|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15001 |
PRK15001 |
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG; |
1-384 |
1.86e-110 |
|
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
Pssm-ID: 184963 [Multi-domain] Cd Length: 378 Bit Score: 328.14 E-value: 1.86e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 1 MNRLTTSQGEFDLARYPE-NPRDPLRAWDAADEYLLRRLegeDGSEPvrpSGTVAVVGDRWGALTTALAARRPVQITDSY 79
Cdd:PRK15001 1 MSHLDNGFRSLTLQRFPAtDDVNPLQAWEAADEYLLQQL---DDTEI---RGPVLILNDAFGALSCALAEHKPYSIGDSY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 80 LARQATRANLARNGADPDSVQVL-SVRDTPPARiDLLLVRVPKSLALLEDQLHRLAPAVHAGTVVIGTGMVKEIHTSTLK 158
Cdd:PRK15001 75 ISELATRENLRLNGIDESSVKFLdSTADYPQQP-GVVLIKVPKTLALLEQQLRALRKVVTSDTRIIAGAKARDIHTSTLE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 159 LFERIIGPTRTSLAVKKARLIFST-PDPALPRTPSPWPYRYElpgdvgvLSGRTVTNHAGIFCAERLDIGTRFFLKHLPE 237
Cdd:PRK15001 154 LFEKVLGPTTTTLAWKKARLINCTfNEPPLADAPQTVSWKLE-------GTDWTIHNHANVFSRTGLDIGARFFMQHLPE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 238 RTGPDrVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNTgPDA--EAEFLVGDGTAGVPPASVDLVLS 315
Cdd:PRK15001 227 NLEGE-IVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNM-PEAldRCEFMINNALSGVEPFRFNAVLC 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503923997 316 NPPFHSHQAVTDATARNMFYGARAALRQGGELWVVGNRHLGYHTQLRRIFGNCVTVAGDPKFVVLRAVK 384
Cdd:PRK15001 305 NPPFHQQHALTDNVAWEMFHHARRCLKINGELYIVANRHLDYFHKLKKIFGNCTTIATNNKFVVLKAVK 373
|
|
| RsmC |
COG2813 |
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ... |
191-384 |
2.81e-76 |
|
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 442062 [Multi-domain] Cd Length: 191 Bit Score: 233.93 E-value: 2.81e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 191 PSPWPYRYELPGDVGVLsgrTVTNHAGIFCAERLDIGTRFFLKHLPERTGpDRVVDLGCGNGVVGTAAALANPDASVVFT 270
Cdd:COG2813 4 ASDWPRTITVRLAGRDL---TFVTLPGVFSRDRLDIGTRLLLEHLPEPLG-GRVLDLGCGYGVIGLALAKRNPEARVTLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 271 DESYQAVASAEATFRDNtGPDaEAEFLVGDGTAGVPPASVDLVLSNPPFHSHQAVTDATARNMFYGARAALRQGGELWVV 350
Cdd:COG2813 80 DVNARAVELARANAAAN-GLE-NVEVLWSDGLSGVPDGSFDLILSNPPFHAGRAVDKEVAHALIADAARHLRPGGELWLV 157
|
170 180 190
....*....|....*....|....*....|....
gi 503923997 351 GNRHLGYHTQLRRIFGNCVTVAGDPKFVVLRAVK 384
Cdd:COG2813 158 ANRHLPYERKLEELFGNVEVLARNKGFKVLRAVK 191
|
|
| MTS |
pfam05175 |
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ... |
209-381 |
6.16e-70 |
|
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.
Pssm-ID: 428349 [Multi-domain] Cd Length: 170 Bit Score: 217.07 E-value: 6.16e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 209 GRTVTNHAGIFCAERLDIGTRFFLKHLPERTGpDRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNT 288
Cdd:pfam05175 1 ELTFKTLPGVFSHGRLDIGSRLLLEHLPKDLS-GKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 289 GPDAEaeFLVGDGTAGVPPASVDLVLSNPPFHSHQAVTDATARNMFYGARAALRQGGELWVVGNRHLGYHTQLRRIFGNC 368
Cdd:pfam05175 80 LENGE--VVASDVYSGVEDGKFDLIISNPPFHAGLATTYNVAQRFIADAKRHLRPGGELWIVANRFLGYPPLLEELFGNV 157
|
170
....*....|...
