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Conserved domains on  [gi|503834547|ref|WP_014068541|]
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tetratricopeptide repeat protein [Enterobacter soli]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
15-207 1.13e-21

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 89.60  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  15 AYADEIGNQYKEQAEAGDAHAQYYLADTYFS----SGDSKQATFWAEKAAKGGDIDAMALLSQI----QFTHGDYAHAKA 86
Cdd:COG0790   45 AGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEgrgvPKDYEKALEWFEKAAEQGDAEAQYNLGLMyeegLGVPQDYAKALE 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  87 LAQQATIAGSKRGAIMLARVLVNTQAGKTDYPQAIKLLQTATEDIDsdsaVDAQLLLGLIYANGVEVAQDDAKAASWFKR 166
Cdd:COG0790  125 WYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGD----ADAQYNLGVLYENGRGVPKDPAKALEWYRK 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 503834547 167 SSSLSRtGYAEYWAGMLFQQGEKgfITPNKQKALYWLNLSC 207
Cdd:COG0790  201 AAEQGD-ADAQYNLGRLYLNGEG--VEKDLEKALRWLRKAA 238
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
15-207 1.13e-21

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 89.60  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  15 AYADEIGNQYKEQAEAGDAHAQYYLADTYFS----SGDSKQATFWAEKAAKGGDIDAMALLSQI----QFTHGDYAHAKA 86
Cdd:COG0790   45 AGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEgrgvPKDYEKALEWFEKAAEQGDAEAQYNLGLMyeegLGVPQDYAKALE 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  87 LAQQATIAGSKRGAIMLARVLVNTQAGKTDYPQAIKLLQTATEDIDsdsaVDAQLLLGLIYANGVEVAQDDAKAASWFKR 166
Cdd:COG0790  125 WYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGD----ADAQYNLGVLYENGRGVPKDPAKALEWYRK 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 503834547 167 SSSLSRtGYAEYWAGMLFQQGEKgfITPNKQKALYWLNLSC 207
Cdd:COG0790  201 AAEQGD-ADAQYNLGRLYLNGEG--VEKDLEKALRWLRKAA 238
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 137-170 1.51e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.23  E-value: 1.51e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 503834547   137 VDAQLLLGLIYANGVEVAQDDAKAASWFKRSSSL 170
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAEL 34
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
15-207 1.13e-21

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 89.60  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  15 AYADEIGNQYKEQAEAGDAHAQYYLADTYFS----SGDSKQATFWAEKAAKGGDIDAMALLSQI----QFTHGDYAHAKA 86
Cdd:COG0790   45 AGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEgrgvPKDYEKALEWFEKAAEQGDAEAQYNLGLMyeegLGVPQDYAKALE 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  87 LAQQATIAGSKRGAIMLARVLVNTQAGKTDYPQAIKLLQTATEDIDsdsaVDAQLLLGLIYANGVEVAQDDAKAASWFKR 166
Cdd:COG0790  125 WYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGD----ADAQYNLGVLYENGRGVPKDPAKALEWYRK 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 503834547 167 SSSLSRtGYAEYWAGMLFQQGEKgfITPNKQKALYWLNLSC 207
Cdd:COG0790  201 AAEQGD-ADAQYNLGRLYLNGEG--VEKDLEKALRWLRKAA 238
TPR COG0790
TPR repeat [General function prediction only];
56-215 2.76e-09

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 55.32  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  56 AEKAAKGGDIDAMALLSQIQFTHGDYAHAKALAQQATIAGSKRGAIMLARVLVNTQAGKTDYPQAIKLLQTATEDIDsds 135
Cdd:COG0790   22 AAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGD--- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547 136 aVDAQLLLGLIYANGVEVAQDDAKAASWFKRSSSLSRTgYAEYWAGMLFQQGEkgFITPNKQKALYWLNLSCSEGFDTGC 215
Cdd:COG0790   99 -AEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDA-DAQYNLGLLYLNGE--GVPKDPAKAAEWYRKAAEQGDADAQ 174
TPR COG0790
TPR repeat [General function prediction only];
24-129 2.76e-09

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 55.32  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  24 YKEQAEAGDAHAQYYLADTYFS----SGDSKQATFWAEKAAKGGDIDAMALLSQI----QFTHGDYAHAKALAQQATIAG 95
Cdd:COG0790  126 YEKAAEQGDADAQYNLGLLYLNgegvPKDPAKAAEWYRKAAEQGDADAQYNLGVLyengRGVPKDPAKALEWYRKAAEQG 205

                         90       100       110
                 ....*....|....*....|....*....|....
gi 503834547  96 SKRGAIMLARVLVNTQAGKTDYPQAIKLLQTATE 129
Cdd:COG0790  206 DADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
81-215 8.00e-07

