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Conserved domains on  [gi|503861473|ref|WP_014095467|]
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MULTISPECIES: succinate--CoA ligase subunit alpha [Heyndrickxia]

Protein Classification

succinate--CoA ligase subunit alpha( domain architecture ID 11481473)

ADP-forming/GDP-forming succinate--CoA ligase subunit alpha is the coenzyme A and phosphate binding subunit of the succinyl-CoA synthetase that couples the hydrolysis of succinyl-CoA to the synthesis of ATP/GTP, as part of the citric acid cycle (TCA)

CATH:  3.40.50.261
EC:  6.2.1.-
Gene Ontology:  GO:0000166|GO:0016874|GO:0003824
SCOP:  4000071

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-291 0e+00

succinyl-CoA synthetase subunit alpha; Validated


:

Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 564.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   1 MSIYVNKDTKVIVQGITGKTALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAAD 80
Cdd:PRK05678   1 MSILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  81 AIMEAVDAELDLVICITEHIPVLDMVKVKRYMEGKKTRLIGPNCPGIITPDECKIGIMPGYIHKKGHVGVVSRSGTLTYE 160
Cdd:PRK05678  81 AILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 161 AVHQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIGGTAEEEAAKWVQANMKKPVVGFIGGVTAP 240
Cdd:PRK05678 161 AVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVTKPVVGYIAGVTAP 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 503861473 241 PGKRMGHAGAIISGGKGTAAEKIRTMNECGIQVAETPAVIGETLVRVLKER 291
Cdd:PRK05678 241 PGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLKGL 291
 
Name Accession Description Interval E-value
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-291 0e+00

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 564.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   1 MSIYVNKDTKVIVQGITGKTALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAAD 80
Cdd:PRK05678   1 MSILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  81 AIMEAVDAELDLVICITEHIPVLDMVKVKRYMEGKKTRLIGPNCPGIITPDECKIGIMPGYIHKKGHVGVVSRSGTLTYE 160
Cdd:PRK05678  81 AILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 161 AVHQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIGGTAEEEAAKWVQANMKKPVVGFIGGVTAP 240
Cdd:PRK05678 161 AVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVTKPVVGYIAGVTAP 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 503861473 241 PGKRMGHAGAIISGGKGTAAEKIRTMNECGIQVAETPAVIGETLVRVLKER 291
Cdd:PRK05678 241 PGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLKGL 291
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-289 0e+00

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 556.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   2 SIYVNKDTKVIVQGITGKTALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAADA 81
Cdd:COG0074    1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  82 IMEAVDAELDLVICITEHIPVLDMVKVKRYMEGKKTRLIGPNCPGIITPDECKIGIMPGYIHKKGHVGVVSRSGTLTYEA 161
Cdd:COG0074   81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 162 VHQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIGGTAEEEAAKWVQANMKKPVVGFIGGVTAPP 241
Cdd:COG0074  161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMTKPVVAYIAGRTAPP 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 503861473 242 GKRMGHAGAIISGGKGTAAEKIRTMNECGIQVAETPAVIGETLVRVLK 289
Cdd:COG0074  241 GKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKALK 288
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-288 0e+00

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 506.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473    3 IYVNKDTKVIVQGITGKTALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAADAI 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   83 MEAVDAELDLVICITEHIPVLDMVKVKRYMEGKKTRLIGPNCPGIITPDECKIGIMPGYIHKKGHVGVVSRSGTLTYEAV 162
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  163 HQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIGGTAEEEAAKWVQANMKKPVVGFIGGVTAPPG 242
Cdd:TIGR01019 161 HQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMSKPVVGFIAGATAPPG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 503861473  243 KRMGHAGAIISGGKGTAAEKIRTMNECGIQVAETPAVIGETLVRVL 288
Cdd:TIGR01019 241 KRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-99 1.29e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 118.46  E-value: 1.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473    6 NKDTKVIVQGITGKT---ALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAADAI 82
Cdd:pfam02629   1 DKDTKVIVIGAGGLGiqgLNYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 503861473   83 MEAVDAELDLVICITEH 99
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 5-100 6.46e-31

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 111.45  E-value: 6.46e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473     5 VNKDTKVIVQGITGKTALFHTKQC---LEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAADA 81
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 503861473    82 IMEAVDAELDLVICITEHI 100
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-291 0e+00

