKAYekSCLYLTRQLAVKDKWNEEVIEARQEALAKV 141
 
Name Accession Description Interval E-value
DUF1524 pfam07510
Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a ...
 77-217 1.60e-17

Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.


Pssm-ID: 462188 [Multi-domain]  Cd Length: 141  Bit Score: 75.96  E-value: 1.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504127168   77 DTRNDILMRDLSDVTVGSVRS-CPTAVLTGEFRSPYTGATVVFRRDRSAIGVQIDHIVPLSLSWDLGAWSWPAQRRVEFA 155
Cdd:pfam07510   1 DPRDDEFRRDLTDKVFYRGGSrCLRYILAGRLESDLYENDEIDGSSKIIFDRQIEHILPQNPAWGWGAGQWDEEQREIYV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504127168  156 NDPANLVAVDAASNQAKSDGEpavWMPPLRAF--HCRYSIQFVAVADTYRLAVDAASRQVLTDV 217
Cdd:pfam07510  81 NDLGNLTLLTGSLNSAASNKD---FLPKRKAYekSCLYLTRQLAVKDKWNEEVIEARQEALAKV 141
Cas9 COG3513
CRISPR-Cas system type-II protein Cas9 [Defense mechanisms]; CRISPR-Cas system type-II protein ...
 108-181 4.82e-06

CRISPR-Cas system type-II protein Cas9 [Defense mechanisms]; CRISPR-Cas system type-II protein Cas9 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442735 [Multi-domain]  Cd Length: 812  Bit Score: 46.88  E-value: 4.82e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504127168 108 RSPYTGATVVFRrDRSAIGVQIDHIVPLSLSWDlgawswpaqrrvefaNDPANLVAVDAASNQAKSDGEPAVWM 181
Cdd:COG3513  542 RCPYTGKPISIS-DLLDGSVEIDHILPRSRTLD---------------DSFNNKVLCLADANREKGNRTPYEAL 599
cas_Csn1 TIGR01865
CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile ...
 108-180 5.75e-05

CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.


Pssm-ID: 273840  Cd Length: 805  Bit Score: 43.57  E-value: 5.75e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504127168  108 RSPYTGATVVFRRDRSAIGVQIDHIVPLSLSWDlgawswpaqrrvefaNDPANLVAVDAASNQAKSDGEPAVW 180
Cdd:TIGR01865 583 KCMYTGKEIDIDDLFDLSYYEIDHILPQSRSFD---------------DSISNKVLVLASENQEKGDQTPYEA 640
Csn1 cd09643
CRISPR/Cas system-associated protein Cas9; CRISPR (Clustered Regularly Interspaced Short ...
 108-180 5.82e-05

CRISPR/Cas system-associated protein Cas9; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II


Pssm-ID: 187774 [Multi-domain]  Cd Length: 799  Bit Score: 43.56  E-value: 5.82e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504127168 108 RSPYTGATVVFRRDRSAIGVQIDHIVPLSLSWDlgawswpaqrrvefaNDPANLVAVDAASNQAKSDGEPAVW 180
Cdd:cd09643  579 KCMYTGKEIDIDDLFDLSYYEIDHILPQSRSFD---------------DSISNKVLVLASENQEKGDQTPYEE 636
 
Name Accession Description Interval E-value
DUF1524 pfam07510
Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a ...
 77-217 1.60e-17

Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.


Pssm-ID: 462188 [Multi-domain]  Cd Length: 141  Bit Score: 75.96  E-value: 1.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504127168   77 DTRNDILMRDLSDVTVGSVRS-CPTAVLTGEFRSPYTGATVVFRRDRSAIGVQIDHIVPLSLSWDLGAWSWPAQRRVEFA 155
Cdd:pfam07510   1 DPRDDEFRRDLTDKVFYRGGSrCLRYILAGRLESDLYENDEIDGSSKIIFDRQIEHILPQNPAWGWGAGQWDEEQREIYV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504127168  156 NDPANLVAVDAASNQAKSDGEpavWMPPLRAF--HCRYSIQFVAVADTYRLAVDAASRQVLTDV 217
Cdd:pfam07510  81 NDLGNLTLLTGSLNSAASNKD---FLPKRKAYekSCLYLTRQLAVKDKWNEEVIEARQEALAKV 141
Cas9 COG3513
CRISPR-Cas system type-II protein Cas9 [Defense mechanisms]; CRISPR-Cas system type-II protein ...
 108-181 4.82e-06

CRISPR-Cas system type-II protein Cas9 [Defense mechanisms]; CRISPR-Cas system type-II protein Cas9 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442735 [Multi-domain]  Cd Length: 812  Bit Score: 46.88  E-value: 4.82e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504127168 108 RSPYTGATVVFRrDRSAIGVQIDHIVPLSLSWDlgawswpaqrrvefaNDPANLVAVDAASNQAKSDGEPAVWM 181
Cdd:COG3513  542 RCPYTGKPISIS-DLLDGSVEIDHILPRSRTLD---------------DSFNNKVLCLADANREKGNRTPYEAL 599
HNH_4 pfam13395
HNH endonuclease; This HNH nuclease domain is found in CRISPR-related proteins.
 110-174 8.17e-06

HNH endonuclease; This HNH nuclease domain is found in CRISPR-related proteins.


Pssm-ID: 433172 [Multi-domain]  Cd Length: 55  Bit Score: 41.84  E-value: 8.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504127168  110 PYTGATVVFRRDRSAIGVQIDHIVPLSLSWDlgawswpaqrrvefaNDPANLVAVDAASNQAKSD 174
Cdd:pfam13395   2 PYTGEQISIDDLFSEKNYDIDHILPYSRSFD---------------DSFSNKVLVLRSANQEKGN 51
cas_Csn1 TIGR01865
CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile ...
 108-180 5.75e-05

CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.


Pssm-ID: 273840  Cd Length: 805  Bit Score: 43.57  E-value: 5.75e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504127168  108 RSPYTGATVVFRRDRSAIGVQIDHIVPLSLSWDlgawswpaqrrvefaNDPANLVAVDAASNQAKSDGEPAVW 180
Cdd:TIGR01865 583 KCMYTGKEIDIDDLFDLSYYEIDHILPQSRSFD---------------DSISNKVLVLASENQEKGDQTPYEA 640
Csn1 cd09643
CRISPR/Cas system-associated protein Cas9; CRISPR (Clustered Regularly Interspaced Short ...
 108-180 5.82e-05

CRISPR/Cas system-associated protein Cas9; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II


Pssm-ID: 187774 [Multi-domain]  Cd Length: 799  Bit Score: 43.56  E-value: 5.82e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504127168 108 RSPYTGATVVFRRDRSAIGVQIDHIVPLSLSWDlgawswpaqrrvefaNDPANLVAVDAASNQAKSDGEPAVW 180
Cdd:cd09643  579 KCMYTGKEIDIDDLFDLSYYEIDHILPQSRSFD---------------DSISNKVLVLASENQEKGDQTPYEE 636
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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