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 48.39  E-value: 8.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  81 YAHAKALAQQATIAGSKRGAIMLARVLVNTQAGKTDYPQAIKLLQTATEDIDSDSAVDAQLLLGLIYANGVEVAQDDAKA 160
Cdd:COG0790    7 AAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKA 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 503834547 161 ASWFKRSSSLSRtGYAEYWAGMLFQQGEkgFITPNKQKALYWLNLSCSEGFDTGC 215
Cdd:COG0790   87 LEWFEKAAEQGD-AEAQYNLGLMYEEGL--GVPQDYAKALEWYEKAAEQGDADAQ 138
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 27-166 4.74e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 4.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  27 QAEAGDAHAQYYLADTYFSSGDSKQATFWAEKAAKGGDIDAMAL--LSQIQFTHGDYAHAKALAQQATIA--GSKRGAIM 102
Cdd:COG2956  104 ELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYceLAELYLEQGDYDEAIEALEKALKLdpDCARALLL 183

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503834547 103 LARVLVNTQagktDYPQAIKLLQTAtEDIDSDSAvDAQLLLGLIYANgvevAQDDAKAASWFKR 166
Cdd:COG2956  184 LAELYLEQG----DYEEAIAALERA-LEQDPDYL-PALPRLAELYEK----LGDPEEALELLRK 237
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 26-161 2.16e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  26 EQAEAGDAHAQYYLADTYFSSGDSKQATFWAEKAAK--GGDIDAMALLSQIQFTHGDYAHAKALAQQATIAGSKRGAIML 103
Cdd:COG2956  137 LKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKldPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP 216

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503834547 104 ARVLVNTQAGktDYPQAIKLLQTATEDIDSDSAVDAQLLLgLIYANGVEVAQDDAKAA 161
Cdd:COG2956  217 RLAELYEKLG--DPEEALELLRKALELDPSDDLLLALADL-LERKEGLEAALALLERQ 271
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 27-136 2.56e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  27 QAEAGDAHAQYYLADTYFSSGDSKQATFWAEKAAK--GGDIDAMALLSQIQFTHGDYAHAKALAQQATIA--GSKRGAIM 102
Cdd:COG4235   11 AANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRldPDNADALLDLAEALLAAGDTEEAEELLERALALdpDNPEALYL 90

                         90       100       110
                 ....*....|....*....|....*....|....
gi 503834547 103 LARVLVNTQagktDYPQAIKLLQTATEDIDSDSA 136
Cdd:COG4235   91 LGLAAFQQG----DYAEAIAAWQKLLALLPADAP 120
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 33-166 2.88e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  33 AHAQYYLADTYFSSGDSKQATFWAEKAAK--GGDIDAMALLSQIQFTHGDYAHAKALAQQATIAGSKRGAIMLARVLVNT 110
Cdd:COG2956   76 AEALLELAQDYLKAGLLDRAEELLEKLLEldPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL 155

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 503834547 111 QAGktDYPQAIKLLQTATEdIDSDSaVDAQLLLGLIYANgvevAQDDAKAASWFKR 166
Cdd:COG2956  156 EQG--DYDEAIEALEKALK-LDPDC-ARALLLLAELYLE----QGDYEEAIAALER 203
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 30-171 1.56e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  30 AGDAHAQYYLADTYFSSGDSKQATFWAEKAAK--GGDIDAMALLSQIQFTHGDYAHAKALAQQATIAGSKRGAIMLARVL 107
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALEldPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503834547 108 VNTQAGktDYPQAIKLLQTATEdIDSDSAvDAQLLLGLIYANgvevAQDDAKAASWFKRSSSLS 171
Cdd:COG4783   81 ALLKAG--DYDEALALLEKALK-LDPEHP-EAYLRLARAYRA----LGRPDEAIAALEKALELD 136
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 32-181 8.57e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.98  E-value: 8.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  32 DAHAQYYLADTYFSSGDSKQATFWAEKAA--KGGDIDAMALLSQIQFTHGDYAHAKALAQQATIAGSKRGAIMLARVLVN 109
Cdd:COG3914  111 NAEALFNLGNLLLALGRLEEALAALRRALalNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNAL 190

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503834547 110 TQAGktDYPQAIKLLQTATEdIDSDSA-VDAQLLLGLIYANGVEVAQDDAKAASWFKRSSSLSRTGYAEYWAG 181
Cdd:COG3914  191 QDLG--RLEEAIAAYRRALE-LDPDNAdAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPD 260
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 137-170 1.51e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.23  E-value: 1.51e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 503834547   137 VDAQLLLGLIYANGVEVAQDDAKAASWFKRSSSL 170
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAEL 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 27-166 7.70e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 36.63  E-value: 7.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503834547  27 QAEAGDAHAQYYLADTYFSSGDSKQATFWAEKAAK--GGDIDAMALLSQIQFTHGDYAHAKALAQQAtiAGSKRGAIMLA 104
Cdd:COG2956   36 ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLErdPDRAEALLELAQDYLKAGLLDRAEELLEKL--LELDPDDAEAL 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503834547 105 RVLVNTQAGKTDYPQAIKLLQTATEdiDSDSAVDAQLLLGLIYANgvevAQDDAKAASWFKR 166
Cdd:COG2956  114 RLLAEIYEQEGDWEKAIEVLERLLK--LGPENAHAYCELAELYLE----QGDYDEAIEALEK 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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