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Conserved domains on  [gi|503545240|ref|WP_013779316|]
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isocitrate/isopropylmalate family dehydrogenase [Tepidanaerobacter acetatoxydans]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 1904402)

isocitrate/isopropylmalate dehydrogenase family protein similar to homoisocitrate dehydrogenase, which catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LeuB super family cl43150
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 42-382 9.31e-100

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


The actual alignment was detected with superfamily member COG0473:

Pssm-ID: 440241  Cd Length: 346  Bit Score: 299.62  E-value: 9.31e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  42 IGILPGDGVGPIIMKQALRVLNHLLQKEIAEkkIEIRIID--GLTIEnrsAKMQTVPDDVLEAIKKCNVILKGPTVTPKA 119
Cdd:COG0473    4 IAVLPGDGIGPEVVAAALKVLEAAAERFGLD--FEFEEADigGAAYD---KTGTPLPDETLEALRKADAILLGAVGGPKW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 120 TD---PWpnlpSANATLRRELDLFANLRPVKIPE-----------KNIDWAFFRENIEGAYIlGSKGIQV---NEDLAID 182
Cdd:COG0473   79 DDgvrPE----SGLLALRKELDLYANLRPAKLYPglpsplkpeivEGIDLVIVRENTEGLYF-GIGGRIGtgtGEEVAID 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 183 FVVETKQGSDRIARAAFEYAKNNGKKnITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNPE-FN 260
Cdd:COG0473  154 TRVYTRKGIERIARYAFELARKRRKK-VTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLvRNPEqFD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 261 kgleVFVLPNLYGDIITDIAAEIQGGLGTAGSANIG-KRYAVFEAIHGTAPDLInnGRGdYANPCSLLRAVAMLLSHIGY 339
Cdd:COG0473  233 ----VIVTENLFGDILSDLAAGLTGSLGLAPSANIGdEGKALFEPVHGSAPDIA--GKG-IANPIATILSAAMMLRHLGE 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 503545240 340 NDKSFQLDKALEictiterKVVVTTKKT-----DASAAEFTDYLLETL 382
Cdd:COG0473  306 EEAADAIEAAVE-------KVLAEGVRTpdlggKAGTSEMGDAIIAAL 346
 
Name Accession Description Interval E-value
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 42-382 9.31e-100

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 299.62  E-value: 9.31e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  42 IGILPGDGVGPIIMKQALRVLNHLLQKEIAEkkIEIRIID--GLTIEnrsAKMQTVPDDVLEAIKKCNVILKGPTVTPKA 119
Cdd:COG0473    4 IAVLPGDGIGPEVVAAALKVLEAAAERFGLD--FEFEEADigGAAYD---KTGTPLPDETLEALRKADAILLGAVGGPKW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 120 TD---PWpnlpSANATLRRELDLFANLRPVKIPE-----------KNIDWAFFRENIEGAYIlGSKGIQV---NEDLAID 182
Cdd:COG0473   79 DDgvrPE----SGLLALRKELDLYANLRPAKLYPglpsplkpeivEGIDLVIVRENTEGLYF-GIGGRIGtgtGEEVAID 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 183 FVVETKQGSDRIARAAFEYAKNNGKKnITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNPE-FN 260
Cdd:COG0473  154 TRVYTRKGIERIARYAFELARKRRKK-VTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLvRNPEqFD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 261 kgleVFVLPNLYGDIITDIAAEIQGGLGTAGSANIG-KRYAVFEAIHGTAPDLInnGRGdYANPCSLLRAVAMLLSHIGY 339
Cdd:COG0473  233 ----VIVTENLFGDILSDLAAGLTGSLGLAPSANIGdEGKALFEPVHGSAPDIA--GKG-IANPIATILSAAMMLRHLGE 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 503545240 340 NDKSFQLDKALEictiterKVVVTTKKT-----DASAAEFTDYLLETL 382
Cdd:COG0473  306 EEAADAIEAAVE-------KVLAEGVRTpdlggKAGTSEMGDAIIAAL 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
36-342 2.65e-79

