|
Name |
Accession |
Description |
Interval |
E-value |
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
1-393 |
0e+00 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 596.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 1 MTPSNASTPQAHQAARPNWSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIR 80
Cdd:PRK10213 1 MSEFIAENRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 81 STDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIA 160
Cdd:PRK10213 81 ATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 161 APLGSFLGGIIGWRNVFNGAAVMGVVCTIWVLKALPSLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIR 240
Cdd:PRK10213 161 APLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 241 PVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFA 320
Cdd:PRK10213 241 PVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503993318 321 LIPVGWSTWITRSLSDQAEKAGSIQVAVIQLANTCGAAVGGVALDHLGLLSPLVLSGTLMLLTGLLVATKVRV 393
Cdd:PRK10213 321 LVPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKM 393
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-375 |
2.21e-63 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 207.40 E-value: 2.21e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 22 VFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLL 101
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 102 VSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAA 181
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 182 VMGVVCTIWVLKALPSLPGE---STSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVL 258
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKkpgSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 259 LSFGIASFVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWITRSLSDQA 338
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
|
330 340 350
....*....|....*....|....*....|....*..
gi 503993318 339 EKAGSIQVAVIQLANTCGAAVGGVALDHLGLLSPLVL 375
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWV 357
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
14-369 |
7.81e-41 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 148.50 E-value: 7.81e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 14 AARPNWSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSV 93
Cdd:PRK03545 3 SRKVAWLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 94 LLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGW 173
Cdd:PRK03545 83 LFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 174 RNVFNGAAVMGVVCTIWVLKALPSLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDG 253
Cdd:PRK03545 163 RTTFLAIGGGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 254 LTLVLLSFGIASFVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWITRS 333
Cdd:PRK03545 243 ATLLLLLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLKL 322
|
330 340 350
....*....|....*....|....*....|....*.
gi 503993318 334 LSDQAEKAGSIQVAVIQLANTCGAAVGGVALDHLGL 369
Cdd:PRK03545 323 APDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-338 |
2.05e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 119.31 E-value: 2.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 13 QAARPNWSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFS 92
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 93 VLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIG 172
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 173 WRNVFNGAAVMGVVCTIWVLKALP-SLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDV 251
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPeSRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 252 DGLTLVLLSFGIASFVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWIT 331
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
....*..
gi 503993318 332 RSLSDQA 338
Cdd:COG2814 323 ELAPPEA 329
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
22-314 |
1.44e-21 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 95.16 E-value: 1.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 22 VFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLL 101
Cdd:PRK10091 5 ILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 102 VSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAA 181
Cdd:PRK10091 85 FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 182 VMGVVCTIWVLKALPSLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSF 261
Cdd:PRK10091 165 VFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLV 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 503993318 262 GIASFVGTSLSSMLLKRSVKAALA-VAPVVLAISAAVLVLWGESKIVASTVAVI 314
Cdd:PRK10091 245 GLGMVLGNLLSGRLSGRYSPLRIAaVTDFIIVLALLMLFFFGGMKTASLIFAFI 298
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-366 |
1.85e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.02 E-value: 1.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 25 VAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSF 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 105 ANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFL--GGIIGWRNVFNGAAV 182
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 183 MGVVCTIWVLKALPSLPGE---------STSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDG 253
Cdd:cd06174 161 LALLAAILLLLVVPDPPESarakneeasSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 254 LTLVLLSFGIASFVGTSLSSMLLKR--SVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWIT 331
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRliGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350
....*....|....*....|....*....|....*
gi 503993318 332 RSLSDQAEKAGSIQVAVIQLANTCGAAVGGVALDH 366
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-322 |
5.07e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 84.93 E-value: 5.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 19 WSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLS 98
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 99 CLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFN 178
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 179 GAAVMGVVCTIWVLKALPSLPGESTSAQQ----NMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGL 254
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAKaslrDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503993318 255 TLVLLSFGIASFVGTSLSSMLLKR-SVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALI 322
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRiGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGG 312
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
26-376 |
5.24e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 81.85 E-value: 5.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 26 AFCVACLITVEFLPVSLLTP----MAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLL 101
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPalpaIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 102 VSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAA 181
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 182 VMGVVCTIWVLKALP-SLPGESTSAQ-----QNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLT 255
Cdd:cd17320 161 LLGLLLLLLVLLFLPeTLPEEKRKPLlssllRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 256 LVLLSFGIASFVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGW--STWITRS 333
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLifPNATSLA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 503993318 334 LSDQAEKAGSIQvAVIQLANTCGAAVGGVALDHLGLLSPLVLS 376
Cdd:cd17320 321 LEPFPHVAGTAS-ALLGFLQFLIGALAGALVGLLPNGTALPMG 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
37-334 |
4.35e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.61 E-value: 4.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 37 FLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRA 116