gi 503923997 369 VTVAGDPKFVVLR 381
Cdd:pfam05175 158 EVVAKTNGFKVLK 170
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
243-350 |
6.61e-09 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 53.20 E-value: 6.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 243 RVVDLGCGNGVVgTAAALANPDASVVFTDESyqAVASAEATFRDNTGPDAEAEFLVGDGTAGV--PPASVDLVLSNPPFH 320
Cdd:cd02440 1 RVLDLGCGTGAL-ALALASGPGARVTGVDIS--PVALELARKAAAALLADNVEVLKGDAEELPpeADESFDVIISDPPLH 77
|
90 100 110
....*....|....*....|....*....|
gi 503923997 321 SHQAVTDATARNmfygARAALRQGGELWVV 350
Cdd:cd02440 78 HLVEDLARFLEE----ARRLLKPGGVLVLT 103
|
|
| hemK_fam |
TIGR00536 |
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ... |
235-319 |
1.45e-07 |
|
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]
Pssm-ID: 273125 [Multi-domain] Cd Length: 284 Bit Score: 52.36 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 235 LPERTGPDRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNtGPDAEAEFLVGDGTAGVPPASVDLVL 314
Cdd:TIGR00536 109 LISQPPILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKN-QLEHRVEFIQSNLFEPLAGQKIDIIV 187
|
....*
gi 503923997 315 SNPPF 319
Cdd:TIGR00536 188 SNPPY 192
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15001 |
PRK15001 |
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG; |
1-384 |
1.86e-110 |
|
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
Pssm-ID: 184963 [Multi-domain] Cd Length: 378 Bit Score: 328.14 E-value: 1.86e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 1 MNRLTTSQGEFDLARYPE-NPRDPLRAWDAADEYLLRRLegeDGSEPvrpSGTVAVVGDRWGALTTALAARRPVQITDSY 79
Cdd:PRK15001 1 MSHLDNGFRSLTLQRFPAtDDVNPLQAWEAADEYLLQQL---DDTEI---RGPVLILNDAFGALSCALAEHKPYSIGDSY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 80 LARQATRANLARNGADPDSVQVL-SVRDTPPARiDLLLVRVPKSLALLEDQLHRLAPAVHAGTVVIGTGMVKEIHTSTLK 158
Cdd:PRK15001 75 ISELATRENLRLNGIDESSVKFLdSTADYPQQP-GVVLIKVPKTLALLEQQLRALRKVVTSDTRIIAGAKARDIHTSTLE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 159 LFERIIGPTRTSLAVKKARLIFST-PDPALPRTPSPWPYRYElpgdvgvLSGRTVTNHAGIFCAERLDIGTRFFLKHLPE 237
Cdd:PRK15001 154 LFEKVLGPTTTTLAWKKARLINCTfNEPPLADAPQTVSWKLE-------GTDWTIHNHANVFSRTGLDIGARFFMQHLPE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 238 RTGPDrVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNTgPDA--EAEFLVGDGTAGVPPASVDLVLS 315
Cdd:PRK15001 227 NLEGE-IVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNM-PEAldRCEFMINNALSGVEPFRFNAVLC 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503923997 316 NPPFHSHQAVTDATARNMFYGARAALRQGGELWVVGNRHLGYHTQLRRIFGNCVTVAGDPKFVVLRAVK 384
Cdd:PRK15001 305 NPPFHQQHALTDNVAWEMFHHARRCLKINGELYIVANRHLDYFHKLKKIFGNCTTIATNNKFVVLKAVK 373
|
|
| RsmC |
COG2813 |
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ... |
191-384 |
2.81e-76 |
|
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 442062 [Multi-domain] Cd Length: 191 Bit Score: 233.93 E-value: 2.81e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 191 PSPWPYRYELPGDVGVLsgrTVTNHAGIFCAERLDIGTRFFLKHLPERTGpDRVVDLGCGNGVVGTAAALANPDASVVFT 270
Cdd:COG2813 4 ASDWPRTITVRLAGRDL---TFVTLPGVFSRDRLDIGTRLLLEHLPEPLG-GRVLDLGCGYGVIGLALAKRNPEARVTLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 271 DESYQAVASAEATFRDNtGPDaEAEFLVGDGTAGVPPASVDLVLSNPPFHSHQAVTDATARNMFYGARAALRQGGELWVV 350
Cdd:COG2813 80 DVNARAVELARANAAAN-GLE-NVEVLWSDGLSGVPDGSFDLILSNPPFHAGRAVDKEVAHALIADAARHLRPGGELWLV 157
|
170 180 190
....*....|....*....|....*....|....