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 251.73  E-value: 2.65e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  36 KLDKVIIGILPGDGVGPIIMKQALRVLnhllqkEIAEKKIEIRIID-GltiENRSAKMQT--VPDDVLEAIKKCNVILKG 112
Cdd:PRK09222   1 MAEKTPITVAYGDGIGPEIMEAVLKIL------EAAGAPLEIETIEiG---EKVYKKGWTsgISPSAWESIRRTKVLLKA 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 113 PTVTP-----KatdpwpnlpSANATLRRELDLFANLRP-------VKIPEKNIDWAFFRENIEGAYilgsKGI--QVNED 178
Cdd:PRK09222  72 PITTPqgggyK---------SLNVTLRKTLGLYANVRPcvsyhpfVETKHPNLDVVIIRENEEDLY----AGIehRQTPD 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 179 LAIDFVVETKQGSDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNP 257
Cdd:PRK09222 139 VYQCLKLISRPGSEKIIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLaTNP 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 258 E-FnkglEVFVLPNLYGDIITDIAAEIQGGLGTAGSANIGKRYAVFEAIHGTAPDLInnGRgDYANPCSLLRAVAMLLSH 336
Cdd:PRK09222 219 EnF----DVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEYAMFEAVHGSAPDIA--GK-NIANPSGLLNAAVMMLVH 291


                 ....*.
gi 503545240 337 IGYNDK 342
Cdd:PRK09222 292 IGQFDI 297
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
41-376 8.88e-71

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 225.64  E-value: 8.88e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240   41 IIGILPGDGVGPIIMKQALRVLNHLLQKEIAEKKIEIRIIDGLTIEnrsAKMQTVPDDVLEAIKKCNVILKGPTVTPKAT 120
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAID---ETGEPLPDETLEACKKADAVLLGAVGGPKWD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  121 DPwpNLPSANA--TLRRELDLFANLRPVKI--------PEK----NIDWAFFRENIEGAYILGSKGIQVNEDL-AIDFVV 185
Cdd:pfam00180  78 PA--GVRPENGllALRKELGLFANLRPAKVfpplgdasPLKneveGVDIVIVRELTGGIYFGIEKGIKGSGNEvAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  186 ETKQGSDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGnFIKAVRKVGQ-EYPDIDIQERYVDATAAKL-NNPEFNkgl 263
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKaEYPDVELEHQLVDNAAMQLvKNPSQF--- 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  264 EVFVLPNLYGDIITDIAAEIQGGLGTAGSANIG-KRYAVFEAIHGTAPDLinnGRGDYANPCSLLRAVAMLLSH-IGYND 341
Cdd:pfam00180 232 DVIVTPNLFGDILSDEASMLTGSLGLLPSASLGaNGFGIFEPVHGSAPDI---AGKGIANPIATILSAAMMLRYsLGLED 308

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 503545240  342 KSFQLDKALeICTITERKVV--VTTKKTDASAAEFTD 376
Cdd:pfam00180 309 AADKIEAAV-LKVLESGIRTgdLAGSATYVSTSEFGE 344
 
Name Accession Description Interval E-value
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 42-382 9.31e-100

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 299.62  E-value: 9.31e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  42 IGILPGDGVGPIIMKQALRVLNHLLQKEIAEkkIEIRIID--GLTIEnrsAKMQTVPDDVLEAIKKCNVILKGPTVTPKA 119
Cdd:COG0473    4 IAVLPGDGIGPEVVAAALKVLEAAAERFGLD--FEFEEADigGAAYD---KTGTPLPDETLEALRKADAILLGAVGGPKW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 120 TD---PWpnlpSANATLRRELDLFANLRPVKIPE-----------KNIDWAFFRENIEGAYIlGSKGIQV---NEDLAID 182
Cdd:COG0473   79 DDgvrPE----SGLLALRKELDLYANLRPAKLYPglpsplkpeivEGIDLVIVRENTEGLYF-GIGGRIGtgtGEEVAID 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 183 FVVETKQGSDRIARAAFEYAKNNGKKnITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNPE-FN 260
Cdd:COG0473  154 TRVYTRKGIERIARYAFELARKRRKK-VTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLvRNPEqFD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 261 kgleVFVLPNLYGDIITDIAAEIQGGLGTAGSANIG-KRYAVFEAIHGTAPDLInnGRGdYANPCSLLRAVAMLLSHIGY 339
Cdd:COG0473  233 ----VIVTENLFGDILSDLAAGLTGSLGLAPSANIGdEGKALFEPVHGSAPDIA--GKG-IANPIATILSAAMMLRHLGE 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 503545240 340 NDKSFQLDKALEictiterKVVVTTKKT-----DASAAEFTDYLLETL 382
Cdd:COG0473  306 EEAADAIEAAVE-------KVLAEGVRTpdlggKAGTSEMGDAIIAAL 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
36-342 2.65e-79