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 117 CLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVLKALP 196
Cdd:pfam07690 94 LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 197 SLPGESTSAQQ-------NMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFVGT 269
Cdd:pfam07690 174 PPESKRPKPAEearlsliVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL-PLYQEVLGLSALLAGLLLGLGGLLGAIGR 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503993318 270 SLSSMLLKR---SVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWITRSL 334
Cdd:pfam07690 253 LLLGRLSDRlgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
25-376 |
1.46e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 77.23 E-value: 1.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 25 VAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSF 104
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 105 ANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMG 184
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 185 VVCTIWVLKALP-------SLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMT-LAGFDVDGLTL 256
Cdd:cd17325 161 LLALVLALLLLPeprpppnKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFL-PLYAAeLGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 257 VLLSFGIASFVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWITRSLSD 336
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 503993318 337 QA-EKAGSIQVAVIQLANTCGAAVGGVALDHLGLLSPLVLS 376
Cdd:cd17325 320 EGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-375 |
1.14e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 74.52 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 19 WSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLS 98
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 99 CLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFN 178
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 179 GAAVMGVVCTIWvlkalpslpgestsaqqnmfgllkrpGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVL 258
Cdd:COG2271 169 ILGLPGLLLALL--------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 259 LSFGIASFVGTSLSSML---LKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWITRSLS 335
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLsdrLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPK 302
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 503993318 336 DQAEKAGSIQVAVIQLANTCGAAVGGVALDHLGLLSPLVL 375
Cdd:COG2271 303 KARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
37-368 |
7.61e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 72.24 E-value: 7.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 37 FLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRA 116
Cdd:cd17489 13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 117 CLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCT--IWVLKA 194
Cdd:cd17489 93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALllVFLVKD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 195 LPSLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLlsFGIASFVGTSLSSM 274
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFL-PLYAAERGISNAGLFFTV--YAIALLLSRPFSGK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 275 LLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAF-ALIPVGWSTWITRSLSDQAEKAGSIQVAVIQLAN 353
Cdd:cd17489 250 LSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFgLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGI 329
|
330
....*....|....*
gi 503993318 354 TCGAAVGGVALDHLG 368
Cdd:cd17489 330 GLGGLLLGLVAELFG 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
41-375 |
3.26e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.27 E-value: 3.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 41 SLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGL 120
Cdd:COG0738 29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 121 ALGGFWAMSASLTMRLVPmRVVPKALSVIFGAVSIALVIAAPLGSFL---GGIIGWRNVFNGAAVMGVVCTIWV----LK 193
Cdd:COG0738 109 GLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYLILAVLLLLLALLFlrskLP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 194 ALPSLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSS 273
Cdd:COG0738 188 EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 274 MLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALI-PVGWStWITRSLSDQAEKAGSIQVAVIQLA 352
Cdd:COG0738 268 FLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMfPTIFS-LALDGLGKRTAAAVSAVLIMGIVG 346
|
330 340
....*....|....*....|...
gi 503993318 353 NTCGAAVGGVALDHLGLLSPLVL 375
Cdd:COG0738 347 GAIGPPLIGFLADAFGLRAAFLV 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-333 |
3.94e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 63.74 E-value: 3.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 25 VAFCVACLITveFLPVSLLTP----MAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCL 100
Cdd:cd17474 2 YAVFFATLLA--VLGVSIVDPilpaIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 101 LVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGiIGWRNVFNGA 180
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 181 AVMGVVC--TIWVLKALPSLPGESTSAQQ--NMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTL 256
Cdd:cd17474 159 AALIPVAflAILFLLPEPKEKAKSSSATKlrDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503993318 257 VLLSFGIASFVGTSLSSMLLKR--SVKAALAVAPVVLAISAAVLvLWGESKIVASTVAVIWGFAFALIPVGWSTWITRS 333
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRLLKKrfGARRILVIGLLLYALSLLLL-GFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTEL 316
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
4-360 |
4.88e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 63.74 E-value: 4.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 4 SNASTPQAHQAARPNWSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTD 83
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 84 RRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRvVPKALSVIFGAVSIALVIAAPL 163
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 164 GSFLGGIIGWRNVFNGAAVMGVVCTIWVLKALPSLPGESTSAQQN--MFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrP 241
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAasLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWL-P 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 242 VYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFAL 321
Cdd:COG2807 240 PILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG 319
|
330 340 350
....*....|....*....|....*....|....*....
gi 503993318 322 IPVGWSTWITRSLSDQAEkAGSIqVAVIQLANTCGAAVG 360
Cdd:COG2807 320 LFPLALTLIGLRARTPAE-AAAL-SGMAQSVGYLLAALG 356
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
43-364 |
5.82e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 63.36 E-value: 5.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 43 LTPMAQDLGISEgVAGQSVTTTAFVAMFASLFITS-IIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLA 121
Cdd:cd17503 19 LPTIMGDLGASL-DTVQWVITSYLLALAIMIPLSGwLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 122 LGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIwvlkALPSLPge 201
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALL----LAPLLD-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 202 stsaqqnmFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKR-SV 280
Cdd:cd17503 172 --------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKfGP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 281 KAALAVAPVVLAISAAVLVLWGESKIVA--STVAVIWGFAFALIPVGWSTWITRSLS-DQAEKAGSIQVAVIQLANTCGA 357
Cdd:cd17503 244 RLLLLAGLLLLALGTLLLAFLTPDTSLWliILPLFIRGLGMGLVFMPLNTLALNSLPpEQIGDATALFNTIRQLGGSIGT 323
|
....*..
