|
Name |
Accession |
Description |
Interval |
E-value |
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
4-531 |
3.31e-155 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 453.85 E-value: 3.31e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 4 RTSSYLKGASILVGAGILSRLLGVFFKIPLYQMVGSYGNGIYGNVTSIYNLLLMVSTVGFPVAISKMVSENVAKKEYATA 83
Cdd:COG5841 2 KKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYKGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 84 HRVFKISIAILVVLGTFSSLFLFFGAEWIIEVANWTAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQ 163
Cdd:COG5841 82 RRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGDPRAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPTAVSQVIEQ 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 164 LIRVFLGMLLCWVMVgQFGIGLGVGGAVFGATAGGLVAAILLSFLYHEFVTANKRLLKTRTRKRQRSNRELIKRLVIISI 243
Cdd:COG5841 162 IVRVIFILLLAYLLL-PYGLEYAAAGATFGAVIGALAGLLVLLYYYRKRKKKLKRLLEKSKTKSKESSKDILKELLRIAI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 244 PVTLTSALVAMFSTVDSFIYVSRLAVAGIDEITATMMFGDFT-NAETLITIPLVISGNLAVAMIPAISESFAKRDRKEMN 322
Cdd:COG5841 241 PITLSSLVLPLFQLIDSFTVPRRLQAAGLSASEATSLYGILSgMAQPLVNLPTVLATALATSLVPAISEAFAKKDRKLVR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 323 EKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFpGSPYGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAI 402
Cdd:COG5841 321 RRINQALRLTLLIGLPAAVGLAVLAEPINTLLF-GNPEGGGILAILAPSAIFLSLQQVTTGILQGLGKQKIPVINLLIGL 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 403 IIRFITGWIFlsIPFFNIQGIVISSVITFAFLTVANYLSVKRYTHVDVDFFHILIKPLFAAVIMGILVFYAYKGISAL-- 480
Cdd:COG5841 400 LVKIILNYLL--VPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLDLRRRLLKPLLASLIMGIVVLLLYRLLSLFlp 477
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 504123335 481 ---LGGFIGIALSLIIGVLVYSFVLILIRGITEKEIRVLPGSRT-LLTFYRRLNR 531
Cdd:COG5841 478 esrLGALLATLIAVLVGAIVYLLLLLKLGLITKEELRRLPKGGKkLARLLRKLKL 532
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
14-448 |
2.92e-124 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 371.42 E-value: 2.92e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 14 ILVGAGILSRLLGVFFKIPLYQMVGSYGNGIYGNVTSIYNLLLMVSTVGFPVAISKMVSENVAKKEYATAHRVFKISIAI 93
Cdd:cd13124 2 ILTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRVSLIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 94 LVVLGTFSSLFLFFGAEWIIEVANWTAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIRVFLGMLL 173
Cdd:cd13124 82 LLILGLVFFLLLFFGAPFLAQLLLGDPRLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVRVIVILVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 174 CWVMV-GQFGIGLGVGGAVFGATAGGLVAAILLSFLYHEFVTANKRLLKTRTRKRQrSNRELIKRLVIISIPVTLTSALV 252
Cdd:cd13124 162 AYLLLpVGGGLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKI-STKEILKELLSYAIPITLSSLIL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 253 AMFSTVDSFIYVSRLAVAGIDEITATMMFGDFT-NAETLITIPLVISGNLAVAMIPAISESFAKRDRKEMNEKIVLAIRV 331
Cdd:cd13124 241 PLLQLIDSFTVPRRLQAAGLSESEATALYGILTgRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 332 ILLIAFPSCIGLSVLSYGIFNLLFpGSPYGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRFITGWI 411
Cdd:cd13124 321 TLLIGLPAAVGLAVLAEPINTLLF-GDSEGGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYV 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 504123335 412 FlsIPFFNIQGIVISSVITFAFLTVANYLSVKRYTHV 448
Cdd:cd13124 400 L--IPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
|
|
| spore_V_B |
TIGR02900 |
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ... |
8-501 |
3.33e-61 |
|
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]
Pssm-ID: 274343 [Multi-domain] Cd Length: 488 Bit Score: 209.46 E-value: 3.33e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 8 YLKGASILVGAGILSRLLGVFFKIPLYQMVGSYGNGIYGNVTSIYNLLLMVSTVGFPVAISKMVSENVAKKEYATAHRVF 87
Cdd:TIGR02900 1 FLKGTFILTIANLITRILGFIFRIVLSRILGAEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKKIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 88 KISIAILVVLGTFSSLFLFFGAEWIIEVANWTAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIRV 167
Cdd:TIGR02900 81 KVSLIFTLIWSLIVTAIVFLLSPFIASTLLKDERSLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQVIEQIVRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 168 FLGMLLCWVMVGqFGIGLGVGGAVFGATAGGLVAAILLSFLYHEFVTANKRLLKTRTRKrqrSNRELIKRLVIISIPVTL 247
Cdd:TIGR02900 161 SVVALLISAFLP-YGLEYAVAGAYLSLVLGELVSLLYLYFFFKRKKSFSIRFPFFDYKS---EGKALLFDLFSVSLPLTL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 248 TSALVAMFSTVDSFIYVSRLAVAGIDEITATMMFGDFTN-AETLITIPLVISGNLAVAMIPAISESFAKRDRKEMNEKIV 326
Cdd:TIGR02900 237 SRFIGSLLYFLETLLVPQRLVIAGVTYREATSLYGKLSGmAMPLLTFPAVITSSLSTALVPDISEAMAKKNYSSIEKRIN 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 327 LAIRVILLIAFPSCIGLSVLSYGIFNLLFpGSPYGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRF 406
Cdd:TIGR02900 317 QAIKISLLLGLITTVILLVIPDELGALFY-GRPDAGNFIRVLAPSFPFLYFSAPLQSILQGLGKQKVALRNSLIGAIVKI 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 407 ITGWIFLSIPFFNIQGIVISSVITFAFLTVANYLSVKRYTHVDVDFFHILIKPLFAavIMGILVFYAYKGISALLGGFIG 486
Cdd:TIGR02900 396 ILLFVLTSIPSINIYGYAITFIITSVLVTILNLAEIKKNIRITIDLSDFLIFALLG--ILVYLGLSLLKYIIFNPNILIN 473
|
490
....*....|....*
gi 504123335 487 IALSLIIGVLVYSFV 501
Cdd:TIGR02900 474 LLLIIILGFSLYILL 488
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
8-443 |
1.12e-32 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 129.20 E-value: 1.12e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 8 YLKGASILVGAGILSRLLGVFFKIPLYQMVGSYGNGIYGNVTSIYNLLLMVSTVGFPVAISKMVSENVAKKeyatAHRVF 87
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYRKEK----IREII 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 88 KISIAILVVLGTFSSLFLFFGAEWIievANWTAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIRV 167
Cdd:cd13128 77 STSLVLKLILGILALLLLFLFAFLI---AFYDPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 168 FLGMLLCWvmvgqfgIGLGVGGAVFGATAGGLVAAILLSFLYHefvtankrlLKTRTRKRQRSNRELIKRLVIISIPVTL 247
Cdd:cd13128 154 ILALILVL-------LGGGLIGFALAYLIASVLSAILLLYIYR---------KKILLPKFFSFDLKLAKELLRFSIPLAL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 248 TSALVAMFSTVDSFIyvsrlavagIDEITATMMFGDFTNAETLITIPLVISGNLAVAMIPAISESFAKrDRKEMNEKIVL 327
Cdd:cd13128 218 SGIFSLIYTRIDTIM---------LGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKN-DKDELKKLLKK 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 328 AIRVILLIAFPSCIGLSVLSYGIFNLLF-PGSPYGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRF 406
Cdd:cd13128 288 SFKYLFLISLPIAIGLFLFAEPIITLLFgEEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNV 367
|
410 420 430
....*....|....*....|....*....|....*..