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 251.73  E-value: 2.65e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  36 KLDKVIIGILPGDGVGPIIMKQALRVLnhllqkEIAEKKIEIRIID-GltiENRSAKMQT--VPDDVLEAIKKCNVILKG 112
Cdd:PRK09222   1 MAEKTPITVAYGDGIGPEIMEAVLKIL------EAAGAPLEIETIEiG---EKVYKKGWTsgISPSAWESIRRTKVLLKA 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 113 PTVTP-----KatdpwpnlpSANATLRRELDLFANLRP-------VKIPEKNIDWAFFRENIEGAYilgsKGI--QVNED 178
Cdd:PRK09222  72 PITTPqgggyK---------SLNVTLRKTLGLYANVRPcvsyhpfVETKHPNLDVVIIRENEEDLY----AGIehRQTPD 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 179 LAIDFVVETKQGSDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNP 257
Cdd:PRK09222 139 VYQCLKLISRPGSEKIIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLaTNP 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 258 E-FnkglEVFVLPNLYGDIITDIAAEIQGGLGTAGSANIGKRYAVFEAIHGTAPDLInnGRgDYANPCSLLRAVAMLLSH 336
Cdd:PRK09222 219 EnF----DVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEYAMFEAVHGSAPDIA--GK-NIANPSGLLNAAVMMLVH 291


                 ....*.
gi 503545240 337 IGYNDK 342
Cdd:PRK09222 292 IGQFDI 297
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 42-382 2.99e-77

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 241.93  E-value: 2.99e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  42 IGILPGDGVGPIIMKQALRVLNHL---LQKEIAEKkieiriidGLTIENRSAKMqtVPDDVLEAIKKCNVILKGPTVTPK 118
Cdd:PRK08997   5 ITVIPGDGIGPSIIDATLKILDKLgcdFEYEFADA--------GLTALEKHGEL--LPQRTLDLIEKNKIALKGPLTTPV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 119 ATdpwpNLPSANATLRRELDLFANLRPVK-IPE-----KNIDWAFFRENIEGAYIlgSKGIQVNED--LAIDFVVETKQG 190
Cdd:PRK08997  75 GE----GFTSINVTLRKKFDLYANVRPVLsFPGtkaryDNIDIITVRENTEGMYS--GEGQTVSEDgeTAEATSIITRKG 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 191 SDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNPEfnkGLEVFVLP 269
Cdd:PRK08997 149 AERIVRFAYELARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLvMNPE---QFDVIVTT 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 270 NLYGDIITDIAAEIQGGLGTAGSANIGKRYAVFEAIHGTAPDLINNGRgdyANPCSLLRAVAMLLSHIGYNDKSFQLDKA 349
Cdd:PRK08997 226 NLFGDILSDLCAGLVGGLGMAPGANIGRDAAIFEAVHGSAPDIAGKNL---ANPTSVILAAIQMLEYLGMPDKAERIRKA 302

                        330       340       350
                 ....*....|....*....|....*....|...
gi 503545240 350 LEiCTITERKVVVTTKKTDASAAEFTDYLLETL 382
Cdd:PRK08997 303 IV-AVIEAGDRTTRDLGGTHGTTDFTQAVIDRL 334
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
41-376 8.88e-71