gi 503993318 358 AVGGVAL 364
Cdd:cd17503 324 ALLATLL 330
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-364 |
1.31e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 62.21 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 46 MAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGF 125
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 126 wAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIwvlkALPSLPgestsa 205
Cdd:cd17504 102 -PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA----LVPLID------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 206 qqnmFGLLKRPGVMAGMCAIFMAFAGQFAFFtYIRPVYM-----TLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKR-S 279
Cdd:cd17504 171 ----LRLLRRRNVLLANITALLAGFGMFMVF-QLLPQLLqlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARvG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 280 VKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWITRSLSDQAEkagSIQVAVIQLANTCGAAV 359
Cdd:cd17504 246 PRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRT---GIATGMNTVLRTIGSAI 322
|
....*
gi 503993318 360 GGVAL 364
Cdd:cd17504 323 GPAIA 327
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
47-325 |
8.24e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.92 E-value: 8.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 47 AQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFW 126
Cdd:cd17316 28 EFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 127 AMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFL----GGIIGWRNVFNGAAVMGVVctiwvlkalpslpges 202
Cdd:cd17316 108 PGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRILFLIGALPALL---------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 203 tsaqqnmfGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKR-SVK 281
Cdd:cd17316 172 --------ALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRiGRK 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 503993318 282 AALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVG 325
Cdd:cd17316 244 KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWG 287
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
47-245 |
2.82e-09 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 58.33 E-value: 2.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 47 AQDLGISEGVAGQSVTTTAFVAMFASLFITSII-RSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLgracLGLALGGF 125
Cdd:cd17471 24 TEELGASPLQIGIFMTLSALSGIVVSQWLGRLSdRGGDRKPLILLALLAGALGYLLFAFLRNYWVLLL----VGVVLLSL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 126 WAMSASLTMRLV-------PMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVLKALPSL 198
Cdd:cd17471 100 GAAAFPQLFALAreyadrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSV 179
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 503993318 199 PGESTSAQQN--MFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMT 245
Cdd:cd17471 180 KPPAQKATPAssLVKAPVNRRLLLLFAAFTLLFAANSMYIIAM-PLYVT 227
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-301 |
9.64e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.97 E-value: 9.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 8 TPQAHQAARPNWSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYV 87
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 88 VILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFL 167
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 168 GGIIGWRNVFNGAAVMGVVCTIWVLKALPSLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLA 247
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 503993318 248 GFDVDGLTLVLLSFGIASFVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLVLW 301
Cdd:COG0477 242 LLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
85-376 |
5.51e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.14 E-value: 5.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 85 RYVVILFSVLLTLSCLLVSF-ANSFALLLLGRAclglaLGGFWAMSA---SLTMRLVPMRVVPKALSVIFGAVSIALVIA 160
Cdd:cd17472 61 RKPVILFGLLLFIAGSLLAAyATSIYGLILGRA-----LQGSGAISSvvmALLADLTREENRTKAMALIGASIGIAFAIS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 161 APLGSFLGGIIGWRNVFNGAAVMGVVC---TIWVLKALPSLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFT 237
Cdd:cd17472 136 MVLGPLLAAHLGVSGLFLITAILSLVSlliLLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFY 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 238 YIrPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLL--KRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIW 315
Cdd:cd17472 216 IL-PLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAekKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIF 294
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503993318 316 GFAFALIPVGWSTWITRSLSDQAEKAGSIQVAVIQ-LANTCGAAVGGVALDHLGLLSPLVLS 376
Cdd:cd17472 295 FIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQfLGSFLGGALGGLLWGLLGYSSVFLTI 356
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
85-368 |
9.23e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 53.34 E-value: 9.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 85 RYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLG 164
Cdd:cd17319 68 RKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 165 SFLGGIIGWRNVFNGAAVMGVVCTIWVLKALPSlpgestsaqqnmfgllkrpgvMAGMCAIFMAFAGQFAFFTYIRPVYM 244
Cdd:cd17319 148 GWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---------------------VWGLALGYFGINYALYGLLTWLPTYL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 245 -TLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKRSVKAA---LAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFA 320
Cdd:cd17319 207 kQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGArrlVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIG 286
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 503993318 321 LIPVGWSTWITRSLSD-QAEKAGSIQVAVIQLANTCGAAVGGVALDHLG 368
Cdd:cd17319 287 AASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVDATG 335
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
61-322 |
2.47e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.19 E-value: 2.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 61 VTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFwaMSASLTM------ 134
Cdd:cd17473 41 LTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGI--MTLATALigdyfe 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 135 ---RLvpmrvvpKALSVIFGAVSIALVIAAPLGSFLGGiIGWRNVFnGAAVMGVVCTIWVLKALPSLPGESTSAQQNMFG 211
Cdd:cd17473 119 geeRA-------KMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPF-LVYLLALPVLILVLLFLPEPARKSKSAASPGAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 212 LLKRPGVMAGMCAIFMAFAGQFAFF---TYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKRSVKAALAVAP 288
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYvipIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
250 260 270
....*....|....*....|....*....|....