gi 504123335 407 ITGWIFlsIPFFNIQGIVISSVITFAFLTVANYLSVK 443
Cdd:cd13128 368 ILNLLL--IPKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
9-506 |
1.89e-22 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 100.61 E-value: 1.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 9 LKGASILVGAGILSRLLGVFFKIPLYQMVGSygngiyGNVTSIYN--------LLLMVSTVGFPVAISKMVSENVAKKEY 80
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGA------GAVADAFFvafripnlLRRLFAEGALSAAFVPVLAEALEKEGE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 81 ATAHRVFKISIAILVVLGTFSSLFLFFGAEWIIEV--ANWTAESYPALVAIA--LAP--LFISFVSAYRGFFQGFQIMTP 154
Cdd:COG0728 75 EEARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLlaPGFDPEKFALAVALTriMFPyiLFIGLSALLGGVLNARGRFAA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 155 TAISQIIEQLIRVFLGMLLCWVMvgqfgiGLGVGGAVFGATAGGLV-AAILLSFLYHefvtankrlLKTRTRKRQRSNRE 233
Cdd:COG0728 155 PALAPVLLNLVIIAGLLLLAPLF------GPGIYALAWGVLLGGVLqLLIQLPALRR---------LGLRLRPRFDLRDP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 234 LIKRLVIISIPVTLTSALVAMFSTVDSFIyVSRLAVAGIdeiTAtmmfgdFTNAETLITIPL-VISGNLAVAMIPAISES 312
Cdd:COG0728 220 GVRRVLKLMLPALLGVSVSQINLLVDTIL-ASFLPEGSV---SA------LYYADRLYQLPLgLFGVAIGTALLPRLSRA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 313 FAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFpgsPYGGF----------ILSTYSYATIFMMLSNTFQ 382
Cdd:COG0728 290 AAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLF---ERGAFtaedtaltalALAAYALGLPAFALVKVLA 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 383 SILQSIDRFRIPLINLGIAIIIRFITGWIFlsIPFFNIQGIVISSVITFAFLTVANYLSVKRYTH--VDVDFFHILIKPL 460
Cdd:COG0728 367 RAFYARQDTRTPVRIAVIAVVVNIVLNLLL--VPPLGHAGLALATSLSALVNALLLLVLLRRRLGglPLRGILRTLLKLL 444
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 504123335 461 FAAVIMGILVFYAYKGISALLGG-----FIGIALSLIIGVLVYSFVLILIR 506
Cdd:COG0728 445 LASLVMGAVLWLLLRLLGDWLGGgllgrLLALALLILVGAAVYFALLLLLG 495
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
9-313 |
9.90e-18 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 83.51 E-value: 9.90e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 9 LKGASILVGAGILSRLLGVFFKIPLYQMVGSYGNGIYGNVTSIYNLLLMVSTVGFPVAISKMVSENVAKKEyatahRVFK 88
Cdd:pfam01943 2 LKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYE-----LVSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 89 ISIAILVVLGTFSSLFLFfgAEWIIEVANWTAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIRVF 168
Cdd:pfam01943 77 YWLNALLVKLVLVLLFLL--LPLIAAFLGLPELAVLYRILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLSRVI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 169 LGMLLCWVMVGQFGIglgVGGAVFGATAGGLVAAILLSFLYH-EFVTANKRllktrtrkrqrsnreLIKRLVIISIPVTL 247
Cdd:pfam01943 155 LVFIAVFLPGDIVAA---LLYQVLAALVGGIIALAVLRKIFRpRFVFPSLK---------------LVRKLLSFGAPLFI 216
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504123335 248 TSALVAMFSTVDSFIYvSRLAVAGIdeitatmmFGDFTNAETLITIPL-VISGNLAVAMIPAISESF 313
Cdd:pfam01943 217 SSLAISLYTYIDSILL-GLLLGAGA--------VGIYNAAYQLLVAIQgLLNPIVTAVLFPVFSKLQ 274
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
6-439 |
1.59e-17 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 84.23 E-value: 1.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 6 SSYLKGASILVGAGILSRLLGVFFKIPLYQMVGSYGNGIYGNVTSIYNLLLMVSTVGFPVAISKMVSENVAKKeyatAHR 85
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEE----LRR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 86 VFKISIAILVVLGTFSSLFLFFGAEWIIEVANWtAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLI 165
Cdd:COG2244 78 LLSTALLLRLLLSLLLALLLLLLAPFIAALLGE-PELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 166 RVFLGMLLCWvmvgqfgIGLGVGGAVFGAtagglvaaillsflyhefvtankrllktrtrkrqrsnrelikrlviiSIPV 245
Cdd:COG2244 157 SLLLALLLAL-------LGLGLWGLVLKY-----------------------------------------------SLPL 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 246 TLTSALVAMFSTVDSFIyvsrlavagIDEITATMMFGDFTNAETLITIPLVISGNLAVAMIPAISESFAKRDRKEMNEKI 325
Cdd:COG2244 183 LLSGLLGLLLTNLDRLL---------LGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLY 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 326 VLAIRVILLIAFPSCIGLSVLSYGIFNLLFPGSPYGGF-ILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIII 404
Cdd:COG2244 254 RKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAEAApVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVL 333
|
410 420 430
....*....|....*....|....*....|....*
gi 504123335 405 RFITGWIFlsIPFFNIQGIVISSVITFAFLTVANY 439
Cdd:COG2244 334 NLVLNLLL--IPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
20-440 |