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 564.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   1 MSIYVNKDTKVIVQGITGKTALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAAD 80
Cdd:PRK05678   1 MSILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  81 AIMEAVDAELDLVICITEHIPVLDMVKVKRYMEGKKTRLIGPNCPGIITPDECKIGIMPGYIHKKGHVGVVSRSGTLTYE 160
Cdd:PRK05678  81 AILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 161 AVHQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIGGTAEEEAAKWVQANMKKPVVGFIGGVTAP 240
Cdd:PRK05678 161 AVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVTKPVVGYIAGVTAP 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 503861473 241 PGKRMGHAGAIISGGKGTAAEKIRTMNECGIQVAETPAVIGETLVRVLKER 291
Cdd:PRK05678 241 PGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLKGL 291
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-289 0e+00

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 556.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   2 SIYVNKDTKVIVQGITGKTALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAADA 81
Cdd:COG0074    1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  82 IMEAVDAELDLVICITEHIPVLDMVKVKRYMEGKKTRLIGPNCPGIITPDECKIGIMPGYIHKKGHVGVVSRSGTLTYEA 161
Cdd:COG0074   81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 162 VHQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIGGTAEEEAAKWVQANMKKPVVGFIGGVTAPP 241
Cdd:COG0074  161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMTKPVVAYIAGRTAPP 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 503861473 242 GKRMGHAGAIISGGKGTAAEKIRTMNECGIQVAETPAVIGETLVRVLK 289
Cdd:COG0074  241 GKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKALK 288
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-288 0e+00

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 506.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473    3 IYVNKDTKVIVQGITGKTALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAADAI 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   83 MEAVDAELDLVICITEHIPVLDMVKVKRYMEGKKTRLIGPNCPGIITPDECKIGIMPGYIHKKGHVGVVSRSGTLTYEAV 162
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  163 HQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIGGTAEEEAAKWVQANMKKPVVGFIGGVTAPPG 242
Cdd:TIGR01019 161 HQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMSKPVVGFIAGATAPPG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 503861473  243 KRMGHAGAIISGGKGTAAEKIRTMNECGIQVAETPAVIGETLVRVL 288
Cdd:TIGR01019 241 KRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 3-292 1.34e-167

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 467.27  E-value: 1.34e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   3 IYVNKDTKVIVQGITGKTALFHTKQCLEYGTKIVGGTSPGKGGT--EVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAAD 80
Cdd:PTZ00187  24 VWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTthLKHGLPVFATVKEAKKATGADASVIYVPPPHAAS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  81 AIMEAVDAELDLVICITEHIPVLDMVKVKRYME-GKKTRLIGPNCPGIITPDECKIGIMPGYIHKKGHVGVVSRSGTLTY 159
Cdd:PTZ00187 104 AIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLsQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVSRSGTLTY 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 160 EAVHQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIGGTAEEEAAKWVQAN-MKKPVVGFIGGVT 238
Cdd:PTZ00187 184 EAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNNpIKKPVVSFIAGIT 263

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 503861473 239 APPGKRMGHAGAIISGGKGTAAEKIRTMNECGIQVAETPAVIGETLVRVLKERG 292
Cdd:PTZ00187 264 APPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 2-293 8.47e-147

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 414.36  E-value: 8.47e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   2 SIYVNKDTKVIVQGITGKTALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAADA 81
Cdd:PLN00125   6 AVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPPFAAAA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  82 IMEAVDAELDLVICITEHIPVLDMVKVKRYMEGK-KTRLIGPNCPGIITPDECKIGIMPGYIHKKGHVGVVSRSGTLTYE 160
Cdd:PLN00125  86 ILEAMEAELDLVVCITEGIPQHDMVRVKAALNRQsKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGTLTYE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 161 AVHQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIGGTAEEEAAKWVQAN-MKKPVVGFIGGVTA 239
Cdd:PLN00125 166 AVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIKESgTEKPVVAFIAGLTA 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 503861473 240 PPGKRMGHAGAIISGGKGTAAEKIRTMNECGIQVAETPAVIGETLVRVLKERGL 293
Cdd:PLN00125 246 PPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIGVAMLEVFKERGL 299
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-99 1.29e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 118.46  E-value: 1.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473    6 NKDTKVIVQGITGKT---ALFHTKQCLEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAADAI 82
Cdd:pfam02629   1 DKDTKVIVIGAGGLGiqgLNYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 503861473   83 MEAVDAELDLVICITEH 99
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 5-100 6.46e-31

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 111.45  E-value: 6.46e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473     5 VNKDTKVIVQGITGKTALFHTKQC---LEYGTKIVGGTSPGKGGTEVEGVPVFNTVKEAVEKTGATVSVIYVPAPFAADA 81
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 503861473    82 IMEAVDAELDLVICITEHI 100
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 151-262 5.09e-27