gi 503923997 351 GNRHLGYHTQLRRIFGNCVTVAGDPKFVVLRAVK 384
Cdd:COG2813 158 ANRHLPYERKLEELFGNVEVLARNKGFKVLRAVK 191
|
|
| MTS |
pfam05175 |
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ... |
209-381 |
6.16e-70 |
|
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.
Pssm-ID: 428349 [Multi-domain] Cd Length: 170 Bit Score: 217.07 E-value: 6.16e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 209 GRTVTNHAGIFCAERLDIGTRFFLKHLPERTGpDRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNT 288
Cdd:pfam05175 1 ELTFKTLPGVFSHGRLDIGSRLLLEHLPKDLS-GKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 289 GPDAEaeFLVGDGTAGVPPASVDLVLSNPPFHSHQAVTDATARNMFYGARAALRQGGELWVVGNRHLGYHTQLRRIFGNC 368
Cdd:pfam05175 80 LENGE--VVASDVYSGVEDGKFDLIISNPPFHAGLATTYNVAQRFIADAKRHLRPGGELWIVANRFLGYPPLLEELFGNV 157
|
170
....*....|...
gi 503923997 369 VTVAGDPKFVVLR 381
Cdd:pfam05175 158 EVVAKTNGFKVLK 170
|
|
| rsmC |
PRK09489 |
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC; |
217-383 |
2.61e-22 |
|
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
Pssm-ID: 181902 [Multi-domain] Cd Length: 342 Bit Score: 96.55 E-value: 2.61e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 217 GIFCAERLDIGTRFFLKHLPERTGPDrVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNtgpDAEAEF 296
Cdd:PRK09489 174 GVFSRDGLDVGSQLLLSTLTPHTKGK-VLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAAN---GLEGEV 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 297 LVGDGTAGVpPASVDLVLSNPPFH-----SHQAVTDatarnMFYGARAALRQGGELWVVGNRHLGYHTQLRRIFGNCVTV 371
Cdd:PRK09489 250 FASNVFSDI-KGRFDMIISNPPFHdgiqtSLDAAQT-----LIRGAVRHLNSGGELRIVANAFLPYPDLLDETFGSHEVL 323
|
170
....*....|..
gi 503923997 372 AGDPKFVVLRAV 383
Cdd:PRK09489 324 AQTGRFKVYRAI 335
|
|
| HemK |
COG2890 |
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ... |
232-318 |
1.66e-12 |
|
Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442135 [Multi-domain] Cd Length: 282 Bit Score: 67.10 E-value: 1.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 232 LKHLPERTGPdRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNtGPDAEAEFLVGDGTAGVPPA-SV 310
Cdd:COG2890 105 LALLPAGAPP-RVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERL-GLEDRVRFLQGDLFEPLPGDgRF 182
|
....*...
gi 503923997 311 DLVLSNPP 318
Cdd:COG2890 183 DLIVSNPP 190
|
|
| PRK09328 |
PRK09328 |
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional |
232-318 |
7.59e-12 |
|
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
Pssm-ID: 236467 [Multi-domain] Cd Length: 275 Bit Score: 65.18 E-value: 7.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 232 LKHLPERTGPdRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNTGpdAEAEFLVGDGTAGVPPASVD 311
Cdd:PRK09328 101 LEALLLKEPL-RVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLG--ARVEFLQGDWFEPLPGGRFD 177
|
....*..