1.68e-16 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 81.60 E-value: 1.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 20 ILSRLLGVFFKIPLYQMVGSYGNGIYGNVTSIYNL--LLMVSTVGFPVAISKMVSENVAKKEYATAHRVFKISIAILVVL 97
Cdd:cd12082 5 LLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLiaLLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 98 GTFSSLFLFFGAEWIIEVANWTAESYPA----LVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIRVFLGMLL 173
Cdd:cd12082 85 GLLLAALLLFFSPLILSLLGAEEEVIELaatyLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 174 CwvmVGQFGIGLGVGGAVFGATAGGLVAAILLSFLYhefvtANKRLLKTRTRKRQRSNRELIKRLVIISIPVTLTSALVA 253
Cdd:cd12082 165 I---FGLGPPELGIAGAALATVISYVIGALLLLIYL-----RKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 254 MFSTVDSFIYVSRLAVAGIdeitatmmfGDFTNAETLITIPLVISGNLAVAMIPAISESFAKRDRKEMNEKIVLAIRVIL 333
Cdd:cd12082 237 LGLLIIVAIVAAFGGAAAL---------AAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 334 LIAFPSCIGLSVLSYGIFNLLFPGSPY---GGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRFITGW 410
Cdd:cd12082 308 LIGAVLGLLILLFPEPILSLFTNDPEFlelAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLA 387
|
410 420 430
....*....|....*....|....*....|
gi 504123335 411 IFLSIPFFNIQGIVISSVITFAFLTVANYL 440
Cdd:cd12082 388 YVLAYLGLGLYGIWLALVISLILAALVLLL 417
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
67-444 |
1.91e-16 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 81.34 E-value: 1.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 67 ISKMVSENVAKKEYATAHRVFKISIAILVVLgtfsSLFLFFGAEWIIEV-ANWTAESYPALvAIALA------PLFISFV 139
Cdd:cd13123 58 FSEYLEKEGEEEARRFASRVLTLLLLVLLLL----TLLGILFAPLLVKLlAPGFSGDKFEL-AVALTrimfpyLLFISLS 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 140 SAYRGFFQGFQIMTPTAISQIIEQLIRVFLGMLLCWVMvgqfgiGLGVGGAVFGATAGGLV-AAILLSFLYHefvtankr 218
Cdd:cd13123 133 ALLGGILNAHGRFFAPALAPVLLNLVIIAGLLLLAPLF------DLGIYALAWGVLLGGVLqLLVQLPALRR-------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 219 lLKTRTRKRQRSNRELIKRLVIISIPVTLTSALVAMFSTVDSFIyVSRLAVAGIdeiTAtmmfgdFTNAETLITIPL-VI 297
Cdd:cd13123 199 -LGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVSQINLLVDTIL-ASFLPEGSI---SA------LYYADRLYQLPLgIF 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 298 SGNLAVAMIPAISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFpgsPYGGF----------ILST 367
Cdd:cd13123 268 GVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLF---ERGAFtaedtlmtasALAA 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504123335 368 YSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRFITGWIFlsIPFFNIQGIVISSVITFAFLTVANYLSVKR 444
Cdd:cd13123 345 YALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLL--IKPLGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
364-507 |
2.60e-16 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 75.69 E-value: 2.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 364 ILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRFITGWIFlsIPFFNIQGIVISSVITFAFLTVANYLSVK 443
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLL--IPLFGIVGAAIATVISLLVVALLNLYYLR 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504123335 444 RYTHVDVdFFHILIKPLFAAVIMGILVFYAYKGISALLGGFIGIALSLIIGVLVYSFVLILIRG 507
Cdd:pfam14667 79 RYLGLRL-LLRRLLKPLLAALVMGIVVYLLLLLLGLLLGLALALLLAVLVGALVYLLLLLLLKL 141
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
46-440 |
2.92e-16 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 80.96 E-value: 2.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 46 GNVTSIYNLLLMVSTvGFPVAISKMVSENVAKKEYATAHRVFKISIAILVVLGTFSSLFLFFGAEWIIEVANWTAESYPA 125
Cdd:COG0534 47 GLAFPIFFLLIALGI-GLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLAL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 126 ----LVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEqlirVFLGMLLCWVMVgqFGIGLGVGGAVFGATAGGLVA 201
Cdd:COG0534 126 ardyLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG----NVLNIVLDPLLI--FGGGLGVAGAALATVISQAVS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 202 AILLSFlyheFVTANKRLLKTRtRKRQRSNRELIKRLVIISIPVTLTSALVAMFstvdSFIYVSRLAVAGIDEITAtmmf 281
Cdd:COG0534 200 ALLLLY----YLFRKRSLLRLR-LRDLRPDRKILKRILRIGLPAGLQQLAESLG----FLVLNALVARLGTAAVAA---- 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 282 gdFTNAETLITIPLVISGNLAVAMIPAISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFPGS--- 358
Cdd:COG0534 267 --YGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPevi 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 359 PYGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRFITGWIFLSIPFFNIQGIVISSVITFAFLTVAN 438
Cdd:COG0534 345 ALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLL 424
|
..