gi 503993318 289 VVLAISAAVLVLWGESKIVASTVAVIWGFAFALI 322
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLL 303
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
84-362 |
3.19e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.79 E-value: 3.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 84 RRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPL 163
Cdd:cd17321 60 RKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 164 GSFLGGIIGWRNVFNGAAVMGVVCTIWVlkalpslpgestsaqqnmfgllkrPGVMAGMCAIFMAFAGQFAFFTYIRPVY 243
Cdd:cd17321 140 GGLLLELFGWRWIFLINVPIGLVALLLA------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 244 MTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKR-SVKAALAVAPVVLAISAAVLVLWGESKIVASTVA--VIWGFAFA 320
Cdd:cd17321 196 QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRfGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPglVLLGLGLG 275
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 503993318 321 LIPVGWSTWITRSL-SDQAEKAGSIQVAVIQLANTCGAAVGGV 362
Cdd:cd17321 276 LFATPLTNAALSSVpKEKAGAASGILNTARQLGGALGVALLGA 318
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
36-299 |
4.95e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.47 E-value: 4.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 36 EFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGR 115
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 116 ACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFgavsialvIAAPLGSFLGGIIG---------WRNVFNGAAVMGVV 186
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY--------FAIPLGSGLGYVVGglvaqatggWRWAFRVTGVLGVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 187 CTIWVL-----------KALPSLPGESTSAQQNMFGLLKRPGVM----AGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDV 251
Cdd:cd17328 167 LAILLLlfvrepprgaaEGGVMAKSTATSFLADLKALAKNPSFIlstlGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSA 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 503993318 252 DGLTLVLLSFGIASFVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLV 299
Cdd:cd17328 247 DVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAA 294
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
61-196 |
5.06e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 48.80 E-value: 5.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 61 VTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMR 140
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 503993318 141 VVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVLKALP 196
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
46-368 |
1.17e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 46 MAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRY-----VVILFSVLLTLSCLLVSFANSFAllllGRACLGL 120
Cdd:COG2211 37 YTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLS----PTGKLIY 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 121 ALGGFWAMSASLTMRLVPMRVVPKALS---------------VIFGAVSIALVIAAPLGSFLGG--IIGWRNVFNGAAVM 183
Cdd:COG2211 113 ALVTYLLLGLAYTLVNIPYSALGAELTpdyeertrlsswrfaFAGLGGLLASVLPPPLVAAFGGdaALGYRLTALIFAVL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 184 GVVCTIWVL---KALPSLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLS 260
Cdd:COG2211 193 GLLAFLLTFfgtKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLAL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 261 FGIASFVGTSLSSMLLKR-SVKAALAVAPVVLAISAAVLVLWGESKIVASTVA-VIWGFAFALIPVGWSTWITRSLSDQA 338
Cdd:COG2211 273 YFLAALLGAPLWPRLAKRfGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLaALAGIGLGAILVLPWAMLADVVDYDE 352
|
330 340 350
....*....|....*....|....*....|....*...
gi 503993318 339 EKAG--------SIQVAVIQLANTCGAAVGGVALDHLG 368
Cdd:COG2211 353 WKTGrrreglyfGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
42-368 |
1.44e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.96 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 42 LLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACL-GL 120
Cdd:cd17355 25 FIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLgGG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 121 ALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVL-------- 192
Cdd:cd17355 105 GAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLlllrrrpa 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 193 -KALPSLPGESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGTSL 271
Cdd:cd17355 185 dLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 272 SSMLLKR-SVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGF-AFALIPVGWSTWITRSLSDQAEKAGSIQVAVI 349
Cdd:cd17355 265 SGWLGDRySPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLgWGATVPLTAALAARYFGARSYGTLFGLVFAPH 344
|
330
....*....|....*....