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 102.34  E-value: 5.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  151 VSRSGTLTYEAVHQLTRAGIGQTGAIGIGGDPVNGTNFIDVLKEFNNDPETEAVIMIGEIG-GTAEEEAAKWVQA----- 224
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGyGACEDPAGGLLKAikear 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 503861473  225 NMKKPVVGFIGGVTAPPGKRMGHAGAIISGGKGTAAEK 262
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSN 118
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 45-290 1.45e-24

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 103.36  E-value: 1.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  45 GTEVEGVPVFNTVKEAVEKTgATVSVIYVPAPF--AADAIMEAVDAE-LDLVICITEHIPVLDMVKVKRYMEGKKTRLIG 121
Cdd:PLN02522  57 GQEEIAIPVHGSIEAACKAH-PTADVFINFASFrsAAASSMEALKQPtIRVVAIIAEGVPESDTKQLIAYARANNKVVIG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 122 PNCPGIITPDECKIGIMPGYI--------HKKGHVGVVSRSGTLTYEAVHQLTRAGIGQTGAIGIGGDPVNGTNFIDVLK 193
Cdd:PLN02522 136 PATVGGIQAGAFKIGDTAGTLdniiqcklYRPGSVGFVSKSGGMSNEMYNVIARVTDGIYEGIAIGGDVFPGSTLSDHVL 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 194 EFNNDPETEAVIMIGEIGGTAEE---EAAKwvQANMKKPVVGFIGGVTA---PPGKRMGHAGAIISGGKGTAAEKIRTMN 267
Cdd:PLN02522 216 RFNNIPQIKMIVVLGELGGRDEYslvEALK--QGKVSKPVVAWVSGTCArlfKSEVQFGHAGAKSGGDMESAQAKNKALK 293

                        250       260
                 ....*....|....*....|....*..
gi 503861473 268 ECGIQVAET----PAVIGETLVRVLKE 290
Cdd:PLN02522 294 DAGAIVPTSfealEAAIKETFEKLVEE 320
PRK06091 PRK06091
membrane protein FdrA; Validated
 42-239 1.14e-12

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 68.15  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  42 GKGGTEVEGVPVFNTVKEAVEKT-GATVSVIYVPAPFAADAIMEAVDAELDlVICITEHIPVLDMVKVKRYMEGKKTRLI 120
Cdd:PRK06091  93 AQGSGSSQSLTQVRRWDSACQKLpDANLALISVAGEYAAELAEQALDRNLN-VMMFSDNVTLEDEIRLKTRAREKGLLVM 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473 121 GPNC-PGII--TPDECKiGIMPgyihkKGHVGVVSRSGTLTYEAVHQLTRAGIGQTGAIGIGG----DPVNGTNFIDVLK 193
Cdd:PRK06091 172 GPDCgTAMIagTPLAFA-NVMP-----EGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGrdlsAEVGGISALTALE 245

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 503861473 194 EFNNDPETEAVIMIGEigGTAEEEAAKWVQA--NMKKPVVG-FIGGVTA 239
Cdd:PRK06091 246 MLSADEKSEVIAFVSK--PPAEAVRLKIINAmkATGKPVVAlFLGYTPA 292
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 145-251 5.43e-07

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 47.85  E-value: 5.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473  145 KGHVGVVSRSGTLTYEAVHQLTRAGIGQTGAIGIGgdpvNGT--NFIDVLKEFNNDPETEAVIM-IGEIGGTAE-EEAAK 220
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLG----NEAdvDFADLLEYLADDPETRVILLyLEGIRDGRRfLRAAR 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 503861473  221 wvQANMKKPVVGFIGGVTaPPGKRMG--HAGAI 251
Cdd:pfam13607  77 --RAARRKPVVVLKAGRS-EAGARAAasHTGAL 106
PRK05472 PRK05472
redox-sensing transcriptional repressor Rex; Provisional
 5-85 1.06e-05

redox-sensing transcriptional repressor Rex; Provisional


Pssm-ID: 235486 [Multi-domain]  Cd Length: 213  Bit Score: 45.49  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503861473   5 VNKDTKVIVQGItGK--TALFHTKQCLEYGTKIVGG--TSPGKGGTEVEGVPVF--NTVKEAVEKTGATVSVIYVPAPFA 78
Cdd:PRK05472  81 LDRTWNVALVGA-GNlgRALLNYNGFEKRGFKIVAAfdVDPEKIGTKIGGIPVYhiDELEEVVKENDIEIGILTVPAEAA 159

                         90
                 ....*....|
gi 503861473  79 ---ADAIMEA 85
Cdd:PRK05472 160 qevADRLVEA 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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