gi 504123335 439 YL 440
Cdd:COG0534 425 LL 426
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
76-505 |
1.39e-13 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 73.13 E-value: 1.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 76 AKKEYATAHRVFKISIAILVVLGTFSSLFL-FFGAEWIIEVANWTAESYPALVAIALAPL------FISFVSAYRGFFQG 148
Cdd:TIGR01695 70 AKKKEKEARRAFANTVTTLLILSLLLVVLIgIFFAPFVISLLAPGFADETRSLAVSLTRImfpyllLISLAAVFGGILNA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 149 FQIMTPTAISQIIEQLIrVFLGMLLCWVMVGQFGIGLgvggaVFGATAGGLVAAILLSFlyheFVTANKRLLKTRTRKRQ 228
Cdd:TIGR01695 150 RKRFFIPSFSPILFNIG-VILSLLFFDWNYGQYSLAL-----AIGVLIGGVAQLLIQLP----FLRKAGFLLKPRFNFRD 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 229 RSNRELIKRLviisIPVTLTSAlVAMFSTVDSFIYVSRLAVAGIDEITatmmfgdftNAETLITIPLVISGN-LAVAMIP 307
Cdd:TIGR01695 220 PGLKRFLKLF----LPTTLGSS-ASQITLLINTALASFLEIGSVSALY---------YANRIYQLPLGIFGIsLSTVLLP 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 308 AISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFPGSPYG-------GFILSTYSYATIFMMLSNT 380
Cdd:TIGR01695 286 KLSRHASEGNWNELRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGAFSeedtvmtATILAAYGLGLIFYSLQKV 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 381 FQSILQSIDRFRIPLINLGIAIIIRFITGWIFlsIPFFNIQGIVISSVITFAFLTVANYLSVKRYTHVDVDFFHI--LIK 458
Cdd:TIGR01695 366 LLRAFYARKDTRTPFINSVISVVLNALLSLLL--IFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPFGVLkvLAK 443
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 504123335 459 PLFAAVIMGILVFYAykGISALLGGFIGIALSLIIGVLVYSFVLILI 505
Cdd:TIGR01695 444 LVIASAIIGGVLYLI--VSVSLGGVLVKNLLGLLAIGLIGLLVYFLG 488
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
43-450 |
2.02e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 69.05 E-value: 2.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 43 GIYGNVTSIYNLLLMVSTVGFPVAIskMVSENVAKKEYATahrVFKISIAILVVLgtfsSLFLFFGAEWIIEVANwTAES 122
Cdd:cd13127 36 GLVAMATVFIAFAQLFSDLGLSSAL--IQRKDLTEEDLST---VFWLNLLLGLLL----YLLLFLLAPLIAAFYN-EPEL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 123 YPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIRVFLGMLLCWvmvgqfgIGLGVGGAVFGATAGGLVAA 202
Cdd:cd13127 106 IPLLRVLSLSFLLSGLGSVPRALLQRELRFKKLAIIELISTLVSGVVAIVLAL-------LGFGVWALVAQQLVGALVST 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 203 ILLSFLyhefvtankrllkTRTRKRQRSNRELIKRLVIISIPVTLTSALVAMFSTVDSFIyVSRLavagideITATMMfG 282
Cdd:cd13127 179 VLLWIL-------------SRWRPRLSFSLASLKELLSFGSKLLGSNLLNYFSRNLDNLI-IGKF-------LGAAAL-G 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 283 DFTNAETLITIPL-VISGNLAVAMIPAISEsfAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFpGSPYG 361
Cdd:cd13127 237 YYSRAYRLALLPVqNITGPITRVLFPALSR--LQDDPERLRRAYLKALRLLALITFPLMVGLALLAEPLVLLLL-GEKWL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 362 G--FILSTYSYATIFMMLSNTFQSILQSIDRFRIpLINLGIAIIIRFITGwIFLSIPfFNIQGIVISSVITFAFLTVANY 439
Cdd:cd13127 314 PavPILQILALAGLFQPLSSLNGSLLLALGRTDL-LLKLGLIKAVLTVLA-LLIGIP-YGIIGVAIAYVIASLLSFPLNL 390
|
410
....*....|.
gi 504123335 440 LSVKRYTHVDV 450
Cdd:cd13127 391 YLAGRLIGISL 401
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
236-468 |
1.85e-08 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 56.70 E-value: 1.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 236 KRLVIISIPVTLTSALVAMFSTVDSFIyVSRLAvaGIDEITATmmfgdfTNAETLITIPLVISGNLAVAMIPAISESFAK 315
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLI-VGQFL--GVAALAAV------SNGSPIIFLLTAIGMGLSMGGTILISQYIGA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 316 RDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLL-FPGSPYGGFI--LSTYSYATIFMMLSNTFQSILQSIDRFR 392
Cdd:cd13138 74 KDEEKAKKAVGTLLVLFLILGIVLTILGLLFAPPILRLMnTPAEILELAVsyLRICFLGIPFIFGYNAYSAILRGLGDSK 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504123335 393 IPLINLGIAIIIRFITGWIFLSIPFFNIQGIVISSVITFAFLTVANYLSV-KRYTHVDVDFFHILIKPLFAAVIMGI 468
Cdd:cd13138 154 TPLYFVIIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLrKKKLPFKLSLKDFRFDKEILKEILKI 230
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
231-500 |
7.12e-08 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 54.76 E-value: 7.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 231 NRELIKRLVIISIPVTLTSALVAMFSTVDSfIYVSRLavaGIDEITATmmfgdfTNAETLITIPLVISGNLAVAMIPAIS 310
Cdd:COG0534 3 EGPILKLLLRLALPIILGNLLQSLYGLVDT-IFVGRL---GTAALAAV------GLAFPIFFLLIALGIGLGVGGTALVA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 311 ESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFPGS---PYGGFILSTYSYATIFMMLSNTFQSILQS 387
Cdd:COG0534 73 QALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPevlALARDYLRIILLGLPFLLLFNVLNGILRG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 388 IDRFRIPLINLGIAIIIRFITGWIFLSIPFFNIQGIVISSVITFAFLTVAN-YLSVKRYTHVDVDFFHILIKPLFAAVIM 466
Cdd:COG0534 153 LGDTKTPMIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLlYYLFRKRSLLRLRLRDLRPDRKILKRIL 232
|
250 260 270
....*....|....*....|....*....|....