gi 503923997 312 LVLSNPP 318
Cdd:PRK09328 178 LIVSNPP 184
|
|
| COG2263 |
COG2263 |
Predicted RNA methylase [General function prediction only]; |
242-319 |
4.84e-11 |
|
Predicted RNA methylase [General function prediction only];
Pssm-ID: 441864 [Multi-domain] Cd Length: 199 Bit Score: 61.46 E-value: 4.84e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503923997 242 DRVVDLGCGNGVVGTAAALANPdASVVFTDESYQAVASAEATFRDNTGPdaeAEFLVGDGTAGVPPASVDLVLSNPPF 319
Cdd:COG2263 47 KTVLDLGCGTGMLAIGAALLGA-KKVVGVDIDPEALEIARENAERLGVR---VDFIRADVTRIPLGGSVDTVVMNPPF 120
|
|
| TrmN6 |
COG4123 |
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ... |
241-350 |
4.38e-10 |
|
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 59.39 E-value: 4.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 241 PDRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNtGPDAEAEFLVGD---GTAGVPPASVDLVLSNP 317
Cdd:COG4123 38 GGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALN-GLEDRITVIHGDlkeFAAELPPGSFDLVVSNP 116
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 503923997 318 PFHSHQAVTD------ATARNM--------FYGARAALRQGGELWVV 350
Cdd:COG4123 117 PYFKAGSGRKspdearAIARHEdaltledlIRAAARLLKPGGRFALI 163
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
244-345 |
4.51e-10 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 56.03 E-value: 4.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 244 VVDLGCGNGVVgTAAALANPDASVVFTDESYQAVASAEATFRDNtgpDAEAEFLVGDGTA-GVPPASVDLVLSNPPFHsh 322
Cdd:pfam13649 1 VLDLGCGTGRL-TLALARRGGARVTGVDLSPEMLERARERAAEA---GLNVEFVQGDAEDlPFPDGSFDLVVSSGVLH-- 74
|
90 100
....*....|....*....|...
gi 503923997 323 qAVTDATARNMFYGARAALRQGG 345
Cdd:pfam13649 75 -HLPDPDLEAALREIARVLKPGG 96
|
|
| Tam |
COG4106 |
Trans-aconitate methyltransferase [Energy production and conversion]; |
240-347 |
9.79e-10 |
|
Trans-aconitate methyltransferase [Energy production and conversion];
Pssm-ID: 443282 [Multi-domain] Cd Length: 100 Bit Score: 55.21 E-value: 9.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 240 GPDRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFrdntgpdAEAEFLVGDGTAGVPPASVDLVLSNppf 319
Cdd:COG4106 1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL-------PNVRFVVADLRDLDPPEPFDLVVSN--- 70
|
90 100
....*....|....*....|....*...
gi 503923997 320 HSHQAVTDATArnMFYGARAALRQGGEL 347
Cdd:COG4106 71 AALHWLPDHAA--LLARLAAALAPGGVL 96
|
|
| UbiE |
COG2226 |
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
229-350 |
1.93e-09 |
|
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 55.77 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 229 RFFLKHLPERTGpDRVVDLGCGNGvvGTAAALANPDASVVFTDESYQAVASAEATFRDNtgpDAEAEFLVGDGTA-GVPP 307
Cdd:COG2226 12 EALLAALGLRPG-ARVLDLGCGTG--RLALALAERGARVTGVDISPEMLELARERAAEA---GLNVEFVVGDAEDlPFPD 85
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 503923997 308 ASVDLVLSNppfHSHQAVTDATArnMFYGARAALRQGGELWVV 350
Cdd:COG2226 86 GSFDLVISS---FVLHHLPDPER--ALAEIARVLKPGGRLVVV 123
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
243-350 |
6.61e-09 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 53.20 E-value: 6.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 243 RVVDLGCGNGVVgTAAALANPDASVVFTDESyqAVASAEATFRDNTGPDAEAEFLVGDGTAGV--PPASVDLVLSNPPFH 320
Cdd:cd02440 1 RVLDLGCGTGAL-ALALASGPGARVTGVDIS--PVALELARKAAAALLADNVEVLKGDAEELPpeADESFDVIISDPPLH 77
|
90 100 110
....*....|....*....|....*....|
gi 503923997 321 SHQAVTDATARNmfygARAALRQGGELWVV 350
Cdd:cd02440 78 HLVEDLARFLEE----ARRLLKPGGVLVLT 103
|
|
| Methyltransf_12 |
pfam08242 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
245-347 |
1.88e-08 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 400515 [Multi-domain] Cd Length: 98 Bit Score: 51.60 E-value: 1.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 245 VDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNTGPDAEAEFLVGDGTAGVPPASVDLVLSNPPFHsHQA 324
Cdd:pfam08242 1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVVASNVLH-HLA 79
|
90 100
....*....|....*....|...
