|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
4-397 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 727.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 4 SVFGPRIIQNLLDTDFYKITMMQAVLHNYPNAEVEWEFRCRNGE-NLAPYLAEIRYQVEQLADVSVTHDQLAYLEKIPFI 82
Cdd:PRK05321 2 TWKADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPFF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 83 KPDFIRFLSLFRFNLRYVQVGLDDaGQLAIRVRGPWLHVILYEIPLLAIISEVRNRYRYREVVIEQVRERLYQNLDWLKA 162
Cdd:PRK05321 82 KPDFLDWLRLFRLNPYEVTVSIDD-GQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIELLKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 163 easAEELAGFQLADFGTRRRFSYRVQEEVVHILKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHQQLGPRLVDSQ 242
Cdd:PRK05321 161 ---LPDLSGFKIADFGTRRRFSFEWQEEVVEALKEGLPGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 243 AAALECWVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYERLGIDPKSKTLIFSDGLD 322
Cdd:PRK05321 238 YAALEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLD 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503738970 323 LAKALGLYRALHERINVSFGIGTRLTCDIPGVEPMNIVIKMTACNGAPVAKISDSPGKTQCRDENFVAYLKHVFN 397
Cdd:PRK05321 318 FDKALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVFG 392
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
12-381 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 601.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 12 QNLLDTDFYKITMMQAVLHNYPNAEVEWEFRCRNGEN-LAPYLAEIRYQVEQLADVSVTHDQLAYLEK-IPFIKPDFIRF 89
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPEDfLEEAAEALREQIDHLANLRFSEEELAYLRRsLPFLKPDYLDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 90 LSLFRFNLRYVQVGLDDA-GQLAIRVRGPWLHVILYEIPLLAIISEVRNRYRYREVVIEQVRERLYQNLDWLKAEASAEE 168
Cdd:cd01401 81 LELFRLNPEEVVVRLDTGkGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 169 LAGFQLADFGTRRRFSYRVQEEVVHILKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHQQLGPRLVDSQAAALEC 248
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKQAAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 249 WVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYERLGIDPKSKTLIFSDGLDLAKALG 328
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 503738970 329 LYRALHERINVSFGIGTRLTCDIP---GVEPMNIVIKMTACNGAPVAKISDSPGKT 381
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGnkeKSTPLNIVIKLVECNGRPVAKISDSPGKN 376
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
10-397 |
0e+00 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 509.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 10 IIQNLLDTDFYKITMMQAVLHNYPNAEVEWEFRCRNGENLAPYLAE-IRYQVEQLADVSVTHDQLAYLEK-IPFIKPDFI 87
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQLFLKEAAEaLREEISALGNLRFTDDEIEYLKQeLPYLKSDYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 88 RFLSLFRFN-LRYVQVGLDDAGQLAIRVRGPWLHVILYEIPLLAIISEVRNRYRYREVVIEQVRERLYQNLDWLKAEASA 166
Cdd:TIGR01514 81 DYLRNFRFHpEEQVEVGIDDKGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 167 EEL--AGFQLADFGTRRRFSYRVQEEVVHILKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHQQLGPrLVDSQAA 244
Cdd:TIGR01514 161 ETMfeNGFRFSEFGTRRRFSLEVQDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 245 ALECWVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYERLGIDPKSKTLIFSDGLDLA 324
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503738970 325 KALGLYRALHERINVSFGIGTRLTCDIPGVEPMNIVIKMTACNGAPVAKISDSPGKTQCRDENFVAYLKHVFN 397