gi 504123335 467 GIlvfyaykGISALLGGFIGIALSLIIGVLVYSF 500
Cdd:COG0534 233 RI-------GLPAGLQQLAESLGFLVLNALVARL 259
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
46-444 |
8.15e-08 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 54.77 E-value: 8.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 46 GNVTSIYNLLLMVSTvGFPVAISKMVSENVAKKEYATAHRVFKISIAILVVLGTFSSLFLFFGAEWIIEVANWTAESYPA 125
Cdd:cd13138 43 SNGSPIIFLLTAIGM-GLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILEL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 126 LVA----IALAPLFISFVSAYRGFFQGF-QIMTPTaisqiIEQLIRVFLGMLLCWVMVGQFgiGLGVGGAVFgATagglV 200
Cdd:cd13138 122 AVSylriCFLGIPFIFGYNAYSAILRGLgDSKTPL-----YFVIIACVLNIILDLLFIAVF--HMGVAGAAL-AT----V 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 201 AAILLSFLYHEFVTANKRLLKTRTRKRQRSNRELIKRLVIISIPVTLTSALVAMfstvdSFIYVSRLAVA-GIDEITAtm 279
Cdd:cd13138 190 IAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKEILKIGLPSALQQSLVSI-----SFLIINSIVNSyGVVASAA-- 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 280 mfgdFTNAETLITIPLVISGNLAVAMIPAISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFPGS- 358
Cdd:cd13138 263 ----YGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPe 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 359 --PYGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLI-NLGIAIIIRFITGWIFLSIPFFNIQGI----VISSVITF 431
Cdd:cd13138 339 viEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIiSILRLWLVRIPLAYLLSRLTGLGLFGIwlamPISNILSA 418
|
410
....*....|...
gi 504123335 432 AFLTVAnYLSVKR 444
Cdd:cd13138 419 IICIIY-YRKGRW 430
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
20-208 |
1.53e-07 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 53.61 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 20 ILSRLLGVFFKIPLYQMVGSYG------NGIYGNVTSIYNLLLMvstvGFPVAISKMVSENVAKKEYATAHRVFKISIAI 93
Cdd:COG0534 239 GLQQLAESLGFLVLNALVARLGtaavaaYGIALRIESLAFMPAL----GLGQAAQPLVGQNLGAGDYDRARRAARLALLL 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 94 LVVLGTFSSLFLFFGAEWIIEV----ANWTAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIrvfL 169
Cdd:COG0534 315 ALGIGLLLALLLFLFPEPIIGLftddPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWL---V 391
|
170 180 190
....*....|....*....|....*....|....*....
gi 504123335 170 GMLLCWVMVgqfGIGLGVGGAVFGATAGGLVAAILLSFL 208
Cdd:COG0534 392 RLPLAYLLA---FLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
43-444 |
2.49e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 53.30 E-value: 2.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 43 GIYGNVTSIYNLLLMVSTVGFPVAiskmVSENVAKKEYATAHRVFKISIAILVVLGTFSSLFLFFGAEWII-------EV 115
Cdd:cd13140 44 GTAGFFVWLAYALALLSKIGAQVK----VSQSIGAKDEKEARKYARNALQLNLLLGILYGLLLLLFAKPLIgffnlgdAE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 116 ANWTAESYPALVAIALAPLFISFVsaYRGFFQGFQIMTPTAISQIIEQLIRVFLGMLLCwvmvgqFGIG----LGVGGAV 191
Cdd:cd13140 120 VISLAITYLRIVALGLIFSFLNPV--FTGIFNALGDSKTPFIINAIGLVLNIILDPLLI------FGFGpfpaLGVAGAA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 192 FgATagglVAAILLSFLYHEFVTANKRLLKTRTRKRQRSNRELIKRLVIISIPVTLTSALVAMFStvdsfIYVSRLAVAG 271
Cdd:cd13140 192 L-AT----VLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLPVALQSILFALIS-----MILARIIASF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 272 IDEITATMMFGdftnaETLITIPLVISGNLAVAMIPAISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIF 351
Cdd:cd13140 262 GPVAIAAQKVG-----SQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLF 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 352 NLLFPGS---PYGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLInlgIAIIIRF--ITGWIFLSIPFFNIQG---- 422
Cdd:cd13140 337 SLFIPDPetiAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAI---ISIVFNGlrIPLALLLSPTGLGLNGiwwa 413
|
410 420
....*....|....*....|..
gi 504123335 423 IVISSVITFAFLTVANYLSVKR 444
Cdd:cd13140 414 ISISSILKGIILTIWFLLYKKK 435
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-444 |
4.63e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 52.29 E-value: 4.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 46 GNVTSIYNLL---LMVSTVGFPVAISKMVSENVAKKEYATAHRVFKISIAILVVLgtfsSLFLFFGAEWIIEV----ANW 118
Cdd:cd13135 40 GNVTTPFNTItgfLGSISIGFTILGSQSVGAKDIKRINDYAISSIVYNSIIGVIL----FLLWLFGARIIFVLfgvdGQI 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 119 TAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIRVFLGmllcWVMV-GQFGI-GLGVGGAVFGATA 196
Cdd:cd13135 116 LGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVILD----YVLIfGNFGFpRLGIIGAAIATTI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 197 GGLVAAILLSFLyheFVTANKRLLKTRTRKRQRSNRELIKRLVIISIPVTLTSALVAMFStvdsfiyvsrLAVAGIDEIT 276
Cdd:cd13135 192 ANVLNLIILVYL---CRKIKKLTFKLSNTKVLKANIRPYKFTIKLGLPLGGEEFLWNIGN----------LAVIRILNRI 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 277 ATMMFGDFTNAETLITIPLVISGNLAVAMIPAISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFP 356
Cdd:cd13135 259 GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAAIVFLAFPYKILSLFTN 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 357 GSP---YGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRFITGWIFLSIPFFNIQGIVISSVITFAF 433
Cdd:cd13135 339 DPElinYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTIIVVSVALLLIFVFKLGLAGVYITLFIDEII 418
|
410
....*....|.