gi 503993318 350 QLANTCGAAVGGVALDHLG 368
Cdd:cd17355 345 QLGSALGPWLGGLLYDRTG 363
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
45-189 |
2.30e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.12 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 45 PMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGG 124
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGA 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503993318 125 FWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTI 189
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
46-196 |
9.36e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 47.35 E-value: 9.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 46 MAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGF 125
Cdd:TIGR00895 43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503993318 126 WAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVLKALP 196
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-194 |
1.03e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 21 AVFAVAFCVACLITVEFLPVSLLTPMAQD-LGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSC 99
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 100 LLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNG 179
Cdd:cd06173 289 LVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
|
170
....*....|....*
gi 503993318 180 AAVMGVVCTIWVLKA 194
Cdd:cd06173 369 AGALLLLAALLLLLL 383
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-238 |
1.45e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 46.85 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 46 MAQDLGISEGVAGQSVTTTAFVAMFASLFITsiiRSTDR---RYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLAL 122
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAG---WLLDRfgeRRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 123 GGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVLKALPSLPGES 202
Cdd:cd17475 99 GSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAAS 178
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 503993318 203 TSAQQNMF------GLLKRPGVMAGMCAIFMAFAGQFAFFTY 238
Cdd:cd17475 179 AATESASTllrslkEVLRNRDVWLIAIAGALLVAPQFALLTF 220
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
42-323 |
2.91e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 45.76 E-value: 2.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 42 LLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLA 121
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 122 LGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSF-LGGIIGWRNVFNGAAVMGVVCTIWVLKALPSLPG 200
Cdd:cd06180 101 SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAgLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 201 ESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKR-S 279
Cdd:cd06180 181 APTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFL-PLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRwG 259
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 503993318 280 VKAALAVAPVVLAISAAVLVLWGeSKIVASTVAVIWGFAFALIP 323
Cdd:cd06180 260 TRRALAANLLVQAVGVLLPLLSP-GPAGLVLSAVLFGGTFMAIT 302
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
51-325 |
4.63e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 4.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 51 GISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSA 130
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 131 SLTMRLVPMRVVPKALSvIFGAVSIALVIAAPLGSFLGGIIGWRnVFNGAAVMGVVCTIWVLKALPSLPGESTSAQQNMF 210
Cdd:cd17477 107 SWLNALATNENRGRVLG-LYSTVLGLGFALGPLLLALVGTAGAL-PFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 211 GLLKRPGVmaGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKRSVK-AALAVAPV 289
Cdd:cd17477 185 RLLRIAPL--ALLGAFVAGFLEGAFYSLL-PLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRrRVLLGCAL 261
|
250 260 270
....*....|....*....|....*....|....*..
gi 503993318 290 VLAISAAVLVLWGESKIVASTVAVIWG-FAFALIPVG 325
Cdd:cd17477 262 LGALAALLLPLVPGLPLALLVLLFLWGgAAGPLYTLA 298
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
46-300 |
5.17e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 5.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 46 MAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGF 125
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 126 WAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGiIGWRNVFNGAAVMGVVCTIWVLKALP-----SLPG 200
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPetrpkRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 201 ESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGT-SLSSMLLKRS 279
Cdd:cd17329 185 EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQfPVARLVERFR 264
|
250 260
....*....|....*....|.
gi 503993318 280 VKAALAVAPVVLAISAAVLVL 300
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAF 285
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
53-376 |
7.19e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 7.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 53 SEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFA-----NSFALLLLGRACLGLALGGFWA 127
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 128 MSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVM---GVVCTIWVLKALPSLPGESTS 204
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSfllSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 205 AQQNMFG-----LLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKRS 279
Cdd:cd06173 192 LLLRDLReglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 280 VKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWITRSLSDQ-AEKAGSIQVAVIQLANTCGAA 358
Cdd:cd06173 272 RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGAL 351
|
330
....*....|....*...
gi 503993318 359 VGGVALDHLGLLSPLVLS 376
Cdd:cd06173 352 LAGLLADALGLSAVFLLA 369
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
42-278 |
8.04e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.22 E-value: 8.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 42 LLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLA 121
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 122 LGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSI----ALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCtIWVLKALPS 197
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLFLLGALPALLV-LFIRRFVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 198 LP-------GESTSAQQNMFGLLKRPGVMAGMCAIFMAFAGQ---FAFFTYIRPVYMTLA-GFDVDGLTLVLLSFGIASF 266
Cdd:cd17371 180 PPqwqaaraARRHFADRPSLRELFSPPLLRTTLLASLLATGAlggYYGITTWLPSYLTGErGLSFEGSAGYLVVTILGGF 259
|
250
....*....|..
gi 503993318 267 VGTSLSSMLLKR 278
Cdd:cd17371 260 LGYLAGGFLADR 271
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
46-194 |
8.89e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.07 E-value: 8.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 46 MAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGF 125
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503993318 126 WAMSASLTMRLVPMRvVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVLKA 194
Cdd:COG0738 317 FPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
85-325 |
9.31e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.18 E-value: 9.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 85 RYVVILFSVLL-TLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPL 163
Cdd:PRK11551 79 RKRILIVSVALfGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVI 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 164 GSFLGGIIGWRNVFngaAVMGVVCTIWVLKALPSLPgESTSAQQNMFGLLKRPGVMAGMC---------AIFMAFagqfa 234
Cdd:PRK11551 159 GVLAAGDAAWRHIF---YVGGVGPLLLVPLLMRWLP-ESRAFAQAAGAGKQRAPVLRALFgegratatlLLWISY----- 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 235 FFTYI--------RPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKRsVKAALAVAPVVLAISAAVLVLWGESKI 306
Cdd:PRK11551 230 FFTLIvlyfllnwLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDR-LRPRRVVLLIYAGILASLAALAAAPSF 308
|
250
....*....|....*....
