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Conserved domains on  [gi|503622151|ref|WP_013856227|]
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MULTISPECIES: methyltransferase domain-containing protein [Vibrio]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_11 super family cl48003
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 71-125 2.50e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


The actual alignment was detected with superfamily member pfam08241:

Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 55.75  E-value: 2.50e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 503622151   71 ENPLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIII 125
Cdd:pfam08241  40 REGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 71-125 2.50e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 55.75  E-value: 2.50e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 503622151   71 ENPLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIII 125
Cdd:pfam08241  40 REGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 73-140 4.83e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 56.16  E-value: 4.83e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503622151  73 PLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIIITGFNPISFTGIASLM 140
Cdd:COG2226   70 NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
PRK08317 PRK08317
hypothetical protein; Provisional
 73-125 7.72e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.92  E-value: 7.72e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503622151  73 PLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIII 125
Cdd:PRK08317  70 NVEFVRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVV 122
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 70-158 6.20e-03

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 36.86  E-value: 6.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503622151   70 IENPLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIIITGFNPISFTGIASLMPW-RKHNLP 148
Cdd:TIGR01934  86 LPLNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANALLKKFYKFyLKNVLP 165

                          90
                  ....*....|
gi 503622151  149 WSGRMFTANR 158
Cdd:TIGR01934 166 SIGGLISKNA 175
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 71-125 2.50e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 55.75  E-value: 2.50e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 503622151   71 ENPLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIII 125
Cdd:pfam08241  40 REGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 73-140 4.83e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 56.16  E-value: 4.83e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503622151  73 PLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIIITGFNPISFTGIASLM 140
Cdd:COG2226   70 NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 71-129 2.90e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 45.39  E-value: 2.90e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 503622151  71 ENPLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIIITGFN 129
Cdd:COG2227   68 ELNVDFVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
83-156 3.56e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 40.37  E-value: 3.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503622151  83 ELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIIIT-------GFNPISFTGIASLMpwRKHNLPWSGRMFT 155
Cdd:COG4976  100 DLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSvedadgsGRYAHSLDYVRDLL--AAAGFEVPGLLVV 177


                 .
gi 503622151 156 A 156
Cdd:COG4976  178 A 178
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 74-121 3.87e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 38.70  E-value: 3.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 503622151   74 LHTVIADSYELPFLEKSFDVAILAHQLDYCGDP--HRILREVDRVMMDDG 121
Cdd:pfam13649  47 VEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDPdlEAALREIARVLKPGG 96
PRK08317 PRK08317
hypothetical protein; Provisional
 73-125 7.72e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.92  E-value: 7.72e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503622151  73 PLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIII 125
Cdd:PRK08317  70 NVEFVRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVV 122
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 70-158 6.20e-03

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 36.86  E-value: 6.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503622151   70 IENPLHTVIADSYELPFLEKSFDVAILAHQLDYCGDPHRILREVDRVMMDDGYIIITGFNPISFTGIASLMPW-RKHNLP 148
Cdd:TIGR01934  86 LPLNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANALLKKFYKFyLKNVLP 165

                          90
                  ....*....|
gi 503622151  149 WSGRMFTANR 158
Cdd:TIGR01934 166 SIGGLISKNA 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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