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Conserved domains on  [gi|503500032|ref|WP_013734693|]
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class I SAM-dependent methyltransferase [Micromonospora maris]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10552639)

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_14 pfam08484
C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase ...
 242-399 3.87e-81

C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as pfam08241 or pfam08242. But this domain is not a methyltransferase.


:

Pssm-ID: 430022  Cd Length: 160  Bit Score: 245.83  E-value: 3.87e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  242 PLHGGEIRYTLARP--GRRPIRPAVADMLAREQSSGLIERDTLARFARAVAQIREDLVDLLRGLRAEGRTVVGYGAPGKT 319
Cdd:pfam08484   1 PTHGGSLRVYAARKegGARPVSPAVAALLAEERAAGLDTLATYAGFAERVERVKDELLALLIDLKAEGKRVAGYGAAAKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  320 ATVTTYCGIGPDLLPFTCDSTPAKQGLLVPGSHIPVLPPAEFEAARPDYALLFAWNHAEEIMAKEKAFRDRGGRWIRYVP 399
Cdd:pfam08484  81 NTLLNYCGIGPDLLDYVVDRNPAKQGRYTPGTHIPIVPPEKLREDRPDYVLILPWNLADEIMAQLAEYREWGGKFIVPVP 160
Methyltransf_13 pfam08421
Putative zinc binding domain; This domain is found at the N-terminus of bacterial ...
 4-63 4.91e-18

Putative zinc binding domain; This domain is found at the N-terminus of bacterial methyltransferases and contains four conserved cysteines suggesting a potential zinc binding domain.


:

Pssm-ID: 429987  Cd Length: 62  Bit Score: 77.62  E-value: 4.91e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503500032    4 CRICGGA-VGELLDLGRQPSANRFLSPEEAPQ-EYLFRLAIGACDTCTMVQLMEDVPQEVRY 63
Cdd:pfam08421   1 CRLCGSPlLTPFLDLGRQPLANAFLTPEQLDQpEPFYPLRLVVCEDCGLVQLEEVVPPEELF 62
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
85-235 1.26e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


:

Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 68.87  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  85 ARRLLETELTGPDPFIVEIGCNDGVLLEHIAQAGVRHLGVEPAASVAALAEAKGVtvrnsfFDDVTAAEIR----TGRGA 160
Cdd:COG4976   35 AEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGV------YDRLLVADLAdlaePDGRF 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503500032 161 DVIYGANTICHIAYQDALFRGVDTLLAPDGVFVMVEPYLGtivhgmafdqiyDEHVYYFTAHSVRAMARTFGFEL 235
Cdd:COG4976  109 DLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSVEDAD------------GSGRYAHSLDYVRDLLAAAGFEV 171
 
Name Accession Description Interval E-value
Methyltransf_14 pfam08484
C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase ...
 242-399 3.87e-81

C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as pfam08241 or pfam08242. But this domain is not a methyltransferase.


Pssm-ID: 430022  Cd Length: 160  Bit Score: 245.83  E-value: 3.87e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  242 PLHGGEIRYTLARP--GRRPIRPAVADMLAREQSSGLIERDTLARFARAVAQIREDLVDLLRGLRAEGRTVVGYGAPGKT 319
Cdd:pfam08484   1 PTHGGSLRVYAARKegGARPVSPAVAALLAEERAAGLDTLATYAGFAERVERVKDELLALLIDLKAEGKRVAGYGAAAKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  320 ATVTTYCGIGPDLLPFTCDSTPAKQGLLVPGSHIPVLPPAEFEAARPDYALLFAWNHAEEIMAKEKAFRDRGGRWIRYVP 399
Cdd:pfam08484  81 NTLLNYCGIGPDLLDYVVDRNPAKQGRYTPGTHIPIVPPEKLREDRPDYVLILPWNLADEIMAQLAEYREWGGKFIVPVP 160
Methyltransf_13 pfam08421
Putative zinc binding domain; This domain is found at the N-terminus of bacterial ...
 4-63 4.91e-18

Putative zinc binding domain; This domain is found at the N-terminus of bacterial methyltransferases and contains four conserved cysteines suggesting a potential zinc binding domain.