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 225.64  E-value: 8.88e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240   41 IIGILPGDGVGPIIMKQALRVLNHLLQKEIAEKKIEIRIIDGLTIEnrsAKMQTVPDDVLEAIKKCNVILKGPTVTPKAT 120
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAID---ETGEPLPDETLEACKKADAVLLGAVGGPKWD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  121 DPwpNLPSANA--TLRRELDLFANLRPVKI--------PEK----NIDWAFFRENIEGAYILGSKGIQVNEDL-AIDFVV 185
Cdd:pfam00180  78 PA--GVRPENGllALRKELGLFANLRPAKVfpplgdasPLKneveGVDIVIVRELTGGIYFGIEKGIKGSGNEvAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  186 ETKQGSDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGnFIKAVRKVGQ-EYPDIDIQERYVDATAAKL-NNPEFNkgl 263
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKaEYPDVELEHQLVDNAAMQLvKNPSQF--- 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  264 EVFVLPNLYGDIITDIAAEIQGGLGTAGSANIG-KRYAVFEAIHGTAPDLinnGRGDYANPCSLLRAVAMLLSH-IGYND 341
Cdd:pfam00180 232 DVIVTPNLFGDILSDEASMLTGSLGLLPSASLGaNGFGIFEPVHGSAPDI---AGKGIANPIATILSAAMMLRYsLGLED 308

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 503545240  342 KSFQLDKALeICTITERKVV--VTTKKTDASAAEFTD 376
Cdd:pfam00180 309 AADKIEAAV-LKVLESGIRTgdLAGSATYVSTSEFGE 344
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 42-351 9.42e-61

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 199.20  E-value: 9.42e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  42 IGILPGDGVGPIIMKQALRVLNHL-LQKEIaekkieIRIIDGLTIENRSAKmqTVPDDVLEAIKKCNVILKGPTVTPKAt 120
Cdd:PRK14025   4 ICVIEGDGIGKEVVPAALHVLEATgLPFEF------VYAEAGDEVFEKTGK--ALPEETIEAAKEADAVLFGAAGETAA- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 121 dpwpnlpSANATLRRELDLFANLRPVK----IP--EKNIDWAFFRENIEGAYilgsKGIQ--VNEDLAIDFVVETKQGSD 192
Cdd:PRK14025  75 -------DVIVKLRRILDTYANVRPVKsykgVKclYPDIDYVIVRENTEGLY----KGIEaeIADGVTVATRVITRKASE 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 193 RIARAAFEYAKN----NGKKNITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNPEFnkgLEVFV 267
Cdd:PRK14025 144 RIFRFAFEMAKRrkkmGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIiTRPQT---FDVVV 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 268 LPNLYGDIITDIAAEIQGGLGTAGSANIGKRYAVFEAIHGTAPDLINNGrgdYANPCSLLRAVAMLLSHIGYNDKSFQLD 347
Cdd:PRK14025 221 TSNLFGDILSDGAAGLVGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKG---IANPTATILTAVLMLRHLGENEEADKVE 297


                 ....
gi 503545240 348 KALE 351
Cdd:PRK14025 298 KALE 301
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 44-382 1.95e-60

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 199.72  E-value: 1.95e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  44 ILPGDGVGPIIMKQALRVLNHL-LQKEIAEKKIeiriidGLTIENRSAKMQTVpdDVLEAIKKCNVILKGPTVTPKATdp 122
Cdd:PLN00118  46 LFPGDGIGPEIAESVKQVFTAAgVPIEWEEHYV------GTTVDPRTGSFLTW--ESLESVRRNKVGLKGPMATPIGK-- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 123 wpNLPSANATLRRELDLFANLRPV------KIPEKNIDWAFFRENIEGAYilgsKGIqvnEDLAIDFVVE-----TKQGS 191
Cdd:PLN00118 116 --GHRSLNLTLRKELGLYANVRPCyslpgyKTRYDDVDLVTIRENTEGEY----SGL---EHQVVRGVVEslkiiTRQAS 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 192 DRIARAAFEYAKNNGKKNITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNPEFnkgLEVFVLPN 270
Cdd:PLN00118 187 LRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLvKNPAL---FDVLVMPN 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 271 LYGDIITDIAAEIQGGLGTAGSANIGKR-YAVFEAIHGTAPDLINNgrgDYANPCSLLRAVAMLLSHIGYNDKSFQLDKA 349
Cdd:PLN00118 264 LYGDIISDLCAGLIGGLGLTPSCNIGENgLALAEAVHGSAPDIAGK---NLANPTALLLSAVMMLRHLKLNEQAEQIHNA 340