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELFD 392
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
172-397 |
6.18e-117 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 339.74 E-value: 6.18e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 172 FQLADFGTRRRFSYRVQEEVVHilkrDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHQQLGPRLVDSQAAALECWVR 251
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQEIVGL----AHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 252 EYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYERL-GIDPKSKTLIFSDGLDLAKALGLY 330
Cdd:pfam04095 77 EYRGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTlNIDGYTKRLIFSDGLDVEKIIELL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503738970 331 RALHE-RINVSFGIGTRLTCDIPG--------VEPMNIVIKMTACNGAPVAKISDSPGKTQCRDENFVAYLKHVFN 397
Cdd:pfam04095 157 EYFKGkGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFD 232
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
14-381 |
5.59e-41 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 150.30 E-value: 5.59e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 14 LLDTDFYKITMMQAVLHN-YPNAEVEWEFRCRNGENLAPYL--AEIRYQVEQLADVSVTHDQLAYLEKIPFIKPDFIRFL 90
Cdd:COG1488 5 ALLTDLYKLTMAQAYLPEgTANRRAVFELFFRRLPFGRGYVvfAGLQRFLKYLENLRFTEEDIAYLRSLGVFDEDFLDYL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 91 SLFRFNLRYvqvgldDA---GQLA------IRVRGPWLHVILYEIPLLAIIsevrnryryrevvieqvrerlyqNLDWLK 161
Cdd:COG1488 85 ADFRFPGDI------RAvpeGTVVfpgeplLTVEGTLPEAQLLETLLLNIL-----------------------NYPTLI 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 162 AEASAE-ELA--GFQLADFGTRRrfsyrVQEEVVHILKrdfpGR------FVGTSNVHLAREYQLKPIGTMAHEWFMAHq 232
Cdd:COG1488 136 ATKAARiVQAagGRPLHDFGLRR-----AHGLEAAVAA----ARaaylagFAGTSNVLAGRYYGIPSVGTMAHSFVQAH- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 233 qlgprlvDSQAAALECWVREYRGLLgIALTDciTMDAF--------LGDfDLYFAKLFDGLRHDSGDPLAWAEKAIAHYE 304
Cdd:COG1488 206 -------DDELEAFRAFAEAYPDGT-TLLVD--TYDTLsgvpnaieLAK-ELLARGGLLGIRLDSGDLAYLSKQARELLD 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 305 RLGidPKSKTLIFSDGLDLAKALGLYRAlHERINVsFGIGTRL----TCDIPGvepmnIVIKMTACNGA----PVAKISD 376
Cdd:COG1488 275 EAG--LPDVRIIASDDLDEYRIAALLEQ-GAPIDV-FGVGTRLvtssDRPTLG-----FVYKLVAVEGDgewrPVIKLSE 345
|
....*
gi 503738970 377 SPGKT 381
Cdd:COG1488 346 TPGKK 350
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
4-397 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 727.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 4 SVFGPRIIQNLLDTDFYKITMMQAVLHNYPNAEVEWEFRCRNGE-NLAPYLAEIRYQVEQLADVSVTHDQLAYLEKIPFI 82
Cdd:PRK05321 2 TWKADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPFF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 83 KPDFIRFLSLFRFNLRYVQVGLDDaGQLAIRVRGPWLHVILYEIPLLAIISEVRNRYRYREVVIEQVRERLYQNLDWLKA 162
Cdd:PRK05321 82 KPDFLDWLRLFRLNPYEVTVSIDD-GQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIELLKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 163 easAEELAGFQLADFGTRRRFSYRVQEEVVHILKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHQQLGPRLVDSQ 242
Cdd:PRK05321 161 ---LPDLSGFKIADFGTRRRFSFEWQEEVVEALKEGLPGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 243 AAALECWVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYERLGIDPKSKTLIFSDGLD 322
