type VI secretion system Vgr family protein such as type VI secretion system tip protein VgrG, a core component and effector of Type VI secretion systems (T6SSs) that are involved in the pathogenicity of several Gram-negative bacteria
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly ...
25-769
4.13e-158
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly [Intracellular trafficking, secretion, and vesicular transport, Mobilome: prophages, transposons, General function prediction only];
:
Pssm-ID: 442724 [Multi-domain] Cd Length: 743 Bit Score: 479.26 E-value: 4.13e-158
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly ...
25-769
4.13e-158
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly [Intracellular trafficking, secretion, and vesicular transport, Mobilome: prophages, transposons, General function prediction only];
Pssm-ID: 442724 [Multi-domain] Cd Length: 743 Bit Score: 479.26 E-value: 4.13e-158
Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with ...
37-520
1.03e-92
Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with some classes of Rhs elements. This model does not include a large octapeptide repeat region, VGXXXXXX, found in the Vgr of Rhs classes G and E.
Pssm-ID: 273730 [Multi-domain] Cd Length: 483 Bit Score: 300.16 E-value: 1.03e-92
Uncharacterized protein conserved in bacteria (DUF2345); Members of this family are found in ...
611-760
8.92e-51
Uncharacterized protein conserved in bacteria (DUF2345); Members of this family are found in various bacterial hypothetical proteins, as well as Rhs element Vgr proteins.
Pssm-ID: 431059 [Multi-domain] Cd Length: 151 Bit Score: 175.02 E-value: 8.92e-51
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly ...
25-769
4.13e-158
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly [Intracellular trafficking, secretion, and vesicular transport, Mobilome: prophages, transposons, General function prediction only];
Pssm-ID: 442724 [Multi-domain] Cd Length: 743 Bit Score: 479.26 E-value: 4.13e-158
Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with ...
37-520
1.03e-92
Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with some classes of Rhs elements. This model does not include a large octapeptide repeat region, VGXXXXXX, found in the Vgr of Rhs classes G and E.
Pssm-ID: 273730 [Multi-domain] Cd Length: 483 Bit Score: 300.16 E-value: 1.03e-92
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
31-513
2.57e-69
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.
Pssm-ID: 274542 [Multi-domain] Cd Length: 513 Bit Score: 238.25 E-value: 2.57e-69
Uncharacterized protein conserved in bacteria (DUF2345); Members of this family are found in ...
611-760
8.92e-51
Uncharacterized protein conserved in bacteria (DUF2345); Members of this family are found in various bacterial hypothetical proteins, as well as Rhs element Vgr proteins.
Pssm-ID: 431059 [Multi-domain] Cd Length: 151 Bit Score: 175.02 E-value: 8.92e-51
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D ...
45-353
3.48e-49
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D proteins and related bacterial sequences. This family also includes Bacteriophage Mu P proteins and related sequences. This protein forms the phage central baseplate hub.
Pssm-ID: 428689 Cd Length: 302 Bit Score: 175.96 E-value: 3.48e-49
Type VI secretion system/phage-baseplate injector OB domain; Family of bacterial and phage ...
409-471
6.27e-08
Type VI secretion system/phage-baseplate injector OB domain; Family of bacterial and phage baseplate assembly proteins responsible for forming the small spike at the end of the tail or bacterial pathogenic needle-shaft. This entry represents the OB fold part of the structure. This structure contains an unusual extra beta hairpin that forms the foundation of the spike protein's beta helix.
Pssm-ID: 428084 [Multi-domain] Cd Length: 75 Bit Score: 50.27 E-value: 6.27e-08
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
Click on the triangle to view details about the feature, including a multiple sequence alignment
of your query sequence and the protein sequences used to curate the domain model,
where hash marks (#) above the aligned sequences show the location of the conserved feature residues.
The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
Click on the triangle for interactive 3D structure viewing options.
Functional characterization of the conserved domain architecture found on the query.
Click here to see more details.
This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
(labeled illustration) or all hits
(labeled illustration).
Domains are color coded according to superfamilies
to which they have been assigned. Hits with scores that pass a domain-specific threshold
(specific hits) are drawn in bright colors.
Others (non-specific hits) and
superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
with the same color and shade of the domain or superfamily that provides the annotation. Mouse over the colored bars or triangles to see descriptions of the domains and features.
click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
mapped to the query sequence.
Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
(CDART).
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