gi 503923997 325 VTDATARNMfygaRAALRQGGEL 347
Cdd:pfam08242 80 DPRAVLRNI----RRLLKPGGVL 98
|
|
| hemK_fam |
TIGR00536 |
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ... |
235-319 |
1.45e-07 |
|
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]
Pssm-ID: 273125 [Multi-domain] Cd Length: 284 Bit Score: 52.36 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 235 LPERTGPDRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDNtGPDAEAEFLVGDGTAGVPPASVDLVL 314
Cdd:TIGR00536 109 LISQPPILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKN-QLEHRVEFIQSNLFEPLAGQKIDIIV 187
|
....*
gi 503923997 315 SNPPF 319
Cdd:TIGR00536 188 SNPPY 192
|
|
| PRK14968 |
PRK14968 |
putative methyltransferase; Provisional |
242-319 |
3.03e-07 |
|
putative methyltransferase; Provisional
Pssm-ID: 237872 [Multi-domain] Cd Length: 188 Bit Score: 50.28 E-value: 3.03e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503923997 242 DRVVDLGCGNGVVgtAAALANPDASVVFTDESYQAVASAEATFRDNTGPDAEAEFLVGDGTAGVPPASVDLVLSNPPF 319
Cdd:PRK14968 25 DRVLEVGTGSGIV--AIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNGVEVIRSDLFEPFRGDKFDVILFNPPY 100
|
|
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
228-349 |
1.25e-06 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 47.32 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 228 TRFFLKHLPErtgPDRVVDLGCGNGvvGTAAALANPDASVVFTDESYQAVASAEAtfrdnTGPDAEAEFLVGDGTA-GVP 306
Cdd:COG2227 15 AALLARLLPA---GGRVLDVGCGTG--RLALALARRGADVTGVDISPEALEIARE-----RAAELNVDFVQGDLEDlPLE 84
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 503923997 307 PASVDLVLSNppfHSHQAVTDatARNMFYGARAALRQGGELWV 349
Cdd:COG2227 85 DGSFDLVICS---EVLEHLPD--PAALLRELARLLKPGGLLLL 122
|
|
| SmtA |
COG0500 |
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
219-358 |
2.56e-06 |
|
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];
Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 47.60 E-value: 2.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 219 FCAERLDIGTRFFLKHLPERTGPDRVVDLGCGNGvvGTAAALANPDAS-VVFTDESYQAVASAEATFRDNTgpDAEAEFL 297
Cdd:COG0500 5 YYSDELLPGLAALLALLERLPKGGRVLDLGCGTG--RNLLALAARFGGrVIGIDLSPEAIALARARAAKAG--LGNVEFL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503923997 298 VGD--GTAGVPPASVDLVLSNPPFHSHQ-AVTDATARNMfygaRAALRQGGELWVVGNRHLGYH 358
Cdd:COG0500 81 VADlaELDPLPAESFDLVVAFGVLHHLPpEEREALLREL----ARALKPGGVLLLSASDAAAAL 140
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
229-345 |
2.12e-05 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 44.15 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 229 RFFLKHLPERTGpDRVVDLGCGNGvvGTAAALA-NPDASVVFTDESYQAVASAEATFRDnTGPDAEAEFLVGDGTAGVPP 307
Cdd:COG2230 41 DLILRKLGLKPG-MRVLDIGCGWG--GLALYLArRYGVRVTGVTLSPEQLEYARERAAE-AGLADRVEVRLADYRDLPAD 116
|
90 100 110
....*....|....*....|....*....|....*...