                        330       340       350
                 ....*....|....*....|....*....|...
gi 503545240 350 LeICTITERKVVVTTKKTDASAAEFTDYLLETL 382
Cdd:PLN00118 341 I-LNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 42-384 1.52e-59

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 196.86  E-value: 1.52e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  42 IGILPGDGVGPIIMKQALRVLNHLLQKEIAEKKIEIRIIDGLTIENRSAKMqtvPDDVLEAIKKCNVILKGPTVTPKatd 121
Cdd:PRK00772   5 IAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPL---PEETLEACRAADAVLLGAVGGPK--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 122 pWPNLPSANA------TLRRELDLFANLRPVKI-----------PE--KNIDWAFFRENIEGAYILGSKGIQVN--EDLA 180
Cdd:PRK00772  79 -WDNLPPDVRpergllALRKELGLFANLRPAKLypgladasplkPEivAGLDILIVRELTGGIYFGEPRGREGLggEERA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 181 IDFVVETKQGSDRIARAAFEYAKNNGKKnITVVTKANIVKlTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNPef 259
Cdd:PRK00772 158 FDTMVYTREEIERIARVAFELARKRRKK-VTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLvRNP-- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 260 nKGLEVFVLPNLYGDIITDIAAEIQGGLGTAGSANIG-KRYAVFEAIHGTAPDLInnGRGdYANPCSLLRAVAMLLSHig 338
Cdd:PRK00772 234 -KQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGeSGPGLYEPIHGSAPDIA--GKG-IANPIATILSAAMMLRY-- 307

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503545240 339 yndkSFQL-----------DKALE--ICT--ITERKVVVTTKktdasaaEFTDYLLETLKR 384
Cdd:PRK00772 308 ----SLGLeeaadaieaavEKVLAqgYRTadIAEGGGKVSTS-------EMGDAILAALAE 357
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 38-384 3.51e-57

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 192.25  E-value: 3.51e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  38 DKVIIGILPGDGVGPIIMKQALRVLNHLLQKE-IAEKKIEIRIIDgLTIENRSAKMQTVPDDVLEAIKKCNVILKGPTVT 116
Cdd:COG0538   17 DNPIIPFIEGDGIGPEITRAIWKVIDAAVEKAyGGKRDIEWKEVD-AGEKARDETGDWLPDETAEAIKEYGVGIKGPLTT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 117 PKAtDPWPnlpSANATLRRELDLFANLRPVKI----------PEKnIDWAFFREN-------IEgaYILGSKG------- 172
Cdd:COG0538   96 PVG-GGWR---SLNVTIRQILDLYVCRRPVRYfkgvpspvkhPEK-VDIVIFRENtediyagIE--WKAGSPEalkliff 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 173 ---------IQVNEDLAIDFVVETKQGSDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGNFikavRKVGQ-----EYP 238
Cdd:COG0538  169 ledemgvtvIRFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAF----KDWGYevaeeEFG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 239 DIDIQERYVD-----ATAAK---------------LNNPEfnkGLEVFVLPNLYGDIITDIAAEIQGGLGTAGSANIG-K 297
Cdd:COG0538  245 DKFITEGPWEkykgpKPAGKivykdriaddmlqqiLLRPG---EYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGdD 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 298 RYAVFEAIHGTAPDLinnGRGDYANPCSLLRAVAMLLSHIGYNDKSFQLDKALEiCTITERKVvvtTK--------KTDA 369
Cdd:COG0538  322 GGAEFEATHGTAPKY---AGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVE-KTIESGKV---TYdlarlmegATEL 394

                        410
                 ....*....|....*
gi 503545240 370 SAAEFTDYLLETLKR 384
Cdd:COG0538  395 STSEFGDAIIENLDK 409
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 42-372 1.36e-54