Cdd:PRK05321 238 YAALEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLD 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503738970 323 LAKALGLYRALHERINVSFGIGTRLTCDIPGVEPMNIVIKMTACNGAPVAKISDSPGKTQCRDENFVAYLKHVFN 397
Cdd:PRK05321 318 FDKALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVFG 392
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
12-381 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 601.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 12 QNLLDTDFYKITMMQAVLHNYPNAEVEWEFRCRNGEN-LAPYLAEIRYQVEQLADVSVTHDQLAYLEK-IPFIKPDFIRF 89
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPEDfLEEAAEALREQIDHLANLRFSEEELAYLRRsLPFLKPDYLDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 90 LSLFRFNLRYVQVGLDDA-GQLAIRVRGPWLHVILYEIPLLAIISEVRNRYRYREVVIEQVRERLYQNLDWLKAEASAEE 168
Cdd:cd01401 81 LELFRLNPEEVVVRLDTGkGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 169 LAGFQLADFGTRRRFSYRVQEEVVHILKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHQQLGPRLVDSQAAALEC 248
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKQAAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 249 WVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYERLGIDPKSKTLIFSDGLDLAKALG 328
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 503738970 329 LYRALHERINVSFGIGTRLTCDIP---GVEPMNIVIKMTACNGAPVAKISDSPGKT 381
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGnkeKSTPLNIVIKLVECNGRPVAKISDSPGKN 376
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
10-397 |
0e+00 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 509.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 10 IIQNLLDTDFYKITMMQAVLHNYPNAEVEWEFRCRNGENLAPYLAE-IRYQVEQLADVSVTHDQLAYLEK-IPFIKPDFI 87
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQLFLKEAAEaLREEISALGNLRFTDDEIEYLKQeLPYLKSDYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 88 RFLSLFRFN-LRYVQVGLDDAGQLAIRVRGPWLHVILYEIPLLAIISEVRNRYRYREVVIEQVRERLYQNLDWLKAEASA 166
Cdd:TIGR01514 81 DYLRNFRFHpEEQVEVGIDDKGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 167 EEL--AGFQLADFGTRRRFSYRVQEEVVHILKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHQQLGPrLVDSQAA 244
Cdd:TIGR01514 161 ETMfeNGFRFSEFGTRRRFSLEVQDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 245 ALECWVREYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYERLGIDPKSKTLIFSDGLDLA 324
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503738970 325 KALGLYRALHERINVSFGIGTRLTCDIPGVEPMNIVIKMTACNGAPVAKISDSPGKTQCRDENFVAYLKHVFN 397
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELFD 392
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
172-397 |
6.18e-117 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 339.74 E-value: 6.18e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 172 FQLADFGTRRRFSYRVQEEVVHilkrDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHQQLGPRLVDSQAAALECWVR 251
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQEIVGL----AHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 252 EYRGLLGIALTDCITMDAFLGDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYERL-GIDPKSKTLIFSDGLDLAKALGLY 330
Cdd:pfam04095 77 EYRGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTlNIDGYTKRLIFSDGLDVEKIIELL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503738970 331 RALHE-RINVSFGIGTRLTCDIPG--------VEPMNIVIKMTACNGAPVAKISDSPGKTQCRDENFVAYLKHVFN 397
Cdd:pfam04095 157 EYFKGkGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFD 232