gi 503993318 307 VASTVAviwGFAFALIPVG 325
Cdd:PRK11551 309 AGMLLA---GFAAGLFVVG 324
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
42-327 |
1.26e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 42 LLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLgraCLGLA 121
Cdd:cd17352 25 LFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYL---TYGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 122 LGGFWAMSASLTMRLVPMRVVPK---ALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFngaAVMGVVCTIWVLKALpsl 198
Cdd:cd17352 102 GGLGLGLIYSPAIVIVGQYFEKKrglATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL---LILGGLCLNLCVCGL--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 199 pgestsaqqnMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKR 278
Cdd:cd17352 176 ----------LLRLLKDPTFVLLALGVSFAMLGFFVPFVYL-PSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 503993318 279 SVKAALAVAPVVLAISAAVLVLWGESKIVAS--TVAVIWGFAFALIPVGWS 327
Cdd:cd17352 245 PRIGRLYLYIFTLLILGLSLLAFPLATTYVGliVFSVLFGFCSGSYSSLTP 295
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
87-196 |
1.36e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 87 VVILFSVLL-TLSCLLVSFA--NSFALLLLGRACLGLALG-GFWAMsASLTMRLVPMRVVPKALSVIFGAVSIALVIAAP 162
Cdd:cd17380 65 KVLLLAVALwSLATLLTPLLaySSLPLLILSRILLGLGEGvHFPSM-TSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGL 143
|
90 100 110
....*....|....*....|....*....|....*
gi 503993318 163 LGSFLGGIIGWRNVFNGAAVMGVV-CTIWVLKALP 196
Cdd:cd17380 144 IGPLLLEYYGWPSVFYFFGLLGLLwALVWLIYLPP 178
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
47-278 |
1.75e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 43.36 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 47 AQDLGISEGVAgqSVTTTAFVAMFA--SLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRAclglaLGG 124
Cdd:PRK11102 18 AADFGVSAGSV--QMTLSAYILGFAigQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF-----LHG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 125 FWAMSASLT----MR-LVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVLKALP-SL 198
Cdd:PRK11102 91 LAAAAASVVinalMRdMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPeTL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 199 PGES------TSAQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVD------GLTLVLLsfgiasF 266
Cdd:PRK11102 171 PKERrqpfhlRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQnfgyyfALNIVFL------F 244
|
250
....*....|..
gi 503993318 267 VGTSLSSMLLKR 278
Cdd:PRK11102 245 VMTIINSRFVRR 256
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
26-167 |
4.07e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.15 E-value: 4.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 26 AFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRR--YVVILFSVLLTLSCLLVS 103
Cdd:cd17352 189 ALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGrlYLYIFTLLILGLSLLAFP 268
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503993318 104 FANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFL 167
Cdd:cd17352 269 LATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLL 332
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-376 |
4.96e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 4.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 22 VFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLL 101
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 102 VSFANSFALLLLGRACLGLALGGFwAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAA 181
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 182 VMGVVCTIWVLKALPSLpgestsaqqnmFGLLkrpGVMAGMCAIFMAFAGQFAFFTYIRPvymtlaGFDVDGLTLVLLSF 261
Cdd:cd17330 160 ALALLNLVLVLFFLPPL-----------RRLL---LVYFLIALAFAGLESVFSLFLKDRF------GFSPSQIGLLLALV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 262 GIAS-FVGTSLSSMLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPVGWSTWITRSLSDQAE- 339
Cdd:cd17330 220 GIAGiLAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQg 299
|
330 340 350
....*....|....*....|....*....|....*..
gi 503993318 340 KAGSIQVAVIQLANTCGAAVGGVALDHLGLLSPLVLS 376
Cdd:cd17330 300 KAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
90-195 |
5.31e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.87 E-value: 5.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 90 LFSVLLTLSCLLVSfaNSFALLLLgRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGG 169
Cdd:cd17391 278 LASALLYIPQAFVQ--TPWQLGIL-RFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAA 354
|
90 100
....*....|....*....|....*.
gi 503993318 170 IIGWRNVFNGAAVMGVVCTIWVLKAL 195
Cdd:cd17391 355 HFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
59-326 |
5.68e-04 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 41.71 E-value: 5.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 59 QSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVP 138
Cdd:cd17435 40 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 139 MRVVPKALSVIFGAVSIALVIAAPLGSFLGGII-GWRNVFNGAAVMGVVCTIwVLKALPSLPgESTSAQQNMfgllKRPG 217
Cdd:cd17435 120 QHRRGLLVSLNELMIVIGILLAYISNYAFANVSnGWKYMFGLVIPLAALQAI-AMYFLPPSP-RFLVMKDNM----RARL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 218 VMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLL-KRSVKAALAVAPVVLAISAA 296
Cdd:cd17435 194 LIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVdKVGSKTFLCIGSSVMAVSLV 273
|
250 260 270
....*....|....*....|....*....|
gi 503993318 297 VLVLWGEskiVASTVAVIWGFAFALIPVGW 326
Cdd:cd17435 274 TMGLWLS---LASLLVYVAAFSIGLGPMPW 300
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
65-192 |
5.80e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 5.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 65 AFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPK 144
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 503993318 145 ALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVL 192
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
58-196 |
7.03e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.57 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 58 GQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALgGFWAMSASLTM-RL 136
Cdd:cd17362 42 GLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGI-GLAMHAAPVYIaET 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503993318 137 VPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGII-GWRNVFNGAAVMGVV--CTIWVLKALP 196
Cdd:cd17362 121 SPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVgGWRYMYGLAAPPALLlgIGMWFLPPSP 183
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
83-189 |
8.19e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.46 E-value: 8.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 83 DRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGG---FWAMSASLtmrlvpmrVVPKALSVIFGAVSIALVI 159
Cdd:cd06179 60 GRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTqglGAAVASEL--------VPNKYRGLVQGVVNLVASP 131
|
90 100 110
....*....|....*....|....*....|....*.