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 183.59  E-value: 1.36e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  42 IGILPGDGVGPIIMKQALRVLNHLLQKEIAEKKIEIRiidgLTIENRSAKMQTVPDDVLEAIKKCNVILKG----PTVTP 117
Cdd:PRK03437   7 LAVIPGDGIGPEVVAEALKVLDAVAAGGPGVETTEYD----LGARRYLRTGETLPDSVLAELRQHDAILLGaigdPSVPS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 118 KATDPWPNLPsanatLRRELDLFANLRPVKI------PEKN---IDWAFFRENIEGAYIlGSKG-IQVN--EDLAIDFVV 185
Cdd:PRK03437  83 GVLERGLLLK-----LRFALDHYVNLRPSKLypgvtsPLAGpgdIDFVVVREGTEGPYT-GNGGaLRVGtpHEVATEVSV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 186 ETKQGSDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNPEFnkgLE 264
Cdd:PRK03437 157 NTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMvTDPSR---FD 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 265 VFVLPNLYGDIITDIAAEIQGGLGTAGSANI---GKRYAVFEAIHGTAPDLINNGRgdyANPCSLLRAVAMLLSHIGYND 341
Cdd:PRK03437 234 VIVTDNLFGDIITDLAAAVTGGIGLAASGNInptGTNPSMFEPVHGSAPDIAGQGI---ADPTAAILSVALLLDHLGEED 310

                        330       340       350
                 ....*....|....*....|....*....|..
gi 503545240 342 KSFQLDKALEICTITERKVVVTTKKT-DASAA 372
Cdd:PRK03437 311 AAARIEAAVEADLAERGKMGRSTAEVgDRIAA 342
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 41-382 8.02e-54

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 181.99  E-value: 8.02e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  41 IIGILPGDGVGPIIMKQALRVLNhLLQKEIAEKKIEIRiidgltienrsAKMQTVPDDVLEAIKKCNVILKGPTVTPKAT 120
Cdd:PLN00123  32 AVTLIPGDGIGPLVTGAVEQVME-AMHAPVYFERYEVH-----------GDMKKVPEEVLESIRRNKVCLKGGLATPVGG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 121 dpwpNLPSANATLRRELDLFANL-RPVKIP-----EKNIDWAFFRENIEGAYilgsKGIqvnEDLAIDFVVE-----TKQ 189
Cdd:PLN00123 100 ----GVSSLNVQLRKELDLFASLvNCFNLPglptrHENVDIVVIRENTEGEY----SGL---EHEVVPGVVEslkviTKF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 190 GSDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAKL-NNPEfnkGLEVFVL 268
Cdd:PLN00123 169 CSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLvSKPE---QFDVMVT 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 269 PNLYGDIITDIAAEIQGGLGTAGSANIGKRYAVFEaiHGTAPDLINNGR---GDYANPCSLLRAVAMLLSHIGYNDKSFQ 345
Cdd:PLN00123 246 PNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFE--QGASAGNVGNEKlveQKKANPVALLLSSAMMLRHLQFPSFADR 323

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 503545240 346 LDKALEIcTITERKVVVTTKKTDASAAEFTDYLLETL 382
Cdd:PLN00123 324 LETAVKR-VIAEGKYRTKDLGGSSTTQEVVDAVIANL 359
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 39-385 2.84e-48

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 167.21  E-value: 2.84e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  39 KVIIGILPGDGVGPIIMKQALRVLnhllqKEIAEkkieirIIDGLTIEN-----------RSAKMqtVPDDVLEAIKKCN 107
Cdd:PRK08194   3 QFKIAVIPGDGVGKEVVPAAVRVL-----KAVAE------VHGGLKFEFtefpwsceyylEHGEM--MPEDGLEQLKQFD 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 108 VILKG----PTVTPKATDPWPNLpsanATLRRELDLFANLRPVKI------PEKN---IDWAFFRENIEGAYI-LGSKGI 173
Cdd:PRK08194  70 AIFLGavgnPKLVPDHISLWGLL----IKIRREFEQVINIRPAKQlrgiksPLANpkdFDLLVVRENSEGEYSeVGGRIH 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 174 QVNEDLAIDFVVETKQGSDRIARAAFEYAKNNgKKNITVVTKANIVKLTDGNFIKAVRKVGQEYPDIDIQERYVDATAAK 253
Cdd:PRK08194 146 RGEDEIAIQNAVFTRKGTERAMRYAFELAAKR-RKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 254 L-NNPEfnkGLEVFVLPNLYGDIITDIAAEIQGGLGTAGSANI---GKRYAVFEAIHGTAPDLInnGRGdYANPCSLLRA 329
Cdd:PRK08194 225 FvTRPE---EFDVIVASNLFGDILTDIGAAIMGSIGIAPAANInvnGKYPSMFEPVHGSAPDIA--GKG-IANPIGQIWT 298