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
14-362 |
2.64e-107 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 319.22 E-value: 2.64e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 14 LLDTDFYKITMMQAVLHNYPNAEVEWEFRCRNGENLAPY--LAEIRYQVEQLADVSVTHDQLAYLEKI----------PF 81
Cdd:cd01567 1 LLDTDLYKLTMMQAYLYPYPNTRVVFEFTFRSNPFGGDYivFAGLEEVLKLLENLRFTEEEIEYLKKLlifgefflylLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 82 IKPDFIRFLSLFRFNLRYVqvglddaGQLAIRVRGPWLHVILYEIPLLAIISEVRNRYRYREVVIEQVRERLYqnldwlk 161
Cdd:cd01567 81 LGKLPLEIYALPEGTVVFP-------KEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLLE------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 162 aEASAEELAGFQLADFGTRRRFSYrvqEEVVHILKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHQQLgprlVDS 241
Cdd:cd01567 147 -TKDNLEELGFKLHDFGTRRRHSP---EAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGAL----EEA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 242 QAAALECWVREYRGLLGIALTDCITMD-AFLGDFDLYFAKL----FDGLRHDSGDPLAWAEKAIAHYERLGIDPKSKTLI 316
Cdd:cd01567 219 AFEAFARWLPQFGGGLGIALIDTYDTDnGFLNALKLAKALGagggLLGVRLDSGDPVELIKKVRKHLDELGIDLNKKKII 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 503738970 317 FSDGLDLAKALGLYRALHERINVSFGIGTRLTCDIpGVEPMNIVIK 362
Cdd:cd01567 299 ISGDLDTEEAIELLLEQGASPNDAFGVGTSLTNDL-GRPPLGFVYK 343
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
18-362 |
2.06e-54 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 181.28 E-value: 2.06e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 18 DFYKITMMQAvlHNYPNAEVEWEFRCRNGENLapYLAEIRYQVEqladvsvthdqlaYLEKIPFikPDFIRFLSLFRFNL 97
Cdd:cd00516 1 DLYKLTMIQA--YPPPDTRATAEFTAREDPYG--VLAGLEEALE-------------LLELLRF--PGPLVILAVPEGTV 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 98 RYvqvglddAGQLAIRVRGPWLHVILYEIPLLAIISEVRNRYRYREVVIEQVRErlyqnldwlkaeasaeelAGFQLADF 177
Cdd:cd00516 62 VE-------PGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAKG------------------ANTKVHDF 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 178 GTRRRFSY-RVQEevvhiLKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHqqlgprLVDSQAAALECWVREyrgl 256
Cdd:cd00516 117 GTRKTTPGlRLLE-----KYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF------GELAAVKALRRWLPE---- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 257 LGIALTDCITMDaFLGDFDLYFAKLFDGLRHDSG-----DPLAWAEKAIAHYErlGIDPKSKTLIFSDGLDLAKAlglyR 331
Cdd:cd00516 182 LFIALIDVEVDT-LEEALEAAKAGGADGIRLDSGspeelDPAVLILKARAHLD--GKGLPRVKIEASGGLDEENI----R 254
|
330 340 350
....*....|....*....|....*....|.
gi 503738970 332 ALHERINVSFGIGTRLTCDipgvEPMNIVIK 362
Cdd:cd00516 255 AYAETGVDVFGVGTLLHSA----PPLDIVLK 281
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
15-133 |
2.70e-43 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 147.27 E-value: 2.70e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 15 LDTDFYKITMMQAVLHNYPNAEVEWEFRCRN--GENLAPYLAEIRYQVEQLADVSVTHDQLAYL-EKIPFIKPDFIRFLS 91
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQVVFEFFNRTnpFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLrRSLPYFKPDFLDYLR 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 503738970 92 LFRFNLRYVQV---GLDDAGQLAIRVRGPWLHVILYEIPLLAIIS 133
Cdd:pfam17767 81 NFRFDPSIVAVpegEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
14-381 |