gi 503993318 160 AAPLGSFLGGII------GWRNVFNGAAVMGVVCTI 189
Cdd:cd06179 132 GSALGPLIAGALveanaaGWRWIFYINAIFNALALI 167
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
49-269 |
8.71e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 41.07 E-value: 8.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 49 DLGISEgVAGQSVTTTAFVAM-FASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWA 127
Cdd:PRK12307 47 DLGLTD-MEGAFLATAAFIGRpFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 128 MSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNgAAVMGVVCTIWVLKALPS--------LP 199
Cdd:PRK12307 126 CASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFF-VGLLPVLLVIYIRARAPEskeweeakLS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 200 GESTSAQQ-------NMFGLLKRPGVMAGMC---AIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFVGT 269
Cdd:PRK12307 205 GKGKHSQSawsvfslSMKGLFNRAQFPLTLCvfiVLFSIFGANWPIFGLL-PTYLAGEGFDTGVVSNLMTAAAFGTVLGN 283
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
47-173 |
9.09e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.29 E-value: 9.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 47 AQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFW 126
Cdd:COG2270 266 AGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQ 345
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 503993318 127 AMSASLTMRLVPmrvvPKALSVIFGAVSIALVIAAPLGSFLGGIIGW 173
Cdd:COG2270 346 ALSRSLLARLIP----PGREAEFFGLYALSGKAASFLGPLLFGLVTQ 388
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
83-322 |
1.33e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 40.24 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 83 DRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAP 162
Cdd:cd17502 58 GRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 163 LGSFLGGIIGWRNVFNGAAVMGVVCTIWVlkalpslpgestsaqqnmfgllkrPGVMAGMCAIFMAFAGQFAFFTYIrPV 242
Cdd:cd17502 138 IGGAFTDHLSWRWCFYINLPIGGLALALL------------------------RTILLSSIFGFLFGGALFGLIYYL-PL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 243 YM-TLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKRS--VKAALAVAPVVLAISAAVL--VLWGESKIVASTVAVIWGF 317
Cdd:cd17502 193 YFqLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTgrYKPLIVIGTILMSVGAGLLttLTLDTSKWLLIGYLILLGL 272
|
....*
gi 503993318 318 AFALI 322
Cdd:cd17502 273 GLGIG 277
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
18-192 |
1.49e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 18 NWSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTL 97
Cdd:cd17370 197 KLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLAL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 98 SCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVF 177
Cdd:cd17370 277 AYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAF 356
|
170
....*....|....*
gi 503993318 178 NGAAVMGVVCTIWVL 192
Cdd:cd17370 357 LFSAVLALIALLLLL 371
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
23-192 |
1.87e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.93 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 23 FAVAFCVAclitveFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLV 102
Cdd:cd17341 8 FFLGFMVW------FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 103 SFA-NSFALLLLGRACLGLALGGFwAMSASLTMRLVPMRVVPKALSVIFGA-------VSIALVIAAPLGSFLGGIIGWR 174
Cdd:cd17341 82 ALAvSSYWGLLVLGFLLGFAGANF-ASGQPWASFWFPKEKIGGAAGGIAGAgnmgvavSQLLAPLIAGAIVFDGGFVGWR 160
|
170
....*....|....*...
gi 503993318 175 NVFNGAAVMGVVCTIWVL 192
Cdd:cd17341 161 NAFFVPGILLAIAAVLVL 178
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
61-326 |
1.94e-03 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 40.17 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 61 VTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMR 140
Cdd:cd17436 42 VSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPH 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 141 VVPKALSVIFGAVSIALVIAAPLGSFLGGII-GWRNVFnGAAVMGVVCTIWVLKALPSLPgESTSAQQNMfgllKRPGVM 219
Cdd:cd17436 122 QRGLLVSLYEAGITVGILISYALNYFFSNVLtGWRYMF-GLAIIPAAIQFASILLLPKKP-EVLNIKDNM----RRRTLV 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 220 AGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKRSVKAALAVAP-VVLAISAAVL 298
Cdd:cd17436 196 GLGLVLFQQFTGQPNVLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGcSVMAVSVSGI 275
|
250 260
....*....|....*....|....*...