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 503545240 330 VAMLLSHIGYNDKSFQLDKALEicTITERKVVVTTKKTDASAAEFTDYLLETLKRI 385
Cdd:PRK08194 299 AKLMLDHFGEEELGSHLLDVIE--DVTEDGIKTPDIGGRATTDEVTDEIISRLKKL 352
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 38-382 7.17e-46

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 162.15  E-value: 7.17e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  38 DKVIIGILPGDGVGPIIMKQALRVLNHLLQKEIA-EKKIE-IRIIDGLTIENRSAKMQTVPDDVLEAIKKCNVILKGPTV 115
Cdd:PRK07006  18 NNPIIPFIEGDGIGPDITPAMLKVVDAAVEKAYKgERKISwMEIYAGEKATKVYGEDVWLPEETLDLIREYRVAIKGPLT 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 116 TPKATdpwpNLPSANATLRRELDLFANLRP----------VKIPEKnIDWAFFRENIEGAYI------------------ 167
Cdd:PRK07006  98 TPVGG----GIRSLNVALRQELDLYVCLRPvryfkgvpspVKRPED-TDMVIFRENSEDIYAgiewkagsaeakkvikfl 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 168 ---LGSKGIQVNEDLAIDFVVETKQGSDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGNFIK-----AVRKVGQEYPD 239
Cdd:PRK07006 173 qeeMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDwgyqlAEEEFGDELID 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 240 IDIQERYVDATAAK----------------LNNP-EFnkglEVFVLPNLYGDIITDIAAEIQGGLGTAGSANIGKRYAVF 302
Cdd:PRK07006 253 GGPWDKIKNPETGKeiivkdsiadaflqqiLLRPaEY----DVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIF 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 303 EAIHGTAPDLINNgrgDYANPCSLLRAVAMLLSHIGYNDKSFQLDKALEiCTITERKVV-----VTTKKTDASAAEFTDY 377
Cdd:PRK07006 329 EATHGTAPKYAGL---DKVNPGSVILSAEMMLRHMGWTEAADLIIKSME-KTIASKTVTydfarLMEGATEVKCSEFGDA 404


                 ....*
gi 503545240 378 LLETL 382
Cdd:PRK07006 405 LIKNM 409
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
38-385 6.45e-44

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 157.30  E-value: 6.45e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  38 DKVIIGILPGDGVGPIIMKQALRVLNHLLQKEIAEKKiEIRIIDGLTIENRSAKM-QTVPDDVLEAIKKCNVILKGPTVT 116
Cdd:PRK06451  22 KKPIILYVEGDGIGPEITHAAMKVINKAVEKAYGSDR-EIKWVEVLAGDKAEKLTgNRFPKESEELIEKYRVLLKGPLET 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 117 PKATDpWPnlpSANATLRRELDLFANLRPVKI----------PEKnIDWAFFRENIEGAY------------------IL 168
Cdd:PRK06451 101 PIGKG-WK---SINVAIRLMLDLYANIRPVKYipgiesplknPEK-IDLIIFRENTDDLYrgieypydseeakkirdfLR 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 169 GSKGIQVNEDLAIDFVVETKQGSDRIARAAFEYAKNNGKKNITVVTKANIVKLTDGNFIKAVRKVG-QEYPD-------- 239
Cdd:PRK06451 176 KELGVEVEDDTGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVAlKEFRDyvvteeev 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 240 ------------IDIQERYVDATAAKL-NNPEfnkGLEVFVLPNLYGDIITDIAAEIQGGLGTAGSANIGKRYAVFEAIH 306
Cdd:PRK06451 256 tknyngvppsgkVIINDRIADNMFQQIiIRPD---EYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFEAIH 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 307 GTAPDLINNgrgDYANPCSLLRAVAMLLSHIGYNDKSFQLDKALEIcTITERKVVVTTKK----TDASAAEFTDYLLETL 382
Cdd:PRK06451 333 GTAPKYAGK---NVANPTGIIKGGELMLRFMGWDKAADLIDKAIME-SIKQKKVTQDLARfmgvRALSTTEYTDELISII 408