5.59e-41 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 150.30 E-value: 5.59e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 14 LLDTDFYKITMMQAVLHN-YPNAEVEWEFRCRNGENLAPYL--AEIRYQVEQLADVSVTHDQLAYLEKIPFIKPDFIRFL 90
Cdd:COG1488 5 ALLTDLYKLTMAQAYLPEgTANRRAVFELFFRRLPFGRGYVvfAGLQRFLKYLENLRFTEEDIAYLRSLGVFDEDFLDYL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 91 SLFRFNLRYvqvgldDA---GQLA------IRVRGPWLHVILYEIPLLAIIsevrnryryrevvieqvrerlyqNLDWLK 161
Cdd:COG1488 85 ADFRFPGDI------RAvpeGTVVfpgeplLTVEGTLPEAQLLETLLLNIL-----------------------NYPTLI 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 162 AEASAE-ELA--GFQLADFGTRRrfsyrVQEEVVHILKrdfpGR------FVGTSNVHLAREYQLKPIGTMAHEWFMAHq 232
Cdd:COG1488 136 ATKAARiVQAagGRPLHDFGLRR-----AHGLEAAVAA----ARaaylagFAGTSNVLAGRYYGIPSVGTMAHSFVQAH- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 233 qlgprlvDSQAAALECWVREYRGLLgIALTDciTMDAF--------LGDfDLYFAKLFDGLRHDSGDPLAWAEKAIAHYE 304
Cdd:COG1488 206 -------DDELEAFRAFAEAYPDGT-TLLVD--TYDTLsgvpnaieLAK-ELLARGGLLGIRLDSGDLAYLSKQARELLD 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 305 RLGidPKSKTLIFSDGLDLAKALGLYRAlHERINVsFGIGTRL----TCDIPGvepmnIVIKMTACNGA----PVAKISD 376
Cdd:COG1488 275 EAG--LPDVRIIASDDLDEYRIAALLEQ-GAPIDV-FGVGTRLvtssDRPTLG-----FVYKLVAVEGDgewrPVIKLSE 345
|
....*
gi 503738970 377 SPGKT 381
Cdd:COG1488 346 TPGKK 350
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
15-381 |
1.15e-30 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 122.08 E-value: 1.15e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 15 LDTDFYKITMMQAVLHNYPN---AEVEWEFRCRNGENLAPYLAEIRYQVEQLADVSVTHDQLAYLEKIPFIKPDFIRFLS 91
Cdd:TIGR01513 2 LLTDLYELTMAQGYFREGKAnqpAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLGIFDDAFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 92 LFRFNL--RYVQVG-LDDAGQLAIRVRGPWLHVILYEIPLLAIISevrnryryrevvieqvrerlYQNLDWLKAEASAEE 168
Cdd:TIGR01513 82 EFRFSGtvRALPEGsLVFPNEPLLQVEGPLIEAQLLETLVLNIIN--------------------FQTLIATKAARIVLA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 169 LAGFQLADFGTRRRFSYrvqEEVVHILKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHqqlgprlvDSQAAALEC 248
Cdd:TIGR01513 142 AGGKPLLEFGLRRAQGP---DAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF--------DNELAAFRA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 249 WVREY----RGL------LGIALTDCITMDAFLGDfdlyfAKLFDGLRHDSGDPLAWAEKAIAHYERLGIdPKSKtLIFS 318
Cdd:TIGR01513 211 YAKLYpkatVLLvdtydtLRSGLPNAIAVAKELGE-----QGKVVGVRIDSGDLLYLSKQARKQLDAAGL-TQVK-IVVS 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503738970 319 DGLDLAKALGLyRALHERINVsFGIGTRL-TCdiPGVEPMNIVIKMTACNGAPVAKISDSPGKT 381
Cdd:TIGR01513 284 NDLDENSIAAL-KAEGAPIDV-YGVGTSLvTA--SDAPALGGVYKLVAYEGRPVMKLSENPEKS 343
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
15-349 |
5.37e-19 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 86.86 E-value: 5.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 15 LDTDFYKITMMQAVLH-NYPNAEVEWEFRCRNGENLAPYL--AEIRYQVEQLADVSVTHDQLAYLEKIPFIKPDFIRFLS 91
Cdd:cd01570 2 LLTDLYQLTMAQAYWKeGKHNKPAVFELFFRKLPFGGGYAvfAGLEELLEYLENFRFTEEDIDYLRSLGIFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 92 LFRF--NLRYVQVG-LDDAGQLAIRVRGPWLHVILYEIPLLAIISevrnryryrevvieqvrerlYQNLDWLKAEASAEE 168
Cdd:cd01570 82 GFRFtgTIYAIPEGeVVFPNEPLLTVEGPLIEAQLLETLLLNLIN--------------------FQTLIATKAARVRLA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 169 LAGFQLADFGTRR-----------RFSYRvqeevvhilkrdfpGRFVGTSNVHLAREYQLKPIGTMAHEWFMAHqqlgpr 237