Pssm-ID: 429987  Cd Length: 62  Bit Score: 77.62  E-value: 4.91e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503500032    4 CRICGGA-VGELLDLGRQPSANRFLSPEEAPQ-EYLFRLAIGACDTCTMVQLMEDVPQEVRY 63
Cdd:pfam08421   1 CRLCGSPlLTPFLDLGRQPLANAFLTPEQLDQpEPFYPLRLVVCEDCGLVQLEEVVPPEELF 62
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
85-235 1.26e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 68.87  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  85 ARRLLETELTGPDPFIVEIGCNDGVLLEHIAQAGVRHLGVEPAASVAALAEAKGVtvrnsfFDDVTAAEIR----TGRGA 160
Cdd:COG4976   35 AEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGV------YDRLLVADLAdlaePDGRF 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503500032 161 DVIYGANTICHIAYQDALFRGVDTLLAPDGVFVMVEPYLGtivhgmafdqiyDEHVYYFTAHSVRAMARTFGFEL 235
Cdd:COG4976  109 DLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSVEDAD------------GSGRYAHSLDYVRDLLAAAGFEV 171
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 87-236 1.32e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 68.22  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032   87 RLLETELTGPDpfIVEIGCNDGVLLEHIAQAGVRHLGVEPAASVAALAEakgVTVRNSFFDDVTAAEirTGRGADVIYGA 166
Cdd:pfam13489  15 RLLPKLPSPGR--VLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERAL---LNVRFDQFDEQEAAV--PAGKFDVIVAR 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503500032  167 NTICHIAYQDALFRGVDTLLAPDGVFVMVEPyLGTIVHGMAFDQI-----YDEHVYYFTAHSVRAMARTFGFELV 236
Cdd:pfam13489  88 EVLEHVPDPPALLRQIAALLKPGGLLLLSTP-LASDEADRLLLEWpylrpRNGHISLFSARSLKRLLEEAGFEVV 161
ABC_Metallic_Cations cd03235
ATP-binding cassette domain of the metal-type transporters; This family includes transporters ...
 236-311 9.29e-03

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.


Pssm-ID: 213202 [Multi-domain]  Cd Length: 213  Bit Score: 37.13  E-value: 9.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032 236 VDVEDVPLHGGEIRYTLARPGRRPIRPAVADMLAREQSSGLIER--DTL-------ARFARAVAQ--------------- 291
Cdd:cd03235   85 ISVRDVVLMGLYGHKGLFRRLSKADKAKVDEALERVGLSELADRqiGELsggqqqrVLLARALVQdpdlllldepfagvd 164

                         90       100
                 ....*....|....*....|..
gi 503500032 292 --IREDLVDLLRGLRAEGRTVV 311
Cdd:cd03235  165 pkTQEDIYELLRELRREGMTIL 186
 
Name Accession Description Interval E-value
Methyltransf_14 pfam08484
C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase ...
 242-399 3.87e-81

C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as pfam08241 or pfam08242. But this domain is not a methyltransferase.


Pssm-ID: 430022  Cd Length: 160  Bit Score: 245.83  E-value: 3.87e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  242 PLHGGEIRYTLARP--GRRPIRPAVADMLAREQSSGLIERDTLARFARAVAQIREDLVDLLRGLRAEGRTVVGYGAPGKT 319
Cdd:pfam08484   1 PTHGGSLRVYAARKegGARPVSPAVAALLAEERAAGLDTLATYAGFAERVERVKDELLALLIDLKAEGKRVAGYGAAAKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  320 ATVTTYCGIGPDLLPFTCDSTPAKQGLLVPGSHIPVLPPAEFEAARPDYALLFAWNHAEEIMAKEKAFRDRGGRWIRYVP 399
Cdd:pfam08484  81 NTLLNYCGIGPDLLDYVVDRNPAKQGRYTPGTHIPIVPPEKLREDRPDYVLILPWNLADEIMAQLAEYREWGGKFIVPVP 160
Methyltransf_13 pfam08421
Putative zinc binding domain; This domain is found at the N-terminus of bacterial ...
 4-63 4.91e-18

Putative zinc binding domain; This domain is found at the N-terminus of bacterial methyltransferases and contains four conserved cysteines suggesting a potential zinc binding domain.


Pssm-ID: 429987  Cd Length: 62  Bit Score: 77.62  E-value: 4.91e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503500032    4 CRICGGA-VGELLDLGRQPSANRFLSPEEAPQ-EYLFRLAIGACDTCTMVQLMEDVPQEVRY 63
Cdd:pfam08421   1 CRLCGSPlLTPFLDLGRQPLANAFLTPEQLDQpEPFYPLRLVVCEDCGLVQLEEVVPPEELF 62
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
85-235 1.26e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 68.87  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  85 ARRLLETELTGPDPFIVEIGCNDGVLLEHIAQAGVRHLGVEPAASVAALAEAKGVtvrnsfFDDVTAAEIR----TGRGA 160
Cdd:COG4976   35 AEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGV------YDRLLVADLAdlaePDGRF 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503500032 161 DVIYGANTICHIAYQDALFRGVDTLLAPDGVFVMVEPYLGtivhgmafdqiyDEHVYYFTAHSVRAMARTFGFEL 235
Cdd:COG4976  109 DLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSVEDAD------------GSGRYAHSLDYVRDLLAAAGFEV 171
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 87-236 1.32e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 68.22  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032   87 RLLETELTGPDpfIVEIGCNDGVLLEHIAQAGVRHLGVEPAASVAALAEakgVTVRNSFFDDVTAAEirTGRGADVIYGA 166
Cdd:pfam13489  15 RLLPKLPSPGR--VLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERAL---LNVRFDQFDEQEAAV--PAGKFDVIVAR 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503500032  167 NTICHIAYQDALFRGVDTLLAPDGVFVMVEPyLGTIVHGMAFDQI-----YDEHVYYFTAHSVRAMARTFGFELV 236
Cdd:pfam13489  88 EVLEHVPDPPALLRQIAALLKPGGLLLLSTP-LASDEADRLLLEWpylrpRNGHISLFSARSLKRLLEEAGFEVV 161
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 100-197 7.49e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 59.26  E-value: 7.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032 100 IVEIGCNDGVLLEHIAQAGVRHLGVEPAASVAALAEAKGVTVRNSFF-DDVTAAEIRTGRgADVIYGANTICHIAYQDAL 178
Cdd:COG2227   28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNVDFVqGDLEDLPLEDGS-FDLVICSEVLEHLPDPAAL 106