gi 504123335 434 LTVANYLSVKR 444
Cdd:cd13135 419 RAIINFLKYRK 429
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
236-438 |
7.41e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 51.74 E-value: 7.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 236 KRLVIISIPVTLTSALVAMFSTVDSFIyVSRLavaGIDEITATMMFGdftnaeTLITIPLVISGNLAVAMIPAISESFAK 315
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFM-VGRL---GAEAIAAVGLAT------QVLWLLLVLNMALGTGTVALVSQSYGA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 316 RDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFPGS---PYGGFILSTYSYATIFMMLSNTFQSILQSIDRFR 392
Cdd:cd13137 71 GDYERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPeviALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTK 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 504123335 393 IPLINLGIAIIIRFITGWIF----LSIPFFNIQGIVISSVITFAFLTVAN 438
Cdd:cd13137 151 TPMYIMIIVNVLNIVLDYVLifglWGFPGLGVAGAALATVISRVVGALLL 200
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-258 |
3.14e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 49.62 E-value: 3.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 46 GNVTSIYNLLLMVSTVGfpvaISKMVSENVAKKEYATAHRVFKISIAILVVLGTFSSLFLFFGAEWIIEVANWTAESYPA 125
Cdd:cd13141 53 GNVMFFVMALTQVLNVG----TAALVSHAVGRKDQGEANAVFNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 126 LV--------AIALAPLFISFVSAYRgffqGFQIMTPTAISQIIEqlirVFLGMLLCWVMVGQFGIG--LGVGGAVFGAT 195
Cdd:cd13141 129 ATtylywfipSLALQFILTVLGAALR----GTGIVKPFMVIQILA----VLLNIILAPILITGWGTGraLGVAGAGLASS 200
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504123335 196 AGGLVAAILLsfLYHeFVTANKRLlkTRTRKRQRSNRELIKRLVIISIPVTLTSALVAMFSTV 258
Cdd:cd13141 201 ISVAIAVVLL--LYY-FLRLEKYL--RLDLALWRPDLPTWKRLLKIGLPSGGEFLLTFVYMAV 258
|
|
| MATE_epsE_like |
cd13129 |
Multidrug and toxic compound extrusion family and similar proteins; This model represents a ... |
7-391 |
3.76e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins, including Ralstonia solanaceraum GMI1000 epsE, which may be involved in exporting exopolysaccharide EPS I, a virulence factor. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240534 [Multi-domain] Cd Length: 411 Bit Score: 49.41 E-value: 3.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 7 SYLKGASILVGAGILSRLLGVFFKIPLYQMVGSYGNGIYGNVTSIYNLLLMVSTVGFPVAISKMVSENVAKKEyATAHRV 86
Cdd:cd13129 1 SFASGSFWSLGGLVASRGAVFLTNIMVARSLGKHVFGEFGVIQVTIGLLGTFAGFGLGLAATKVIAETKDVDP-ERAGRI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 87 FKISIAILVVLGTFSSLFLFFGAEWIIEVANWTAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLir 166
Cdd:cd13129 80 IGLSILLAVVTGALAATVLFLSATWIAIATLNAPHLAELLRIAAIILILTAFTGAQTGFLSGFEAFRAIARVNIWAGL-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 167 vfLGMLLCWVMVGQFGIglgvGGAVFGATAGGLVAAiLLSFLYHEFVTANKRLlktrtRKRQRSNRELIKRLVIISIPVT 246
Cdd:cd13129 158 --LLLPLMWIGVYIRGL----VGAVVILLASAAGNV-ASNSLILRRECQNQRG-----PVRTGLTWQELRVLFKFSLPSV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 247 LTSALVAMFSTVDSFIYVSRlaVAGIDEItatmmfGDFTNAETLITIPLVISGNLAVAMIPAISESFAKRDRKeMNEKIV 326
Cdd:cd13129 226 LSGSMGSPVHWIALAILVNQ--PNGYAEL------GLFNAANQWRQFITFLPATLGNVALPFLAENFGNNEGM-FRQTFR 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504123335 327 LAIRVILLIAFPscIGLSVLSYGIFNLLFPGSPYGG--FILSTYSYATIFMMLSNTFQSILQSIDRF 391
Cdd:cd13129 297 SALLFGLGLSLP--LGCVFILASQIFAWLYGKEYGSaaASMRSLAVAAILVGLSVLLGQIIASSGKI 361
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
55-444 |
7.50e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 48.28 E-value: 7.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 55 LLMVSTVGFPVAISKMVSENVAKKEYATAHRVFKISIAILVVLGTFSSLFLFFGAEWII-------EVANwTAESYPALV 127
Cdd:cd13137 48 LLLVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLLALLLSLPLALLGLLFAEPLLrllgadpEVIA-LALTYLRIV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 128 AIALAPLFISFVSAyrGFFQGF-QIMTPTAISqIIEQLIRVFLGMLLcwvMVGQFGI-GLGVGGAVFGATAGGLVAAILL 205
Cdd:cd13137 127 LLGIPFFFLSLVGN--AALRGAgDTKTPMYIM-IIVNVLNIVLDYVL---IFGLWGFpGLGVAGAALATVISRVVGALLL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 206 SFLYhefvtANKRLLKTRTRKRQRSNRELIKRLVIISIPvtltSALVAMFSTVDSFIYVSRLAVAGIDEITAtmmFGDFT 285
Cdd:cd13137 201 LFLL-----LRGRLPIKISFKGFRLDRKIIKKLLRIGLP----AGLEQLLRSLGFLVLLAIVASYGTAALAA---YQIGL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 286 NAETLITIPLViSGNLAVAMIpaISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFPGS---PYGG 362
Cdd:cd13137 269 RIESLAFMPGF-GFSMAASTL--VGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPeviELGV 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 363 FILSTYSYATIFMMLSNTFQSILQSIDRFRIPLI-NLGIAIIIRFITGWIFLSIPFFNIQGIVISSVITFAFLTVANYLS 441
Cdd:cd13137 346 LYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIiNLISMWLVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYR 425
|
...