Cdd:cd01570 142 AGGRPLLEFGLRRaqgpdaalsaaRAAYI--------------GGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF------ 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 238 lvDSQAAALECWVREYRGLLgIALTDciTMD-----------AFLGDFDLYFaKLFdGLRHDSGDPLAWAEKAIAHYERL 306
Cdd:cd01570 202 --DDELAAFRAFAEAYPDNF-TLLVD--TYDtlrsglpnaiaVAKELGALGY-RLV-GVRIDSGDLAYLSKEARKMLDEA 274
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 503738970 307 GIdpkSKTLIF-SDGLDLAKALGLYRALHErINVsFGIGTRL-TC 349
Cdd:cd01570 275 GL---TKVKIVaSNDLDEYTIAALNAQGAP-IDA-FGVGTRLvTS 314
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
15-382 |
3.81e-18 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 85.57 E-value: 3.81e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 15 LDTDFYKITMMQAVLHNYPNAEVEWEFRCRNGENLAPYL--AEIRYQVEQLADVSVTHDQLAYLEKIPFIKPDFIRFLSL 92
Cdd:PRK12484 6 LLTDLYEVTMANAYLREGMSAPATFSLFYRKLPDGRGFLiaAGLADVVEFLEAFRFDEQDLRYLRGLNQFSEEFLAWLAG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 93 FRF--NLRYVQVG-LDDAGQLAIRVRGPWLHVILYEIPLLAIISevrnryryrevvieqvrerlYQNLDWLKAEASAEEL 169
Cdd:PRK12484 86 LRFtgDVRAVPEGtVVFPNEPLLEVTAPLIEAQLVETFLLNQIN--------------------HQSLIASKAARCVLAA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 170 AGFQLADFGTRRRFSYrvqEEVVHILKRDFPGRFVGTSNVHLAREYQLKPIGTMAHEWFMAhqqlgprlVDSQAAALECW 249
Cdd:PRK12484 146 AGRPVVDFGARRAHGT---DAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEA--------FPDEVAAFRAF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 250 VREYRGLLgIALTDciTMDAFLG---------DFDLYFAKLfdGLRHDSGDPLAWAEKAIAHYERLGIdPKSKTLIfSDG 320
Cdd:PRK12484 215 ARLYPDAT-TLLVD--TYDTLRGvrnaievakELGNRFDPR--GVRLDSGDLAELSKATRAILDAAGL-EQVKIVA-SGG 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503738970 321 LDLAKALGLYRAlHERINVsFGIGTRL--TCDIPGvepMNIVIKMTACNGAPVAKISD----SPGKTQ 382
Cdd:PRK12484 288 LDEYRIAALLAA-GAPIDG-FGVGTRLgvAADAPV---LDSAYKLVAYEGRGVTKLSSgkvtYPGRKQ 350
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
15-381 |
6.33e-17 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 82.13 E-value: 6.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 15 LDTDFYKITMMQAVLHNYPNAEV---EWEFRcRNGENlAPY-----LAEIryqVEQLADVSVTHDQLAYLEKIPFIKPDF 86
Cdd:PRK09243 11 LLTDLYELTMAQAYLRDGIHNRRavfELFFR-KLPFG-RGYavfagLERL---LEYLENLRFTEEDIEYLRSLGIFDEDF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 87 IRFLSLFRF--NLRYVQVG-LDDAGQLAIRVRGPWLHVILYEIPLLAIIsevrnryryrevvieqvrerlyqNLDWLKAE 163
Cdd:PRK09243 86 LDYLRNFRFtgDVRAVPEGeLVFPNEPLLRVEGPLAEAQLLETLLLNII-----------------------NFQTLIAT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 164 ASA---EELAGFQLADFGTRR-----------RFSYrvqeevvhIlkrdfpGRFVGTSNVHLAREYQLKPIGTMAHEWFM 229
Cdd:PRK09243 143 KAArivSAAGGRPLLEFGSRRaqgpdaavwaaRAAY--------I------GGFDATSNVLAGKRYGIPVSGTMAHSFVQ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 230 AHqqlgprlvDSQAAALECWVREYRgllgialTDCItmdaFLGD-FD---------------LYFAKLFDGLRHDSGDpL 293
Cdd:PRK09243 209 AF--------DDEYEAFRAYAETYP-------DNTV----LLVDtYDtlksgvpnaikvakeLGDGIELGGVRIDSGD-L 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503738970 294 AW-AEKAIAHYERLGIdpkSKTLIF-SDGLDLAKALGLYRAlHERINVsFGIGTRL-TCDipGVEPMNIVIKMTACNGA- 369
Cdd:PRK09243 269 AYlSKKVRKMLDEAGF---TDTKIVaSNDLDEYTIASLKLQ-GAPIDG-FGVGTKLvTGS--DAPALGGVYKLVAIEGEg 341
|
410
....*....|....*
gi 503738970 370 ---PVAKISDSPGKT 381
Cdd:PRK09243 342 gmiPKIKLSNSPEKV 356
|
|
| |