                         90
                 ....*....|....*....
gi 503500032 179 FRGVDTLLAPDGVFVMVEP 197
Cdd:COG2227  107 LRELARLLKPGGLLLLSTP 125
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 101-192 1.40e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 46.21  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  101 VEIGCNDGVLLEHIAQA--GVRHLGVEPAASVAALAEAKGVTVRNSFFDDVTAAEI----RTGRGADVIYGANTICHIAY 174
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLdlgeLDPGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*...
gi 503500032  175 QDALFRGVDTLLAPDGVF 192
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
100-196 8.11e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.04  E-value: 8.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032 100 IVEIGCNDGVLLEHIAQA--GVRHLGVE--PAASVAALAEAKGVTVRNSffddvTAAEIRTGRGADVIYGANTICHIAYQ 175
Cdd:COG4106    5 VLDLGCGTGRLTALLAERfpGARVTGVDlsPEMLARARARLPNVRFVVA-----DLRDLDPPEPFDLVVSNAALHWLPDH 79

                         90       100
                 ....*....|....*....|.
gi 503500032 176 DALFRGVDTLLAPDGVFVMVE 196
Cdd:COG4106   80 AALLARLAAALAPGGVLAVQV 100
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 84-196 5.93e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 39.98  E-value: 5.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  84 EARRLLETELTGPDPFIVEIGCNDGVLLEHIAQAGVRHLGVEP------AASVAALAEAKGVTVRNSffdDVTAAEIRTG 157
Cdd:COG2226   10 GREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDIspemleLARERAAEAGLNVEFVVG---DAEDLPFPDG 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 503500032 158 RgADVIYGANTICHIAYQDALFRGVDTLLAPDGVFVMVE 196
Cdd:COG2226   87 S-FDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVD 124
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 79-195 1.22e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 39.90  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  79 KFFAGEARRLLETELTG----PDPF-IVEIGCNDGVLLEHIAQAGVRH-LGVEPAAS-------VAALAEAKGVTVRNsf 145
Cdd:COG0500    4 SYYSDELLPGLAALLALlerlPKGGrVLDLGCGTGRNLLALAARFGGRvIGIDLSPEaialaraRAAKAGLGNVEFLV-- 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 503500032 146 fDDVTAAEIRTGRGADVIYGANTICHI--AYQDALFRGVDTLLAPDGVFVMV 195
Cdd:COG0500   82 -ADLAELDPLPAESFDLVVAFGVLHHLppEEREALLRELARALKPGGVLLLS 132
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 101-194 1.93e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 37.26  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032  101 VEIGCNDGVLLEHIAQAGVRHLGVEPAASVAALAEAKGVTVRNSFFD-DVTAAEIRTGRgADVIYGANTICHIAYQDALF 179
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVVgDAEDLPFPDNS-FDLVLSSEVLHHVEDPERAL 79

                          90
                  ....*....|....*
gi 503500032  180 RGVDTLLAPDGVFVM 194
Cdd:pfam08241  80 REIARVLKPGGILII 94
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 100-197 3.94e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 37.60  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032 100 IVEIGCNDGVLLEHIAQA-GVRHLGV----EPAASVAALAEAKGVTvrnsffDDVT-----AAEIRTGRGADVIYGANTI 169
Cdd:COG2230   55 VLDIGCGWGGLALYLARRyGVRVTGVtlspEQLEYARERAAEAGLA------DRVEvrladYRDLPADGQFDAIVSIGMF 128

                         90       100       110
                 ....*....|....*....|....*....|
gi 503500032 170 CHI--AYQDALFRGVDTLLAPDGVFVMVEP 197
Cdd:COG2230  129 EHVgpENYPAYFAKVARLLKPGGRLLLHTP 158
ABC_Metallic_Cations cd03235
ATP-binding cassette domain of the metal-type transporters; This family includes transporters ...
 236-311 9.29e-03

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.


Pssm-ID: 213202 [Multi-domain]  Cd Length: 213  Bit Score: 37.13  E-value: 9.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503500032 236 VDVEDVPLHGGEIRYTLARPGRRPIRPAVADMLAREQSSGLIER--DTL-------ARFARAVAQ--------------- 291
Cdd:cd03235   85 ISVRDVVLMGLYGHKGLFRRLSKADKAKVDEALERVGLSELADRqiGELsggqqqrVLLARALVQdpdlllldepfagvd 164

                         90       100
                 ....*....|....*....|..
gi 503500032 292 --IREDLVDLLRGLRAEGRTVV 311
Cdd:cd03235  165 pkTQEDIYELLRELRREGMTIL 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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