                 ...
gi 503545240 383 KRI 385
Cdd:PRK06451 409 DML 411
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 42-336 1.89e-28

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 115.17  E-value: 1.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  42 IGILPGDGVGPIIMKQALRVLNHLLQKEIAEKKIEIRIIDGLTIENRSAKMqtvPDDVLEAIKKCNVILKGPTVTPKATD 121
Cdd:PLN02329  49 IALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPL---PEETFTAAKQSDAILLGAIGGYKWDK 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 122 PWPNLPSANA--TLRRELDLFANLRPVKI-PE------------KNIDWAFFRENIEGAYILGSKGIQVN---EDLAIDF 183
Cdd:PLN02329 126 NEKHLRPEMAlfYLRRDLKVFANLRPATVlPQlvdastlkkevaEGVDMMIVRELTGGIYFGEPRGITINengEEVGVST 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 184 VVETKQGSDRIARAAFEYAKNNGKKnITVVTKANIVkltDGNFI--KAVRKVGQEYPDIDIQERYVDATAAKLnnPEFNK 261
Cdd:PLN02329 206 EIYAAHEIDRIARVAFETARKRRGK-LCSVDKANVL---DASILwrKRVTALASEYPDVELSHMYVDNAAMQL--IRDPK 279

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503545240 262 GLEVFVLPNLYGDIITDIAAEIQGGLGTAGSANIGKR-YAVFEAIHGTAPDLINNgrgDYANPCSLLRAVAMLLSH 336
Cdd:PLN02329 280 QFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEPIHGSAPDIAGQ---DKANPLATILSAAMLLKY 352
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
38-360 1.28e-25

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 107.88  E-value: 1.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240  38 DKVIIGILPGDGVGPIIMKQALRVLNHLLQKEIA-EKKIE-IRIIDGLTIENRSAKMQTVPDDVLEAIKKCNVILKGPTV 115
Cdd:PRK07362  27 DNPIIPFIRGDGTGVDIWPATQKVLDAAVAKAYGgERKINwFKVYAGDEACDLYGTYQYLPEDTLEAIREYGVAIKGPLT 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 116 TPKATdpwpNLPSANATLRRELDLFANLRPVKI------PEKN---IDWAFFRENIEGAYI------------------- 167
Cdd:PRK07362 107 TPIGG----GIRSLNVALRQIFDLYSCVRPCRYyagtpsPHKNpekLDVIVYRENTEDIYMgieweagdeigdklikhln 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 168 ---------LGSKGIQVNEDLAIDFVveTKQGSDRIARAAFEYAK--NNGKKNITVVTKANIVKLTDGNFikavRKVGQE 236
Cdd:PRK07362 183 eevipaspeLGKRQIPLGSGIGIKPV--SKTGSQRHIRRAIEHALrlPGDKRHVTLVHKGNIMKYTEGAF----RDWGYE 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 237 Y------------------------PDIDIQE--RYVDA-----TAAK-----------LNNPEFNKG------------ 262
Cdd:PRK07362 257 LattefrdecvtereswilsnkeknPNISIEDnaRMIEPgydslTPEKkaaicaevkevLDSIWSSHGngkwkekvlvdd 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503545240 263 ----------------LEVFVLPNLYGDIITDIAAEIQGGLGTAGSANIGKRYAVFEAIHGTAPdliNNGRGDYANPCSL 326
Cdd:PRK07362 337 riadsifqqiqtrpqeYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAP---KHAGLDRINPGSV 413

                        410       420       430
                 ....*....|....*....|....*....|....
gi 503545240 327 LRAVAMLLSHIGYNDKSFQLDKALEIcTITERKV 360
Cdd:PRK07362 414 ILSGVMMLEYLGWQEAADLITKGLSA-AIANKQV 446
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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