gi 504123335 442 VKR 444
Cdd:cd13137 426 FRK 428
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
236-448 |
8.54e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 48.27 E-value: 8.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 236 KRLVIISIPVTLTSALVAMFSTVDSFI--YVSRLAVAGIdeitatmmfgdfTNAETLITIPLVISGNLAVAMIPAISESF 313
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMlsRYSDNAVAAV------------GVANQILFLLILIFSFISTGTSILIAQYL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 314 AKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLL-FPGS--PYGGFILSTYSYATIFMMLSNTFQSILQSIDR 390
Cdd:cd13134 71 GAKDKKKARQIAGVALLFNLLLGLVFSLLLLFFGAELLRLMgLPPEllALGSTYLRIVGGSLFLQALSLTLSAILRSHGR 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504123335 391 FRIPLINLGIAIIIRFITGWIFL----SIPFFNIQGIVISSVITFAFLTVANYLSVKRYTHV 448
Cdd:cd13134 151 TKIPMYVSLIMNILNIVGNYLLIfgwfGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKI 212
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
171-444 |
2.40e-05 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 46.90 E-value: 2.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 171 MLLCWVMVGQFGIGLGVGGAVFGATAGGLVAAILLSFLYHefvTANKRLLKTRTRKRQRSNRELIKRLVIISIPVTLTSA 250
Cdd:pfam03023 135 VLLNVGVILTLLLLANYLGNAIYALAIGVLIGGVLQLLVQ---LPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 251 lVAMFSTVDSFIYVSRLAVAGIdeitATMMfgdftNAETLITIPLVISGN-LAVAMIPAISESFAKRDRKEMNEKIVLAI 329
Cdd:pfam03023 212 -VSQLNLLIDTFLASFLAPGSV----SYLY-----YADRIYQLPLGIFGVsISTVLLPRLSRHAADGDWDEFRDLLDQAI 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 330 RVILLIAFPSCIGLSVLSYGIFNLLFPGSP-------YGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAI 402
Cdd:pfam03023 282 RLTLLLMIPVSFGLLVLSIPIVSLLFERGNfspedvtATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISA 361
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 504123335 403 IIRFITGWIFlsIPFFNIQGIVISSVITFAFLTVANYLSVKR 444
Cdd:pfam03023 362 VLNILLSLLL--LPPLGVAGLALATSLSSLIGLVFLYYILRK 401
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
12-446 |
5.13e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 45.61 E-value: 5.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 12 ASILVGAGILSRLLGVFFKIPLYQM-VGSYGNGIYGNVTSIYNLLLMVSTVGFPVAISKMVSENVAKKEYATahRVFKIS 90
Cdd:cd13125 2 VSSLSGISTLIKILAGLIINKVVAVyLGPSGVALLGQLQNFVTILQTIAGGGINNGVVKYTAEYKDDEEKLA--RVWSTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 91 IAILVVLGTFSSLFLFFGAEWIIEVANWTAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEqlirVFLG 170
Cdd:cd13125 80 FRITLILSILGGLLLLLFSKPLSSLLFGDIDYSWVFILLGLALPLFALNNLLLAILNGLKEIKRYALINIIS----SLIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 171 MLLCWVMVGQFGIGLGVGGAVFGATAGGLVAAILLsflyhefvtaNKRLLKTRTRKRQRSNRELIKRLVIISIpVTLTSA 250
Cdd:cd13125 156 LLVSVLLVYFYGLKGALLALVLNQSLIFLVTLIYS----------RKQPWFKLKYLWGRLDKDIIKKLLKFSL-MALVSA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 251 LVAMFStvdsfIYVSRLAVAGIDEITATMMFgdftnaETLITIP----LVISGNLAVAMIPAISesfAKRDRKEMNEKIV 326
Cdd:cd13125 225 LSLPLS-----QIIVRNILIRQLGWEAAGYW------QAVWKISdvylGFITTALSTYYLPRLS---AIKDNKELKREVN 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 327 LAIRVILLIAFPSCIGLSVLSYGIFNLLF-----PGSPYGGFILStysyATIFMMLSNTFQSILQSIDRFRIPLInLGIA 401
Cdd:cd13125 291 KQLKVILPLVAIGALLIYLLRDLIIQILFseeflPARELFLWQLI----GDFFKIASWLLGYILLAKGMTKLFII-TEIL 365
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 504123335 402 IIIRFITGwIFLSIPFFNIQGIVISSVITFAFLTVANYLSVKRYT 446
Cdd:cd13125 366 FALLFVLL-SLLFIPLFGLEGAGIAYAINYILYLILMYFIFRKLL 409
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
43-355 |
5.87e-05 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 45.28 E-value: 5.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 43 GIYGNVTSIYNLLLMVSTVGFPVAISKMvsENVAKKEYATahrVFKISIailvVLGTFSSLFLFFGAEWIIEVANwTAES 122
Cdd:pfam13440 12 GVVAIATVVISFANIFVDMGFSSALIQK--KDITETDYST---VFTFNL----IFGALIYLILFALAPLIASFYN-QPEL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 123 YPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIRVFLGMLLCWvmvgqfgIGLGVGGAVFGATAGGLVAA 202
Cdd:pfam13440 82 VPVLRVLALVLILNGLSSVQTALLRRDLRFKKLFKITLTSSVIGGIVGIVLAY-------LGFGVWALVIGTLAQQLLSL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 203 ILLSFLYhefvtankrllktRTRKRQRSNRELIKRLVIISIPVTLTSALVAMFSTVDSFIyvsrlavagIDEITATMMFG 282
Cdd:pfam13440 155 VLLWLAS-------------DWRPRLTFSLKVIKELFSFGSWLLLSNLLNYLARNLDNLI---------IGKVLGTAALG 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504123335 283 DFTNAETLITIPL-VISGNLAVAMIPAISEsfAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLF 355
Cdd:pfam13440 213 LYSVAYRLALLPTaNITSVITKVLFPALSR--IQDDKAKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVLL 284
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
21-210 |
6.35e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 45.58 E-value: 6.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 21 LSRLLGVFFKIPLYQMVGSYGNGI---YGNVTSIYNLLLMVStVGFPVAISKMVSENVAKKEYATAHRVFKISIAILVVL 97
Cdd:cd13137 237 LEQLLRSLGFLVLLAIVASYGTAAlaaYQIGLRIESLAFMPG-FGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLF 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 98 GTFSSLFLFFGAEWIIEV----ANWTAESYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQ-LIRVFLGML 172
Cdd:cd13137 316 MGLLGLLLFIFAPPLASLftpdPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMwLVRLPLAYL 395
|
170 180 190
....*....|....*....|....*....|....*...