gi 503923997 308 ASVDLVLSNPPFHshqAVTDATARNMFYGARAALRQGG 345
Cdd:COG2230 117 GQFDAIVSIGMFE---HVGPENYPAYFAKVARLLKPGG 151
|
|
| PRK14967 |
PRK14967 |
putative methyltransferase; Provisional |
243-319 |
2.84e-05 |
|
putative methyltransferase; Provisional
Pssm-ID: 184931 [Multi-domain] Cd Length: 223 Bit Score: 45.04 E-value: 2.84e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503923997 243 RVVDLGCGNGVVGTAAALANPdASVVFTDESYQAVASAeatFRDNTGPDAEAEFLVGDGTAGVPPASVDLVLSNPPF 319
Cdd:PRK14967 39 RVLDLCTGSGALAVAAAAAGA-GSVTAVDISRRAVRSA---RLNALLAGVDVDVRRGDWARAVEFRPFDVVVSNPPY 111
|
|
| Methyltransf_31 |
pfam13847 |
Methyltransferase domain; This family appears to have methyltransferase activity. |
243-347 |
5.88e-05 |
|
Methyltransferase domain; This family appears to have methyltransferase activity.
Pssm-ID: 463998 [Multi-domain] Cd Length: 150 Bit Score: 42.79 E-value: 5.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 243 RVVDLGCGNGVVGTAAA-LANPDASVVFTDESYQAVASAEATFRDNtGPDaEAEFLVGDGTA---GVPPASVDLVLSNPP 318
Cdd:pfam13847 6 RVLDLGCGTGHLSFELAeELGPNAEVVGIDISEEAIEKARENAQKL-GFD-NVEFEQGDIEElpeLLEDDKFDVVISNCV 83
|
90 100
....*....|....*....|....*....
gi 503923997 319 FHsHQAVTDATARNMFygarAALRQGGEL 347
Cdd:pfam13847 84 LN-HIPDPDKVLQEIL----RVLKPGGRL 107
|
|
| PrmA |
COG2264 |
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis]; |
220-316 |
4.03e-04 |
|
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441865 [Multi-domain] Cd Length: 284 Bit Score: 41.70 E-value: 4.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 220 CAERLDigtrfflKHLPERtgpDRVVDLGCGNGVVGTAAAL--ANPdasVVFTDESYQAVASAEATFRDNtGPDAEAEFL 297
Cdd:COG2264 138 CLEALE-------KLLKPG---KTVLDVGCGSGILAIAAAKlgAKR---VLAVDIDPVAVEAARENAELN-GVEDRIEVV 203
|
90
....*....|....*....
gi 503923997 298 VGDgtaGVPPASVDLVLSN 316
Cdd:COG2264 204 LGD---LLEDGPYDLVVAN 219
|
|
| COG4976 |
COG4976 |
Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
229-345 |
6.82e-04 |
|
Predicted methyltransferase, contains TPR repeat [General function prediction only];
Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 40.37 E-value: 6.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 229 RFFLKHLPERTGpdRVVDLGCGNGVVGtaAALANPDASVVFTDESYQAVASAEATFrdntgpdAEAEFLVGD-GTAGVPP 307
Cdd:COG4976 37 ELLARLPPGPFG--RVLDLGCGTGLLG--EALRPRGYRLTGVDLSEEMLAKAREKG-------VYDRLLVADlADLAEPD 105
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 503923997 308 ASVDLVLSN---PPFHSHQAVtdatarnmFYGARAALRQGG 345
Cdd:COG4976 106 GRFDLIVAAdvlTYLGDLAAV--------FAGVARALKPGG 138
|
|
| PrmA |
pfam06325 |
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ... |
240-316 |
7.64e-04 |
|
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.
Pssm-ID: 428888 [Multi-domain] Cd Length: 294 Bit Score: 41.10 E-value: 7.64e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503923997 240 GPDRVVDLGCGNGVVGTAAALANPdASVVFTDESYQAVASAEATFRDNTGPDAEAEFLVGDGtagvPPASVDLVLSN 316
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGA-KKVVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDL----PKEKADVVVAN 232
|
|
| Methyltransf_11 |
pfam08241 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
245-349 |
1.06e-03 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 462406 [Multi-domain] Cd Length: 94 Bit Score: 38.03 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 245 VDLGCGNGVVgtAAALANPDASVVFTDESYQAVASAEAtfrdnTGPDAEAEFLVGDGTA-GVPPASVDLVLSNPPFHsHQ 323
Cdd:pfam08241 1 LDVGCGTGLL--TELLARLGARVTGVDISPEMLELARE-----KAPREGLTFVVGDAEDlPFPDNSFDLVLSSEVLH-HV 72
|
90 100
....*....|....*....|....*.