gi 503993318 299 VLWgesKIVASTVAVIWGFAFALIPVGW 326
Cdd:cd17436 276 GLW---ITLLCLMAFVSAFSIGFGPMTW 300
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
39-326 |
2.72e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.48 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 39 PVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACL 118
Cdd:cd17315 18 GALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 119 GLALGgfwamsasLTMRLVPM---RVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVL--K 193
Cdd:cd17315 98 GLGVG--------LASVLVPLyisEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVPALlqL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 194 ALPSLPGEStsaqqnmfgllkRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLsfGIASFVGTSLSS 273
Cdd:cd17315 170 LLMFFLPES------------RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAGGGTASILASIIV--GVVNLLATLVAI 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503993318 274 MLLKRS-VKAALAVAPVVLAISAAVLVL---WGESKIVASTVAV------IWGFAFALIPVGW 326
Cdd:cd17315 236 RLVDKVgRRPLLLIGFAGMAASLLLLAIaflLPALAKAAGWLALlgillyIAAFAMGAGPVPW 298
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
46-201 |
2.99e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 39.51 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 46 MAQDLGISEGvAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLL-TLSCLLVSFANSFALLLLGRACLGLALGG 124
Cdd:PRK11652 34 MARDLNVREG-AVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIfILGTLVALFAHSLTVLIAASAIQGLGTGV 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503993318 125 FWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFNGAAVMGVVCTIWVLKALP-SLPGE 201
Cdd:PRK11652 113 GGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPeTRPAD 190
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
40-300 |
3.06e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 40 VSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASL---FITSIIRStdRRYVVILFSVLLTLSCLLVSFANSFALLLLGRA 116
Cdd:cd17490 16 VPFLSPYAESLGASLSMIGIILGAYGISQMLLRIplgILSDRIGK--RKLFIIIGLLFTVLASLIMILFPSPWGLLIARF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 117 CLGLAlGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVF---NGAAVMGVVCTIwVLK 193
Cdd:cd17490 94 LSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFllaALAGVLGFILSL-FIK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 194 ALPSLPGESTSAQQNMFGLLKRPGVM-AGMCAIFMAFAgQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLS 272
Cdd:cd17490 172 EERREKKPVLTELKELLSVLKDKKLLfFSLLAILQQMI-TFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLS 250
|
250 260
....*....|....*....|....*...
gi 503993318 273 SMLLKRSVKAALAVAPVVLAISAAVLVL 300
Cdd:cd17490 251 GTLFYKKLGERNTIIIGFLLLGAYCFLI 278
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-156 |
3.34e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 3.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 3 PSNASTPQAHQAARPNWSAVFAVAFCVACLITVEFLPVSLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRST 82
Cdd:COG2814 191 AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503993318 83 DRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSVIFGAVSIA 156
Cdd:COG2814 271 GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
59-278 |
3.95e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 39.16 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 59 QSVTTTAFVA-MFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRACLGLALGgfwamsasLTMRLV 137
Cdd:cd17361 54 QLFTSSLYLAgLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVG--------FGNQAV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 138 PMRVVPKALSVIFGAVSIALVIAAPLGSFLGGII----------GWRNVFNGAAVMGVVCTIWvlkaLPSLPGESTSAQQ 207
Cdd:cd17361 126 PLYLSEMAPAKLRGALNIGFQLAITIGILIANLInygtskikpnGWRLSLGLAAVPALILLLG----SLFLPETPNSPQL 201
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503993318 208 nmfgllkrpgVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFVGTSLSSMLLKR 278
Cdd:cd17361 202 ----------VIAILIPFFQQLTGINVIMFYA-PVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDR 261
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-324 |
5.81e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 5.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 37 FLPVsLLTPMAQDLGISEGVAGQSVTTTAFVAMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFANSFALLLLGRA 116
Cdd:cd17478 14 FLPA-LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 117 CLGLALGGFWAMSASLTMRLVPMRvVPKALSV--IFGAVSIAL--VIAAPLGSFLGGiIGWRNVFNGAAVMGVVCTIWVL 192
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGR-RGLAMSIfsVGGNLGFALgpLIAAALVALFGG-LGLLILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 193 KALPSLPGESTSAQQNMFGL-LKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFVGTSL 271
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLkGVWRALLLLLIIVFLRSWVLSSLTTFL-PFYLVQRGYSLVFAGLLLSLFLFAGAIGTLI 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 503993318 272 SSMLLKRSVKAALAVAPVVLAISAAVLVLWGESKIVASTVAVIWGFAFALIPV 324
Cdd:cd17478 250 GGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPV 302
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
68-200 |
6.59e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.40 E-value: 6.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993318 68 AMFASLFITSIIRSTDRRYVVILFSVLLTLSCLLVSFAN---SFALLLLGRACLGLALGgfwamsasLTMRLVPMRVVPK 144
Cdd:cd17357 62 GAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKsakSPELLIFGRFLVGIACG--------LSTGFVPMYLQEI 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 503993318 145 ALSVIFGAVSIALVIAAPLGSFLGGIIGWRNVFngaavmGVVCTIWVLKALPSLPG 200
Cdd:cd17357 134 SPSELRGALGSLTQIGVTLGILLGQVFGLPSVL------GTETLWPYLLFFPGIPA 183
|
|
| |