gi 504123335 173 LCWVMvgqfgiGLGVGGAVFGATAGGLVAAILLSFLYH 210
Cdd:cd13137 396 LGFVL------GLGLTGIWLAMFVDTIVRAILLLYRFR 427
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
35-436 |
7.00e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 45.19 E-value: 7.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 35 QMVGSYGNGIYGNVTSIYNLLLMVSTVgFPVAISKMVSENVAKKEYATAHRVFKISIAILVVLGTFSSLFLFFGAEWIIE 114
Cdd:cd13143 33 HGVGALALAAVNLVFPIIMLLMALGLM-IGVGGASLISRRLGAGDREKANRIFSTALLLSLILGLLLTILGLLFLDPLLR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 115 VANWTAESYPaLVAIALAPLFISfvsayrGFFQGFQIMTPTAIS-------QIIEQLIRVFLGMLLCWVMVGQFgiGLGV 187
Cdd:cd13143 112 LLGASGELLP-YAVDYLRIILLG------APFTILSSVLNNLLRaegkpklAMLGMLIGAVLNIILDPLFIFVL--GLGI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 188 GGAVFgATAGGLVAAILLSFLYHefvtANKRLLKTRTRKRQRSNRELIKRLVIISIP---VTLTSALVAMFSTVDSFIYV 264
Cdd:cd13143 183 AGAAL-ATVIAQLISLLLLLLYF----FRGKSLLKLSLLRFKLSLKIIKEILALGFPsflMQLSSSVVTIVLNLTLLGYG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 265 SRLAVAGideitatmmFGDFTNAETLITIPLVisgNLAVAMIPAISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLS 344
Cdd:cd13143 258 GDIGVAA---------FGIVTRILTFLFLPLI---GLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 345 VLSYGIFNLLFPGS---PYGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRFITGWIFLSIpFFNIQ 421
Cdd:cd13143 326 LFPEQIVSLFTDDPeliALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPR-LFGLD 404
|
410
....*....|....*
gi 504123335 422 GIVISSVITFAFLTV 436
Cdd:cd13143 405 GIWLAFPLAEILTLL 419
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
50-440 |
1.14e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 44.83 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 50 SIYNLLLMVSTVGFPVAISKMVSENVAKKEYATAHRVFKISIAILVVLGTFSSLFLFFGAEWIIEVANWTAESYPALVA- 128
Cdd:cd13133 47 GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEy 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 129 --IALAPLFISFVS-AYRGFFQGFQIMTPTAISQIIEQLIRVFLGMLLcwvMVGQFGI-GLGVGGAVFGATAGGLVAAIL 204
Cdd:cd13133 127 frIRILGAPFSLLGaALRAFFSGIGRTRVVMVANLVMVVVNIVLDYAL---IFGKLGFpAMGIAGAAIATVIAEAVSLLF 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 205 LSFLYheFVTANKRllKTRTRKRQRSNRELIKRLVIISIPVTLTSaLVAMFSTVDSFIYVSRLavaGIDEITATMMfgdF 284
Cdd:cd13133 204 FLLLL--FRRKNRR--RFGLRRAWRFDRELLRRILRLGLPSGLQF-FLDVGAFTVFFLLIGRL---GTTELAATNI---V 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 285 TNAETLITIPLVisgNLAVAMIPAISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLSYGIFNLLFPGS------ 358
Cdd:cd13133 273 FSINSLAFLPMI---GLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLGILFLLFPELLLSIFTPGAdfalia 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 359 PYGGFILSTYSYATIFMMLSNTFQSILQSIDRFRIPLINLGIAIIIRFITGWIFLSIPFFNIQGIVISSVITFAFLTVAN 438
Cdd:cd13133 350 ELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYLLVVLGAGLAGAWTVETVYVIVLALIF 429
|
..
gi 504123335 439 YL 440
Cdd:cd13133 430 LL 431
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
41-209 |
1.70e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 43.99 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 41 GNGIYGNVTSIYNLLLMvstvGFPVAISKMVSENVAKKEYATAHRVFKISIAILVVLGTFSSLFLFFGAEWII------- 113
Cdd:cd13138 262 AYGIANKINSFAFLPPS----AIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLglftsdp 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 114 EVANWTAEsypALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQ-LIRVFLGMLLCWVMvgqfgiGLGVGGAVF 192
Cdd:cd13138 338 EVIEIGAE---YLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLwLVRIPLAYLLSRLT------GLGLFGIWL 408
|
170
....*....|....*..
gi 504123335 193 GATAGGLVAAILLSFLY 209
Cdd:cd13138 409 AMPISNILSAIICIIYY 425
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-354 |
3.26e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 40.18 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 36 MVGSYGN---GIYGNVTSIYNLLLMVSTVgFPVAISKMVSENVAKKEYATAHRVFKISIAILVVLGTFSSLFLFFGAEWI 112
Cdd:cd13134 29 MLSRYSDnavAAVGVANQILFLLILIFSF-ISTGTSILIAQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLLLFFGAEL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 113 IEVANWTAE----SYPALVAIALAPLFISFVSAYRGFFQGFQIMTPTAISQIIEQLIRVFLGMLLcwvMVGQFGI-GLGV 187
Cdd:cd13134 108 LRLMGLPPEllalGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVGNYLL---IFGWFGLpKLGV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 188 GGAVFGATAGGLVAAILLSFLYHEFVTANKRLLKTRTRkrqrsNRELIKRLVIISIPVTLTSALVAMFSTVDSFIYvsrl 267
Cdd:cd13134 185 AGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPF-----PKKLLKKILKIGLPSAGEELSYNLSQTVITAFI---- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504123335 268 AVAGIDEITAtmmfgdFTNAETLITIPLVISGNLAVAMIPAISESFAKRDRKEMNEKIVLAIRVILLIAFPSCIGLSVLS 347
Cdd:cd13134 256 ARLGTAALAA------RTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALLLALFR 329
|
....*..
gi 504123335 348 YGIFNLL 354
Cdd:cd13134 330 EPILGLF 336
|
|
| |