gi 503923997 324 AVTDATARNMfygARaALRQGGELWV 349
Cdd:pfam08241 73 EDPERALREI---AR-VLKPGGILII 94
|
|
| TrmA |
COG2265 |
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ... |
239-318 |
1.23e-03 |
|
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 441866 [Multi-domain] Cd Length: 377 Bit Score: 40.54 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 239 TGPDRVVDLGCGngvVGT-AAALANPDASVVFTDESYQAVASAEATFRDNTGPDaeAEFLVGDGTAGVP----PASVDLV 313
Cdd:COG2265 232 TGGERVLDLYCG---VGTfALPLARRAKKVIGVEIVPEAVEDARENARLNGLKN--VEFVAGDLEEVLPellwGGRPDVV 306
|
....*
gi 503923997 314 LSNPP 318
Cdd:COG2265 307 VLDPP 311
|
|
| PRK14103 |
PRK14103 |
trans-aconitate 2-methyltransferase; Provisional |
232-320 |
1.53e-03 |
|
trans-aconitate 2-methyltransferase; Provisional
Pssm-ID: 184509 Cd Length: 255 Bit Score: 39.67 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 232 LKHLPERTGPdRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDntgpdaeaeFLVGDGTAGVPPASVD 311
Cdd:PRK14103 22 LARVGAERAR-RVVDLGCGPGNLTRYLARRWPGAVIEALDSSPEMVAAARERGVD---------ARTGDVRDWKPKPDTD 91
|
....*....
gi 503923997 312 LVLSNPPFH 320
Cdd:PRK14103 92 VVVSNAALQ 100
|
|
| Methyltransf_16 |
pfam10294 |
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ... |
230-271 |
1.87e-03 |
|
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.
Pssm-ID: 313513 Cd Length: 172 Bit Score: 38.85 E-value: 1.87e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 503923997 230 FFLKHLPERTGPDR-----VVDLGCGNGVVGTAAALANPDASVVFTD 271
Cdd:pfam10294 31 YLEMKIFKELGANNlsglnVLELGSGTGLVGIAVALLLPGASVTITD 77
|
|
| TrmR |
COG4122 |
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ... |
231-314 |
5.53e-03 |
|
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443298 Cd Length: 173 Bit Score: 37.47 E-value: 5.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 231 FLKHLPERTGPDRVVDLGCGNGVVGTAAALANPDASVVFT---DESYQAVasAEATFRDnTGPDAEAEFLVGDGT---AG 304
Cdd:COG4122 7 LLYLLARLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTieiDPERAAI--ARENFAR-AGLADRIRLILGDALevlPR 83
|
90
....*....|
gi 503923997 305 VPPASVDLVL 314
Cdd:COG4122 84 LADGPFDLVF 93
|
|
| PRK14966 |
PRK14966 |
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ... |
232-319 |
5.63e-03 |
|
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional
Pssm-ID: 184930 [Multi-domain] Cd Length: 423 Bit Score: 38.52 E-value: 5.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 232 LKHLPERtgpDRVVDLGCGNGVVGTAAALANPDASVVFTDESYQAVASAEATFRDntgPDAEAEFLVGDGTAGVPPAS-- 309
Cdd:PRK14966 246 LARLPEN---GRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAAD---LGARVEFAHGSWFDTDMPSEgk 319
|
90
....*....|
gi 503923997 310 VDLVLSNPPF 319
Cdd:PRK14966 320 WDIIVSNPPY 329
|
|
| rumB |
PRK03522 |
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC; |
240-318 |
6.78e-03 |
|
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
Pssm-ID: 235128 [Multi-domain] Cd Length: 315 Bit Score: 37.93 E-value: 6.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503923997 240 GPDRVVDLGCGNGvvGTAAALANPDASVVFTDESYQAVASAEATFRDNTGPDaeAEFLVGDGTA------GVPpasvDLV 313
Cdd:PRK03522 173 PPRSMWDLFCGVG--GFGLHCATPGMQLTGIEISAEAIACAKQSAAELGLTN--VQFQALDSTQfataqgEVP----DLV 244
|
....*
gi 503923997 314 LSNPP 318
Cdd:PRK03522 245 LVNPP 249
|
|
| |
